BR112018001978A2 - composição farmacêutica compreendendo fibras obtidas de forma eletro-hidrodinâ¬mica, composição com tempo de permanência melhorado sobre o local de aplicação - Google Patents
composição farmacêutica compreendendo fibras obtidas de forma eletro-hidrodinâ¬mica, composição com tempo de permanência melhorado sobre o local de aplicaçãoInfo
- Publication number
- BR112018001978A2 BR112018001978A2 BR112018001978A BR112018001978A BR112018001978A2 BR 112018001978 A2 BR112018001978 A2 BR 112018001978A2 BR 112018001978 A BR112018001978 A BR 112018001978A BR 112018001978 A BR112018001978 A BR 112018001978A BR 112018001978 A2 BR112018001978 A2 BR 112018001978A2
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- residence time
- time over
- application site
- pharmaceutical composition
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nanotechnology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Dermatology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nonwoven Fabrics (AREA)
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
Abstract
a presente invenção se refere a fibras fabricadas por eletro-fiação contendo: i) um primeiro e um segundo polímeros hidrofílicos formadores de fibra que são solúveis em um solvente hidrofílico; ii) uma substância bioadesiva que é pouco solúvel no referido solvente hidrofílico; iv) um fármaco, em que o primeiro polímero hidrofílico tem uma solubilidade em água a 37°c que é pelo menos algumas vezes maior do que a solubilidade em água a 37°c do segundo polímero hidrofílico formador de fibras, e em que a substância bioadesiva está presente em forma sólida.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201570745 | 2015-11-19 | ||
PCT/EP2016/078151 WO2017085264A1 (en) | 2015-11-19 | 2016-11-18 | A pharmaceutical composition comprising electrohydrodynamically obtained fibres, the composition having improved residence time on the application site |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018001978A2 true BR112018001978A2 (pt) | 2018-09-18 |
Family
ID=58718438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018001978A BR112018001978A2 (pt) | 2015-11-19 | 2016-11-18 | composição farmacêutica compreendendo fibras obtidas de forma eletro-hidrodinâ¬mica, composição com tempo de permanência melhorado sobre o local de aplicação |
Country Status (18)
Country | Link |
---|---|
US (4) | US20180221295A1 (pt) |
EP (1) | EP3334412B1 (pt) |
JP (2) | JP6606279B2 (pt) |
KR (3) | KR102435996B1 (pt) |
CN (1) | CN108135833B (pt) |
AU (2) | AU2016358266B2 (pt) |
BR (1) | BR112018001978A2 (pt) |
CA (1) | CA2993377C (pt) |
DK (1) | DK3334412T3 (pt) |
ES (1) | ES2900741T3 (pt) |
HK (1) | HK1256209A1 (pt) |
IL (1) | IL258093B (pt) |
MX (1) | MX2018005206A (pt) |
MY (1) | MY167777A (pt) |
NZ (1) | NZ740615A (pt) |
RU (2) | RU2701513C2 (pt) |
SG (1) | SG10201913222XA (pt) |
WO (1) | WO2017085264A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2019008258A (es) | 2017-01-23 | 2020-01-27 | Afyx Therapeutics As | Metodo para la fabricacion de un producto de dos capas basado en fibras electrohiladas. |
BR112019014732A2 (pt) | 2017-01-23 | 2020-03-10 | Afyx Therapeutics A/S | Método para a preparação de fibras eletrofiadas com um alto teor de uma substância bioadesiva |
WO2021050532A1 (en) * | 2019-09-09 | 2021-03-18 | Afyx Therapeutics A/S | Compositions for treating fungal infections |
US20240074970A1 (en) | 2019-10-08 | 2024-03-07 | Afyx Therapeutics A/S | Compositions for the delivery of proteins |
EP4108231A1 (en) * | 2021-06-25 | 2022-12-28 | Johann-Wolfgang-Goethe-Universität Frankfurt am Main | In-situ dissolving electrospun polymer fibers for ocular drug delivery |
PL4124336T3 (pl) * | 2021-07-30 | 2024-02-26 | Cannamedical Pharma Gmbh | Plaster przezśluzówkowy obejmujący kannabinoid i/lub opioid |
WO2023094457A1 (en) | 2021-11-23 | 2023-06-01 | Afyx Therapeutics A/S | Mucosal patches and methods of use thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61280423A (ja) | 1985-06-05 | 1986-12-11 | Kiyuukiyuu Yakuhin Kogyo Kk | 口腔内粘膜貼付剤 |
US6753454B1 (en) * | 1999-10-08 | 2004-06-22 | The University Of Akron | Electrospun fibers and an apparatus therefor |
CN1223340C (zh) * | 2000-01-28 | 2005-10-19 | 史密丝克莱恩比彻姆公司 | 电纺丝的药物组合物 |
US7309498B2 (en) * | 2001-10-10 | 2007-12-18 | Belenkaya Bronislava G | Biodegradable absorbents and methods of preparation |
US20030017208A1 (en) * | 2002-07-19 | 2003-01-23 | Francis Ignatious | Electrospun pharmaceutical compositions |
TW200410714A (en) * | 2002-08-07 | 2004-07-01 | Smithkline Beecham Corp | Electrospun amorphous pharmaceutical compositions |
AU2003265446A1 (en) * | 2002-08-13 | 2004-02-25 | Medtronic, Inc. | Active agent delivery system including a hydrophilic polymer, medical device, and method |
WO2009120365A2 (en) * | 2008-03-27 | 2009-10-01 | Agigma, Inc. | Methods and compositions for the delivery of agents |
WO2013165604A1 (en) * | 2012-05-02 | 2013-11-07 | Massachusetts Institute Of Technology | Electroprocessing of active pharmaceutical ingredients |
CN102670483B (zh) * | 2012-05-09 | 2014-04-02 | 上海交通大学 | 一种用于高血脂症治疗的静电纺丝纤维膜制剂及其制备方法 |
WO2014066297A1 (en) * | 2012-10-22 | 2014-05-01 | North Carolina State University | Nonwoven fiber materials |
EP2810645B1 (en) * | 2013-06-06 | 2017-05-24 | A. Sezai Sarac | New Drug Delivery System |
BR112016028961B1 (pt) * | 2014-06-10 | 2023-04-11 | Afyx Therapeutics A/S | Composição compreendendo fibras eletrotorcidas, seu método de preparação e kit |
-
2016
- 2016-11-18 JP JP2018516015A patent/JP6606279B2/ja active Active
- 2016-11-18 MY MYPI2018700176A patent/MY167777A/en unknown
- 2016-11-18 RU RU2018109496A patent/RU2701513C2/ru active
- 2016-11-18 SG SG10201913222XA patent/SG10201913222XA/en unknown
- 2016-11-18 CN CN201680046647.5A patent/CN108135833B/zh active Active
- 2016-11-18 KR KR1020197004754A patent/KR102435996B1/ko active IP Right Grant
- 2016-11-18 KR KR1020187008505A patent/KR102001163B1/ko active IP Right Grant
- 2016-11-18 WO PCT/EP2016/078151 patent/WO2017085264A1/en active Application Filing
- 2016-11-18 AU AU2016358266A patent/AU2016358266B2/en active Active
- 2016-11-18 CA CA2993377A patent/CA2993377C/en active Active
- 2016-11-18 RU RU2019129082A patent/RU2019129082A/ru unknown
- 2016-11-18 MX MX2018005206A patent/MX2018005206A/es unknown
- 2016-11-18 ES ES16797943T patent/ES2900741T3/es active Active
- 2016-11-18 KR KR1020197016484A patent/KR20190067280A/ko active Application Filing
- 2016-11-18 DK DK16797943.4T patent/DK3334412T3/da active
- 2016-11-18 EP EP16797943.4A patent/EP3334412B1/en active Active
- 2016-11-18 BR BR112018001978A patent/BR112018001978A2/pt not_active Application Discontinuation
- 2016-11-18 NZ NZ740615A patent/NZ740615A/en unknown
-
2018
- 2018-01-29 US US15/882,637 patent/US20180221295A1/en not_active Abandoned
- 2018-03-13 IL IL258093A patent/IL258093B/en unknown
- 2018-08-21 AU AU2018220020A patent/AU2018220020C1/en active Active
- 2018-11-29 HK HK18115318.3A patent/HK1256209A1/zh unknown
-
2019
- 2019-04-24 US US16/393,597 patent/US20190254985A1/en not_active Abandoned
- 2019-10-16 JP JP2019189500A patent/JP6929916B2/ja active Active
-
2023
- 2023-05-17 US US18/198,582 patent/US20230285313A1/en not_active Abandoned
-
2024
- 2024-01-05 US US18/406,022 patent/US20240139117A1/en active Pending
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25D | Requested change of name of applicant approved |
Owner name: DERMTREAT A/S (DK) |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B25D | Requested change of name of applicant approved |
Owner name: AFYX THERAPEUTICS A/S (DK) |
|
B25G | Requested change of headquarter approved |
Owner name: AFYX THERAPEUTICS A/S (DK) |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |