JP2020507351A - 酵母における植物性カンナビノイド及び植物性カンナビノイドアナログの生成のための方法及び細胞株 - Google Patents

酵母における植物性カンナビノイド及び植物性カンナビノイドアナログの生成のための方法及び細胞株 Download PDF

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JP2020507351A
JP2020507351A JP2019565595A JP2019565595A JP2020507351A JP 2020507351 A JP2020507351 A JP 2020507351A JP 2019565595 A JP2019565595 A JP 2019565595A JP 2019565595 A JP2019565595 A JP 2019565595A JP 2020507351 A JP2020507351 A JP 2020507351A
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seq
polynucleotide
enzyme
plant cannabinoid
plant
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ショハム・ムカジー
アレクサンダー・ジェームズ・キャンベル
ザカリー・ダグラス・ウィルトシャー
ケヴィン・ジョン・チェン
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ヒヤシンス・バイオロジカルス・インコーポレイテッド
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    • C07C39/02Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
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JP2019565595A 2017-02-17 2018-02-19 酵母における植物性カンナビノイド及び植物性カンナビノイドアナログの生成のための方法及び細胞株 Pending JP2020507351A (ja)

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US201762460526P 2017-02-17 2017-02-17
US62/460,526 2017-02-17
PCT/CA2018/050189 WO2018148848A1 (en) 2017-02-17 2018-02-19 Method and cell line for production of phytocannabinoids and phytocannabinoid analogues in yeast

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JP2019565596A Active JP7162018B6 (ja) 2017-02-17 2018-02-19 酵母におけるポリケチドの生成のための方法及び細胞株

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US (3) US11078502B2 (https=)
EP (2) EP3583222A4 (https=)
JP (2) JP2020507351A (https=)
KR (2) KR20200004784A (https=)
CN (2) CN110651047B (https=)
AU (2) AU2018220470B2 (https=)
CA (2) CA3054423A1 (https=)
IL (2) IL268725B2 (https=)
MX (2) MX2019009708A (https=)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115698272A (zh) * 2020-04-08 2023-02-03 哥本哈根大学 二磷酸香叶酯衍生的化合物的产生

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110914416B (zh) 2017-04-27 2023-07-21 加州大学董事会 产生大麻素和大麻素衍生物的微生物和方法
AU2018346434A1 (en) * 2017-10-05 2020-05-14 Intrexon Corporation Microorganisms and methods for the fermentation of cannabinoids
WO2019190945A1 (en) * 2018-03-29 2019-10-03 William Marsh Rice University Biosynthesis of olivetolic acid
AU2019262112A1 (en) 2018-04-30 2020-11-19 Algae-C Inc. Engineered microorganism for the production of cannabinoid biosynthetic pathway products
WO2020060948A1 (en) 2018-09-17 2020-03-26 Levadura Biotechnology, Inc. Production of cannabinoids in yeast using a fatty acid feedstock
IL326299A (en) * 2018-10-31 2026-04-01 Baymedica Inc Cannabinoid analogs and methods for their preparation
CN113227353A (zh) * 2018-11-14 2021-08-06 马努斯生物合成股份有限公司 用于产生大麻素的微生物细胞及方法
MY205459A (en) * 2018-12-06 2024-10-22 Cytomx Therapeutics Inc Matrix metalloprotease-cleavable and serine or cysteine protease-cleavable substrates and methods of use thereof
US20220127649A1 (en) * 2019-01-30 2022-04-28 Genomatica, Inc. Engineered cells for improved production of cannabinoids
EP3917642A4 (en) 2019-01-30 2023-04-05 Genomatica, Inc. RECOVERY, DECARBOXYLATION AND PURIFICATION OF CANNABINOIDS FROM GMO CULTURES
CA3130763A1 (en) 2019-02-25 2020-09-03 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
US20220186267A1 (en) * 2019-03-27 2022-06-16 Rynetech Bio, Inc. Biosynthetic Cannabidiol Production In Engineered Microorganisms
SG11202112690YA (en) * 2019-05-22 2021-12-30 Hyasynth Biologicals Inc Methods and cells for production of phytocannabinoids and phytocannabinoid precursors
ES3037766T3 (en) 2019-06-11 2025-10-07 Symrise Ag Synthesis and purification of cannabigerol and its application
CA3151799A1 (en) * 2019-08-18 2021-02-25 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
EP4025705A4 (en) * 2019-09-06 2024-01-17 Genomatica, Inc. PRENYL TRANSFERASE VARIANTS AND METHOD FOR PRODUCING PRENYLATED AROMATIC COMPOUNDS
CN120555521A (zh) * 2019-10-01 2025-08-29 杭州恩和生物科技有限公司 用于大麻素合成的酶和制备大麻素的方法
US20240084337A1 (en) * 2019-10-11 2024-03-14 National University Of Singapore Biosynthesis of cannabinoid precursors using novel aromatic prenyl transferases
KR20220079578A (ko) 2019-10-11 2022-06-13 내셔널 유니버시티 오브 싱가포르 신규 칸나비노이드 신타아제를 사용한 칸나비게롤산으로부터 칸나비노이드의 생합성
MX2022008463A (es) 2020-01-10 2022-10-18 Univ California Plataforma biosintética para la producción de ácido olivetólico y análogos del ácido olivetólico.
US20250346871A1 (en) * 2020-03-06 2025-11-13 Cellibre, Inc. Prenyltransferases and methods of making and use thereof
EP4126916A2 (en) 2020-03-27 2023-02-08 Willow Biosciences Inc. Compositions and methods for recombinant biosynthesis of cannabinoids
EP3901256A1 (en) * 2020-04-21 2021-10-27 Synbionik GmbH Optimized production of cbga from olivetol acid and geranyl pyrophosphate via synnphb
CA3175683A1 (en) 2020-04-29 2021-11-04 Xueyang FENG Compositions and methods for enhancing recombinant biosynthesis of cannabinoids
WO2021225952A1 (en) * 2020-05-08 2021-11-11 Lygos, Inc. Large scale production of olivetol, olivetolic acid and other alkyl resorcinols by fermentation
EP4176054A1 (en) * 2020-07-03 2023-05-10 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. -Hans-Knöll-Institut- (HKI) Method for producing olivetolic acid in an amoebozoa host species
KR20230042073A (ko) * 2020-07-24 2023-03-27 히야신스 바이오로지컬스 아이엔씨. 치환된 칸나비노이드 및 전구체를 제조하기 위해 변형 효소를 이용하는 방법 및 이를 함유하는 세포
CN111979134B (zh) 2020-08-28 2022-02-15 江南大学 一种合成胭脂红酸的重组酿酒酵母的构建及其应用
CN112042677B (zh) * 2020-09-21 2021-09-14 中国农业科学院麻类研究所 一种大麻叶提取物及其制备方法、用途
US11427840B2 (en) 2020-11-20 2022-08-30 Hyasynth Biologicals Inc. Olivetolic acid cyclase variants with improved activity for use in production of phytocannabinoids
CA3199891A1 (en) * 2020-11-24 2022-06-02 Ruth Gallily Cannabinoid derivatives and their use for the treatment of inflammation and/or pain and/or obesity
US20240026314A1 (en) * 2020-11-25 2024-01-25 Steven Rothstein Polypeptides for use in the synthesis of bioactive phenolic compounds
WO2022125960A1 (en) 2020-12-11 2022-06-16 Willow Biosciences, Inc. Recombinant acyl activating enzyme (aae) genes for enhanced biosynthesis of cannabinoids and cannabinoid precursors
EP4347800A1 (en) 2021-05-26 2024-04-10 Invizyne Technologies, Inc. Prenyltransferase variants with increased thermostability
WO2023010083A2 (en) 2021-07-30 2023-02-02 Willow Biosciences, Inc. Recombinant prenyltransferase polypeptides engineered for enhanced biosynthesis of cannabinoids
CA3227236A1 (en) 2021-08-19 2023-02-23 Trish Choudhary Recombinant olivetolic acid cyclase polypeptides engineered for enhanced biosynthesis of cannabinoids
CN113881584B (zh) * 2021-09-16 2023-06-27 广东省科学院微生物研究所(广东省微生物分析检测中心) 一株经航天育种技术选育的酿酒酵母及其突变位点应用
WO2023056350A1 (en) * 2021-09-29 2023-04-06 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
WO2023069921A1 (en) 2021-10-19 2023-04-27 Epimeron Usa, Inc. Recombinant thca synthase polypeptides engineered for enhanced biosynthesis of cannabinoids
CN114621982B (zh) * 2022-03-16 2023-11-07 嘉兴欣贝莱生物科技有限公司 香叶基二磷酸酯的生物合成方法及其在制备大麻类化合物中的应用
CN116024111B (zh) * 2022-12-03 2025-09-05 中国科学院深圳先进技术研究院 一种产大麻萜酚的微生物细胞及其构建方法与应用
CN119685467A (zh) * 2023-12-01 2025-03-25 上海市东方医院(同济大学附属东方医院) 诊断和治疗阿尔茨海默病的医药制剂
CN119753053A (zh) * 2025-03-07 2025-04-04 中国农业科学院植物保护研究所 磷酸泛酰巯基乙胺基转移酶3x32、其编码基因、含有该基因的重组载体和重组菌的应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE455785T1 (de) 2000-11-02 2010-02-15 Ajinomoto Kk Neue pyrazolderivate und diese enthaltende mittel gegen diabetes
US7238514B2 (en) 2001-01-05 2007-07-03 William Marsh Rice University Diterpene-producing unicellular organism
EP1338608A3 (en) * 2001-12-20 2004-05-06 Cellzome Ag Protein complexes and methods for their use
AU2002367554A1 (en) 2001-12-20 2003-09-09 Cellzome Ag Protein complexes and methods for their use
US7186519B2 (en) 2002-11-13 2007-03-06 Trustees Of Dartmouth College Method for detecting intracellular cholesterol
WO2006060839A2 (en) 2004-12-10 2006-06-15 Universität Für Bodenkultur Wien Method for identifying ppt inhibitors
US7361483B2 (en) 2005-01-28 2008-04-22 The Salk Institute For Biological Studies Aromatic prenyltransferases, nucleic acids encoding same and uses therefor
US20080233628A1 (en) * 2006-09-14 2008-09-25 The Salk Institute For Biological Studies Incorporation of type III polyketide synthases into multidomain proteins of the type I and III polyketide synthase and fatty acid synthase families
CA2770774C (en) 2009-08-12 2020-07-14 National Research Council Of Canada Aromatic prenyltransferase from cannabis
WO2011127569A1 (en) 2010-04-14 2011-10-20 Voiceage Corporation Flexible and scalable combined innovation codebook for use in celp coder and decoder
CA3130705A1 (en) 2010-04-15 2011-10-20 National Research Council Of Canada Genes and proteins for aromatic polyketide synthesis
EP2601292B1 (en) 2010-08-06 2018-04-18 Biopetrolia AB Methods and products for production of wax esters
CN103562398A (zh) 2011-03-22 2014-02-05 Opx生物工艺学公司 化学产品的微生物生产以及相关的组合物、方法和系统
WO2013006853A1 (en) 2011-07-07 2013-01-10 Cidra Corporate Services Inc. Spectroscopic analysis of oil sands ore face for real time ore blend management
AU2012283708B2 (en) * 2011-07-13 2017-02-23 National Research Council Of Canada Genes and proteins for alkanoyl-CoA synthesis
BR112014010448A2 (pt) * 2011-11-02 2017-04-18 Genomatica Inc microorganismos e métodos para a produção de caprolactona
US9670494B2 (en) 2012-01-06 2017-06-06 Firmenich Sa Genetically engineered yeast cells
WO2014018982A1 (en) * 2012-07-27 2014-01-30 The Regents Of The University Of California Systems and methods for enhancing gene expression
WO2014134281A1 (en) 2013-02-28 2014-09-04 Full Spectrum Laboratories Limited Biosynthesis of cannabinoids
EP3008178A1 (en) 2013-06-14 2016-04-20 Technical University of Denmark Microbial production of 3-hydroxypropionic acid
WO2014207113A1 (en) 2013-06-26 2014-12-31 Abengoa Bioenergia Nuevas Tecnologias S.A. Yeasts engineered for the production of valuable chemicals from sugars
US20160230200A1 (en) 2013-09-05 2016-08-11 Danmarks Tekniske Universitet Microorganisms for efficient production of melatonin and related compounds
US9822384B2 (en) 2014-07-14 2017-11-21 Librede Inc. Production of cannabinoids in yeast
US9394510B2 (en) 2014-08-25 2016-07-19 Full Spectrum Laboratories Limited Apparatus and methods for the simultaneous production of compounds
DK3277827T3 (da) 2015-04-02 2021-06-14 Biopetrolia Ab Svampeceller og fremgangsmåder til fremstilling af produkter afledt af meget langkædede fedtsyrer
WO2017139496A1 (en) 2016-02-09 2017-08-17 Cevolva Biotech, Inc. Microbial engineering for the production of cannabinoids and cannabinoid precursors
EP3430151A4 (en) * 2016-03-16 2020-09-02 William Marsh Rice University MICROBIAL SYNTHESIS OF ISOPRENOID, ISOPRENOID AND DERIVATIVE PRECURSORS INCLUDING PRENYLATED AROMATIC COMPOUNDS
CN110914416B (zh) 2017-04-27 2023-07-21 加州大学董事会 产生大麻素和大麻素衍生物的微生物和方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115698272A (zh) * 2020-04-08 2023-02-03 哥本哈根大学 二磷酸香叶酯衍生的化合物的产生

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