CN110651047B - 用于在酵母中生产植物大麻素和植物大麻素类似物的方法和细胞系 - Google Patents

用于在酵母中生产植物大麻素和植物大麻素类似物的方法和细胞系 Download PDF

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CN110651047B
CN110651047B CN201880025281.2A CN201880025281A CN110651047B CN 110651047 B CN110651047 B CN 110651047B CN 201880025281 A CN201880025281 A CN 201880025281A CN 110651047 B CN110651047 B CN 110651047B
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seq
phytocannabinoid
polynucleotide
methyl
yeast
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CN110651047A (zh
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肖哈姆·慕克吉
亚历山大·詹姆斯·坎贝尔
扎卡里·道格拉斯·威尔特希尔
凯文·约翰·陈
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Hague Senbio
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/08—Dihydroxy benzenes; Alkylated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
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    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1288—Transferases for other substituted phosphate groups (2.7.8)
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    • C12P7/00—Preparation of oxygen-containing organic compounds
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    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
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    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
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    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01041—Phosphoglycerol geranylgeranyltransferase (2.5.1.41)
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    • C12Y207/08—Transferases for other substituted phosphate groups (2.7.8)
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    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C12Y602/01001—Acetate-CoA ligase (6.2.1.1)

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Furan Compounds (AREA)
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201880025281.2A 2017-02-17 2018-02-19 用于在酵母中生产植物大麻素和植物大麻素类似物的方法和细胞系 Expired - Fee Related CN110651047B (zh)

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Application Number Priority Date Filing Date Title
US201762460526P 2017-02-17 2017-02-17
US62/460,526 2017-02-17
PCT/CA2018/050189 WO2018148848A1 (en) 2017-02-17 2018-02-19 Method and cell line for production of phytocannabinoids and phytocannabinoid analogues in yeast

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CN110651047B true CN110651047B (zh) 2024-01-05

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CN201880025692.1A Expired - Fee Related CN110637088B (zh) 2017-02-17 2018-02-19 用于在酵母中生产聚酮化合物的方法和细胞系

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US (3) US11078502B2 (https=)
EP (2) EP3583222A4 (https=)
JP (2) JP2020507351A (https=)
KR (2) KR20200004784A (https=)
CN (2) CN110651047B (https=)
AU (2) AU2018220470B2 (https=)
CA (2) CA3054423A1 (https=)
IL (2) IL268725B2 (https=)
MX (2) MX2019009708A (https=)
SG (2) SG11201907504PA (https=)
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