KR20210039987A - 티피파닙의 합성 - Google Patents
티피파닙의 합성 Download PDFInfo
- Publication number
- KR20210039987A KR20210039987A KR1020207036324A KR20207036324A KR20210039987A KR 20210039987 A KR20210039987 A KR 20210039987A KR 1020207036324 A KR1020207036324 A KR 1020207036324A KR 20207036324 A KR20207036324 A KR 20207036324A KR 20210039987 A KR20210039987 A KR 20210039987A
- Authority
- KR
- South Korea
- Prior art keywords
- tipipanib
- mixture
- racemic
- acid
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862673693P | 2018-05-18 | 2018-05-18 | |
| US62/673,693 | 2018-05-18 | ||
| PCT/US2019/032765 WO2019222565A1 (en) | 2018-05-18 | 2019-05-17 | Synthesis of tipifarnib |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20210039987A true KR20210039987A (ko) | 2021-04-12 |
Family
ID=66770583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207036324A Withdrawn KR20210039987A (ko) | 2018-05-18 | 2019-05-17 | 티피파닙의 합성 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11542244B2 (https=) |
| EP (1) | EP3793966A1 (https=) |
| JP (1) | JP2021526513A (https=) |
| KR (1) | KR20210039987A (https=) |
| CN (1) | CN112424149B (https=) |
| AU (1) | AU2019270163A1 (https=) |
| BR (1) | BR112020023559A2 (https=) |
| CA (1) | CA3100706A1 (https=) |
| EA (1) | EA202092787A1 (https=) |
| MX (1) | MX2020012305A (https=) |
| PH (1) | PH12020551956A1 (https=) |
| SG (1) | SG11202011378WA (https=) |
| WO (1) | WO2019222565A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240136572A (ko) | 2023-03-07 | 2024-09-19 | 단국대학교 천안캠퍼스 산학협력단 | 티피파르닙을 유효성분으로 포함하는 근감소증 예방 또는 치료용 약학 조성물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE214695T1 (de) | 1994-09-23 | 2002-04-15 | Darwin Discovery Ltd | Racemisierungsverfahren bei der herstellung von levobupivacaine und analogen |
| AU702594B2 (en) * | 1995-10-13 | 1999-02-25 | Duphar International Research B.V. | Process for the preparation of enantiomerically pure imidazolyl compounds |
| DE69620445T2 (de) | 1995-12-08 | 2002-12-12 | Janssen Pharmaceutica N.V., Beerse | (imidazol-5-yl)methyl-2-chinolinoderivate als farnesyl protein transferase inhibitoren |
| BRPI0208075B8 (pt) * | 2001-03-12 | 2021-05-25 | Janssen Pharmaceutica Nv | processo para a preparação de compostos de imidazol |
| DE602005007604D1 (de) * | 2004-05-03 | 2008-07-31 | Janssen Pharmaceutica Nv | Diastereoselektive addition von lithiiertem n-methylimidazol an sulfinimine |
| JP5008554B2 (ja) * | 2004-05-03 | 2012-08-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | イミダゾール化合物の製造用のジアステレオ選択的合成方法 |
| CN100567291C (zh) * | 2004-05-03 | 2009-12-09 | 詹森药业有限公司 | 用6-溴-4-(3-氯苯基)-2-甲氧基喹啉进行的非对映选择性合成方法 |
| EP3221311B1 (en) * | 2014-11-21 | 2019-10-30 | Merck Patent GmbH | Method for the production of praziquantel |
| CN104876856B (zh) | 2015-05-05 | 2017-11-21 | 河北凯力昂生物科技有限公司 | 一种拆分法制备(r)‑(+)‑3‑氨基哌啶二盐酸盐的方法 |
-
2019
- 2019-05-17 CA CA3100706A patent/CA3100706A1/en active Pending
- 2019-05-17 EA EA202092787A patent/EA202092787A1/ru unknown
- 2019-05-17 KR KR1020207036324A patent/KR20210039987A/ko not_active Withdrawn
- 2019-05-17 CN CN201980047803.3A patent/CN112424149B/zh active Active
- 2019-05-17 AU AU2019270163A patent/AU2019270163A1/en not_active Abandoned
- 2019-05-17 JP JP2020564572A patent/JP2021526513A/ja not_active Withdrawn
- 2019-05-17 EP EP19728818.6A patent/EP3793966A1/en not_active Withdrawn
- 2019-05-17 WO PCT/US2019/032765 patent/WO2019222565A1/en not_active Ceased
- 2019-05-17 MX MX2020012305A patent/MX2020012305A/es unknown
- 2019-05-17 US US17/056,745 patent/US11542244B2/en active Active
- 2019-05-17 SG SG11202011378WA patent/SG11202011378WA/en unknown
- 2019-05-17 BR BR112020023559-8A patent/BR112020023559A2/pt not_active Application Discontinuation
-
2020
- 2020-11-16 PH PH12020551956A patent/PH12020551956A1/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240136572A (ko) | 2023-03-07 | 2024-09-19 | 단국대학교 천안캠퍼스 산학협력단 | 티피파르닙을 유효성분으로 포함하는 근감소증 예방 또는 치료용 약학 조성물 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021526513A (ja) | 2021-10-07 |
| PH12020551956A1 (en) | 2021-08-16 |
| CA3100706A1 (en) | 2019-11-21 |
| US20210246114A1 (en) | 2021-08-12 |
| EA202092787A1 (ru) | 2021-02-09 |
| MX2020012305A (es) | 2021-03-25 |
| AU2019270163A1 (en) | 2020-12-03 |
| CN112424149A (zh) | 2021-02-26 |
| CN112424149B (zh) | 2023-06-23 |
| EP3793966A1 (en) | 2021-03-24 |
| SG11202011378WA (en) | 2020-12-30 |
| US11542244B2 (en) | 2023-01-03 |
| WO2019222565A1 (en) | 2019-11-21 |
| BR112020023559A2 (pt) | 2021-02-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| PC1202 | Submission of document of withdrawal before decision of registration |
St.27 status event code: N-1-6-B10-B11-nap-PC1202 |
|
| WITB | Written withdrawal of application | ||
| R18 | Changes to party contact information recorded |
Free format text: ST27 STATUS EVENT CODE: A-3-3-R10-R18-OTH-X000 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |