KR20210005146A - 유전자 편집된 t 세포에서의 인간 foxp3의 발현 - Google Patents

유전자 편집된 t 세포에서의 인간 foxp3의 발현 Download PDF

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KR20210005146A
KR20210005146A KR1020207033790A KR20207033790A KR20210005146A KR 20210005146 A KR20210005146 A KR 20210005146A KR 1020207033790 A KR1020207033790 A KR 1020207033790A KR 20207033790 A KR20207033790 A KR 20207033790A KR 20210005146 A KR20210005146 A KR 20210005146A
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sequence
foxp3
nucleic acid
cell
seq
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앤드류 엠. 샤렌버그
데이비드 제이. 롤링스
카렌 소머
유치 치앙 호나케르
이람 에프. 칸
트로이 토거슨
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시애틀 칠드런즈 호스피탈 디/비/에이 시애틀 칠드런즈 리서치 인스티튜트
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KR1020207033790A 2018-04-27 2019-04-25 유전자 편집된 t 세포에서의 인간 foxp3의 발현 Pending KR20210005146A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862663561P 2018-04-27 2018-04-27
US62/663,561 2018-04-27
US201862773414P 2018-11-30 2018-11-30
US62/773,414 2018-11-30
PCT/US2019/029159 WO2019210078A1 (en) 2018-04-27 2019-04-25 Expression of human foxp3 in gene edited t cells

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KR20210005146A true KR20210005146A (ko) 2021-01-13

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US (1) US20210253652A1 (enExample)
EP (1) EP3784689A4 (enExample)
JP (2) JP7575949B2 (enExample)
KR (1) KR20210005146A (enExample)
CN (1) CN112041334A (enExample)
AU (2) AU2019257708B2 (enExample)
CA (1) CA3091491A1 (enExample)
IL (1) IL277036A (enExample)
SG (1) SG11202007877SA (enExample)
WO (1) WO2019210078A1 (enExample)

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CN110139675B (zh) * 2016-10-31 2023-09-29 西雅图儿童医院（Dba西雅图儿童研究所） 用具有工程化稳定的内源性foxp3基因表达的cd4t细胞治疗自身免疫疾病的方法
WO2019210042A1 (en) 2018-04-27 2019-10-31 Seattle Children's Hospital (dba Seattle Children's Research Institute) Expression of foxp3 in edited cd34+ cells
WO2020161122A1 (en) * 2019-02-05 2020-08-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Recombinant vectors suitable for the treatment of ipex syndrome
CA3141159A1 (en) 2019-05-21 2020-11-26 Sangamo Therapeutics, Inc. Controlled transgene expression in regulatory t cells
JP2023501388A (ja) * 2019-11-08 2023-01-18 サンガモ セラピューティクス， インコーポレイテッド 操作された制御性ｔ細胞の生成
EP4103591A4 (en) * 2020-02-13 2024-09-04 The Board of Trustees of the Leland Stanford Junior University Crispr-based foxp3 gene engineered t cells and hematopoietic stem cell precursors to treat ipex syndrome patients
EP4240376A1 (en) * 2020-11-09 2023-09-13 Quell Therapeutics Limited Method for cryopreserving engineered tregs
EP4355879A4 (en) * 2021-06-14 2025-07-23 Kamau Therapeutics Inc METHODS FOR GENETIC MODIFICATION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS FOR ERYTHROCYTE-SPECIFIC EXPRESSION OF THERAPEUTIC PROTEINS
WO2023122099A2 (en) * 2021-12-21 2023-06-29 The Board Of Trustees Of The Leland Stanford Junior University Crispr-based gene editing to preserve splicing and expression of foxp3 isoforms 1 and 2
CN115305237B (zh) * 2022-07-08 2023-07-14 中南大学 一种优化的调节性t细胞的扩增及规模化生产的方法
WO2024127369A1 (en) * 2022-12-16 2024-06-20 LifeEDIT Therapeutics, Inc. Guide rnas that target foxp3 gene and methods of use
WO2025006409A2 (en) * 2023-06-24 2025-01-02 Sonoma Biotherapeutics, Inc. Compositions and methods for engineering cells
WO2025054503A1 (en) * 2023-09-08 2025-03-13 Sonoma Biotherapeutics, Inc. Cells ectopically expressing foxp3

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AU2007347364A1 (en) * 2007-02-21 2008-08-28 Adelaide Research & Innovation Pty Ltd Method for obtaining TREG-cells
ES2883131T3 (es) * 2013-05-29 2021-12-07 Cellectis Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN
WO2016123578A1 (en) * 2015-01-30 2016-08-04 The Regents Of The University Of California Protein delivery in primary hematopoietic cells
AU2016261600B2 (en) * 2015-05-08 2021-09-23 President And Fellows Of Harvard College Universal donor stem cells and related methods
US20190309274A1 (en) * 2016-08-16 2019-10-10 Bluebird Bio, Inc. Il-10 receptor alpha homing endonuclease variants, compositions, and methods of use
WO2018073391A1 (en) * 2016-10-19 2018-04-26 Cellectis Targeted gene insertion for improved immune cells therapy
GB2607227B (en) * 2016-10-27 2023-05-10 Intima Bioscience Inc Viral methods of T cell therapy
CN110139675B (zh) 2016-10-31 2023-09-29 西雅图儿童医院（Dba西雅图儿童研究所） 用具有工程化稳定的内源性foxp3基因表达的cd4t细胞治疗自身免疫疾病的方法
CN109797171A (zh) * 2017-05-08 2019-05-24 北京东方略细胞技术有限公司 经修饰的t细胞、其制备方法及用途
JP7290288B2 (ja) * 2017-08-22 2023-06-13 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 免疫不全及び自己免疫疾患を治療するための、造血幹細胞でｆｏｘｐ３を発現するレンチウイルスベクター
WO2019210042A1 (en) * 2018-04-27 2019-10-31 Seattle Children's Hospital (dba Seattle Children's Research Institute) Expression of foxp3 in edited cd34+ cells

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EP3784689A1 (en) 2021-03-03
AU2024266825A1 (en) 2024-12-12
AU2019257708B2 (en) 2024-08-22
EP3784689A4 (en) 2022-01-19
WO2019210078A1 (en) 2019-10-31
CN112041334A (zh) 2020-12-04
JP2025013879A (ja) 2025-01-28
US20210253652A1 (en) 2021-08-19
CA3091491A1 (en) 2019-10-31
SG11202007877SA (en) 2020-09-29
IL277036A (en) 2020-10-29
JP2021521849A (ja) 2021-08-30
JP7575949B2 (ja) 2024-10-31
AU2019257708A1 (en) 2020-09-03

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