KR20170128640A - 주사용의 안정한 보존제-비함유 산동 및 항-염증 용액 - Google Patents

주사용의 안정한 보존제-비함유 산동 및 항-염증 용액 Download PDF

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Publication number
KR20170128640A
KR20170128640A KR1020177033129A KR20177033129A KR20170128640A KR 20170128640 A KR20170128640 A KR 20170128640A KR 1020177033129 A KR1020177033129 A KR 1020177033129A KR 20177033129 A KR20177033129 A KR 20177033129A KR 20170128640 A KR20170128640 A KR 20170128640A
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South Korea
Prior art keywords
formulation
concentration
surgery
pharmaceutical formulation
buffer
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Ceased
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KR1020177033129A
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English (en)
Korean (ko)
Inventor
그레고리 에이. 데모풀로스
후이-롱 센
클라크 이. 테드퍼드
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오메로스 코포레이션
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50545210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20170128640(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 오메로스 코포레이션 filed Critical 오메로스 코포레이션
Publication of KR20170128640A publication Critical patent/KR20170128640A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/08—Mydriatics or cycloplegics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
KR1020177033129A 2012-10-24 2013-10-23 주사용의 안정한 보존제-비함유 산동 및 항-염증 용액 Ceased KR20170128640A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261718026P 2012-10-24 2012-10-24
US61/718,026 2012-10-24
US201261736179P 2012-12-12 2012-12-12
US61/736,179 2012-12-12
PCT/US2013/066349 WO2014066485A1 (en) 2012-10-24 2013-10-23 Stable preservative-free mydriatic and anti-inflammatory solutions for injection

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020157012282A Division KR101808394B1 (ko) 2012-10-24 2013-10-23 주사용의 안정한 보존제-비함유 산동 및 항-염증 용액

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020197038220A Division KR102211784B1 (ko) 2012-10-24 2013-10-23 주사용의 안정한 보존제-비함유 산동 및 항-염증 용액

Publications (1)

Publication Number Publication Date
KR20170128640A true KR20170128640A (ko) 2017-11-22

Family

ID=50545210

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020177033129A Ceased KR20170128640A (ko) 2012-10-24 2013-10-23 주사용의 안정한 보존제-비함유 산동 및 항-염증 용액
KR1020217002992A Active KR102496463B1 (ko) 2012-10-24 2013-10-23 주사용의 안정한 보존제-비함유 산동 및 항-염증 용액
KR1020197038220A Active KR102211784B1 (ko) 2012-10-24 2013-10-23 주사용의 안정한 보존제-비함유 산동 및 항-염증 용액
KR1020157012282A Active KR101808394B1 (ko) 2012-10-24 2013-10-23 주사용의 안정한 보존제-비함유 산동 및 항-염증 용액

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR1020217002992A Active KR102496463B1 (ko) 2012-10-24 2013-10-23 주사용의 안정한 보존제-비함유 산동 및 항-염증 용액
KR1020197038220A Active KR102211784B1 (ko) 2012-10-24 2013-10-23 주사용의 안정한 보존제-비함유 산동 및 항-염증 용액
KR1020157012282A Active KR101808394B1 (ko) 2012-10-24 2013-10-23 주사용의 안정한 보존제-비함유 산동 및 항-염증 용액

Country Status (39)

Country Link
US (6) US9066856B2 (en:Method)
EP (2) EP3909572B1 (en:Method)
JP (8) JP6017053B2 (en:Method)
KR (4) KR20170128640A (en:Method)
CN (2) CN104822265A (en:Method)
AP (1) AP2015008459A0 (en:Method)
AR (1) AR093115A1 (en:Method)
AU (1) AU2013201465B2 (en:Method)
BR (1) BR112015009228B1 (en:Method)
CA (1) CA2887772C (en:Method)
CL (1) CL2015001078A1 (en:Method)
CR (1) CR20150233A (en:Method)
CU (1) CU20150037A7 (en:Method)
CY (1) CY1124481T1 (en:Method)
DK (1) DK2911511T3 (en:Method)
EA (1) EA033811B1 (en:Method)
ES (1) ES2875432T3 (en:Method)
GE (1) GEP20186891B (en:Method)
HR (1) HRP20210980T1 (en:Method)
HU (1) HUE055537T2 (en:Method)
IL (1) IL238439B2 (en:Method)
IN (1) IN2015DN03029A (en:Method)
LT (1) LT2911511T (en:Method)
MA (1) MA38096B1 (en:Method)
MD (1) MD20150050A2 (en:Method)
MX (2) MX2020012591A (en:Method)
MY (2) MY204103A (en:Method)
NZ (1) NZ628398A (en:Method)
PE (1) PE20150958A1 (en:Method)
PH (1) PH12015500850B1 (en:Method)
PL (1) PL2911511T3 (en:Method)
PT (1) PT2911511T (en:Method)
RS (1) RS62188B1 (en:Method)
SG (1) SG11201502602WA (en:Method)
SI (1) SI2911511T1 (en:Method)
SM (1) SMT202100393T1 (en:Method)
UA (1) UA114650C2 (en:Method)
WO (1) WO2014066485A1 (en:Method)
ZA (1) ZA201502684B (en:Method)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1684701B (zh) 2002-07-30 2012-10-17 奥默罗斯公司 眼科冲洗液及方法
AU2013201465B2 (en) * 2012-10-24 2016-03-03 Rayner Intraocular Lenses Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
US20210346318A1 (en) * 2013-10-03 2021-11-11 Harrow Ip, Llc Epinephrine-based ophthalmic compositions for intraocular administration and methods for fabricating thereof
BR112016007328A2 (pt) 2013-10-03 2017-08-01 Imprimis Pharmaceuticals Inc composições oftálmicas baseadas em epinefrina para administração intraocular e métodos para fabricar as mesmas
TWI809304B (zh) * 2014-12-01 2023-07-21 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液
CN104856990A (zh) * 2015-05-07 2015-08-26 武汉武药科技有限公司 去氧肾上腺素酮咯酸溶液及制备方法
US11213480B1 (en) 2015-08-06 2022-01-04 Hikma Pharmaceuticals International Limited Phenylephrine hydrochloride ready-to-use solution
USD831868S1 (en) 2015-09-17 2018-10-23 Lume Cube, Inc. Compact external light
US10704745B2 (en) 2015-10-13 2020-07-07 Lume Cube, Inc. Mobile light source
EP3503873A4 (en) 2016-08-25 2020-04-15 Harrow IP, LLC EPINEPHRINE-BASED OPHTHALMIC COMPOSITIONS FOR INTRAOCULAR ADMINISTRATION AND METHOD FOR THE PRODUCTION THEREOF
US20180318319A1 (en) * 2017-05-04 2018-11-08 Ocular Science, Inc. Compositions and Methods for Treating Eyes and Methods of Preparation
JP7078843B2 (ja) * 2018-03-26 2022-06-01 サミー株式会社 遊技機
BR112021007725A2 (pt) * 2018-10-26 2021-07-27 Ocuphire Pharma, Inc. métodos e composições para tratamento de presbiopia, midríase e outros distúrbios oculares
US11071724B2 (en) 2019-05-17 2021-07-27 Ocular Science, Inc. Compositions and methods for treating presbyopia
DE102019125430B3 (de) * 2019-09-20 2020-11-19 Carl Zeiss Meditec Ag Steuerungsvorrichtung für ein ophthalmochirurgisches System, ophthalmochirurgisches System sowie Computerprogrammprodukt
KR102749980B1 (ko) 2020-01-02 2025-01-03 삼성전자주식회사 에어 스페이서를 가지는 반도체 소자
WO2021150747A1 (en) * 2020-01-22 2021-07-29 Nevakar Inc. Phenylephrine hydrochloride compositions and containers
WO2022132567A1 (en) * 2020-12-17 2022-06-23 Harrow Ip, Llc Mydriatic compositions and methods for fabricating thereof
CN115368310B (zh) 2021-05-18 2025-06-27 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法
US12029729B2 (en) 2021-07-23 2024-07-09 Somerset Therapeutics, Llc Chelated, stable ophthalmological compositions of ketorolac and phenylephrine and applications thereof
US11883382B2 (en) 2021-07-23 2024-01-30 Somerset Therapeutics, Llc Buffer-free ophthalmological compositions of ketorolac and phenylephrine and applications thereof
WO2024086268A1 (en) * 2022-10-19 2024-04-25 Fresenius Kabi Austria Gmbh Phenylephrine liquid formulations
CN115950992B (zh) * 2023-03-15 2023-06-09 苏州朗易生物医药研究有限公司 一种去氧肾上腺素酮咯酸溶液中有关物质的检测方法及其应用
WO2025165753A1 (en) * 2024-01-31 2025-08-07 Hikma Pharmaceuticals Usa Inc. Pharmaceutical formulations of phenylephrine and process of making the same

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4402949A (en) 1979-11-12 1983-09-06 Sandoz Ltd. Stable solutions of hydrogenated ergotalkaloids
US4550022A (en) 1981-10-05 1985-10-29 Alcon Laboratories, Inc. Tissue irrigating solution
JPS58126810A (ja) 1981-12-24 1983-07-28 Kaken Pharmaceut Co Ltd 抗炎症眼科用液剤およびその製法
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
JPS6017053U (ja) 1983-07-11 1985-02-05 住友電気工業株式会社 伝送エラ−検出器
WO1987007141A1 (en) 1986-05-23 1987-12-03 New England Medical Center Hospitals, Inc. Method for treating glaucoma
US5212196A (en) 1986-10-21 1993-05-18 Alcon Laboratories, Inc. Control of post-surgical intraocular pressure using clonidine derivatives
US4938970A (en) 1987-02-06 1990-07-03 Hustead Robert E Painless electrolyte solutions
US5110493A (en) 1987-09-11 1992-05-05 Syntex (U.S.A.) Inc. Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
US4876250A (en) 1988-10-31 1989-10-24 Alcon Laboratories, Inc. Methods for controlling ocular hypertension with angiostatic steroids
DE3833893A1 (de) 1988-10-05 1990-04-12 Bayer Ag Verwendung von basischen nitro-phenyl-dihydropyridin-amiden als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung ueber neue zwischenprodukte
US5051443A (en) 1988-10-12 1991-09-24 Eye Research Institute Of Retina Foundation, Inc. Method for enhancing healing of corneal endothelial wounds
US5036046A (en) 1988-10-12 1991-07-30 Eye Research Institute Of Retina Foundation, Inc. Method for enhancing healing of corneal endothelial wounds
US5371078A (en) 1988-10-31 1994-12-06 Alcon Laboratories, Inc. Angiostatic steroids and methods and compositions for controlling ocular hypertension
US5116868A (en) 1989-05-03 1992-05-26 The Johns Hopkins University Effective ophthalmic irrigation solution
CA2065375A1 (en) 1989-08-21 1991-02-22 Richard J. Sharpe Method and composition for the treatment of cutaneous, ocular, and mucosal hypersensitivity, inflammation, and hyperproliferative conditions using topical preparations of serotonin antagonists
US5679650A (en) * 1993-11-24 1997-10-21 Fukunaga; Atsuo F. Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine
DE69114470T2 (de) 1990-09-07 1996-07-18 Univ Alicante Komposition für die behandlung von augenschmerzen.
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
IT1252692B (it) 1991-11-27 1995-06-23 Zambon Spa Composizione farmaceutica per uso oftalmico contenente un antiinfiammatorio non steroideo ed un decongestionante come principi attivi
CA2126093A1 (en) 1992-10-21 1994-04-28 Owen Gan Composition for irrigating intraocular tissues and maintaining mydriasis during intraocular surgery
US6117907A (en) 1993-04-14 2000-09-12 Sher; Neal A. Topical treatment of ocular pain after corneal surgery
CA2149657A1 (en) 1993-09-29 1995-04-06 Billie M. York Compositions containing growth factors and antiplastic agents
AU7846794A (en) 1993-09-29 1995-04-18 Alcon Laboratories, Inc. Compositions containing growth factors and antimetabolites
US5624893A (en) 1993-10-14 1997-04-29 Alcon Laboratories, Inc. Pharmaceutical compositions and methods of treatment of the cornea following laser irradiation
JPH09506620A (ja) 1993-12-17 1997-06-30 アルコン・ラボラトリーズ，インコーポレイテッド 非ステロイド抗炎症剤を含有する改良された眼内洗浄溶液
US6350781B1 (en) 1994-01-14 2002-02-26 Lee Shahinia, Jr. Method and analgesic preparations for sustained and extended corneal analgesia with subanesthetic concentrations of lidocaine
WO1995034298A1 (en) 1994-06-10 1995-12-21 Telor Ophthalmic Pharmaceuticals, Inc. Inhibition of intraoperative miosis/production of mydriasis by local anesthetics
US5523316A (en) 1994-06-23 1996-06-04 Alcon Laboratories, Inc. Intraocular irrigating solution containing agent for controlling IOP
US6492332B1 (en) 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
KR100517210B1 (ko) 1994-12-12 2006-06-07 오메로스 코포레이션 통증,염증및경련억제용관주용액
WO2000023061A2 (en) 1998-10-21 2000-04-27 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
US7091181B2 (en) 1994-12-12 2006-08-15 Omeros Corporation Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
WO2000023072A1 (en) 1998-10-20 2000-04-27 Omeros Medical Systems, Inc. Irrigation solution containing mapk inhibitors and their use for treating pain and inflammation
RU2180852C2 (ru) 1994-12-12 2002-03-27 Омерос Медикл Системс, Инк. Ингибирующий раствор и способ подавления боли, воспаления или спазма
JPH10510540A (ja) 1994-12-12 1998-10-13 オメロス メディカル システムズ，インコーポレーテッド 灌注用溶液並びに疼痛、炎症及びけいれんの抑制法
US5972326A (en) 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
US5612027A (en) 1995-04-18 1997-03-18 Galin; Miles A. Controlled release of miotic and mydriatic drugs in the anterior chamber
US5767105A (en) 1995-05-03 1998-06-16 Peyman; Gholam A. Ocular solution
US5798356A (en) 1995-08-07 1998-08-25 Alcon Laboratories, Inc. Angiostatic compounds
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6413961B1 (en) 1995-12-12 2002-07-02 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
US6280745B1 (en) 1997-12-23 2001-08-28 Alliance Pharmaceutical Corp. Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions
EP1039818A4 (en) 1996-07-26 2001-11-07 Schein Dental Equipment Co ARMREST MECHANISM FOR DENTAL ARMCHAIRS
GB9704352D0 (en) 1997-03-03 1997-04-23 Chiroscience Ltd Levobupivacaine and its use
AU6883798A (en) 1997-04-02 1998-10-22 Regents Of The University Of California, The Method of anesthesia
US5811446A (en) 1997-04-18 1998-09-22 Cytos Pharmaceuticals Llc Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor
US6034256A (en) 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
US6495598B1 (en) 1997-04-22 2002-12-17 Ophtecs Corporation Perfusate preparation for ophthalmic operation
EP0903151A1 (en) 1997-09-22 1999-03-24 ASTA Medica Aktiengesellschaft Use of combinations comprising non-sedating antihistamines and alpha-adrenergic drugs for the topical treatment of rhinitis/conjunctivitis and cold, cold-like and/or flu symptoms
DE69928806T2 (de) 1998-07-01 2006-07-20 Warner-Lambert Co. Llc (-)-pseudoephedrin als sympathomimetisches arzneimittel
ATE203668T1 (de) 1998-07-14 2001-08-15 Alcon Lab Inc Verwendung von 11-(3-dimethylaminopropyliden)-6, 11-dihydrodibenz(b,e)oxepin-2-essigsäure und deren pharmazeutisch annehmbaren salzen zur herstellung eines medikaments zur behandlung nicht-allergisch-bedingten augenentzündungen und zur prevention der okularen neovaskularisation
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
FR2782721B1 (fr) 1998-09-01 2000-11-03 Inst Nat Sante Rech Med Nouveaux composes phosphohalohydrines, procede de fabrication et applications
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
EP1434573A2 (en) 1998-10-20 2004-07-07 Omeros Corporation Irrigation solution and method for inhibition of pain and inflammation
US20030087962A1 (en) 1998-10-20 2003-05-08 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
AU1319200A (en) 1998-10-20 2000-05-08 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
US7973068B2 (en) 1998-10-20 2011-07-05 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
EP1206275B1 (en) 1998-11-05 2007-09-05 Omeros Corporation Irrigation solution and method for inhibition of pain and inflammation
WO2000035433A2 (en) 1998-12-17 2000-06-22 Alcon Laboratories, Inc. Methods for the prevention and treatment of post-surgical complications
KR20010108296A (ko) * 1999-03-02 2001-12-07 출원후보충 눈의 질병을 치료 또는 예방하기 위한 유리체내 투여용 약제
CN1353573A (zh) 1999-05-14 2002-06-12 加利福尼亚大学董事会 对炎症介导感染的抗炎症治疗
AU5286901A (en) 1999-10-22 2001-06-18 Transdermatech, Inc. Topical anesthetic formulation
US6218428B1 (en) 2000-04-28 2001-04-17 Emil Chynn Ophthalmic composition
JP2004512260A (ja) 2000-04-28 2004-04-22 メモリアル　スローン−ケッタリング　キャンサー　センター 局所麻酔／オピオイド製剤およびその使用方法
US20020128267A1 (en) 2000-07-13 2002-09-12 Rebanta Bandyopadhyay Method of using COX-2 inhibitors in the treatment and prevention of ocular COX-2 mediated disorders
PE20020146A1 (es) 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
JP2004503593A (ja) 2000-07-14 2004-02-05 アラーガン、インコーポレイテッド 増大した溶解度を持つ治療活性成分を含む組成物
JP2004518612A (ja) 2000-07-28 2004-06-24 インスパイアー ファーマシューティカルズ，インコーポレイティド インドール誘導体を用いて眼圧を下降させる方法
JP2002161032A (ja) 2000-09-14 2002-06-04 Taisho Pharmaceut Co Ltd 粘膜適用組成物
WO2002024191A1 (fr) 2000-09-20 2002-03-28 Yong Guang Pharmaceutical Co., Ltd. Medicament permettant de traiter et de prevenir la myopie
US20020183279A1 (en) 2001-04-18 2002-12-05 Koichiro Tanaka Pharmaceutical composition containing viscoelastic substance and medication
US20020198209A1 (en) 2001-05-03 2002-12-26 Allergan Sales Inc. Compositions having enhanced pharmacokinetic characteristics
US20030191187A1 (en) 2002-04-01 2003-10-09 Lee Fang Yu Injectable pharmaceutical composition containing a non-steroidal anti-inflammatory drug and method for preparing the same
CN1684701B (zh) * 2002-07-30 2012-10-17 奥默罗斯公司 眼科冲洗液及方法
US7439241B2 (en) 2003-05-27 2008-10-21 Galderma Laboratories, Inc. Compounds, formulations, and methods for treating or preventing rosacea
WO2006069213A1 (en) * 2004-12-22 2006-06-29 Schering Corporation Pharmaceutical formulations
CN101083984B (zh) 2004-12-23 2010-11-10 罗克斯罗制药公司 用于经鼻内投与酮咯酸（ketorolac）的治疗组合物
FR2882930B1 (fr) 2005-03-09 2009-03-27 Walid Katib Nouvelles compositions ophtalmologiques et leur mode d'utilisation
DOP2007000055A (es) * 2006-04-10 2007-10-31 Senosiain S A De C V Lab Composición farmaceutica que comprende un analgésico y vitaminas
US20090258850A1 (en) 2007-08-21 2009-10-15 Frincke James M Stabilized therapeutic compositions and formulations
JP2011503061A (ja) 2007-11-08 2011-01-27 アーシエックス セラピューティックス， インコーポレイテッド 浸透圧活性剤及び血管収縮剤を含む眼けん腫脹の治療及び防止のための組成物
WO2009074853A2 (en) 2007-12-10 2009-06-18 Promed Research Centre Ophthalmic composition comprising phenylephrine
US7842714B2 (en) 2008-03-03 2010-11-30 Allergan, Inc. Ketorolac tromethamine compositions for treating ocular pain
US9192571B2 (en) 2008-03-03 2015-11-24 Allergan, Inc. Ketorolac tromethamine compositions for treating or preventing ocular pain
MX2011009312A (es) * 2009-03-06 2012-02-29 Medimmune Llc Formulaciones de anticuerpos humanizados anti-cd19.
US8277781B2 (en) 2009-03-13 2012-10-02 Luitpold Pharmaceuticals, Inc. Device for intranasal administration
MX2011013061A (es) * 2009-06-05 2012-02-28 Aciex Therapeutics Inc Formulaciones oftalmicas de fluticasona y metodos de uso.
JP2012528888A (ja) 2009-06-05 2012-11-15 アーシエックス セラピューティックス， インコーポレイテッド 眼科用配合剤、その製造方法およびその使用方法
US8680510B2 (en) 2010-06-28 2014-03-25 International Business Machines Corporation Method of forming compound semiconductor
TR201818754T4 (tr) 2010-07-29 2019-01-21 Allergan Inc Koruyucu içermeyen Brimonidin Ve Timolol Çözeltileri
AU2013201465B2 (en) * 2012-10-24 2016-03-03 Rayner Intraocular Lenses Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
TWI809304B (zh) 2014-12-01 2023-07-21 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液

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