DK3570822T3 - Fremgangsmåde til fremstilling af elektrospundne fibre med et højt indhold af et bioadhæsivt stof - Google Patents
Fremgangsmåde til fremstilling af elektrospundne fibre med et højt indhold af et bioadhæsivt stof Download PDFInfo
- Publication number
- DK3570822T3 DK3570822T3 DK18702052.4T DK18702052T DK3570822T3 DK 3570822 T3 DK3570822 T3 DK 3570822T3 DK 18702052 T DK18702052 T DK 18702052T DK 3570822 T3 DK3570822 T3 DK 3570822T3
- Authority
- DK
- Denmark
- Prior art keywords
- spunned
- bioad
- fibers
- procedure
- electronic
- Prior art date
Links
- 239000000853 adhesive Substances 0.000 title 1
- 230000001070 adhesive effect Effects 0.000 title 1
- 239000000835 fiber Substances 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
- D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/02—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds
- D01F6/16—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from polymers of unsaturated carboxylic acids or unsaturated organic esters, e.g. polyacrylic esters, polyvinyl acetate
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/02—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds
- D01F6/26—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from other polymers
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/58—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products
- D01F6/62—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters
- D01F6/625—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters derived from hydroxy-carboxylic acids, e.g. lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/04—Homopolymers or copolymers of esters
- C08L33/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
- C08L39/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
- C08L39/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Textile Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mechanical Engineering (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Artificial Filaments (AREA)
- Nonwoven Fabrics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201770043 | 2017-01-23 | ||
| PCT/DK2018/050010 WO2018133910A1 (en) | 2017-01-23 | 2018-01-22 | Method for preparing electrospun fibers with a high content of a bioadhesive substance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3570822T3 true DK3570822T3 (da) | 2021-07-26 |
Family
ID=58536695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18702052.4T DK3570822T3 (da) | 2017-01-23 | 2018-01-22 | Fremgangsmåde til fremstilling af elektrospundne fibre med et højt indhold af et bioadhæsivt stof |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11045430B2 (da) |
| EP (1) | EP3570822B1 (da) |
| JP (1) | JP7353980B2 (da) |
| KR (1) | KR102595001B1 (da) |
| CN (1) | CN110290783A (da) |
| AU (1) | AU2018209592B2 (da) |
| BR (1) | BR112019014732A2 (da) |
| CA (1) | CA3050026A1 (da) |
| DK (1) | DK3570822T3 (da) |
| ES (1) | ES2874787T3 (da) |
| IL (1) | IL268185B2 (da) |
| MX (1) | MX2019008155A (da) |
| RU (1) | RU2019126497A (da) |
| WO (1) | WO2018133910A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3622947A1 (en) * | 2014-06-10 | 2020-03-18 | Afyx Therapeutics A/S | Compositions comprising electrohydrodynamically obtained fibres for administration of specific dosages of an active substance to skin or mucosa |
| JP7162014B2 (ja) | 2017-01-23 | 2022-10-27 | アフリックス セラピューティクス アー／エス | 電界紡糸繊維に基づく２層生成物の製作方法 |
| CA3157209A1 (en) | 2019-10-08 | 2021-04-15 | Afyx Therapeutics A/S | Compositions for the delivery of proteins |
| ES2876401B2 (es) * | 2020-05-11 | 2024-04-05 | Bioinicia S L | Parches auto-adhesivos de fibras para la liberación controlada de bioactivos |
| CN118574602A (zh) | 2021-11-23 | 2024-08-30 | 阿费克斯发展有限公司 | 粘膜贴片及其使用方法 |
| KR20240073700A (ko) | 2022-11-18 | 2024-05-27 | 한국생산기술연구원 | 다공성 폴리 유산 미세섬유 및 이의 제조방법 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2134635Y (zh) | 1992-08-18 | 1993-05-26 | 许竞新 | 具有连续响声的印刷鞭炮 |
| DE4337152A1 (de) | 1993-10-30 | 1995-05-04 | Merck Patent Gmbh | Verfahren zur Herstellung von wäßrigen Chitosan-Lösungen und -Gelen |
| US6753454B1 (en) | 1999-10-08 | 2004-06-22 | The University Of Akron | Electrospun fibers and an apparatus therefor |
| CA2396640A1 (en) | 2000-01-28 | 2001-08-02 | Smithkline Beecham Corporation | Electrospun pharmaceutical compositions |
| JP2004531301A (ja) | 2001-03-22 | 2004-10-14 | バテル メモリアル インスティチュート | 溶解可能な製剤の製造 |
| US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
| US6585997B2 (en) | 2001-08-16 | 2003-07-01 | Access Pharmaceuticals, Inc. | Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds |
| US7309498B2 (en) | 2001-10-10 | 2007-12-18 | Belenkaya Bronislava G | Biodegradable absorbents and methods of preparation |
| US20030017208A1 (en) | 2002-07-19 | 2003-01-23 | Francis Ignatious | Electrospun pharmaceutical compositions |
| TW200410714A (en) | 2002-08-07 | 2004-07-01 | Smithkline Beecham Corp | Electrospun amorphous pharmaceutical compositions |
| AU2003265446A1 (en) | 2002-08-13 | 2004-02-25 | Medtronic, Inc. | Active agent delivery system including a hydrophilic polymer, medical device, and method |
| KR100564366B1 (ko) | 2003-11-19 | 2006-04-07 | 재단법인서울대학교산학협력재단 | 나노 섬유형 부직포를 이용한 조직 재생용 차폐막 및 그의 제조 방법 |
| JP4526851B2 (ja) | 2004-03-31 | 2010-08-18 | 明彦 谷岡 | 多糖類のナノスケールの繊維および成形体 |
| KR101228496B1 (ko) | 2004-10-06 | 2013-01-31 | 리서치 파운데이션 어브 서니 | 고유속 및 저오염의 여과매체 |
| US7390760B1 (en) | 2004-11-02 | 2008-06-24 | Kimberly-Clark Worldwide, Inc. | Composite nanofiber materials and methods for making same |
| WO2006106514A2 (en) | 2005-04-06 | 2006-10-12 | Nicast Ltd. | Electrospun dosage form and method of producing the same |
| WO2008069760A1 (en) | 2006-12-05 | 2008-06-12 | Nanyang Technological University | Three-dimensional porous hybrid scaffold and manufacture thereof |
| JP2009041117A (ja) | 2007-08-06 | 2009-02-26 | Nisshinbo Ind Inc | 多糖類ナノファイバー |
| US20100254961A1 (en) | 2007-09-05 | 2010-10-07 | Taiyokagaku Co., Ltd. | Water-soluble electrospun sheet |
| CA2719637C (en) | 2008-03-27 | 2014-10-28 | Agigma, Inc. | Methods and compositions for the delivery of agents |
| US8361492B2 (en) | 2008-04-29 | 2013-01-29 | Ocugenics, LLC | Drug delivery system and methods of use |
| WO2010099292A2 (en) | 2009-02-25 | 2010-09-02 | North Carolina State University | Biodegradable drug or other active delivery system |
| US20110111012A1 (en) | 2009-11-12 | 2011-05-12 | Hemcon Medical Technologies, Inc. | Nanomaterial wound dressing assembly |
| EP2646006B1 (en) | 2010-11-26 | 2015-02-25 | University Of The Witwatersrand, Johannesburg | A pharmaceutical dosage form |
| CN102251317B (zh) * | 2011-05-18 | 2013-01-16 | 东华大学 | 一种药物释放可控的电纺纤维的制备方法 |
| WO2013165604A1 (en) | 2012-05-02 | 2013-11-07 | Massachusetts Institute Of Technology | Electroprocessing of active pharmaceutical ingredients |
| US20150290354A1 (en) | 2012-10-22 | 2015-10-15 | North Carolina State University | Nonwoven fiber materials |
| US9393216B2 (en) | 2012-11-06 | 2016-07-19 | University Of Washington Through Its Center For Commercialization | Vaginal matrices: nanofibers for contraception and prevention of HIV infection |
| EP2810645B1 (en) | 2013-06-06 | 2017-05-24 | A. Sezai Sarac | New Drug Delivery System |
| EP2813212A1 (en) | 2013-06-10 | 2014-12-17 | Zentiva, a.s. | Drug formulation using API in nanofibers |
| CZ308492B6 (cs) | 2013-10-25 | 2020-09-23 | Contipro A.S. | Kosmetická kompozice na bázi kyseliny hyaluronové, způsob její přípravy a použití |
| CA2935237A1 (en) * | 2014-01-15 | 2015-07-23 | University Of Guelph | Compositions and methods to encapsulate and control release of volatile organic compounds for increasing shelf-life of perishable products |
| EP3151872B1 (en) | 2014-06-05 | 2018-12-12 | University Of The Witwatersrand, Johannesburg | Wound dressing |
| EP3622947A1 (en) | 2014-06-10 | 2020-03-18 | Afyx Therapeutics A/S | Compositions comprising electrohydrodynamically obtained fibres for administration of specific dosages of an active substance to skin or mucosa |
| US20160166959A1 (en) * | 2014-12-12 | 2016-06-16 | The Board Of Trustees Of The Leland Stanford Junior University | Air filter for high-efficiency pm2.5 capture |
| CA2993377C (en) * | 2015-11-19 | 2019-11-12 | Dermtreat Aps | A pharmaceutical composition comprising electrohydrodynamically obtained fibres, the composition having improved residence time on the application site |
-
2018
- 2018-01-22 EP EP18702052.4A patent/EP3570822B1/en active Active
- 2018-01-22 RU RU2019126497A patent/RU2019126497A/ru unknown
- 2018-01-22 BR BR112019014732-2A patent/BR112019014732A2/pt active Search and Examination
- 2018-01-22 MX MX2019008155A patent/MX2019008155A/es unknown
- 2018-01-22 CA CA3050026A patent/CA3050026A1/en active Pending
- 2018-01-22 WO PCT/DK2018/050010 patent/WO2018133910A1/en active Search and Examination
- 2018-01-22 ES ES18702052T patent/ES2874787T3/es active Active
- 2018-01-22 DK DK18702052.4T patent/DK3570822T3/da active
- 2018-01-22 JP JP2019560457A patent/JP7353980B2/ja active Active
- 2018-01-22 CN CN201880007823.3A patent/CN110290783A/zh active Pending
- 2018-01-22 AU AU2018209592A patent/AU2018209592B2/en active Active
- 2018-01-22 IL IL268185A patent/IL268185B2/en unknown
- 2018-01-22 KR KR1020197024907A patent/KR102595001B1/ko active IP Right Grant
-
2019
- 2019-04-26 US US16/395,956 patent/US11045430B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20190126306A (ko) | 2019-11-11 |
| EP3570822B1 (en) | 2021-05-05 |
| JP2020506307A (ja) | 2020-02-27 |
| RU2019126497A3 (da) | 2021-05-26 |
| IL268185A (en) | 2019-09-26 |
| CN110290783A (zh) | 2019-09-27 |
| AU2018209592B2 (en) | 2024-03-21 |
| EP3570822A1 (en) | 2019-11-27 |
| BR112019014732A2 (pt) | 2020-03-10 |
| MX2019008155A (es) | 2019-11-07 |
| JP7353980B2 (ja) | 2023-10-02 |
| CA3050026A1 (en) | 2018-07-26 |
| KR102595001B1 (ko) | 2023-10-26 |
| US11045430B2 (en) | 2021-06-29 |
| WO2018133910A1 (en) | 2018-07-26 |
| ES2874787T3 (es) | 2021-11-05 |
| IL268185B1 (en) | 2023-09-01 |
| IL268185B2 (en) | 2024-01-01 |
| AU2018209592A1 (en) | 2019-07-25 |
| RU2019126497A (ru) | 2021-02-24 |
| US20190254986A1 (en) | 2019-08-22 |
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