EA201600305A1 - Вариант белка opc2 pcv2 и содержащие его вирусоподобные частицы - Google Patents
Вариант белка opc2 pcv2 и содержащие его вирусоподобные частицыInfo
- Publication number
- EA201600305A1 EA201600305A1 EA201600305A EA201600305A EA201600305A1 EA 201600305 A1 EA201600305 A1 EA 201600305A1 EA 201600305 A EA201600305 A EA 201600305A EA 201600305 A EA201600305 A EA 201600305A EA 201600305 A1 EA201600305 A1 EA 201600305A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pcv2
- subtype
- pcv2b
- opc2
- infection
- Prior art date
Links
- 241001673669 Porcine circovirus 2 Species 0.000 title abstract 9
- 239000002245 particle Substances 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 229910004667 OPV2 Inorganic materials 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- 102000016304 Origin Recognition Complex Human genes 0.000 abstract 1
- 108010067244 Origin Recognition Complex Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
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- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61K2039/5258—Virus-like particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- C12N2710/14011—Baculoviridae
- C12N2710/14041—Use of virus, viral particle or viral elements as a vector
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- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
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Abstract
В заявке описаны способы вакцинации для контроля заражения PCV2 с помощью различных подтипов PCV2. В частности, белки ОРС2 PCV2 подтипа b (PCV2b) или иммуногенные композиции, содержащие белок ОРС2 PCV2b применяют в способе лечения или предупреждения заражения с помощью PCV2 такого же PCV2b-подтипа и/или другого подтипа; в способе снижения, предупреждения или лечения клинических признаков, вызываемых инфекцией, с помощью PCV2 такого же PCV2b-подтипа и/или другого подтипа; и/или в способе предупреждения или лечения заболевания, вызываемого инфекцией, с помощью PCV2 такого же PCV2b-подтипа и/или другого подтипа. В настоящей заявке описаны также белки ОРС2 PCV2 подтипа b (PCV2b), отличающиеся тем, что они содержат по меньшей мере одну мутацию в ВС-петле, в результате которой экспрессируемый белок предпочтительно экспрессируется в более высоком количестве по сравнению с белком ОРС2 PCV2, который не содержит указанную мутацию.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361885871P | 2013-10-02 | 2013-10-02 | |
PCT/US2014/058793 WO2015051099A1 (en) | 2013-10-02 | 2014-10-02 | Pcv2 orf2 protein variant and virus like particles composed thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201600305A1 true EA201600305A1 (ru) | 2016-09-30 |
EA035265B1 EA035265B1 (ru) | 2020-05-21 |
Family
ID=51795768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201600305A EA035265B1 (ru) | 2013-10-02 | 2014-10-02 | Вариант белка opc2 pcv2 и содержащие его вирусоподобные частицы |
Country Status (12)
Country | Link |
---|---|
US (5) | US9505808B2 (ru) |
EP (1) | EP3052516B1 (ru) |
JP (1) | JP6778104B2 (ru) |
KR (2) | KR20220083861A (ru) |
CN (1) | CN105658660A (ru) |
AU (1) | AU2014329524B2 (ru) |
CA (1) | CA2924228C (ru) |
DK (1) | DK3052516T3 (ru) |
EA (1) | EA035265B1 (ru) |
ES (1) | ES2778425T3 (ru) |
MX (1) | MX2016004063A (ru) |
WO (1) | WO2015051099A1 (ru) |
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PL1968630T3 (pl) | 2005-12-29 | 2018-08-31 | Boehringer Ingelheim Vetmedica, Inc. | Multiwalentne immunogenne kompozycje PCV2 |
CN104383526B (zh) | 2005-12-29 | 2018-09-18 | 贝林格尔.英格海姆维特梅迪卡有限公司 | Pcv2免疫原性组合物用于减轻猪临床症状的用途 |
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EP2242511A4 (en) | 2008-01-23 | 2012-10-24 | Boehringer Ingelheim Vetmed | IMMUNOGENIC COMPOSITIONS OF MYCOPLASMA HYOPNEUMONIAE PCV2, AND METHODS FOR PRODUCING SUCH COMPOSITIONS |
EA035265B1 (ru) * | 2013-10-02 | 2020-05-21 | Бёрингер Ингельхайм Энимал Хелс Ю-Эс-Эй Инк. | Вариант белка opc2 pcv2 и содержащие его вирусоподобные частицы |
CN107531760A (zh) * | 2015-03-30 | 2018-01-02 | 勃林格殷格翰动物保健公司 | Pcv2 orf2载体平台 |
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CN106399138B (zh) * | 2016-09-07 | 2019-11-12 | 复旦大学 | 猪圆环病毒ii型口服病毒样颗粒疫苗及其制备方法和应用 |
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CN106834242B (zh) * | 2017-03-02 | 2021-02-23 | 扬州大学 | 嵌合型猪圆环病毒活疫苗c1-233株及其构建方法 |
CN106834241B (zh) * | 2017-03-02 | 2021-01-19 | 扬州大学 | 嵌合型猪圆环病毒活疫苗c1-402株及其构建方法 |
CN107245477B (zh) * | 2017-06-06 | 2020-06-30 | 广东海大畜牧兽医研究院有限公司 | 一种猪圆环病毒2型病毒样颗粒的制备方法及通过该方法获得的病毒样颗粒 |
WO2019076864A1 (en) * | 2017-10-17 | 2019-04-25 | Intervet International B.V. | RECOMBINANT EXPRESSION OF PCV2B ORF2 PROTEIN IN INSECT CELLS |
CN108484725A (zh) * | 2018-03-16 | 2018-09-04 | 广东海大畜牧兽医研究院有限公司 | 一种区分检测pcv2野毒抗体与疫苗抗体的多肽及其在elisa检测试剂盒中的应用 |
CN110358742B (zh) * | 2019-07-05 | 2020-12-22 | 武汉科前生物股份有限公司 | 猪圆环病毒2b型和2d型的二价亚单位疫苗及其制备方法 |
CN111415356B (zh) * | 2020-03-17 | 2020-12-29 | 推想医疗科技股份有限公司 | 肺炎征象的分割方法、装置、介质及电子设备 |
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JP2016534034A (ja) | 2016-11-04 |
KR102409183B1 (ko) | 2022-06-15 |
ES2778425T3 (es) | 2020-08-10 |
CN105658660A (zh) | 2016-06-08 |
MX2016004063A (es) | 2016-06-06 |
AU2014329524A1 (en) | 2016-03-17 |
JP6778104B2 (ja) | 2020-10-28 |
AU2014329524B2 (en) | 2019-01-17 |
KR20220083861A (ko) | 2022-06-20 |
US20170029471A1 (en) | 2017-02-02 |
CA2924228A1 (en) | 2015-04-09 |
DK3052516T3 (da) | 2020-03-23 |
US20240076321A1 (en) | 2024-03-07 |
CA2924228C (en) | 2024-01-16 |
US20150093404A1 (en) | 2015-04-02 |
US20210221852A1 (en) | 2021-07-22 |
US11858963B2 (en) | 2024-01-02 |
KR20160058958A (ko) | 2016-05-25 |
US9505808B2 (en) | 2016-11-29 |
US20190023747A1 (en) | 2019-01-24 |
EP3052516A1 (en) | 2016-08-10 |
EA035265B1 (ru) | 2020-05-21 |
EP3052516B1 (en) | 2020-01-01 |
WO2015051099A1 (en) | 2015-04-09 |
US10961281B2 (en) | 2021-03-30 |
US10131696B2 (en) | 2018-11-20 |
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