KR20180136588A - Lgr4, lgr5 및 lgr6 발현 상피 줄기 세포를 사용한 조직 응용에서의 최소 극성화 기능 세포 미소응집체 유닛의 개발 및 사용 방법 - Google Patents

Lgr4, lgr5 및 lgr6 발현 상피 줄기 세포를 사용한 조직 응용에서의 최소 극성화 기능 세포 미소응집체 유닛의 개발 및 사용 방법 Download PDF

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KR20180136588A
KR20180136588A KR1020187036619A KR20187036619A KR20180136588A KR 20180136588 A KR20180136588 A KR 20180136588A KR 1020187036619 A KR1020187036619 A KR 1020187036619A KR 20187036619 A KR20187036619 A KR 20187036619A KR 20180136588 A KR20180136588 A KR 20180136588A
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tissue
lgr6
cell
lgr
wound
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덴버 엠. 로크
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폴래러티티이, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
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    • A—HUMAN NECESSITIES
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    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/362—Skin, e.g. dermal papillae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture

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  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
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  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Developmental Biology & Embryology (AREA)
KR1020187036619A 2014-12-02 2015-12-01 Lgr4, lgr5 및 lgr6 발현 상피 줄기 세포를 사용한 조직 응용에서의 최소 극성화 기능 세포 미소응집체 유닛의 개발 및 사용 방법 Ceased KR20180136588A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462086526P 2014-12-02 2014-12-02
US62/086,526 2014-12-02
US14/954,335 2015-11-30
US14/954,335 US10926001B2 (en) 2014-12-02 2015-11-30 Methods related to minimally polarized functional units
PCT/US2015/063114 WO2016089825A1 (en) 2014-12-02 2015-12-01 Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells

Related Parent Applications (1)

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KR1020177017887A Division KR20170098844A (ko) 2014-12-02 2015-12-01 Lgr4, lgr5 및 lgr6 발현 상피 줄기 세포를 사용한 조직 응용에서의 최소 극성화 기능 세포 미소응집체 유닛의 개발 및 사용 방법

Publications (1)

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KR20180136588A true KR20180136588A (ko) 2018-12-24

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Family Applications (5)

Application Number Title Priority Date Filing Date
KR1020187036619A Ceased KR20180136588A (ko) 2014-12-02 2015-12-01 Lgr4, lgr5 및 lgr6 발현 상피 줄기 세포를 사용한 조직 응용에서의 최소 극성화 기능 세포 미소응집체 유닛의 개발 및 사용 방법
KR1020197028100A Ceased KR20190111167A (ko) 2014-12-02 2015-12-01 Lgr4, lgr5 및 lgr6 발현 상피 줄기 세포를 사용한 조직 응용에서의 최소 극성화 기능 세포 미소응집체 유닛의 개발 및 사용 방법
KR1020187036618A Ceased KR20180136587A (ko) 2014-12-02 2015-12-01 Lgr4, lgr5 및 lgr6 발현 상피 줄기 세포를 사용한 조직 응용에서의 최소 극성화 기능 세포 미소응집체 유닛의 개발 및 사용 방법
KR1020177017887A Ceased KR20170098844A (ko) 2014-12-02 2015-12-01 Lgr4, lgr5 및 lgr6 발현 상피 줄기 세포를 사용한 조직 응용에서의 최소 극성화 기능 세포 미소응집체 유닛의 개발 및 사용 방법
KR1020217010934A Ceased KR20210043024A (ko) 2014-12-02 2015-12-01 Lgr4, lgr5 및 lgr6 발현 상피 줄기 세포를 사용한 조직 응용에서의 최소 극성화 기능 세포 미소응집체 유닛의 개발 및 사용 방법

Family Applications After (4)

Application Number Title Priority Date Filing Date
KR1020197028100A Ceased KR20190111167A (ko) 2014-12-02 2015-12-01 Lgr4, lgr5 및 lgr6 발현 상피 줄기 세포를 사용한 조직 응용에서의 최소 극성화 기능 세포 미소응집체 유닛의 개발 및 사용 방법
KR1020187036618A Ceased KR20180136587A (ko) 2014-12-02 2015-12-01 Lgr4, lgr5 및 lgr6 발현 상피 줄기 세포를 사용한 조직 응용에서의 최소 극성화 기능 세포 미소응집체 유닛의 개발 및 사용 방법
KR1020177017887A Ceased KR20170098844A (ko) 2014-12-02 2015-12-01 Lgr4, lgr5 및 lgr6 발현 상피 줄기 세포를 사용한 조직 응용에서의 최소 극성화 기능 세포 미소응집체 유닛의 개발 및 사용 방법
KR1020217010934A Ceased KR20210043024A (ko) 2014-12-02 2015-12-01 Lgr4, lgr5 및 lgr6 발현 상피 줄기 세포를 사용한 조직 응용에서의 최소 극성화 기능 세포 미소응집체 유닛의 개발 및 사용 방법

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US (7) US10926001B2 (https=)
EP (2) EP4438128A3 (https=)
JP (3) JP6791854B2 (https=)
KR (5) KR20180136588A (https=)
CN (1) CN107250348B (https=)
AU (3) AU2015355187C1 (https=)
BR (1) BR112017011808A2 (https=)
CA (1) CA2969707C (https=)
CO (1) CO2017006640A2 (https=)
CR (1) CR20170296A (https=)
EA (1) EA201791125A1 (https=)
GB (2) GB2569056B (https=)
HK (1) HK1250515A1 (https=)
IL (2) IL252613B (https=)
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WO (1) WO2016089825A1 (https=)
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AU2019240603B2 (en) 2023-02-09
EP4438128A2 (en) 2024-10-02
IL252613A0 (en) 2017-07-31
MX2023001655A (es) 2023-04-24
JP6791854B2 (ja) 2020-11-25
GB201902819D0 (en) 2019-04-17
PH12017501009B1 (en) 2022-01-21
CA2969707C (en) 2019-08-20
US11000629B2 (en) 2021-05-11
AU2015355187B2 (en) 2019-10-03
GB2569056A (en) 2019-06-05
GB2549872A (en) 2017-11-01
US20220241464A1 (en) 2022-08-04
WO2016089825A1 (en) 2016-06-09
PH12017501009A1 (en) 2017-12-11
CA2969707A1 (en) 2016-06-09
EP3227431C0 (en) 2025-01-29
IL287488B2 (en) 2023-06-01
AU2015355187C1 (en) 2020-02-20
CN107250348A (zh) 2017-10-13
HK1245327A1 (zh) 2018-08-24
EP3227431A4 (en) 2019-01-02
JP2020182880A (ja) 2020-11-12
US20210322643A1 (en) 2021-10-21
GB2569056B (en) 2020-01-01
MY184931A (en) 2021-04-30
EP3227431B1 (en) 2025-01-29
KR20190111167A (ko) 2019-10-01
KR20210043024A (ko) 2021-04-20
CO2017006640A2 (es) 2017-11-21
CN107250348B (zh) 2021-09-03
AU2019240603A1 (en) 2019-10-17
NZ755260A (en) 2021-12-24
US20180154043A1 (en) 2018-06-07
AU2023202857A1 (en) 2023-05-25
NZ733433A (en) 2019-08-30
US20230181797A1 (en) 2023-06-15
EP4438128A3 (en) 2024-11-13
KR20180136587A (ko) 2018-12-24
HK1250515A1 (zh) 2018-12-21
SG11201704502RA (en) 2017-06-29
JP2019088299A (ja) 2019-06-13
ZA201703907B (en) 2023-03-29
US11596714B2 (en) 2023-03-07
US10926001B2 (en) 2021-02-23
AU2015355187A1 (en) 2017-06-29
GB201710646D0 (en) 2017-08-16
KR20170098844A (ko) 2017-08-30
MX2017007243A (es) 2018-01-25
IL287488A (en) 2021-12-01
IL252613B (en) 2021-12-01
US20180154044A1 (en) 2018-06-07
US11266765B2 (en) 2022-03-08
US20190046691A1 (en) 2019-02-14
US20160151540A1 (en) 2016-06-02
JP2017538411A (ja) 2017-12-28
EA201791125A1 (ru) 2018-06-29
US11338060B2 (en) 2022-05-24
BR112017011808A2 (pt) 2018-02-27
CR20170296A (es) 2018-01-25
EP3227431A1 (en) 2017-10-11
US12465669B2 (en) 2025-11-11

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