KR20200051776A - 베타-히드록시 헤테로사이클릭 아민 및 과혈당증의 치료에서의 이의 용도 - Google Patents

베타-히드록시 헤테로사이클릭 아민 및 과혈당증의 치료에서의 이의 용도 Download PDF

Info

Publication number
KR20200051776A
KR20200051776A KR1020207010468A KR20207010468A KR20200051776A KR 20200051776 A KR20200051776 A KR 20200051776A KR 1020207010468 A KR1020207010468 A KR 1020207010468A KR 20207010468 A KR20207010468 A KR 20207010468A KR 20200051776 A KR20200051776 A KR 20200051776A
Authority
KR
South Korea
Prior art keywords
compound
methanol
independently
optionally substituted
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020207010468A
Other languages
English (en)
Korean (ko)
Inventor
벤자민 펠크만
토레 벵트손
Original Assignee
아트로기 에이비
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아트로기 에이비 filed Critical 아트로기 에이비
Publication of KR20200051776A publication Critical patent/KR20200051776A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
KR1020207010468A 2017-09-13 2018-09-13 베타-히드록시 헤테로사이클릭 아민 및 과혈당증의 치료에서의 이의 용도 Ceased KR20200051776A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1714740.6A GB201714740D0 (en) 2017-09-13 2017-09-13 New compounds and uses
GB1714740.6 2017-09-13
PCT/GB2018/052593 WO2019053425A1 (en) 2017-09-13 2018-09-13 BETA-HYDROXY HETEROCYCLIC AMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCEMIA

Publications (1)

Publication Number Publication Date
KR20200051776A true KR20200051776A (ko) 2020-05-13

Family

ID=60117153

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207010468A Ceased KR20200051776A (ko) 2017-09-13 2018-09-13 베타-히드록시 헤테로사이클릭 아민 및 과혈당증의 치료에서의 이의 용도

Country Status (13)

Country Link
US (1) US11427539B2 (enExample)
EP (1) EP3681862B1 (enExample)
JP (1) JP7346388B2 (enExample)
KR (1) KR20200051776A (enExample)
CN (1) CN111164072A (enExample)
AU (1) AU2018332145A1 (enExample)
BR (1) BR112020005064A2 (enExample)
CA (1) CA3075705A1 (enExample)
GB (1) GB201714740D0 (enExample)
IL (1) IL273171A (enExample)
MX (1) MX2020002824A (enExample)
RU (1) RU2020108488A (enExample)
WO (1) WO2019053425A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201903832D0 (en) 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods
GB201903827D0 (en) * 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods
GB202015044D0 (en) * 2020-09-23 2020-11-04 Atrogi Ab New compounds and methods
GB202015035D0 (en) * 2020-09-23 2020-11-04 Atrogi Ab New compounds and methods
CA3196167A1 (en) * 2020-11-19 2022-05-27 Jiaxin Yu Beta adrenergic agonist and methods of using the same
KR20250161027A (ko) * 2023-03-29 2025-11-14 아트로기 에이비 과혈당증 및 과혈당증을 특징으로 하는 장애의 치료에 사용하기 위한 헤테로사이클로알킬 베타-하이드록시 알킬 아민
GB202304604D0 (en) * 2023-03-29 2023-05-10 Atrogi Ab New compounds and medical uses thereof

Family Cites Families (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE45721C (enExample)
DE638650C (de) 1934-06-08 1936-11-20 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von 3, 4-Dioxyphenylmonoalkylaminobutanolen-1
US2308232A (en) 1939-01-17 1943-01-12 Scheuing Georg Isopropylaminomethyl-(3, 4-dioxyphenyl) carbinol
US2460144A (en) 1946-04-11 1949-01-25 Sterling Drug Inc Hydroxyphenyl alkanolamines
FR1165845A (fr) 1955-05-28 1958-10-29 Philips Nv Amines secondaires portant des substituants et leur préparation
FR1324914A (fr) 1961-01-11 1963-04-26 Philips Nv Procédé de préparation d'aralkylamines substituées optiquement actives
DE1275069B (de) 1960-02-15 1968-08-14 Boehringer Sohn Ingelheim 1-(3', 5'-Dihydroxyphenyl)-1-hydroxy-2-isopropylaminoalkane und Verfahren zu ihrer Herstellung
NL6401871A (enExample) 1964-02-27 1965-08-30
SE335359B (enExample) 1966-10-19 1971-05-24 Draco Ab
AT285583B (de) 1968-10-10 1970-11-10 Chemie Linz Ag Verfahren zur Herstellung von N,N'-bis-[2-(3',4'-Dihydroxyphenyl)-2-hydroxyäthyl]-hexamethylendiamin und seinen Salzen
NO129903B (enExample) 1969-04-01 1974-06-10 Sterling Drug Inc
GB1321701A (en) 1969-10-01 1973-06-27 Continental Pharma Amino-alcohols their salts and process for prepairing the same
US3910934A (en) * 1970-05-21 1975-10-07 Minnesota Mining & Mfg Process for the preparation of {60 -(hydroxy and alkoxy substituted)phenyl-{60 -(2-piperidinyl)-methanols
GB1298494A (en) 1970-06-17 1972-12-06 Allen & Hanburys Ltd Phenylethanolamine derivatives
DE2157040A1 (de) 1971-11-17 1973-05-24 Thomae Gmbh Dr K Neues verfahren zur herstellung von 4-amino-3,5-dihalogen-phenyl-aethanolaminen
US3801631A (en) 1972-02-16 1974-04-02 Mead Johnson & Co 2'-hydroxy-5'-(1-hydroxy-2-(2-methyl-1-phenyl-2-propylamino)ethyl)meth-anesulfonanilide and its salts
DE2300614A1 (de) 1973-01-08 1974-07-18 Thomae Gmbh Dr K Neue optisch aktive verbindungen
DE2259282A1 (de) 1972-12-04 1974-06-12 Thomae Gmbh Dr K Neue aminoaethanole
US4119710A (en) 1972-12-18 1978-10-10 Boehringer Ingelheim Gmbh Bronchospasmolytic 1-(p-amino-phenyl)-2-amino-ethanols-(1) and salts
US3910933A (en) * 1973-10-19 1975-10-07 Smithkline Corp 3-Substituted-4-hydroxyphenyl-2-piperidylcarbinols
US3985887A (en) 1973-10-19 1976-10-12 Smithkline Corporation 3-Substituted-4-hydroxyphenyl-2-piperidylcarbinols as β-adrenergic stimulants
JPS539227B2 (enExample) 1973-12-26 1978-04-04
DE2413102C3 (de) 1974-03-19 1980-09-11 C.H. Boehringer Sohn, 6507 Ingelheim Verfahren zur Herstellung von l-(3,5-Dihydroxyphenyl)-t-hydroxy-2- eckige Klammer auf 1-methyl-2-(4-hydroxyphenyl)- äthyl] -aminoäthan
CA1030146A (en) 1974-04-18 1978-04-25 American Home Products Corporation Thiophene ethanolamines
NO753594L (enExample) 1974-10-30 1976-05-03 Scherico Ltd
US3952101A (en) 1975-04-14 1976-04-20 Smithkline Corporation α-Amino methyl-5-hydroxy-2-pyridinemethanols
CH624395A5 (enExample) 1976-01-08 1981-07-31 Ciba Geigy Ag
JPS6048503B2 (ja) 1976-02-27 1985-10-28 興和株式会社 新規な１−フエニル−２−アミノエタノ−ル誘導体
JPS609713B2 (ja) 1976-10-08 1985-03-12 大塚製薬株式会社 カルボスチリル誘導体
AR214005A1 (es) 1977-05-02 1979-04-11 Pfizer Procedimiento para preparar 2-hidroximetil-3-hidroxi-6-(1-hidroxi-2-t-butilaminoetil)piridina
NZ187066A (en) 1977-05-03 1981-02-11 Hoffmann La Roche 4-(3-substitutedamino-2-hydroxypropoxy)-benzimidazolidin-2-(ones or thiones)
DE2838923A1 (de) 1978-09-07 1980-04-03 Thomae Gmbh Dr K Verwendung von phenylaethanolaminen als antiphlogistica
FR2436779A1 (fr) 1978-09-22 1980-04-18 Pharmindustrie Derives de pyrrolidine-2 methanol utilisables comme medicaments
EP0023385B1 (en) 1979-06-16 1982-12-15 Beecham Group Plc Ethanamine derivatives, their preparation and use in pharmaceutical compositions
FR2460929A1 (fr) 1979-07-06 1981-01-30 Roussel Uclaf Nouveaux derives de l'a-phenyl 2-pyrrolidinemethanol et leur sels, procede de preparation, application a titre de medicaments et compositions les renfermant
JPS5655355A (en) 1979-10-15 1981-05-15 Paamakemu Asia:Kk Preparation of alkylenediamine derivative
FR2486074A1 (fr) 1979-12-14 1982-01-08 Lafon Labor Derives de fluorophenacyl-amine, leur procede de preparation et leur application en therapeutique
DE3163871D1 (en) 1980-07-09 1984-07-05 Draco Ab 1-(dihydroxyphenyl)-2-amino-ethanol derivatives; preparation, compositions and intermediates
IL70813A (en) 1983-01-31 1987-10-30 Lilly Co Eli Animal feed comprising certain phenethanolamine derivatives and 1-phenyl-2-(1-methyl-3-(4-nitrophenyl)propylamino)ethanol hydrochloride
EP0128120A3 (de) 1983-06-02 1985-11-13 Ciba-Geigy Ag Trisubstituierte Oxazolidinone
ES8502099A1 (es) 1983-08-02 1984-12-16 Espanola Farma Therapeut Procedimiento de obtencion de nuevos compuestos derivados de la difenil-metilen-etilamina.
CA1249992A (en) 1983-11-10 1989-02-14 Marcel Muller Oxazolidines
GB2151612B (en) 1983-11-25 1988-08-03 Lafon Labor The use of the family of 2-amino-1-(methoxyphenyl)-1- ethanol derivatives for the manufacture of a medicament for use as a vasodilating agent
US4614746A (en) 1985-03-21 1986-09-30 American Cyanamid Company 5-fluorobenzonitrile derivatives for increasing the lean meat to fat ratio and/or enhancing the growth rate of warm-blooded animals
DE3615293A1 (de) 1986-05-06 1987-11-12 Bayer Ag Verwendung von heteroarylethylaminen zur leistungsfoerderung bei tieren, heteroarylethylamine und verfahren zu ihrer herstellung
GB8714901D0 (en) 1986-07-23 1987-07-29 Ici Plc Amide derivatives
IE60964B1 (en) 1986-12-11 1994-09-07 Roussel Uclaf Zootechnical compositions containing a beta-adrenergic
DK123788A (da) 1987-03-10 1988-09-11 Beecham Group Plc Morpholin-derivater
EP0303546B1 (fr) 1987-08-12 1994-12-28 Sanofi Procédé pour la O-alkylation de N-(hydroxy)aralkylphényléthanolamines
US5019578A (en) 1987-11-27 1991-05-28 Merck & Co., Inc. β-adrenergic agonists
FR2647310B1 (fr) 1989-05-29 1992-01-17 Roussel Uclaf Utilisation de beta-adrenergiques pour la fabrication de compositions zootechniques
IE65511B1 (en) 1989-12-29 1995-11-01 Sanofi Sa New phenylethanolaminomethyltetralins
JP3085705B2 (ja) 1990-01-05 2000-09-11 セプラカー・インコーポレーテツド 喘息の治療のための光学的純粋ｒ（−）アルブテロール
US5061727A (en) 1990-05-04 1991-10-29 American Cyanamid Company Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles
GB9107196D0 (en) 1991-04-05 1991-05-22 Sandoz Ag Improvements in or relating to organic compounds
NO179246C (no) 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
IL104567A (en) 1992-02-03 1997-03-18 Fujisawa Pharmaceutical Co Ethanolamine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US5451677A (en) 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
US5776983A (en) 1993-12-21 1998-07-07 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
US5705515A (en) 1994-04-26 1998-01-06 Merck & Co., Inc. Substituted sulfonamides as selective β-3 agonists for the treatment of diabetes and obesity
US5726165A (en) 1994-07-29 1998-03-10 Smithkline Beecham P.L.C. Derivatives of 4-(2-aminoethyl)phenoxymethyl-phosphonic and -phosphinic acid and pharmaceutical and veterinary uses therefor
US5541204A (en) 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
WO1997025311A1 (en) 1996-01-10 1997-07-17 Asahi Kasei Kogyo Kabushiki Kaisha Novel tricyclic compounds and drug compositions containing the same
WO1998022480A1 (en) 1996-11-18 1998-05-28 Smithkline Beecham Plc Phosphorus containing aryloxy or arylthio propanolamine derivatives
AU728812B2 (en) 1997-01-28 2001-01-18 Merck & Co., Inc. Thiazole benzenesulfonamides as beta3 agonists for the treatment of diabetes and obesity
ATE266639T1 (de) 1997-10-17 2004-05-15 Yamanouchi Pharma Co Ltd Amidderivate oder deren salze
DE69939367D1 (de) 1998-01-12 2008-10-02 Felder Robin A G protein-verwandte kinasemutanten in der essentiellen hypertonie
AU2781899A (en) 1998-02-24 1999-09-15 Trustees Of The University Of Pennsylvania, The Use of a cardiac purinoceptor to effect cellular glucose uptake
GB9812709D0 (en) 1998-06-13 1998-08-12 Glaxo Group Ltd Chemical compounds
AR019868A1 (es) 1998-06-18 2002-03-20 Novartis Ag Uso de derivados de 2-[n-(1-hidroximetil)piperidina para la preparacion de repelentes contra insectos, garrapatas y acaros, proceso para disuadir insectosgarrapatas y acaros, composicion para repeler insectos, garrapatas y acaros, y proceso para la preparacion de dicha composicion
RU2226054C2 (ru) * 1998-06-18 2004-03-27 Новартис Аг Композиция для отпугивания паразитов
MY126489A (en) 1998-07-08 2006-10-31 Kissei Pharmaceutical Phenoxyacetic acid derivatives and medicinal compositions containing the same
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
US20030018061A1 (en) 2000-01-28 2003-01-23 Kohei Ogawa Novel remedies with the use of beta 3 agonist
US6403612B2 (en) * 2000-01-31 2002-06-11 Merck & Co., Inc. Thrombin receptor antagonists
ATE369337T1 (de) 2000-04-28 2007-08-15 Asahi Kasei Pharma Corp Neue bizyklische verbindungen
HUP0301382A2 (hu) 2000-10-20 2003-11-28 Pfizer Products Inc. Alfa-aril-etanol-amin-származékok és e vegyületeket tartalmazó béta-3 adrenergiás receptor agonista hatású gyógyászati készítmények
US20100022658A1 (en) 2000-11-01 2010-01-28 Cognition Pharmaceuticals Llc Methods for treating cognitive impairment in humans
WO2001074782A1 (en) 2001-03-29 2001-10-11 Molecular Design International, Inc. β3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME
CN1276911C (zh) 2001-09-30 2006-09-27 沈阳药科大学 具有β2－受体兴奋作用的新型苯乙醇胺类化合物及其制法
CA2463624A1 (en) 2001-10-15 2003-04-24 National Research Council Of Canada Anti-glycation agents for preventing age-, diabetes-, and smoking-related complications
AU2003232405A1 (en) 2002-06-04 2003-12-19 Pfizer Products Inc. Flourinated cyclic amides as dipeptidyl peptidase iv inhibitors
EP1540332A1 (en) 2002-07-03 2005-06-15 Duke University Methods of screening compounds for grk6 modulating activity
WO2004022566A1 (en) 2002-09-04 2004-03-18 Pharmacia & Upjohn Company Llc 4-OXO-4,7-DIHYDROTHIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS
US7550133B2 (en) 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
GB0303396D0 (en) 2003-02-14 2003-03-19 Glaxo Group Ltd Medicinal compounds
WO2004110375A2 (en) 2003-06-06 2004-12-23 Merck & Co., Inc. Combination therapy for the treatment of diabetes
AU2003904237A0 (en) 2003-08-08 2003-08-21 Garvan Institute Of Medical Research Novel translocation assay
CA2538415A1 (en) 2003-09-15 2005-03-24 Wilfred Wayne Lautt Use of antagonists of hepatic sympathetic nerve activity
JP2005097149A (ja) 2003-09-24 2005-04-14 Dainippon Pharmaceut Co Ltd ［３−［（２ｒ）−［［（２ｒ）−（３−クロロフェニル）−２−ヒドロキシエチル］アミノ］プロピル］−１ｈ−インドール−７−イルオキシ］酢酸の溶媒和物
FR2861073B1 (fr) 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
KR20060124731A (ko) 2004-01-29 2006-12-05 뉴로몰레큘라 파마슈티칼스, 인코포레이티드 중추신경계-관련 질환 치료용 ｎｍｄａ 수용체 길항제 및ｍａｏ-억제제 또는 ｇａｄｐｈ-억제제의 배합물
HUP0400405A3 (en) 2004-02-10 2009-03-30 Sanofi Synthelabo Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
DE102004019539A1 (de) 2004-04-22 2005-11-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittel zur Behandlung von Atemwegserkrankungen
US20050250944A1 (en) 2004-05-04 2005-11-10 Jian Chen Synthesis and uses of synephrine derivatives
JP2007537187A (ja) 2004-05-13 2007-12-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 呼吸器疾患の治療においてβアゴニストとして使用するためのヒドロキシ置換ベンゾ縮合ヘテロ環化合物
EP1595873A1 (de) 2004-05-13 2005-11-16 Boehringer Ingelheim Pharma GmbH & Co.KG Substituierte Cycloalkylderivate zur Behandlung von Atemswegerkrankungen
WO2005114195A1 (en) 2004-05-21 2005-12-01 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor kinase 4 (grk4)
CA2571683A1 (en) 2004-06-30 2006-01-12 Combinatorx, Incorporated Methods and reagents for the treatment of metabolic disorders
US20080064736A1 (en) * 2004-07-12 2008-03-13 Bayer Cropscience Ag Substituted 2-Pyrrolidone Derivatives as Fungicides and Insecticides
WO2006027579A2 (en) 2004-09-07 2006-03-16 Sosei R & D Ltd. The treatment of inflammatory disorders and pain
US20100173928A1 (en) 2005-01-28 2010-07-08 Sabatini David M Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
TW200740779A (en) 2005-07-22 2007-11-01 Mitsubishi Pharma Corp Intermediate compound for synthesizing pharmaceutical agent and production method thereof
ZA200801858B (en) 2005-08-29 2009-07-29 Kissei Pharmaceutical Preventive or therapeutic agent for disease caused by decrease in lacrimal fluid
JP2007217368A (ja) 2006-02-17 2007-08-30 Japan Health Science Foundation ＰＧＣ−１α発現促進剤及びＰＧＣ−１α発現抑制剤、並びにそれらの使用方法
US20090181976A1 (en) 2006-02-28 2009-07-16 Buschmann Helmut H Use of Compounds Binding to the Sigma Receptor for the Treatment of Metabolic Syndrome
EP1829534A1 (en) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Use of compounds binding to the sigma receptor for the treatment of metabolic syndrome
GB0604826D0 (en) * 2006-03-09 2006-04-19 Arakis Ltd The treatment of inflammatory disorders and pain
WO2007109882A1 (en) 2006-03-24 2007-10-04 National Research Council Of Canada Anti-diabetic cataract compounds and their uses
AU2007275301A1 (en) 2006-07-20 2008-01-24 Amgen Inc. Substituted azole aromatic heterocycles as inhibitors of 11-beta-HSD-1
AU2007286051B2 (en) 2006-08-10 2013-01-10 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Preparation of (R,R)-fenoterol and (R,R)- or (R,S)-fenoterol analogues and their use in treating congestive heart failure
GB0624757D0 (en) 2006-12-12 2007-01-17 Sosei R & D Ltd Novel compounds
FR2917735B1 (fr) * 2007-06-21 2009-09-04 Sanofi Aventis Sa Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique
PE20091825A1 (es) 2008-04-04 2009-12-04 Merck & Co Inc Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3
FR2932818B1 (fr) 2008-06-23 2015-12-04 Centre Nat Rech Scient Lignee d'adipocytes bruns humains et procede de differenciation a partir d'une lignee de cellules hmads.
WO2010016939A1 (en) 2008-08-08 2010-02-11 The Trustees Of Columbia University In The City Of New York Hypoglycemic dihydropyridones
US8637524B2 (en) 2009-07-28 2014-01-28 Auspex Pharmaceuticals, Inc Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2
US20110055367A1 (en) 2009-08-28 2011-03-03 Dollar James E Serial port forwarding over secure shell for secure remote management of networked devices
US8735604B2 (en) 2009-09-22 2014-05-27 Merck Sharp & Dohme Corp. Pyrrolidines as glucagon receptor antagonists, compositions, and methods for their use
WO2011112867A1 (en) 2010-03-10 2011-09-15 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
EP2426202A1 (en) 2010-09-03 2012-03-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Kinases as targets for anti-diabetic therapy
US20120122843A1 (en) 2010-11-11 2012-05-17 Astrazeneca Ab Compounds and Their Use for Treatment of Amyloid Beta-Related Diseases
US9034839B2 (en) 2012-04-20 2015-05-19 Aptamir Therapeutics, Inc. miRNA modulators of thermogenesis
WO2014108449A1 (en) 2013-01-08 2014-07-17 Atrogi Ab A screening method, a kit, a method of treatment and a compound for use in a method of treatment
US9657348B2 (en) 2013-01-13 2017-05-23 Atrogi Ab Method of screening compounds for the treatment of diabetes
CN103565784A (zh) 2013-11-04 2014-02-12 匡仲平 一种减肥药剂
US9891212B2 (en) 2013-12-16 2018-02-13 Atrogi Ab Screening method, a kit, a method of treatment and a compound for use in a method of treatment
WO2016004995A1 (en) 2014-07-09 2016-01-14 Atrogi Ab A method of screening for a compound capable of stimulating glucose transport into brown and/or brite adipocytes of a mammal, a kit for use in such a method
CN105078946A (zh) 2015-08-07 2015-11-25 重庆理工大学 沙美特罗在治疗二型糖尿病、胰岛素抵抗药物上的应用
US20190119196A1 (en) * 2016-03-07 2019-04-25 Atrogi Ab Compounds for the treatment of hyperglycaemia
CN106083837B (zh) 2016-05-27 2018-08-31 浙江普洛得邦制药有限公司 一种噁唑烷酮类抗菌药物及其中间体的制备方法
GB201612165D0 (en) 2016-07-13 2016-08-24 Atrogi Ab Combinations for the treatment of type 2 diabetes
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201903827D0 (en) 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods

Also Published As

Publication number Publication date
GB201714740D0 (en) 2017-10-25
EP3681862C0 (en) 2023-11-08
CN111164072A (zh) 2020-05-15
RU2020108488A (ru) 2021-10-15
BR112020005064A2 (pt) 2020-09-15
EP3681862B1 (en) 2023-11-08
IL273171A (en) 2020-04-30
EP3681862A1 (en) 2020-07-22
WO2019053425A1 (en) 2019-03-21
JP7346388B2 (ja) 2023-09-19
AU2018332145A1 (en) 2020-04-16
CA3075705A1 (en) 2019-03-21
RU2020108488A3 (enExample) 2022-03-25
US20200277259A1 (en) 2020-09-03
MX2020002824A (es) 2020-09-14
US11427539B2 (en) 2022-08-30
JP2020534264A (ja) 2020-11-26

Similar Documents

Publication Publication Date Title
KR20200051776A (ko) 베타-히드록시 헤테로사이클릭 아민 및 과혈당증의 치료에서의 이의 용도
JP7046842B2 (ja) 高血糖症の治療のための化合物
KR102849497B1 (ko) 플루오로페닐 베타-히드록시에틸아민 및 과혈당증의 치료에서의 이의 용도
KR20200052936A (ko) 과혈당증의 치료에 사용하기 위한 헤테로아릴 치환된 베타-히드록시에틸아민
WO2020188301A1 (en) Heterocyclyl(phenyl)methanol compounds useful in the treatment of hyperglycaemia
US12378216B2 (en) Heteroaryl(heterocyclyl)methanol compounds useful in the treatment of hyperglycaemia
US11793774B2 (en) Chiral beta-hydroxyethylamines and their use in the treatment of hyperglycemia
WO2022063895A1 (en) Arylazabicyclo[2.1.1]hexylmethanol derivatives and medical uses thereof
EP4405333A1 (en) Substituted hydroxymethyl pyrrolidines and medical uses thereof
WO2024200777A1 (en) Substituted hydroxymethyl pyrrolidines for use in the treatment of hyperglycaemia and disorders characterised by hyperglycaemia
KR20250161027A (ko) 과혈당증 및 과혈당증을 특징으로 하는 장애의 치료에 사용하기 위한 헤테로사이클로알킬 베타-하이드록시 알킬 아민

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20200410

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20210903

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20231114

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20240124

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20231114

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I