CL2020001143A1 - Síntesis de compuestos derivados de éster de boronato y sus usos. - Google Patents

Síntesis de compuestos derivados de éster de boronato y sus usos.

Info

Publication number
CL2020001143A1
CL2020001143A1 CL2020001143A CL2020001143A CL2020001143A1 CL 2020001143 A1 CL2020001143 A1 CL 2020001143A1 CL 2020001143 A CL2020001143 A CL 2020001143A CL 2020001143 A CL2020001143 A CL 2020001143A CL 2020001143 A1 CL2020001143 A1 CL 2020001143A1
Authority
CL
Chile
Prior art keywords
synthesis
compounds derived
boronate ester
reduction
formula
Prior art date
Application number
CL2020001143A
Other languages
English (en)
Inventor
Serge Henri Boyer
Scott J Hecker
Gerardus K M Verzijl
Petrus J Hermsen
Original Assignee
Melinta Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melinta Therapeutics Inc filed Critical Melinta Therapeutics Inc
Publication of CL2020001143A1 publication Critical patent/CL2020001143A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/46—Ruthenium, rhodium, osmium or iridium
    • B01J23/462—Ruthenium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)

Abstract

SE DIVULGAN MÉTODOS PARA LA PREPARACIÓN DE DERIVADOS DE BORONATO EN LA SÍNTESIS DE COMPUESTOS ANTIMICROBIANOS Y SUS USOS. SE DIVULGA UN MÉTODO PARA PREPARAR UN COMPUESTO DE FÓRMULA (B) AL REDUCIR EL GRUPO CETONA DEL COMPUESTO CETO-ÉSTER DE FÓRMULA (A), Y LA REDUCCIÓN SE PUEDE REALIZAR USANDO UN SISTEMA CATALIZADOR BASADO EN RUTENIO O USANDO UN SISTEMA DE BIO-REDUCCIÓN DE ALCOHOL DESHIDROGENASA.
CL2020001143A 2017-11-01 2020-04-30 Síntesis de compuestos derivados de éster de boronato y sus usos. CL2020001143A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762580343P 2017-11-01 2017-11-01

Publications (1)

Publication Number Publication Date
CL2020001143A1 true CL2020001143A1 (es) 2020-10-30

Family

ID=66245250

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020001143A CL2020001143A1 (es) 2017-11-01 2020-04-30 Síntesis de compuestos derivados de éster de boronato y sus usos.

Country Status (15)

Country Link
US (3) US11999757B2 (es)
EP (1) EP3704130A4 (es)
JP (1) JP7480050B2 (es)
KR (1) KR20200076730A (es)
CN (2) CN111556872B (es)
AU (1) AU2018360502B2 (es)
BR (1) BR112020008498A2 (es)
CA (1) CA3080763A1 (es)
CL (1) CL2020001143A1 (es)
CO (1) CO2020006299A2 (es)
JO (1) JOP20200101A1 (es)
MX (2) MX2020004425A (es)
PH (1) PH12020550544A1 (es)
SG (1) SG11202003762VA (es)
WO (1) WO2019089542A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019089542A1 (en) 2017-11-01 2019-05-09 Rempex Pharmaceuticals, Inc. Synthesis of boronate ester derivatives and uses thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
JP2852545B2 (ja) 1989-11-14 1999-02-03 チッソ株式会社 複数の不斉点を持つ光学活性化合物および製造法
CA2165996C (en) 1995-12-22 2002-01-29 Murray Douglas Bailey Stereoselective preparation of 2-substituted succinic derivatives
FR2745288B1 (fr) 1996-02-27 1998-04-17 Adir Nouveaux derives de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE19917979A1 (de) 1999-04-21 2000-10-26 Clariant Gmbh Verfahren zur Herstellung von substituierten Phenyl-boronsäuren
HUP0103788A3 (en) 1999-06-04 2003-05-28 Kaneka Corp Processes for the preparation of 5-hydroxy-3-oxopentanoic acid derivatives
DE10032017A1 (de) 2000-07-01 2002-01-10 Clariant Gmbh Verfahren zur Herstellung hochreiner Formylphenylboronsäuren
DE10112401A1 (de) * 2001-03-13 2002-09-19 Degussa Alkohol-Dehydrogenase und deren Verwendung
DE10119274A1 (de) * 2001-04-20 2002-10-31 Juelich Enzyme Products Gmbh Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen
ES2544579T3 (es) * 2002-07-30 2015-09-01 Takasago International Corporation Procedimiento de producción de un beta-aminoácido ópticamente activo
TWI372725B (en) 2004-01-30 2012-09-21 Semequip Inc Methods of synthesis of isotopically enriched borohydride and methods of synthesis of isotopically enriched boranes
DE102004022397A1 (de) * 2004-05-06 2005-12-01 Consortium für elektrochemische Industrie GmbH Chirale C2-symmetrische Biphenyle, deren Herstellung sowie Metallkomplexe enthaltend diese Liganden und deren Verwendung als Katalysatoren in chirogenen Synthesen
WO2007034909A1 (ja) * 2005-09-22 2007-03-29 Kaneka Corporation （３ｒ，５ｒ）－７－アミノ－３，５－ジヒドロキシヘプタン酸誘導体の製造法
GB2474687A (en) 2009-10-23 2011-04-27 Phoenix Chemicals Ltd A continuous process for the production of (R)-6-cyano-5-hydroxy-3-oxo-hexanoic acid tert-butyl ester (and derivatives)
HUE048859T2 (hu) 2010-08-10 2020-08-28 Rempex Pharmaceuticals Inc Gyûrûs bórsavészter származékok, eljárás elõállításukra, és terápiás alkalmazásuk
WO2013056163A1 (en) * 2011-10-14 2013-04-18 The Regents Of The University Of California Beta-lactamase inhibitors
EP2814483A2 (en) * 2012-02-15 2014-12-24 Rempex Pharmaceuticals, Inc. Methods of treating bacterial infections
CN104395326B (zh) 2012-08-20 2017-04-05 玛耐科股份有限公司 二取代硼酸衍生物的制造方法和新型二取代硼酸衍生物
CN102965403A (zh) 2012-11-19 2013-03-13 苏州汉酶生物技术有限公司 (3r,5s)-6-氯-3,5-二羟基己酸叔丁酯的生物制备方法
KR102147420B1 (ko) * 2012-12-07 2020-08-25 베나토알엑스 파마슈티컬스, 인크. 베타-락타마제 억제제
LT3066071T (lt) 2013-11-05 2018-09-10 Bracco Imaging S.P.A. Jopamidolio gamybos būdas
EP3140310B1 (en) * 2014-05-05 2019-08-07 Rempex Pharmaceuticals, Inc. Synthesis of boronate salts and uses thereof
WO2019089542A1 (en) 2017-11-01 2019-05-09 Rempex Pharmaceuticals, Inc. Synthesis of boronate ester derivatives and uses thereof

Also Published As

Publication number Publication date
BR112020008498A2 (pt) 2020-10-20
JP2021501205A (ja) 2021-01-14
KR20200076730A (ko) 2020-06-29
US11999757B2 (en) 2024-06-04
MX2023000529A (es) 2023-02-13
US20200308197A1 (en) 2020-10-01
CN118388347A (zh) 2024-07-26
WO2019089542A1 (en) 2019-05-09
AU2018360502B2 (en) 2024-05-02
AU2018360502A1 (en) 2020-06-04
PH12020550544A1 (en) 2021-03-22
EP3704130A1 (en) 2020-09-09
JOP20200101A1 (ar) 2022-10-30
CO2020006299A2 (es) 2020-06-09
CN111556872B (zh) 2024-05-10
JP7480050B2 (ja) 2024-05-09
EP3704130A4 (en) 2021-07-07
SG11202003762VA (en) 2020-05-28
US20190127396A1 (en) 2019-05-02
US20240279248A1 (en) 2024-08-22
MX2020004425A (es) 2020-08-06
CN111556872A (zh) 2020-08-18
CA3080763A1 (en) 2019-05-09

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