KR20170102381A - （（1ｓ，2ｓ，4ｒ）­4­｛4­〔（1ｓ)­2，3­디하이드로­1ｈ­인덴­1­일아미노〕­7ｈ­피롤로〔2，3­ｄ〕피리미딘­7­일｝­2­하이드록시사이클로펜틸)메틸 설파메이트의 하이드로클로라이드 염 - Google Patents

（（1ｓ，2ｓ，4ｒ）­4­｛4­〔（1ｓ)­2，3­디하이드로­1ｈ­인덴­1­일아미노〕­7ｈ­피롤로〔2，3­ｄ〕피리미딘­7­일｝­2­하이드록시사이클로펜틸)메틸 설파메이트의 하이드로클로라이드 염 Download PDF

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KR20170102381A
KR20170102381A KR1020177024122A KR20177024122A KR20170102381A KR 20170102381 A KR20170102381 A KR 20170102381A KR 1020177024122 A KR1020177024122 A KR 1020177024122A KR 20177024122 A KR20177024122 A KR 20177024122A KR 20170102381 A KR20170102381 A KR 20170102381A
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compound
peaks
angles
thetas
iii
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Korean (ko)
Inventor
이안 지. 아미티지
리누 초프라
마틴 이안 쿠퍼
마리안느 랭스톤
스티븐 피. 랭스톤
스테판 비스코실
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밀레니엄 파머슈티컬스 인코퍼레이티드
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Publication of KR20170102381A publication Critical patent/KR20170102381A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020177024122A 2009-05-14 2010-05-13 （（1ｓ，2ｓ，4ｒ）­4­｛4­〔（1ｓ)­2，3­디하이드로­1ｈ­인덴­1­일아미노〕­7ｈ­피롤로〔2，3­ｄ〕피리미딘­7­일｝­2­하이드록시사이클로펜틸)메틸 설파메이트의 하이드로클로라이드 염 Ceased KR20170102381A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21622109P 2009-05-14 2009-05-14
US61/216,221 2009-05-14
PCT/US2010/001415 WO2010132110A1 (en) 2009-05-14 2010-05-13 Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate

Related Parent Applications (1)

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KR1020117029162A Division KR20120024715A (ko) 2009-05-14 2010-05-13 （（1ｓ，2ｓ，4ｒ）?4?｛4?〔（1ｓ)?2，3?디하이드로?1ｈ?인덴?1?일아미노〕?7ｈ?피롤로〔2，3?ｄ〕피리미딘?7?일｝?2?하이드록시사이클로펜틸)메틸 설파메이트의 하이드로클로라이드 염

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KR20170102381A true KR20170102381A (ko) 2017-09-08

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KR1020177024122A Ceased KR20170102381A (ko) 2009-05-14 2010-05-13 （（1ｓ，2ｓ，4ｒ）­4­｛4­〔（1ｓ)­2，3­디하이드로­1ｈ­인덴­1­일아미노〕­7ｈ­피롤로〔2，3­ｄ〕피리미딘­7­일｝­2­하이드록시사이클로펜틸)메틸 설파메이트의 하이드로클로라이드 염
KR1020117029162A Ceased KR20120024715A (ko) 2009-05-14 2010-05-13 （（1ｓ，2ｓ，4ｒ）?4?｛4?〔（1ｓ)?2，3?디하이드로?1ｈ?인덴?1?일아미노〕?7ｈ?피롤로〔2，3?ｄ〕피리미딘?7?일｝?2?하이드록시사이클로펜틸)메틸 설파메이트의 하이드로클로라이드 염

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KR1020117029162A Ceased KR20120024715A (ko) 2009-05-14 2010-05-13 （（1ｓ，2ｓ，4ｒ）?4?｛4?〔（1ｓ)?2，3?디하이드로?1ｈ?인덴?1?일아미노〕?7ｈ?피롤로〔2，3?ｄ〕피리미딘?7?일｝?2?하이드록시사이클로펜틸)메틸 설파메이트의 하이드로클로라이드 염

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US (2) US9187482B2 (enExample)
EP (2) EP3091020B1 (enExample)
JP (3) JP2012526808A (enExample)
KR (2) KR20170102381A (enExample)
CN (2) CN102421780A (enExample)
AU (1) AU2010248151B2 (enExample)
BR (1) BRPI1012142A2 (enExample)
CA (1) CA2761256C (enExample)
IL (1) IL216201A (enExample)
MX (1) MX2011012108A (enExample)
NZ (2) NZ621128A (enExample)
PE (2) PE20161222A1 (enExample)
PH (1) PH12015501925A1 (enExample)
RU (1) RU2562245C2 (enExample)
SG (2) SG10201402148SA (enExample)
UA (1) UA108986C2 (enExample)
WO (1) WO2010132110A1 (enExample)
ZA (1) ZA201108347B (enExample)

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EP3930720A4 (en) * 2019-02-26 2022-12-28 Millennium Pharmaceuticals, Inc. COMPOUNDS USEFUL AS ADJUVANTS
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MX2011012108A (es) 2011-12-08
RU2011150826A (ru) 2013-06-20
ZA201108347B (en) 2014-05-26
EP3091020A3 (en) 2017-01-11
PE20161222A1 (es) 2016-12-01
NZ621128A (en) 2015-08-28
US20160030432A1 (en) 2016-02-04
EP3091020B1 (en) 2020-12-30
US20110021544A1 (en) 2011-01-27
IL216201A0 (en) 2012-01-31
JP2017105816A (ja) 2017-06-15
IL216201A (en) 2015-11-30
KR20120024715A (ko) 2012-03-14
BRPI1012142A2 (pt) 2016-03-29
EP3091020A2 (en) 2016-11-09
CN102421780A (zh) 2012-04-18
AU2010248151B2 (en) 2016-07-14
NZ596470A (en) 2014-04-30
WO2010132110A1 (en) 2010-11-18
PH12015501925A1 (en) 2018-01-22
US9187482B2 (en) 2015-11-17
JP2012526808A (ja) 2012-11-01
SG10201402148SA (en) 2014-07-30
CN104016987A (zh) 2014-09-03
US10016427B2 (en) 2018-07-10
CA2761256A1 (en) 2010-11-18
RU2562245C2 (ru) 2015-09-10
UA108986C2 (uk) 2015-07-10
EP2430026A1 (en) 2012-03-21
PE20120907A1 (es) 2012-08-18
JP2015096547A (ja) 2015-05-21
SG175929A1 (en) 2011-12-29
US20170000792A9 (en) 2017-01-05
AU2010248151A1 (en) 2011-12-01
CA2761256C (en) 2021-01-05

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