KR20210128511A - 우롤리틴 또는 이의 전구체를 투여에 의한 자가포식 향상 또는 장수 증가 - Google Patents

우롤리틴 또는 이의 전구체를 투여에 의한 자가포식 향상 또는 장수 증가 Download PDF

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KR20210128511A
KR20210128511A KR1020217033621A KR20217033621A KR20210128511A KR 20210128511 A KR20210128511 A KR 20210128511A KR 1020217033621 A KR1020217033621 A KR 1020217033621A KR 20217033621 A KR20217033621 A KR 20217033621A KR 20210128511 A KR20210128511 A KR 20210128511A
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urolithin
cells
cell
certain embodiments
relates
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윌리엄 블랑코-보세
베르나드 슈나이더
로렌트 모우치로드
동렬 류
페넬로페 안드렉스
조한 오웨릭스
크리스토퍼 엘. 린쉬
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아마젠티스 에스에이
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Priority to KR1020237025456A priority Critical patent/KR20230116091A/ko
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KR1020217033621A 2012-06-27 2013-06-27 우롤리틴 또는 이의 전구체를 투여에 의한 자가포식 향상 또는 장수 증가 Ceased KR20210128511A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237025456A KR20230116091A (ko) 2012-06-27 2013-06-27 우롤리틴 또는 이의 전구체를 투여에 의한 자가포식향상 또는 장수 증가

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201261665137P 2012-06-27 2012-06-27
US61/665,137 2012-06-27
US201261712886P 2012-10-12 2012-10-12
US61/712,886 2012-10-12
US201361791137P 2013-03-15 2013-03-15
US61/791,137 2013-03-15
KR1020207027814A KR102317160B1 (ko) 2012-06-27 2013-06-27 우롤리틴 또는 이의 전구체를 투여에 의한 자가포식 향상 또는 장수 증가
PCT/US2013/048310 WO2014004902A2 (en) 2012-06-27 2013-06-27 Enhancing autophagy or increasing longevity by administration of urolithins or precursors thereof

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Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201610798QA (en) * 2012-06-27 2017-02-27 Amazentis Sa Enhancing autophagy or increasing longevity by administration of urolithins or precursors thereof
US20160045472A1 (en) * 2013-01-18 2016-02-18 Procell Sprl Urolithin b for muscle growth
AU2014317857B2 (en) * 2013-09-09 2020-01-02 Natreon, Inc. Regulation of body weight gain by using dibenzo-alpha-pyrones
EP2862568A1 (en) 2013-10-15 2015-04-22 Centre National de la Recherche Scientifique (CNRS) Compositions comprising urolithins and uses thereof for the stimulation of insulin secretion
CA2972013C (en) 2013-12-23 2020-04-28 Amazentis Sa Process-scale synthesis of urolithins
GB201323008D0 (en) 2013-12-24 2014-02-12 Amazentis As Compounds and uses thereof
GB201413228D0 (en) 2014-07-25 2014-09-10 Nugerontix Ltd Polyphenol compositions
WO2016099947A1 (en) * 2014-12-19 2016-06-23 Halo Life Science, Llc Use of ellagic acid dihydrate in food products and nutraceuticals
EP3284734B1 (en) * 2015-04-13 2021-12-01 Sumitomo Seika Chemicals Co., Ltd. Method for producing 2-halogenated benzoic acids
JP6740548B2 (ja) * 2015-05-15 2020-08-19 公立大学法人岡山県立大学 ウロリチン類を含有する育毛剤、及び、ウロリチン類を含有する5αレダクターゼ活性阻害剤
JP2017014154A (ja) * 2015-07-01 2017-01-19 公立大学法人岡山県立大学 ウロリチン類を含有するヒアルロン酸産生促進剤
JP6799767B2 (ja) * 2015-07-07 2020-12-16 公立大学法人岡山県立大学 ウロリチン類を含有するメラニン産生抑制剤
GB201515391D0 (en) 2015-08-28 2015-10-14 Amazentis Sa Compositions
JP7182837B2 (ja) * 2015-12-24 2022-12-05 アマゼンティス エスアー ニコチンアミドリボシド及びウロリチンを含む組成物
JP2017210444A (ja) * 2016-05-26 2017-11-30 株式会社ダイセル ウロリチン類を含有するリパーゼ阻害剤
JP6791478B2 (ja) * 2016-05-26 2020-11-25 株式会社ダイセル ウロリチン類を含有するアンジオテンシン変換酵素阻害剤
ES2985944T3 (es) * 2016-06-29 2024-11-07 Halo Life Science Llc Método de preparación de una sal de ellagato de dicolinio de poco olor y otras sales orgánicas de colina de poco olor
US10774328B2 (en) 2016-07-11 2020-09-15 University Of North Texas Health Science Center At Fort Worth Treatment for glaucoma and other eye diseases
WO2018085419A1 (en) 2016-11-01 2018-05-11 Jian Feng Method of producing naive pluripotent stem cells
EP3354645A1 (en) 2017-01-26 2018-08-01 Patheon Austria GmbH & Co KG Process for preparing urolithins
EP3592425A1 (en) * 2017-03-08 2020-01-15 Amazentis SA Methods for improving mitophagy in subjects
EP3592424A1 (en) * 2017-03-08 2020-01-15 Amazentis SA Methods for improving mitophagy in subjects
JP2020510036A (ja) 2017-03-08 2020-04-02 アマゼンティス エスアーAmazentis Sa 皮膚の処置方法
JP2019097566A (ja) * 2017-12-07 2019-06-24 大正製薬株式会社 体内時計調整用組成物
EP3727419A1 (en) * 2017-12-20 2020-10-28 Société des Produits Nestlé S.A. Compositions and methods using a combination of autophagy inducer and high protein for induction of autophagy
BR112020009132A2 (pt) * 2017-12-20 2020-10-20 Société des Produits Nestlé S.A. composições e métodos que usam alta proteína para indução de autofagia
CA3089695A1 (en) * 2018-02-19 2019-08-22 Natreon, Inc. Synergistic combinations of urolithins a and b for improving cognitive capacity or cognitive function
WO2019163437A1 (ja) 2018-02-21 2019-08-29 株式会社ダイセル ウロリチン類を含有する破骨細胞分化抑制剤
IL276886B2 (en) * 2018-02-27 2024-11-01 Amazentis Sa Urolitin A synthesis process
JP7217542B2 (ja) * 2018-03-29 2023-02-03 国立大学法人 琉球大学 分化コントロール化合物を用いて造腫瘍性をもつおそれのある未分化iPS細胞等の混入を除去する方法
US10792276B2 (en) * 2018-04-30 2020-10-06 Amazentis Sa Urolithins as immune response enhancers
AU2019269401A1 (en) * 2018-05-15 2021-01-07 The Institute For Stem Cell Biology And Regenerative Medicine (Instem) Urolithin A and derivatives thereof for use in therapy
EP3801587A4 (en) * 2018-06-05 2022-08-10 Flagship Pioneering Innovations V, Inc. ACYLATED CATECHIN POLYPHENOLS AND METHODS OF USE THEREOF FOR THE TREATMENT OF CANCER
MX2020013104A (es) 2018-06-05 2021-05-12 Flagship Pioneering Innovations V Inc Agentes activos y metodos de uso para el tratamiento de trastornos metabolicos y enfermedad hepatica no alcoholica.
CN108676013B (zh) * 2018-06-25 2021-01-01 中国医学科学院医药生物技术研究所 具有自噬激活活性的黄醇酮类化合物、其制备方法及其制药应用
CN109316478A (zh) * 2018-11-06 2019-02-12 上海出入境检验检疫局动植物与食品检验检疫技术中心 一种尿石素a在制备抗衰老的药物、化妆品中的应用及药物、化妆品
PL245399B1 (pl) 2018-11-29 2024-07-15 Univ Warszawski Medyczny Kompozycja farmaceutyczna zawierająca urolitynę A lub jej pochodną do zastosowania zewnętrznego miejscowego w leczeniu, hamowaniu i zapobieganiu chorobom skóry i błon śluzowych o podłożu zapalnym
EP3911312A1 (en) * 2019-01-18 2021-11-24 Société des Produits Nestlé S.A. Agents and methods for increasing stem cell function
CN110066284B (zh) * 2019-02-01 2021-06-04 贵阳倍隆生物科技有限公司 一种一锅法合成鞣花酸的方法
CN110229167B (zh) * 2019-05-22 2020-11-24 珠海萱嘉君行健康产业发展有限公司 一种利用五倍子制备鞣花酸的方法、制得的鞣花酸及其应用
CN111995610A (zh) * 2019-05-27 2020-11-27 首都医科大学 一种尿石素类化合物用于治疗胶质母细胞瘤药物的应用
WO2020257283A1 (en) * 2019-06-18 2020-12-24 Mitopower Llc Nicotinyl riboside compounds and their uses
US20220184015A1 (en) * 2019-06-20 2022-06-16 Societe Des Produits Nestle S.A. Compositions and methods to potentiate musculoskeletal effect of one or more anabolic amino acids on bone health
GB201912107D0 (en) * 2019-08-22 2019-10-09 Amazentis Sa Combination
GB201915191D0 (en) * 2019-10-21 2019-12-04 Floratek Gmbh Novel heterocyclic compounds
GB201916046D0 (en) 2019-11-04 2019-12-18 Amazentis Sa Diagnostic method
CN114760996A (zh) * 2019-11-27 2022-07-15 雀巢产品有限公司 与间接ampk活化剂化合物组合的直接ampk活化剂化合物、组合物、方法和其用途
WO2021105073A1 (en) * 2019-11-27 2021-06-03 Société des Produits Nestlé S.A. Benzocoumarin ampk activator compounds, compositions, methods and uses thereof
CN113018305A (zh) * 2019-12-24 2021-06-25 兰州大学 一种化合物在制备治疗阿尔兹海默症药物中的应用
CA3168493A1 (en) * 2020-02-20 2021-08-26 The Royal Institution For The Advancement Of Learning/Mcgill University Use of castalagin or analogs thereof for anti-cancer efficacy and to increase the response to immune checkpoint inhibitors
US20240000753A1 (en) * 2020-07-17 2024-01-04 The Trustees Of Columbia University In The City Of New York Methods and compositions to increase lifespan and healthspan by mimicking the effects of time-restricted feeding
CN111983058B (zh) * 2020-07-30 2023-06-23 云南中医药大学 中药抗非酒精性脂肪肝活性物质的筛选方法
WO2022051643A1 (en) * 2020-09-04 2022-03-10 Natreon, Inc. Methods of treating and preventing hepatotoxicity
US20230372291A1 (en) 2020-09-25 2023-11-23 Societe Des Produits Nestle S.A. Compositions and methods using xanthan gum to stabilize at least one urolithin in an aqueous matrix
KR102623664B1 (ko) 2020-12-10 2024-01-12 서울대학교산학협력단 유로리틴 a를 이용한 당뇨성 알츠하이머병의 치료 조성물 및 치료 방법
US11820751B2 (en) 2021-01-27 2023-11-21 Vandria Sa Urolithin derivatives and methods of use thereof
CN112716938A (zh) * 2021-02-25 2021-04-30 新疆医科大学 鞣花酸在制备缓解眼组织病变的药物中的用途
KR102677423B1 (ko) * 2021-09-17 2024-06-21 조선대학교산학협력단 망기페린을 포함하는 자가포식 활성화용 조성물
KR102690860B1 (ko) * 2021-10-13 2024-08-05 한국해양과학기술원 남극 진균 균주 Pleosporales sp. SF-7343 유래 대사화합물을 포함하는 염증질환 예방 또는 치료용 조성물
MX2024004180A (es) * 2021-10-28 2024-04-23 Nestle Sa Composiciones y metodos que usan una combinacion de nutrientes para favorecer la cognicion y la salud emocional en un mamifero.
EP4482947A1 (en) 2022-02-24 2025-01-01 Amazentis SA Uses of urolithins
KR20250044178A (ko) 2022-03-22 2025-03-31 아마젠티스 에스에이 조성물
EP4536212A2 (en) * 2022-06-06 2025-04-16 Amazentis SA Urolithins for improving cardiac function and health
JP2025527175A (ja) * 2022-07-27 2025-08-20 ヴァンドリア エスアー ウロリチン誘導体の治療的使用
CN115433151A (zh) * 2022-09-02 2022-12-06 苏州大学 一种6,7,8-三羟基香豆素的制备方法
CN115581689B (zh) * 2022-10-17 2024-05-14 常州大学 尿石素b酰胺类衍生物的应用
GB202219317D0 (en) 2022-12-20 2023-02-01 Amazentis Sa Methods for improving mitophagy in subjects
GB202308224D0 (en) 2023-06-01 2023-07-19 Amazentis Sa Formulation
CN116966188A (zh) * 2023-07-14 2023-10-31 天津医科大学总医院 丁香素在制备治疗和/或预防炎症性肠病药物中的应用
GB202312220D0 (en) 2023-08-09 2023-09-20 Amazentis Sa Formulation
WO2025076497A1 (en) * 2023-10-06 2025-04-10 Northeast Ohio Medical University Combination treatment of tau pathology
FR3153996A1 (fr) * 2023-10-13 2025-04-18 L'oreal Utilisation cosmétique d'au moins l’urolithine C sur une peau sensible
FR3153997A1 (fr) * 2023-10-13 2025-04-18 L'oreal Utilisation cosmétique d'au moins l’urolithine B sur une peau sensible
WO2025078645A1 (en) * 2023-10-13 2025-04-17 L'oreal Cosmetic use of at least urolithin b or c on a sensitive skin
FR3153998A1 (fr) * 2023-10-13 2025-04-18 L'oreal Utilisation cosmétique d’iso-urolithine A sur une peau sensible
GB202316295D0 (en) 2023-10-24 2023-12-06 Amazentis Sa Composition
GB202319994D0 (en) 2023-12-22 2024-02-07 Amazentis Sa Compositions for use
CN117771237B (zh) * 2024-02-27 2024-05-03 南昌医学院 一种松香烷型二萜化合物的用途和制备方法
WO2025194036A1 (en) * 2024-03-14 2025-09-18 Washington University Autophagy enhancers
WO2025224366A1 (en) 2024-04-26 2025-10-30 Amazentis Sa Immune health improvers
WO2025252771A1 (en) 2024-06-03 2025-12-11 Amazentis Sa Urolithin combinations
CN119792272B (zh) * 2025-02-07 2025-10-03 陕西中鸿科瑞再生医学研究院有限公司 一种改善睡眠的组合物及其制备方法与制剂

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6479103A (en) 1987-06-09 1989-03-24 Lion Corp External preparation
DE69923322T2 (de) 1998-07-30 2005-12-22 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Verwendung von propionyl-l-carnitin und acetyl-l-carnitin zur herstellung von arzneimittel mit antikrebs wirkung
US6440436B1 (en) 2001-05-18 2002-08-27 Natreon Inc. Process for preparing purified shilajit composition from native shilajit
US20050171079A1 (en) 2004-02-04 2005-08-04 Schrimpf Michael R. Amino-substituted tricyclic derivatives and methods of use
US7365193B2 (en) 2004-02-04 2008-04-29 Abbott Laboratories Amino-substituted tricyclic derivatives and methods of use
US20050282781A1 (en) 2004-06-18 2005-12-22 Shibnath Ghosal Compositions of stable bioactive metabolites of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids
US8475776B2 (en) 2005-04-28 2013-07-02 Paloma Pharmaceuticals, Inc. Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis
US20060257337A1 (en) 2005-04-28 2006-11-16 David Sherris Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis
US8183282B2 (en) * 2006-04-26 2012-05-22 The Regents Of The University Of California Therapeutic uses of urolithins
US8894993B2 (en) * 2006-08-04 2014-11-25 Natreon Inc. Mitochondria-targeted antioxidants
EP2155154A2 (fr) * 2007-05-11 2010-02-24 Galderma Research & Development Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations
WO2008139124A2 (fr) * 2007-05-11 2008-11-20 Galderma Research & Development Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations
TW200929211A (en) 2007-12-17 2009-07-01 Etron Technology Inc Method of reducing current of memory in self-refreshing mode
JP2011507910A (ja) * 2007-12-21 2011-03-10 ユニバーシティー オブ ロチェスター 真核生物の寿命を変更するための方法
US20110021618A1 (en) 2008-03-25 2011-01-27 Paloma Pharmaceuticals, Inc. Methods of treating fibrotic disorders
CN102612564B (zh) * 2009-04-10 2015-08-26 齐海燕 新的抗衰老试剂及其鉴别方法
JP5385686B2 (ja) 2009-06-05 2014-01-08 サントリーホールディングス株式会社 血小板凝集抑制剤
US8933217B2 (en) * 2009-07-24 2015-01-13 Amazentis Sa Compounds, compositions, and methods for protecting brain health in neurodegenerative disorders
DK3372228T3 (da) * 2010-12-23 2025-05-26 Amazentis Sa Ikke-terapeutisk fremgangsmåde til at øge eller opretholde mitokondriefunktion
WO2012113835A1 (en) 2011-02-22 2012-08-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) C-glucosidic ellagitannin compounds for use for altering the supramolecular arrangement of actin and for the treatment of osteoporosis, cancer, bacterial infection and viral infection
SG10201610798QA (en) 2012-06-27 2017-02-27 Amazentis Sa Enhancing autophagy or increasing longevity by administration of urolithins or precursors thereof
JP7182837B2 (ja) 2015-12-24 2022-12-05 アマゼンティス エスアー ニコチンアミドリボシド及びウロリチンを含む組成物

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