RU2020108488A - Бета-гидрокси-гетероциклические амины и их применение для лечения гипергликемии - Google Patents

Бета-гидрокси-гетероциклические амины и их применение для лечения гипергликемии Download PDF

Info

Publication number
RU2020108488A
RU2020108488A RU2020108488A RU2020108488A RU2020108488A RU 2020108488 A RU2020108488 A RU 2020108488A RU 2020108488 A RU2020108488 A RU 2020108488A RU 2020108488 A RU2020108488 A RU 2020108488A RU 2020108488 A RU2020108488 A RU 2020108488A
Authority
RU
Russia
Prior art keywords
independently
compound
paragraphs
compound according
optionally substituted
Prior art date
Application number
RU2020108488A
Other languages
English (en)
Russian (ru)
Other versions
RU2020108488A3 (enExample
Inventor
Бенджамин ПЕЛЬЦМАН
Торе БЕНГТССОН
Original Assignee
Атроги Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Атроги Аб filed Critical Атроги Аб
Publication of RU2020108488A publication Critical patent/RU2020108488A/ru
Publication of RU2020108488A3 publication Critical patent/RU2020108488A3/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
RU2020108488A 2017-09-13 2018-09-13 Бета-гидрокси-гетероциклические амины и их применение для лечения гипергликемии RU2020108488A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1714740.6 2017-09-13
GBGB1714740.6A GB201714740D0 (en) 2017-09-13 2017-09-13 New compounds and uses
PCT/GB2018/052593 WO2019053425A1 (en) 2017-09-13 2018-09-13 BETA-HYDROXY HETEROCYCLIC AMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCEMIA

Publications (2)

Publication Number Publication Date
RU2020108488A true RU2020108488A (ru) 2021-10-15
RU2020108488A3 RU2020108488A3 (enExample) 2022-03-25

Family

ID=60117153

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2020108488A RU2020108488A (ru) 2017-09-13 2018-09-13 Бета-гидрокси-гетероциклические амины и их применение для лечения гипергликемии

Country Status (13)

Country Link
US (1) US11427539B2 (enExample)
EP (1) EP3681862B1 (enExample)
JP (1) JP7346388B2 (enExample)
KR (1) KR20200051776A (enExample)
CN (1) CN111164072A (enExample)
AU (1) AU2018332145A1 (enExample)
BR (1) BR112020005064A2 (enExample)
CA (1) CA3075705A1 (enExample)
GB (1) GB201714740D0 (enExample)
IL (1) IL273171A (enExample)
MX (1) MX2020002824A (enExample)
RU (1) RU2020108488A (enExample)
WO (1) WO2019053425A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201903827D0 (en) * 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods
GB201903832D0 (en) 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods
GB202015035D0 (en) * 2020-09-23 2020-11-04 Atrogi Ab New compounds and methods
GB202015044D0 (en) * 2020-09-23 2020-11-04 Atrogi Ab New compounds and methods
WO2022109179A1 (en) * 2020-11-19 2022-05-27 Curasen Therapeutics, Inc. Beta adrenergic agonist and methods of using the same
GB202304604D0 (en) * 2023-03-29 2023-05-10 Atrogi Ab New compounds and medical uses thereof
KR20250161027A (ko) * 2023-03-29 2025-11-14 아트로기 에이비 과혈당증 및 과혈당증을 특징으로 하는 장애의 치료에 사용하기 위한 헤테로사이클로알킬 베타-하이드록시 알킬 아민

Family Cites Families (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE45721C (enExample)
DE638650C (de) 1934-06-08 1936-11-20 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von 3, 4-Dioxyphenylmonoalkylaminobutanolen-1
US2308232A (en) 1939-01-17 1943-01-12 Scheuing Georg Isopropylaminomethyl-(3, 4-dioxyphenyl) carbinol
US2460144A (en) 1946-04-11 1949-01-25 Sterling Drug Inc Hydroxyphenyl alkanolamines
FR1165845A (fr) 1955-05-28 1958-10-29 Philips Nv Amines secondaires portant des substituants et leur préparation
FR1324914A (fr) 1961-01-11 1963-04-26 Philips Nv Procédé de préparation d'aralkylamines substituées optiquement actives
DE1275069B (de) 1960-02-15 1968-08-14 Boehringer Sohn Ingelheim 1-(3', 5'-Dihydroxyphenyl)-1-hydroxy-2-isopropylaminoalkane und Verfahren zu ihrer Herstellung
NL6401871A (enExample) 1964-02-27 1965-08-30
SE335359B (enExample) 1966-10-19 1971-05-24 Draco Ab
AT285583B (de) 1968-10-10 1970-11-10 Chemie Linz Ag Verfahren zur Herstellung von N,N'-bis-[2-(3',4'-Dihydroxyphenyl)-2-hydroxyäthyl]-hexamethylendiamin und seinen Salzen
GB1298771A (en) 1969-04-01 1972-12-06 Sterling Drug Inc Carboxylic esters of hydroxyphenylalkanolamines
GB1321701A (en) 1969-10-01 1973-06-27 Continental Pharma Amino-alcohols their salts and process for prepairing the same
US3910934A (en) 1970-05-21 1975-10-07 Minnesota Mining & Mfg Process for the preparation of {60 -(hydroxy and alkoxy substituted)phenyl-{60 -(2-piperidinyl)-methanols
GB1298494A (en) 1970-06-17 1972-12-06 Allen & Hanburys Ltd Phenylethanolamine derivatives
DE2157040A1 (de) 1971-11-17 1973-05-24 Thomae Gmbh Dr K Neues verfahren zur herstellung von 4-amino-3,5-dihalogen-phenyl-aethanolaminen
US3801631A (en) 1972-02-16 1974-04-02 Mead Johnson & Co 2'-hydroxy-5'-(1-hydroxy-2-(2-methyl-1-phenyl-2-propylamino)ethyl)meth-anesulfonanilide and its salts
DE2300614A1 (de) 1973-01-08 1974-07-18 Thomae Gmbh Dr K Neue optisch aktive verbindungen
DE2259282A1 (de) 1972-12-04 1974-06-12 Thomae Gmbh Dr K Neue aminoaethanole
US4119710A (en) 1972-12-18 1978-10-10 Boehringer Ingelheim Gmbh Bronchospasmolytic 1-(p-amino-phenyl)-2-amino-ethanols-(1) and salts
US3985887A (en) * 1973-10-19 1976-10-12 Smithkline Corporation 3-Substituted-4-hydroxyphenyl-2-piperidylcarbinols as β-adrenergic stimulants
US3910933A (en) * 1973-10-19 1975-10-07 Smithkline Corp 3-Substituted-4-hydroxyphenyl-2-piperidylcarbinols
JPS539227B2 (enExample) 1973-12-26 1978-04-04
DE2413102C3 (de) 1974-03-19 1980-09-11 C.H. Boehringer Sohn, 6507 Ingelheim Verfahren zur Herstellung von l-(3,5-Dihydroxyphenyl)-t-hydroxy-2- eckige Klammer auf 1-methyl-2-(4-hydroxyphenyl)- äthyl] -aminoäthan
CA1030146A (en) 1974-04-18 1978-04-25 American Home Products Corporation Thiophene ethanolamines
FR2289185A1 (fr) 1974-10-30 1976-05-28 Scherico Ltd Composes azacycliques
US3952101A (en) 1975-04-14 1976-04-20 Smithkline Corporation α-Amino methyl-5-hydroxy-2-pyridinemethanols
CH624395A5 (enExample) 1976-01-08 1981-07-31 Ciba Geigy Ag
JPS6048503B2 (ja) 1976-02-27 1985-10-28 興和株式会社 新規な1−フエニル−2−アミノエタノ−ル誘導体
JPS609713B2 (ja) 1976-10-08 1985-03-12 大塚製薬株式会社 カルボスチリル誘導体
AR214005A1 (es) 1977-05-02 1979-04-11 Pfizer Procedimiento para preparar 2-hidroximetil-3-hidroxi-6-(1-hidroxi-2-t-butilaminoetil)piridina
NZ187066A (en) 1977-05-03 1981-02-11 Hoffmann La Roche 4-(3-substitutedamino-2-hydroxypropoxy)-benzimidazolidin-2-(ones or thiones)
DE2838923A1 (de) 1978-09-07 1980-04-03 Thomae Gmbh Dr K Verwendung von phenylaethanolaminen als antiphlogistica
FR2436779A1 (fr) * 1978-09-22 1980-04-18 Pharmindustrie Derives de pyrrolidine-2 methanol utilisables comme medicaments
EP0023385B1 (en) 1979-06-16 1982-12-15 Beecham Group Plc Ethanamine derivatives, their preparation and use in pharmaceutical compositions
FR2460929A1 (fr) 1979-07-06 1981-01-30 Roussel Uclaf Nouveaux derives de l'a-phenyl 2-pyrrolidinemethanol et leur sels, procede de preparation, application a titre de medicaments et compositions les renfermant
JPS5655355A (en) 1979-10-15 1981-05-15 Paamakemu Asia:Kk Preparation of alkylenediamine derivative
FR2486074A1 (fr) 1979-12-14 1982-01-08 Lafon Labor Derives de fluorophenacyl-amine, leur procede de preparation et leur application en therapeutique
EP0043807B1 (en) 1980-07-09 1984-05-30 Aktiebolaget Draco 1-(dihydroxyphenyl)-2-amino-ethanol derivatives; preparation, compositions and intermediates
EP0117647B1 (en) 1983-01-31 1988-08-17 Eli Lilly And Company Improvements in or relating to phenethanolamines
EP0128120A3 (de) 1983-06-02 1985-11-13 Ciba-Geigy Ag Trisubstituierte Oxazolidinone
ES524680A0 (es) 1983-08-02 1984-12-16 Espanola Farma Therapeut Procedimiento de obtencion de nuevos compuestos derivados de la difenil-metilen-etilamina.
CA1249992A (en) 1983-11-10 1989-02-14 Marcel Muller Oxazolidines
GB2151612B (en) 1983-11-25 1988-08-03 Lafon Labor The use of the family of 2-amino-1-(methoxyphenyl)-1- ethanol derivatives for the manufacture of a medicament for use as a vasodilating agent
US4614746A (en) 1985-03-21 1986-09-30 American Cyanamid Company 5-fluorobenzonitrile derivatives for increasing the lean meat to fat ratio and/or enhancing the growth rate of warm-blooded animals
DE3615293A1 (de) 1986-05-06 1987-11-12 Bayer Ag Verwendung von heteroarylethylaminen zur leistungsfoerderung bei tieren, heteroarylethylamine und verfahren zu ihrer herstellung
GB8714901D0 (en) 1986-07-23 1987-07-29 Ici Plc Amide derivatives
HU203667B (en) 1986-12-11 1991-09-30 Roussel Uclaf Process for producing synergetic zootechnical compositions containing three components
AU598644B2 (en) 1987-03-10 1990-06-28 Beecham Group Plc Compounds and treatment
DE3852589T2 (de) 1987-08-12 1995-08-10 Sanofi Sa Verfahren zur O-Alkylierung von N-(Hydroxy)aralkylphenylethanolamin.
US5019578A (en) 1987-11-27 1991-05-28 Merck & Co., Inc. β-adrenergic agonists
FR2647310B1 (fr) 1989-05-29 1992-01-17 Roussel Uclaf Utilisation de beta-adrenergiques pour la fabrication de compositions zootechniques
IE65511B1 (en) 1989-12-29 1995-11-01 Sanofi Sa New phenylethanolaminomethyltetralins
AU7174191A (en) 1990-01-05 1991-07-24 Sepracor, Inc. Optically pure r(-) albuterol for treating asthma
US5061727A (en) 1990-05-04 1991-10-29 American Cyanamid Company Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles
GB9107196D0 (en) 1991-04-05 1991-05-22 Sandoz Ag Improvements in or relating to organic compounds
NO179246C (no) 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
IL104567A (en) 1992-02-03 1997-03-18 Fujisawa Pharmaceutical Co Ethanolamine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US5451677A (en) 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
US5776983A (en) 1993-12-21 1998-07-07 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
US5705515A (en) 1994-04-26 1998-01-06 Merck & Co., Inc. Substituted sulfonamides as selective β-3 agonists for the treatment of diabetes and obesity
US5726165A (en) 1994-07-29 1998-03-10 Smithkline Beecham P.L.C. Derivatives of 4-(2-aminoethyl)phenoxymethyl-phosphonic and -phosphinic acid and pharmaceutical and veterinary uses therefor
US5541204A (en) 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
CA2242351C (en) 1996-01-10 2003-03-11 Asahi Kasei Kogyo Kabushiki Kaisha Novel tricyclic compounds and drug compositions containing the same
WO1998022480A1 (en) 1996-11-18 1998-05-28 Smithkline Beecham Plc Phosphorus containing aryloxy or arylthio propanolamine derivatives
HUP0002053A3 (en) 1997-01-28 2001-09-28 Merck & Co Inc Thiazole benzenesulfonamides as beta3 agonists for the treatment of diabetes and obesity
AR017340A1 (es) 1997-10-17 2001-09-05 Astellas Pharma Inc Un derivado de amida, su uso y una composicion farmaceutica que lo comprende.
DE69939367D1 (de) 1998-01-12 2008-10-02 Felder Robin A G protein-verwandte kinasemutanten in der essentiellen hypertonie
WO1999043326A1 (en) 1998-02-24 1999-09-02 The Trustees Of The University Of Pennsylvania Use of a cardiac purinoceptor to effect cellular glucose uptake
GB9812709D0 (en) 1998-06-13 1998-08-12 Glaxo Group Ltd Chemical compounds
PT1087660E (pt) * 1998-06-18 2002-11-29 Novartis Ag Formulacoes para repelir vermina
DK1087662T3 (da) * 1998-06-18 2002-07-29 Novartis Ag Middel til at afskrække skadedyr
MY126489A (en) 1998-07-08 2006-10-31 Kissei Pharmaceutical Phenoxyacetic acid derivatives and medicinal compositions containing the same
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
US20030018061A1 (en) 2000-01-28 2003-01-23 Kohei Ogawa Novel remedies with the use of beta 3 agonist
US6403612B2 (en) * 2000-01-31 2002-06-11 Merck & Co., Inc. Thrombin receptor antagonists
KR100502876B1 (ko) 2000-04-28 2005-07-21 아사히 가세이 파마 가부시키가이샤 신규 이환성 화합물
AU2001292161A1 (en) 2000-10-20 2002-04-29 Pfizer Products Inc. Alpha-aryl ethanolamines and their use as beta-3 adrenergic receptor agonists
US20100022658A1 (en) 2000-11-01 2010-01-28 Cognition Pharmaceuticals Llc Methods for treating cognitive impairment in humans
AU782148B2 (en) 2001-03-29 2005-07-07 Molecular Design International, Inc. Beta3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
CN1276911C (zh) 2001-09-30 2006-09-27 沈阳药科大学 具有β2-受体兴奋作用的新型苯乙醇胺类化合物及其制法
WO2003032969A2 (en) 2001-10-15 2003-04-24 National Research Council Of Canada Anti-glycation agents for preventing age-, diabetes-, and smoking-related complications
WO2003101958A2 (en) 2002-06-04 2003-12-11 Pfizer Products Inc. Flourinated cyclic amides as dipeptidyl peptidase iv inhibitors
JP2005535317A (ja) 2002-07-03 2005-11-24 デューク ユニヴァーシティー Grk6調節活性について化合物をスクリーニングする方法
WO2004022566A1 (en) 2002-09-04 2004-03-18 Pharmacia & Upjohn Company Llc 4-OXO-4,7-DIHYDROTHIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS
US7550133B2 (en) 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
GB0303396D0 (en) 2003-02-14 2003-03-19 Glaxo Group Ltd Medicinal compounds
US20070099884A1 (en) 2003-06-06 2007-05-03 Erondu Ngozi E Combination therapy for the treatment of diabetes
AU2003904237A0 (en) 2003-08-08 2003-08-21 Garvan Institute Of Medical Research Novel translocation assay
CA2538415A1 (en) 2003-09-15 2005-03-24 Wilfred Wayne Lautt Use of antagonists of hepatic sympathetic nerve activity
JP2005097149A (ja) 2003-09-24 2005-04-14 Dainippon Pharmaceut Co Ltd [3−[(2r)−[[(2r)−(3−クロロフェニル)−2−ヒドロキシエチル]アミノ]プロピル]−1h−インドール−7−イルオキシ]酢酸の溶媒和物
FR2861073B1 (fr) 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
CA2554959A1 (en) 2004-01-29 2005-08-11 Neuromolecular, Inc. Combination of a nmda receptor antagonist and a mao-inhibitor or a gadpf-inhibitor for the treatment of central nervous system-related conditions
HUP0400405A3 (en) 2004-02-10 2009-03-30 Sanofi Synthelabo Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
DE102004019539A1 (de) 2004-04-22 2005-11-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittel zur Behandlung von Atemwegserkrankungen
US20050250944A1 (en) 2004-05-04 2005-11-10 Jian Chen Synthesis and uses of synephrine derivatives
EP1595873A1 (de) 2004-05-13 2005-11-16 Boehringer Ingelheim Pharma GmbH & Co.KG Substituierte Cycloalkylderivate zur Behandlung von Atemswegerkrankungen
EP1789394A1 (de) 2004-05-13 2007-05-30 Boehringer Ingelheim International Gmbh Hydroxy-substituierte benzkondensierte heterozyklen als betaagonisten zur behandlung von atemwegserkrankungen
WO2005114195A1 (en) 2004-05-21 2005-12-01 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor kinase 4 (grk4)
BRPI0512856A (pt) 2004-06-30 2008-04-08 Combinatorx Inc métodos e reagentes para o tratamento de distúrbios metabólicos
US20080064736A1 (en) * 2004-07-12 2008-03-13 Bayer Cropscience Ag Substituted 2-Pyrrolidone Derivatives as Fungicides and Insecticides
EP1786410A2 (en) 2004-09-07 2007-05-23 Sosei R&D Ltd. The treatment of inflammatory disorders and pain
US20100173928A1 (en) 2005-01-28 2010-07-08 Sabatini David M Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
TW200740779A (en) 2005-07-22 2007-11-01 Mitsubishi Pharma Corp Intermediate compound for synthesizing pharmaceutical agent and production method thereof
WO2007026630A1 (ja) 2005-08-29 2007-03-08 Kissei Pharmaceutical Co., Ltd. 涙液の減少に伴う疾患の予防又は治療剤
JP2007217368A (ja) 2006-02-17 2007-08-30 Japan Health Science Foundation PGC−1α発現促進剤及びPGC−1α発現抑制剤、並びにそれらの使用方法
EP1829534A1 (en) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Use of compounds binding to the sigma receptor for the treatment of metabolic syndrome
EP1991211A1 (en) 2006-02-28 2008-11-19 Laboratorios Del Dr. Esteve, S.A. Use of compounds binding to the sigma receptor for the treatment of metabolic syndrome
GB0604826D0 (en) * 2006-03-09 2006-04-19 Arakis Ltd The treatment of inflammatory disorders and pain
WO2007109882A1 (en) 2006-03-24 2007-10-04 National Research Council Of Canada Anti-diabetic cataract compounds and their uses
AU2007275301A1 (en) 2006-07-20 2008-01-24 Amgen Inc. Substituted azole aromatic heterocycles as inhibitors of 11-beta-HSD-1
CN103739503A (zh) 2006-08-10 2014-04-23 美国政府健康及人类服务部 (r,r)-非诺特罗和(r,r)-或(r,s)-非诺特罗类似物的制备及其在治疗充血性心力衰竭中的应用
GB0624757D0 (en) 2006-12-12 2007-01-17 Sosei R & D Ltd Novel compounds
FR2917735B1 (fr) * 2007-06-21 2009-09-04 Sanofi Aventis Sa Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique
PE20091825A1 (es) 2008-04-04 2009-12-04 Merck & Co Inc Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3
FR2932818B1 (fr) 2008-06-23 2015-12-04 Centre Nat Rech Scient Lignee d'adipocytes bruns humains et procede de differenciation a partir d'une lignee de cellules hmads.
WO2010016939A1 (en) 2008-08-08 2010-02-11 The Trustees Of Columbia University In The City Of New York Hypoglycemic dihydropyridones
US8637524B2 (en) 2009-07-28 2014-01-28 Auspex Pharmaceuticals, Inc Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2
US20110055367A1 (en) 2009-08-28 2011-03-03 Dollar James E Serial port forwarding over secure shell for secure remote management of networked devices
EP2480077B1 (en) 2009-09-22 2015-02-18 Merck Sharp & Dohme Corp. Pyrrolidines as glucagon receptor antagonists, compositions, and methods for their use
US9492405B2 (en) 2010-03-10 2016-11-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
EP2426202A1 (en) 2010-09-03 2012-03-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Kinases as targets for anti-diabetic therapy
US20120122843A1 (en) 2010-11-11 2012-05-17 Astrazeneca Ab Compounds and Their Use for Treatment of Amyloid Beta-Related Diseases
US9034839B2 (en) 2012-04-20 2015-05-19 Aptamir Therapeutics, Inc. miRNA modulators of thermogenesis
US9784726B2 (en) 2013-01-08 2017-10-10 Atrogi Ab Screening method, a kit, a method of treatment and a compound for use in a method of treatment
WO2014108531A1 (en) 2013-01-13 2014-07-17 Atrogi Ab A screening method, a kit, a method of treatment and a compound for use in a method of treatment
CN103565784A (zh) 2013-11-04 2014-02-12 匡仲平 一种减肥药剂
US9891212B2 (en) 2013-12-16 2018-02-13 Atrogi Ab Screening method, a kit, a method of treatment and a compound for use in a method of treatment
WO2016004995A1 (en) 2014-07-09 2016-01-14 Atrogi Ab A method of screening for a compound capable of stimulating glucose transport into brown and/or brite adipocytes of a mammal, a kit for use in such a method
CN105078946A (zh) 2015-08-07 2015-11-25 重庆理工大学 沙美特罗在治疗二型糖尿病、胰岛素抵抗药物上的应用
KR20180117696A (ko) * 2016-03-07 2018-10-29 아트로기 에이비 과혈당증의 치료를 위한 화합물
CN106083837B (zh) 2016-05-27 2018-08-31 浙江普洛得邦制药有限公司 一种噁唑烷酮类抗菌药物及其中间体的制备方法
GB201612165D0 (en) 2016-07-13 2016-08-24 Atrogi Ab Combinations for the treatment of type 2 diabetes
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201903827D0 (en) 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods

Also Published As

Publication number Publication date
JP2020534264A (ja) 2020-11-26
US20200277259A1 (en) 2020-09-03
AU2018332145A1 (en) 2020-04-16
JP7346388B2 (ja) 2023-09-19
EP3681862B1 (en) 2023-11-08
IL273171A (en) 2020-04-30
GB201714740D0 (en) 2017-10-25
RU2020108488A3 (enExample) 2022-03-25
WO2019053425A1 (en) 2019-03-21
US11427539B2 (en) 2022-08-30
BR112020005064A2 (pt) 2020-09-15
CA3075705A1 (en) 2019-03-21
CN111164072A (zh) 2020-05-15
EP3681862A1 (en) 2020-07-22
KR20200051776A (ko) 2020-05-13
EP3681862C0 (en) 2023-11-08
MX2020002824A (es) 2020-09-14

Similar Documents

Publication Publication Date Title
RU2020108488A (ru) Бета-гидрокси-гетероциклические амины и их применение для лечения гипергликемии
JP2020533352A5 (enExample)
JP2020534264A5 (enExample)
RU2020108523A (ru) Гетероарил-замещенные бета-гидроксиэтиламины для применения для лечения гипергликемии
RU2015143610A (ru) Лечение катаплексии
JP2016518437A5 (enExample)
JP2011527334A5 (enExample)
JP2004507465A5 (enExample)
JPWO2022177917A5 (enExample)
RU2010126056A (ru) Органические соединения
JP2017531689A5 (enExample)
JP2019510082A5 (enExample)
JP2020143129A5 (enExample)
RU2016122731A (ru) Функционализированные и замещенные индолы в качестве противораковых агентов
JP2008534453A5 (enExample)
JP2016505071A5 (enExample)
JP2020534266A5 (enExample)
RU2007101653A (ru) Производные 1-азабицикло[3.3.1]нонанов
JP2020111571A5 (enExample)
JP2013522368A5 (enExample)
RU2016112053A (ru) Композиции для лечения гипертензии и/или фиброза
RU2002101622A (ru) Нафтохиноновые производные и их использование для лечения и борьбы с туберкулезом
RU2013112003A (ru) Противоопухолевые соединения
RU2008112181A (ru) Применение конденсированных производных имидазола для лечения заболеваний, опосредованных рецептором ccr3
RU2013113301A (ru) Замещенные 2-оксо- и 2-тиоксо-дигидрохинолин-3-карбоксамиды в качестве модуляторов kcnq2/3