EA035265B1 - Вариант белка opc2 pcv2 и содержащие его вирусоподобные частицы - Google Patents

Вариант белка opc2 pcv2 и содержащие его вирусоподобные частицы Download PDF

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Publication number
EA035265B1
EA035265B1 EA201600305A EA201600305A EA035265B1 EA 035265 B1 EA035265 B1 EA 035265B1 EA 201600305 A EA201600305 A EA 201600305A EA 201600305 A EA201600305 A EA 201600305A EA 035265 B1 EA035265 B1 EA 035265B1
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Prior art keywords
pcv2
amino acid
residue
protein
opc2
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EA201600305A
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English (en)
Russian (ru)
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EA201600305A1 (ru
Inventor
Луис Алехандро Эрнандес
Кристине Маргарет Мюленталер
Эрик Мартин Вон
Грегори Хайуик
Original Assignee
Бёрингер Ингельхайм Энимал Хелс Ю-Эс-Эй Инк.
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Publication of EA201600305A1 publication Critical patent/EA201600305A1/ru
Publication of EA035265B1 publication Critical patent/EA035265B1/ru

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EA201600305A 2013-10-02 2014-10-02 Вариант белка opc2 pcv2 и содержащие его вирусоподобные частицы EA035265B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361885871P 2013-10-02 2013-10-02
PCT/US2014/058793 WO2015051099A1 (en) 2013-10-02 2014-10-02 Pcv2 orf2 protein variant and virus like particles composed thereof

Publications (2)

Publication Number Publication Date
EA201600305A1 EA201600305A1 (ru) 2016-09-30
EA035265B1 true EA035265B1 (ru) 2020-05-21

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US (6) US9505808B2 (enExample)
EP (1) EP3052516B1 (enExample)
JP (1) JP6778104B2 (enExample)
KR (2) KR20220083861A (enExample)
CN (1) CN105658660A (enExample)
AU (1) AU2014329524B2 (enExample)
CA (1) CA2924228C (enExample)
DK (1) DK3052516T3 (enExample)
EA (1) EA035265B1 (enExample)
ES (1) ES2778425T3 (enExample)
MX (1) MX373884B (enExample)
WO (1) WO2015051099A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
EP3868400A1 (en) 2005-12-29 2021-08-25 Boehringer Ingelheim Animal Health USA Inc. Multivalent pcv2 immunogenic compositions and methods of producing such compositions
US20080181910A1 (en) 2005-12-29 2008-07-31 Boehringer Ingelheim Vetmedica, Inc. Use of a pcv2 immunogenic composition for lessening clinical symptoms in pigs
EP2859900A1 (en) 2006-12-11 2015-04-15 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
EP2242511A4 (en) 2008-01-23 2012-10-24 Boehringer Ingelheim Vetmed IMMUNOGENIC COMPOSITIONS OF MYCOPLASMA HYOPNEUMONIAE PCV2, AND METHODS FOR PRODUCING SUCH COMPOSITIONS
AU2014329524B2 (en) 2013-10-02 2019-01-17 Boehringer Ingelheim Animal Health USA Inc. PCV2 ORF2 protein variant and virus like particles composed thereof
US10555994B2 (en) 2015-03-30 2020-02-11 Boehringer Ingelheim Animal Health USA Inc. PCV2 ORF2 carrier platform
WO2016183423A1 (en) * 2015-05-14 2016-11-17 Merial Inc. Method for porcine circovirus production and pcv2 vaccines
CN104984335A (zh) * 2015-07-14 2015-10-21 浙江诺倍威生物技术有限公司 猪圆环病毒双亚型orf2共表达载体构建及疫苗制备
EP3426293A4 (en) * 2016-03-07 2019-10-30 Virginia Tech Intellectual Properties, Inc. CHIMERIC VACCINES AGAINST PORCINE CIRCOVIRUS TYPE 2 (PCV2)
US10431889B2 (en) * 2016-04-22 2019-10-01 The Charles Stark Draper Laboratory, Inc. Low-loss compact transmit impedance matching tuning technique
CN106399350B (zh) * 2016-09-07 2020-02-21 复旦大学 一种猪圆环病毒ii型病毒样颗粒疫苗及其制备方法
CN106399138B (zh) * 2016-09-07 2019-11-12 复旦大学 猪圆环病毒ii型口服病毒样颗粒疫苗及其制备方法和应用
JP6876127B2 (ja) * 2016-11-03 2021-05-26 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーBoehringer Ingelheim Vetmedica GmbH ブタパルボウイルスに対するワクチン
CN106834242B (zh) * 2017-03-02 2021-02-23 扬州大学 嵌合型猪圆环病毒活疫苗c1-233株及其构建方法
CN106834241B (zh) * 2017-03-02 2021-01-19 扬州大学 嵌合型猪圆环病毒活疫苗c1-402株及其构建方法
CN107245477B (zh) * 2017-06-06 2020-06-30 广东海大畜牧兽医研究院有限公司 一种猪圆环病毒2型病毒样颗粒的制备方法及通过该方法获得的病毒样颗粒
JP7062760B2 (ja) 2017-10-17 2022-05-06 インターベット インターナショナル ベー. フェー. 昆虫細胞でのPCV2b ORF2タンパク質の組換え発現
CN108484725A (zh) * 2018-03-16 2018-09-04 广东海大畜牧兽医研究院有限公司 一种区分检测pcv2野毒抗体与疫苗抗体的多肽及其在elisa检测试剂盒中的应用
CN110358742B (zh) * 2019-07-05 2020-12-22 武汉科前生物股份有限公司 猪圆环病毒2b型和2d型的二价亚单位疫苗及其制备方法
CN111415356B (zh) * 2020-03-17 2020-12-29 推想医疗科技股份有限公司 肺炎征象的分割方法、装置、介质及电子设备
CN112010949B (zh) * 2020-08-03 2021-07-27 山东绿都生物科技有限公司 一种重组pcv2病毒样颗粒蜂胶疫苗及其制备方法
CN114250259B (zh) * 2020-09-21 2024-07-19 成都史纪生物制药有限公司 一种猪圆环2型病毒Cap蛋白病毒样颗粒的发酵培养基
TWI867524B (zh) * 2022-05-09 2024-12-21 福又達生物科技股份有限公司 豬環狀病毒第二型及豬瘟病毒次單位雙價疫苗
AR132581A1 (es) 2023-05-03 2025-07-16 Boehringer Ingelheim Vetmedica Gmbh Composición inmunógena útil para la autoadministración por cerdos
TW202508619A (zh) 2023-05-03 2025-03-01 德商百靈佳殷格翰維美迪加股份有限公司 用於誘導免疫反應之方法
CN118063562B (zh) * 2024-03-11 2025-04-01 天康生物制药有限公司 优化的猪圆环病毒2型Cap蛋白及其病毒样颗粒和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008076915A2 (en) * 2006-12-15 2008-06-26 Boehringer Ingelheim Vetmedica, Inc. Treatment of pigs with pcv2 antigen
WO2014134561A2 (en) * 2013-03-01 2014-09-04 Boehringer Ingelheim Vetmedica, Inc. Quantification of vaccine compositions

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909462A (en) 1955-12-08 1959-10-20 Bristol Myers Co Acrylic acid polymer laxative compositions
ZA881694B (en) 1987-03-17 1988-09-06 Akzo N.V. Adjuvant mixture
US5069901A (en) 1988-02-03 1991-12-03 Jones Elaine V Preparation of a recombinant subunit vaccine against pseudorabies infection
WO1990007935A1 (en) 1989-01-23 1990-07-26 Auspharm International Ltd. Vaccine composition
US5155037A (en) 1989-08-04 1992-10-13 The Texas A&M University System Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems
US5202430A (en) 1990-01-16 1993-04-13 University Of Tennessee Transmissible gastroenteritis virus genes
EP0597852B2 (en) 1990-05-29 2005-08-10 Wyeth Holdings Corporation Swine pneumonia vaccine and method for the preparation thereof
US5565205A (en) 1990-08-16 1996-10-15 Solvay Animal Health, Inc. Inactivated Mycoplasma hypopneumoniae bacterin and method of use thereof
GB9023111D0 (en) 1990-10-24 1990-12-05 Wellcome Found Expression system
ES2150419T3 (es) 1990-11-01 2000-12-01 Univ Iowa State Res Found Inc Procedimiento de atenuacion bacteriana y vacuna.
CA2076744C (en) 1991-08-26 2000-06-27 Danny W. Chladek Viral agent associated with mystery swine disease
US6042830A (en) 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
US5580557A (en) 1991-10-09 1996-12-03 Iowa State University Research Foundation, Inc. Live, avirulent salmonella choleraesuis vaccine used for inducing an immune response in animals
US5338543A (en) 1992-02-27 1994-08-16 Ambico, Inc. Thimerosal inactivated mycoplasma hyopneumoniae vaccine
PT968722E (pt) 1994-05-10 2007-09-06 Wyeth Corp Vacina viva melhorada contra brsv.
US5885823A (en) 1995-06-05 1999-03-23 Nobl Laboratories, Inc. Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents
AU4231897A (en) 1996-08-16 1998-03-06 Southwest Foundation For Biomedical Research Compositions and methods for delivery of nucleic acids to hepatocytes
DK0835930T3 (da) 1996-10-09 2001-06-18 Akzo Nobel Nv Europæiske vaccinestammer af porcint reproduktions- og respirationssyndrom-virus. (PRRSV)
US20060029617A1 (en) 1997-10-03 2006-02-09 Charreyre Catherine E Porcine circovirus and Helicobacter combination vaccines and methods of use
UA78180C2 (uk) 1997-10-03 2007-03-15 Меріаль Кільцевий вірус свині типу ii, вакцини та діагностичні реагенти
FR2781159B1 (fr) 1998-07-06 2000-10-06 Merial Sas Vaccin circovirus et parvovirus porcin
US7211379B2 (en) 1997-10-03 2007-05-01 Merial Sas Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2
US6517843B1 (en) 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
US6391314B1 (en) 1997-10-03 2002-05-21 Merial Porcine circoviruses vaccines diagnostic reagents
US7192594B2 (en) 1997-10-03 2007-03-20 Merial Limited Postweaning multisystemic wasting syndrome and porcine circovirus from pigs
FR2772047B1 (fr) 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
US20040062775A1 (en) 1997-12-05 2004-04-01 Agence Francaise De Securite Sanitaire Des Aliments Circovirus sequences associated with piglet weight loss disease (PWD)
DE69837934T2 (de) 1997-12-11 2008-02-21 University Of Saskatchewan, Saskatoon Multisystemisches kümmerwuchssyndrom durch viren in schweinen
US6287856B1 (en) 1998-03-13 2001-09-11 University Of Georgia Research Foundation, Inc. Vaccines against circovirus infections
EP0953574A1 (en) * 1998-04-30 1999-11-03 Innogenetics N.V. Immunodiagnostic reagent for the detection of Maedi-Visna virus and CAEV infection
US6294176B1 (en) 1998-07-10 2001-09-25 Schering-Plough Veterinary Corp. Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species
US6472193B1 (en) 1998-11-19 2002-10-29 Azwell Inc. Recombinant lysophosphatidic acid phosphatase
FR2789695B1 (fr) 1999-02-11 2003-03-07 Merial Sas Vecteurs et vaccins viraux a base d'adenovirus porcins recombines et replicatifs
US6497883B1 (en) 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
US6943152B1 (en) 1999-06-10 2005-09-13 Merial DNA vaccine-PCV
WO2001017556A1 (fr) 1999-09-07 2001-03-15 Shionogi & Co., Ltd. Préparations vaccinales administrables par les muqueuses
US6656478B1 (en) 1999-11-12 2003-12-02 Samuel D. Charles Cross-protective salmonella vaccines
DE60038048T2 (de) 1999-12-21 2009-07-09 Merial Mindestens ein cryptosporidium parvum-antigen und mindestens ein antigen eines anderen darmkrankheitserregers enthaltende zusammensetzungen und impfstoffe
US6808900B2 (en) 2000-06-15 2004-10-26 Manitoba, University Of Cryptosporidium parvum antigens, antibodies thereto and diagnostic and therapeutic compositions thereof
MXPA02012352A (es) 2000-06-15 2004-09-06 Purdue Research Foundation Vacuna para temblores congenitos en cerdos.
MY129765A (en) 2000-12-19 2007-04-30 Wyeth Corp Improved mycoplasma hyopneumoniae bacterin vaccine
US7018638B2 (en) 2000-12-19 2006-03-28 Wyeth Mycoplasma hyopneumoniae bacterin vaccine
JP2002247979A (ja) 2001-02-23 2002-09-03 Nippon Biologicals Inc マレック病ワクチンおよびその製造方法
WO2002077210A2 (en) 2001-03-27 2002-10-03 University Of Saskatchewan Methods to culture circovirus
US20030096377A1 (en) 2001-06-28 2003-05-22 Virginia Tech Intellectual Properties, Inc. Differential PCR-RFLP assay for detecting and distinguishing between nonpathogenic PCV-1 and pathogenic PCV-2
EA009901B1 (ru) 2001-07-02 2008-04-28 Пфайзер Продактс Инк. Способ лечения или предупреждения заболевания или нарушения у животного, вызванного mycoplasma hyopneumoniae
US7361352B2 (en) 2001-08-15 2008-04-22 Acambis, Inc. Influenza immunogen and vaccine
US7276353B2 (en) 2001-12-12 2007-10-02 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US7279166B2 (en) 2001-12-12 2007-10-09 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US6841364B2 (en) 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
WO2003068993A1 (en) 2002-02-14 2003-08-21 Novavax, Inc. Method for isolation and purification of expressed gene products in vitro
US20030199581A1 (en) 2002-03-13 2003-10-23 Seligson Allen L. Boswellin compositions enhanced with 3-beta-acetyl-11-keto-beta-boswellic acid ("AKBA") industrial manufacture and uses
US20030215455A1 (en) 2002-05-14 2003-11-20 Bailey Reynolds Vaccine stabilizer and method of use
AU2002951692A0 (en) 2002-09-23 2002-10-17 Vital Biotech (Hong Kong) Limited Improvements in or relating to vaccines
HUE026171T2 (en) 2003-02-03 2016-05-30 Cerebus Biologicals Inc A method for treating, preventing and detecting Helicobacter infection
US7563449B2 (en) 2003-04-21 2009-07-21 Pfizer Inc, Methods for reducing cattle reproductive diseases
CN1458167A (zh) 2003-06-02 2003-11-26 中国农业科学院哈尔滨兽医研究所 截短表达的猪圆环病毒ⅱ型衣壳蛋白抗原及其应用
US7335361B2 (en) 2003-06-09 2008-02-26 Animal Technology Institute Taiwan Fusion antigen used as vaccine
ES2307053T3 (es) 2003-07-24 2008-11-16 Merial Limited Formulaciones de vacuna que comprenden una emulsion de aceite en agua.
SI1651260T2 (sl) 2003-07-25 2018-09-28 Boehringer Ingelheim Vetmedica, Inc. Lawsonia intracellularis evropskega izvora in vakcine, diagnostična sredstva in postopki za njihovo uporabo
FR2861731B1 (fr) 2003-10-30 2006-02-24 Centre Nat Rech Scient Nouvelle proteine de fixation du phosphate, compositions pharmaceutiques la contenant et ses utilisations
WO2005112995A1 (en) 2004-04-26 2005-12-01 Choongang Vaccine Laboratory Co., Ltd. Inactivated mixed vaccine for porcine respiratory disease and the method of manufacturing thereof
CN1579553A (zh) 2004-05-18 2005-02-16 浙江大学 Ii型猪圆环病毒核酸疫苗的制备方法及其应用
EP1778283A2 (en) 2004-06-30 2007-05-02 ID Biomedical Corporation of Quebec Vaccine compositions for treating coronavirus infection
US7833707B2 (en) 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
US7700285B1 (en) 2005-12-29 2010-04-20 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
RU2007130801A (ru) 2005-01-13 2009-02-20 Берингер Ингельхайм Ветмедика Гмбх (De) Улучшенные вакцины против репродуктивно-респираторного синдрома свиней (prrs)
US7300785B2 (en) 2005-02-03 2007-11-27 Universiteit Ghent Culturing circular ssDNA viruses for the production of vaccines
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
JP5408998B2 (ja) 2005-04-13 2014-02-05 メリアル リミテッド ブタサーコウイルス産生アッセイ
US7691368B2 (en) 2005-04-15 2010-04-06 Merial Limited Vaccine formulations
BRPI0615862A2 (pt) 2005-09-09 2011-05-31 Intervet Int Bv vacina contra pcv-2, e, método para a manufatura de uma vacina
EP3868400A1 (en) 2005-12-29 2021-08-25 Boehringer Ingelheim Animal Health USA Inc. Multivalent pcv2 immunogenic compositions and methods of producing such compositions
US20080181910A1 (en) 2005-12-29 2008-07-31 Boehringer Ingelheim Vetmedica, Inc. Use of a pcv2 immunogenic composition for lessening clinical symptoms in pigs
EP2099927A4 (en) 2006-11-22 2010-05-05 Boehringer Ingelheim Vetmed Methods of reducing porcine circovirus-associated disease outbreaks
EP2859900A1 (en) 2006-12-11 2015-04-15 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
GB0712160D0 (en) * 2007-06-22 2007-08-01 Univ Ghent Methods and compositions in the treatment of procine circoviral infection
US20090017064A1 (en) 2007-07-10 2009-01-15 Wyeth Methods and Compositions for Immunizing Pigs Against Porcine Circovirus
US7829274B2 (en) 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
AU2008343172B2 (en) 2007-12-21 2015-02-19 Zoetis Services Llc Methods and compositions for immunizing pigs against porcine circovirus
EP2242511A4 (en) 2008-01-23 2012-10-24 Boehringer Ingelheim Vetmed IMMUNOGENIC COMPOSITIONS OF MYCOPLASMA HYOPNEUMONIAE PCV2, AND METHODS FOR PRODUCING SUCH COMPOSITIONS
WO2009103037A1 (en) 2008-02-15 2009-08-20 Boehringer Ingelheim Vetmedica, Inc. Methods and compositions for reducing the impact of enteric diseases
US8444989B1 (en) 2008-04-18 2013-05-21 Boehringer Ingelheim Vetmedica Gmbh One dose vaccination against mycoplasma infections of pigs
AR078253A1 (es) 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
ES2773722T3 (es) 2010-03-16 2020-07-14 Virginia Tech Intellectual Properties Inc Vacuna de circovirus porcino quimérico atenuado vivo
CN102859875B (zh) 2010-04-22 2016-10-05 皇家飞利浦电子股份有限公司 皮肤接触检测器
CN103108653B (zh) 2010-07-08 2015-07-22 美国联合生物医学公司 设计肽的pcv2疫苗
US9580474B2 (en) 2010-09-08 2017-02-28 The Johns Hopkins University Polyionic papilloma virus-like particle (VLP) vaccines
EP2564869A1 (en) 2011-09-02 2013-03-06 Ceva Sante Animale Synthetic capsid proteins and uses thereof
CN103122352B (zh) 2012-09-27 2015-02-11 华中农业大学 一种猪圆环病毒2型重组杆状病毒及制备方法和应用
EP2991676A1 (en) 2013-04-30 2016-03-09 Boehringer Ingelheim Vetmedica, Inc. Orf2 protein of pcv2 subtype a (pcv2a) for use in cross-protection
AU2014329524B2 (en) 2013-10-02 2019-01-17 Boehringer Ingelheim Animal Health USA Inc. PCV2 ORF2 protein variant and virus like particles composed thereof
KR102443737B1 (ko) 2014-05-07 2022-09-19 베링거 인겔하임 인터내셔날 게엠베하 컨테이너, 분무기 및 사용 방법
US10555994B2 (en) * 2015-03-30 2020-02-11 Boehringer Ingelheim Animal Health USA Inc. PCV2 ORF2 carrier platform

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008076915A2 (en) * 2006-12-15 2008-06-26 Boehringer Ingelheim Vetmedica, Inc. Treatment of pigs with pcv2 antigen
WO2014134561A2 (en) * 2013-03-01 2014-09-04 Boehringer Ingelheim Vetmedica, Inc. Quantification of vaccine compositions

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, 1 January 2008, Columbus, Ohio, US; WANG HAIYAN, GAO SONG, LIU XIUFAN: "Isolation and identification of porcine circovirus type 2 virus from a domesticated wild boar" XP002734028 *
DATABASE EMBL [online] "Porcine circovirus-2 partial capsid protein", XP002734030, retrieved from EBI *
DATABASE EMBL [online] E.B.I. Hinxton U.K.; "Porcine circovirus-2 capsid protein", XP002734027, retrieved from EBI *
DATABASE EMBL [online] E.B.I. Hinxton U.K.; "Porcine circovirus-2 capsid protein", XP002734029, retrieved from EBI *
NAWAGITGUL P, ET AL.: "Open reading frame 2 of porcine circovirus type 2 encodes a major capsid protein", JOURNAL OF GENERAL VIROLOGY., SOCIETY FOR GENERAL MICROBIOLOGY, SPENCERS WOOD., GB, vol. 81, no. 9, 1 January 2000 (2000-01-01), GB, pages 2281 - 2287, XP002978778, ISSN: 0022-1317 *

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