KR20190067280A - 전기수력학적으로 수득된 섬유를 포함하는 약학적 조성물, 적용 부위에서 향상된 체류 시간을 갖는 조성물 - Google Patents

전기수력학적으로 수득된 섬유를 포함하는 약학적 조성물, 적용 부위에서 향상된 체류 시간을 갖는 조성물 Download PDF

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KR20190067280A
KR20190067280A KR1020197016484A KR20197016484A KR20190067280A KR 20190067280 A KR20190067280 A KR 20190067280A KR 1020197016484 A KR1020197016484 A KR 1020197016484A KR 20197016484 A KR20197016484 A KR 20197016484A KR 20190067280 A KR20190067280 A KR 20190067280A
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South Korea
Prior art keywords
fiber
composition
fibers
bioadhesive
oral
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English (en)
Korean (ko)
Inventor
옌스 한센
마르틴 에두아르도 산토실데스 로메로
Original Assignee
에이에프와이엑스 테라퓨틱스 에스에이
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Publication of KR20190067280A publication Critical patent/KR20190067280A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
  • Nonwoven Fabrics (AREA)
KR1020197016484A 2015-11-19 2016-11-18 전기수력학적으로 수득된 섬유를 포함하는 약학적 조성물, 적용 부위에서 향상된 체류 시간을 갖는 조성물 Withdrawn KR20190067280A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201570745 2015-11-19
DKPA201570745 2015-11-19
PCT/EP2016/078151 WO2017085264A1 (en) 2015-11-19 2016-11-18 A pharmaceutical composition comprising electrohydrodynamically obtained fibres, the composition having improved residence time on the application site

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020187008505A Division KR102001163B1 (ko) 2015-11-19 2016-11-18 전기수력학적으로 수득된 섬유를 포함하는 약학적 조성물, 적용 부위에서 향상된 체류 시간을 갖는 조성물

Publications (1)

Publication Number Publication Date
KR20190067280A true KR20190067280A (ko) 2019-06-14

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ID=58718438

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020197016484A Withdrawn KR20190067280A (ko) 2015-11-19 2016-11-18 전기수력학적으로 수득된 섬유를 포함하는 약학적 조성물, 적용 부위에서 향상된 체류 시간을 갖는 조성물
KR1020187008505A Active KR102001163B1 (ko) 2015-11-19 2016-11-18 전기수력학적으로 수득된 섬유를 포함하는 약학적 조성물, 적용 부위에서 향상된 체류 시간을 갖는 조성물
KR1020197004754A Active KR102435996B1 (ko) 2015-11-19 2016-11-18 전기수력학적으로 수득된 섬유를 포함하는 약학적 조성물, 적용 부위에서 향상된 체류 시간을 갖는 조성물

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020187008505A Active KR102001163B1 (ko) 2015-11-19 2016-11-18 전기수력학적으로 수득된 섬유를 포함하는 약학적 조성물, 적용 부위에서 향상된 체류 시간을 갖는 조성물
KR1020197004754A Active KR102435996B1 (ko) 2015-11-19 2016-11-18 전기수력학적으로 수득된 섬유를 포함하는 약학적 조성물, 적용 부위에서 향상된 체류 시간을 갖는 조성물

Country Status (17)

Country Link
US (4) US20180221295A1 (enExample)
EP (1) EP3334412B1 (enExample)
JP (2) JP6606279B2 (enExample)
KR (3) KR20190067280A (enExample)
CN (1) CN108135833B (enExample)
AU (2) AU2016358266B2 (enExample)
BR (1) BR112018001978A2 (enExample)
CA (1) CA2993377C (enExample)
DK (1) DK3334412T3 (enExample)
ES (1) ES2900741T3 (enExample)
IL (1) IL258093B (enExample)
MX (1) MX391778B (enExample)
MY (1) MY167777A (enExample)
NZ (1) NZ740615A (enExample)
RU (2) RU2701513C2 (enExample)
SG (1) SG10201913222XA (enExample)
WO (1) WO2017085264A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2887977T3 (es) 2017-01-23 2021-12-29 Afyx Therapeutics As Método para la fabricación de un producto de dos capas a base de fibras electrohiladas
AU2018209592B2 (en) 2017-01-23 2024-03-21 Afyx Therapeutics A/S Method for preparing electrospun fibers with a high content of a bioadhesive substance
WO2021050532A1 (en) * 2019-09-09 2021-03-18 Afyx Therapeutics A/S Compositions for treating fungal infections
JP2022552832A (ja) 2019-10-08 2022-12-20 アフリックス セラピューティクス アー／エス タンパク質の送達のための組成物
EP4121017A4 (en) * 2020-03-17 2024-07-03 Blaesi, Aron H. EXPANDABLE, MULTI-EXCIPIENT STRUCTURED DOSAGE FORM FOR EXTENDED ACTIVE INGREDIENT RELEASE
US20220175812A1 (en) 2020-12-03 2022-06-09 Battelle Memorial Institute Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery
JP2024516108A (ja) 2021-04-07 2024-04-12 バテル・メモリアル・インスティテュート 非ウイルス性担体を同定および使用するための迅速な設計、構築、試験、および学習技術
EP4108231A1 (en) * 2021-06-25 2022-12-28 Johann-Wolfgang-Goethe-Universität Frankfurt am Main In-situ dissolving electrospun polymer fibers for ocular drug delivery
EP4124336B1 (en) * 2021-07-30 2023-10-25 Cannamedical Pharma GmbH Transmucosal patch comprising a cannabinoid and/or an opioid
JP2024542227A (ja) 2021-11-23 2024-11-13 アフリックス デベロップメント アー／エス 粘膜パッチおよびその使用方法
WO2024160792A1 (en) * 2023-01-30 2024-08-08 Cannamedical Pharma Gmbh Improved transmucosal patch comprising a cannabinoid and/or an opioid
WO2025051337A1 (en) 2023-09-06 2025-03-13 Afyx Development A/S Compositions and methods for treating and preventing oral cancer
WO2025072751A1 (en) 2023-09-29 2025-04-03 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
US12441996B2 (en) 2023-12-08 2025-10-14 Battelle Memorial Institute Use of DNA origami nanostructures for molecular information based data storage systems

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61280423A (ja) 1985-06-05 1986-12-11 Kiyuukiyuu Yakuhin Kogyo Kk 口腔内粘膜貼付剤
US6753454B1 (en) * 1999-10-08 2004-06-22 The University Of Akron Electrospun fibers and an apparatus therefor
JP2003521493A (ja) * 2000-01-28 2003-07-15 スミスクライン・ビーチャム・コーポレイション 電気紡糸された医薬組成物
US7309498B2 (en) * 2001-10-10 2007-12-18 Belenkaya Bronislava G Biodegradable absorbents and methods of preparation
US20030017208A1 (en) * 2002-07-19 2003-01-23 Francis Ignatious Electrospun pharmaceutical compositions
TW200410714A (en) * 2002-08-07 2004-07-01 Smithkline Beecham Corp Electrospun amorphous pharmaceutical compositions
AU2003265446A1 (en) * 2002-08-13 2004-02-25 Medtronic, Inc. Active agent delivery system including a hydrophilic polymer, medical device, and method
EP2271301A4 (en) * 2008-03-27 2014-07-02 Agigma Inc METHOD AND COMPOSITIONS FOR THE DELIVERY OF FUNDS
US20130295143A1 (en) * 2012-05-02 2013-11-07 Massachusetts Institute Of Technology Electroprocessing of active pharmaceutical ingredients
CN102670483B (zh) * 2012-05-09 2014-04-02 上海交通大学 一种用于高血脂症治疗的静电纺丝纤维膜制剂及其制备方法
WO2014066297A1 (en) * 2012-10-22 2014-05-01 North Carolina State University Nonwoven fiber materials
EP2810645B1 (en) * 2013-06-06 2017-05-24 A. Sezai Sarac New Drug Delivery System
CA2950821C (en) 2014-06-10 2024-02-06 Dermtreat Aps Compositions comprising electrohydrodynamically obtained fibres for administration of specific dosages of an active substance to skin or mucosa

Also Published As

Publication number Publication date
MY167777A (en) 2018-09-25
AU2016358266A1 (en) 2018-04-05
EP3334412B1 (en) 2021-10-20
CA2993377A1 (en) 2017-05-26
HK1256209A1 (en) 2019-09-13
RU2701513C2 (ru) 2019-09-27
KR20190020173A (ko) 2019-02-27
DK3334412T3 (da) 2022-01-17
CA2993377C (en) 2019-11-12
AU2018220020A1 (en) 2018-09-06
JP2018528256A (ja) 2018-09-27
US20240139117A1 (en) 2024-05-02
KR102001163B1 (ko) 2019-07-18
KR102435996B1 (ko) 2022-08-25
WO2017085264A1 (en) 2017-05-26
RU2018109496A (ru) 2019-09-19
AU2016358266B2 (en) 2018-06-21
US20180221295A1 (en) 2018-08-09
ES2900741T3 (es) 2022-03-18
RU2019129082A (ru) 2020-04-28
EP3334412A1 (en) 2018-06-20
US20230285313A1 (en) 2023-09-14
JP6606279B2 (ja) 2019-11-13
KR20180040704A (ko) 2018-04-20
CN108135833A (zh) 2018-06-08
NZ740615A (en) 2019-06-28
US20190254985A1 (en) 2019-08-22
BR112018001978A2 (pt) 2018-09-18
MX2018005206A (es) 2018-08-01
SG10201913222XA (en) 2020-03-30
JP6929916B2 (ja) 2021-09-01
AU2018220020C1 (en) 2020-09-17
RU2018109496A3 (enExample) 2019-09-19
IL258093A (en) 2018-05-31
IL258093B (en) 2022-03-01
CN108135833B (zh) 2022-11-29
MX391778B (es) 2025-03-21
JP2020022787A (ja) 2020-02-13
AU2018220020B2 (en) 2020-05-21

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Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20190607

Application number text: 1020187008505

Filing date: 20180326

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination