EA202092787A1 - Синтез типифарниба - Google Patents
Синтез типифарнибаInfo
- Publication number
- EA202092787A1 EA202092787A1 EA202092787A EA202092787A EA202092787A1 EA 202092787 A1 EA202092787 A1 EA 202092787A1 EA 202092787 A EA202092787 A EA 202092787A EA 202092787 A EA202092787 A EA 202092787A EA 202092787 A1 EA202092787 A1 EA 202092787A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- typifarnibus
- synthesis
- methyl
- chlorophenyl
- tipifarnib
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- PLHJCIYEEKOWNM-UHFFFAOYSA-N 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one Chemical compound CN1C=NC=C1C(N)(C=1C=C2C(C=3C=C(Cl)C=CC=3)=CC(=O)N(C)C2=CC=1)C1=CC=C(Cl)C=C1 PLHJCIYEEKOWNM-UHFFFAOYSA-N 0.000 abstract 1
- PLHJCIYEEKOWNM-HHHXNRCGSA-N tipifarnib Chemical compound CN1C=NC=C1[C@](N)(C=1C=C2C(C=3C=C(Cl)C=CC=3)=CC(=O)N(C)C2=CC=1)C1=CC=C(Cl)C=C1 PLHJCIYEEKOWNM-HHHXNRCGSA-N 0.000 abstract 1
- 229950009158 tipifarnib Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862673693P | 2018-05-18 | 2018-05-18 | |
| PCT/US2019/032765 WO2019222565A1 (en) | 2018-05-18 | 2019-05-17 | Synthesis of tipifarnib |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202092787A1 true EA202092787A1 (ru) | 2021-02-09 |
Family
ID=66770583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202092787A EA202092787A1 (ru) | 2018-05-18 | 2019-05-17 | Синтез типифарниба |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11542244B2 (https=) |
| EP (1) | EP3793966A1 (https=) |
| JP (1) | JP2021526513A (https=) |
| KR (1) | KR20210039987A (https=) |
| CN (1) | CN112424149B (https=) |
| AU (1) | AU2019270163A1 (https=) |
| BR (1) | BR112020023559A2 (https=) |
| CA (1) | CA3100706A1 (https=) |
| EA (1) | EA202092787A1 (https=) |
| MX (1) | MX2020012305A (https=) |
| PH (1) | PH12020551956A1 (https=) |
| SG (1) | SG11202011378WA (https=) |
| WO (1) | WO2019222565A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102839264B1 (ko) | 2023-03-07 | 2025-07-29 | 단국대학교 천안캠퍼스 산학협력단 | 티피파르닙을 유효성분으로 포함하는 근감소증 예방 또는 치료용 약학 조성물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2200490C (en) * | 1994-09-23 | 2007-01-09 | Chiroscience Limited | Racemisation and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof |
| AU702594B2 (en) * | 1995-10-13 | 1999-02-25 | Duphar International Research B.V. | Process for the preparation of enantiomerically pure imidazolyl compounds |
| SK283335B6 (sk) | 1995-12-08 | 2003-06-03 | Janssen Pharmaceutica N. V. | (Imidazol-5-yl)metyl-2-chinolinónové deriváty, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické kompozície na ich báze |
| BRPI0208075B8 (pt) * | 2001-03-12 | 2021-05-25 | Janssen Pharmaceutica Nv | processo para a preparação de compostos de imidazol |
| EP1758885B1 (en) * | 2004-05-03 | 2008-06-18 | Janssen Pharmaceutica N.V. | Diastereoselective addition of lithiated n-methylimidazole on sulfinimines |
| JP4917022B2 (ja) * | 2004-05-03 | 2012-04-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ６−ブロモ−４−（３−クロロフェニル）−２−メトキシ−キノリンを用いるジアステレオ選択的合成方法 |
| CA2563807C (en) * | 2004-05-03 | 2012-11-20 | Janssen Pharmaceutica N.V. | Diastereoselective synthesis process for the preparation of imidazole compounds |
| JP6640220B2 (ja) * | 2014-11-21 | 2020-02-05 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | プラジカンテルの製造方法 |
| CN104876856B (zh) | 2015-05-05 | 2017-11-21 | 河北凯力昂生物科技有限公司 | 一种拆分法制备(r)‑(+)‑3‑氨基哌啶二盐酸盐的方法 |
-
2019
- 2019-05-17 AU AU2019270163A patent/AU2019270163A1/en not_active Abandoned
- 2019-05-17 SG SG11202011378WA patent/SG11202011378WA/en unknown
- 2019-05-17 MX MX2020012305A patent/MX2020012305A/es unknown
- 2019-05-17 CN CN201980047803.3A patent/CN112424149B/zh active Active
- 2019-05-17 JP JP2020564572A patent/JP2021526513A/ja not_active Withdrawn
- 2019-05-17 EA EA202092787A patent/EA202092787A1/ru unknown
- 2019-05-17 KR KR1020207036324A patent/KR20210039987A/ko not_active Withdrawn
- 2019-05-17 BR BR112020023559-8A patent/BR112020023559A2/pt not_active Application Discontinuation
- 2019-05-17 US US17/056,745 patent/US11542244B2/en active Active
- 2019-05-17 WO PCT/US2019/032765 patent/WO2019222565A1/en not_active Ceased
- 2019-05-17 EP EP19728818.6A patent/EP3793966A1/en not_active Withdrawn
- 2019-05-17 CA CA3100706A patent/CA3100706A1/en active Pending
-
2020
- 2020-11-16 PH PH12020551956A patent/PH12020551956A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG11202011378WA (en) | 2020-12-30 |
| CN112424149A (zh) | 2021-02-26 |
| WO2019222565A1 (en) | 2019-11-21 |
| MX2020012305A (es) | 2021-03-25 |
| BR112020023559A2 (pt) | 2021-02-09 |
| CN112424149B (zh) | 2023-06-23 |
| EP3793966A1 (en) | 2021-03-24 |
| KR20210039987A (ko) | 2021-04-12 |
| JP2021526513A (ja) | 2021-10-07 |
| US11542244B2 (en) | 2023-01-03 |
| AU2019270163A1 (en) | 2020-12-03 |
| US20210246114A1 (en) | 2021-08-12 |
| CA3100706A1 (en) | 2019-11-21 |
| PH12020551956A1 (en) | 2021-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201892202A1 (ru) | Способы лечения холестатических заболеваний | |
| EA201992128A1 (ru) | Конденсированные имидазопиперидиновые ингибиторы jak | |
| MA51771A (fr) | Procédés de préparation de (1-(3-fluoro-2-(trifluorométhyl)isonicotinyl)pipéridine-4-one) | |
| CY1124085T1 (el) | Κρυσταλλικα αλατα (s)-6-((1-ακετυλπιπεριδιν-4-υλ)αμινο)-ν-(3-(3,4-διυδροϊσοκινολιν-2(1η)-υλ)-2-υδροξυπροπυλ)πυριμιδινο-4-καρβοξαμιδιου | |
| EA201890469A1 (ru) | Соли ингибитора lsd1 | |
| EP4273132A3 (en) | Processes for preparing acc inhibitors and solid forms thereof | |
| EA202090572A1 (ru) | ИНГИБИТОРЫ Rho-АССОЦИИРОВАННОЙ, СОДЕРЖАЩЕЙ СУПЕРСПИРАЛЬ ПРОТЕИНКИНАЗЫ | |
| MY196576A (en) | Amino Pyrimidine SSAO Inhibitors | |
| EP3778605A3 (en) | Lrrk2 inhibitors and methods of making and using the same | |
| MX381487B (es) | Ciertos inhibidores de la proteina quinasa. | |
| SA522431428B1 (ar) | عملية محسّنة لتحضير مشتقات أمينو بيريميدين | |
| SA518400333B1 (ar) | شكل متعدد الأشكال من n- {6-(2-هيدروكسي بروبان-2-يل) -2-[2-(مثيل سلفونيل) إثيل]-2h-إندازول-5-يل}-6-(ثلاثي فلورومثيل) بيريدين-2-كربوكساميد | |
| PH12018500736A1 (en) | Methods for treating multiple sclerosis using pyrimidine and pyridine compounds with btk inhibitory activity | |
| MX393879B (es) | Métodos de preparación de niraparib. | |
| MX2019009501A (es) | Compuestos de amino piridina utiles como inhibidores de ssao. | |
| MX388026B (es) | Compuestos y métodos para modular la tirosina cinasa de bruton. | |
| EA201990678A1 (ru) | Гетероарилкарбоксамидные соединения в качестве ингибиторов ripk2 | |
| CY1125352T1 (el) | Κρυσταλλικες ενωσεις | |
| WO2018067520A3 (en) | Therapeutic agents and methods: | |
| EA201692474A1 (ru) | Производные 1-(циклопент-2-ен-1-ил)-3-(2-гидрокси-3-(арилсульфонил)фенил)мочевины в качестве ингибиторов cxcr2 | |
| DOP2018000103A (es) | Forma cristalina de 2-(2,6-diclorofenil)-1-[(1s,3r)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1h)-il]etanona para tratar enfermedad de parkinson. | |
| EA202193105A1 (ru) | Способы и промежуточные соединения для получения 2-(2,6-дихлорфенил)-1-[(1s,3r)-3-(гидроксиметил)-5-(3-гидрокси-3-метилбутил)-1-метил-3,4-дигидроизохинолин-2(1h)-ил]этенона | |
| EA202092787A1 (ru) | Синтез типифарниба | |
| MY188699A (en) | Processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds | |
| EA202090670A1 (ru) | Способ получения тубулизинов и их промежуточных соединений |