KR20170104639A - 디펩티딜 펩티다제 ⅳ 억제제의 용도 - Google Patents

디펩티딜 펩티다제 ⅳ 억제제의 용도 Download PDF

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Publication number
KR20170104639A
KR20170104639A KR1020177024680A KR20177024680A KR20170104639A KR 20170104639 A KR20170104639 A KR 20170104639A KR 1020177024680 A KR1020177024680 A KR 1020177024680A KR 20177024680 A KR20177024680 A KR 20177024680A KR 20170104639 A KR20170104639 A KR 20170104639A
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South Korea
Prior art keywords
disease
heart failure
dpp
pharmaceutical composition
amino
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KR1020177024680A
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English (en)
Korean (ko)
Inventor
리차드 프래틀리
제임스 이. 폴리
토마스 에드워드 허기스
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노파르티스 아게
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Publication of KR20170104639A publication Critical patent/KR20170104639A/ko
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020177024680A 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도 Withdrawn KR20170104639A (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US52056303P 2003-11-17 2003-11-17
US52056203P 2003-11-17 2003-11-17
US60/520,563 2003-11-17
US60/520,562 2003-11-17
US54719104P 2004-02-24 2004-02-24
US54719204P 2004-02-24 2004-02-24
US60/547,192 2004-02-24
US60/547,191 2004-02-24
PCT/EP2004/012990 WO2005049022A2 (en) 2003-11-17 2004-11-16 Use of dipeptidyl peptidase iv inhibitors

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020167036999A Division KR20170005163A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020187012266A Division KR20180050427A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도

Publications (1)

Publication Number Publication Date
KR20170104639A true KR20170104639A (ko) 2017-09-15

Family

ID=34623985

Family Applications (10)

Application Number Title Priority Date Filing Date
KR1020147014776A Withdrawn KR20140089408A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR1020157032295A Ceased KR20150132601A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR1020067009502A Withdrawn KR20060109911A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR1020187012266A Ceased KR20180050427A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR1020137021480A Withdrawn KR20130105741A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR1020127028863A Withdrawn KR20120126133A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR1020167036999A Withdrawn KR20170005163A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR1020127000489A Withdrawn KR20120008093A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR20157002440A Withdrawn KR20150028829A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR1020177024680A Withdrawn KR20170104639A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도

Family Applications Before (9)

Application Number Title Priority Date Filing Date
KR1020147014776A Withdrawn KR20140089408A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR1020157032295A Ceased KR20150132601A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR1020067009502A Withdrawn KR20060109911A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR1020187012266A Ceased KR20180050427A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR1020137021480A Withdrawn KR20130105741A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR1020127028863A Withdrawn KR20120126133A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR1020167036999A Withdrawn KR20170005163A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR1020127000489A Withdrawn KR20120008093A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도
KR20157002440A Withdrawn KR20150028829A (ko) 2003-11-17 2004-11-16 디펩티딜 펩티다제 ⅳ 억제제의 용도

Country Status (9)

Country Link
EP (2) EP1686994A2 (enExample)
JP (6) JP2007511487A (enExample)
KR (10) KR20140089408A (enExample)
CN (1) CN1905876B (enExample)
AU (2) AU2004290897B2 (enExample)
BR (1) BRPI0416628A (enExample)
CA (1) CA2545641A1 (enExample)
MX (1) MXPA06005518A (enExample)
WO (1) WO2005049022A2 (enExample)

Cited By (1)

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