KR20200004784A - 효모에서 파이토카나비노이드 및 파이토카나비노이드 유사체를 제조하기 위한 세포주 및 방법 - Google Patents

효모에서 파이토카나비노이드 및 파이토카나비노이드 유사체를 제조하기 위한 세포주 및 방법 Download PDF

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KR20200004784A
KR20200004784A KR1020197027008A KR20197027008A KR20200004784A KR 20200004784 A KR20200004784 A KR 20200004784A KR 1020197027008 A KR1020197027008 A KR 1020197027008A KR 20197027008 A KR20197027008 A KR 20197027008A KR 20200004784 A KR20200004784 A KR 20200004784A
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phytocanabinoid
ala
leu
val
gly
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쇼햄 무커지
알렉산더 제임스 캠벨
재커리 더글라스 윌트셔
케빈 존 첸
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히야신스 바이오로지컬스 아이엔씨.
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KR1020197027008A 2017-02-17 2018-02-19 효모에서 파이토카나비노이드 및 파이토카나비노이드 유사체를 제조하기 위한 세포주 및 방법 Withdrawn KR20200004784A (ko)

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US201762460526P 2017-02-17 2017-02-17
US62/460,526 2017-02-17
PCT/CA2018/050189 WO2018148848A1 (en) 2017-02-17 2018-02-19 Method and cell line for production of phytocannabinoids and phytocannabinoid analogues in yeast

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KR1020197027012A Active KR102589523B1 (ko) 2017-02-17 2018-02-19 효모에서 폴리케티드를 제조하기 위한 세포주 및 방법

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AU (2) AU2018220470B2 (https=)
CA (2) CA3054423A1 (https=)
IL (2) IL268725B2 (https=)
MX (2) MX2019009708A (https=)
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Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110914416B (zh) 2017-04-27 2023-07-21 加州大学董事会 产生大麻素和大麻素衍生物的微生物和方法
AU2018346434A1 (en) * 2017-10-05 2020-05-14 Intrexon Corporation Microorganisms and methods for the fermentation of cannabinoids
WO2019190945A1 (en) * 2018-03-29 2019-10-03 William Marsh Rice University Biosynthesis of olivetolic acid
AU2019262112A1 (en) 2018-04-30 2020-11-19 Algae-C Inc. Engineered microorganism for the production of cannabinoid biosynthetic pathway products
WO2020060948A1 (en) 2018-09-17 2020-03-26 Levadura Biotechnology, Inc. Production of cannabinoids in yeast using a fatty acid feedstock
IL326299A (en) * 2018-10-31 2026-04-01 Baymedica Inc Cannabinoid analogs and methods for their preparation
CN113227353A (zh) * 2018-11-14 2021-08-06 马努斯生物合成股份有限公司 用于产生大麻素的微生物细胞及方法
MY205459A (en) * 2018-12-06 2024-10-22 Cytomx Therapeutics Inc Matrix metalloprotease-cleavable and serine or cysteine protease-cleavable substrates and methods of use thereof
US20220127649A1 (en) * 2019-01-30 2022-04-28 Genomatica, Inc. Engineered cells for improved production of cannabinoids
EP3917642A4 (en) 2019-01-30 2023-04-05 Genomatica, Inc. RECOVERY, DECARBOXYLATION AND PURIFICATION OF CANNABINOIDS FROM GMO CULTURES
CA3130763A1 (en) 2019-02-25 2020-09-03 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
US20220186267A1 (en) * 2019-03-27 2022-06-16 Rynetech Bio, Inc. Biosynthetic Cannabidiol Production In Engineered Microorganisms
SG11202112690YA (en) * 2019-05-22 2021-12-30 Hyasynth Biologicals Inc Methods and cells for production of phytocannabinoids and phytocannabinoid precursors
ES3037766T3 (en) 2019-06-11 2025-10-07 Symrise Ag Synthesis and purification of cannabigerol and its application
CA3151799A1 (en) * 2019-08-18 2021-02-25 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
EP4025705A4 (en) * 2019-09-06 2024-01-17 Genomatica, Inc. PRENYL TRANSFERASE VARIANTS AND METHOD FOR PRODUCING PRENYLATED AROMATIC COMPOUNDS
CN120555521A (zh) * 2019-10-01 2025-08-29 杭州恩和生物科技有限公司 用于大麻素合成的酶和制备大麻素的方法
US20240084337A1 (en) * 2019-10-11 2024-03-14 National University Of Singapore Biosynthesis of cannabinoid precursors using novel aromatic prenyl transferases
KR20220079578A (ko) 2019-10-11 2022-06-13 내셔널 유니버시티 오브 싱가포르 신규 칸나비노이드 신타아제를 사용한 칸나비게롤산으로부터 칸나비노이드의 생합성
MX2022008463A (es) 2020-01-10 2022-10-18 Univ California Plataforma biosintética para la producción de ácido olivetólico y análogos del ácido olivetólico.
US20250346871A1 (en) * 2020-03-06 2025-11-13 Cellibre, Inc. Prenyltransferases and methods of making and use thereof
EP4126916A2 (en) 2020-03-27 2023-02-08 Willow Biosciences Inc. Compositions and methods for recombinant biosynthesis of cannabinoids
US12529077B2 (en) * 2020-04-08 2026-01-20 Københavns Universitet Production of geranyl diphosphate-derived compounds
EP3901256A1 (en) * 2020-04-21 2021-10-27 Synbionik GmbH Optimized production of cbga from olivetol acid and geranyl pyrophosphate via synnphb
CA3175683A1 (en) 2020-04-29 2021-11-04 Xueyang FENG Compositions and methods for enhancing recombinant biosynthesis of cannabinoids
WO2021225952A1 (en) * 2020-05-08 2021-11-11 Lygos, Inc. Large scale production of olivetol, olivetolic acid and other alkyl resorcinols by fermentation
EP4176054A1 (en) * 2020-07-03 2023-05-10 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. -Hans-Knöll-Institut- (HKI) Method for producing olivetolic acid in an amoebozoa host species
KR20230042073A (ko) * 2020-07-24 2023-03-27 히야신스 바이오로지컬스 아이엔씨. 치환된 칸나비노이드 및 전구체를 제조하기 위해 변형 효소를 이용하는 방법 및 이를 함유하는 세포
CN111979134B (zh) 2020-08-28 2022-02-15 江南大学 一种合成胭脂红酸的重组酿酒酵母的构建及其应用
CN112042677B (zh) * 2020-09-21 2021-09-14 中国农业科学院麻类研究所 一种大麻叶提取物及其制备方法、用途
US11427840B2 (en) 2020-11-20 2022-08-30 Hyasynth Biologicals Inc. Olivetolic acid cyclase variants with improved activity for use in production of phytocannabinoids
CA3199891A1 (en) * 2020-11-24 2022-06-02 Ruth Gallily Cannabinoid derivatives and their use for the treatment of inflammation and/or pain and/or obesity
US20240026314A1 (en) * 2020-11-25 2024-01-25 Steven Rothstein Polypeptides for use in the synthesis of bioactive phenolic compounds
WO2022125960A1 (en) 2020-12-11 2022-06-16 Willow Biosciences, Inc. Recombinant acyl activating enzyme (aae) genes for enhanced biosynthesis of cannabinoids and cannabinoid precursors
EP4347800A1 (en) 2021-05-26 2024-04-10 Invizyne Technologies, Inc. Prenyltransferase variants with increased thermostability
WO2023010083A2 (en) 2021-07-30 2023-02-02 Willow Biosciences, Inc. Recombinant prenyltransferase polypeptides engineered for enhanced biosynthesis of cannabinoids
CA3227236A1 (en) 2021-08-19 2023-02-23 Trish Choudhary Recombinant olivetolic acid cyclase polypeptides engineered for enhanced biosynthesis of cannabinoids
CN113881584B (zh) * 2021-09-16 2023-06-27 广东省科学院微生物研究所(广东省微生物分析检测中心) 一株经航天育种技术选育的酿酒酵母及其突变位点应用
WO2023056350A1 (en) * 2021-09-29 2023-04-06 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
WO2023069921A1 (en) 2021-10-19 2023-04-27 Epimeron Usa, Inc. Recombinant thca synthase polypeptides engineered for enhanced biosynthesis of cannabinoids
CN114621982B (zh) * 2022-03-16 2023-11-07 嘉兴欣贝莱生物科技有限公司 香叶基二磷酸酯的生物合成方法及其在制备大麻类化合物中的应用
CN116024111B (zh) * 2022-12-03 2025-09-05 中国科学院深圳先进技术研究院 一种产大麻萜酚的微生物细胞及其构建方法与应用
CN119685467A (zh) * 2023-12-01 2025-03-25 上海市东方医院(同济大学附属东方医院) 诊断和治疗阿尔茨海默病的医药制剂
CN119753053A (zh) * 2025-03-07 2025-04-04 中国农业科学院植物保护研究所 磷酸泛酰巯基乙胺基转移酶3x32、其编码基因、含有该基因的重组载体和重组菌的应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE455785T1 (de) 2000-11-02 2010-02-15 Ajinomoto Kk Neue pyrazolderivate und diese enthaltende mittel gegen diabetes
US7238514B2 (en) 2001-01-05 2007-07-03 William Marsh Rice University Diterpene-producing unicellular organism
EP1338608A3 (en) * 2001-12-20 2004-05-06 Cellzome Ag Protein complexes and methods for their use
AU2002367554A1 (en) 2001-12-20 2003-09-09 Cellzome Ag Protein complexes and methods for their use
US7186519B2 (en) 2002-11-13 2007-03-06 Trustees Of Dartmouth College Method for detecting intracellular cholesterol
WO2006060839A2 (en) 2004-12-10 2006-06-15 Universität Für Bodenkultur Wien Method for identifying ppt inhibitors
US7361483B2 (en) 2005-01-28 2008-04-22 The Salk Institute For Biological Studies Aromatic prenyltransferases, nucleic acids encoding same and uses therefor
US20080233628A1 (en) * 2006-09-14 2008-09-25 The Salk Institute For Biological Studies Incorporation of type III polyketide synthases into multidomain proteins of the type I and III polyketide synthase and fatty acid synthase families
CA2770774C (en) 2009-08-12 2020-07-14 National Research Council Of Canada Aromatic prenyltransferase from cannabis
WO2011127569A1 (en) 2010-04-14 2011-10-20 Voiceage Corporation Flexible and scalable combined innovation codebook for use in celp coder and decoder
CA3130705A1 (en) 2010-04-15 2011-10-20 National Research Council Of Canada Genes and proteins for aromatic polyketide synthesis
EP2601292B1 (en) 2010-08-06 2018-04-18 Biopetrolia AB Methods and products for production of wax esters
CN103562398A (zh) 2011-03-22 2014-02-05 Opx生物工艺学公司 化学产品的微生物生产以及相关的组合物、方法和系统
WO2013006853A1 (en) 2011-07-07 2013-01-10 Cidra Corporate Services Inc. Spectroscopic analysis of oil sands ore face for real time ore blend management
AU2012283708B2 (en) * 2011-07-13 2017-02-23 National Research Council Of Canada Genes and proteins for alkanoyl-CoA synthesis
BR112014010448A2 (pt) * 2011-11-02 2017-04-18 Genomatica Inc microorganismos e métodos para a produção de caprolactona
US9670494B2 (en) 2012-01-06 2017-06-06 Firmenich Sa Genetically engineered yeast cells
WO2014018982A1 (en) * 2012-07-27 2014-01-30 The Regents Of The University Of California Systems and methods for enhancing gene expression
WO2014134281A1 (en) 2013-02-28 2014-09-04 Full Spectrum Laboratories Limited Biosynthesis of cannabinoids
EP3008178A1 (en) 2013-06-14 2016-04-20 Technical University of Denmark Microbial production of 3-hydroxypropionic acid
WO2014207113A1 (en) 2013-06-26 2014-12-31 Abengoa Bioenergia Nuevas Tecnologias S.A. Yeasts engineered for the production of valuable chemicals from sugars
US20160230200A1 (en) 2013-09-05 2016-08-11 Danmarks Tekniske Universitet Microorganisms for efficient production of melatonin and related compounds
US9822384B2 (en) 2014-07-14 2017-11-21 Librede Inc. Production of cannabinoids in yeast
US9394510B2 (en) 2014-08-25 2016-07-19 Full Spectrum Laboratories Limited Apparatus and methods for the simultaneous production of compounds
DK3277827T3 (da) 2015-04-02 2021-06-14 Biopetrolia Ab Svampeceller og fremgangsmåder til fremstilling af produkter afledt af meget langkædede fedtsyrer
WO2017139496A1 (en) 2016-02-09 2017-08-17 Cevolva Biotech, Inc. Microbial engineering for the production of cannabinoids and cannabinoid precursors
EP3430151A4 (en) * 2016-03-16 2020-09-02 William Marsh Rice University MICROBIAL SYNTHESIS OF ISOPRENOID, ISOPRENOID AND DERIVATIVE PRECURSORS INCLUDING PRENYLATED AROMATIC COMPOUNDS
CN110914416B (zh) 2017-04-27 2023-07-21 加州大学董事会 产生大麻素和大麻素衍生物的微生物和方法

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