KR20160104740A - 응고 인자 ｖｉｉｉ을 정제하는 방법 - Google Patents

응고 인자 ｖｉｉｉ을 정제하는 방법 Download PDF

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Publication number
KR20160104740A
KR20160104740A KR1020167023450A KR20167023450A KR20160104740A KR 20160104740 A KR20160104740 A KR 20160104740A KR 1020167023450 A KR1020167023450 A KR 1020167023450A KR 20167023450 A KR20167023450 A KR 20167023450A KR 20160104740 A KR20160104740 A KR 20160104740A
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KR
South Korea
Prior art keywords
fviii
resin
buffer
composition
chromatography
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Abandoned
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KR1020167023450A
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English (en)
Korean (ko)
Inventor
카린 보르그발
울리카 에릭손
구스타브 길리암
매츠 예른베르그
스테판 빙게
Original Assignee
옥타파마 아게
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40076764&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20160104740(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 옥타파마 아게 filed Critical 옥타파마 아게
Publication of KR20160104740A publication Critical patent/KR20160104740A/ko
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847—Multimodal interactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
KR1020167023450A 2008-06-24 2009-06-24 응고 인자 ｖｉｉｉ을 정제하는 방법 Abandoned KR20160104740A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12940208P 2008-06-24 2008-06-24
EP08158893.1 2008-06-24
EP08158893 2008-06-24
US61/129,402 2008-06-24
PCT/EP2009/057883 WO2009156430A1 (en) 2008-06-24 2009-06-24 A process of purifying coagulation factor viii

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020107028866A Division KR101700722B1 (ko) 2008-06-24 2009-06-24 응고 인자 ｖｉｉｉ을 정제하는 방법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020177024076A Division KR101804136B1 (ko) 2008-06-24 2009-06-24 응고 인자 ｖｉｉｉ을 정제하는 방법

Publications (1)

Publication Number Publication Date
KR20160104740A true KR20160104740A (ko) 2016-09-05

Family

ID=40076764

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020167023450A Abandoned KR20160104740A (ko) 2008-06-24 2009-06-24 응고 인자 ｖｉｉｉ을 정제하는 방법
KR1020107028866A Active KR101700722B1 (ko) 2008-06-24 2009-06-24 응고 인자 ｖｉｉｉ을 정제하는 방법
KR1020177024076A Active KR101804136B1 (ko) 2008-06-24 2009-06-24 응고 인자 ｖｉｉｉ을 정제하는 방법

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020107028866A Active KR101700722B1 (ko) 2008-06-24 2009-06-24 응고 인자 ｖｉｉｉ을 정제하는 방법
KR1020177024076A Active KR101804136B1 (ko) 2008-06-24 2009-06-24 응고 인자 ｖｉｉｉ을 정제하는 방법

Country Status (19)

Country Link
US (1) US8329871B2 (https=)
EP (2) EP2300497B1 (https=)
JP (1) JP5619738B2 (https=)
KR (3) KR20160104740A (https=)
CN (1) CN102066417B (https=)
AU (1) AU2009264282B2 (https=)
BR (1) BRPI0914695B1 (https=)
CA (1) CA2728047C (https=)
DK (2) DK2300497T3 (https=)
ES (2) ES2391613T3 (https=)
IL (3) IL229583B (https=)
MX (1) MX2010013908A (https=)
PL (1) PL2300497T3 (https=)
PT (1) PT2300497E (https=)
RU (2) RU2698392C2 (https=)
SI (1) SI2300497T1 (https=)
UA (1) UA100901C2 (https=)
WO (1) WO2009156430A1 (https=)
ZA (1) ZA201009162B (https=)

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US20110178019A1 (en) * 2008-09-03 2011-07-21 Brita Rippner New protecting compositions for recombinantly produced factor viii
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EP2553095B1 (en) * 2010-03-30 2016-10-12 Octapharma AG A process for purifying vitamin K dependent proteins such as coagulation factor IX
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JP5640189B2 (ja) 2011-06-17 2014-12-17 学校法人東日本学園 ループスアンチコアグラント検出用血液凝固時間の測定方法
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RU2695428C2 (ru) * 2014-01-20 2019-07-23 Октафарма Аг СПОСОБ ПРОИЗВОДСТВА ФАКТОРА VIII, ИМЕЮЩЕГО УЛУЧШЕННОЕ СООТНОШЕНИЕ FVIII:C/FVIII:Ag
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KR102382402B1 (ko) 2014-02-04 2022-04-01 바이오젠 엠에이 인코포레이티드 번역 후 변형을 강화시키기 위한 통류 방식 양이온 교환 크로마토그래피의 용도
CN104861060A (zh) * 2014-02-21 2015-08-26 神州细胞工程有限公司 一种纯化凝血因子viii的方法
KR20170010750A (ko) 2014-05-29 2017-02-01 에이전시 포 사이언스, 테크놀로지 앤드 리서치 단백질 추출 방법들
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Also Published As

Publication number Publication date
ES2538706T3 (es) 2015-06-23
EP2300497B1 (en) 2012-08-08
AU2009264282A1 (en) 2009-12-30
EP2537862B1 (en) 2015-03-18
ES2391613T3 (es) 2012-11-28
BRPI0914695B1 (pt) 2022-04-19
IL209758A (en) 2014-02-27
BRPI0914695A2 (pt) 2015-10-20
IL229583B (en) 2018-03-29
SI2300497T1 (sl) 2013-02-28
KR20170102065A (ko) 2017-09-06
KR20110038634A (ko) 2011-04-14
RU2567811C2 (ru) 2015-11-10
CA2728047C (en) 2019-07-30
RU2015141849A3 (https=) 2018-12-28
UA100901C2 (ru) 2013-02-11
PT2300497E (pt) 2012-10-30
RU2015141849A (ru) 2018-12-28
CA2728047A1 (en) 2009-12-30
JP5619738B2 (ja) 2014-11-05
JP2011525523A (ja) 2011-09-22
CN102066417A (zh) 2011-05-18
EP2537862A1 (en) 2012-12-26
PL2300497T3 (pl) 2013-02-28
RU2011102437A (ru) 2012-07-27
IL209758A0 (en) 2011-02-28
DK2537862T3 (en) 2015-06-15
IL229583A0 (en) 2014-01-30
CN102066417B (zh) 2015-11-25
RU2698392C2 (ru) 2019-08-26
ZA201009162B (en) 2011-10-26
US8329871B2 (en) 2012-12-11
US20110160435A1 (en) 2011-06-30
MX2010013908A (es) 2011-01-21
AU2009264282B2 (en) 2013-04-18
DK2300497T3 (da) 2012-10-29
WO2009156430A1 (en) 2009-12-30
EP2300497A1 (en) 2011-03-30
KR101804136B1 (ko) 2017-12-04
KR101700722B1 (ko) 2017-01-31

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