KR20200076730A - 보로네이트 에스터 유도체의 합성 및 이의 용도 - Google Patents

보로네이트 에스터 유도체의 합성 및 이의 용도 Download PDF

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Publication number
KR20200076730A
KR20200076730A KR1020207015638A KR20207015638A KR20200076730A KR 20200076730 A KR20200076730 A KR 20200076730A KR 1020207015638 A KR1020207015638 A KR 1020207015638A KR 20207015638 A KR20207015638 A KR 20207015638A KR 20200076730 A KR20200076730 A KR 20200076730A
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South Korea
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compound
formula
optionally substituted
group
alkyl
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KR1020207015638A
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English (en)
Korean (ko)
Inventor
서지 헨리 보이어
스콧 제이. 헤커
제라르두스 케이.엠. 베르지즐
페트루스 제이. 헤름센
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멜린타 테라퓨틱스, 인크.
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Publication of KR20200076730A publication Critical patent/KR20200076730A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/46—Ruthenium, rhodium, osmium or iridium
    • B01J23/462—Ruthenium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020207015638A 2017-11-01 2018-10-30 보로네이트 에스터 유도체의 합성 및 이의 용도 Ceased KR20200076730A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762580343P 2017-11-01 2017-11-01
US62/580,343 2017-11-01
PCT/US2018/058143 WO2019089542A1 (en) 2017-11-01 2018-10-30 Synthesis of boronate ester derivatives and uses thereof

Publications (1)

Publication Number Publication Date
KR20200076730A true KR20200076730A (ko) 2020-06-29

Family

ID=66245250

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207015638A Ceased KR20200076730A (ko) 2017-11-01 2018-10-30 보로네이트 에스터 유도체의 합성 및 이의 용도

Country Status (14)

Country Link
US (3) US11999757B2 (https=)
EP (1) EP3704130A4 (https=)
JP (1) JP7480050B2 (https=)
KR (1) KR20200076730A (https=)
CN (2) CN111556872B (https=)
AU (1) AU2018360502B2 (https=)
CA (1) CA3080763A1 (https=)
CL (1) CL2020001143A1 (https=)
CO (1) CO2020006299A2 (https=)
JO (2) JOP20200101B1 (https=)
MX (2) MX2020004425A (https=)
PH (1) PH12020550544A1 (https=)
SG (1) SG11202003762VA (https=)
WO (1) WO2019089542A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111556872B (zh) 2017-11-01 2024-05-10 梅琳塔治疗公司 硼酸酯衍生物的合成及其用途
CN116789689B (zh) * 2023-06-21 2026-03-20 清华大学 硼代萘系化合物及其制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
JP2852545B2 (ja) 1989-11-14 1999-02-03 チッソ株式会社 複数の不斉点を持つ光学活性化合物および製造法
CA2165996C (en) 1995-12-22 2002-01-29 Murray Douglas Bailey Stereoselective preparation of 2-substituted succinic derivatives
FR2745288B1 (fr) 1996-02-27 1998-04-17 Adir Nouveaux derives de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE19917979A1 (de) 1999-04-21 2000-10-26 Clariant Gmbh Verfahren zur Herstellung von substituierten Phenyl-boronsäuren
AU5104300A (en) 1999-06-04 2000-12-28 Kaneka Corporation Processes for the preparation of 5-hydroxy-3-oxopentanoic acid derivatives
DE10032017A1 (de) 2000-07-01 2002-01-10 Clariant Gmbh Verfahren zur Herstellung hochreiner Formylphenylboronsäuren
DE10112401A1 (de) * 2001-03-13 2002-09-19 Degussa Alkohol-Dehydrogenase und deren Verwendung
DE10119274A1 (de) * 2001-04-20 2002-10-31 Juelich Enzyme Products Gmbh Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen
JP4824874B2 (ja) * 2001-07-19 2011-11-30 高砂香料工業株式会社 光学活性γ−ブチロラクトンの製造方法
ES2544579T3 (es) * 2002-07-30 2015-09-01 Takasago International Corporation Procedimiento de producción de un beta-aminoácido ópticamente activo
TWI372725B (en) 2004-01-30 2012-09-21 Semequip Inc Methods of synthesis of isotopically enriched borohydride and methods of synthesis of isotopically enriched boranes
DE102004022397A1 (de) * 2004-05-06 2005-12-01 Consortium für elektrochemische Industrie GmbH Chirale C2-symmetrische Biphenyle, deren Herstellung sowie Metallkomplexe enthaltend diese Liganden und deren Verwendung als Katalysatoren in chirogenen Synthesen
WO2007034909A1 (ja) * 2005-09-22 2007-03-29 Kaneka Corporation （３ｒ，５ｒ）－７－アミノ－３，５－ジヒドロキシヘプタン酸誘導体の製造法
GB2474687A (en) 2009-10-23 2011-04-27 Phoenix Chemicals Ltd A continuous process for the production of (R)-6-cyano-5-hydroxy-3-oxo-hexanoic acid tert-butyl ester (and derivatives)
CA2807546C (en) 2010-08-10 2022-08-23 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
WO2013056163A1 (en) 2011-10-14 2013-04-18 The Regents Of The University Of California Beta-lactamase inhibitors
EP2814483A2 (en) * 2012-02-15 2014-12-24 Rempex Pharmaceuticals, Inc. Methods of treating bacterial infections
CN104395326B (zh) 2012-08-20 2017-04-05 玛耐科股份有限公司 二取代硼酸衍生物的制造方法和新型二取代硼酸衍生物
CN102965403A (zh) 2012-11-19 2013-03-13 苏州汉酶生物技术有限公司 (3r,5s)-6-氯-3,5-二羟基己酸叔丁酯的生物制备方法
AU2013355110B2 (en) * 2012-12-07 2017-11-09 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
PT3369724T (pt) 2013-11-05 2021-02-10 Bracco Imaging Spa Processo para a preparação de iopamidol
ES2750805T3 (es) * 2014-05-05 2020-03-27 Rempex Pharmaceuticals Inc Síntesis de sales de boronato y usos de las mismas
CN111556872B (zh) 2017-11-01 2024-05-10 梅琳塔治疗公司 硼酸酯衍生物的合成及其用途

Also Published As

Publication number Publication date
SG11202003762VA (en) 2020-05-28
US20190127396A1 (en) 2019-05-02
JOP20200101B1 (ar) 2024-12-22
CA3080763A1 (en) 2019-05-09
US11999757B2 (en) 2024-06-04
EP3704130A1 (en) 2020-09-09
WO2019089542A1 (en) 2019-05-09
MX2020004425A (es) 2020-08-06
AU2018360502B2 (en) 2024-05-02
MX2023000529A (es) 2023-02-13
JP2021501205A (ja) 2021-01-14
CN118388347A (zh) 2024-07-26
US20200308197A1 (en) 2020-10-01
JOP20200101A1 (ar) 2022-10-30
JP7480050B2 (ja) 2024-05-09
JOP20240234A1 (ar) 2024-10-20
US20240279248A1 (en) 2024-08-22
CN111556872B (zh) 2024-05-10
EP3704130A4 (en) 2021-07-07
CN111556872A (zh) 2020-08-18
CL2020001143A1 (es) 2020-10-30
CO2020006299A2 (es) 2020-06-09
AU2018360502A1 (en) 2020-06-04
BR112020008498A2 (pt) 2020-10-20
PH12020550544A1 (en) 2021-03-22

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