KR20170046180A - 형질감염 중 재배열 (ret) 억제제로서의 신규 화합물 - Google Patents

형질감염 중 재배열 (ret) 억제제로서의 신규 화합물 Download PDF

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KR20170046180A
KR20170046180A KR1020177009244A KR20177009244A KR20170046180A KR 20170046180 A KR20170046180 A KR 20170046180A KR 1020177009244 A KR1020177009244 A KR 1020177009244A KR 20177009244 A KR20177009244 A KR 20177009244A KR 20170046180 A KR20170046180 A KR 20170046180A
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urea
phenyl
alkyl
trifluoromethyl
oxo
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무이 청
마이클 피. 데마르티노
힐러리 쉔크 에이댐
히핑 에이미 관
동희 친
청더 우
젠 공
해영 양
하이유 유
지리우 장
Original Assignee
글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드
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Publication of KR20170046180A publication Critical patent/KR20170046180A/ko
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020177009244A 2014-09-10 2015-09-10 형질감염 중 재배열 (ret) 억제제로서의 신규 화합물 Ceased KR20170046180A (ko)

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Application Number Priority Date Filing Date Title
CNPCT/CN2014/000834 2014-09-10
CN2014000834 2014-09-10
PCT/CN2015/089332 WO2016037578A1 (en) 2014-09-10 2015-09-10 Novel compounds as rearranged during transfection (ret) inhibitors

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KR20170046180A true KR20170046180A (ko) 2017-04-28

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CN (1) CN107250110B (enExample)
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PH12017500454A1 (en) 2017-07-31
US10294236B2 (en) 2019-05-21
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AU2015316438A1 (en) 2017-03-30
US20180099976A1 (en) 2018-04-12
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DOP2017000067A (es) 2017-04-16
ES2819871T3 (es) 2021-04-19
US20170298074A1 (en) 2017-10-19
SG11201701695UA (en) 2017-04-27
US9879021B2 (en) 2018-01-30
MX381233B (es) 2025-03-12
BR112017004897A2 (pt) 2017-12-12
CO2017002378A2 (es) 2017-06-30
UA123084C2 (uk) 2021-02-17
EP3191449B1 (en) 2020-07-01
IL250923A0 (en) 2017-04-30
DK3191449T3 (da) 2020-08-03
EA032030B1 (ru) 2019-03-29
IL250923B (en) 2021-04-29
EP3191449A1 (en) 2017-07-19
JP6538153B2 (ja) 2019-07-03
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CN107250110A (zh) 2017-10-13
EP3191449A4 (en) 2018-04-25
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MY187169A (en) 2021-09-07
WO2016037578A1 (en) 2016-03-17

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