AU2019257708B2 - Expression of human FOXP3 in gene edited T cells - Google Patents

Expression of human FOXP3 in gene edited T cells Download PDF

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AU2019257708B2
AU2019257708B2 AU2019257708A AU2019257708A AU2019257708B2 AU 2019257708 B2 AU2019257708 B2 AU 2019257708B2 AU 2019257708 A AU2019257708 A AU 2019257708A AU 2019257708 A AU2019257708 A AU 2019257708A AU 2019257708 B2 AU2019257708 B2 AU 2019257708B2
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foxp3
sequence
cell
nucleic acid
locus
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AU2019257708A1 (en
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Yuchi Chiang HONAKER
Iram F. KHAN
David J. Rawlings
Andrew M. Scharenberg
Karen SOMMER
Troy TORGERSON
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Seattle Childrens Hospital
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Seattle Childrens Hospital
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    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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AU2019257708A 2018-04-27 2019-04-25 Expression of human FOXP3 in gene edited T cells Active AU2019257708B2 (en)

Priority Applications (1)

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AU2024266825A AU2024266825A1 (en) 2018-04-27 2024-11-22 Expression of human FOXP3 in gene edited T cells

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US201862663561P 2018-04-27 2018-04-27
US62/663,561 2018-04-27
US201862773414P 2018-11-30 2018-11-30
US62/773,414 2018-11-30
PCT/US2019/029159 WO2019210078A1 (en) 2018-04-27 2019-04-25 Expression of human foxp3 in gene edited t cells

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CN112218882A (zh) 2018-04-27 2021-01-12 西雅图儿童医院（Dba西雅图儿童研究所） Foxp3在经编辑的cd34+细胞中的表达
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WO2021163642A2 (en) * 2020-02-13 2021-08-19 The Board Of Trustees Of The Leland Stanford Junior University Crispr-based foxp3 gene engineered t cells and hematopoietic stem cell precursors to treat ipex syndrome patients
TW202227631A (zh) * 2020-11-09 2022-07-16 英商圭爾醫療有限公司 冷凍保存經工程化之調節t細胞(tregs)之方法
EP4355879A4 (en) * 2021-06-14 2025-07-23 Kamau Therapeutics Inc METHODS FOR GENETIC MODIFICATION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS FOR ERYTHROCYTE-SPECIFIC EXPRESSION OF THERAPEUTIC PROTEINS
WO2023122099A2 (en) * 2021-12-21 2023-06-29 The Board Of Trustees Of The Leland Stanford Junior University Crispr-based gene editing to preserve splicing and expression of foxp3 isoforms 1 and 2
CN115305237B (zh) * 2022-07-08 2023-07-14 中南大学 一种优化的调节性t细胞的扩增及规模化生产的方法
EP4634383A1 (en) * 2022-12-16 2025-10-22 Life Edit Therapeutics, Inc. Guide rnas that target foxp3 gene and methods of use
WO2025006409A2 (en) * 2023-06-24 2025-01-02 Sonoma Biotherapeutics, Inc. Compositions and methods for engineering cells
WO2025054503A1 (en) * 2023-09-08 2025-03-13 Sonoma Biotherapeutics, Inc. Cells ectopically expressing foxp3

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WO2019210078A1 (en) 2019-10-31
IL277036A (en) 2020-10-29
US20210253652A1 (en) 2021-08-19
JP7575949B2 (ja) 2024-10-31
KR20210005146A (ko) 2021-01-13
SG11202007877SA (en) 2020-09-29
JP2021521849A (ja) 2021-08-30
CA3091491A1 (en) 2019-10-31
AU2019257708A1 (en) 2020-09-03
EP3784689A1 (en) 2021-03-03
JP2025013879A (ja) 2025-01-28
AU2024266825A1 (en) 2024-12-12
CN112041334A (zh) 2020-12-04
EP3784689A4 (en) 2022-01-19

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