KR102409183B1 - Ｐｃｖ2 ｏｒｆ2 단백질 변이체 및 이로 이루어진 바이러스 유사 입자 - Google Patents

Ｐｃｖ2 ｏｒｆ2 단백질 변이체 및 이로 이루어진 바이러스 유사 입자 Download PDF

Info

Publication number
KR102409183B1
KR102409183B1 KR1020167011660A KR20167011660A KR102409183B1 KR 102409183 B1 KR102409183 B1 KR 102409183B1 KR 1020167011660 A KR1020167011660 A KR 1020167011660A KR 20167011660 A KR20167011660 A KR 20167011660A KR 102409183 B1 KR102409183 B1 KR 102409183B1
Authority
KR
South Korea
Prior art keywords
pcv2
amino acid
residue
arg
orf2 protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020167011660A
Other languages
English (en)
Korean (ko)
Other versions
KR20160058958A (ko
Inventor
루이스 알레한드로 헤르난데즈
크리스틴 마가렛 뮐렌탈러
에릭 마틴 보겐
그레고리 해이위크
Original Assignee
베링거 인겔하임 애니멀 헬스 유에스에이 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 베링거 인겔하임 애니멀 헬스 유에스에이 인크. filed Critical 베링거 인겔하임 애니멀 헬스 유에스에이 인크.
Priority to KR1020227019654A priority Critical patent/KR20220083861A/ko
Publication of KR20160058958A publication Critical patent/KR20160058958A/ko
Application granted granted Critical
Publication of KR102409183B1 publication Critical patent/KR102409183B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020167011660A 2013-10-02 2014-10-02 Ｐｃｖ2 ｏｒｆ2 단백질 변이체 및 이로 이루어진 바이러스 유사 입자 Active KR102409183B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227019654A KR20220083861A (ko) 2013-10-02 2014-10-02 Ｐｃｖ2 ｏｒｆ2 단백질 변이체 및 이로 이루어진 바이러스 유사 입자

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361885871P 2013-10-02 2013-10-02
US61/885,871 2013-10-02
PCT/US2014/058793 WO2015051099A1 (en) 2013-10-02 2014-10-02 Pcv2 orf2 protein variant and virus like particles composed thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020227019654A Division KR20220083861A (ko) 2013-10-02 2014-10-02 Ｐｃｖ2 ｏｒｆ2 단백질 변이체 및 이로 이루어진 바이러스 유사 입자

Publications (2)

Publication Number Publication Date
KR20160058958A KR20160058958A (ko) 2016-05-25
KR102409183B1 true KR102409183B1 (ko) 2022-06-15

Family

ID=51795768

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020167011660A Active KR102409183B1 (ko) 2013-10-02 2014-10-02 Ｐｃｖ2 ｏｒｆ2 단백질 변이체 및 이로 이루어진 바이러스 유사 입자
KR1020227019654A Ceased KR20220083861A (ko) 2013-10-02 2014-10-02 Ｐｃｖ2 ｏｒｆ2 단백질 변이체 및 이로 이루어진 바이러스 유사 입자

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020227019654A Ceased KR20220083861A (ko) 2013-10-02 2014-10-02 Ｐｃｖ2 ｏｒｆ2 단백질 변이체 및 이로 이루어진 바이러스 유사 입자

Country Status (12)

Country Link
US (6) US9505808B2 (enExample)
EP (1) EP3052516B1 (enExample)
JP (1) JP6778104B2 (enExample)
KR (2) KR102409183B1 (enExample)
CN (1) CN105658660A (enExample)
AU (1) AU2014329524B2 (enExample)
CA (1) CA2924228C (enExample)
DK (1) DK3052516T3 (enExample)
EA (1) EA035265B1 (enExample)
ES (1) ES2778425T3 (enExample)
MX (1) MX373884B (enExample)
WO (1) WO2015051099A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
HUE025994T2 (en) 2005-12-29 2016-05-30 Boehringer Ingelheim Vetmedica Inc Use of PCV2 immunogenic composition to reduce clinical symptoms in piglets
EP1968630B1 (en) 2005-12-29 2018-01-24 Boehringer Ingelheim Vetmedica, Inc. Multivalent pcv2 immunogenic compositions
WO2008073464A2 (en) 2006-12-11 2008-06-19 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
WO2009126356A2 (en) 2008-01-23 2009-10-15 Boehringer Ingelheim Vetmedica, Inc. Pcv2 mycoplasma hyopneumoniae immunogenic compositions and methods of producing such compositions
MX373884B (es) 2013-10-02 2020-03-26 Boehringer Ingelheim Animal Health Usa Inc Variante de la proteína pcv2 orf2 y partículas similares al virus compuestas por ésta.
US10555994B2 (en) * 2015-03-30 2020-02-11 Boehringer Ingelheim Animal Health USA Inc. PCV2 ORF2 carrier platform
EP3294876A1 (en) * 2015-05-14 2018-03-21 Merial, Inc. Method for porcine circovirus production and pcv2 vaccines
CN104984335A (zh) * 2015-07-14 2015-10-21 浙江诺倍威生物技术有限公司 猪圆环病毒双亚型orf2共表达载体构建及疫苗制备
KR20190017725A (ko) * 2016-03-07 2019-02-20 버지니아 테크 인터렉추얼 프라퍼티스, 인크. 키메라 돼지 써코바이러스 유형 2 (pcv2) 백신
US10431889B2 (en) * 2016-04-22 2019-10-01 The Charles Stark Draper Laboratory, Inc. Low-loss compact transmit impedance matching tuning technique
CN106399350B (zh) * 2016-09-07 2020-02-21 复旦大学 一种猪圆环病毒ii型病毒样颗粒疫苗及其制备方法
CN106399138B (zh) * 2016-09-07 2019-11-12 复旦大学 猪圆环病毒ii型口服病毒样颗粒疫苗及其制备方法和应用
EA201991065A1 (ru) * 2016-11-03 2019-11-29 Вакцина против свиного парвовируса
CN106834242B (zh) * 2017-03-02 2021-02-23 扬州大学 嵌合型猪圆环病毒活疫苗c1-233株及其构建方法
CN106834241B (zh) * 2017-03-02 2021-01-19 扬州大学 嵌合型猪圆环病毒活疫苗c1-402株及其构建方法
CN107245477B (zh) * 2017-06-06 2020-06-30 广东海大畜牧兽医研究院有限公司 一种猪圆环病毒2型病毒样颗粒的制备方法及通过该方法获得的病毒样颗粒
EP3697804B1 (en) 2017-10-17 2023-08-23 Intervet International B.V. Recombinant expression of pcv2b orf2 protein in insect cells
CN108484725A (zh) * 2018-03-16 2018-09-04 广东海大畜牧兽医研究院有限公司 一种区分检测pcv2野毒抗体与疫苗抗体的多肽及其在elisa检测试剂盒中的应用
CN110358742B (zh) * 2019-07-05 2020-12-22 武汉科前生物股份有限公司 猪圆环病毒2b型和2d型的二价亚单位疫苗及其制备方法
CN111415356B (zh) * 2020-03-17 2020-12-29 推想医疗科技股份有限公司 肺炎征象的分割方法、装置、介质及电子设备
CN112010949B (zh) * 2020-08-03 2021-07-27 山东绿都生物科技有限公司 一种重组pcv2病毒样颗粒蜂胶疫苗及其制备方法
CN114250259B (zh) * 2020-09-21 2024-07-19 成都史纪生物制药有限公司 一种猪圆环2型病毒Cap蛋白病毒样颗粒的发酵培养基
TWI867523B (zh) * 2022-05-09 2024-12-21 福又達生物科技股份有限公司 豬環狀病毒第二型次單位疫苗
AU2024265654A1 (en) 2023-05-03 2025-12-04 Boehringer Ingelheim Vetmedica Gmbh Method for inducing an immune response
TW202509055A (zh) 2023-05-03 2025-03-01 德商百靈佳殷格翰維美迪加股份有限公司 用於豬隻自身給藥之免疫原性組合物
CN118063562B (zh) * 2024-03-11 2025-04-01 天康生物制药有限公司 优化的猪圆环病毒2型Cap蛋白及其病毒样颗粒和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100184016A1 (en) * 2007-06-22 2010-07-22 David Jacques Gerard Lefebvre Methods and compositions in the treatment of porcine circoviral infection

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909462A (en) 1955-12-08 1959-10-20 Bristol Myers Co Acrylic acid polymer laxative compositions
ZA881694B (en) 1987-03-17 1988-09-06 Akzo N.V. Adjuvant mixture
US5069901A (en) 1988-02-03 1991-12-03 Jones Elaine V Preparation of a recombinant subunit vaccine against pseudorabies infection
DE69027112T2 (de) 1989-01-23 1997-01-09 Auspharm International Ltd 4Th Impfstoffzusammensetzung
US5155037A (en) 1989-08-04 1992-10-13 The Texas A&M University System Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems
US5202430A (en) 1990-01-16 1993-04-13 University Of Tennessee Transmissible gastroenteritis virus genes
DK0597852T4 (da) 1990-05-29 2005-10-17 Wyeth Corp Svinepneumonivaccine og fremgangsmåde til fremstilling deraf
US5565205A (en) 1990-08-16 1996-10-15 Solvay Animal Health, Inc. Inactivated Mycoplasma hypopneumoniae bacterin and method of use thereof
GB9023111D0 (en) 1990-10-24 1990-12-05 Wellcome Found Expression system
ES2150419T3 (es) 1990-11-01 2000-12-01 Univ Iowa State Res Found Inc Procedimiento de atenuacion bacteriana y vacuna.
US6042830A (en) 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
MX9204885A (es) 1991-08-26 1994-05-31 Boehringer Animal Health Inc Composicion de vacuna que comprende virus del sindrome de infertilidad y respiratorio de los cerdos.
US5580557A (en) 1991-10-09 1996-12-03 Iowa State University Research Foundation, Inc. Live, avirulent salmonella choleraesuis vaccine used for inducing an immune response in animals
US5338543A (en) 1992-02-27 1994-08-16 Ambico, Inc. Thimerosal inactivated mycoplasma hyopneumoniae vaccine
EP0968722B1 (en) 1994-05-10 2007-06-20 Wyeth Improved modified live BRSV vaccine
US5885823A (en) 1995-06-05 1999-03-23 Nobl Laboratories, Inc. Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents
US5888532A (en) 1996-08-16 1999-03-30 Pritsos; Chris A. Treatment of alcoholism and related disorders with (nicotinamide-adenine dinucleotide) phosphate derivatives
DK0835930T3 (da) 1996-10-09 2001-06-18 Akzo Nobel Nv Europæiske vaccinestammer af porcint reproduktions- og respirationssyndrom-virus. (PRRSV)
UA78180C2 (uk) 1997-10-03 2007-03-15 Меріаль Кільцевий вірус свині типу ii, вакцини та діагностичні реагенти
FR2781159B1 (fr) 1998-07-06 2000-10-06 Merial Sas Vaccin circovirus et parvovirus porcin
US6391314B1 (en) 1997-10-03 2002-05-21 Merial Porcine circoviruses vaccines diagnostic reagents
US7192594B2 (en) 1997-10-03 2007-03-20 Merial Limited Postweaning multisystemic wasting syndrome and porcine circovirus from pigs
US20060029617A1 (en) 1997-10-03 2006-02-09 Charreyre Catherine E Porcine circovirus and Helicobacter combination vaccines and methods of use
US7211379B2 (en) 1997-10-03 2007-05-01 Merial Sas Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2
US6517843B1 (en) 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
US20040062775A1 (en) 1997-12-05 2004-04-01 Agence Francaise De Securite Sanitaire Des Aliments Circovirus sequences associated with piglet weight loss disease (PWD)
FR2772047B1 (fr) 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
ES2289796T3 (es) 1997-12-11 2008-02-01 University Of Saskatchewan Virus del sindrome del desmedro post-destete procedente de cerdos.
US6287856B1 (en) 1998-03-13 2001-09-11 University Of Georgia Research Foundation, Inc. Vaccines against circovirus infections
EP0953574A1 (en) * 1998-04-30 1999-11-03 Innogenetics N.V. Immunodiagnostic reagent for the detection of Maedi-Visna virus and CAEV infection
US6294176B1 (en) 1998-07-10 2001-09-25 Schering-Plough Veterinary Corp. Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species
EP1050584B1 (en) 1998-11-19 2006-10-18 Azwell Inc. Recombinant lysophosphatidic acid phosphatase
FR2789695B1 (fr) 1999-02-11 2003-03-07 Merial Sas Vecteurs et vaccins viraux a base d'adenovirus porcins recombines et replicatifs
US6497883B1 (en) 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
US6943152B1 (en) 1999-06-10 2005-09-13 Merial DNA vaccine-PCV
WO2001017556A1 (fr) 1999-09-07 2001-03-15 Shionogi & Co., Ltd. Préparations vaccinales administrables par les muqueuses
US6656478B1 (en) 1999-11-12 2003-12-02 Samuel D. Charles Cross-protective salmonella vaccines
JP2003518073A (ja) 1999-12-21 2003-06-03 メリアル クリプトスポリジウムパルヴァムと他の腸内病原体の抗原を含む組成物およびワクチン
US6808900B2 (en) 2000-06-15 2004-10-26 Manitoba, University Of Cryptosporidium parvum antigens, antibodies thereto and diagnostic and therapeutic compositions thereof
JP2004503234A (ja) 2000-06-15 2004-02-05 パーデュー・リサーチ・ファウンデーション ブタの先天性振せん用ワクチン
MY129765A (en) 2000-12-19 2007-04-30 Wyeth Corp Improved mycoplasma hyopneumoniae bacterin vaccine
US7018638B2 (en) 2000-12-19 2006-03-28 Wyeth Mycoplasma hyopneumoniae bacterin vaccine
JP2002247979A (ja) 2001-02-23 2002-09-03 Nippon Biologicals Inc マレック病ワクチンおよびその製造方法
PT1379671E (pt) 2001-03-27 2009-07-20 Univ Saskatchewan Métodos de cultura de circovírus
US20030096377A1 (en) 2001-06-28 2003-05-22 Virginia Tech Intellectual Properties, Inc. Differential PCR-RFLP assay for detecting and distinguishing between nonpathogenic PCV-1 and pathogenic PCV-2
DK2027873T3 (en) 2001-07-02 2015-11-09 Zoetis Services Llc Single Dose Vaccination with Mycoplasma hyopneumoniae
US7361352B2 (en) 2001-08-15 2008-04-22 Acambis, Inc. Influenza immunogen and vaccine
US7279166B2 (en) 2001-12-12 2007-10-09 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US7276353B2 (en) 2001-12-12 2007-10-02 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US6841364B2 (en) 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
WO2003068993A1 (en) 2002-02-14 2003-08-21 Novavax, Inc. Method for isolation and purification of expressed gene products in vitro
WO2003077860A2 (en) 2002-03-13 2003-09-25 Biophysica, Inc. BOSWELLIN COMPOSITIONS ENHANCED WITH 3-β-ACETYL-11-KETO-β-BOSWELLIC ACID (“AKBA”), INDUSTRIAL MANUFACTURE AND THEIR USES
US20030215455A1 (en) 2002-05-14 2003-11-20 Bailey Reynolds Vaccine stabilizer and method of use
AU2002951692A0 (en) 2002-09-23 2002-10-17 Vital Biotech (Hong Kong) Limited Improvements in or relating to vaccines
CA2514576C (en) 2003-02-03 2015-07-21 Cerebus Biologicals, Inc. Methods for treating, preventing and diagnosing helicobacter infection
US7563449B2 (en) 2003-04-21 2009-07-21 Pfizer Inc, Methods for reducing cattle reproductive diseases
CN1458167A (zh) 2003-06-02 2003-11-26 中国农业科学院哈尔滨兽医研究所 截短表达的猪圆环病毒ⅱ型衣壳蛋白抗原及其应用
US7335361B2 (en) 2003-06-09 2008-02-26 Animal Technology Institute Taiwan Fusion antigen used as vaccine
CA2533581C (en) 2003-07-24 2012-05-08 Merial Limited Vaccine formulations comprising an oil-in-water emulsion
CN1829529B (zh) 2003-07-25 2011-05-04 贝林格尔·英格海姆维特梅迪卡有限公司 源自欧洲的细胞内罗森氏菌及其疫苗,诊断剂及使用方法
FR2861731B1 (fr) 2003-10-30 2006-02-24 Centre Nat Rech Scient Nouvelle proteine de fixation du phosphate, compositions pharmaceutiques la contenant et ses utilisations
CN1942204A (zh) 2004-04-26 2007-04-04 株式会社中央疫苗研究所 用于猪呼吸病的灭活混合疫苗及其制备方法
CN1579553A (zh) 2004-05-18 2005-02-16 浙江大学 Ii型猪圆环病毒核酸疫苗的制备方法及其应用
CA2572389A1 (en) 2004-06-30 2006-06-29 Id Biomedical Corporation Of Quebec Vaccine compositions for treating coronavirus infection
US7700285B1 (en) 2005-12-29 2010-04-20 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
US7833707B2 (en) 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
RU2007130801A (ru) 2005-01-13 2009-02-20 Берингер Ингельхайм Ветмедика Гмбх (De) Улучшенные вакцины против репродуктивно-респираторного синдрома свиней (prrs)
US7300785B2 (en) 2005-02-03 2007-11-27 Universiteit Ghent Culturing circular ssDNA viruses for the production of vaccines
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
US7358075B2 (en) 2005-04-13 2008-04-15 Merial Limited Assay for porcine circovirus production
US7691368B2 (en) 2005-04-15 2010-04-06 Merial Limited Vaccine formulations
PL1926496T3 (pl) 2005-09-09 2014-02-28 Intervet Int Bv Szczepionka przeciw PCV-2
HUE025994T2 (en) 2005-12-29 2016-05-30 Boehringer Ingelheim Vetmedica Inc Use of PCV2 immunogenic composition to reduce clinical symptoms in piglets
EP1968630B1 (en) 2005-12-29 2018-01-24 Boehringer Ingelheim Vetmedica, Inc. Multivalent pcv2 immunogenic compositions
WO2008064299A2 (en) 2006-11-22 2008-05-29 Boehringer Ingelheim Vetmedica, Inc. Methods of reducing porcine circovirus-associated disease outbreaks
WO2008073464A2 (en) 2006-12-11 2008-06-19 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
HUE044410T2 (hu) * 2006-12-15 2019-10-28 Boehringer Ingelheim Animal Health Usa Inc Egydózisú anti-PCV2 sertés vakcina
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
US20090017064A1 (en) 2007-07-10 2009-01-15 Wyeth Methods and Compositions for Immunizing Pigs Against Porcine Circovirus
US7829274B2 (en) 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
ME01156B (me) 2007-12-21 2013-03-20 Zoetis Services Llc Postupci i kompozicije za imunizaciju svinja protiv svinjskog cirkovirusa
WO2009126356A2 (en) 2008-01-23 2009-10-15 Boehringer Ingelheim Vetmedica, Inc. Pcv2 mycoplasma hyopneumoniae immunogenic compositions and methods of producing such compositions
WO2009103037A1 (en) 2008-02-15 2009-08-20 Boehringer Ingelheim Vetmedica, Inc. Methods and compositions for reducing the impact of enteric diseases
US8444989B1 (en) 2008-04-18 2013-05-21 Boehringer Ingelheim Vetmedica Gmbh One dose vaccination against mycoplasma infections of pigs
AR078253A1 (es) 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
LT2547770T (lt) 2010-03-16 2020-05-11 Virginia Tech Intellectual Properties, Inc. Gyva susilpninta chimerinio kiaulių cirkoviruso vakcina
JP5719016B2 (ja) 2010-04-22 2015-05-13 コーニンクレッカ フィリップス エヌ ヴェ 皮膚接触ディテクタ
US9932372B2 (en) 2010-07-08 2018-04-03 United Biomedical, Inc. Designer peptide-based PCV2 vaccine
WO2012033911A2 (en) 2010-09-08 2012-03-15 The Johns Hopkins University Polyionic papilloma virus-like particle (vlp) vaccines
EP2564869A1 (en) 2011-09-02 2013-03-06 Ceva Sante Animale Synthetic capsid proteins and uses thereof
CN103122352B (zh) 2012-09-27 2015-02-11 华中农业大学 一种猪圆环病毒2型重组杆状病毒及制备方法和应用
EP2961766B1 (en) * 2013-03-01 2019-04-10 Boehringer Ingelheim Vetmedica, Inc. Quantification of vaccine compositions
WO2014179200A1 (en) 2013-04-30 2014-11-06 Boehringer Ingelheim Vetmedica, Inc. Orf2 protein of pcv2 subtype a (pcv2a) for use in cross-protection
MX373884B (es) * 2013-10-02 2020-03-26 Boehringer Ingelheim Animal Health Usa Inc Variante de la proteína pcv2 orf2 y partículas similares al virus compuestas por ésta.
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10555994B2 (en) * 2015-03-30 2020-02-11 Boehringer Ingelheim Animal Health USA Inc. PCV2 ORF2 carrier platform

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100184016A1 (en) * 2007-06-22 2010-07-22 David Jacques Gerard Lefebvre Methods and compositions in the treatment of porcine circoviral infection

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GenBank ACA49867, (2008.03.05.)
GenBank AEY79491, (2012)

Also Published As

Publication number Publication date
US20250243246A1 (en) 2025-07-31
EP3052516B1 (en) 2020-01-01
EA201600305A1 (ru) 2016-09-30
CN105658660A (zh) 2016-06-08
JP6778104B2 (ja) 2020-10-28
AU2014329524B2 (en) 2019-01-17
KR20220083861A (ko) 2022-06-20
DK3052516T3 (da) 2020-03-23
EA035265B1 (ru) 2020-05-21
US20150093404A1 (en) 2015-04-02
US11858963B2 (en) 2024-01-02
MX373884B (es) 2020-03-26
US20190023747A1 (en) 2019-01-24
US20210221852A1 (en) 2021-07-22
US9505808B2 (en) 2016-11-29
CA2924228C (en) 2024-01-16
JP2016534034A (ja) 2016-11-04
US10961281B2 (en) 2021-03-30
EP3052516A1 (en) 2016-08-10
KR20160058958A (ko) 2016-05-25
AU2014329524A1 (en) 2016-03-17
US20240076321A1 (en) 2024-03-07
US20170029471A1 (en) 2017-02-02
US12247051B2 (en) 2025-03-11
ES2778425T3 (es) 2020-08-10
US10131696B2 (en) 2018-11-20
MX2016004063A (es) 2016-06-06
WO2015051099A1 (en) 2015-04-09
CA2924228A1 (en) 2015-04-09

Similar Documents

Publication Publication Date Title
US12247051B2 (en) PCV2 ORF2 protein variant and virus like particles composed thereof
EP2114447B1 (en) Prevention and treatment of sub-clinical pcvd
EP3035958B1 (en) Porcine circovirus type 2 (pcv2) subunit vaccine
US20200237894A1 (en) Pcv2 orf2 carrier platform
US12433942B2 (en) Porcine circovirus type 3 (PCV3) vaccines, and production and uses thereof

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20160502

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
AMND Amendment
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20191001

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20210208

Patent event code: PE09021S01D

AMND Amendment
E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20211222

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20210208

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

AMND Amendment
PX0901 Re-examination

Patent event code: PX09011S01I

Patent event date: 20211222

Comment text: Decision to Refuse Application

Patent event code: PX09012R01I

Patent event date: 20210809

Comment text: Amendment to Specification, etc.

Patent event code: PX09012R01I

Patent event date: 20191001

Comment text: Amendment to Specification, etc.

PX0701 Decision of registration after re-examination

Patent event date: 20220308

Comment text: Decision to Grant Registration

Patent event code: PX07013S01D

Patent event date: 20220217

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

Patent event date: 20211222

Comment text: Decision to Refuse Application

Patent event code: PX07011S01I

Patent event date: 20210809

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

Patent event date: 20191001

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

X701 Decision to grant (after re-examination)
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20220610

PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20220610

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20220613

End annual number: 3

Start annual number: 1

PG1601 Publication of registration