KR20220083861A - Ｐｃｖ2 ｏｒｆ2 단백질 변이체 및 이로 이루어진 바이러스 유사 입자 - Google Patents
Ｐｃｖ2 ｏｒｆ2 단백질 변이체 및 이로 이루어진 바이러스 유사 입자 Download PDFInfo
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- KR20220083861A KR20220083861A KR1020227019654A KR20227019654A KR20220083861A KR 20220083861 A KR20220083861 A KR 20220083861A KR 1020227019654 A KR1020227019654 A KR 1020227019654A KR 20227019654 A KR20227019654 A KR 20227019654A KR 20220083861 A KR20220083861 A KR 20220083861A
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| RU2488407C2 (ru) | 2005-12-29 | 2013-07-27 | Берингер Ингельхайм Ветмедика, Инк. | Поливалентные иммуногенные композиции pcv2 и способы получения таких композиций |
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| EP1958644A1 (en) | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Prevention and treatment of sub-clinical pcvd |
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| CN105658660A (zh) | 2013-10-02 | 2016-06-08 | 勃林格殷格翰动物保健公司 | Pcv2 orf2蛋白变体和由其组成的病毒样颗粒 |
| CN107531760A (zh) * | 2015-03-30 | 2018-01-02 | 勃林格殷格翰动物保健公司 | Pcv2 orf2载体平台 |
| HK1252427A1 (zh) | 2015-05-14 | 2019-05-24 | Boehringer Ingelheim Animal Health USA Inc. | 猪环状病毒生产方法和pcv2疫苗 |
| CN104984335A (zh) * | 2015-07-14 | 2015-10-21 | 浙江诺倍威生物技术有限公司 | 猪圆环病毒双亚型orf2共表达载体构建及疫苗制备 |
| WO2017187277A2 (en) * | 2016-03-07 | 2017-11-02 | Virginia Tech Intellectual Properties, Inc. | Chimeric porcine circovirus type 2 (pcv2) vaccines |
| US10431889B2 (en) * | 2016-04-22 | 2019-10-01 | The Charles Stark Draper Laboratory, Inc. | Low-loss compact transmit impedance matching tuning technique |
| CN106399350B (zh) * | 2016-09-07 | 2020-02-21 | 复旦大学 | 一种猪圆环病毒ii型病毒样颗粒疫苗及其制备方法 |
| CN106399138B (zh) * | 2016-09-07 | 2019-11-12 | 复旦大学 | 猪圆环病毒ii型口服病毒样颗粒疫苗及其制备方法和应用 |
| CN109803678B (zh) * | 2016-11-03 | 2023-08-22 | 勃林格殷格翰动物保健有限公司 | 抗猪细小病毒的疫苗 |
| CN106834242B (zh) * | 2017-03-02 | 2021-02-23 | 扬州大学 | 嵌合型猪圆环病毒活疫苗c1-233株及其构建方法 |
| CN106834241B (zh) * | 2017-03-02 | 2021-01-19 | 扬州大学 | 嵌合型猪圆环病毒活疫苗c1-402株及其构建方法 |
| CN107245477B (zh) * | 2017-06-06 | 2020-06-30 | 广东海大畜牧兽医研究院有限公司 | 一种猪圆环病毒2型病毒样颗粒的制备方法及通过该方法获得的病毒样颗粒 |
| PL3697804T3 (pl) * | 2017-10-17 | 2024-01-03 | Intervet International B.V. | Rekombinowana ekspresja białka orf2 pcv2b w komórkach owadzich |
| CN108484725A (zh) * | 2018-03-16 | 2018-09-04 | 广东海大畜牧兽医研究院有限公司 | 一种区分检测pcv2野毒抗体与疫苗抗体的多肽及其在elisa检测试剂盒中的应用 |
| CN110358742B (zh) * | 2019-07-05 | 2020-12-22 | 武汉科前生物股份有限公司 | 猪圆环病毒2b型和2d型的二价亚单位疫苗及其制备方法 |
| CN111415356B (zh) * | 2020-03-17 | 2020-12-29 | 推想医疗科技股份有限公司 | 肺炎征象的分割方法、装置、介质及电子设备 |
| CN112010949B (zh) * | 2020-08-03 | 2021-07-27 | 山东绿都生物科技有限公司 | 一种重组pcv2病毒样颗粒蜂胶疫苗及其制备方法 |
| CN114250259B (zh) * | 2020-09-21 | 2024-07-19 | 成都史纪生物制药有限公司 | 一种猪圆环2型病毒Cap蛋白病毒样颗粒的发酵培养基 |
| TWI867524B (zh) * | 2022-05-09 | 2024-12-21 | 福又達生物科技股份有限公司 | 豬環狀病毒第二型及豬瘟病毒次單位雙價疫苗 |
| AU2024265654A1 (en) | 2023-05-03 | 2025-12-04 | Boehringer Ingelheim Vetmedica Gmbh | Method for inducing an immune response |
| CN121013728A (zh) | 2023-05-03 | 2025-11-25 | 勃林格殷格翰动物保健有限公司 | 一种可用于猪自我施用的免疫原性组合物 |
| CN118063562B (zh) * | 2024-03-11 | 2025-04-01 | 天康生物制药有限公司 | 优化的猪圆环病毒2型Cap蛋白及其病毒样颗粒和应用 |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2909462A (en) | 1955-12-08 | 1959-10-20 | Bristol Myers Co | Acrylic acid polymer laxative compositions |
| EP0283085B1 (en) | 1987-03-17 | 1992-11-11 | Akzo N.V. | Adjuvant mixture |
| US5069901A (en) | 1988-02-03 | 1991-12-03 | Jones Elaine V | Preparation of a recombinant subunit vaccine against pseudorabies infection |
| DE69027112T2 (de) | 1989-01-23 | 1997-01-09 | Auspharm International Ltd 4Th | Impfstoffzusammensetzung |
| US5155037A (en) | 1989-08-04 | 1992-10-13 | The Texas A&M University System | Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems |
| US5202430A (en) | 1990-01-16 | 1993-04-13 | University Of Tennessee | Transmissible gastroenteritis virus genes |
| JP3187419B2 (ja) | 1990-05-29 | 2001-07-11 | アメリカン・サイアナミド・カンパニー | ブタ肺炎ワクチンおよびその製造方法 |
| US5565205A (en) | 1990-08-16 | 1996-10-15 | Solvay Animal Health, Inc. | Inactivated Mycoplasma hypopneumoniae bacterin and method of use thereof |
| GB9023111D0 (en) | 1990-10-24 | 1990-12-05 | Wellcome Found | Expression system |
| WO1992007934A1 (en) | 1990-11-01 | 1992-05-14 | Iowa State University Research Foundation, Inc. | Bacterial attenuation method and vaccine |
| MX9204885A (es) | 1991-08-26 | 1994-05-31 | Boehringer Animal Health Inc | Composicion de vacuna que comprende virus del sindrome de infertilidad y respiratorio de los cerdos. |
| US6042830A (en) | 1992-08-05 | 2000-03-28 | Boehringer Ingelheim Vetmedica, Inc. | Viral agent associated with mystery swine disease |
| US5580557A (en) | 1991-10-09 | 1996-12-03 | Iowa State University Research Foundation, Inc. | Live, avirulent salmonella choleraesuis vaccine used for inducing an immune response in animals |
| US5338543A (en) | 1992-02-27 | 1994-08-16 | Ambico, Inc. | Thimerosal inactivated mycoplasma hyopneumoniae vaccine |
| CN1268393C (zh) | 1994-05-10 | 2006-08-09 | 惠氏公司 | 经改良修饰的brsv或疫苗 |
| US5885823A (en) | 1995-06-05 | 1999-03-23 | Nobl Laboratories, Inc. | Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents |
| WO1998006835A2 (en) | 1996-08-16 | 1998-02-19 | The Texas A & M University System | Modifying insect cell gylcosylation pathways with baculovirus expression vectors |
| DK0835930T3 (da) | 1996-10-09 | 2001-06-18 | Akzo Nobel Nv | Europæiske vaccinestammer af porcint reproduktions- og respirationssyndrom-virus. (PRRSV) |
| US6517843B1 (en) | 1999-08-31 | 2003-02-11 | Merial | Reduction of porcine circovirus-2 viral load with inactivated PCV-2 |
| FR2781159B1 (fr) | 1998-07-06 | 2000-10-06 | Merial Sas | Vaccin circovirus et parvovirus porcin |
| US7192594B2 (en) | 1997-10-03 | 2007-03-20 | Merial Limited | Postweaning multisystemic wasting syndrome and porcine circovirus from pigs |
| UA78180C2 (uk) | 1997-10-03 | 2007-03-15 | Меріаль | Кільцевий вірус свині типу ii, вакцини та діагностичні реагенти |
| US6391314B1 (en) | 1997-10-03 | 2002-05-21 | Merial | Porcine circoviruses vaccines diagnostic reagents |
| US7211379B2 (en) | 1997-10-03 | 2007-05-01 | Merial Sas | Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2 |
| US20060029617A1 (en) | 1997-10-03 | 2006-02-09 | Charreyre Catherine E | Porcine circovirus and Helicobacter combination vaccines and methods of use |
| FR2772047B1 (fr) | 1997-12-05 | 2004-04-09 | Ct Nat D Etudes Veterinaires E | Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection |
| US20040062775A1 (en) | 1997-12-05 | 2004-04-01 | Agence Francaise De Securite Sanitaire Des Aliments | Circovirus sequences associated with piglet weight loss disease (PWD) |
| ES2289796T3 (es) | 1997-12-11 | 2008-02-01 | University Of Saskatchewan | Virus del sindrome del desmedro post-destete procedente de cerdos. |
| EP1064024A4 (en) | 1998-03-13 | 2005-04-06 | Univ Georgia Res Found | VACCINES AGAINST CIRCOVIRUS INFECTIONS |
| EP0953574A1 (en) * | 1998-04-30 | 1999-11-03 | Innogenetics N.V. | Immunodiagnostic reagent for the detection of Maedi-Visna virus and CAEV infection |
| US6294176B1 (en) | 1998-07-10 | 2001-09-25 | Schering-Plough Veterinary Corp. | Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species |
| DE69933647T2 (de) | 1998-11-19 | 2007-08-23 | Azwell Inc. | Rekombinante lysophosphatidsäure - phosphatase. |
| FR2789695B1 (fr) | 1999-02-11 | 2003-03-07 | Merial Sas | Vecteurs et vaccins viraux a base d'adenovirus porcins recombines et replicatifs |
| US6943152B1 (en) | 1999-06-10 | 2005-09-13 | Merial | DNA vaccine-PCV |
| US6497883B1 (en) | 1999-06-10 | 2002-12-24 | Merial | Porcine circovirus recombinant poxvirus vaccine |
| WO2001017556A1 (fr) | 1999-09-07 | 2001-03-15 | Shionogi & Co., Ltd. | Préparations vaccinales administrables par les muqueuses |
| US6656478B1 (en) | 1999-11-12 | 2003-12-02 | Samuel D. Charles | Cross-protective salmonella vaccines |
| ATE385808T1 (de) | 1999-12-21 | 2008-03-15 | Merial Sas | Mindestens ein cryptosporidium parvum-antigen und mindestens ein antigen eines anderen darmkrankheitserregers enthaltende zusammensetzungen und impfstoffe |
| US6808900B2 (en) | 2000-06-15 | 2004-10-26 | Manitoba, University Of | Cryptosporidium parvum antigens, antibodies thereto and diagnostic and therapeutic compositions thereof |
| MXPA02012352A (es) | 2000-06-15 | 2004-09-06 | Purdue Research Foundation | Vacuna para temblores congenitos en cerdos. |
| MY129765A (en) | 2000-12-19 | 2007-04-30 | Wyeth Corp | Improved mycoplasma hyopneumoniae bacterin vaccine |
| US7018638B2 (en) | 2000-12-19 | 2006-03-28 | Wyeth | Mycoplasma hyopneumoniae bacterin vaccine |
| JP2002247979A (ja) | 2001-02-23 | 2002-09-03 | Nippon Biologicals Inc | マレック病ワクチンおよびその製造方法 |
| SK287969B6 (sk) | 2001-03-27 | 2012-08-06 | University Of Saskatchewan | Method to culture circovirus |
| US20030096377A1 (en) | 2001-06-28 | 2003-05-22 | Virginia Tech Intellectual Properties, Inc. | Differential PCR-RFLP assay for detecting and distinguishing between nonpathogenic PCV-1 and pathogenic PCV-2 |
| CN102872456B (zh) | 2001-07-02 | 2016-01-20 | 硕腾服务有限责任公司 | 单剂量猪肺炎支原体疫苗 |
| US7361352B2 (en) | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| US7279166B2 (en) | 2001-12-12 | 2007-10-09 | Virginia Tech Intellectual Properties, Inc. | Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof |
| US7276353B2 (en) | 2001-12-12 | 2007-10-02 | Virginia Tech Intellectual Properties, Inc. | Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof |
| US6841364B2 (en) | 2002-01-22 | 2005-01-11 | Protatek International, Inc. | Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof |
| AU2003217413A1 (en) | 2002-02-14 | 2003-09-04 | Novavax, Inc. | Method for isolation and purification of expressed gene products in vitro |
| AU2003220240A1 (en) | 2002-03-13 | 2003-09-29 | Biophysica, Inc. | Boswellin compositions enhanced with 3-beta-acety1-11-keto-beta-boswellic acid (akba), industrial manufacture and their uses |
| US20030215455A1 (en) | 2002-05-14 | 2003-11-20 | Bailey Reynolds | Vaccine stabilizer and method of use |
| AU2002951692A0 (en) | 2002-09-23 | 2002-10-17 | Vital Biotech (Hong Kong) Limited | Improvements in or relating to vaccines |
| MXPA05008252A (es) | 2003-02-03 | 2006-05-22 | Cerebus Biolog Inc | Metodos para tratar, prevenir y detectar una infeccion con helicobacter. |
| US7563449B2 (en) | 2003-04-21 | 2009-07-21 | Pfizer Inc, | Methods for reducing cattle reproductive diseases |
| CN1458167A (zh) | 2003-06-02 | 2003-11-26 | 中国农业科学院哈尔滨兽医研究所 | 截短表达的猪圆环病毒ⅱ型衣壳蛋白抗原及其应用 |
| US7335361B2 (en) | 2003-06-09 | 2008-02-26 | Animal Technology Institute Taiwan | Fusion antigen used as vaccine |
| UA84024C2 (ru) | 2003-07-24 | 2008-09-10 | Мериал Лимитед | Новые вакцинные композиции, которые содержат эмульсию типа "масло в воде" |
| JP2006528882A (ja) | 2003-07-25 | 2006-12-28 | ベーリンガー インゲルハイム フェトメディカ インコーポレイテッド | 欧州起源のローソニア・イントラセルラリス並びにそのワクチン、診断薬及び使用方法 |
| FR2861731B1 (fr) | 2003-10-30 | 2006-02-24 | Centre Nat Rech Scient | Nouvelle proteine de fixation du phosphate, compositions pharmaceutiques la contenant et ses utilisations |
| WO2005112995A1 (en) | 2004-04-26 | 2005-12-01 | Choongang Vaccine Laboratory Co., Ltd. | Inactivated mixed vaccine for porcine respiratory disease and the method of manufacturing thereof |
| CN1579553A (zh) | 2004-05-18 | 2005-02-16 | 浙江大学 | Ii型猪圆环病毒核酸疫苗的制备方法及其应用 |
| AU2005319716A1 (en) | 2004-06-30 | 2006-06-29 | Id Biomedical Corporation Of Quebec | Vaccine compositions for treating coronavirus infection |
| US7700285B1 (en) | 2005-12-29 | 2010-04-20 | Boehringer Ingelheim Vetmedica, Inc. | PCV2 immunogenic compositions and methods of producing such compositions |
| US7833707B2 (en) | 2004-12-30 | 2010-11-16 | Boehringer Ingelheim Vetmedica, Inc. | Methods of overexpression and recovery of porcine circovirus type 2 ORF2 |
| EP1838343B1 (en) | 2005-01-13 | 2010-03-31 | Boehringer Ingelheim Vetmedica Gmbh | Prrs vaccines |
| US7300785B2 (en) | 2005-02-03 | 2007-11-27 | Universiteit Ghent | Culturing circular ssDNA viruses for the production of vaccines |
| US8834891B2 (en) | 2005-03-14 | 2014-09-16 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions comprising Lawsonia intracellularis |
| PT1869471T (pt) | 2005-04-13 | 2016-08-16 | Merial Inc | Ensaio para a produção de circovírus suíno |
| US7691368B2 (en) | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
| RU2389506C2 (ru) | 2005-09-09 | 2010-05-20 | Интервет Интернэшнл Б.В. | Вакцина против рсv-2 |
| RU2488407C2 (ru) | 2005-12-29 | 2013-07-27 | Берингер Ингельхайм Ветмедика, Инк. | Поливалентные иммуногенные композиции pcv2 и способы получения таких композиций |
| DK2371383T3 (en) | 2005-12-29 | 2015-11-30 | Boehringer Ingelheim Vetmed | Use of a PCV2 immunogenic composition for reduction of clinical symptoms in pigs |
| EP2099927A4 (en) | 2006-11-22 | 2010-05-05 | Boehringer Ingelheim Vetmed | Methods of reducing porcine circovirus-associated disease outbreaks |
| US20100129397A1 (en) | 2006-12-11 | 2010-05-27 | Boehringer Ingelheim Vetmedica, Inc. | Effective method of treatment of porcine circovirus and lawsonia intracellularis infections |
| DK2481420T3 (da) * | 2006-12-15 | 2019-05-06 | Boehringer Ingelheim Animal Health Usa Inc | Enkeltdosis-anti-PCV2-svinevaccine |
| EP1941903A1 (en) | 2007-01-03 | 2008-07-09 | Boehringer Ingelheim Vetmedica Gmbh | Prophylaxis and treatment of PRDC |
| EP1958644A1 (en) | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Prevention and treatment of sub-clinical pcvd |
| GB0712160D0 (en) * | 2007-06-22 | 2007-08-01 | Univ Ghent | Methods and compositions in the treatment of procine circoviral infection |
| US20090017064A1 (en) | 2007-07-10 | 2009-01-15 | Wyeth | Methods and Compositions for Immunizing Pigs Against Porcine Circovirus |
| US7829274B2 (en) | 2007-09-04 | 2010-11-09 | Boehringer Ingelheim Vetmedica, Inc. | Reduction of concomitant infections in pigs by the use of PCV2 antigen |
| AU2008343172B2 (en) | 2007-12-21 | 2015-02-19 | Zoetis Services Llc | Methods and compositions for immunizing pigs against porcine circovirus |
| EP2242511A4 (en) | 2008-01-23 | 2012-10-24 | Boehringer Ingelheim Vetmed | IMMUNOGENIC COMPOSITIONS OF MYCOPLASMA HYOPNEUMONIAE PCV2, AND METHODS FOR PRODUCING SUCH COMPOSITIONS |
| WO2009103037A1 (en) | 2008-02-15 | 2009-08-20 | Boehringer Ingelheim Vetmedica, Inc. | Methods and compositions for reducing the impact of enteric diseases |
| US8444989B1 (en) | 2008-04-18 | 2013-05-21 | Boehringer Ingelheim Vetmedica Gmbh | One dose vaccination against mycoplasma infections of pigs |
| TWI627281B (zh) | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | 降低ｐｃｖ－２組合物殺病毒活性之方法及具有改良免疫原性之ｐｃｖ－２組合物 |
| SI2547770T1 (sl) | 2010-03-16 | 2020-07-31 | Virginia Tech Intellectual Properties, Inc. | Vakcina atenuiranega živega himernega prašičjega virusa |
| CN102859875B (zh) | 2010-04-22 | 2016-10-05 | 皇家飞利浦电子股份有限公司 | 皮肤接触检测器 |
| AU2010357208A1 (en) | 2010-07-08 | 2013-02-21 | United Biomedical, Inc. | Designer peptide-based PCV2 vaccine |
| US9580474B2 (en) | 2010-09-08 | 2017-02-28 | The Johns Hopkins University | Polyionic papilloma virus-like particle (VLP) vaccines |
| EP2564869A1 (en) | 2011-09-02 | 2013-03-06 | Ceva Sante Animale | Synthetic capsid proteins and uses thereof |
| CN103122352B (zh) | 2012-09-27 | 2015-02-11 | 华中农业大学 | 一种猪圆环病毒2型重组杆状病毒及制备方法和应用 |
| ES2734374T3 (es) * | 2013-03-01 | 2019-12-05 | Boehringer Ingelheim Animal Health Usa Inc | Cuantificación de composiciones de vacuna |
| CN105246505A (zh) | 2013-04-30 | 2016-01-13 | 勃林格殷格翰动物保健公司 | PCV2a亚型(PCV2a)的ORF2蛋白用于交叉保护中的用途 |
| CN105658660A (zh) | 2013-10-02 | 2016-06-08 | 勃林格殷格翰动物保健公司 | Pcv2 orf2蛋白变体和由其组成的病毒样颗粒 |
| WO2015169732A1 (en) | 2014-05-07 | 2015-11-12 | Boehringer Ingelheim International Gmbh | Container, nebulizer and use |
| CN107531760A (zh) | 2015-03-30 | 2018-01-02 | 勃林格殷格翰动物保健公司 | Pcv2 orf2载体平台 |
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| US20190023747A1 (en) | 2019-01-24 |
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| WO2015051099A1 (en) | 2015-04-09 |
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| US20240076321A1 (en) | 2024-03-07 |
| ES2778425T3 (es) | 2020-08-10 |
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