JP7575949B2 - 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 - Google Patents

遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 Download PDF

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JP7575949B2
JP7575949B2 JP2020560338A JP2020560338A JP7575949B2 JP 7575949 B2 JP7575949 B2 JP 7575949B2 JP 2020560338 A JP2020560338 A JP 2020560338A JP 2020560338 A JP2020560338 A JP 2020560338A JP 7575949 B2 JP7575949 B2 JP 7575949B2
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sequence
foxp3
cell
nucleotides
nucleic acid
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JP2021521849A5 (enExample
JP2021521849A (ja
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エム． シャーレンバーグ，アンドリュー
ジェイ． ローリングス，デイヴィッド
ソマー，カレン
チアン ホナカー，ユーチ
エフ． ハン，イラム
トーガーソン，トロイ
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シアトル チルドレンズ ホスピタル ディー／ビー／エイ シアトル チルドレンズ リサーチ インスティテュート
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JP2020560338A 2018-04-27 2019-04-25 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 Active JP7575949B2 (ja)

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JP2024182444A JP7844581B2 (ja) 2018-04-27 2024-10-18 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現
JP2026059991A JP2026099845A (ja) 2018-04-27 2026-04-01 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現

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US201862663561P 2018-04-27 2018-04-27
US62/663,561 2018-04-27
US201862773414P 2018-11-30 2018-11-30
US62/773,414 2018-11-30
PCT/US2019/029159 WO2019210078A1 (en) 2018-04-27 2019-04-25 Expression of human foxp3 in gene edited t cells

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JP2026059991A Pending JP2026099845A (ja) 2018-04-27 2026-04-01 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現

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JP2026059991A Pending JP2026099845A (ja) 2018-04-27 2026-04-01 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現

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EP (1) EP3784689A4 (enExample)
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KR (1) KR102912481B1 (enExample)
CN (1) CN112041334A (enExample)
AU (2) AU2019257708B2 (enExample)
CA (1) CA3091491A1 (enExample)
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CA3042179A1 (en) 2016-10-31 2018-05-03 Seattle Children's Hospital (dba Seattle Children's Research Institute) Method for treating autoimmune disease using cd4 t-cells with engineered stabilization of expression of endogenous foxp3 gene
SG11202007878UA (en) 2018-04-27 2020-09-29 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Expression of foxp3 in edited cd34+ cells
WO2020161122A1 (en) * 2019-02-05 2020-08-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Recombinant vectors suitable for the treatment of ipex syndrome
JP2022533713A (ja) * 2019-05-21 2022-07-25 サンガモ セラピューティクス， インコーポレイテッド 調節性ｔ細胞における制御された導入遺伝子発現
CA3160113A1 (en) * 2019-11-08 2021-05-14 Sangamo Therapeutics, Inc. Generation of engineered regulatory t cells
EP4103591A4 (en) * 2020-02-13 2024-09-04 The Board of Trustees of the Leland Stanford Junior University Crispr-based foxp3 gene engineered t cells and hematopoietic stem cell precursors to treat ipex syndrome patients
IL302591A (en) * 2020-11-09 2023-07-01 Quell Therapeutics Ltd Method for cryopreservation of transgenic regulatory T cells
WO2022266139A2 (en) * 2021-06-14 2022-12-22 Graphite Bio, Inc. Methods to genetically engineer hematopoietic stem and progenitor cells for red cell specific expression of therapeutic proteins
WO2023122099A2 (en) * 2021-12-21 2023-06-29 The Board Of Trustees Of The Leland Stanford Junior University Crispr-based gene editing to preserve splicing and expression of foxp3 isoforms 1 and 2
CN115305237B (zh) * 2022-07-08 2023-07-14 中南大学 一种优化的调节性t细胞的扩增及规模化生产的方法
WO2024127369A1 (en) * 2022-12-16 2024-06-20 LifeEDIT Therapeutics, Inc. Guide rnas that target foxp3 gene and methods of use
CN121532517A (zh) * 2023-06-24 2026-02-13 索诺玛生物治疗公司 用于对细胞进行工程改造的组合物和方法
CN122055438A (zh) * 2023-09-08 2026-05-15 索诺玛生物治疗公司 异位表达foxp3的细胞
JP7818147B1 (ja) * 2025-01-23 2026-02-20 国立研究開発法人国立がん研究センター エフェクターｔ細胞、およびそれを含む医薬組成物

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WO2016123578A1 (en) 2015-01-30 2016-08-04 The Regents Of The University Of California Protein delivery in primary hematopoietic cells
WO2018035141A1 (en) 2016-08-16 2018-02-22 Bluebird Bio, Inc. Il-10 receptor alpha homing endonuclease variants, compositions, and methods of use

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SG11202007877SA (en) 2020-09-29
AU2024266825A1 (en) 2024-12-12
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CA3091491A1 (en) 2019-10-31
CN112041334A (zh) 2020-12-04
WO2019210078A1 (en) 2019-10-31
KR20210005146A (ko) 2021-01-13
EP3784689A4 (en) 2022-01-19
AU2019257708A1 (en) 2020-09-03
IL277036A (en) 2020-10-29
JP2021521849A (ja) 2021-08-30
KR102912481B1 (ko) 2026-01-15
JP2026099845A (ja) 2026-06-18

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