RU2019126497A - Способ получения электроспряденных волокон с высоким содержанием биоадгезивнго вещества - Google Patents
Способ получения электроспряденных волокон с высоким содержанием биоадгезивнго вещества Download PDFInfo
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- RU2019126497A RU2019126497A RU2019126497A RU2019126497A RU2019126497A RU 2019126497 A RU2019126497 A RU 2019126497A RU 2019126497 A RU2019126497 A RU 2019126497A RU 2019126497 A RU2019126497 A RU 2019126497A RU 2019126497 A RU2019126497 A RU 2019126497A
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- Prior art keywords
- bioadhesive
- fibers
- drug
- hydrophilic polymer
- peo
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- 239000000227 bioadhesive Substances 0.000 title claims 11
- 239000000835 fiber Substances 0.000 title claims 7
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 239000000126 substance Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims 14
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229920001477 hydrophilic polymer Polymers 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims 2
- 229920006243 acrylic copolymer Polymers 0.000 claims 2
- 150000001298 alcohols Chemical class 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 claims 1
- 241000416162 Astragalus gummifer Species 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 244000007835 Cyamopsis tetragonoloba Species 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 229920003134 Eudragit® polymer Polymers 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002148 Gellan gum Polymers 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 102000004856 Lectins Human genes 0.000 claims 1
- 108090001090 Lectins Proteins 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920002807 Thiomer Polymers 0.000 claims 1
- 229920001615 Tragacanth Polymers 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 235000010418 carrageenan Nutrition 0.000 claims 1
- 239000000679 carrageenan Substances 0.000 claims 1
- 229920001525 carrageenan Polymers 0.000 claims 1
- 229940113118 carrageenan Drugs 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 238000001523 electrospinning Methods 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229940014259 gelatin Drugs 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 229960000292 pectin Drugs 0.000 claims 1
- 239000002002 slurry Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 235000010487 tragacanth Nutrition 0.000 claims 1
- 239000000196 tragacanth Substances 0.000 claims 1
- 229940116362 tragacanth Drugs 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
- D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/02—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds
- D01F6/16—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from polymers of unsaturated carboxylic acids or unsaturated organic esters, e.g. polyacrylic esters, polyvinyl acetate
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/02—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds
- D01F6/26—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from other polymers
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/58—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products
- D01F6/62—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters
- D01F6/625—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters derived from hydroxy-carboxylic acids, e.g. lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/04—Homopolymers or copolymers of esters
- C08L33/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
- C08L39/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
- C08L39/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Textile Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Mechanical Engineering (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Artificial Filaments (AREA)
- Nonwoven Fabrics (AREA)
Claims (19)
1. Способ получения электроспряденных волокон, включающий
i) растворение волокнообразующего гидрофильного полимера в спирте, выбранном из C1-C3 спиртов,
ii) растворение биоадгезивного вещества в воде, где биоадгезивное вещество имеет растворимость в воде 3 г/100 мл или более при 25°С или 10 г/100 мл или более при 25°С, и где биоадгезивное вещество имеет растворимость в спирте, выбранном из С1-С3 спиртов, 0,5 г/100 мл или менее при 25°С или 0,1 г/100 мл или менее при 25°С,
iii) добавление при перемешивании полученного раствора с этапа ii) к полученному раствору с этапа i) с осаждением биоадгезивного вещества и формированием гомогенной суспензии, где биоадгезивное вещество суспендировано в виде частиц, и
iv) электропрядение гомогенной суспензии с получением гидрофильных волокон.
2. Способ по п.1, дополнительно включающий растворение или суспендирование лекарственного вещества на этапе i) или на эьапе ii).
3. Способ по п.1 или 2, где гидрофильный полимер выбран из группы, состоящей из поливинилпиррролидона, этилцеллюлозы, гидроксипропилцеллюлозы, акрилатов и акриловых сополимеров (Eudragit®) и их смесей.
4. Способ по любому из предшествующих пунктов, где биоадгезивное вещество выбрано из группы, состоящей из декстранов, полиэтиленоксидов (PEO), альгината, трагаканта, каррагенана, пектина, желатина, гуара, ксантана, геллана, метилцеллюлозы, гидроксипропилметилцеллюлозы (HPMC), поливинилового спирта (PVA), полимеров акриловых кислот (производные PAA), хитозана, лектинов, тиолированных полимеров, polyoxo WSRA, PAA-co-PEG (PEG представляет собой полиэтиленгликоль) и их смесей.
5. Способ по любому из предшествующих пунктов, где биоадгезивное вещество представляет собой PEO.
6. Способ по любому из предшествующих пунктов, где биоадгезивное вещество представляет собой PEO, имеющий молекулярную массу от приблизительно 100000 до приблизительно 500000 дальтон.
7. Способ по любому из предшествующих пунктов, где биоадгезивное вещество представляет собой полиэтиленоксид, имеющий молекулярную массу приблизительно 200000 дальтон.
8. Способ по п.1 или 2, где волокна содержат гидрофильный полимер, выбранный из поливинилпирролидона, акрилатов и акриловых сополимеров и их смесей.
9. Способ по любому из предшествующих пунктов, где концентрация волокнообразующего гидрофильного полимера(ов) в волокнах составляет от приблизительно 40% до приблизительно 70% масс./масс., в частности, от приблизительно 45 до приблизительно 70% масс./масс. или от приблизительно 50% до 70% масс./масс. в расчете на сумму общей сухой массы.
10. Способ по любому из предшествующих пунктов, где концентрация биоадгезивного вещества в волокнах составляет от приблизительно 30% до приблизительно 60% масс./масс., в частности, от приблизительно 35 до приблизительно 60% или от приблизительно 40% до приблизительно 55% масс./масс. в расчете на сумму общей сухой массы.
11. Способ по любому из предшествующих пунктов, где C1-C3 растворитель представляет собой этанол.
12. Способ по любому из предшествующих пунктов, где лекарственное вещество добавляют на этапе i).
13. Способ по любому из предшествующих пунктов, где лекарственное вещество представляет собой противовоспалительное лекарственное вещество.
14. Способ по любому из предшествующих пунктов, где лекарственное вещество представляет собой кортикостероид.
15. Способ по любому из предшествующих пунктов, дополнительно включающий этап контактирования электроспряденного гидрофильного волокна с электроспряденным гидрофобным слоем.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201770043 | 2017-01-23 | ||
| DKPA201770043 | 2017-01-23 | ||
| PCT/DK2018/050010 WO2018133910A1 (en) | 2017-01-23 | 2018-01-22 | Method for preparing electrospun fibers with a high content of a bioadhesive substance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2019126497A true RU2019126497A (ru) | 2021-02-24 |
| RU2019126497A3 RU2019126497A3 (ru) | 2021-05-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019126497A RU2019126497A (ru) | 2017-01-23 | 2018-01-22 | Способ получения электроспряденных волокон с высоким содержанием биоадгезивнго вещества |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11045430B2 (ru) |
| EP (1) | EP3570822B1 (ru) |
| JP (1) | JP7353980B2 (ru) |
| KR (1) | KR102595001B1 (ru) |
| CN (1) | CN110290783A (ru) |
| AU (1) | AU2018209592B2 (ru) |
| BR (1) | BR112019014732A2 (ru) |
| CA (1) | CA3050026A1 (ru) |
| DK (1) | DK3570822T3 (ru) |
| ES (1) | ES2874787T3 (ru) |
| IL (1) | IL268185B2 (ru) |
| MX (1) | MX2019008155A (ru) |
| RU (1) | RU2019126497A (ru) |
| WO (1) | WO2018133910A1 (ru) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2019121301A (ru) * | 2014-06-10 | 2019-08-20 | Афикс Терапьютикс А/С | Композиции, включающие электрогидродинамически полученные волокна, для нанесения заданных доз активного вещества на кожу или слизистую оболочку |
| BR112019014236A2 (pt) | 2017-01-23 | 2020-03-17 | Afyx Therapeutics A/S | Método para a fabricação de um produto de duas camadas à base de fibras eletrofiadas |
| CA3157209A1 (en) | 2019-10-08 | 2021-04-15 | Afyx Therapeutics A/S | Compositions for the delivery of proteins |
| ES2876401B2 (es) * | 2020-05-11 | 2024-04-05 | Bioinicia S L | Parches auto-adhesivos de fibras para la liberación controlada de bioactivos |
| AU2022395509A1 (en) | 2021-11-23 | 2024-06-13 | Afyx Development A/S | Mucosal patches and methods of use thereof |
| KR20240073700A (ko) | 2022-11-18 | 2024-05-27 | 한국생산기술연구원 | 다공성 폴리 유산 미세섬유 및 이의 제조방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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2018
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- 2018-01-22 EP EP18702052.4A patent/EP3570822B1/en active Active
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| IL268185A (en) | 2019-09-26 |
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| KR102595001B1 (ko) | 2023-10-26 |
| KR20190126306A (ko) | 2019-11-11 |
| AU2018209592B2 (en) | 2024-03-21 |
| CN110290783A (zh) | 2019-09-27 |
| WO2018133910A1 (en) | 2018-07-26 |
| IL268185B2 (en) | 2024-01-01 |
| DK3570822T3 (da) | 2021-07-26 |
| MX2019008155A (es) | 2019-11-07 |
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