KR20170049604A - Bub1 억제제로서의 벤질 치환된 인다졸 - Google Patents

Bub1 억제제로서의 벤질 치환된 인다졸 Download PDF

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Publication number
KR20170049604A
KR20170049604A KR1020177010425A KR20177010425A KR20170049604A KR 20170049604 A KR20170049604 A KR 20170049604A KR 1020177010425 A KR1020177010425 A KR 1020177010425A KR 20177010425 A KR20177010425 A KR 20177010425A KR 20170049604 A KR20170049604 A KR 20170049604A
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methyl
amino
indazol
alkyl
compound
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Korean (ko)
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안네 맨겔
한스-게오르크 레르첸
만프레트 뫼베스
토마스 뮐러
라르스 배르팍커
마리온 히치콕
아르베트 클레베
요하임 쿠흔케
한스 브림
게르하르트 지마이스터
빌헬름 보네
아모리 에르네스토 페르난데스-몬탈반
옌스 슈로더
우르슐라 묀닝
지몬 홀톤
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바이엘 파마 악티엔게젤샤프트
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Publication of KR20170049604A publication Critical patent/KR20170049604A/ko
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020177010425A 2014-09-19 2015-09-17 Bub1 억제제로서의 벤질 치환된 인다졸 Withdrawn KR20170049604A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP14185604.7 2014-09-19
EP14185604 2014-09-19
EP15176903.1 2015-07-15
EP15176903 2015-07-15
PCT/EP2015/071340 WO2016042084A1 (en) 2014-09-19 2015-09-17 Benzyl substituted indazoles as bub1 inhibitors

Publications (1)

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KR20170049604A true KR20170049604A (ko) 2017-05-10

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KR1020177010425A Withdrawn KR20170049604A (ko) 2014-09-19 2015-09-17 Bub1 억제제로서의 벤질 치환된 인다졸

Country Status (27)

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US (1) US10350206B2 (https=)
EP (1) EP3194379A1 (https=)
JP (1) JP6664385B2 (https=)
KR (1) KR20170049604A (https=)
CN (1) CN107001331A (https=)
AP (1) AP2017009803A0 (https=)
AU (1) AU2015316796A1 (https=)
BR (1) BR112017005444A2 (https=)
CA (1) CA2961589A1 (https=)
CL (1) CL2017000654A1 (https=)
CO (1) CO2017002532A2 (https=)
CR (1) CR20170100A (https=)
CU (1) CU20170029A7 (https=)
DO (1) DOP2017000078A (https=)
EA (1) EA032401B1 (https=)
EC (1) ECSP17016797A (https=)
IL (1) IL251071A0 (https=)
MA (1) MA39484A (https=)
MX (1) MX2017003664A (https=)
NI (1) NI201700034A (https=)
PE (1) PE20170697A1 (https=)
PH (1) PH12017500509A1 (https=)
SG (1) SG11201702082VA (https=)
TN (1) TN2017000092A1 (https=)
TW (1) TW201615636A (https=)
UY (1) UY36311A (https=)
WO (1) WO2016042084A1 (https=)

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CR20200590A (es) 2018-05-04 2021-04-26 Incyte Corp Formas sólidas de un inhibidor de fgfr y procesos para prepararlas
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Publication number Publication date
CO2017002532A2 (es) 2017-07-11
NI201700034A (es) 2017-06-16
US20170273980A1 (en) 2017-09-28
CA2961589A1 (en) 2016-03-24
IL251071A0 (en) 2017-04-30
AU2015316796A1 (en) 2017-03-30
EP3194379A1 (en) 2017-07-26
BR112017005444A2 (pt) 2018-04-24
PE20170697A1 (es) 2017-06-24
TW201615636A (zh) 2016-05-01
EA032401B1 (ru) 2019-05-31
CN107001331A (zh) 2017-08-01
MX2017003664A (es) 2017-07-13
CU20170029A7 (es) 2017-08-08
EA201790649A1 (ru) 2017-09-29
MA39484A (fr) 2016-03-24
WO2016042084A1 (en) 2016-03-24
JP6664385B2 (ja) 2020-03-13
CR20170100A (es) 2017-04-24
AP2017009803A0 (en) 2017-03-31
CL2017000654A1 (es) 2017-12-11
DOP2017000078A (es) 2017-06-30
PH12017500509A1 (en) 2017-08-30
ECSP17016797A (es) 2017-05-31
TN2017000092A1 (en) 2018-07-04
UY36311A (es) 2016-04-29
JP2017530962A (ja) 2017-10-19
US10350206B2 (en) 2019-07-16
SG11201702082VA (en) 2017-04-27

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PA0105 International application

Patent event date: 20170417

Patent event code: PA01051R01D

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