JOP20200101A1 - تخليق مشتقات إستر بورونات واستخداماتها - Google Patents

تخليق مشتقات إستر بورونات واستخداماتها

Info

Publication number
JOP20200101A1
JOP20200101A1 JOP/2020/0101A JOP20200101A JOP20200101A1 JO P20200101 A1 JOP20200101 A1 JO P20200101A1 JO P20200101 A JOP20200101 A JO P20200101A JO P20200101 A1 JOP20200101 A1 JO P20200101A1
Authority
JO
Jordan
Prior art keywords
synthesis
ester derivatives
boronate ester
formula
disclosed
Prior art date
Application number
JOP/2020/0101A
Other languages
English (en)
Inventor
Serge Henri Boyer
Scott J Hecker
Petrus J Hermsen
Gerardus K M Verzijl
Original Assignee
Melinta Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melinta Therapeutics Inc filed Critical Melinta Therapeutics Inc
Publication of JOP20200101A1 publication Critical patent/JOP20200101A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/46—Ruthenium, rhodium, osmium or iridium
    • B01J23/462—Ruthenium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen

Abstract

يتعلق الاختراع بالكشف في هذا الطلب عن طرق لتحضير مشتقات البورونات في تخليق مركبات مضادة للميكروبات واستخداماتها. يتضمن كذلك الكشف بهذا الطلب طريقة لتصنيع مركب له الصيغة (B) بواسطة اختزال مجموعة الكيتون من مركب الكيتو-إستر الذي له الصيغة (A)، ويمكن أن يتم إجراء الاختزال باستخدام نظام محفز أساسه الروثينيوم أو باستخدام نظام اختزال حيوي من ديهيدروجيناز كحول. الشكل 1
JOP/2020/0101A 2017-11-01 2018-10-30 تخليق مشتقات إستر بورونات واستخداماتها JOP20200101A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762580343P 2017-11-01 2017-11-01
PCT/US2018/058143 WO2019089542A1 (en) 2017-11-01 2018-10-30 Synthesis of boronate ester derivatives and uses thereof

Publications (1)

Publication Number Publication Date
JOP20200101A1 true JOP20200101A1 (ar) 2022-10-30

Family

ID=66245250

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2020/0101A JOP20200101A1 (ar) 2017-11-01 2018-10-30 تخليق مشتقات إستر بورونات واستخداماتها

Country Status (15)

Country Link
US (2) US20200308197A1 (ar)
EP (1) EP3704130A4 (ar)
JP (1) JP2021501205A (ar)
KR (1) KR20200076730A (ar)
CN (1) CN111556872A (ar)
AU (1) AU2018360502A1 (ar)
BR (1) BR112020008498A2 (ar)
CA (1) CA3080763A1 (ar)
CL (1) CL2020001143A1 (ar)
CO (1) CO2020006299A2 (ar)
JO (1) JOP20200101A1 (ar)
MX (2) MX2020004425A (ar)
PH (1) PH12020550544A1 (ar)
SG (1) SG11202003762VA (ar)
WO (1) WO2019089542A1 (ar)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
DE10119274A1 (de) * 2001-04-20 2002-10-31 Juelich Enzyme Products Gmbh Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen
EP1386901B1 (en) * 2002-07-30 2015-07-01 Takasago International Corporation Method for producing an optically active beta-amino acid
DE102004022397A1 (de) * 2004-05-06 2005-12-01 Consortium für elektrochemische Industrie GmbH Chirale C2-symmetrische Biphenyle, deren Herstellung sowie Metallkomplexe enthaltend diese Liganden und deren Verwendung als Katalysatoren in chirogenen Synthesen
WO2007034909A1 (ja) * 2005-09-22 2007-03-29 Kaneka Corporation （３ｒ，５ｒ）－７－アミノ－３，５－ジヒドロキシヘプタン酸誘導体の製造法
CN103180328B (zh) * 2010-08-10 2016-10-26 莱姆派克斯制药公司 环硼酸酯衍生物及其治疗用途
WO2013056163A1 (en) * 2011-10-14 2013-04-18 The Regents Of The University Of California Beta-lactamase inhibitors
WO2013122888A2 (en) * 2012-02-15 2013-08-22 Rempex Pharmaceuticals, Inc. Methods of treating bacterial infections
US9422314B2 (en) * 2012-12-07 2016-08-23 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
HUE046836T2 (hu) * 2014-05-05 2020-03-30 Rempex Pharmaceuticals Inc Boronát sók szintézise és alkalmazásuk

Also Published As

Publication number Publication date
CN111556872A (zh) 2020-08-18
JP2021501205A (ja) 2021-01-14
MX2020004425A (es) 2020-08-06
CL2020001143A1 (es) 2020-10-30
KR20200076730A (ko) 2020-06-29
CA3080763A1 (en) 2019-05-09
US20190127396A1 (en) 2019-05-02
SG11202003762VA (en) 2020-05-28
MX2023000529A (es) 2023-02-13
US20200308197A1 (en) 2020-10-01
PH12020550544A1 (en) 2021-03-22
BR112020008498A2 (pt) 2020-10-20
EP3704130A1 (en) 2020-09-09
AU2018360502A1 (en) 2020-06-04
WO2019089542A1 (en) 2019-05-09
EP3704130A4 (en) 2021-07-07
CO2020006299A2 (es) 2020-06-09

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JOP20200101A1 (ar) تخليق مشتقات إستر بورونات واستخداماتها