KR20220142474A - 유전자 변형 동물을 생산하기 위한 조성물 및 방법 - Google Patents

유전자 변형 동물을 생산하기 위한 조성물 및 방법 Download PDF

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Publication number
KR20220142474A
KR20220142474A KR1020227031535A KR20227031535A KR20220142474A KR 20220142474 A KR20220142474 A KR 20220142474A KR 1020227031535 A KR1020227031535 A KR 1020227031535A KR 20227031535 A KR20227031535 A KR 20227031535A KR 20220142474 A KR20220142474 A KR 20220142474A
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South Korea
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gene
sequence
human
cell
cells
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KR1020227031535A
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Korean (ko)
Inventor
프랭크 코엔티젠
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오즈진 홀딩스 프로프라이어터리 리미티드
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Priority claimed from AU2013904307A external-priority patent/AU2013904307A0/en
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Priority to KR1020247010776A priority Critical patent/KR20240049835A/ko
Publication of KR20220142474A publication Critical patent/KR20220142474A/ko
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8775—Murine embryos
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
KR1020227031535A 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법 Ceased KR20220142474A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247010776A KR20240049835A (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
AU2013904307 2013-11-07
AU2013904307A AU2013904307A0 (en) 2013-11-07 Compositions and methods for producing genetically modified animals
AU2014902162A AU2014902162A0 (en) 2014-06-06 Compostion and methods for producing genetically modified animals
AU2014902162 2014-06-06
PCT/AU2014/050339 WO2015066768A1 (en) 2013-11-07 2014-11-07 Compositions and methods for producing genetically modified animals
KR1020167015094A KR102444117B1 (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020167015094A Division KR102444117B1 (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020247010776A Division KR20240049835A (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법

Publications (1)

Publication Number Publication Date
KR20220142474A true KR20220142474A (ko) 2022-10-21

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Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020227031535A Ceased KR20220142474A (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법
KR1020167015094A Active KR102444117B1 (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법
KR1020247010776A Ceased KR20240049835A (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법

Family Applications After (2)

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KR1020167015094A Active KR102444117B1 (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법
KR1020247010776A Ceased KR20240049835A (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법

Country Status (15)

Country Link
US (2) US20160360736A1 (enExample)
EP (2) EP3066204B1 (enExample)
JP (2) JP6845013B2 (enExample)
KR (3) KR20220142474A (enExample)
CN (1) CN105899667A (enExample)
AU (2) AU2014346342C1 (enExample)
CA (1) CA2928744C (enExample)
DK (1) DK3066204T3 (enExample)
ES (1) ES2886146T3 (enExample)
HU (1) HUE055766T2 (enExample)
IL (2) IL307495B2 (enExample)
NZ (2) NZ719493A (enExample)
PT (1) PT3066204T (enExample)
SG (2) SG11201603352SA (enExample)
WO (1) WO2015066768A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201603352SA (en) 2013-11-07 2016-05-30 Ozgene Holdings Pty Ltd Compositions and methods for producing genetically modified animals
CN111566202A (zh) * 2018-01-12 2020-08-21 加利福利亚大学董事会 稳定的多能牛胚胎干细胞的高效衍生
GB201816633D0 (en) * 2018-10-12 2018-11-28 Univ Edinburgh Genetically modified avians and method for the reconstitution thereof
CN113136439B (zh) * 2021-05-28 2022-04-08 兰州大学 一种检测绵羊lipe基因单核苷酸多态性的方法及其应用
CN114592011B (zh) * 2022-05-10 2022-08-05 广东药康生物科技有限公司 一种ptdss2条件性基因敲除小鼠模型的构建方法

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JP3034320U (ja) * 1996-08-02 1997-02-18 幸夫 冨澤 蛇腹式カード
JP2001008577A (ja) 1999-06-30 2001-01-16 Mitsubishi Chemicals Corp 生殖毒性化学物質のモニタリングに使用されるトランスジェニックマウス
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
BR0111839A (pt) 2000-06-23 2003-09-16 Du Pont Construções recombinantes, método para a redução da expressão de um mrna alvo ou qualquer mrna endógeno substancialmente similar, rna e método para a identificação ou seleção de um gene vegetal essencial
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AU2003211803A1 (en) * 2002-02-27 2003-09-09 Takuro Horii Method of constructing germline chimeric animal
AU2003213813A1 (en) * 2002-03-22 2003-10-13 St. Jude Children's Research Hospital Improved method for generating genetically modified animals
DK2767161T3 (en) 2004-10-19 2018-05-07 Regeneron Pharma Method of generating an animal homozygous for genetic modification
JP4842891B2 (ja) 2006-12-27 2011-12-21 花王株式会社 ペット用シート
ITRM20090235A1 (it) * 2009-05-12 2010-11-13 Uni Degli Studi Perugia Modello murino ottenuto mediante inattivazione del gene glucocorticoid-induced leucine zipper, metodo per la sua preparazione e relativi usi.
JP4949434B2 (ja) 2009-05-19 2012-06-06 株式会社マーク・コーポレーション ラベルシート
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KR20130030355A (ko) * 2011-09-17 2013-03-27 유종현 배변패드
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KR20140106134A (ko) * 2013-02-26 2014-09-03 윤수경 배변패드 제조장치 및 이를 이용한 배변패드 제조방법
SG11201603352SA (en) 2013-11-07 2016-05-30 Ozgene Holdings Pty Ltd Compositions and methods for producing genetically modified animals
KR20180005002A (ko) * 2016-07-05 2018-01-15 김윤수 애완견 배변패드
KR102311995B1 (ko) * 2018-04-08 2021-10-13 김종수 애완동물 배설물 자동처리장치
CN209403260U (zh) 2018-11-14 2019-09-20 绍兴兴科元管业有限公司 一种宠物尿垫组件

Also Published As

Publication number Publication date
DK3066204T3 (da) 2021-08-30
KR20240049835A (ko) 2024-04-17
AU2014346342B2 (en) 2020-02-20
IL245306A0 (en) 2016-06-30
ES2886146T3 (es) 2021-12-16
HUE055766T2 (hu) 2021-12-28
CA2928744A1 (en) 2015-05-14
PT3066204T (pt) 2021-09-06
CN105899667A (zh) 2016-08-24
JP2020202857A (ja) 2020-12-24
KR20160084431A (ko) 2016-07-13
EP4043575A1 (en) 2022-08-17
EP3066204A4 (en) 2017-06-21
US20160360736A1 (en) 2016-12-15
IL307495B1 (en) 2025-07-01
KR102444117B1 (ko) 2022-09-16
AU2014346342A1 (en) 2016-05-19
JP6845013B2 (ja) 2021-03-17
WO2015066768A1 (en) 2015-05-14
US20220201992A1 (en) 2022-06-30
AU2014346342C1 (en) 2020-08-13
EP3066204B1 (en) 2021-06-02
US11937586B2 (en) 2024-03-26
CA2928744C (en) 2022-12-06
NZ719493A (en) 2020-02-28
NZ758970A (en) 2022-10-28
EP3066204A1 (en) 2016-09-14
SG11201603352SA (en) 2016-05-30
JP2016539660A (ja) 2016-12-22
AU2020202321A1 (en) 2020-04-23
IL307495B2 (en) 2025-11-01
AU2020202321B2 (en) 2021-12-16
IL307495A (en) 2023-12-01
SG10202112147UA (en) 2021-12-30

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