CN112424149B - 替吡法尼的合成 - Google Patents

替吡法尼的合成 Download PDF

Info

Publication number
CN112424149B
CN112424149B CN201980047803.3A CN201980047803A CN112424149B CN 112424149 B CN112424149 B CN 112424149B CN 201980047803 A CN201980047803 A CN 201980047803A CN 112424149 B CN112424149 B CN 112424149B
Authority
CN
China
Prior art keywords
tipifarnib
mixture
racemic
iii
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201980047803.3A
Other languages
English (en)
Chinese (zh)
Other versions
CN112424149A (zh
Inventor
任平达
邓小虎
麦万平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kura Oncology Inc
Original Assignee
Kura Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kura Oncology Inc filed Critical Kura Oncology Inc
Publication of CN112424149A publication Critical patent/CN112424149A/zh
Application granted granted Critical
Publication of CN112424149B publication Critical patent/CN112424149B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201980047803.3A 2018-05-18 2019-05-17 替吡法尼的合成 Active CN112424149B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862673693P 2018-05-18 2018-05-18
US62/673,693 2018-05-18
PCT/US2019/032765 WO2019222565A1 (en) 2018-05-18 2019-05-17 Synthesis of tipifarnib

Publications (2)

Publication Number Publication Date
CN112424149A CN112424149A (zh) 2021-02-26
CN112424149B true CN112424149B (zh) 2023-06-23

Family

ID=66770583

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980047803.3A Active CN112424149B (zh) 2018-05-18 2019-05-17 替吡法尼的合成

Country Status (13)

Country Link
US (1) US11542244B2 (https=)
EP (1) EP3793966A1 (https=)
JP (1) JP2021526513A (https=)
KR (1) KR20210039987A (https=)
CN (1) CN112424149B (https=)
AU (1) AU2019270163A1 (https=)
BR (1) BR112020023559A2 (https=)
CA (1) CA3100706A1 (https=)
EA (1) EA202092787A1 (https=)
MX (1) MX2020012305A (https=)
PH (1) PH12020551956A1 (https=)
SG (1) SG11202011378WA (https=)
WO (1) WO2019222565A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102839264B1 (ko) 2023-03-07 2025-07-29 단국대학교 천안캠퍼스 산학협력단 티피파르닙을 유효성분으로 포함하는 근감소증 예방 또는 치료용 약학 조성물

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1159184A (zh) * 1994-09-23 1997-09-10 奇罗斯恩有限公司 制左旋布比卡因及类似物中所用的外消旋及不对称转变方法
CN1160053A (zh) * 1995-10-13 1997-09-24 杜菲尔国际开发有限公司 制备对映体纯的咪唑基化合物的方法
CN1496363A (zh) * 2001-03-12 2004-05-12 ղɭҩҵ���޹�˾ 咪唑化合物的制备方法
CN1946711A (zh) * 2004-05-03 2007-04-11 詹森药业有限公司 制备咪唑化合物的非对映选择性合成方法
CN1946710A (zh) * 2004-05-03 2007-04-11 詹森药业有限公司 用6－溴－4－(3－氯苯基)－2－甲氧基喹啉进行的非对映选择性合成方法
CN1946709A (zh) * 2004-05-03 2007-04-11 詹森药业有限公司 锂化n－甲基咪唑在亚磺基亚胺上的非对映选择性加成
CN107108607A (zh) * 2014-11-21 2017-08-29 默克专利股份有限公司 制备吡喹酮的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69620445T2 (de) 1995-12-08 2002-12-12 Janssen Pharmaceutica N.V., Beerse (imidazol-5-yl)methyl-2-chinolinoderivate als farnesyl protein transferase inhibitoren
CN104876856B (zh) 2015-05-05 2017-11-21 河北凯力昂生物科技有限公司 一种拆分法制备(r)‑(+)‑3‑氨基哌啶二盐酸盐的方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1159184A (zh) * 1994-09-23 1997-09-10 奇罗斯恩有限公司 制左旋布比卡因及类似物中所用的外消旋及不对称转变方法
CN1160053A (zh) * 1995-10-13 1997-09-24 杜菲尔国际开发有限公司 制备对映体纯的咪唑基化合物的方法
CN1496363A (zh) * 2001-03-12 2004-05-12 ղɭҩҵ���޹�˾ 咪唑化合物的制备方法
CN1946711A (zh) * 2004-05-03 2007-04-11 詹森药业有限公司 制备咪唑化合物的非对映选择性合成方法
CN1946710A (zh) * 2004-05-03 2007-04-11 詹森药业有限公司 用6－溴－4－(3－氯苯基)－2－甲氧基喹啉进行的非对映选择性合成方法
CN1946709A (zh) * 2004-05-03 2007-04-11 詹森药业有限公司 锂化n－甲基咪唑在亚磺基亚胺上的非对映选择性加成
CN107108607A (zh) * 2014-11-21 2017-08-29 默克专利股份有限公司 制备吡喹酮的方法

Also Published As

Publication number Publication date
JP2021526513A (ja) 2021-10-07
PH12020551956A1 (en) 2021-08-16
CA3100706A1 (en) 2019-11-21
US20210246114A1 (en) 2021-08-12
EA202092787A1 (ru) 2021-02-09
MX2020012305A (es) 2021-03-25
KR20210039987A (ko) 2021-04-12
AU2019270163A1 (en) 2020-12-03
CN112424149A (zh) 2021-02-26
EP3793966A1 (en) 2021-03-24
SG11202011378WA (en) 2020-12-30
US11542244B2 (en) 2023-01-03
WO2019222565A1 (en) 2019-11-21
BR112020023559A2 (pt) 2021-02-09

Similar Documents

Publication Publication Date Title
CA2707790C (en) Processes for the preparation of sitagliptin and pharmaceutically acceptable salts thereof
EP3174855B1 (en) Coformer salts of (2s,3s)-methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1h-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate and methods of preparing them
CN103539795A (zh) 阿哌沙班的多晶型及其制备方法
ES2575000T3 (es) Proceso mejorado para la preparación de ambrisentano
CN104418841B (zh) 一种光学纯雷贝拉唑及其钠盐的制备方法
WO2014157612A1 (ja) （１ｓ，４ｓ，５ｓ）－４－ブロモ－６－オキサビシクロ［３．２．１］オクタン－７－オンの製造方法
WO2016107289A1 (zh) 制备索非布韦晶型6的方法
JP5654462B2 (ja) 貧溶媒添加法による２−（３−シアノ−４−イソブチルオキシフェニル）−４−メチル−５−チアゾールカルボン酸の結晶多形体の製造方法
CN102924434B (zh) 一种右旋雷贝拉唑钠单水合物晶型及其制备方法
CN112424149B (zh) 替吡法尼的合成
CN105085486A (zh) 一种右旋雷贝拉唑钠的精制方法
US20100081839A1 (en) Process for preparation of crystalline clopidogrel hydrogen sulphate form i
CN103497145B (zh) 一种光学纯多奈哌齐的制备工艺
WO2019052470A1 (zh) 一种艾尔骨化醇晶型、药物组合物及制备方法和应用
EA042764B1 (ru) Способы получения (r)-(+)-типифарниба
KR20220164767A (ko) 4,5-디하이드로-1h-피라졸 및 중간체의 제조 방법
EP2610239A1 (en) Preparation Of Rasagiline Hemitartrate
CN110885315A (zh) 左西孟旦药重要中间体的制备方法
AU2019394523B2 (en) Crystalline form of propanamide derivative and preparation method therefor
WO2024140870A1 (zh) 一种拆分雷米普利中间体的方法
CN107674072B (zh) 二氢嘧啶衍生物及其酸加成物的制备方法
CN103382175B (zh) 一种丁酸氯维地平晶型ⅱ的制备方法
WO2011103762A1 (zh) 拉米夫定草酸盐及其制备方法
HK1236192B (zh) 一种共形成体盐及其制备方法
WO2017168333A1 (en) Amifampridine dihydrochloride

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant