KR20200070236A - 면역치료제로서의 pd1-특이적 키메라 항원 수용체 - Google Patents

면역치료제로서의 pd1-특이적 키메라 항원 수용체 Download PDF

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KR20200070236A
KR20200070236A KR1020207009640A KR20207009640A KR20200070236A KR 20200070236 A KR20200070236 A KR 20200070236A KR 1020207009640 A KR1020207009640 A KR 1020207009640A KR 20207009640 A KR20207009640 A KR 20207009640A KR 20200070236 A KR20200070236 A KR 20200070236A
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cells
chpd1
domain
car
cell
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아모렛 바버
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롱우드 유니버시티
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KR1020207009640A 2017-09-26 2018-09-26 면역치료제로서의 pd1-특이적 키메라 항원 수용체 Ceased KR20200070236A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762563336P 2017-09-26 2017-09-26
US62/563,336 2017-09-26
PCT/US2018/052799 WO2019067504A1 (en) 2017-09-26 2018-09-26 SPECIFIC CHIMERIC ANTIGEN RECEPTOR AT PD-1 AS IMMUNOTHERAPY

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KR20200070236A true KR20200070236A (ko) 2020-06-17

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KR1020207009640A Ceased KR20200070236A (ko) 2017-09-26 2018-09-26 면역치료제로서의 pd1-특이적 키메라 항원 수용체

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US (2) US11559549B2 (enExample)
EP (1) EP3688143A4 (enExample)
JP (1) JP2020536531A (enExample)
KR (1) KR20200070236A (enExample)
CN (1) CN111433354A (enExample)
AU (1) AU2018339528A1 (enExample)
CA (1) CA3077187A1 (enExample)
MX (1) MX2020007357A (enExample)
WO (1) WO2019067504A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022211376A1 (ko) * 2021-04-01 2022-10-06 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
WO2022220433A1 (ko) * 2021-04-16 2022-10-20 주식회사 이뮤노로지컬디자이닝랩 Programmed death-ligand 1(pd-l1)에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180019725A (ko) * 2015-06-23 2018-02-26 메모리얼 슬로안-케터링 캔서 센터 신규의 피디 1 면역 조절제
WO2019067504A1 (en) 2017-09-26 2019-04-04 Longwood University SPECIFIC CHIMERIC ANTIGEN RECEPTOR AT PD-1 AS IMMUNOTHERAPY
KR20230010228A (ko) * 2020-05-08 2023-01-18 시애틀 칠드런즈 호스피탈 디/비/에이 시애틀 칠드런즈 리서치 인스티튜트 자연 살해 세포를 표적으로 하는 키메라 항원 수용체 (cars)
CA3240185A1 (en) * 2021-12-06 2023-06-15 Vycellix, Inc. Chimeric switch receptors in nk cells
EP4551246A1 (en) 2022-07-05 2025-05-14 Neomics Pharmaceuticals LLC Chimeric antigen receptor comprising bcma nanobody linked to a chimeric intracellular signaling domain
CN118359727A (zh) * 2023-01-17 2024-07-19 上海以慈生物科技有限公司 突变的pd1胞外域片段及含有该片段的car和nk细胞
WO2025059162A1 (en) 2023-09-11 2025-03-20 Dana-Farber Cancer Institute, Inc. Car-engager containing il-2 variants to enhance the functionality of car t cells

Family Cites Families (13)

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PH12013501201A1 (en) * 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
EA201490364A1 (ru) * 2011-07-29 2014-08-29 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Костимулирующие рецепторы-переключатели
JP6788573B6 (ja) * 2014-04-10 2020-12-16 シアトル チルドレンズ ホスピタル, ディービーエー シアトル チルドレンズ リサーチ インスティテュート メトトレキサートによる選択と組み合わせたSleeping Beautyトランスポゾンによる遺伝子改変T細胞の製造
US10479975B2 (en) * 2014-06-06 2019-11-19 Bluebird Bio, Inc. Methods of making T cell compositions
WO2016028896A1 (en) 2014-08-19 2016-02-25 Novartis Ag Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment
BR122021000068A8 (pt) * 2014-10-27 2023-05-02 Hutchinson Fred Cancer Res Composições e usos em métodos para estimular a eficácia de imunoterapia celular adotiva
EP3089761B1 (en) * 2015-03-02 2019-06-12 Innovative Cellular Therapeutics Co., Ltd. Reducing immune tolerance induced by pd l1
CN106350533B (zh) * 2015-10-09 2020-07-17 上海宇研生物技术有限公司 Anti-PD-L1-CAR-T及其制备方法和应用
AU2016341966A1 (en) * 2015-10-20 2018-05-10 Kite Pharma, Inc. Methods of preparing T cells for T cell therapy
CN106399255B (zh) * 2016-04-13 2019-10-18 阿思科力(苏州)生物科技有限公司 Pd-1 car-t细胞及其制备方法和应用
IL320149A (en) 2017-03-16 2025-06-01 Alpine Immune Sciences Inc Pd-l1 variant immunomodulatory proteins and uses thereof
WO2019067504A1 (en) 2017-09-26 2019-04-04 Longwood University SPECIFIC CHIMERIC ANTIGEN RECEPTOR AT PD-1 AS IMMUNOTHERAPY
CN108384795A (zh) * 2017-10-13 2018-08-10 江苏西迪尔生物技术有限公司 作用于tme免疫效应细胞的人工合成基因及验证方法和应用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022211376A1 (ko) * 2021-04-01 2022-10-06 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
WO2022220433A1 (ko) * 2021-04-16 2022-10-20 주식회사 이뮤노로지컬디자이닝랩 Programmed death-ligand 1(pd-l1)에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도

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CN111433354A (zh) 2020-07-17
WO2019067504A1 (en) 2019-04-04
CA3077187A1 (en) 2019-04-04
US20230293583A1 (en) 2023-09-21
JP2020536531A (ja) 2020-12-17
MX2020007357A (es) 2021-08-11
US11559549B2 (en) 2023-01-24
AU2018339528A1 (en) 2020-04-16
EP3688143A1 (en) 2020-08-05
US20200281974A1 (en) 2020-09-10
EP3688143A4 (en) 2021-09-22

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