EA202092787A1 - Синтез типифарниба - Google Patents

Синтез типифарниба

Info

Publication number
EA202092787A1
EA202092787A1 EA202092787A EA202092787A EA202092787A1 EA 202092787 A1 EA202092787 A1 EA 202092787A1 EA 202092787 A EA202092787 A EA 202092787A EA 202092787 A EA202092787 A EA 202092787A EA 202092787 A1 EA202092787 A1 EA 202092787A1
Authority
EA
Eurasian Patent Office
Prior art keywords
typifarnibus
synthesis
methyl
chlorophenyl
tipifarnib
Prior art date
Application number
EA202092787A
Other languages
English (en)
Inventor
Пинда Жэнь
Сяоху Дэн
Ваньпин Май
Original Assignee
Кура Онколоджи, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кура Онколоджи, Инк. filed Critical Кура Онколоджи, Инк.
Publication of EA202092787A1 publication Critical patent/EA202092787A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

В настоящем изобретении предлагаются способы получения желаемого энантиомера 6-[амино(4-хлорфенил)(1-метил-1H-имидазол-5-ил)метил]-4-(3-хлорфенил)-1-метил-2(1H)-хинолинона, известного еще как типифарниб.
EA202092787A 2018-05-18 2019-05-17 Синтез типифарниба EA202092787A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862673693P 2018-05-18 2018-05-18
PCT/US2019/032765 WO2019222565A1 (en) 2018-05-18 2019-05-17 Synthesis of tipifarnib

Publications (1)

Publication Number Publication Date
EA202092787A1 true EA202092787A1 (ru) 2021-02-09

Family

ID=66770583

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202092787A EA202092787A1 (ru) 2018-05-18 2019-05-17 Синтез типифарниба

Country Status (13)

Country Link
US (1) US11542244B2 (ru)
EP (1) EP3793966A1 (ru)
JP (1) JP2021526513A (ru)
KR (1) KR20210039987A (ru)
CN (1) CN112424149B (ru)
AU (1) AU2019270163A1 (ru)
BR (1) BR112020023559A2 (ru)
CA (1) CA3100706A1 (ru)
EA (1) EA202092787A1 (ru)
MX (1) MX2020012305A (ru)
PH (1) PH12020551956A1 (ru)
SG (1) SG11202011378WA (ru)
WO (1) WO2019222565A1 (ru)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU695479B2 (en) * 1994-09-23 1998-08-13 Darwin Discovery Limited Racemisation and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
IL123568A (en) 1995-12-08 2001-08-08 Janssen Pharmaceutica Nv History (Imidazole - 5Il) Methyl-2-quinolinone inhibitors of Prenzyl transferase, their preparation, pharmaceutical preparations containing them and their preparation and drugs containing them
ES2236505T3 (es) * 2001-03-12 2005-07-16 Janssen Pharmaceutica N.V. Procedimiento para la preparacin de compuestos de imidazol.
EP1756085B1 (en) * 2004-05-03 2010-06-16 Janssen Pharmaceutica N.V. Diastereoselective synthesis process with 6-bromo-4-(3-chlorophenyl)-2-methoxy-quinoline
CN100567290C (zh) * 2004-05-03 2009-12-09 詹森药业有限公司 锂化n-甲基咪唑在亚磺基亚胺上的非对映选择性加成
ES2308486T3 (es) * 2004-05-03 2008-12-01 Janssen Pharmaceutica Nv Proceso de sintesis diastereoselectiva para la preparacion de compuestos de imidazol.
CN107108607B (zh) * 2014-11-21 2020-11-06 默克专利股份有限公司 制备吡喹酮的方法
CN104876856B (zh) 2015-05-05 2017-11-21 河北凯力昂生物科技有限公司 一种拆分法制备(r)‑(+)‑3‑氨基哌啶二盐酸盐的方法

Also Published As

Publication number Publication date
US11542244B2 (en) 2023-01-03
PH12020551956A1 (en) 2021-08-16
JP2021526513A (ja) 2021-10-07
CN112424149B (zh) 2023-06-23
MX2020012305A (es) 2021-03-25
WO2019222565A1 (en) 2019-11-21
EP3793966A1 (en) 2021-03-24
CN112424149A (zh) 2021-02-26
CA3100706A1 (en) 2019-11-21
SG11202011378WA (en) 2020-12-30
KR20210039987A (ko) 2021-04-12
US20210246114A1 (en) 2021-08-12
AU2019270163A1 (en) 2020-12-03
BR112020023559A2 (pt) 2021-02-09

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