JP7575949B2 - 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 - Google Patents

遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 Download PDF

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JP7575949B2
JP7575949B2 JP2020560338A JP2020560338A JP7575949B2 JP 7575949 B2 JP7575949 B2 JP 7575949B2 JP 2020560338 A JP2020560338 A JP 2020560338A JP 2020560338 A JP2020560338 A JP 2020560338A JP 7575949 B2 JP7575949 B2 JP 7575949B2
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sequence
foxp3
cell
nucleotides
nucleic acid
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JP2021521849A (ja
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エム． シャーレンバーグ，アンドリュー
ジェイ． ローリングス，デイヴィッド
ソマー，カレン
チアン ホナカー，ユーチ
エフ． ハン，イラム
トーガーソン，トロイ
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シアトル チルドレンズ ホスピタル ディー／ビー／エイ シアトル チルドレンズ リサーチ インスティテュート
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JP2020560338A 2018-04-27 2019-04-25 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 Active JP7575949B2 (ja)

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JP2024182444A JP2025013879A (ja) 2018-04-27 2024-10-18 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現

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US201862663561P 2018-04-27 2018-04-27
US62/663,561 2018-04-27
US201862773414P 2018-11-30 2018-11-30
US62/773,414 2018-11-30
PCT/US2019/029159 WO2019210078A1 (en) 2018-04-27 2019-04-25 Expression of human foxp3 in gene edited t cells

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KR (1) KR20210005146A (enExample)
CN (1) CN112041334A (enExample)
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CA (1) CA3091491A1 (enExample)
IL (1) IL277036A (enExample)
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CN110139675B (zh) * 2016-10-31 2023-09-29 西雅图儿童医院（Dba西雅图儿童研究所） 用具有工程化稳定的内源性foxp3基因表达的cd4t细胞治疗自身免疫疾病的方法
WO2019210042A1 (en) 2018-04-27 2019-10-31 Seattle Children's Hospital (dba Seattle Children's Research Institute) Expression of foxp3 in edited cd34+ cells
WO2020161122A1 (en) * 2019-02-05 2020-08-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Recombinant vectors suitable for the treatment of ipex syndrome
CA3141159A1 (en) 2019-05-21 2020-11-26 Sangamo Therapeutics, Inc. Controlled transgene expression in regulatory t cells
JP2023501388A (ja) * 2019-11-08 2023-01-18 サンガモ セラピューティクス， インコーポレイテッド 操作された制御性ｔ細胞の生成
EP4103591A4 (en) * 2020-02-13 2024-09-04 The Board of Trustees of the Leland Stanford Junior University Crispr-based foxp3 gene engineered t cells and hematopoietic stem cell precursors to treat ipex syndrome patients
EP4240376A1 (en) * 2020-11-09 2023-09-13 Quell Therapeutics Limited Method for cryopreserving engineered tregs
EP4355879A4 (en) * 2021-06-14 2025-07-23 Kamau Therapeutics Inc METHODS FOR GENETIC MODIFICATION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS FOR ERYTHROCYTE-SPECIFIC EXPRESSION OF THERAPEUTIC PROTEINS
WO2023122099A2 (en) * 2021-12-21 2023-06-29 The Board Of Trustees Of The Leland Stanford Junior University Crispr-based gene editing to preserve splicing and expression of foxp3 isoforms 1 and 2
CN115305237B (zh) * 2022-07-08 2023-07-14 中南大学 一种优化的调节性t细胞的扩增及规模化生产的方法
WO2024127369A1 (en) * 2022-12-16 2024-06-20 LifeEDIT Therapeutics, Inc. Guide rnas that target foxp3 gene and methods of use
WO2025006409A2 (en) * 2023-06-24 2025-01-02 Sonoma Biotherapeutics, Inc. Compositions and methods for engineering cells
WO2025054503A1 (en) * 2023-09-08 2025-03-13 Sonoma Biotherapeutics, Inc. Cells ectopically expressing foxp3

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US20110123502A1 (en) 2007-02-21 2011-05-26 Barry Simon C Method for obtaining treg-cells
WO2016123578A1 (en) 2015-01-30 2016-08-04 The Regents Of The University Of California Protein delivery in primary hematopoietic cells
WO2018035141A1 (en) 2016-08-16 2018-02-22 Bluebird Bio, Inc. Il-10 receptor alpha homing endonuclease variants, compositions, and methods of use

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AU2016261600B2 (en) * 2015-05-08 2021-09-23 President And Fellows Of Harvard College Universal donor stem cells and related methods
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CN110139675B (zh) 2016-10-31 2023-09-29 西雅图儿童医院（Dba西雅图儿童研究所） 用具有工程化稳定的内源性foxp3基因表达的cd4t细胞治疗自身免疫疾病的方法
CN109797171A (zh) * 2017-05-08 2019-05-24 北京东方略细胞技术有限公司 经修饰的t细胞、其制备方法及用途
JP7290288B2 (ja) * 2017-08-22 2023-06-13 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 免疫不全及び自己免疫疾患を治療するための、造血幹細胞でｆｏｘｐ３を発現するレンチウイルスベクター
WO2019210042A1 (en) * 2018-04-27 2019-10-31 Seattle Children's Hospital (dba Seattle Children's Research Institute) Expression of foxp3 in edited cd34+ cells

Patent Citations (3)

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US20110123502A1 (en) 2007-02-21 2011-05-26 Barry Simon C Method for obtaining treg-cells
WO2016123578A1 (en) 2015-01-30 2016-08-04 The Regents Of The University Of California Protein delivery in primary hematopoietic cells
WO2018035141A1 (en) 2016-08-16 2018-02-22 Bluebird Bio, Inc. Il-10 receptor alpha homing endonuclease variants, compositions, and methods of use

Non-Patent Citations (1)

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Title
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EP3784689A1 (en) 2021-03-03
AU2024266825A1 (en) 2024-12-12
AU2019257708B2 (en) 2024-08-22
EP3784689A4 (en) 2022-01-19
WO2019210078A1 (en) 2019-10-31
CN112041334A (zh) 2020-12-04
JP2025013879A (ja) 2025-01-28
US20210253652A1 (en) 2021-08-19
CA3091491A1 (en) 2019-10-31
SG11202007877SA (en) 2020-09-29
IL277036A (en) 2020-10-29
JP2021521849A (ja) 2021-08-30
AU2019257708A1 (en) 2020-09-03
KR20210005146A (ko) 2021-01-13

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