KR20150128770A - 티오에스테라아제 및 맞춤형 오일 생산용 세포 - Google Patents

티오에스테라아제 및 맞춤형 오일 생산용 세포 Download PDF

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KR20150128770A
KR20150128770A KR1020157027058A KR20157027058A KR20150128770A KR 20150128770 A KR20150128770 A KR 20150128770A KR 1020157027058 A KR1020157027058 A KR 1020157027058A KR 20157027058 A KR20157027058 A KR 20157027058A KR 20150128770 A KR20150128770 A KR 20150128770A
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죠지 엔. 루덴코
제이슨 카솔라리
스코트 프랭클린
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솔라짐, 인코포레이티드
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Abstract

본 발명은 FatB 클래스의 식물 아실-ACP 티오에스테라아제 유전자들 및 이러한 유전자들에 의해 암호화된 단백질들을 특징으로 한다. 이러한 유전자들은 변경된 지방산 프로파일을 가지고 있는 재조합 숙주 세포들을 구축하는 데에 유용하다. 새로운 유전자들 또는 이전에 확인된 FatB 유전자들이 있는 유지성 미세조류 숙주 세포들이 개시된다. 이러한 미세조류 세포들은 유용한 지방산 프로파일을 나타내는 트리글리세라이드들을 생산한다.

Description

티오에스테라아제 및 맞춤형 오일 생산용 세포{THIOESTERASES AND CELLS FOR PRODUCTION OF TAILORED OILS}
<관련 출원에 대한 상호 참조>
본 출원은 2013년 3월 15일 제출된, 미국 특허 출원 번호 13/837,996의 일부 계속출원으로, 2013년 3월 15일 제출된, 미국 가특허출원 일련번호 61/791,861와 2013년 12월 17일 제출된, 미국 가특허출원 일련번호 61/917,217의 이익을 주장하며, 이들 각각은 그 전체가 본 출원에 참조로써 포함된다.
식물 및 일부 미세조류를 비롯한 특정 유기체들은 지방산 합성을 위하여 별개의 단일 기능 효소들을 이용하는 것을 특징으로 하는 II형 지방산 생합성 경로를 이용한다. 이와 대조적으로, 포유류 및 균류는 단일의, 대형, 다기능 단백질을 이용한다.
II형 지방산 생합성은 전형적으로 두 개의 탄소 단위로 증가하는 아실-ACP(아실기 운반 단백질) 사슬의 연장에 이어, 아실-ACP 티오에스테라아제에 의한 절단을 수반한다. 식물에서는 아실-ACP 티오에스테라아제의 두 가지 주요 클래스가 확인되었다: (i) 올레일-ACP를 올레산염(18:1 지방산)과 ACP로 가수분해하는 경향이 있는 FatA 클래스의 유전자들에 의해 암호화된 것들과 (ii) 상응하는 아실-ACP 분자들로부터 C8-C16 지방산을 유리시키는, FatB 클래스의 유전자들에 의해 암호화된 것들이다.
다양한 식물로부터의 상이한 FatB 유전자들은 상이한 아실 사슬 길이에 대해 특이성을 나타낸다. 그 결과, 상이한 유전자 산물들이 식물 종자들 내에서 상이한 지방산 프로파일을 가져올 것이다. 미국 특허 번호 5,850,022; 5,723,761; 5,639,790; 5,807,893; 5,455,167; 5,654,495; 5,512,482; 5,298,421; 5,667,997; 및 5,344,771; 5,304,481 참조. 최근, 변경된 지방산 프로파일을 나타내는 트리글리세라이드를 생산하고자 FatB 유전자들이 유지성 미세조류 내로 클로닝된 바 있다. WO2010/063032, WO2011/150411, WO2012/106560 및 WO2013/158938 참조.
다양한 양태에서, 본 출원에서 고려된 발명(들)은 다음 구현예들 중 임의의 하나 이상을 포함할 수 있으나, 이에 한정될 필요는 없다:
구현예 1: 조절 요소 및 핵산 구성체를 발현하는 세포에 의해 생산된 오일에서 변경된 지방산 프로파일을 생성하기 위해 이용 가능한 활성 아실-ACP 티오에스테라아제를 발현하는 FatB 유전자를 포함하는 핵산 구성체로서, 이때, FatB 유전자는 표 1a의 클레드 5에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 이러한 서열은 서열 번호 88, 82, 85 및 103 각각과 적어도 94.6% 서열 동일성을 나타내고, 선택적으로는 이러한 오일의 지방산은 C8 및 C10 지방산이 강화되는 것인, 핵산 구성체.
구현예 2: 조절 요소 및 핵산 구성체를 발현하는 세포에 의해 생산된 오일에서 변경된 지방산 프로파일을 생성하기 위해 이용 가능한 활성 아실-ACP 티오에스테라아제를 발현하는 FatB 유전자를 포함하는 핵산 구성체로서, 이때, FatB 유전자는 표 1a의 클레드 1-12 중 하나에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하는 것인, 핵산 구성체.
구현예 3: 구현예 2의 핵산 구성체로서, 이때, FatB 유전자는 표 1a의 클레드 1에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 이러한 서열은 서열 번호 19, 161, 22 및 160 각각과 적어도 85.9% 서열 동일성을 나타내고, 선택적으로는 이러한 오일의 지방산은 C14 및 C16 지방산이 강화되는 것인, 핵산 구성체.
구현예 4: 구현예 2의 핵산 구성체로서, 이때, FatB 유전자는 표 1a의 클레드 2에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 이러한 서열은 서열 번호 134-136, 132, 133, 137, 124, 122, 123, 125 각각과 적어도 89.5% 서열 동일성을 나타내고, 선택적으로는 이러한 오일의 지방산은 C12 및 C14 지방산이 강화되는 것인, 핵산 구성체.
구현예 5: 구현예 2의 핵산 구성체로서, 이때, FatB 유전자는 표 1a의 클레드 3에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 이러한 서열은 서열 번호 126 및 127 각각과 적어도 92.5% 서열 동일성을 나타내고, 선택적으로는 이러한 오일의 지방산은 C12 및 C14 지방산이 강화되는 것인, 핵산 구성체.
구현예 6: 구현예 2의 핵산 구성체로서, 이때, FatB 유전자는 표 1a의 클레드 4에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 이러한 서열은 서열 번호 79와 적어도 83.8% 서열 동일성을 나타내고, 선택적으로는 이러한 오일의 지방산은 C12 및 C14 지방산이 강화되는 것인, 핵산 구성체.
구현예 7: 구현예 2의 핵산 구성체로서, 이때, FatB 유전자는 표 1a의 클레드 6에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 이러한 서열은 서열 번호 111 및 110과 적어도 99.9% 서열 동일성을 나타내고, 선택적으로는 이러한 오일의 지방산은 C10 지방산이 강화되는 것인, 핵산 구성체.
구현예 8: 구현예 2의 핵산 구성체로서, 이때, FatB 유전자는 표 1a의 클레드 7에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 이러한 서열은 서열 번호 73, 106, 185, 172, 171, 173, 174 각각과 적어도 89.5% 서열 동일성을 나타내고, 선택적으로는 이러한 오일의 지방산은 C10 및 C12 지방산이 강화되는 것인, 핵산 구성체.
구현예 9: 구현예 2의 핵산 구성체로서, 이때, FatB 유전자는 표 1a의 클레드 8에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 이러한 서열은 서열 번호 112, 113, 142, 145, 143, 144, 139, 140, 138, 141 각각과 적어도 85.9% 서열 동일성을 나타내고, 선택적으로는 이러한 오일의 지방산은 C12 및 C14 지방산이 강화되는 것인, 핵산 구성체.
구현예 10: 구현예 2의 핵산 구성체로서, 이때, FatB 유전자는 표 1a의 클레드 9에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 이러한 서열은 서열 번호 187-189 각각과 적어도 83.8% 서열 동일성을 나타내고, 선택적으로는 이러한 오일의 지방산은 C12 및 C14 지방산이 강화되는 것인, 핵산 구성체.
구현예 11: 구현예 2의 핵산 구성체로서, 이때, FatB 유전자는 표 1a의 클레드 10에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 이러한 서열은 서열 번호 147, 149, 146, 150, 152, 151, 148, 154, 156, 155, 157, 108, 75, 190, 191 및 192 각각과 적어도 95.9% 서열 동일성을 나타내고, 선택적으로는 이러한 오일의 지방산은 C14 및 C16 지방산이 강화되는 것인, 핵산 구성체.
구현예 12: 구현예 2의 핵산 구성체로서, 이때, FatB 유전자는 표 1a의 클레드 11에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 이러한 서열은 서열 번호 121과 적어도 88.7% 서열 동일성을 나타내고, 선택적으로는 이러한 오일의 지방산은 C14 및 C16 지방산이 강화되는 것인, 핵산 구성체.
구현예 13: 구현예 2의 핵산 구성체로서, 이때, FatB 유전자는 표 1a의 클레드 12에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 이러한 서열은 서열 번호 129 및 186과 적어도 72.8% 서열 동일성을 나타내고, 선택적으로는 이러한 오일의 지방산은 C16 지방산이 강화되는 것인, 핵산 구성체.
구현예 14: 분리된 핵산 또는 핵산을 포함하는 재조합 DNA 구성체로서, 이때, 핵산은 서열 번호 2, 3, 5, 6, 8, 9, 11, 12, 14, 15, 17, 18, 20, 21, 23, 24, 26, 27, 29, 30, 32, 33, 35, 36, 38, 39, 41, 42, 44, 45, 47, 48, 50, 51, 53, 54, 56, 57, 59, 60, 62, 63, 65, 66, 68, 69, 71, 72, 74, 76, 78, 80, 81, 83, 84, 86, 87, 89, 90, 92, 93, 95, 96, 98, 99, 101, 102, 104, 105, 107, 109 또는 유전자 암호의 축중(degeneracy)에 의한 임의의 균등한 서열들 중 임의의 것과 적어도 80% 서열 동일성을 나타내는 것인, 분리된 핵산 또는 핵산을 포함하는 재조합 DNA 구성체.
구현예 15: 단백질을 암호화하는 분리된 핵산, 또는 서열 번호 1, 4, 7, 10, 13, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 73, 75, 77, 79, 82, 85, 88, 91, 94, 97, 100, 103, 106, 108, 110-192 중 어느 것과 적어도 80% 서열 동일성을 나타내는 단백질 또는 아실-ACP 티오에스테라아제 활성을 가지고 있는 이의 단편을 발현하는 숙주 세포.
구현예 16: 구현예 15의 분리된 핵산으로, 이때, 단백질은 그 서열을 포함하는 재조합 세포에 의해 생성된 오일의 지방산 프로파일을 변경하기 위해 이용 가능한 아실-ACP 티오에스테라아제 활성이 있는 것인, 분리된 핵산.
구현예 17: 변경된 지방산 프로파일을 생성하는 재조합 세포를 생산하는 방법으로, 구현예 1-3 중 임의의 것에 따른 핵산으로 세포를 형질전환하는 것을 포함하는 방법.
구현예 18: 구현예 17의 방법에 의해 생산된 숙주 세포.
구현예 19: 구현예 18의 숙주 세포로서, 이때, 숙주 세포는 식물 세포, 미생물 세포 및 미세조류 세포로부터 선택되는 것인 숙주 세포.
구현예 20: 오일 또는 오일 유래 생성물을 생산하는 방법으로, 이러한 방법은 구현예 5 또는 6의 숙주 세포를 배양하는 것 및 그에 의해 생산된 오일을 추출하는 것을 포함하며, 선택적으로, 이때, 배양은 당에서의 종속 영양성 성장인 것인, 방법.
구현예 21: 구현예 20의 방법으로, 이러한 오일로부터 지방산, 연료, 화학물질, 또는 기타 오일 유래 생성물을 생산하는 것을 더 포함하는 방법.
구현예 22: 구현예 20의 방법에 의해 생산된 오일로서, 선택적으로 적어도 20%의 C8, C10, C12, C14 또는 C16 지방산을 포함하는 지방산 프로파일을 나타내는 오일.
구현예 23: 구현예 21의 방법에 의해 생산된 오일 유래 생성물.
구현예 24: 구현예 23의 오일로서, 이때, 이러한 오일은 미세조류에 의해 생산되고, 선택적으로 C24-알파 스테롤이 없는 오일.
정의
핵산에 대해 사용된 용어 "분리된"은 자연적으로 발생하는 핵산에 전형적으로 존재하는 적어도 하나의 다른 구성요소가 없는 핵산을 지칭한다. 따라서, 자연적으로 발생하는 핵산은 이러한 핵산에 자연적으로 발생하는 적어도 하나의 다른 구성요소로부터 정제되었을 경우, 분리된 것이다.
"천연 오일" 또는 "천연 지방"은 유기체로부터 얻어진 대부분의 트리글리세라이드 오일을 의미하며, 여기서 이러한 오일은 실질적으로 트리글리세라이드의 지방산 프로파일을 변경하기 위하여 또 다른 천연 또는 합성 오일과의 혼합 또는 분별을 겪지 않았다. 특별한 위치특이성의 트리글리세라이드들을 포함하는 오일과 관련하여, 천연 오일 또는 천연 지방은 그러한 위치특이성 트리글리세라이드 프로파일을 얻기 위하여 에스테르 교환 반응 또는 기타 합성 과정을 겪지 않았고, 오히려 세포 또는 세포 군집에 의해, 자연적으로 위치특이성이 생성된다. 천연 오일 또는 천연 지방과 관련하여, 그리고 본 개시 전반에 걸쳐 일반적으로 사용된 바와 같이, 용어 오일 및 지방은 달리 언급된 경우를 제외하고는 상호 교환적으로 이용된다. 따라서, "오일" 또는 "지방"은 물질의 구성 및 기타 조건에 따라 실온에서 액체, 고체 또는 부분적으로 고체일 수 있다. 여기서, 용어 "분별"은 유기체에 의해 생성된, 그러나 달성된 프로파일에 비해, 그 지방산 프로파일을 바꾸는 방식으로 오일로부터 물질을 제거하는 것을 의미한다. 용어 "천연 오일" 및 "천연 지방"은 유기체로부터 얻어진 그러한 오일들을 포괄하며, 여기서 이러한 오일은 실질적으로 그것의 트리글리세라이드 프로파일을 바꾸지 않는, 정제, 표백 및/또는 탈검을 포함하는, 최소한의 가공을 겪었다. 또한, 천연 오일은 "에스테르 교환 반응되지 않은 천연 오일"일 수 있는데, 이는 지방산들이 그것들의 아실 결합에서 글리세롤로 재분배되었고 지방산들이 본질적으로 유기체로부터 회수될 때와 동일한 배열로 남아 있는 과정을 이러한 천연 오일이 겪지 않았음을 의미한다.
"외인성 유전자"는 (예컨대, 형질전환/형질감염에 의해) 세포 내로 도입된 RNA 및/또는 단백질의 발현을 위해 부호화되는 핵산을 의미할 것이며, "이식유전자"라고도 지칭된다. 외인성 유전자를 포함하는 세포는 추가적인 외인성 유전자(들)가 도입될 수 있는, 재조합 세포라 지칭될 수 있다. 외인성 유전자는 형질전환되는 세포에 비해, 상이한 종으로부터(따라서 이종), 또는 동일한 종으로부터(따라서 동종) 유래할 수 있다. 따라서, 외인성 유전자는 이러한 세포의 게놈에서 상이한 위치를 차지하는 상동 유전자를 포함할 수 있거나, 이러한 유전자의 내생성 카피에 대해, 상이한 제어하에 있다. 외인성 유전자는 세포에서 둘 이상의 카피로 존재할 수 있다. 외인성 유전자는 세포 내에서, 예를 들어, 게놈으로의 삽입물(핵 또는 색소체)로서 또는 에피솜 분자로서, 유지될 수 있다.
"지방산"은 유리 지방산, 지방산 염, 또는 글리세롤지질 내의 지방 아실 모이어티를 의미할 것이다. 글리세롤지질의 지방 아실 기는 카르복시산, 또는 트리글리세라이드가 가수분해되거나 비누화될 때 생성되는 카르복시산의 음이온의 측면에서 기술될 수 있다.
"미세조류"는 엽록체 또는 기타 색소체를 함유하며, 선택적으로 광합성을 수행할 수 있는 미생물 유기체, 또는 광합성을 수행할 수 있는 원핵 미생물 유기체이다. 미세조류에는 고정된 탄소원을 에너지로서 대사할 수 없는 절대적인 광합성 독립 영양생물뿐만 아니라, 오로지 고정된 탄소원으로만 살 수 있는 종속 영양생물이 포함된다. 미세조류에는 클라미도모나스와 같은, 세포 분열 직후에 자매 세포로부터 분리되는 단일 세포 유기체뿐만 아니라, 예를 들어, 두 개의 구별되는 세포 유형의, 단순한 다세포 광합성 미생물인 볼복스와 같은 미생물이 포함된다. 미세조류에는 클로렐라, 두날리엘라 및 프로토테카와 같은 세포들이 포함된다. 또한, 미세조류에는 아그메넬룸, 아나베나 및 피로보트리스와 같은, 세포-세포 부착을 나타내는, 기타 미생물 광합성 유기체가 포함된다. 미세조류는 일부 와편모충 조류 종 및 프로토테카 속의 종과 같은, 광합성을 수행하는 능력을 상실한 절대적인 종속 영양성 미생물도 포함한다.
"유지성(oleaginous)" 세포는 자연적으로 또는 재조합 또는 전통적인 균주 개량을 통해, 건조 세포 중량으로, 적어도 20%의 지질을 생산할 수 있는 세포이다. "유지성 미생물"은 유지성인 미세조류를 포함하는 미생물이다.
둘 이상의 아미노산 또는 핵산 서열들의 맥락에서 용어 "서열 동일성 백분율"은 동일하거나, 서열 비교 알고리즘을 이용해 측정된 바와 같은, 또는 육안 검사에 의해, 최대 대응을 위해 비교 및 정렬하였을 때, 소정의 백분율의 동일한 아미노산 잔기들 또는 뉴클레오티드들을 가지고 있는, 둘 이상의 서열들 또는 하위 서열들을 지칭한다. 뉴클레오티드 또는 아미노산 동일성 백분율을 결정하기 위한 서열 비교를 위해, 전형적으로는 하나의 서열이 참조 서열로 작용하고, 이것과 시험 서열들을 비교한다. 서열 비교 알고리즘을 이용할 때, 시험 및 참조 서열들을 컴퓨터에 입력하고, 필요한 경우, 하위 서열 좌표들을 지정하고, 서열 알고리즘 프로그램 매개변수들을 지정한다. 그런 다음, 서열 비교 알고리즘은 지정된 프로그램 매개변수들을 기초로, 참조 서열에 대한, 시험 서열(들)을 대상으로 서열 동일성 백분율을 계산한다. 비교를 위한 최적의 서열 정렬은 초기 설정 매개변수들로 설정된 NCBI BLAST 소프트웨어(ncbi.nlm.nih.gov/BLAST/)를 이용하여 수행될 수 있다. 예를 들어, 두 개의 핵산 서열들을 비교하기 위해, 다음과 같은 초기 설정 매개변수들로 설정된 "BLAST 2 시퀀스" 툴 버전 2.0.12(2000년 4월 21일)과 함께 블라스트엔(blastn)을 이용할 수 있다: 행렬: BLOSUM62; 매치에 대한 보상: 1; 미스매치에 대한 벌점: -2; 오픈 갭(open gap): 5와 익스텐션 갭(extension gap): 2의 벌점; 갭 x 드롭 오프: 50; 익스펙트(expect): 10; 단어 크기: 11; 필터: 온(on). 두 아미노산 서열들의 쌍별 비교를 위해, 블라스트피(blastp)와 함께, 예를 들어 다음과 같은 초기 설정 매개변수들로 설정된, "BLAST 2 시퀀스" 툴 버전 2.0.12(2000년 4월 21일)을 이용할 수 있다: 행렬: BLOSUM62; 오픈 갭: 11과 익스텐션 갭: 1의 벌점; 갭 x 드롭 오프 50; 익스펙트: 10; 단어 크기: 3; 필터: 온.
천연 오일과 관련하여, "프로파일"은 오일 내에서 특별한 종 또는 트리글리세라이드 또는 지방 아실 기들의 분포이다. "지방산 프로파일"은 글리세롤 백본에 대한 결합을 참조하지 않은, 오일의 트리글리세라이드 내의 지방 아실 기의 분포이다. 지방산 프로파일은 전형적으로는 지방산 메틸 에스테르(FAME)로의 전환에 이어, 불꽃 이온화 검출(FID)을 이용한 기체 크로마토그래피(GC)에 의해 결정된다. 지방산 프로파일은 그 지방산에 대한 곡선 하의 면적으로부터 결정된 총 지방산 신호 내의 지방산의 하나 이상의 백분율로서 표현될 수 있다. FAME-GC-FID 측정값은 지방산들의 중량 백분율과 비슷하다.
본 출원에 사용된 바와 같이, 오일은, 비 강화 오일에 비해, 오일 내의 그 지방산의 질량이 적어도 10% 증가하는 경우, 하나 이상의 특정 지방산들이 "강화된" 것이라 한다. 예를 들어, 본 출원에 기술된 이종의 FatB 유전자를 발현하는 세포의 경우, 이러한 세포에 의해 생산된 오일은 오일 내의 예컨대, C8 및 C16 지방산의 질량이 이종의 FatB 유전자를 발현하지 않는 동일한 유형의 세포에 의해 생산된 오일(예컨대, 야생형 오일)에서보다 적어도 10% 더 큰 경우, C8 및 C16 지방산이 강화된 것이라고 일컬어진다.
"재조합"은 외인성 핵산의 도입 또는 본래의 핵산의 변화로 인해 변경된 세포, 핵산, 단백질 또는 벡터이다. 따라서, 예컨대, 재조합 (숙주) 세포는 세포의 본래의(비 재조합) 형태 내에서 발견되지 않는 유전자들을 발현할 수 있거나, 비 재조합 세포에 의해 발현되는 유전자들과는 상이한 고유한 유전자들을 발현할 수 있다. 재조합 세포들은 돌연변이, 녹아웃, 안티센스, 간섭 RNA(RNAi) 또는 세포에서 활성 유전자 생성물의 수준을 감소시키는 dsRNA와 같은, 유전자 생성물 또는 억제 요소들을 부호화하는 재조합 핵산들을 제한 없이 포함할 수 있다. "재조합 핵산"은 화학적 합성을 이용하여, 예컨대, 중합효소, 연결효소, 핵산 말단 가수분해효소 및 핵산 내부 가수분해효소를 이용하여, 핵산의 조작에 의해, 일반적으로, 시험관 내에서 본래 형성된 핵산이거나, 그렇지 않으면 자연계에서 보통 발견되지 않는 형태이다. 재조합 핵산들은 예를 들어, 둘 이상의 핵산들을 이용 가능한 연관에 위치시키기 위해 생산될 수 있다. 따라서, 분리된 핵산, 또는 자연계에서는 보통 연결되지 않는 DNA 분자들을 연결함으로써 핵에 의해 시험관 내에서 형성된 발현 벡터는 모두 본 발명의 목적을 위해 재조합인 것으로 간주된다. 또한, 재조합 핵산들은 다른 방법으로, 예컨대, 화학적 DNA 합성을 이용하여, 생산될 수 있다. 일단 재조합 핵산이 제조되어 숙주 세포 또는 유기체 내로 도입되면, 그것은 숙주 세포의 생체 내 세포 기구를 이용하여 복제할 수 있다. 그러나 이러한 핵산들은, 일단 재조합으로 생산되면, 후속적으로 세포 내에서 복제되지만, 여전히 본 발명의 목적을 위해 재조합인 것으로 간주된다. 마찬가지로, "재조합 단백질"은 재조합 기법을 이용하여, 즉, 재조합 핵산의 발현을 통해, 제조된 단백질이다.
본 발명의 구현예들은 식물로부터 분리된 FatB 유전자들의 이용에 관한 것으로, 이러한 유전자들은 재조합 세포에 의해 생산된 오일의 지방산 프로파일을 바꾸기 위하여 숙주 세포 내에서 발현될 수 있다. 지방산 프로파일을 바꾸는 능력에 대해 유전자들을 스크리닝하고자 미세조류인 프로토테카 모리포르미스(Prototheca moriformis)를 이용하였지만, 이러한 유전자들은 광범위한 숙주 세포에서 유용하다. 예를 들어, 이러한 유전자들은 세균, 기타 미세조류 또는 고등 식물에서 발현될 수 있다. 이러한 유전자들은 미국 특허 번호 5,850,022; 5,723,761; 5,639,790; 5,807,893; 5,455,167; 5,654,495; 5,512,482; 5,298,421; 5,667,997; 5,344,771; 및 5,304,481의 방법들에 따라 고등 식물에서 발현될 수 있다. 지방산들은 합성에 의해 또는 생합성에 의해 트리글리세라이드, 지방 알데히드, 지방 알코올 및 기타 함유화학물질들로 더 전환될 수 있다.
특정 구현예에서, 트리글리세라이드는 신규한 FatB 유전자를 발현하는 숙주 세포에 의해 생산된다. 트리글리세라이드를 함유하는 천연 오일이 이러한 숙주 세포로부터 회수될 수 있다. 이러한 천연 오일은 정제, 탈검, 표백 및/또는 탈취될 수 있다. 이러한 오일은, 그 천연 형태 또는 가공된 형태로, 식품, 화학물질, 연료, 화장품, 플라스틱 및 기타 용도에 이용될 수 있다. 다른 구현예에서, FatB 유전자는 신규성이 없을 수 있지만, 미세조류에서 이러한 유전자의 발현은 신규성이 있다.
이러한 유전자들은 숙주 세포에서 발현 또는 재조합을 위한 플라스미드 또는 기타 벡터들을 포함하는 다양한 유전자 구성체에서 이용될 수 있다. 이러한 유전자들은 표적 숙주 세포에서의 발현을 위해 코돈 최적화될 수 있다. 이러한 유전자들에 의해 생산된 단백질들은 생체 내에서 또는 정제된 형태로 이용될 수 있다.
예를 들어, 이러한 유전자는 이용 가능하게 연결된 프로모터 및 5' UTR을 포함하는 발현 벡터에서 제조될 수 있다. 색소체 세포가 숙주로 이용되는 경우, 적절하게 활성이 있는 색소체를 표적으로 하는 펩티드는 아래 실시예에서와 같이 FATB 유전자에 융합될 수 있다. 일반적으로, 새롭게 식별된 FATB 유전자들의 경우, N 말단에 색소체 전이 펩티드를 구성하는 대략 50개의 아미노산이 있으며, 이들에게는 효소를 엽록체로 운반할 책임이 있다. 아래 실시예에서, 이러한 전이 펩티드는 효소를 이러한 세포들의 색소체로 전달하기 위하여 프로토테카 모리포르미스 숙주 세포에서 효과적인 38개의 아미노산 서열로 교체된다. 따라서, 본 발명은 주어진 숙주 세포에서 효소 활성을 최적화하기 위하여 결실 및 융합 단백질을 고려한다. 예를 들어, 숙주 또는 관련된 종으로부터의 전이 펩티드가 본 출원에 기술된 새롭게 발견된 식물 유전자들의 그것을 대신하여 이용될 수 있다.
선택 가능한 마커 유전자가 형질전환된 세포 분리를 돕기 위하여 벡터에 포함될 수 있다. 미세조류에서 유용한 선택 가능한 마커들의 예로는 수크로오스 전환효소 및 항생제 저항성 유전자들을 포함한다.
또한, 개시된 이러한 유전자들은 식물 또는 기타 유기체에서 상보적인 유전자들을 억제하기 위하여 안티센스 또는 억제 RNA(예컨대, RNAi 또는 헤어핀 RNA)를 제조하는 데에 이용될 수 있다.
세포에서 원하는 지방산 프로파일을 생성하는 데에 유용한 것으로 밝혀진 FatB 유전자들을 아래 표 1에 요약하여 나타내었다. 서열 번호 1-109의 서열을 가지고 있는 핵산 또는 단백질들은 재조합 세포의 지방산 프로파일을 바꾸는 데에 이용될 수 있다. 변이형의 핵산들도 이용될 수 있다. 예컨대, 서열 번호 2, 3, 5, 6, 8, 9, 11, 12, 14, 15, 17, 18, 20, 21, 23, 24, 26, 27, 29, 30, 32, 33, 35, 36, 38, 39, 41, 42, 44, 45, 47, 48, 50, 51, 53, 54, 56, 57, 59, 60, 62, 63, 65, 66, 68, 69, 71, 72, 74, 76, 78, 80, 81, 83, 84, 86, 87, 89, 90, 92, 93, 95, 96, 98, 99, 101, 102, 104, 105, 107 또는 109와 적어도 70, 80, 85, 90, 95, 96, 97, 98 또는 99% 서열 동일성을 나타내는 변이형들이 이용될 수 있다. 다양한 숙주 유기체를 위한 유전자의 코돈 최적화는, 유전자 단편들을 이용하는 것과 마찬가지로, 고려된다. 프로토테카 균주 및 클로렐라 프로토테코이드에 대해 바람직한 코돈을 각각 아래 표 2과 표 3에 나타내었다. 쿠페아 라이티(Cuphea wrightii)를 위한 코돈 활용은 표 3a에 나타내었다. 아라비돕시스(Arabidopsis)를 위한 코돈 활용은 표 3b에 나타내었다. 예를 들어, 각 아미노산에 대하여 가장 바람직한 코돈이 선택될 수 있다. 미세조류 및 고등 식물을 포함하는 기타 유기체에 대한 코돈 표는 당해 분야에 공지되어 있다. 일부 구현예에서, 첫 번째 및/또는 두 번째로 가장 바람직한 프로토테카 코돈이 코돈 최적화를 위해 이용된다. 특정 구현예에서, 아래 서열 목록에 함유된 신규한 아미노산 서열들은 표 2 내지 표 3b에 기술된 프로토테카, 클로렐라, 쿠페아 라이티 또는 아라비돕시스에서의 가장 바람직한 코돈 활용에 따른 핵산 서열들, 또는 이들 유래된 핵산 서열들과 적어도 70, 80, 85, 90, 95, 96, 97, 98 또는 99% 서열 동일성을 나타내는 핵산 서열들로 전환된다.
본 발명의 구현예들에는, 서열 번호 1, 4, 7, 10, 13, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 73, 75, 77, 79, 82, 85, 88, 91, 94, 97, 100, 103, 106, 108, 또는 110-192 중 어느 것을 나타내는 단백질 또는 이러한 단백질을 암호화하는 핵산이 있다. 일 구현예에는, 서열 번호 1, 4, 7, 10, 13, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 73, 75, 77, 79, 82, 85, 88, 91, 94, 97, 100, 103, 106, 108, 또는 110-192 중 어느 것과 적어도 70, 75, 80, 85, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 또는 100% 서열 동일성을 나타내는 단백질 또는 이러한 단백질을 암호화하는 핵산이 있다. 일부 구현예에서, 본 발명은 (단백질 또는 핵산 변이형들의 단편들을 포함하는) 위에 기술된 단백질 또는 핵산들 중 임의의 것의 단편을 포괄하며, 이때, 이러한 단백질 단편은 아실-ACP 티오에스테라아제 활성을 나타내거나, 이러한 핵산 단편은 이러한 단백질 단편을 암호화한다. 다른 구현예에서, 이러한 단편은 특별한 기능을 매개하는 아실-ACP 티오에스테라아제의 도메인, 예컨대, 특이성 결정 도메인을 포함한다. 예시적인 단편들이 C 말단 및/또는 N 말단 절단에 의해 생성될 수 있으며, 본 출원에 개시된 전체 길이 서열들의 적어도 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 또는 99%를 포함한다.
일부 구현예에서, 위에 논의된 핵산 또는 단백질들의 변이형에 대한 서열 동일성 백분율은 참조 서열로서 전체 길이의 핵산 서열(예컨대, 서열 번호 2, 3, 5, 6, 8, 9, 11, 12, 14, 15, 17, 18, 20, 21, 23, 24, 26, 27, 29, 30, 32, 33, 35, 36, 38, 39, 41, 42, 44, 45, 47, 48, 50, 51, 53, 54, 56, 57, 59, 60, 62, 63, 65, 66, 68, 69, 71, 72, 74, 76, 78, 80, 81, 83, 84, 86, 87, 89, 90, 92, 93, 95, 96, 98, 99, 101, 102, 104, 105, 107 또는 109 중 하나) 또는 전체 길이의 아미노산 서열(예컨대, 서열 번호 1, 4, 7, 10, 13, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 73, 75, 77, 79, 82, 85, 88, 91, 94, 97, 100, 103, 106, 108, 또는 110-192 중 하나)를 이용하며, 전체 길이의 시험 서열을 이러한 참조 서열과 비교함으로써 계산할 수 있다. 단편과 관련된 일부 구현예에서, 핵산 또는 단백질 단편들의 변이형에 대한 서열 동일성 백분율을 이러한 단편의 전체 길이에 대해 계산할 수 있다.
이러한 핵산들은 분리된 형태, 또는 벡터 또는 기타 구성체, 염색체 또는 숙주 세포의 일부분일 수 있다. 전체 길이의 유전자 (및 단백질)이 필요하지 않은 여러 사례가 있음이 밝혀졌다. 예를 들어, N 말단의 소수성 도메인(전형적으로 LPDW로 시작하는 18개의 아미노산 도메인)의 일부 또는 전부의 결실은 여전히 기능적인 유전자를 가져온다. 또한, 표 1의 유전자들의 특이성 결정 부위의 기타 아실-ACP 티오에스테라아제들의 촉매 도메인과의 융합은 기능적인 유전자들을 생성할 수 있다. 따라서, 일부 구현예에서, 본 발명은 각각 이종의 아실-ACP 티오에스테라아제 핵산 또는 아미노산 서열들에 융합된 개시된 핵산 또는 아미노산들의 기능적 단편들(예컨대, 특이성 결정 부위)을 포괄한다.
[표 1]
본 발명의 구현예들에 따른 FatB 유전자들
Figure pct00001
Figure pct00002
Figure pct00003
일부 구현예에서, 숙주 세포(예컨대, 식물 또는 미세조류 세포)는 표 1a의 클레드 1-12 중 하나에 속하는 재조합 FATB 단백질을 생산하기 위하여 형질전환된다. 이들 클레드는 서열 정렬 및 프로토테카에서 발현될 때 지방산 프로파일의 변화 관찰에 의해 결정되었다. 실시예 5 참조. FATB 아미노산 서열은 표 1a에 열거된 그 클레드에서 각각의 서열의 x% 아미노산 서열 동일성 범위에 속할 수 있는데, 여기서 x는 역시 표 1a에 열거된, 제1, 제2 또는 제3의 절단값이다.
[표 1a]
신규한 FatB 유전자들의 클레드로의 분류
Figure pct00004
Figure pct00005
Figure pct00006
[표 2]
프로토테카 균주에서 바람직한 코돈 활용
Figure pct00007
Figure pct00008
[표 3]
클로렐라 프로토테코이드에서 바람직한 코돈 활용
Figure pct00009
[표 3a]
Figure pct00010
[표 3b]
Figure pct00011
숙주 세포
숙주 세포는 단일 세포(예컨대, 미세조류, 세균, 효모) 또는 식물 또는 균류와 같은 다세포 유기체의 일부분일 수 있다. 식물에서 Fatb 유전자들을 발현시키는 방법은 5,850,022; 5,723,761; 5,639,790; 5,807,893; 5,455,167; 5,654,495; 5,512,482; 5,298,421; 5,667,997; 및 5,344,771; 5,304,481에 제공되어 있고, 또는 식물 유전공학에 일반적으로 공지된 기타 기법들을 이용하여 달성될 수 있다. 녹조류의 미생물을 포함하는 유지성 미생물의 공학 기술은 WO2010/063032, WO2011,150411, 및 WO2012/106560에, 그리고 아래 실시예에 개시되어 있다.
유지성 숙주 세포의 예로는 유지성 조류의 세포들과 같은 색소체의 유지성 세포들을 포함하는, II형 지방산 생합성 경로를 가지고 있는, 식물 세포 및 미생물 세포를 포함한다. 미세조류 세포의 구체적인 예로는 녹조식물 문, 트레보욱시아 강, 클로렐라 목, 또는 클로렐라 과의 종속 영양성 또는 절대 종속 영양성 미세조류를 포함한다. 유지성 미세조류의 예는 공개된 PCT 특허 출원 WO2008/151149, WO2010/06032, WO2011/150410 및 WO2011/150411에 제공되어 있으며, 절대 종속 영양생물을 포함하는 속인 클로렐라 및 프로토테카 종을 포함한다. 유지성 세포들은, 예를 들어, 세포 중량 기준, 25, 30, 40, 50, 60, 70, 80, 85, 또는 약 90% 오일 ±5%를 생산할 능력이 있을 수 있다. 선택적으로, 생산된 오일들은 DHA 또는 EPA 지방산이 낮을 수 있다. 예를 들어, 이러한 오일들은 5%, 2%, 또는 1% 미만의 DHA 및/또는 EPA를 포함할 수 있다. 위에 언급된 공개문헌들은 그러한 세포들을 배양하고, 특히, 미세조류 세포들로부터, 오일을 추출하는 방법들도 개시하고 있다. 그러한 방법들은 본 출원에 개시된 세포들에 적용 가능하며, 이러한 교시를 위해 본 출원에 참조로써 포함된다. 미세조류 세포들이 이용될 때, 그것들은 (절대 종속영양생물이 아닌 한) 독립 영양적으로, 또는 당(예컨대, 글루코오스, 프룩토오스 및/또는 수크로오스)을 이용하여 암소에서 배양될 수 있다. 본 출원에 기술된 구현예들 중 임의의 구현예에서, 이러한 세포들이 수크로오스 공급원료로부터 오일을 생산할 수 있도록 이러한 세포들은 외인성 전환효소 유전자를 포함하는 종속영양 세포일 수 있다. 대안적으로, 또는 추가적으로, 이러한 세포들은 셀룰로오스 공급원료로부터 자일로오스를 대사할 수 있다. 예를 들어, 이러한 세포들은 활성 자일로오스 수송체, 자일룰로스-5-인산 수송체, 자일로오스 이성화효소, 자일룰로키나아제, 자일리톨 탈수소효소 및 자일로오스 환원효소를 암호화하는 것들과 같은, 하나 이상의 자일로오스 대사 유전자들을 발현하도록 유전적으로 조작될 수 있다. 2012년 11월 15일 공개된 WO2012/154626, "GENETICALLY ENGINEERED MICROORGANISMS THAT METABOLIZE XYLOSE" 참조.
오일 및 관련 생성물
이러한 유지성 세포들은 지방산 생합성 효소들을 암호화하는 하나 이상의 외인성 유전자들을 발현한다. 그 결과, 일부 구현예들은 비 식물 또는 비 종자유로부터 얻을 수 있는 것이 아니거나, 전혀 얻을 수 없는 천연 오일을 특징으로 한다.
이러한 유지성 세포들은 저장 오일을 생산하는데, 이는 주로 트리아실글리세라이드이고, 세포의 저장체에 저장될 수 있다. 미정제 오일은 이러한 세포들을 파괴하고 오일을 분리하여 세포로부터 얻을 수 있다. WO2008/151149, WO2010/06032, WO2011/150410 및 WO2011/1504는 종속 영양성 배양 및 오일 분리 기법을 개시하고 있다. 예를 들어, 이러한 세포를 배양하고, 건조시키고, 압착하여 오일을 얻을 수 있다. 생산된 오일을 당해 분야에 공지된 바와 같이, 또는 WO2010/120939에 기술된 바와 같이, 정제하고, 표백하고, 탈취(RBD)할 수 있다. 미정제 또는 RBD 오일은 다양한 식품, 화학물질 및 산업용 제품 또는 공정에 이용될 수 있다. 오일 회수 후, 가치 있는 잔류 바이오매스가 남는다. 잔류 바이오매스의 용도로는 종이, 플라스틱, 흡수제, 흡착제의 생산, 동물 사료로서, 인간 영양용, 또는 비료용을 포함한다.
트리글리세라이드(또는 "트리아실글리세라이드" 또는 "TAG"라 지칭됨) 세포 오일의 지방산 프로파일이 여기에 주어지는 경우, 이는 인지질이 제거된 조건하에서 또는 인지질의 지방산에 실질적으로 둔감한 분석 방법으로(예컨대, 크로마토그래피 및 질량 분광분석법을 이용하여) 분석된 세포로부터 추출된 저장 오일의 분별되지 않은 샘플을 지칭하는 것으로 이해될 것이다. 이러한 오일은 인지질, 유리 지방산 및 악취는 제거하지만, 오일 내의 트리글리세라이드의 지방산 프로파일에는 적거나 무시할 만한 변화만을 가지도록 하기 위해서 RBD 공정을 거칠 수 있다. 이러한 세포들은 유지성이므로, 일부 사례에서 저장 오일은 세포 내에서 모든 TAG의 대부분을 구성할 것이다.
안정적인 탄소 동위원소 값 δ13C는 표준물질(예컨대, 미국 사우스캐롤라이나 주의 피디층(Peedee formation)으로부터의 벨렘나이트 아메리카나(Belemnite americana)의 화석 골격의 탄산염인 PDB)에 대해 13C/12C의 비율을 표현한 것이다. 이러한 오일의 안정적인 탄소 동위원소 값 δ13C(0/00)은 사용된 공급원료의 δ13C 값과 관련이 있을 수 있다. 일부 구현예들에서, 이러한 오일은 옥수수 또는 사탕수수와 같은 C4 식물로부터 유래된 당으로 종속 영양적으로 성장한 유지성 유기체로부터 유래된다. 일부 구현예들에서, 이러한 오일의 δ13C(0/00)는 -10 내지 -17 0/00 또는 -13 또는 -16 0/00이다.
일부 사례에서 위의 방법에 따라 생산된 오일들은 미세조류 숙주 세포를 이용하여 만들어진다. 위에 기술된 바와 같이, 미세조류는 제한 없이, 녹조식물 문, 트레보욱시아 강, 클로렐라 목, 클로렐라 과, 또는 녹조 강의 분류에 속한다. 트레보욱시아 강의 미세조류는 그것들의 스테롤 프로파일을 기초로 하여 식물성 오일과 구별될 수 있다. 클로렐라 프로토테코이드에 의해 생산된 오일은 GC-MS로 검출시, 브라시카스테롤, 에르고스테롤, 캄페스테롤, 스티그마스테롤 및 β-시토스테롤인 것으로 나타난 스테롤을 생산하는 것으로 밝혀졌다. 그러나 클로렐라에 의해 생산된 모든 스테롤은 C24β 입체화학을 가지고 있는 것으로 여겨진다. 따라서, 캄페스테롤, 스티그마스테롤 및 β-시토스테롤로 검출된 분자들은 실제로는 각각 22,23-디하이드로브라시카스테롤, 프로페라스테롤 및 클리오나스테롤인 것으로 여겨진다. 따라서, 위에 기술된 미세조류에 의해 생산된 이러한 오일들은 C24β 입체화학을 나타내는 스테롤의 존재 및 존재하는 스테롤에서의 C24α 입체화학의 부재에 의해 식물 오일과 구별될 수 있다. 예를 들어, 생산된 오일들은 22,23-디하이드로브라시카스테롤은 함유하지만 캄페스테롤은 없을 수 있고; 클리오나스테롤은 함유하지만, β-시토스테롤은 없을 수 있고; 및/또는 포리페라스테롤은 함유하지만, 스티그마스테롤은 없을 수 있다. 대안적으로, 또는 추가적으로, 이러한 오일들은 상당한 양의 Δ7-포리페라스테롤을 함유할 수 있다.
일 구현예에서, 본 출원에 제공된 오일들은 식물성 오일이 아니다. 식물성 오일은 식물 및 식물 종자로부터 추출된 오일이다. 식물 오일은 그것들의 오일 함유량을 기초로 하여 본 출원에 제공된 비 식물 오일과 구별될 수 있다. 오일 함유량을 분석하는 다양한 방법들이 오일의 공급원을 결정하기 위하여, 또는 본 출원에 제공된 오일의 상이한(예컨대, 식물) 기원의 오일과의 혼입이 발생했는지를 결정하기 위하여 이용될 수 있다. 이러한 결정은 하나의 분석 방법 또는 분석 방법들의 조합을 기초로 하여 이루어질 수 있다. 이들 시험은 유리 지방산, 지방산 프로파일, 트리아실글리세롤 총 함유량, 디아실글리세롤 함유량, 과산화물값, 분광분석적 성질(예컨대, UV 흡수), 스테롤 프로파일, 스테롤 분해 생성물, 항산화제(예컨대, 토코페롤), 색소(예컨대, 클로로필), d13C 값 및 관능 분석(예컨대, 맛, 냄새 및 구강촉감) 중 하나 이상의 분석을 포함하나, 이에 한정되지 않는다. 많은 이러한 시험들은 식용 유지에 대한 국제식품규격과 같이 상업용 오일에 대해 표준화되었다.
스테롤 프로파일 분석은 특히 유기 물질의 생물학적 공급원을 결정하는 잘 알려진 방법이다. 캄페스테롤, b-시토스테롤 및 스티그마스테롤은 흔한 식물 스테롤이고, b-시토스테롤은 원칙 식물 스테롤이다. 예를 들어, b-시토스테롤은 일부 종자유의 분석에서 최대 존재비로, 대략 옥수수유에서 64%, 유채씨유에서 29%, 해바라기유에서 64%, 면실유에서 74%, 대두유에서 26% 및 올리브유에서 79%로 존재하는 것으로 밝혀졌다(Gul et al. J. Cell and Molecular Biology 5:71-79, 2006).
프로토테카 모리포르미스 균주 UTEX1435로부터 분리된 오일을 별도로 청징화(CL), 정제 및 표백(RB)하거나, 정제, 표백 및 탈취(RBD)하고, JAOCS vol. 60, no.8, August 1983에 기술된 절차에 따라 스테롤 함유량을 시험하였다. 분석 결과를 아래에 나타내었다(단위 mg/100g):
Figure pct00012
이러한 결과들은 세 가지 현저한 특징을 보여준다. 첫째, 에르고스테롤은 모든 스테롤 중에서 가장 풍부한 것으로 밝혀져, 총 스테롤의 약 50% 이상을 차지했다. 에르고스테롤의 양은 캄페스테롤, β-시토스테롤 및 스티그마스테롤을 합한 양보다 많다. 에르고스테롤은 균류에서 흔히 발견되는 스테로이드이며, 식물에서는 흔히 발견되지 않고, 그것의 특히 상당한 양의 존재는 비 식물 오일에 대한 유용한 마커로서 기능한다. 둘째, 이러한 오일은 브라시카스테롤을 함유하는 것으로 밝혀졌다. 유채씨유를 제외하고, 브라시카스테롤은 식물 기반의 오일에서 흔히 발견되지 않는다. 셋째, 2% 미만의 β-시토스테롤이 존재하는 것으로 밝혀졌다. β-시토스테롤은 미세조류에서는 흔히 발견되지 않는 두드러진 식물 스테롤로, 그것의 특히 상당한 양의 존재는 식물 기원의 오일에 대한 유용한 마커로서 기능한다. 요약하자면, 프로토테카 모리포르미스 균주 UTEX1435는 상당한 양의 에르고스테롤과 오로지 미량의 β-시토스테롤을 총 스테롤 함유량의 백분율로서 함유하는 것으로 밝혀졌다. 따라서, 에르고스테롤 : β-시토스테롤 또는 브라시카스테롤의 존재와 조합한 β-시토스테롤의 비율은 이러한 오일을 식물 오일로부터 구별하는 데에 이용될 수 있다.
일부 구현예들에서, 본 출원에 제공된 오일의 오일 함유량은 총 스테롤의 백분율로서, 20%, 15%, 10%, 5%, 4%, 3%, 2%, 또는 1% 미만의 β-시토스테롤을 함유한다. 다른 구현예들에서, 이러한 오일은 β-시토스테롤이 없다.
일부 구현예들에서, 이러한 오일은 β-시토스테롤, 캄페스테롤, 또는 스티그마스테롤 중 하나 이상이 없다. 일부 구현예들에서, 이러한 오일은 β-시토스테롤, 캄페스테롤 및 스티그마스테롤이 없다. 일부 구현예들에서, 이러한 오일은 캄페스테롤이 없다. 일부 구현예들에서, 이러한 오일은 스티그마스테롤이 없다.
일부 구현예들에서, 본 출원에 제공된 오일의 오일 함유량은 총 스테롤의 백분율로서, 20%, 15%, 10%, 5%, 4%, 3%, 2%, 또는 1% 미만의 24-에틸콜레스트-5-엔-3-올을 포함한다. 일부 구현예들에서, 24-에틸콜레스트-5-엔-3-올은 클리오나스테롤이다. 일부 구현예들에서, 본 출원에 제공된 오일의 오일 함유량은 총 스테롤의 백분율로서, 적어도 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 또는 10%의 클리오나스테롤을 포함한다.
일부 구현예들에서, 본 출원에 제공된 오일의 오일 함유량은 총 스테롤의 백분율로서, 20%, 15%, 10%, 5%, 4%, 3%, 2%, 또는 1% 미만의 24-메틸콜레스트-5-엔-3-올을 함유한다. 일부 구현예들에서, 24-메틸콜레스트-5-엔-3-올은 22, 23-디하이드로브라시카스테롤이다. 일부 구현예들에서, 본 출원에 제공된 오일의 오일 함유량은 총 스테롤의 백분율로서, 적어도 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 또는 10%의 22,23-디하이드로브라시카스테롤을 포함한다.
일부 구현예들에서, 본 출원에 제공된 오일의 오일 함유량은 총 스테롤의 백분율로서, 20%, 15%, 10%, 5%, 4%, 3%, 2%, 또는 1% 미만의 5,22-콜레스타디엔-24-에틸-3-올을 함유한다. 일부 구현예들에서, 5, 22-콜레스타디엔-24-에틸-3-올은 포리페라스테롤이다. 일부 구현예들에서, 본 출원에 제공된 오일의 오일 함유량은 총 스테롤의 백분율로서, 적어도 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 또는 10%의 포리페라스테롤을 포함한다.
일부 구현예들에서, 본 출원에 제공된 오일의 오일 함유량은 에르고스테롤 또는 브라시카스테롤 또는 이 둘의 조합을 함유한다. 일부 구현예들에서, 오일 함유량은 총 스테롤의 백분율로서, 적어도 5%, 10%, 20%, 25%, 35%, 40%, 45%, 50%, 55%, 60%, 또는 65%의 에르고스테롤을 함유한다. 일부 구현예들에서, 오일 함유량은 총 스테롤의 백분율로서, 적어도 25%의 에르고스테롤을 함유한다. 일부 구현예들에서, 오일 함유량은 총 스테롤의 백분율로서, 적어도 40%의 에르고스테롤을 함유한다. 일부 구현예들에서, 오일 함유량은 총 스테롤의 백분율로서, 적어도 5%, 10%, 20%, 25%, 35%, 40%, 45%, 50%, 55%, 60%, 또는 65%의 에르고스테롤 및 브라시카스테롤의 조합을 함유한다.
일부 구현예들에서, 오일 함유량은 총 스테롤의 백분율로서, 적어도 1%, 2%, 3%, 4% 또는 5%의 브라시카스테롤을 함유한다. 일부 구현예들에서, 오일 함유량은 총 스테롤의 백분율로서, 10%, 9%, 8%, 7%, 6%, 또는 5% 미만의 브라시카스테롤을 함유한다.
일부 구현예들에서, 에르고스테롤의 브라시카스테롤에 대한 비율은 적어도 5:1, 10:1, 15:1, 또는 20:1이다.
일부 구현예들에서, 오일 함유량은 총 스테롤의 백분율로서, 적어도 5%, 10%, 20%, 25%, 35%, 40%, 45%, 50%, 55%, 60%, 또는 65%의 에르고스테롤 및 20%, 15%, 10%, 5%, 4%, 3%, 2%, 또는 1% 미만의 β-시토스테롤을 함유한다. 일부 구현예들에서, 오일 함유량은 총 스테롤의 백분율로서, 적어도 25%의 에르고스테롤 및 5% 미만의 β-시토스테롤을 함유한다. 일부 구현예들에서, 오일 함유량은 브라시카스테롤을 더 포함한다.
스테롤은 27 내지 29개 탄소 원자들(C27 내지 C29)을 함유하고, 모든 진핵생물에서 발견된다. 동물들은 C27 스테롤을 더 변형하여 C28 및 C29 스테롤을 생산하는 능력이 없기 때문에 오로지 C27 스테롤만 만든다. 그러나 식물들은 C28 및 C29 스테롤을 합성할 수 있고, C28/C29 식물 스테롤은 종종 식물성 스테롤이라 지칭된다. 주어진 식물의 스테롤 프로파일은 C29 스테롤이 높고, 식물에서 주요한 스테롤은 전형적으로 C29 스테롤인 b-시토스테롤과 스티그마스테롤이다. 이와 대조적으로, 비 식물 유기체의 스테롤 프로파일은 더 큰 백분율의 C27 및 C28 스테롤을 함유한다. 예를 들어, 균류 및 많은 미세조류에서의 스테롤은 주로 C28 스테롤이다. 식물에서의 스테롤 프로파일 및 특히 현저한 C28 스테롤에 대한 C29 스테롤의 우세함은 토양 샘플에서 식물 및 해양 물질의 비율을 결정하는 데에 활용되었다(Huang, Wen-Yen, Meinschein W. G., "Sterols as ecological indicators"; Geochimica et Cosmochimia Acta. Vol 43. pp 739-745).
일부 구현예들에서, 본 출원에 제공된 미세조류 오일에서의 주요 스테롤은 b-시토스테롤과 스티그마스테롤 이외의 스테롤이다. 미세조류 오일의 일부 구현예들에서, C29 스테롤은 총 스테롤 함유량의 50%, 40%, 30%, 20%, 10%, 또는 5% 중량 미만을 이룬다.
일부 구현예들에서, 본 출원에 제공된 미세조류 오일은 C29 스테롤보다 더 많은 C28 스테롤을 함유한다. 미세조류 오일의 일부 구현예들에서, C28 스테롤은 총 스테롤 함유량의 50%, 60%, 70%, 80%, 90%, 또는 95% 중량을 초과하여 구성한다. 일부 구현예들에서, C28 스테롤은 에르고스테롤이다. 일부 구현예들에서, C28 스테롤은 브라시카스테롤이다.
본 발명의 구현예들에서, 표 1의 유전자들 중 하나 이상을 발현하는 유지성 세포는 적어도 20, 40, 60 또는 70%의 C8, C10, C12, C14 또는 C16 지방산을 가지고 있는 오일을 생산할 수 있다. 특정 구현예에서, 오일 내의 미리스트산(C14:0)의 수준은 30%를 초과한다.
따라서, 본 발명의 구현예들에는, 본 출원에 논의된 핵산들 중 임의의 핵산으로 세포를 형질전환하는 것을 포함하는, 오일, 트리글리세라이드, 지방산, 또는 이들 중 임의의 것의 유도체를 생산하는 방법이 있다. 또 다른 구현예에서, 형질전환된 세포는 배양되어 오일을 생산하고, 선택적으로 이러한 오일은 추출된다. 이러한 방식으로 추출된 오일은 식품, 함유화학물질 또는 기타 제품을 생산하는 데 이용될 수 있다.
위에 논의된 오일들은, 단독으로 또는 조합시, 식품, 연료 및 (플라스틱, 폼, 필름 등을 포함하는) 화학물질의 생산에 유용하다. 오일, 이러한 오일들로부터의 트리글리세라이드, 지방산은 C-H 활성화, 하이드로아미노메틸화, 메톡시-탄산화, 오존분해, 효소적 전환, 에폭시화, 메틸화, 이합체화, 티올화, 복분해, 하이드로-알킬화, 락톤화, 또는 기타 화학적 공정들을 겪을 수 있다.
오일 추출 후, 잔류 바이오매스가 남을 수 있는데, 이는 연료로서, 동물 사료로서, 종이, 플라스틱, 또는 기타 제품의 성분으로서 용도를 가질 수 있다. 예를 들어, 종속 영양 조류로부터의 잔류 바이오매스는 그러한 제품들에 이용될 수 있다.
실시예 1. 신규한 FATB 서열들의 발견
고등 식물에서 종자 특이적인 중간 사슬(C8-C16) 지방산 생합성과 관련된 신규한 식물 아실-ACP 티오에스테라아제들의 서열들을 분리하였다. 오일 종자에서 축적되는 RNA 풀을 직접적으로 검문하여 종자 특이적인 지질 생산 유전자들을 분리하였다. 계통 발생적 분석을 기초로, 신규한 효소들은 아실-ACP 티오에스테라아제의 FatB 패밀리의 구성원으로 분류될 수 있다.
유지성 식물들의 종자들을 지역의 식료품점으로부터 얻거나, 미국의 북중부 지역 식물 도입국(North Central Regional Plant Introduction Station, NCRIS) 또는 USDA ARS 북중부 토양 보존 연구소(North Central Soil Conservation Research Laboratory, 마이애미 주 모리스)로부터 USDA ARS 국가 식물 생식질 시스템(National Plant Germplasm System, NPGS)를 통해 요청하였다. 건조 종자들을 액체 질소에서 분말까지 균질화하고, 6-8M 요소와 3M LiCl을 함유하는 차가운 추출 완충액에 재현탁시키고, 몇 시간 내지 밤새 얼음 위에서 4℃로 두었다. 종자 균질액을 냉장한 마이크로원심분리기(4℃)에서 20분 동안 20,000 g에서 원심분리하여 뉴클레오스핀(NucleoSpin) 필터(마체레이-나겔(Macherey-Nagel))을 통과시켰다. 그에 따른 RNA 펠릿을 20 mM Tris HCl, pH7.5, 0.5% SDS, 100 mM NaCl, 25 mM EDTA, 2% PVPP를 함유하는 완충액에 재현탁시키고, 이후 RNA를 페놀-클로로포름-이소아밀 알코올(25:24:1, v/v)로 1회 추출하고, 클로로포름으로 1회 추출하였다. RNA를 마지막으로 150 mM의 아세트산염 나트륨 pH5.2의 존재하에 이소프로필 알코올(0.7 부피)로 침전시키고, 원심분리에 의해 80% 에탄올로 세척하고, 건조시켰다. RNA 샘플들을 터보 DNA 분해효소(라이프테크(Lifetech))로 처리하고, 제조사의 프로토콜에 따라 RN이지(RNeasy) 키트(퀴아젠(Qiagen))를 이용하여 더 정제하였다. 그에 따라 정제된 RNA 샘플들을 페어 엔드(pair-end) cDNA 라이브러리로 전환하고, 일루미나(Illumina) Hiseq 2000 플랫폼을 이용하여 차세대 시퀀싱(2x100bp)을 거쳤다. 트리니티(Trinity) 또는 오아시스(Oases) 패키지를 이용하여 RNA 서열 판독물을 상응하는 종자 전사체로 어셈블하였다. 티오에스테라아제를 함유하는 cDNA 콘틱으로 추정되는 것들을 공지된 티오에스테라아제와 상동성이 있는 서열들에 대해 전사체를 마이닝하여 확인하였다. 이러한 인실리코 확인된 추정상의 티오에스테라아제 cDNA들을 종자 RNA 및 전체 길이의 티오에스테라아제 cDNA들을 표적으로 하는 프라이머 쌍들을 이용하여 직접적인 역전사 PCR 분석에 의해 더 검증하였다. 그에 따른 증폭된 생성물들을 클로닝하고, 새롭게(de novo) 시퀀싱하여 확인된 티오에스테라아제 유전자들의 진정성을 확실히 하였다.
신규한 아실-ACP 티오에스테라아제들과 두 개의 기존의 티오에스테라아제 클래스(FatA 및 FatB)의 구성원들 사이의 진화적 및 기능적 관계를 검문하기 위하여, 본 발명자들은 공개된 전체 길이(Mayer and Shanklin, 2007) 및 절단된(THYME 데이터베이스) 아미노산 티오에스테라아제 서열들을 이용하여 계통 발생적 분석을 수행하였다. 신규한 단백질들은 C8-C16 지방산의 생합성과 관련된 공지된 아실-ACP FatB 티오에스테라아제들로 분류되는 것으로 보인다. 또한, 신규한 티오에스테라아제들은 3개의 우세한 외집단으로 무리를 이루는 것으로 보여, 각 클러스터의 구성원들 사이에서 뚜렷한 기능적 유사성 및 진화적 관련성을 시사한다.
다음의 FatB 유전자들의 아미노산 서열들을 표 4에 나타내었다.
[표 4]
FatB 유전자들의 아미노산 서열들
Figure pct00013
Figure pct00014
ChsFATB3j :
MVAAEASSALFSVRTPGTSPKPGKFGNWPTSLSVPFKSKSNHNGGFQVKANASARPKANGSAVSLKSGSLDTQEDTSSSSSPPRTFINQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLMDPFGVDRVVQDGAVFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKMHIEVNRYPTWGDTIEVNTWVSESGKTGMGRDWLISDFHTGDILIRATSVCAMMNQKTRRFSKFPYEVRQELAPHFVDSAPVIEDYQKLHKLDVKTGDSICNGLTPRWNDLDVNQHVNNVKYIGWILESVPTEVFETQELCGLTLEYRQECGRDSVLESVTAMDPSKEGDRSLYQHLLRLEDGTDIAKGRTKWRPKNAGKTSNGNSIS
실시예 2. 신규한 FATB 유전자들로 형질전환된 세포들의 클로닝 및 지방산 분석
아래의 실시예에서, 본 발명자들은 UTEX1435(web.biosci.utexas.edu/utex/) 균주인 균주 A에서 식물 오일 종자 전사체에서 유래된 이종의 티오에스테라아제 발현의 효과를 상세히 열거한다.
실시예 1에서와 같이, RNA를 건조된 식물 종자로부터 추출하여, 일루미나(Illumina) Hiseq 2000 플랫폼을 이용하여 페어드 엔드(paired-end) 시퀀싱을 거쳤다. 트리니티(Trinity) 또는 오아시스(Oases) 패키지를 이용하여 RNA 서열 판독물을 상응하는 종자 전사체로 어셈블하고, 티오에스테라아제를 함유하는 cDNA 콘틱으로 추정되는 것들을 공지된 티오에스테라아제와 상동성이 있는 서열들에 대해 전사체를 마이닝하여 확인하였다. 이러한 인실리코 확인된 추정상의 티오에스테라아제 cDNA들을 종자 RNA 및 전체 길이의 티오에스테라아제 cDNA들을 표적으로 하는 프라이머 쌍들을 이용하여 직접적인 역전사 PCR 분석에 의해 검증하였다. 그에 따른 증폭된 생성물들을 클로닝하고, 새롭게(de novo) 시퀀싱하여 확인된 티오에스테라아제 유전자들의 진정성을 확실히 하고, 상이한 유전자 대립 형질들의 발현으로부터 발생하는 서열 변이형들 또는 종자 집단 내에서의 서열들의 다양성을 확인하였다. 그에 따른 아미노산 서열들을 대상으로 공개된 전체 길이(Mayer and Shanklin, 2007) 및 절단된(THYME 데이터베이스) FatB 서열들을 이용하여 계통 발생적 분석을 하였다. C8-C16 지방산의 생합성에 관련된, 아실-ACP FatB 티오에스테라아제들과 무리를 이룬 티오에스테라아제들을 추적하였다.
아실-ACP FatB 티오에스테라아제를 발현하는 형질전환 벡터의 구축
시나모뭄 캄포라, 쿠페아 히소피폴리아 , 쿠페아 PSR23 , 쿠페아 라이티 , 쿠페아 헤테로필라 및 쿠페아 비스코시씨마 종으로부터의 27개의 추정상의 아실-ACP FatB 티오에스테라아제들을 코돈 최적화된 형태로 합성하여 프로토테카 모리포르미 스(UTEX 1435) 코돈 활용을 반영하였다. 합성된 27개의 유전자들 중에서, 24개가 본 발명자들의 전사체 시퀀싱 결과물에 의해 확인되었고, 쿠페아 비스코시씨마로부터의 3개의 유전자들은 유전자은행(GenBank)의 공개된 서열들로부터 확인되었다.
27개의 FatB 티오에스테라아제들 중 하나를 암호화하는 구성체로 기본 균주인 균주 A(고오일 생산을 위해 전통적인 돌연변이 및 스크리닝에 의해, UTEX 1435로부터 유래된, 프로토테카 모리포르미스)의 형질전환을 통해 형질전환 균주들을 생성하였다. 시나모뭄 캄포라 (Cc) FATB1b을 암호화하는 구성체 pSZ2760을 예로써 나타내었지만, 동일한 방법을 이용하여 상이한 각각의 티오에스테라아제들을 암호화하는 나머지 26개의 구성체들을 생성하였다. 구성체 pSZ2760은 6S::CrTUB2:ScSUC2:CvNR::PmAMT3:CcFATB1b:CvNR::6S로 작성될 수 있다. 형질전환 DNA의 서열은 표 5에 제공하였다(pSZ2760). 5'-3'으로부터 구성체에서 관련 있는 제한 부위들, BspQ1, KpnI, AscI, MfeI, EcoRI, SpeI, XhoI, SacI, BspQ1, 각각을 소문자, 굵은 글자체, 및 밑줄로 표시하였다. BspQ1 부위들은 형질전환 DNA의 5' 및 3' 말단들을 한정한다. 구성체의 5' 및 3' 말단의 굵은 글자체의 소문자 서열들은 상동 재조합을 통해 6S 유전자좌로의 통합을 목표로 하는 UTEX 1435로부터의 게놈 DNA를 나타낸다. 5'에서 3' 방향으로 나아가면서, 선택 카세트는 (수크로오스 상에서 성장하는 능력을 부여하는) S. 세레비시에 유전자 SUC2의 발현을 추진시키는 C. 레인하르드티이(reinhardtii ) β- 튜불린 프로모터 및 클로렐라 불가리스 질산염 환원효소( NR ) 유전자 3' UTR을 가지고 있다. 이러한 프로모터를 소문자의 박스 처리된 텍스트로 나타내었다. ScSUC2에 대한 개시자 ATG와 종결자 TGA는 굵은 글자체, 대문자 이탤릭체로 나타내었고, 부호화 영역은 소문자 이탤릭체로 나타내었다. 3' UTR은 소문자의 밑줄 친 텍스트로 나타내었다. 두 카세트들 사이의 스페이서 영역은 대문자 텍스트로 나타내었다. 시나모뭄 캄포라로부터의 코돈 최적화된 CcFATB1b 유전자(표 5; pSZ2760)를 함유하는 제2의 카세트는 프로토테카 모리포르미스 내생성 AMT3 프로모터에 의해 추진되며, 클로렐라 불가리스 질산염 환원효소(NR) 유전자 3' UTR을 가지고 있다. 이 카세트에서, AMT3 프로모터는 소문자의 박스 처리된 텍스트로 나타내었다. CcFATB1b 유전자에 대한 개시자 ATG와 종결자 TGA는 굵은 글자체, 대문자 이탤릭체로 나타내었고, 부호화 영역은 소문자 이탤릭체로 나타내고, 스페이서 영역은 대문자 텍스트로 나타내었다. 3' UTR은 소문자의 밑줄 친 텍스트로 나타내었다. 최종 구성체를 시퀀싱하여, 정확한 해독틀 및 표적 서열들을 확실히 하였다.
[표 5]
pSZ2760 형질전환 구성체
Figure pct00015
Figure pct00016
표 6의 pSZ2760로부터의 CcFATB1b와 같은, 확인된 이종의 FatB 유전자들을 암호화하는 구성체들을 균주 A 내로 형질전환시키고, 수크로오스 상에서 성장하는 능력에 대해 선택하였다. 형질전환, 세포 배양, 지질 생산 및 지방산 분석은 모두 이전에 기술된 바와 같이 수행하였다. 오일을 축적하기 위하여 낮은 질소 조건 하에서의 수크로오스 상에서의 배양 후, 지방산 프로파일을 FAME-GC로 결정하였다. 최고 수준의 중간 사슬 지방산을 생산하는 능력으로 판단한, 각 형질전환으로부터의 최고 수행자를 표 4에 나타내었다.
[표 6]
이종의 FatB 티오에스테라아제 발현시, S3150에서의 지방산 프로파일의 변화
Figure pct00017
Figure pct00018
Figure pct00019
다수의 아실-ACP FatB 티오에스테라아제들은 프로토테카 모리포르미스에서 발현될 때 중간 사슬 활성을 나타내는 것으로 밝혀졌다. 예를 들어, CcFATB1b의 발현은 모 균주 A에서 총 지방산의 2%로부터 D1670-13 주요 형질전환체에서 약 15%까지 미리스트산 수준의 증가를 초래한다. 다른 예로는 균주 A에서 0%로부터 약 33%까지의 라우르산 수준의 증가를 나타내는 CcFATB4, 약 34%까지 미리스트산 수준의 증가를 나타내는 ChsFATB3를 포함한다. 아실-ACP 티오에스테라아제 중 일부는 현재 구체화한 것에서 중간 사슬 수준에 대해 극적인 효과를 나타내지는 않았지만, 이들 구성체 중 일부를 최적화하고자 활동이 발전될 가능성이 높다.
확인되고 P. 모리포르미스(UTEX 1435)로 형질전환된, 이종의 아실-ACP 티오에스테라아제의 서열들
암호화된 아실-ACP 티오에스테라아제의 추정된 아미노산 서열, 고유의 CDS 부호화 서열, 프로토테카 모리포르미스 코돈 최적화된 부호화 서열 및 조사된 서열 변이형들의 속성과 같은, 형질전환 구성체들에 대한 관련 있는 서열들의 완전한 목록을 서열 번호 1-78로 제공하였다.
실시예 3. 추가적인 FATB 유전자들의 발견 및 클로닝
위에 기술된 종자들로부터 추가적인 FATB 유전자들을 획득하였다. 확인된 FatB 유전자들의 종과 수는 다음과 같다.
Figure pct00020
C8-C16 지방산의 생합성에 관련된, 아실-ACP FatB 티오에스테라아제들과 무리를 이룬 티오에스테라아제들을 추적하였다. 고유한, 추정상의 색소체를 표적으로 하는 전이 펩티드 서열을 밑줄을 그어 나타내었다.
아실-ACP FatB 티오에스테라아제를 발현하는 형질전환 벡터의 구축. 쿠페아 칼카라타, 쿠페아 파인테리, 쿠페아 후케리아나, 쿠페아 아비게라 변이형 풀체리마, 쿠페아 파우시페타라, 쿠페아 프로컴벤스 및 쿠페아 이그네아 종으로부터의 9개의 추정상의 아실-ACP FatB 티오에스테라아제들을 코돈 최적화된 형태로 합성하여 UTEX 1435 코돈 활용을 반영하였다. 이전의 실시예와는 대조적으로, 새로운 아실-ACP FatB 티오에스테라아제들을 고유한 전이 펩티드 대신 클로렐라 프로토테코이드(Cp)로부터의 변형된 전이 펩티드로 합성하였다. CpSAD1 유전자로부터 유래된, 변형된 전이 펩티드 "CpSAD1tp_절단형(trimmed)"을 고유한 전이 펩티드 대신 FatB 아실-ACP 티오에스테라아제에 대한 인프레임(in-frame), N-말단 융합체로 합성하였다. 그에 따른 서열들을 아래에 열거하였다. 신규한 FatB 유전자들을 위에 기술된 바와 같이 프로토테카 모리포르미스 내로 클로닝하였다. 이종의 FatB 유전자들을 암호화하는 구성체들을 균주 S6165(S3150/균주 A의 자손) 내로 형질전환시키고, 수크로오스 상에서 성장하는 능력에 대해 선택하였다. 형질전환, 세포 배양, 지질 생산 및 지방산 분석은 모두 이전에 기술된 바와 같이 수행하였다. 아홉 개의 신규한 FatB 아실-ACP 티오에스테라아제들에 대한 결과를 바로 아래의 표에 표시하였다.
Figure pct00021
Figure pct00022
특히 주목할 것은 17% C10:0 및 8% C8:0 지방산 수준을 나타내는 CpaiFATB1; 9% C10:0 및 1% C12:0 지방산 수준을 나타내는 CpauFATB1; 8% C10:0 및 1% C12:0 지방산 수준을 나타내는 CigneaFATB1; 18% C14:0 및 12% C12:0을 나타내는 CcalcFATB1; 및 22% C8:0 및 9% C10:0 지방산 수준을 나타내는 CaFATB1이다.
높은 C8:0 및 C10:0 수준을 나타내는 CaFATB1은 특히 관심 대상이다. CaFATB1은 쿠페아 아비게라 변이형 풀체리마 전사체로부터 어셈블된 두 개의 별도의 콘틱인 S17_Cavig_trinity_7406 및 S17_Cavig_trinity_7407로부터 발생되었다. 두 개의 부분적인 콘틱들은 중첩되는 겨우 17개 뉴클레오티드들을 나타내지만, 본 발명자들은 두 개의 콘틱들로부터 CaFATB1을 암호화하는 추정상의 전체 길이 전사체를 어셈블한 다음, 이후 종자 RNA 및 전체 길이 CaFATB1 티오에스테라아제 cDNA를 표적으로 하는 프라이머 쌍들을 이용하는 직접적인 역전사 PCR 분석에 의해 전체 길이 전사체의 존재를 확인할 수 있었다. Tjellstrom 등(2013)은 쿠페아 풀체리마로부터 새롭게 확인된 지방 아실-ACP 티오에스테라아제의 발현을 개시하고 있으며, 그들은 이를 "CpuFATB3" (유전자은행 등록번호 KC675178)이라 명명하였다. CpuFATB3의 부호화 서열은 본 발명자들이 확인한 CaFATB1 유전자와 100% 동일하며, 예측된 부호화 영역 외부의 RNA 서열에 하나의 뉴클레오티드 차이를 함유한다. Tjellstrom 등 (2013)은 CpuFATB3이 아라비돕시스에서 발현될 때 평균 4.8% C8:0을 생산하며, 약 12%의 C8.0의 최대 수준과 함께, 평균 9.2%의 C8:0을 생산하기 위해서는 두 개의 아실-ACP 합성효소인 AAE15/16의 결실을 더 필요로 한다는 점을 보여주었다. 본 발명자들이 확인한 CaFATB1 유전자는 UTEX1435에서 발현을 위해 코돈 최적화되었고, S6165로 도입되기 전에 CpSAD1tp이 절단된 전이 펩티드 융합체로서 생성되었다. CpSAD1tp_절단형(trimmed):CaFATB1 유전자는 내생성 아실-ACP 합성효소의 결실을 요구하지 않고도 평균 14%의 C8:0 수준 및 22%의 최대 수준의 C8:0을 생산한다.
[표 7]
추가적인 신규한 FatB 아실-ACP 티오에스테라아제의 아미노산 서열. 첨부된 서열 목록에서, 고유한, 추정상의 색소체를 표적으로 하는 전이 펩티드 서열은 밑줄을 쳤다.
Figure pct00023
실시예 4. FATB 공통 서열: 발견, 클로닝 및 지방산 프로파일
UTEX1435, S3150(위의 균주 A)에서 몇몇 새로운 추정상의 중간 사슬 FatB 티오에스테라아제를 시험하는 과정에서, 본 발명자들은 균주에서 발견된 배경 중간 사슬 수준을 초과하는, 증가된 C10:0 및 C16:0 활성을 나타내는 몇몇 티오에스테라아제들을 확인하였다. 본 발명자들은 가장 우수한 C10:0 및 C16:0 티오에스테라아제들의 정렬로부터 최적화된 C10:0 티오에스테라아제와 C16:0 티오에스테라아제에 대한 공통 서열이 얻어질 수 있다고 추론하였다. 공통의 C10:0 특이적 티오에스테라아제 서열을 C. 파루스트리스 ( palustris ) FatB1(CpFATB1), C. PSR23 FatB3 (CuPSR23FATB3), C. 비스코시씨마 FatB1 (CvisFATB1), C. 글로쏘스토마 (glossostoma) FatB1 (CgFATB1) 및 C. 카르타제네시스 ( carthagenensis ) FatB2 (CcrFATB2) 서열들을 입력물로 이용하여 생성하여, JcFATB1/SzFATB1이라는 C10:0 특이적 공통 서열을 얻었다. 공통의 C16:0 특이적 티오에스테라아제 서열을 C. 헤테로필라 FatB3a(ChtFATB3a), C. 카르타제네시스 FatB1(CcrFATB1), C. 비스코시씨마 FatB2(CvisFATB2), C. 후케리아나 FatB1(ChFATB1; AAC48990), C. 히소피폴리아 FatB2(ChsFATB2), C. 칼로필라 ( calophylla ) FatB2(CcalFATB2; ABB71581), C. 후케리아나 FatB1-1(ChFATB1-1; AAC72882), C. 란세올라타(lanceolata ) FatB1(ClFATB1; CAC19933) 및 C. 라이티 FatB4a(CwFATB4a) 서열들을 입력물로 이용하여 생성하여, JcFATB2/SzFATB2이라는 C16:0 특이적 공통 서열을 얻었다. 그에 따른 공통 서열들을 합성하고, 다른 FatB 티오에스테라아제들을 시험하는 데 사용했던 것과 동일한 벡터 내로 클로닝하고, 위에 기술된 바와 같이 S3150 내로 도입하였다. 공통 아미노산 서열들을 서열 번호 106과 107로 제공하였다. 핵산 서열들은 프로토테카 모리포르미스에 대한 코돈 최적화를 이용하는 이들 아미노산 서열들을 기초로 하였다. 형질전환체들을 선택하고, 배양하고, 오일을 추출하여 FAME-GC-FID로 분석하였다. 얻어진 지방산 프로파일을 아래 표에 제공하였다.
Figure pct00024
실시예 5: 클레드 분석
다양한 신규 FATB 티오에스테라아제들을 이웃 결합 알고리즘에 따라 클러스터링하였다. 이들은 표 1a에 열거된 바와 같이 12개의 클레드를 형성하는 것으로 밝혀졌다. 위에 기술된 바와 같이 프로토테카에서의 발현을 기초로 하여 추정되는 기능을 할당하였다.
본 발명의 기술된 구현예들은 단순히 예시적인 것으로 의도된 것이며, 다양한 변형 및 변경이 당업자에게 명백할 것이다. 모든 이러한 변형 및 변경은 본 발명의 범위 내인 것으로 의도된다.
서열 목록
서열 번호 1:
시나모뭄 캄포라(Cc) FATB1b 변이형 M25L, M322R, ΔT367-D368 아미노산 서열
MATTSLASAFCSMKAVMLARDGRGLKPRSSDLQLRAGNAQTSLKMINGTKFSYTESLKKLPDWSMLFAVITTIFSAAEKQWTNLEWKPKPNPPQLLDDHFGPHGLVFRRTFAIRSYEVGPDRSTSIVAVMNHLQEAALNHAKSVGILGDGFGTTLEMSKRDLIWVVKRTHVAVERYPAWGDTVEVECWVGASGNNGRRHDFLVRDCKTGEILTRCTSLSVMMNTRTRRLSKIPEEVRGEIGPAFIDNVAVKDEEIKKPQKLNDSTADYIQGGLTPRWNDLDINQHVNNIKYVDWILETVPDSIFESHHISSFTIEYRRECTRDSVLQSLTTVSGGSSEAGLVCEHLLQLEGGSEVLRAKTEWRPKLSFRGISVIPAESSV*
서열 번호 2:
시나모뭄 캄포라(Cc) FATB1b 변이형 M25L, M322R, ΔT367-D368 부호화 DNA 서열
CCAGCTTGAAGGTGGGTCTGAGGTATTGAGGGCAAAAACAGAGTGGAGGCCTAAGCTTAGTTTCAGAGGGATTAGTGTGATACCCGCAGAATCGAGTGTCTAA
서열 번호 3:
프로토테카 모리포르미스에 대해 코돈 최적화된 시나모뭄 캄포라(Cc) FATB1b 변이형 M25L, M322R, ΔT367-D368 부호화 DNA 서열
CCAGCTTGAAGGTGGGTCTGAGGTATTGAGGGCAAAAACAGAGTGGAGGCCTAAGCTTAGTTTCAGAGGGATTAGTGTGATACCCGCAGAATCGAGTGTCTAA
서열 번호 4
시나모뭄 캄포라(Cc) FATB4 아미노산 서열
MVTTSLASAYFSMKAVMLAPDGRGIKPRSSGLQVRAGNERNSCKVINGTKVKDTEGLKGCSTLQGQSMLDDHFGLHGLVFRRTFAIRCYEVGPDRSTSIMAVMNHLQEAARNHAESLGLLGDGFGETLEMSKRDLIWVVRRTHVAVERYPAWGDTVEVEAWVGASGNTGMRRDFLVRDCKTGHILTRCTSVSVMMNMRTRRLSKIPQEVRAEIDPLFIEKVAVKEGEIKKLQKLNDSTADYIQGGWTPRWNDLDVNQHVNNIIYVGWIFKSVPDSISENHHLSSITLEYRRECTRGNKLQSLTTVCGGSSEAGIICEHLLQLEDGSEVLRARTEWRPKHTDSFQGISERFPQQEPHK
서열 번호 5
시나모뭄 캄포라(Cc) FATB4 부호화 DNA 서열
TTTCCAAGGCATTAGTGAGAGATTCCCGCAGCAAGAACCGCATAAGTAA
서열 번호 6
프로토테카 모리포르미스에 대해 코돈 최적화된 시나모뭄 캄포라(Cc) FATB4 부호화 DNA 서열
CTTCCAGGGCATCTCCGAGCGCTTCCCCCAGCAGGAGCCCCACAAGTGA
서열 번호 7
시나모뭄 캄포라(Cc) FATB3 아미노산 서열
MVATAAASAFFPVGAPATSSATSAKASMMPDNLDARGIKPKPASSSGLQVKANAHASPKINGSKVSTDTLKGEDTLTSSPAPRTFINQLPDWSMFLAAITTIFLAAEKQWTNLDWKPRRPDMLADPFGIGRFMQDGLIFRQHFAIRSYEIGADRTASIETLMNHLQETALNHVRSAGLLGDGFGATPEMSRRDLIWVVTRMQVLVDRYPAWGDIVEVETWVGASGKNGMRRDWLVRDSQTGEILTRATSVWVMMNKRTRRLSKLPEEVRGEIGPYFIEDVAIIEEDNRKLQKLNENTADNVRRGLTPRWSDLDVNQHVNNVKYIGWILESAPGSILESHELSCMTLEYRRECGKDSVLQSMTAVSGGGSAAGGSPESSVECDHLLQLESGPEVVRGRTEWRPKSANNSRSILEMPAESL
서열 번호 8
시나모뭄 캄포라(Cc) FATB3 부호화 DNA 서열
CTGCATGACCCTTGAATACAGGAGAGAATGTGGGAAGGACAGTGTGCTGCAGTCAATGACTGCTGTCTCTGGTGGAGGCAGTGCAGCAGGTGGCTCACCAGAATCTAGCGTTGAGTGTGACCACTTGCTCCAGCTAGAGAGTGGGCCTGAAGTTGTGAGGGGAAGAACCGAGTGGAGGCCCAAGAGTGCTAATAACTCGAGGAGCATCCTGGAGATGCCGGCCGAGAGC
서열 번호 9
프로토테카 모리포르미스에 대해 코돈 최적화된 시나모뭄 캄포라(Cc) FATB4 부호화 DNA 서열
CTGCATGACCCTGGAGTACCGCCGCGAGTGCGGCAAGGACTCCGTGCTGCAGTCCATGACCGCCGTGTCCGGCGGCGGCTCCGCCGCCGGCGGCTCCCCCGAGTCCTCCGTGGAGTGCGACCACCTGCTGCAGCTGGAGTCCGGCCCCGAGGTGGTGCGCGGCCGCACCGAGTGGCGCCCCAAGTCCGCCAACAACTCCCGCTCCATCCTGGAGATGCCCGCCGAGTCCCTGTGA
서열 번호 10
쿠페아 히소피폴리아(Chs) FATB1 아미노산 서열
MVATNAAAFSAYTFFLTSPTHGYSSKRLADTQNGYPGTSLKSKSTPPPAAAAARNGALPLLASICKCPKKADGSMQLDSSLVFGFQFYIRSYEVGADQTVSIQTVLNYLQEAAINHVQSAGYFGDSFGATPEMTKRNLIWVITKMQVLVDRYPAWGDVVQVDTWTCSSGKNSMQRDWFVRDLKTGDIITRASSVWVLMNRLTRKLSKIPEAVLEEAKLFVMNTAPTVDDNRKLPKLDGSSADYVLSGLTPRWSDLDMNQHVNNVKYIAWILESVPQSIPETHKLSAITVEYRRECGKNSVLQSLTNVSGDGITCGNSIIECHHLLQLETGPEILLARTEWISKEPGFRGAPIQAEKVYNNK*
서열 번호 11
쿠페아 히소피폴리아(Chs) FATB1 부호화 DNA 서열
CAAGGAACCTGGGTTCAGGGGAGCTCCAATCCAGGCAGAGAAAGTCTACAACAACAAATAA
서열 번호 12
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 히소피폴리아(Chs) FATB1 부호화 DNA 서열
CAAGGAGCCCGGCTTCCGCGGCGCCCCCATCCAGGCCGAGAAGGTGTACAACAACAAGTGA
서열 번호 13
쿠페아 히소피폴리아(Chs) FATB2 아미노산 서열
MVATAASSAFFPVPSPDASSRPGKLGNGSSSLSPLKPKLMANGGLQVKANASAPPKINGSSVGLKSGSLKTQEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNDGFGRTLEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRHEIEPHFVDSAPVIEDDDRKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGKGSGSQFQHLLRLEDGGEIVKGRTEWRPKTAGINGPIASGETSPGDSS*
서열 번호 14
쿠페아 히소피폴리아(Chs) FATB2 부호화 DNA 서열
CCTTACCCTGGAATATAGGCGGGAATGCGGAAGGGAGAGCGTGCTGGAGTCCCTCACTGCTGTGGACCCCTCTGGAAAGGGCTCTGGGTCTCAGTTCCAGCACCTTCTGCGGCTTGAGGATGGAGGTGAGATTGTGAAGGGGAGAACTGAGTGGCGACCCAAGACTGCAGGAATCAATGGGCCAATAGCATCCGGGGAGACCTCACCTGGAGACTCTTCTTAG
서열 번호 15
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 히소피폴리아(Chs) FATB2 부호화 DNA 서열
CCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGAGTCCGTGCTGGAGTCCCTGACCGCCGTGGACCCCTCCGGCAAGGGCTCCGGCTCCCAGTTCCAGCACCTGCTGCGCCTGGAGGACGGCGGCGAGATCGTGAAGGGCCGCACCGAGTGGCGCCCCAAGACCGCCGGCATCAACGGCCCCATCGCCTCCGGCGAGACCTCCCCCGGCGACTCCTCCTGA
서열 번호 16
쿠페아 히소피폴리아(Chs) FATB2b +a.a.248-259 변이형 아미노산 서열
MVATAASSAFFPVPSPDASSRPGKLGNGSSSLSPLKPKLMANGGLQVKANASAPPKINGSSVGLKSGSLKTQEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNDGFGRTLEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSKSQIMLPLHYCSVWVMMNQKTRRLSKIPDEVRHEIEPHFVDSAPVIEDDDRKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGKGSGSQFQHLLRLEDGGEIVKGRTEWRPKTAGINGPIASGETSPGDSS*
서열 번호 17
쿠페아 히소피폴리아(Chs) FATB2b+a.a.248-259 변이형 부호화 DNA 서열
TCCACCAGAAGTTCTGGAGACCCAGGAGTTATGTTCCCTTACCCTGGAATATAGGCGGGAATGCGGAAGGGAGAGCGTGCTGGAGTCCCTCACTGCTGTGGACCCCTCTGGAAAGGGCTCTGGGTCTCAGTTCCAGCACCTTCTGCGGCTTGAGGATGGAGGTGAGATTGTGAAGGGGAGAACTGAGTGGCGACCCAAGACTGCAGGAATCAATGGGCCAATAGCATCCGGGGAGACCTCACCTGGAGACTCTTCTTAG
서열 번호 18
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 히소피폴리아(Chs) FATB2b +a.a.248-259 변이형 부호화 DNA 서열
CCCCCCCGAGGTGCTGGAGACCCAGGAGCTGTGCTCCCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGAGTCCGTGCTGGAGTCCCTGACCGCCGTGGACCCCTCCGGCAAGGGCTCCGGCTCCCAGTTCCAGCACCTGCTGCGCCTGGAGGACGGCGGCGAGATCGTGAAGGGCCGCACCGAGTGGCGCCCCAAGACCGCCGGCATCAACGGCCCCATCGCCTCCGGCGAGACCTCCCCCGGCGACTCCTCCTGA
서열 번호 19
쿠페아 히소피폴리아(Chs) FATB3 아미노산 서열
MVAAEASSALFSVRTPGTSPKPGKFGNWPTSLSVPFKSKSNHNGGFQVKANASARPKANGSAVSLKSGSLDTQEDTSSSSSPPRTFINQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLMDPFGVDRVVQDGAVFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKMHVEVNRYPTWGDTIEVNTWVSESGKTGMGRDWLISDCHTGEILIRATSMCAMMNQKTRRFSKFPYEVRQELAPHFVDSAPVIEDYQKLHKLDVKTGDSICNGLTPRWNDLDVNQHVNNVKYIGWILESVPTEVFETQELCGLTLEYRRECGRDSVLESVTAMDPSKEGDRSLYQHLLRLEDGADIAKGRTKWRPKNAGTNGAISTGKTSNGNSIS*
서열 번호 20
쿠페아 히소피폴리아(Chs) FATB3 부호화 DNA 서열
TGGCCTCACCCTTGAGTATAGGCGGGAATGCGGAAGGGACAGTGTGCTGGAGTCCGTGACCGCTATGGATCCATCAAAAGAGGGAGACAGATCTCTGTACCAGCACCTTCTTCGGCTTGAGGATGGGGCTGATATCGCGAAGGGCAGAACCAAGTGGCGGCCGAAGAATGCAGGAACCAATGGGGCAATATCAACAGGAAAGACTTCAAATGGAAACTCGATCTCTTAG
서열 번호 21
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 히소피폴리아(Chs) FATB3 부호화 DNA 서열
CGGCCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGACTCCGTGCTGGAGTCCGTGACCGCCATGGACCCCTCCAAGGAGGGCGACCGCTCCCTGTACCAGCACCTGCTGCGCCTGGAGGACGGCGCCGACATCGCCAAGGGCCGCACCAAGTGGCGCCCCAAGAACGCCGGCACCAACGGCGCCATCTCCACCGGCAAGACCTCCAACGGCAACTCCATCTCCTGA
서열 번호 22
쿠페아 히소피폴리아(Chs) FATB3b (V204I,C239F, E243D, M251V 변이형) 아미노산 서열
MVAAEASSALFSVRTPGTSPKPGKFGNWPTSLSVPFKSKSNHNGGFQVKANASARPKANGSAVSLKSGSLDTQEDTSSSSSPPRTFINQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLMDPFGVDRVVQDGAVFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKMHIEVNRYPTWGDTIEVNTWVSESGKTGMGRDWLISDFHTGDILIRATSVCAMMNQKTRRFSKFPYEVRQELAPHFVDSAPVIEDYQKLHKLDVKTGDSICNGLTPRWNDLDVNQHVNNVKYIGWILESVPTEVFETQELCGLTLEYRRECGRDSVLESVTAMDPSKEGDRSLYQHLLRLEDGADIAKGRTKWRPKNAGTNGAISTGKTSNGNSIS*
서열 번호 23
쿠페아 히소피폴리아(Chs) FATB3b (V204I,C239F, E243D, M251V 변이형) 부호화 DNA 서열
TGGCCTCACCCTTGAGTATAGGCGGGAATGCGGAAGGGACAGTGTGCTGGAGTCCGTGACCGCTATGGATCCCTCAAAAGAGGGAGACAGATCTCTGTACCAGCACCTTCTTCGGCTTGAGGATGGGGCTGATATCGCGAAGGGCAGAACCAAGTGGCGGCCGAAGAATGCAGGAACCAATGGGGCAATATCAACAGGAAAGACTTCAAATGGAAACTCGATCTCTTAG
서열 번호 24
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 히소피폴리아(Chs) FATB3b (V204I,C239F, E243D, M251V 변이형) 부호화 DNA 서열
CGGCCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGACTCCGTGCTGGAGTCCGTGACCGCCATGGACCCCTCCAAGGAGGGCGACCGCTCCCTGTACCAGCACCTGCTGCGCCTGGAGGACGGCGCCGACATCGCCAAGGGCCGCACCAAGTGGCGCCCCAAGAACGCCGGCACCAACGGCGCCATCTCCACCGGCAAGACCTCCAACGGCAACTCCATCTCCTGA
서열 번호 25
쿠페아 PSR23(Cu) FATB3 아미노산 서열
MVVAAATSAFFPVPAPGTSPKPGKSGNWPSSLSPTFKPKSIPNAGFQVKANASAHPKANGSAVNLKSGSLNTQEDTSSSPPPRAFLNQLPDWSMLLTAITTVFVAAEKQWTMLDRKSKRPDMLVDSVGLKCIVRDGLVSRQSFLIRSYEIGADRTASIETLMNHLQETSINHCKSLGLLNDGFGRTPGMCKNDLIWVLTKMQIMVNRYPTWGDTVEINTWFSQSGKIGMASDWLISDCNTGEILIRATSVWAMMNQKTRRFSRLPYEVRQELTPHFVDSPHVIEDNDQKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVSNVKYIGWILESMPIEVLETQELCSLTVEYRRECGMDSVLESVTAVDPSENGGRSQYKHLLRLEDGTDIVKSRTEWRPKNAGTNGAISTSTAKTSNGNSVS*
서열 번호 26
쿠페아 PSR23(Cu) FATB3 부호화 DNA 서열
CTCTCTCACCGTAGAATATAGGCGGGAATGCGGAATGGACAGTGTGCTGGAGTCCGTGACTGCTGTGGATCCCTCAGAAAATGGAGGCCGGTCTCAGTACAAGCACCTTCTGCGGCTTGAGGATGGGACTGATATCGTGAAGAGCAGAACTGAGTGGCGACCGAAGAATGCAGGAACTAACGGGGCGATATCAACATCAACAGCAAAGACTTCAAATGGAAACTCGGTCTCTTAG
서열 번호 27
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 PSR23(Cu) FATB3 부호화 DNA 서열
CTCCCTGACCGTGGAGTACCGCCGCGAGTGCGGCATGGACTCCGTGCTGGAGTCCGTGACCGCCGTGGACCCCTCCGAGAACGGCGGCCGCTCCCAGTACAAGCACCTGCTGCGCCTGGAGGACGGCACCGACATCGTGAAGTCCCGCACCGAGTGGCGCCCCAAGAACGCCGGCACCAACGGCGCCATCTCCACCTCCACCGCCAAGACCTCCAACGGCAACTCCGTGTCCTGA
서열 번호 28
쿠페아 라이티(Cw) FATB3 아미노산 서열
MVVAAAASSAFFPVPAPRTTPKPGKFGNWPSSLSPPFKPKSNPNGRFQVKANVSPHPKANGSAVSLKSGSLNTLEDPPSSPPPRTFLNQLPDWSRLRTAITTVFVAAEKQFTRLDRKSKRPDMLVDWFGSETIVQDGLVFRERFSIRSYEIGADRTASIETLMNHLQDTSLNHCKSVGLLNDGFGRTSEMCTRDLIWVLTKMQIVVNRYPTWGDTVEINSWFSQSGKIGMGRDWLISDCNTGEILVRATSAWAMMNQKTRRFSKLPCEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSICKGLTPGWNDLDVNQHVSNVKYIGWILESMPTEVLETQELCSLTLEYRRECGRESVVESVTSMNPSKVGDRSQYQHLLRLEDGADIMKGRTEWRPKNAGTNRAIST*
서열 번호 29
쿠페아 라이티(Cw) FATB3 부호화 DNA 서열
ATGCTCTCTCACCCTTGAATATAGGCGGGAATGTGGAAGGGAAAGTGTGGTAGAGTCCGTGACCTCTATGAATCCCTCAAAAGTTGGAGACCGGTCTCAGTACCAACACCTTCTGCGGCTTGAGGATGGGGCTGATATCATGAAGGGCAGAACTGAGTGGAGACCAAAGAATGCAGGAACCAACCGGGCGATATCAACATGA
서열 번호 30
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 라이티(Cw) FATB3 부호화 DNA 서열
GTGCTCCCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGAGTCCGTGGTGGAGTCCGTGACCTCCATGAACCCCTCCAAGGTGGGCGACCGCTCCCAGTACCAGCACCTGCTGCGCCTGGAGGACGGCGCCGACATCATGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCACCAACCGCGCCATCTCCACCTGA
서열 번호 31
쿠페아 라이티(Cw) FATB4a 아미노산 서열
MVATAASSAFFPVPSADTSSSRPGKLGSGPSSLSPLKPKSIPNGGLQVKANASAPPKINGSSVGLKSGGFKTQEDSPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGSIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKIAGLSNDGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRNEIEPHFVDSAPVVEDDDRKLPKLDENTADSIRKGLTPRWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSAEGYASRFQHLLRLEDGGEIVKARTEWRPKNAGINGVVPSEESSPGDFF*
서열 번호 32
쿠페아 라이티(Cw) FATB4a 부호화 DNA 서열
CTCCCTGACCCTGGAATACAGGCGGGAATGTGGAAGGGAGAGCGTGCTGGAGTCCCTCACTGCTGTCGACCCGTCTGCAGAGGGCTATGCGTCCCGGTTTCAGCACCTTCTGCGGCTTGAGGATGGAGGTGAGATCGTGAAGGCGAGAACTGAGTGGCGACCCAAGAATGCTGGAATCAATGGGGTGGTACCATCCGAGGAGTCCTCACCTGGAGACTTCTTTTAG
서열 번호 33
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 라이티(Cw) FATB4a 부호화 DNA 서열
CTCCCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGAGTCCGTGCTGGAGTCCCTGACCGCCGTGGACCCCTCCGCCGAGGGCTACGCCTCCCGCTTCCAGCACCTGCTGCGCCTGGAGGACGGCGGCGAGATCGTGAAGGCCCGCACCGAGTGGCGCCCCAAGAACGCCGGCATCAACGGCGTGGTGCCCTCCGAGGAGTCCTCCCCCGGCGACTTCTTCTGA
서열 번호 34
쿠페아 라이티(Cw) FATB4b 아미노산 서열
MVATAASSAFFPVPSADTSSSRPGKLGNGPSSLSPLKPKSIPNGGLQVKANASAPPKINGSSVGLKSGSFKTQEDAPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGSIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKIAGLSSDGFGRTPAMSKRDLIWVVAKMQVMVNRYPAWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRNEIEPHFVDSAPVVEDDDRKLPKLDENTADSIRKGLTPRWNDLDVNQHVNNVKYIGWILESTPAEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGEGDGSKFQHLLRLEDGGEIVKARTEWRPKNAGINGVVPSEESSPGGDFF*
서열 번호 35
쿠페아 라이티(Cw) FATB4b 부호화 DNA 서열
TTCCCTGACCCTGGAATACAGGCGGGAATGTGGAAGGGAGAGCGTGCTGGAGTCCCTCACTGCTGTAGATCCGTCTGGAGAGGGCGATGGGTCCAAGTTCCAGCACCTTCTGCGGCTTGAGGATGGAGGTGAGATCGTGAAGGCGAGAACTGAGTGGCGACCAAAGAATGCTGGAATCAATGGGGTGGTACCATCCGAGGAGTCCTCACCTGGTGGAGACTTCTTTTAA
서열 번호 36
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 라이티(Cw) FATB4b 부호화 DNA 서열
CTCCCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGAGTCCGTGCTGGAGTCCCTGACCGCCGTGGACCCCTCCGGCGAGGGCGACGGCTCCAAGTTCCAGCACCTGCTGCGCCTGGAGGACGGCGGCGAGATCGTGAAGGCCCGCACCGAGTGGCGCCCCAAGAACGCCGGCATCAACGGCGTGGTGCCCTCCGAGGAGTCCTCCCCCGGCGGCGACTTCTTCTGA
서열 번호 37
쿠페아 라이티(Cw) FATB5 아미노산 서열
MVAAAASSAFFSVPTPGTPPKPGKFGNWPSSLSVPFKPDNGGFHVKANASAHPKANGSAVNLKSGSLETPPRSFINQLPDLSVLLSKITTVFGAAEKQWKRPGMLVEPFGVDRIFQDGVFFRQSFSIRSYEIGVDRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKIQVEVNRYPTWGDTIEVNTWVSESGKNGMGRDWLISDCRTGEILIRATSVWAMMNQNTRRLSKFPYEVRQEIAPHFVDSAPVIEDDQKLQKLDVKTGDSIRDGLTPRWNDLDVNQHVNNVKYIGWILKSVPIEVFETQELCGVTLEYRRECGRDSVLESVTAMDPAKEGDRCVYQHLLRLEDGADITIGRTEWRPKNAGANGAMSSGKTSNGNCLIEGRGWQPFRVVRLIF*
서열 번호 38
쿠페아 라이티(Cw) FATB5 부호화 DNA 서열
GACCGCTATGGATCCAGCAAAAGAGGGAGACCGGTGTGTGTACCAGCACCTTCTTCGGCTTGAGGATGGAGCTGATATCACTATAGGCAGAACCGAGTGGCGGCCGAAGAATGCAGGAGCCAATGGTGCAATGTCATCAGGAAAGACTTCAAATGGAAACTGTCTCATAGAAGGAAGGGGTTGGCAACCTTTCCGAGTTGTGCGTTTAATTTTCTGA
서열 번호 39
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 라이티(Cw) FATB5 부호화 DNA 서열
GACCGCCATGGACCCCGCCAAGGAGGGCGACCGCTGCGTGTACCAGCACCTGCTGCGCCTGGAGGACGGCGCCGACATCACCATCGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCGCCAACGGCGCCATGTCCTCCGGCAAGACCTCCAACGGCAACTGCCTGATCGAGGGCCGCGGCTGGCAGCCCTTCCGCGTGGTGCGCCTGATCTTCTGA
서열 번호 40
쿠페아 헤테로필라(Cht) FATB1a 아미노산 서열
MVAAAASSAFFSVPTPGTSTKPGNFGNWPSSLSVPFKPESNHNGGFRVKANASAHPKANGSAVNLKSGSLETQEDTSSSSPPPRTFIKQLPDWGMLLSKITTVFGAAERQWKRPGMLVEPFGVDRIFQDGVFFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKIQVEVNRYPTWGDTIEVNTWVSESGKNGMGRDWLISDCRTGEILIRATSVWAMMNRKTRRLSKFPYEVRQEIAPHFVDSAPVIEDDKKLHKLDVKTGDSIRKGLTPRWNDLDVNQHVNNVKYIGWILKSVPAEVFETQELCGVTLEYRRECGRDSVLESVTAMDTAKEGDRSLYQHLLRLEDGADITIGRTEWRPKNAGANGAISTGKTSNENSVS*
서열 번호 41
쿠페아 헤테로필라(Cht) FATB1a 부호화 DNA 서열
GCGGGAATGTGGAAGGGACAGTGTGCTGGAGTCCGTGACCGCTATGGATACCGCAAAAGAGGGAGACCGGTCTCTGTACCAGCACCTTCTTCGGCTTGAGGATGGGGCTGATATCACCATAGGCAGAACCGAGTGGCGGCCGAAGAATGCAGGAGCCAATGGGGCAATATCAACAGGAAAGACTTCAAATGAAAACTCTGTCTCTTAG
서열 번호 42
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 헤테로필라 (Cht) FATB1a 부호화 DNA 서열
CCGCGAGTGCGGCCGCGACTCCGTGCTGGAGTCCGTGACCGCCATGGACACCGCCAAGGAGGGCGACCGCTCCCTGTACCAGCACCTGCTGCGCCTGGAGGACGGCGCCGACATCACCATCGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCGCCAACGGCGCCATCTCCACCGGCAAGACCTCCAACGAGAACTCCGTGTCCTGA
서열 번호 43
쿠페아 헤테로필라(Cht) FATB1b (P16S, T20P, G94S, G105W, S293F, L305F 변이형) 아미노산 서열
MVAAAASSAFFSVPTSGTSPKPGNFGNWPSSLSVPFKPESSHNGGFQVKANASAHPKANGSAVNLKSGSLETQEDTSSSSPPPRTFIKQLPDWSMLLSKITTVFWAAERQWKRPGMLVEPFGVDRIFQDGVFFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKIQVEVNRYPTWGDTIEVNTWVSESGKNGMGRDWLISDCRTGEILIRATSVWAMMNRKTRRLSKFPYEVRQEIAPHFVDSAPVIEDDKKLHKLDVKTGDFIRKGLTPRWNDFDVNQHVNNVKYIGWILKSVPAEVFETQELCGVTLEYRRECGRDSVLESVTAMDTAKEGDRSLYQHLLRLEDGADITIGRTEWRPKNAGANGAISTGKTSNENSVS*
서열 번호 44
쿠페아 헤테로필라(Cht) FATB1b(P16S, T20P, G94S, G105W, S293F, L305F 변이형) 부호화 DNA 서열
GCGGGAATGTGGAAGGGACAGTGTGCTGGAGTCCGTGACCGCTATGGATACCGCAAAAGAGGGAGACCGGTCTCTGTACCAGCACCTTCTTCGGCTTGAGGATGGGGCTGATATCACCATAGGCAGAACCGAGTGGCGGCCGAAGAATGCAGGAGCCAATGGGGCAATATCAACAGGAAAGACTTCAAATGAAAACTCTGTCTCTTAG
서열 번호 45
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 헤테로필라(Cht) FATB1b (P16S, T20P, G94S, G105W, S293F, L305F 변이형) 부호화 DNA 서열
CCGCGAGTGCGGCCGCGACTCCGTGCTGGAGTCCGTGACCGCCATGGACACCGCCAAGGAGGGCGACCGCTCCCTGTACCAGCACCTGCTGCGCCTGGAGGACGGCGCCGACATCACCATCGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCGCCAACGGCGCCATCTCCACCGGCAAGACCTCCAACGAGAACTCCGTGTCCTGA
서열 번호 46
쿠페아 헤테로필라(Cht) FATB2b 아미노산 서열
MVVAAAASSAFFPVPASGTSPKPGKFGTWLSSSSPSYKPKSNPSGGFQVKANASAHPKANGSAVSLKSGSLNTQEGTSSSPPPRTFLNQLPDWSRLRTAITTVFVAAEKQLTMLDRKSKKPDMHVDWFGLEIIVQDGLVFRESFSIRSYEIGADRTASIETLMNHLQDTSLNHCKSVGLLNDGFGRTPEMCKRDLIWVLTKMQIMVNRYPTWGDTVEINSWFSQSGKIGMGRNWLISDCNTGEILIRATSIWAMMNQKTRRFSKLPNEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSICKGLTPEWNDLDVNQHVSNVKYIGWILESMPKEVLDTQELCSLTLEYRRECGRDSVLESVTAMDPSKVGDRSQYQHLLRLEDGTDIMKGRTEWRPKNAGTNGAISTGKTSNGNSVS*
서열 번호 47
쿠페아 헤테로필라(Cht) FATB2b 부호화 DNA 서열
ATGCTCTCTCACCCTTGAATATAGGCGGGAATGCGGAAGGGATAGTGTGCTGGAGTCTGTGACCGCTATGGATCCCTCAAAAGTTGGAGACCGATCTCAGTACCAGCACCTTCTGCGGCTTGAAGATGGGACTGATATCATGAAGGGCAGAACTGAGTGGCGACCAAAGAATGCAGGAACCAACGGGGCTATATCAACAGGAAAGACTTCAAATGGAAACTCGGTCTCTTAG
서열 번호 48
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 헤테로필라(Cht) FATB2b 부호화 DNA 서열
GTGCTCCCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGACTCCGTGCTGGAGTCCGTGACCGCCATGGACCCCTCCAAGGTGGGCGACCGCTCCCAGTACCAGCACCTGCTGCGCCTGGAGGACGGCACCGACATCATGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCACCAACGGCGCCATCTCCACCGGCAAGACCTCCAACGGCAACTCCGTGTCCTGA
서열 번호 49
쿠페아 헤테로필라(Cht) FATB2a (S17P, P21S, T28N, L30P, S33L, G76D, S78P, G137W 변이형) 아미노산 서열
MVVAAAASSAFFPVPAPGTTSKPGKFGNWPSSLSPSFKPKSNPNGGFQVKANASAHPKANGSAVSLKSGSLNTKEDTPSSPPPRTFLNQLPDWSRLRTAITTVFVAAEKQLTMLDRKSKKPDMHVDWFGLEIIVQDWLVFRESFSIRSYEIGADRTASIETLMNHLQDTSLNHCKSVGLLNDGFGRTPEMCKRDLIWVLTKMQIMVNRYPTWGDTVEINSWFSQSGKIGMGRNWLISDCNTGEILIRATSIWAMMNQKTRRFSKLPNEVRQEIAPHFVDAPPLIEDNDRKLHKFDVKTGDSICKGLTPEWNDLDVNQHVSNVKYIGWILESMPKEVLDTQELCSLTLEYRRECGRDSVLESVTAMDPSKVGDRSQYQHLLRLEDGTDIMKGRTEWRPKNAGTNGAISTGKTSNGNSVS*
서열 번호 50
쿠페아 헤테로필라(Cht) FATB2a (S17P, P21S, T28N, L30P, S33L, G76D, S78P, G137W 변이형) 부호화 DNA 서열
ATGCTCTCTCACCCTTGAATATAGGCGGGAATGCGGAAGGGACAGTGTGCTGGAGTCTGTGACCGCTATGGATCCCTCAAAAGTTGGAGACCGATCTCAGTACCAGCACCTTCTGCGGCTTGAAGATGGGACTGATATCATGAAGGGCAGAACTGAGTGGCGACCAAAGAATGCAGGAACCAACGGGGCGATATCAACAGGAAAGACTTCAAATGGAAACTCGGTCTCTTAG
서열 번호 51
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 헤테로필라(Cht) FATB2a (S17P, P21S, T28N, L30P, S33L, G76D, S78P, G137W 변이형) 부호화 DNA 서열
GTGCTCCCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGACTCCGTGCTGGAGTCCGTGACCGCCATGGACCCCTCCAAGGTGGGCGACCGCTCCCAGTACCAGCACCTGCTGCGCCTGGAGGACGGCACCGACATCATGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCACCAACGGCGCCATCTCCACCGGCAAGACCTCCAACGGCAACTCCGTGTCCTGA
서열 번호 52
쿠페아 헤테로필라(Cht) FATB2c (G76D, S78P 변이형) 아미노산 서열
MVVAAAASSAFFPVPASGTSPKPGKFGTWLSSSSPSYKPKSNPSGGFQVKANASAHPKANGSAVSLKSGSLNTKEDTPSSPPPRTFLNQLPDWNRLRTAITTVFVAAEKQLTMLDRKSKKPDMHVDWFGLEIIVQDGLVFRESFSIRSYEIGADRTASIETLMNHLQDTSLNHCKSVGLLNDGFGRTPEMCKRDLIWVLTKMQIMVNRYPTWGDTVEINSWFSQSGKIGMGRNWLISDCNTGEILIRATSIWAMMNQKTRRFSKLPNEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSICKGLTPEWNDLDVNQHVSNVKYIGWILESMPKEVLDTQELCSLTLEYRRECGRDSVLESVTAMDPSKVGDRSQYQHLLRLEDGTDIMKGRTEWRPKNAGTNGAISTGKTSNGNSVS*
서열 번호 53
쿠페아 헤테로필라(Cht) FATB2c (G76D, S78P 변이형) 부호화 DNA 서열
ATGCTCTCTCACCCTTGAATATAGGCGGGAATGCGGAAGGGACAGTGTGCTGGAGTCTGTGACCGCTATGGATCCCTCAAAAGTTGGGGACCGATCTCAGTACCAGCACCTTCTGCGGCTTGAAGATGGGACTGATATCATGAAGGGCAGAACTGAGTGGCGACCAAAGAATGCAGGAACCAACGGGGCTATATCAACAGGAAAGACTTCAAATGGAAACTCGGTCTCTTAG
서열 번호 54
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 헤테로필라(Cht) FATB2c (G76D, S78P 변이형) 부호화 DNA 서열
GTGCTCCCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGACTCCGTGCTGGAGTCCGTGACCGCCATGGACCCCTCCAAGGTGGGCGACCGCTCCCAGTACCAGCACCTGCTGCGCCTGGAGGACGGCACCGACATCATGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCACCAACGGCGCCATCTCCACCGGCAAGACCTCCAACGGCAACTCCGTGTCCTGA
서열 번호 55
쿠페아 헤테로필라(Cht) FATB2d (S21P, T28N, L30P, S33L, G76D, R97L, H124L, W127L, I132S, K258N, C303R, E309G, K334T, T386A 변이형) 아미노산 서열
MVVAAAASSAFFPVPAPGTTSKPGKFGNWPSSLSPSFKPKSNPNGGFQVKANASAHPKANGSAVSLKSGSLNTQEDTSSSPPPRTFLNQLPDWSRLLTAISTVFVAAEKQLTMLDRKSKRPDMLVDLFGLESIVQDGLVFRESYSIRSYEIGADRTASIETLMNHLQDTSLNHCKSVGLLNDGFGRTPEMCKRDLIWVLTKMQIMVNRYPTWGDTVEINSWFSQSGKIGMGRNWLISDCNTGEILIRATSIWAMMNQNTRRFSKLPNEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSIRKGLTPGWNDLDVNQHVSNVKYIGWILESMPTEVLETQELCSLTLEYRRECGRESVLESVTAMNPSKVGDRSQYQHLLRLEDGADIMKGRTEWRPKNAGTNGAISTGKTSNGNSVS*
서열 번호 56
쿠페아 헤테로필라(Cht) FATB2d (S21P, T28N, L30P, S33L, G76D, R97L, H124L, W127L, I132S, K258N, C303R, E309G, K334T, T386A 변이형) 부호화 DNA 서열
ATGCTCTCTCACCCTTGAATATAGGCGGGAATGCGGAAGGGAAAGTGTGCTGGAGTCCGTGACCGCTATGAATCCCTCAAAAGTTGGAGACCGGTCTCAGTACCAGCACCTTCTACGGCTTGAGGATGGGGCTGATATCATGAAGGGCAGAACTGAGTGGCGACCAAAGAATGCAGGAACCAACGGGGCGATATCAACAGGAAAGACTTCAAATGGAAACTCGGTCTCTTAG
서열 번호 57
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 헤테로필라 (Cht) FATB2d (S21P, T28N, L30P, S33L, G76D, R97L, H124L, W127L, I132S, K258N, C303R, E309G, K334T, T386A 변이형) 부호화 DNA 서열
GTGCTCCCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGAGTCCGTGCTGGAGTCCGTGACCGCCATGAACCCCTCCAAGGTGGGCGACCGCTCCCAGTACCAGCACCTGCTGCGCCTGGAGGACGGCGCCGACATCATGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCACCAACGGCGCCATCTCCACCGGCAAGACCTCCAACGGCAACTCCGTGTCCTGA
서열 번호 58
쿠페아 헤테로필라(Cht) FATB2e (G76D, R97L, H124L, I132S, G152S, H165L, T211N, K258N, C303R, E309G, K334T, T386A 변이형) 아미노산 서열
MVVAAAASSAFFPVPASGTSPKPGKFGTWLSSSSPSYKPKSNPSGGFQVKANASAHPKANGSAVSLKSGSLNTQEDTSSSPPPQTFLNQLPDWSRLLTAISTVFVAAEKQLTMLDRKSKRPDMLVDWFGLESIVQDGLVFRESYSIRSYEISADRTASIETVMNLLQETSLNHCKSMGILNDGFGRTPEMCKRDLIWVLTKMQILVNRYPNWGDTVEINSWFSQSGKIGMGRNWLISDCNTGEILIRATSIWAMMNQNTRRFSKLPNEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSIRKGLTPGWNDLDVNQHVSNVKYIGWILESMPTEVLETQELCSLTLEYRRECGRDSVLESVTAMNPSKVGDRSQYQHLLRLEDGADIMKGRTEWRPKNAGTNGAISTGKTSNGNSVS*
서열 번호 59
쿠페아 헤테로필라(Cht) FATB2e (G76D, R97L, H124L, I132S, G152S, H165L, T211N, K258N, C303R, E309G, K334T, T386A 변이형) 부호화 DNA 서열
ATGCTCTCTCACCCTTGAATATAGGCGGGAATGCGGAAGGGACAGTGTGCTGGAGTCCGTGACCGCTATGAATCCCTCAAAAGTTGGAGACCGGTCTCAGTACCAGCACCTTCTACGGCTTGAGGATGGGGCTGATATCATGAAGGGCAGAACTGAGTGGCGACCAAAGAATGCAGGAACCAACGGGGCGATATCAACAGGAAAGACTTCAAATGGAAACTCGGTCTCTTAG
서열 번호 60
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 헤테로필라(Cht) FATB2e (G76D, R97L, H124L, I132S, G152S, H165L, T211N, K258N, C303R, E309G, K334T, T386A 변이형) 부호화 DNA 서열
GTGCTCCCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGACTCCGTGCTGGAGTCCGTGACCGCCATGAACCCCTCCAAGGTGGGCGACCGCTCCCAGTACCAGCACCTGCTGCGCCTGGAGGACGGCGCCGACATCATGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCACCAACGGCGCCATCTCCACCGGCAAGACCTCCAACGGCAACTCCGTGTCCTGA
서열 번호 61
쿠페아 헤테로필라(Cht) FATB2f (R97L, H124L, I132S, G152S, H165L, T211N 변이형) 아미노산 서열
MVVAAAASSAFFPVPASGTSPKPGKFGTWLSSSSPSYKPKSNPSGGFQVKANASAHPKANGSAVSLKSGSLNTQEGTSSSPPPRTFLNQLPDWSRLLTAISTVFVAAEKQLTMLDRKSKRPDMLVDWFGLESIVQDGLVFRESYSIRSYEISADRTASIETVMNLLQETSLNHCKSMGILNDGFGRTPEMCKRDLIWVLTKMQILVNRYPNWGDTVEINSWFSQSGKIGMGRNWLISDCNTGEILIRATSIWAMMNQKTRRFSKLPNEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSICKGLTPEWNDLDVNQHVSNVKYIGWILESMPKEVLDTQELCSLTLEYRRECGRDSVLESVTAMDPSKVGDRSQYQHLLRLEDGTDIMKGRTEWRPKNAGTNGAISTGKTSNGNSVS*
서열 번호 62
쿠페아 헤테로필라(Cht) FATB2f (R97L, H124L, I132S, G152S, H165L, T211N 변이형) 부호화 DNA 서열
ATGCTCTCTCACCCTTGAATATAGGCGGGAATGCGGAAGGGACAGTGTGCTGGAGTCTGTGACCGCTATGGATCCCTCAAAAGTTGGAGACCGATCTCAGTACCAGCACCTTCTGCGGCTTGAAGATGGGACTGATATCATGAAGGGCAGAACTGAGTGGCGACCAAAGAATGCAGGAACCAACGGGGCGATATCAACAGGAAAGACTTCAAATGGAAACTCGGTCTCTTAG
서열 번호 63
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 헤테로필라(Cht) FATB2f (R97L, H124L, I132S, G152S, H165L, T211N 변이형) 부호화 DNA 서열
GTGCTCCCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGACTCCGTGCTGGAGTCCGTGACCGCCATGGACCCCTCCAAGGTGGGCGACCGCTCCCAGTACCAGCACCTGCTGCGCCTGGAGGACGGCACCGACATCATGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCACCAACGGCGCCATCTCCACCGGCAAGACCTCCAACGGCAACTCCGTGTCCTGA
서열 번호 64
쿠페아 헤테로필라(Cht) FATB2g (A6T, A16V, S17P, G76D, R97L, H124L, I132S, S143I, G152S, A157T, H165L, T211N, G414A 변이형) 아미노산 서열
MVVAATASSAFFPVPVPGTSPKPGKFGTWLSSSSPSYKPKSNPSGGFQVKANASAHPKANGSAVSLKSGSLNTQEDTSSSPPPRTFLNQLPDWSRLLTAISTVFVAAEKQLTMLDRKSKRPDMLVDWFGLESIVQDGLVFREIYSIRSYEISADRTTSIETVMNLLQETSLNHCKSMGILNDGFGRTPEMCKRDLIWVLTKMQILVNRYPNWGDTVEINSWFSQSGKIGMGRNWLISDCNTGEILIRATSIWAMMNQKTRRFSKLPNEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSICKGLTPEWNDLDVNQHVSNVKYIGWILESMPKEVLDTQELCSLTLEYRRECGRDSVLESVTAMDPSKVGDRSQYQHLLRLEDGTDIMKGRTEWRPKNAGTNGAISTGKTSNANSVS*
서열 번호 65
쿠페아 헤테로필라(Cht) FATB2g (A6T, A16V, S17P, G76D, R97L, H124L, I132S, S143I, G152S, A157T, H165L, T211N, G414A 변이형) 부호화 DNA 서열
ATGCTCTCTCACCCTTGAATATAGGCGGGAATGCGGAAGGGACAGTGTGCTGGAGTCTGTGACCGCTATGGATCCCTCAAAAGTTGGAGACCGATCTCAGTACCAGCACCTTCTGCGGCTTGAAGATGGGACTGATATCATGAAGGGCAGAACTGAGTGGCGACCAAAGAATGCAGGAACCAACGGGGCGATATCAACAGGAAAGACTTCAAATGCAAACTCGGTCTCTTAG
서열 번호 66
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 헤테로필라(Cht) FATB2g (A6T, A16V, S17P, G76D, R97L, H124L, I132S, S143I, G152S, A157T, H165L, T211N, G414A 변이형) 부호화 DNA 서열
GTGCTCCCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGACTCCGTGCTGGAGTCCGTGACCGCCATGGACCCCTCCAAGGTGGGCGACCGCTCCCAGTACCAGCACCTGCTGCGCCTGGAGGACGGCACCGACATCATGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCACCAACGGCGCCATCTCCACCGGCAAGACCTCCAACGCCAACTCCGTGTCCTGA
서열 번호 67
쿠페아 헤테로필라(Cht) FATB3a아미노산 서열
MVATAASSAFFPVPSPDTSSRPGKLGNGSSSLRPLKPKFVANAGLQVKANASAPPKINGSSVSLKSCSLKTHEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNEGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRKLSKIPDEVRHEIEPHFVDSAPVIEDDDWKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGKGFGPQFQHLLRLEDGGEIVKGRTEWRPKTAGINGTIASGETSPGNS*
서열 번호 68
쿠페아 헤테로필라(Cht) FATB3a 부호화 DNA 서열
CCTTACCCTGGAATACAGGCGGGAATGCGGAAGGGAGAGTGTGCTGGAGTCCCTCACTGCTGTGGACCCCTCTGGAAAGGGCTTTGGGCCCCAGTTTCAGCACCTTCTGAGGCTTGAGGATGGAGGTGAGATCGTAAAGGGGAGAACTGAGTGGCGACCCAAGACTGCAGGTATCAATGGGACGATTGCATCTGGGGAGACCTCACCTGGAAACTCTTAG
서열 번호 69
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 헤테로필라(Cht) FATB3a 부호화 DNA 서열
CCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGAGTCCGTGCTGGAGTCCCTGACCGCCGTGGACCCCTCCGGCAAGGGCTTCGGCCCCCAGTTCCAGCACCTGCTGCGCCTGGAGGACGGCGGCGAGATCGTGAAGGGCCGCACCGAGTGGCGCCCCAAGACCGCCGGCATCAACGGCACCATCGCCTCCGGCGAGACCTCCCCCGGCAACTCCTGA
서열 번호 70
쿠페아 헤테로필라(Cht) FATB3b (C67G, H72Q, L128F, N179I 변이형) 아미노산 서열
MVATAASSAFFPVPSPDTSSRPGKLGNGSSSLRPLKPKFVANAGLQVKANASAPPKINGSSVSLKSGSLKTQEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGFGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLIEGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRKLSKIPDEVRHEIEPHFVDSAPVIEDDDWKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGKGFGPQFQHLLRLEDGGEIVKGRTEWRPKTAGINGTIASGETSPGNS*
서열 번호 71
쿠페아 헤테로필라(Cht) FATB3b (C67G, H72Q, L128F, N179I 변이형) 부호화 DNA 서열
CCTTACCCTGGAATACAGGCGGGAATGCGGAAGGGAGAGTGTGCTGGAGTCCCTCACTGCTGTGGACCCCTCTGGAAAGGGCTTTGGGCCCCAGTTTCAGCACCTTCTGAGGCTTGAGGATGGAGGTGAGATCGTAAAGGGGAGAACTGAGTGGCGACCCAAGACTGCAGGTATCAATGGGACGATTGCATCTGGGGAGACCTCACCTGGAAACTCTTAG
서열 번호 72
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 헤테로필라(Cht) FATB3b (C67G, H72Q, L128F, N179I 변이형) 부호화 DNA 서열
CCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGAGTCCGTGCTGGAGTCCCTGACCGCCGTGGACCCCTCCGGCAAGGGCTTCGGCCCCCAGTTCCAGCACCTGCTGCGCCTGGAGGACGGCGGCGAGATCGTGAAGGGCCGCACCGAGTGGCGCCCCAAGACCGCCGGCATCAACGGCACCATCGCCTCCGGCGAGACCTCCCCCGGCAACTCCTGA
서열 번호 73
쿠페아 비스코시씨마(Cvis) FATB1 아미노산 서열
MVAAAATSAFFPVPAPGTSPKPGKSGNWPSSLSPTFKPKSIPNGGFQVKANASAHPKANGSAVNLKSGSLNTQEDTSSSPPPRAFLNQLPDWSMLLTAITTVFVAAEKQWTMLDRKSKRPDMLVDSVGLKSIVRDGLVSRHSFSIRSYEIGADRTASIETLMNHLQETTINHCKSLGLHNDGFGRTPGMCKNDLIWVLTKMQIMVNRYPTWGDTVEINTWFSQSGKIGMASDWLISDCNTGEILIRATSVWAMMNQKTRRFSRLPYEVRQELTPHFVDSPHVIEDNDQKLRKFDVKTGDSIRKGLTPRWNDLDVNQHVSNVKYIGWILESMPIEVLETQELCSLTVEYRRECGMDSVLESVTAVDPSENGGRSQYKHLLRLEDGTDIVKSRTEWRPKNAGTNGAISTSTAKTSNGNSVS
서열 번호 74
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 비스코시씨마(Cvis) FATB1 부호화 DNA 서열
CTCCCTGACCGTGGAGTACCGCCGCGAGTGCGGCATGGACTCCGTGCTGGAGTCCGTGACCGCCGTGGACCCCTCCGAGAACGGCGGCCGCTCCCAGTACAAGCACCTGCTGCGCCTGGAGGACGGCACCGACATCGTGAAGTCCCGCACCGAGTGGCGCCCCAAGAACGCCGGCACCAACGGCGCCATCTCCACCTCCACCGCCAAGACCTCCAACGGCAACTCCGTGTCCTGA
서열 번호 75
쿠페아 비스코시씨마(Cvis) FATB2 아미노산 서열
MVATAASSAFFPVPSADTSSRPGKLGNGPSSFSPLKPKSIPNGGLQVKASASAPPKINGSSVGLKSGGLKTHDDAPSAPPPRTFINQLPDWSMLLAAITTAFLAAEKQWMMLDRKPKRLDMLEDPFGLGRVVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKTAGLSNDGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRKLSKIPDEVRREIEPHFVDSAPVIEDDDRKLPKLDEKSADSIRKGLTPRWNDLDVNQHVNNAKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGEGYGSQFQHLLRLEDGGEIVKGRTEWRPKNAGINGVVPSEESSPGDYS
서열 번호 76
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 비스코시씨마(Cvis) FATB2 부호화 DNA 서열
CCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGAGTCCGTGCTGGAGTCCCTGACCGCCGTGGACCCCTCCGGCGAGGGCTACGGCTCCCAGTTCCAGCACCTGCTGCGCCTGGAGGACGGCGGCGAGATCGTGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCATCAACGGCGTGGTGCCCTCCGAGGAGTCCTCCCCCGGCGACTACTCCTGA
서열 번호 77
쿠페아 비스코시씨마(Cvis) FATB3 아미노산 서열
MVAAAASSAFFSFPTPGTSPKPGKFGNWPSSLSIPFNPKSNHNGGIQVKANASAHPKANGSAVSLKAGSLETQEDTSSPSPPPRTFISQLPDWSMLVSAITTVFVAAEKQWTMLDRKSKRPDVLVEPFVQDGVSFRQSFSIRSYEIGVDRTASIETLMNIFQETSLNHCKSLGLLNDGFGRTPEMCKRDLIWVVTKMQIEVNRYPTWGDTIEVTTWVSESGKNGMSRDWLISDCHSGEILIRATSVWAMMNQKTRRLSKIPDEVRQEIVPYFVDSAPVIEDDRKLHKLDVKTGDSIRNGLTPRWNDFDVNQHVNNVKYIAWLLKSVPTEVFETQELCGLTLEYRRECRRDSVLESVTAMDPSKEGDRSLYQHLLRLENGADIALGRTEWRPKNAGATGAVSTGKTSNGNSVS
서열 번호 78
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 비스코시씨마(Cvis) FATB3 부호화 DNA 서열
GTACCGCCGCGAGTGCCGCCGCGACTCCGTGCTGGAGTCCGTGACCGCCATGGACCCCTCCAAGGAGGGCGACCGCTCCCTGTACCAGCACCTGCTGCGCCTGGAGAACGGCGCCGACATCGCCCTGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCGCCACCGGCGCCGTGTCCACCGGCAAGACCTCCAACGGCAACTCCGTGTCCTGA
서열 번호 79
쿠페아 칼카라타(Ccalc) FATB1 아미노산 서열
MVAASASSAFFSVPTPGTSPKPGKFGNWPSSLSVPFKPRSNNSGGFQVKANASAHPKANGSAVSLKSGSLETQEDNSSSSRPPRTFIKQLPDWSMLLSAITTVFVAAEKQWTMFDRKSKRSDMLVDPFVVDRIVQDGVLFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSMGLLYEGFGRTPEMCKRDLIWVVTKIHIKVNRYPTWGDTIEVTTWVSESGKNGMGRDWLISDCHTGEILIRATSVWAMMNQTTRRLSKFPYELRQEIAPHFVDSDPVIEDNRRLLNFDVKTGDSIRKGLTPRWNDLDVNQHVNNVKYIGWILESVPTEVFDTRELCGLTLEYRQECGRGSVLESVTAMDPSKEGDRSLYQHLLRLEDGTDIVKGRTEWRPKNAGTNGPVSTRKTTNGSSVS
서열 번호 80
쿠페아 칼카라타(Ccalc) FATB1 부호화 DNA 서열
CGGCCTCACCCTTGAGTATAGGCAGGAATGCGGAAGAGGAAGTGTGCTGGAGTCCGTGACCGCTATGGATCCCTCAAAAGAGGGAGACCGGTCTCTGTACCAGCACCTTCTTCGGCTTGAGGATGGGACTGATATCGTGAAGGGCAGAACCGAGTGGCGGCCAAAGAATGCAGGAACCAATGGGCCAGTATCAACAAGAAAGACTACAAATGGAAGCTCAGTCTCTTAG
서열 번호 81
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 칼카라타(Ccalc) FATB1 부호화 DNA 서열
CGGCCTGACCCTGGAGTACCGCCAGGAGTGCGGCCGCGGCTCCGTGCTGGAGTCCGTGACCGCCATGGACCCCTCCAAGGAGGGCGACCGCTCCCTGTACCAGCACCTGCTGCGCCTGGAGGACGGCACCGACATCGTGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCACCAACGGCCCCGTGTCCACCCGCAAGACCACCAACGGCTCCTCCGTGTCCTGA
서열 번호 82
쿠페아 파인테리(Cpai) FATB1 아미노산 서열
MVAAAATSAFFPVPAPGTSPNPRKFGSWPSSLSPSLPKSIPNGGFQVKANASAHPKANGSAVSLKSGSLNTQENTSSSPPPRTFLHQLPDWSRLLTAITTVFVKSKRPDMHDRKSKRPDMLVDLFGLESSVQDALVFRQSFSIRSYEIGTDRTASIETLMNHLQETSLNHCKSTGILLDGFGRTLEMCKRELIWVVIKMQIQVNRYPAWGDTVEINTRFSRLGKIGMGRDWLISDCNTGEILIRATSEYAMMNQKTRRLSKLPYEVHQEIAPLFVDSPPVIEDNDLKVHKFEVKTGDSIQKGLSPGWNDLDVNQHVSNVKYIGWILESMPTEVLETQELCSLALEYRRECGRDSVLESVTAMDPSKVGGRSQYQHLLRLEDGTAIVNGITEWRPKNAGANGAISTGKTSNGNSVS
서열 번호 83
쿠페아 파인테리(Cpai) FATB1 부호화 DNA 서열
CGCCCTTGAATATAGGCGGGAATGCGGAAGGGACAGTGTGCTGGAGTCCGTGACCGCAATGGATCCCTCAAAAGTTGGAGGCCGTTCTCAGTACCAGCACCTTCTGCGGCTTGAGGATGGGACTGCTATCGTGAACGGCATAACTGAGTGGCGGCCGAAGAATGCAGGAGCTAATGGGGCGATATCAACGGGAAAGACTTCAAATGGAAACTCGGTCTCTTAG
서열 번호 84
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 파인테리(Cpai) FATB1 부호화 DNA 서열
GGCCCTGGAGTACCGCCGCGAGTGCGGCCGCGACTCCGTGCTGGAGTCCGTGACCGCCATGGACCCCTCCAAGGTGGGCGGCCGCTCCCAGTACCAGCACCTGCTGCGCCTGGAGGACGGCACCGCCATCGTGAACGGCATCACCGAGTGGCGCCCCAAGAACGCCGGCGCCAACGGCGCCATCTCCACCGGCAAGACCTCCAACGGCAACTCCGTGTCCTGA
서열 번호 85
쿠페아 후케리아나(Chook) FATB4 아미노산 서열
MVAAAATSAFFPVPAPGTSPNPRKFGSWPSSLSPSLPNSIPNGGFQVKANASAHPKANGSAVSLKSGSLNTQENTSSSPPPRTFLHQLPDWSRLLTAITTVFVKSKRPDMHDRKSKRPDMLVDLFGLESSVQDALVFRQRFSIRSYEIGTDRTASMETLMNHLQETSLNHCKSTGILLDGFGRTLEMCKRELIWVVIKMQIQVNRYPAWGDTVEINTRFSRLGKIGMGRDWLISDCNTGEILIRATSEYAMMNQKTRRLSKLPYEVRQEIAPLFVDSPPVIEDNDLKVHKFEVKTGDSIHKGLTPGWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAMDPSGGGYGSQFQHLLRLEDGGEIVKGRTEWRPKNGVINGVVPTGESSPGDYS
서열 번호 86
쿠페아 후케리아나(Chook) FATB4 부호화 DNA 서열
TACTCTGGAATACAGGCGGGAATGTGGAAGGGAGAGCGTGCTGGAGTCCCTCACTGCTATGGATCCCTCTGGAGGGGGTTATGGGTCCCAGTTTCAGCACCTTCTGCGGCTTGAGGATGGAGGTGAGATCGTGAAGGGGAGAACCGAGTGGCGACCCAAGAATGGTGTAATCAATGGGGTGGTACCAACCGGGGAGTCCTCACCTGGAGACTACTCTTAG
서열 번호 87
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 후케리아나(Chook) FATB4 부호화 DNA 서열
GACCCTGGAGTACCGCCGCGAGTGCGGCCGCGAGTCCGTGCTGGAGTCCCTGACCGCCATGGACCCCTCCGGCGGCGGCTACGGCTCCCAGTTCCAGCACCTGCTGCGCCTGGAGGACGGCGGCGAGATCGTGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGGCGTGATCAACGGCGTGGTGCCCACCGGCGAGTCCTCCCCCGGCGACTACTCCTGA
서열 번호 88
쿠페아 아비게라 변이형 풀체리마(Ca) FATB1 아미노산 서열
MVAAAASSAFFSVPVPGTSPKPGKFRIWPSSLSPSFKPKPIPNGGLQVKANSRAHPKANGSAVSLKSGSLNTQEDTSSSPPPRTFLHQLPDWSRLLTAITTVFVKSKRPDMHDRKSKRPDMLMDSFGLESIVQEGLEFRQSFSIRSYEIGTDRTASIETLMNYLQETSLNHCKSTGILLDGFGRTPEMCKRDLIWVVTKMKIKVNRYPAWGDTVEINTWFSRLGKIGKGRDWLISDCNTGEILIRATSAYATMNQKTRRLSKLPYEVHQEIAPLFVDSPPVIEDNDLKLHKFEVKTGDSIHKGLTPGWNDLDVNQHVSNVKYIGWILESMPTEVLETQELCSLALEYRRECGRDSVLESVTAMDPTKVGGRSQYQHLLRLEDGTDIVKCRTEWRPKNPGANGAISTGKTSNGNSVS
서열 번호 89
쿠페아 아비게라 변이형 풀체리마(Ca) FATB1 부호화 DNA 서열
TCTCGCCCTTGAATATAGGCGGGAATGCGGAAGGGACAGTGTGCTAGAGTCCGTGACAGCTATGGATCCCACAAAAGTTGGAGGCCGGTCTCAGTACCAGCACCTTCTGCGACTTGAGGATGGGACTGATATCGTGAAGTGCAGAACTGAGTGGCGGCCGAAGAATCCAGGAGCTAATGGGGCAATATCAACGGGAAAGACTTCAAATGGAAACTCGGTCTCTTAG
서열 번호 90
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 아비게라 변이형 풀체리마(Ca) FATB1 부호화 DNA 서열
CCTGGCCCTGGAGTACCGCCGCGAGTGCGGCCGCGACTCCGTGCTGGAGTCCGTGACCGCCATGGACCCCACCAAGGTGGGCGGCCGCTCCCAGTACCAGCACCTGCTGCGCCTGGAGGACGGCACCGACATCGTGAAGTGCCGCACCGAGTGGCGCCCCAAGAACCCCGGCGCCAACGGCGCCATCTCCACCGGCAAGACCTCCAACGGCAACTCCGTGTCC
서열 번호 91
쿠페아 파우시페타라(Cpau) FATB1 아미노산 서열
MVAAAASSAFFPVPAPGTSPKPGKSGNWPSSLSPSIKPMSIPNGGFQVKANASAHPKANGSAVNLKSGSLNTQEDTSSSPPPRAFLNQLPDWSMLLTAITTVFVAAEKQWTMRDRKSKRPDMLVDSVGLKSVVLDGLVSRQIFSIRSYEIGADRTASIETLMNHLQETSINHCKSLGLLNDGFGRTPGMCKNDLIWVLTKMQIMVNRYPTWGDTVEINTWFSHSGKIGMASDWLITDCNTGEILIRATSVWAMMNQKTRRFSRLPYEVRQELTPHYVDSPHVIEDNDRKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVSNVKYIGWILESMPIEVLETQELCSLTVEYRRECGMDSVLESVTAMDPSEDEGRSQYKHLLRLEDGTDIVKGRTEWRPKNAGTNGAISTAKPSNGNSVS
서열 번호 92
쿠페아 파우시페타라(Cpau) FATB1 부호화 DNA 서열
CTCTCTCACCGTTGAATATAGGCGGGAATGCGGAATGGACAGTGTGCTGGAGTCCGTGACTGCTATGGATCCCTCAGAAGATGAAGGCCGGTCTCAGTACAAGCACCTTCTGCGGCTTGAGGATGGGACTGACATCGTGAAGGGCAGAACTGAGTGGCGACCGAAGAATGCAGGAACTAACGGGGCGATATCAACAGCAAAGCCTTCAAATGGAAACTCGGTCTCTTAG
서열 번호 93
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 파우시페타라(Cpau) FATB1 부호화 DNA 서열
CTCCCTGACCGTGGAGTACCGCCGCGAGTGCGGCATGGACTCCGTGCTGGAGTCCGTGACCGCCATGGACCCCTCCGAGGACGAGGGCCGCTCCCAGTACAAGCACCTGCTGCGCCTGGAGGACGGCACCGACATCGTGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCACCAACGGCGCCATCTCCACCGCCAAGCCCTCCAACGGCAACTCCGTGTCCTGA
서열 번호 94
쿠페아 프로컴벤스(Cproc) FATB1 아미노산 서열
MVAAAASSAFFPAPAPGSSPKPGKSGNWPSSLSPSFKSKSIPYGRFQVKANASAHPKANGSAVNLKSGSLNTQEDTSSSPPPRAFLNQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLVDSVGLKNIVRDGLVSRQSFLIRSYEIGADRTASIETLMNHLQETSINHCKSLGLLNDGFGRTPGMCKNDLIWVLTKMQIMVNRYPAWGDTVEINTWFSQSGKIGMGSDWLISDCNTGEILIRATSVWAMMNQKTRRFSRLPYEVRQELTPHFVDSPHVIEDNDRKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVSNVKYIGWILESMPIEVLEAQELCSLTVEYRRECGMDSVLESVTAVDPSEDGGRSQYNHLLRLEDGTDVVKGRTEWRPKNAETNGAISPGNTSNGNSIS
서열 번호 95
쿠페아 프로컴벤스(Cproc) FATB1 부호화 DNA 서열
CTCTCTCACCGTTGAATATAGGCGGGAATGCGGAATGGACAGTGTGCTGGAGTCCGTGACTGCTGTAGATCCCTCAGAAGATGGAGGCCGGTCTCAGTACAATCACCTTCTGCGGCTTGAGGATGGGACTGATGTCGTGAAGGGCAGAACTGAGTGGCGACCGAAGAATGCAGAAACTAACGGGGCGATATCACCAGGAAACACTTCAAATGGAAACTCGATCTCCTAG
서열 번호 96
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 프로컴벤스 (Cproc) FATB1 부호화 DNA 서열
CTCCCTGACCGTGGAGTACCGCCGCGAGTGCGGCATGGACTCCGTGCTGGAGTCCGTGACCGCCGTGGACCCCTCCGAGGACGGCGGCCGCTCCCAGTACAACCACCTGCTGCGCCTGGAGGACGGCACCGACGTGGTGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGAGACCAACGGCGCCATCTCCCCCGGCAACACCTCCAACGGCAACTCCATCTCCTGA
서열 번호 97
쿠페아 프로컴벤스(Cproc) FATB2 아미노산 서열
MVAAAASSAFFPAPAPGSSPKPGKSGNWPSSLSPSFKSKSIPYGRFQVKANASAHPKANGSAVNLKSGSLNTQEDTSSSPPPRAFLNQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLVDSVGLKNIVRDGLVSRQSFLIRSYEIGADRTASIETLMNHLQETSINHCKSLGLLNDGFGRTPGMCKNDLIWVLTKMQIMVNRYPAWGDTVEINTWFSQSGKIGMGSDWLISDCNTGEILIRATSVWAMMNQKTRRFSRLPYEVRQELTPHFVDSPHVIEDNDRKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRQECGRESVLESLTAVDPSGKGFGSQFQHLLRLEDGGEIVKGRTEWRPKTAGINGAIASGETSPGDF
서열 번호 98
쿠페아 프로컴벤스(Cproc) FATB2 부호화 DNA 서열
TTCCCTTACCCTGGAATACAGGCAGGAATGCGGAAGGGAGAGCGTGCTGGAGTCCCTCACTGCTGTGGACCCCTCTGGAAAGGGCTTTGGGTCCCAGTTCCAACACCTTCTGAGGCTTGAGGATGGAGGTGAGATCGTGAAGGGGAGAACTGAGTGGCGACCCAAGACTGCAGGTATCAATGGGGCGATAGCATCCGGGGAGACCTCACCTGGAGACTTTTAG
서열 번호 99
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 프로컴벤스(Cproc) FATB2 부호화 DNA 서열
CTCCCTGACCCTGGAGTACCGCCAGGAGTGCGGCCGCGAGTCCGTGCTGGAGTCCCTGACCGCCGTGGACCCCTCCGGCAAGGGCTTCGGCTCCCAGTTCCAGCACCTGCTGCGCCTGGAGGACGGCGGCGAGATCGTGAAGGGCCGCACCGAGTGGCGCCCCAAGACCGCCGGCATCAACGGCGCCATCGCCTCCGGCGAGACCTCCCCCGGCGACTTCTGA
서열 번호 100
쿠페아 프로컴벤스(Cproc) FATB3 아미노산 서열
MVAAAASSAFFPAPAPGSSPKPGKSGNWPSSLSPSFKSKSIPYGRFQVKANASAHPKANGSAVNLKSGSLNTQEDTSSSPPPRAFLNQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLVDSVGLKNIVRDGLVSRQSFLIRSYEIGADRTASIETLMNHLQETSINHCKSLGLLNDGFGRTPGMCKNDLIWVLTKMQIMVNRYPAWGDTVEINTWFSQSGKIGMGSDWLISDCNTGEILIRATSVWAMMNQKTRRFSRLPYEVRQELTPHFVDSPHVIEDNDRKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGEGGYGSQFQHLLRLEDGGEIVKGRTEWRPKNAGINGVLPTGE*
서열 번호 101
쿠페아 프로컴벤스(Cproc) FATB3 부호화 DNA 서열
TTCCCTTACCCTGGAATACAGGCGGGAATGTGGAAGGGAGAGCGTGCTGGAGTCCCTCACTGCTGTGGACCCCTCTGGAGAGGGGGGCTATGGATCCCAGTTTCAGCACCTTCTGCGGCTTGAGGATGGAGGTGAGATCGTGAAGGGGAGAACTGAGTGGCGACCCAAGAATGCTGGAATCAATGGGGTGTTACCAACCGGGGAGTAG
서열 번호 102
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 프로컴벤스(Cproc) FATB3 부호화 DNA 서열
CTCCCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGAGTCCGTGCTGGAGTCCCTGACCGCCGTGGACCCCTCCGGCGAGGGCGGCTACGGCTCCCAGTTCCAGCACCTGCTGCGCCTGGAGGACGGCGGCGAGATCGTGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCATCAACGGCGTGCTGCCCACCGGCGAGTGA
서열 번호 103
쿠페아 이그네아(Cignea) FATB1 아미노산 서열
PGTSRKTGKFGNWPSSLSPSFKPKSIPNGGFQVKANARAHPKANGSAVSLKSVSLNTQEDTSLSPPPRAFLNQLPDWRMLRTALTTVFVAAEKQWTMLDRKSKRPDMLVDSFGLESIVQEGLVFRQSFSIRSYEIGIDRTASIETLMNHLQETSLNQCKSAGILHDGFGRTLEMCKRDLIWVVTKMQIKVNRYPAWGDTVEISTRFSRLGKIGMGRDWLICDCNTGEILIRATSAYAMMNQKTRRLSKLPNEVRQEIAPLFVDSDPVIEENDMKLHKFEVKTGDSICKGLTPRWSDLDVNQHVSNVKYIGWILESMPTEVLETQELCSLALEYRRECGRDSVLESVTSMDPSKVGGWSQYQHLLRLEDGADIVKGRTEWRPKNAGANGAISTGKT
서열 번호 104
쿠페아 이그네아(Cignea) FATB1 부호화 DNA 서열
GCTGGAGTCTGTGACCTCTATGGATCCCTCAAAAGTTGGAGGCTGGTCTCAGTACCAGCACCTTCTGCGACTTGAGGATGGGGCGGATATCGTGAAGGGCAGAACTGAGTGGCGGCCGAAGAATGCAGGAGCTAACGGGGCGATATCAACAGGAAAGACTTGA
서열 번호 105
프로토테카 모리포르미스에 대해 코돈 최적화된 쿠페아 이그네아(Cignea) FATB1 부호화 DNA 서열
GCTGGAGTCCGTGACCTCCATGGACCCCTCCAAGGTGGGCGGCTGGTCCCAGTACCAGCACCTGCTGCGCCTGGAGGACGGCGCCGACATCGTGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCGCCAACGGCGCCATCTCCACCGGCAAGACCTGA
서열 번호 106
JcFatB1 공통 아미노산 서열
MVAAAASSAFFPVPAPGTSPKPGKSGNWPSSLSPSFKPKSIPNGGFQVKANASAHPKANGSAVNLKSGSLNTQEDTSSSPPPRAFLNQLPDWSMLLTAITTVFVAAEKQWTMLDRKSKRPDMLVDSVGLKRIVQDGLVSRQSFSIRSYEIGADRTASIETLMNHLQETSINHCKSLGLLNDGFGRTPGMCKNDLIWVLTKMQIMVNRYPTWGDTVEINTWFSQSGKIGMGSDWLISDCNTGEILIRATSVWAMMNQKTRRFSRLPYEVRQELTPHFVDSPHVIEDNDRKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVSNVKYIGWILESMPIEVLETQELCSLTVEYRRECGMDSVLESVTAMDPSENGGRSQYKHLLRLEDGTDIVKGRTEWRPKNAGTNGAISTGKTSNGNSVS*
서열 번호 107
프로토테카에 대해 코돈 최적화된 JcFatB1 공통 DNA 서열
CTCCCTGACCGTGGAGTACCGCCGCGAGTGCGGCATGGACTCCGTGCTGGAGTCCGTGACCGCCATGGACCCCTCCGAGAACGGCGGCCGCTCCCAGTACAAGCACCTGCTGCGCCTGGAGGACGGCACCGACATCGTGAAGGGCCGCACCGAGTGGCGCCCCAAGAACGCCGGCACCAACGGCGCCATCTCCACCGGCAAGACCTCCAACGGCAACTCCGTGTCCTGA
서열 번호 108
JcFatB2 공통 아미노산 서열
MVATAASSAFFPVPSPDTSSRPGKLGNGSSSLSPLKPKSVANGGLQVKANASAPPKINGSSVGLKSGSLKTQEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNDGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRHEIEPHFVDSAPVIEDDDRKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGKGYGSQFQHLLRLEDGGEIVKGRTEWRPKTAGINGAIASGETSPGDSS*
서열 번호 109
프로토테카에 대해 코돈 최적화된 JcFatB2 공통 DNA 서열
CCTGACCCTGGAGTACCGCCGCGAGTGCGGCCGCGAGTCCGTGCTGGAGTCCCTGACCGCCGTGGACCCCTCCGGCAAGGGCTACGGCTCCCAGTTCCAGCACCTGCTGCGCCTGGAGGACGGCGGCGAGATCGTGAAGGGCCGCACCGAGTGGCGCCCCAAGACCGCCGGCATCAACGGCGCCATCGCCTCCGGCGAGACCTCCCCCGGCGACTCCTCCTGA
서열 번호 110
CuPSR23 FATB3 아미노산 서열
MVVAAATSAFFPVPAPGTSPKPGKSGNWPSSLSPTFKPKSIPNAGFQVKANASAHPKANGSAVNLKSGSLNTQEDTSSSPPPRAFLNQLPDWSMLLTAITTVFVAAEKQWTMLDRKSKRPDMLVDSVGLKCIVRDGLVSRQSFLIRSYEIGADRTASIETLMNHLQETSINHCKSLGLLNDGFGRTPGMCKNDLIWVLTKMQIMVNRYPTWGDTVEINTWFSQSGKIGMASDWLISDCNTGEILIRATSVWAMMNQKTRRFSRLPYEVRQELTPHFVDSPHVIEDNDQKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVSNVKYIGWILESMPIEVLETQELCSLTVEYRRECGMDSVLESVTAVDPSENGGRSQYKHLLRLEDGTDIVKSRTEWRPKNAGTNGAISTSTAKTSNGNSVS
서열 번호 111
CuPSR23 FATB3b 아미노산 서열
MVVAAATSAFFPVPAPGTSPKPGKSGNWPSSLSPTFKPKSIPNAGFQVKANASAHPKANGSAVNLKSGSLNTQEDTSSSPPPRAFLNQLPDWSMLLTAITTVFVAAEKQWTMLDRKSKRPDMLVDSVGLKSIVRDGLVSRQSFLIRSYEIGADRTASIETLMNHLQETSINHCKSLGLLNDGFGRTPGMCKNDLIWVLTKMQIMVNRYPTWGDTVEINTWFSQSGKIGMASDWLISDCNTGEILIRATSVWAMMNQKTRRFSRLPYEVRQELTPHFVDSPHVIEDNDQKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVSNVKYIGWILESMPIEVLETQELCSLTVEYRRECGMDSVLESVTAVDPSENGGRSQYKHLLRLEDGTDIVKSRTEWRPKNAGTNGAISTSTAKTSNGNSAS
서열 번호 112
CwFATB3 아미노산 서열:
MVVAAAASSAFFPVPAPRTTPKPGKFGNWPSSLSPPFKPKSNPNGRFQVKANVSPHPKANGSAVSLKSGSLNTLEDPPSSPPPRTFLNQLPDWSRLRTAITTVFVAAEKQFTRLDRKSKRPDMLVDWFGSETIVQDGLVFRERFSIRSYEIGADRTASIETLMNHLQDTSLNHCKSVGLLNDGFGRTSEMCTRDLIWVLTKMQIVVNRYPTWGDTVEINSWFSQSGKIGMGRDWLISDCNTGEILVRATSAWAMMNQKTRRFSKLPCEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSICKGLTPGWNDLDVNQHVSNVKYIGWILESMPTEVLETQELCSLTLEYRRECGRESVVESVTSMNPSKVGDRSQYQHLLRLEDGADIMKGRTEWRPKNAGTNRAIST
서열 번호 113
CwFATB3a 아미노산 서열:
MVVAAAASSAFFPVPAPRTTPKPGKFGNWPSSLSPPFKPKSNPNGRFQVKANVSPHPKANGSAVSLKSGSLNTLEDPPSSPPPRTFLNQLPDWSRLRTAITTVFVAAEKQFTRLDRKSKRPDMLVDWFGSETIVQDGLVFRERFSIRSYEIGADRTASIETLMNHLQDTSLNHCKSVGLLNDGFGRTSEMCTRDLIWVLTKMQIVVNRYPTWGDTVEINSWFSQSGKIGMGRDWLISDCNTGEILVRATSAWAMMNQKTRRFSKLPCEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSICKGLTPGWNDLDVNQHVSNVKYIGWILESMPTEVLETQELCSLTLEYRRECGRESVVESVTSMNPSKVGDRSQYQHLLRLEDGADIMKGRTEWRPKNAGTNRAIST
서열 번호 114
CwFATB3b 아미노산 서열
MVVAAAASSAFFPVPAPRTTPKPGKFGNWPSSLSPPFKPKSNPNGRFQVKANVSPHPKANGSAVSLKSGSLNTLEDLPSSPPPRTFLNQLPDWSRLRTAITTVFVAAEKQFTRLDRKSKRPDMLVDWFGSETIVQDGLVFRERFSIRSYEIGADRTASIETLMNHLQDTSLNHCKSVGLLNDGFGRTSEMCTRDLIWVLTKMQIVVNRYPTWGDTVEINSWFSQSGKIGMGRDWLISDCNTGEILVRATSAWAMMNQKTRRFSKLPCEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSICKGLTPGWNDLDVNQHVSNVKYIGWILEKFWRPRSYALSPLNIGGNVEGKVW
서열 번호 115
CwFATB3c 아미노산 서열
MVVAAAASSAFFPVPAPRTTPKPGKFGNWPSSLSPPFKPKSNPNGRFQVKANVSPHPKANGSAVSLKSGSLNTLEDLPSSPPPRTFLNQLPDWSRLRTAITTVFVATEKQFTRLDRKSKRPDMLVDWFGSETIVQDGLVFRERFSIRSYEIGADRTASIETLMNHLQDTSLNHCKSVGLLNDGFGRTSEMCTRDLIWVLTKMQIVVNRYPTWGDTVEINSWFSQSGKIGMGRDWLISDCNTGEILVRATSAWAMMNQKTRRFSKLPCEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSICKGLTPGWNDLDVNQHVSNVKYIGWILEKFWRPRSYALSPLNIGGNVEGKVW
서열 번호 116
CwFATB4a 아미노산 서열
MVATAASSAFFPVPSADTSSSRPGKLGSGPSSLSPLKPKSIPNGGLQVKANASAPPKINGSSVGLKSGGFKTQEDSPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGSIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKIAGLSNDGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRNEIEPHFVDSAPVVEDDDRKLPKLDENTADSIRKGLTPRWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSAEGYASRFQHLLRLEDGGEIVKARTEWRPKNAGINGVVPSEESSPGDFF
서열 번호 117
CwFATB4a .1 아미노산 서열
MVATAASSAFFPVPSADTSSSRPGKLGSGPSSLSPLKPKSIPNGGLQVKANASAPPKINGSSVGLKSGGFKTQEDSPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGSIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKIAGLSNDGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRNEIEPHFVDSAPVVEDDDRKLPKLDENTADSIRKGLTPRWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSAEGYASRFQHLLRLEDGGEIVKARTEWRPKNAGINWVVPSEESSPGDFF
서열 번호 118
CwFATB4a .2 아미노산 서열:
MVATAASSAFFPVPSADTSSSRPGKLGNGPSSLSPLKPKSIPNGGLQVKANASAPPKINGSSVGLKSGSFKTQEDAPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGSIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKIAGLSNDGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRNEIEPHFVDSAPVVEDDDRKLPKLDENTADSIRKGLTPRWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSAEGYASRFQHLLRLEDGGEIVKARTEWRPKNAGINGVVPSEESSPGDFF
서열 번호 119
CwFATB4a .3 아미노산 서열
MVATAASSAFFPVPSADTSSSRPGKLGSGPSSLSPLKPKSIPNGGLQVKANASAPPKINGSSVGLKSGGFKTQEDSPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGSIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKIAGLSNDGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRNEIEPHFVDSAPVVEDDDRKLPKLDENTADSIRKGLTPRWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSAEGYVSRFQHLLRLEDGGEIVKARTEWRPKNAGINGVVPSEESSPGDFF
서열 번호 120
CwFATB4b 아미노산 서열
MVATAASSAFFPVPSADTSSSRPGKLGNGPSSLSPLKPKSIPNGGLQVKANASAPPKINGSSVGLKSGSFKTQEDAPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGSIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKIAGLSSDGFGRTPAMSKRDLIWVVAKMQVMVNRYPAWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRNEIEPHFVDSAPVVEDDDRKLPKLDENTADSIRKGLTPRWNDLDVNQHVNNVKYIGWILESTPAEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGEGDGSKFQHLLRLEDGGEIVKARTEWRPKNAGINGVVPSEESSPGGDFF
서열 번호 121
CwFATB4b .1 아미노산 서열
MVATAASSAFFPVPSADTSSSRPGKLGSGPSSLSPLKPKSIPNGGLQVKANASAPPKINGSSVGLKSGSFKTQEDAPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGSIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKIAGLSSDGFGRTPAMSKRDLIWVVAKMQVMVNRYPAWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRNEIEPHFVDSAPVVEDDDRKLPKLDENTADSIRKGLTPRWNDLDVNQHVNNVKYIGWILESTPAEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGEGDGSKFQHLLRLEDGGEIVKARTEWRPKNAGINGVVPSEESSPGGDFF
서열 번호 122
CwFATB5 아미노산 서열
MVAAAASSAFFSVPTPGTPPKPGKFGNWPSSLSVPFKPDNGGFHVKANASAHPKANGSAVNLKSGSLETPPRSFINQLPDLSVLLSKITTVFGAAEKQWKRPGMLVEPFGVDRIFQDGVFFRQSFSIRSYEIGVDRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKIQVEVNRYPTWGDTIEVNTWVSESGKNGMGRDWLISDCRTGEILIRATSVWAMMNQNTRRLSKFPYEVRQEIAPHFVDSAPVIEDDQKLQKLDVKTGDSIRDGLTPRWNDLDVNQHVNNVKYIGWILKSVPIEVFETQELCGVTLEYRRECGRDSVLESVTAMDPAKEGDRCVYQHLLRLEDGADITIGRTEWRPKNAGANGAMSSGKTSNGNCLIEGRGWQPFRVVRLIF
서열 번호 123
CwFATB5a 아미노산 서열
MVAAAASSAFFSVPTPGTPPKPGKFGNWPSSLSVPFKPDNGGFHVKANASAHPKANGSAVNLKSGSLETPPRSFINQLPDLSVLLSKITTVFGAAEKQWKRPGMLVEPFGVDRIFQDGFFFRQSFSIRSYEIGVDRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKIQVEVNRYPTWGDTIEVNTWVSESGKNGMGRDWLISDCRTGEILIRATSVWAMMNQNTRRLSKFPYEVRQEIAPHFVDSAPVIEDDQKLQKLDVKTGDSIRDGLTPRWNDLDVNQHVNNVKYIGWILKSVPIEVFETQELCGVTLEYRRECGRDSVLESVTAMDPAKEGDRCVYQHLLRLEDGADITIGRTEWRPKNAGANGAMSSGKTSNGNCLIEGRGWQPFRVVRLIF
서열 번호 124
CwFATB5b 아미노산 서열
MVAAAASSAFFSVPTPGTPPKPGKFGNWPSSLSVPFKPDNGGFHVKANASAHPKANGSAVNLKSGSLETPPRSFINQLPDLSVLLSKITTVFGAAEKQWKRPGMLVEPFGVDRIFQDGVFFRQSFSIRSYEIGVDRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKIQVEVNRYPTWGDTIEVNTWVSESGKNGMGRDWLISDCRTGEILIRATSVWAMMNQNTRRLSKFPYEVRQEIAPHFVDSAPVIEDDQKLQKLDVKTGDSIRDGLTPRWNDLDVNQHVNNVKYIGWILKSVPIEVFETQELCGVTLEYRRECGRDSVLESVTAMDPAKEGDRCVYQHLLWLEDGADITIGRTEWRPKNAGANGAMSSGKTSNGNCLIEGRGWQPFRVVRLIF
서열 번호 125
CwFATB5c 아미노산 서열
MVAAAASSAFFSVPTPGTPPKPGKFGNWPSSLSVPFKPDNGGFHVKANASAHPKANGSAVNLKSGSLETPPRSFINQLPDLSVLLSKITTVFGAAEKQWKRPGMLVEPFGVDRIFQDGVFFRQSFSIRSYEIGVDRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKIQVEVNRYPIWGDTIEVNTWVSESGKNGMGRDWLISDCRTGEILIRATSVWAMMNQNTRRLSKFPYEVRQEIAPHFVDSAPVIEDDQKLQKLDVKTGDSIRDGLTPRWNDLDVNQHVNNVKYIGWILKSVPIEVFETQELCGVTLEYRRECGRDSVLESVTAMDPAKEGDRCVYQHLLRLEDGADITIGRTEWRPKNAGANGAMSSGKTSNGNCLIEGMGWQPFRVVRLIF
서열 번호 126
CwFATB5 .1 아미노산 서열
MVAAAASSAFFSVPTPGTSPKPGKFRNWPSSLSVPFKPETNHNGGFHIKANASAHPKANGSALNLKSGSLETQEDTSLSSPPRTFIKQLPDWSMLLSKITTVFGAAEKQLKRPGMLVEPFGVDRIFQDGVFFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKIQVEVNRYPTWGDTIEVNTWVSESGKNGMGRDWLISDCRTGEILIRATSVWAMMNQNTRRLSKFPYEVRQEIAPHFVDSAPVIEDDRKLYKLNVKTGDSIRDGLTPRWNDLDVNQHVNNVKFIGWILKSVPTKVFETQELCGVTLEYRRECGKDSVLESVTAMDPAKEGDRSVYQHLLRLEDGADITIGRTEWRPKNAGANEAISSGKTSNGNSAS
서열 번호 127
CwFATB5 .1a 아미노산 서열
MVAAAASSAFFSVPTPGTSPKPGKFRNWPLSLSVPFKPETNHNGGFHIKANASAHPKANGSALNLKSGSLETQEDTSLSSPPRTFIKQLPDWSMLLSKITTVFGAAEKQLKRPGMLVEPFGVDRIFQDGVFFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKIQVEVNRYPTWGDTIEVNTWVSESGKNGMGRDWLISDCRTGEILIRATSVWAMMNQNTRRLSKFPYEVRQEIAPHFVDSAPVIEDDRKLYKLNVKTGDSIRDGLTPRWNDLDVNQHVNNVKFIGWILKSVPTKVFETQELCGVTLEYRRECGKDSVLESVTAMDPAKEGDRSVYQHLLRLEDGADITIGRTEWRPKNAGANEAISSGKTSNGNSAS
서열 번호 128
CcFATB2b 아미노산 서열
MVTTSLASAYFSMKAVMLAPDGRGIKPRSSGLQVRAGNERNSCKVINGTKVKDTEGLKGCSTLQGQSMLDDHFGLHGLVFRRTFAIRCYEVGPDRSTSIMAVMNHLQEAARNHAESLGLLGDGFGETLEMSKRDLIWVVRRTHVAVERYPAWGDTVEVEAWVGASGNTGMRRDFLVRDCKTGHILTRCTSVSVMMNMRTRRLSKIPQEVRAEIDPLFIEKVAVKEGEIKKLQKLNDSTADYIQGGWTPRWNDLDVNQHVNNIIYVGWIFKSVPDSISENHHLSSITLEYRRECIRGNKLQSLTTVCGGSSEAGIICEHLLQLEDGSEVLRARTEWRPKHTDSFQGISERFPQQEPHK
서열 번호 129
CcFATB3 아미노산 서열
MVATAAASAFFPVGAPATSSATSAKASMMPDNLDARGIKPKPASSSGLQVKANAHASPKINGSKVSTDTLKGEDTLTSSPAPRTFINQLPDWSMFLAAITTIFLAAEKQWTNLDWKPRRPDMLADPFGIGRFMQDGLIFRQHFAIRSYEIGADRTASIETLMNHLQETALNHVRSAGLLGDGFGATPEMSRRDLIWVVTRMQVLVDRYPAWGDIVEVETWVGASGKNGMRRDWLVRDSQTGEILTRATSVWVMMNKRTRRLSKLPEEVRGEIGPYFIEDVAIIEEDNRKLQKLNENTADNVRRGLTPRWSDLDVNQHVNNVKYIGWILESAPGSILESHELSCMTLEYRRECGKDSVLQSMTAVSGGGSAAGGSPESSVECDHLLQLESGPEVVRGRTEWRPKSANNSRSILEMPAESL
서열 번호 130
CcFATB3b 아미노산 서열
MVATAAASAFFPVGAPATSSATSAKASMMPDNLDARGIKPKLASSSGLQVKANAHASPKINGSKVSTDTLKGEDTLTSSPAPRTFINQLPDWSMFLAAITTIFLAAEKQWTNLDWKPRRPDMLADPFGIGRFMQDGLIFRQHFAIRSYEIGADRTASIETLMNHLQETALNHVRSAGLLGDGFGATPEMSRRDLIWVVTRMQVLVDRYPAWGDIVEVETWVGASGKNGMRRDWLVRDSQTGEILTRATSVWVMMNKRTRRLSKLPEEVRGEIGPYFIEDVAIIEEDNRKLQKLNENTADNVRRGLTPRWSDLDVNQHVNNVKYIGWILESAPGSILESHELSCMTLEYRRECGKDSVLQSMTAVSGGGSAAGGSPESSVECDHLLQLESGPEVVRGRTEWRPKSANNSRSILEMPAESL
서열 번호 131
CcFATB3c 아미노산 서열
MVATAAASAFFPVGAPATSSATSAKASMMPDNLDARGIKPKPASSSGLQVKANAHASPKINGSKVSTDTLKGEDTLTSSPAPRTFINQLPDWSMFLAAITTIFLAAEKQWTNLDWKPRRPDMLADPFGIGRFMQDGLIFRQHFAIRSYEIGADRTASIETLMNHLQETALNHVRSAGLLGDGFGATPEMSRRDLIWVVTRMQVLVDRYPAWGDIVEVETWVGASGKNGMRRDWLVRDSQTGEILTRATSVWVMMNKRTRRLSKLPEEVRGEIGPYFIEDVAIIEEDNRKLQKLNENTADNVRRGLTPRWSDLDVNQHVNNAKYIGWILESAPGSILESHELSCMTLEYRRECGKDSVLQSMTAVSGGGSAAGGSPESSVECDHLLQLESGPEVVRGRTEWRPKSANNSRSILEMPAESL
서열 번호 132
ChtFATB1a 아미노산 서열
MVAAAASSAFFSVPTPGTSTKPGNFGNWPSSLSVPFKPESNHNGGFRVKANASAHPKANGSAVNLKSGSLETQEDTSSSSPPPRTFIKQLPDWGMLLSKITTVFGAAERQWKRPGMLVEPFGVDRIFQDGVFFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKIQVEVNRYPTWGDTIEVNTWVSESGKNGMGRDWLISDCRTGEILIRATSVWAMMNRKTRRLSKFPYEVRQEIAPHFVDSAPVIEDDKKLHKLDVKTGDSIRKGLTPRWNDLDVNQHVNNVKYIGWILKSVPAEVFETQELCGVTLEYRRECGRDSVLESVTAMDTAKEGDRSLYQHLLRLEDGADITIGRTEWRPKNAGANGAISTGKTSNENSVS
서열 번호 133
ChtFATB1a .1 아미노산 서열
MVAAAASSAFFSVPTPGTSPKPGNFGNWPSSLSVPFKPESNHNGGFRVKANASAHPKANGSAVNLKSGSLETQEDTSSSSPPPRTFIKQLPDWGMLLSKITTVFGAAERQWKRPGMLVEPFGVDRIFQDGVFFRHSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKIQVEVNRYPTWGDTIEVNTWVSESGKNGMGRDWLIGDCRTGEILIRATSVWAMMNRKTRRLSKFPYEVRQEIAPHFVDSAPVIEDDKKLHKLDVKTGDSIRKGLTPRWNDLDVNQHVNNVKYIGWILKSVPAEVFETQELCGVTLEYRRECGRDSVLESVTAMDTAKEGDRSLYQHLLRLEDGADITIGRTEWRPKNAGANGALSTGKTSNGNSVS
서열 번호 134
ChtFATB1a .2 아미노산 서열
MVAAAASSAFFSVPTPGTSPKPGNFGNWPSNLSVPFKPESNHNGGFRVKANASAHPKANGSAVNLKSGSLETQEDTSSSSPPPRTFIKQLPDWGMLLSKITTVFGAAERQWKRPGMLVEPFGVDRIFQDGVFFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKIQVEVNRYPTWGDTIEVNTWVSESGKNGMGRDWLISDCRTGEILIRATSVWAMMNRKTRRLSKFPYEVRQEIAPHFVDSAPVIEDDKKLHKLDVKTGDSIRKGLTPRWNDFDVNQHVNNVKYIGWILKSVPAEVFETQELCGVTLEYRRECGRDSVLESVTAMDTAKEGDRSLYQHLLRLEDGADITIGRTEWRPKNAGANGAISTGKTSNENSVS
서열 번호 135
ChtFATB1a .3 아미노산 서열
MVAAAASSAFFSVPTPGTSPKPGNFGNWPSSLSVPFKPESNHNGGFRVKANASAHPKANGSAVNLKSGSLETQEDTSSSSPPPRTFIKQLPDWGMLLSKITTVFGAAERQWKRPGMLVEPFGVDRIFQDGVFFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKIQVEVNRYPTWGDTIEVNTWVSESGKNGMGRDWLISDCRTGEILIRATSVWAMMNRKTRRLSKFPYEVRQEIAPHFVDSAPVIEDDKKLHKLDVKTGDSIRKGLTPRWNDFDVNQHVNNVKYIGWILKSVPAEVFETQELCGVTLEYRRECGRDSVLESVTAMDTAKEGDRSLYQHLLRLEDGADITIGRTEWRPKNAGVNGAISTGKTSNENSVS
서열 번호 136
ChtFATB1a .4 아미노산 서열
MVAAAASSAFFSVPTPGTSPKPGNFGNWPSSLSVPFKPESNHNGGFRVKANASAHPKANGSAVNLKSGSLETQEDTSSSSPPPRTFIKQLPDWSMLLSKITTVFGAAERQWKRPGMLVEPFGVDRIFQDGVFFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKIQVEVNRYPTWGDTIEVNTWVSESGKNGMGRDWLISDCRTGEILIRATSVWAMMNRKTRRLSKFPYEVRQEIAPHFVDSAPVIEDDKKLHKLDVKTGDSIRKGLTPRWNDFDVNQHVNNVKYIGWILKSVPAEVFETQELCGVTLEYRRECGRDSVLESVTAMDTAKEGDRSLYQHLLRLEDGADITIGRTEWRPKNAGANGAISTGKTSNENSVS
서열 번호 137
ChtFATB1b 아미노산 서열
MVAAAASSAFFSVPTSGTSPKPGNFGNWPSSLSVPFKPESSHNGGFQVKANASAHPKANGSAVNLKSGSLETQEDTSSSSPPPRTFIKQLPDWSMLLSKITTVFWAAERQWKRPGMLVEPFGVDRIFQDGVFFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKIQVEVNRYPTWGDTIEVNTWVSESGKNGMGRDWLISDCRTGEILIRATSVWAMMNRKTRRLSKFPYEVRQEIAPHFVDSAPVIEDDKKLHKLDVKTGDFIRKGLTPRWNDFDVNQHVNNVKYIGWILKSVPAEVFETQELCGVTLEYRRECGRDSVLESVTAMDTAKEGDRSLYQHLLRLEDGADITIGRTEWRPKNAGANGAISTGKTSNENSVS
서열 번호 138
ChtFATB2b 아미노산 서열
MVVAAAASSAFFPVPASGTSPKPGKFGTWLSSSSPSYKPKSNPSGGFQVKANASAHPKANGSAVSLKSGSLNTQEGTSSSPPPRTFLNQLPDWSRLRTAITTVFVAAEKQLTMLDRKSKKPDMHVDWFGLEIIVQDGLVFRESFSIRSYEIGADRTASIETLMNHLQDTSLNHCKSVGLLNDGFGRTPEMCKRDLIWVLTKMQIMVNRYPTWGDTVEINSWFSQSGKIGMGRNWLISDCNTGEILIRATSIWAMMNQKTRRFSKLPNEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSICKGLTPEWNDLDVNQHVSNVKYIGWILESMPKEVLDTQELCSLTLEYRRECGRDSVLESVTAMDPSKVGDRSQYQHLLRLEDGTDIMKGRTEWRPKNAGTNGAISTGKTSNGNSVS
서열 번호 139
ChtFATB2a 아미노산 서열
MVVAAAASSAFFPVPAPGTTSKPGKFGNWPSSLSPSFKPKSNPNGGFQVKANASAHPKANGSAVSLKSGSLNTKEDTPSSPPPRTFLNQLPDWSRLRTAITTVFVAAEKQLTMLDRKSKKPDMHVDWFGLEIIVQDWLVFRESFSIRSYEIGADRTASIETLMNHLQDTSLNHCKSVGLLNDGFGRTPEMCKRDLIWVLTKMQIMVNRYPTWGDTVEINSWFSQSGKIGMGRNWLISDCNTGEILIRATSIWAMMNQKTRRFSKLPNEVRQEIAPHFVDAPPLIEDNDRKLHKFDVKTGDSICKGLTPEWNDLDVNQHVSNVKYIGWILESMPKEVLDTQELCSLTLEYRRECGRDSVLESVTAMDPSKVGDRSQYQHLLRLEDGTDIMKGRTEWRPKNAGTNGAISTGKTSNGNSVS
서열 번호 140
ChtFATB2c 아미노산 서열
MVVAAAASSAFFPVPASGTSPKPGKFGTWLSSSSPSYKPKSNPSGGFQVKANASAHPKANGSAVSLKSGSLNTKEDTPSSPPPRTFLNQLPDWNRLRTAITTVFVAAEKQLTMLDRKSKKPDMHVDWFGLEIIVQDGLVFRESFSIRSYEIGADRTASIETLMNHLQDTSLNHCKSVGLLNDGFGRTPEMCKRDLIWVLTKMQIMVNRYPTWGDTVEINSWFSQSGKIGMGRNWLISDCNTGEILIRATSIWAMMNQKTRRFSKLPNEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSICKGLTPEWNDLDVNQHVSNVKYIGWILESMPKEVLDTQELCSLTLEYRRECGRDSVLESVTAMDPSKVGDRSQYQHLLRLEDGTDIMKGRTEWRPKNAGTNGAISTGKTSNGNSVS
서열 번호 141
ChtFATB2d 아미노산 서열
MVVAAAASSAFFPVPAPGTTSKPGKFGNWPSSLSPSFKPKSNPNGGFQVKANASAHPKANGSAVSLKSGSLNTQEDTSSSPPPRTFLNQLPDWSRLLTAISTVFVAAEKQLTMLDRKSKRPDMLVDLFGLESIVQDGLVFRESYSIRSYEIGADRTASIETLMNHLQDTSLNHCKSVGLLNDGFGRTPEMCKRDLIWVLTKMQIMVNRYPTWGDTVEINSWFSQSGKIGMGRNWLISDCNTGEILIRATSIWAMMNQNTRRFSKLPNEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSIRKGLTPGWNDLDVNQHVSNVKYIGWILESMPTEVLETQELCSLTLEYRRECGRESVLESVTAMNPSKVGDRSQYQHLLRLEDGADIMKGRTEWRPKNAGTNGAISTGKTSNGNSVS
서열 번호 142
ChtFATB2e 아미노산 서열
MVVAAAASSAFFPVPASGTSPKPGKFGTWLSSSSPSYKPKSNPSGGFQVKANASAHPKANGSAVSLKSGSLNTQEDTSSSPPPQTFLNQLPDWSRLLTAISTVFVAAEKQLTMLDRKSKRPDMLVDWFGLESIVQDGLVFRESYSIRSYEISADRTASIETVMNLLQETSLNHCKSMGILNDGFGRTPEMCKRDLIWVLTKMQILVNRYPNWGDTVEINSWFSQSGKIGMGRNWLISDCNTGEILIRATSIWAMMNQNTRRFSKLPNEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSIRKGLTPGWNDLDVNQHVSNVKYIGWILESMPTEVLETQELCSLTLEYRRECGRDSVLESVTAMNPSKVGDRSQYQHLLRLEDGADIMKGRTEWRPKNAGTNGAISTGKTSNGNSVS
서열 번호 143
ChtFATB2f 아미노산 서열
MVVAAAASSAFFPVPASGTSPKPGKFGTWLSSSSPSYKPKSNPSGGFQVKANASAHPKANGSAVSLKSGSLNTQEGTSSSPPPRTFLNQLPDWSRLLTAISTVFVAAEKQLTMLDRKSKRPDMLVDWFGLESIVQDGLVFRESYSIRSYEISADRTASIETVMNLLQETSLNHCKSMGILNDGFGRTPEMCKRDLIWVLTKMQILVNRYPNWGDTVEINSWFSQSGKIGMGRNWLISDCNTGEILIRATSIWAMMNQKTRRFSKLPNEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSICKGLTPEWNDLDVNQHVSNVKYIGWILESMPKEVLDTQELCSLTLEYRRECGRDSVLESVTAMDPSKVGDRSQYQHLLRLEDGTDIMKGRTEWRPKNAGTNGAISTGKTSNGNSVS
서열 번호 144
ChtFATB2g 아미노산 서열
MVVAATASSAFFPVPVPGTSPKPGKFGTWLSSSSPSYKPKSNPSGGFQVKANASAHPKANGSAVSLKSGSLNTQEDTSSSPPPRTFLNQLPDWSRLLTAISTVFVAAEKQLTMLDRKSKRPDMLVDWFGLESIVQDGLVFREIYSIRSYEISADRTTSIETVMNLLQETSLNHCKSMGILNDGFGRTPEMCKRDLIWVLTKMQILVNRYPNWGDTVEINSWFSQSGKIGMGRNWLISDCNTGEILIRATSIWAMMNQKTRRFSKLPNEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSICKGLTPEWNDLDVNQHVSNVKYIGWILESMPKEVLDTQELCSLTLEYRRECGRDSVLESVTAMDPSKVGDRSQYQHLLRLEDGTDIMKGRTEWRPKNAGTNGAISTGKTSNANSVS
서열 번호 145
ChtFATB2h 아미노산 서열
MVVAAAASSAFFPVPASGTSPKPGKFGTWLSSSSPSYKPKSNPSGGFQVKANASAHPKANGSAVSLKSGSLNTQEGTSSSPPPRTFLNQLPDWSRLLTAISTVFVAAEKQLTMLDRKSKRPDMLVDWFGLESIVQDGLVFRESYSIRSYEISADRTASIETVMNLLQETSLNHCKSMGILNDGFGRTPEMCKRDLIWVLTKMQILVNRYPNWGDTVEINSWFSQSGKIGMGRNWLISDCNTGEILIRATSIWAMMNQNTRRFSKLPNEVRQEIAPHFVDAPPVIEDNDRKLHKFDVKTGDSIRKGLTPGWNDLDVNQHVSNVKYIGWILESIPTEVLETQELCSLTLEYRRECGRESVLESVTAMNPSKVGDRSQYQHLLRLEDGADIMKGRTEWRPKNAGTNGAISTGKTSNGNSVS
서열 번호 146
ChtFATB3a 아미노산 서열
MVATAASSAFFPVPSPDTSSRPGKLGNGSSSLRPLKPKFVANAGLQVKANASAPPKINGSSVSLKSCSLKTHEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNEGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRKLSKIPDEVRHEIEPHFVDSAPVIEDDDWKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGKGFGPQFQHLLRLEDGGEIVKGRTEWRPKTAGINGTIASGETSPGNS
서열 번호 147
ChtFATB3b 아미노산 서열
MVATAASSAFFPVPSPDTSSRPGKLGNGSSSLRPLKPKFVANAGLQVKANASAPPKINGSSVSLKSGSLKTQEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGFGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLIEGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRKLSKIPDEVRHEIEPHFVDSAPVIEDDDWKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGKGFGPQFQHLLRLEDGGEIVKGRTEWRPKTAGINGTIASGETSPGNS
서열 번호 148
ChtFATB3c 아미노산 서열
MVATAASSAFFPVPSPDTSSRPGKLGNGSSSLRPLKPKFVANAGLQVKANASAPPKINGSSVSLKSCSLKTHEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNEGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRKLSKIPDEVRHEIEPHFVDSAPVIEDDDRKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSEKGFGPQFQHLLRLEDGGEIVKGRTEWRPKTAGINGAIAFGETSPGDS
서열 번호 149
ChtFATB3d 아미노산 서열
MVATAASSAFFPVPSPDTSSRPGKLGNGSSSLRPLKPKFVANAGLQVKANASAPPKINGSSVSLKSCSLKTHEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIKTVMNHLQETALNHVKSAGLLNEGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRKLSKIPDEVRHEIEPHFVDSAPVIEDDDWKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGKGFGPQFQHLLRLEDGGEIVKGRTEWRPKTAGINGTIASGETSPGNS
서열 번호 150
ChtFATB3e 아미노산 서열
MVATAASSAFFPVPSPDTSSRPGKLGNGSSSLRPLKPKFVANAGLQVKANASAPPKINGSSVSLKSGSLKTHEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNEGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRKLSKIPDEVRHEIEPHFVDSAPVIEDDDWKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGKGFGPQFQHLLRLEDGGEIVKGRTEWRPKTAGINGTIASGETSPGNS
서열 번호 151
ChtFATB3f 아미노산 서열
MVATAASSAFFPVPSPDTSSRLGKLGNGSSSLRPLKPKFVANAGLQVKANASAPPKINGSSVSLKSGSLKTQEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMPVDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNEGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRKLSKIPDEVRHEIEPHFVDSAPVIEDDDWKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSEKGFGPQFQHLLRLEDGGEIVKGRTEWRPKTAGINGTIASGETSPGNS
서열 번호 152
ChtFATB3g 아미노산 서열
MVATAASSAFFPVPSPDTSSRAGKLGNGSSSLRPLKPKFVANAGLQVKANASAPPKINGSSVSLKSGSLKTQEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNEGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRKLSKIPDEVRHEIEPHFVDSAPVIEDDDWKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGKGFGPQFQHLLRLEDGGEIVKGRTEWRPKTAGINGTIASGETSPGNS
서열 번호 153
ChsFATB1 아미노산 서열
MVATNAAAFSAYTFFLTSPTHGYSSKRLADTQNGYPGTSLKSKSTPPPAAAAARNGALPLLASICKCPKKADGSMQLDSSLVFGFQFYIRSYEVGADQTVSIQTVLNYLQEAAINHVQSAGYFGDSFGATPEMTKRNLIWVITKMQVLVDRYPAWGDVVQVDTWTCSSGKNSMQRDWFVRDLKTGDIITRASSVWVLMNRLTRKLSKIPEAVLEEAKLFVMNTAPTVDDNRKLPKLDGSSADYVLSGLTPRWSDLDMNQHVNNVKYIAWILESVPQSIPETHKLSAITVEYRRECGKNSVLQSLTNVSGDGITCGNSIIECHHLLQLETGPEILLARTEWISKEPGFRGAPIQAEKVYNNK
서열 번호 154
ChsFATB2 아미노산 서열
MVATAASSAFFPVPSPDASSRPGKLGNGSSSLSPLKPKLMANGGLQVKANASAPPKINGSSVGLKSGSLKTQEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNDGFGRTLEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRHEIEPHFVDSAPVIEDDDRKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGKGSGSQFQHLLRLEDGGEIVKGRTEWRPKTAGINGPIASGETSPGDSS
서열 번호 155
ChsFatB2b 아미노산 서열
MVATAASSAFFPVPSPDASSRPGKLGNGSSSLSPLKPKLMANGGLQVKANASAPPKINGSSVGLKSGSLKTQEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNDGFGRTLEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSKSQIMLPLHYCSVWVMMNQKTRRLSKIPDEVRHEIEPHFVDSAPVIEDDDRKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGKGSGSQFQHLLRLEDGGEIVKGRTEWRPKTAGINGPIASGETSPGDSS
서열 번호 156
ChsFatB2c 아미노산 서열
MVATAASSAFFPVPSPDASSRPGKLGNGSSSLSPLKPKLMANGGLQVKANASAPPKINGSSVGLKSGSLKTQEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNDGFGRTLEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRHEIEPHFVDSAPVIEDDDRKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGKGSGSQFQHLMRLEDGGEIVKGRTEWRPKTAGINGPIASGETSPGDSS
서열 번호 157
ChsFatB2d 아미노산 서열
MVATAASSAFFPVPSPDASSRPGKLGNGSSSLSPLKPKLMANGGLQVKANASAPPKINGSSVGLKSGSLKTQEDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLVDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNDGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRHEIEPHFVDSAPVIEDDDRKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGKGSGSQFQHLLRLEDGGEIVKGRTEWRPKTAGINGPIASGETSPGDSS
서열 번호 158
Chs FATB3 아미노산 서열
MVAAEASSALFSVRTPGTSPKPGKFGNWPTSLSVPFKSKSNHNGGFQVKANASARPKANGSAVSLKSGSLDTQEDTSSSSSPPRTFINQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLMDPFGVDRVVQDGAVFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKMHVEVNRYPTWGDTIEVNTWVSESGKTGMGRDWLISDCHTGEILIRATSMCAMMNQKTRRFSKFPYEVRQELAPHFVDSAPVIEDYQKLHKLDVKTGDSICNGLTPRWNDLDVNQHVNNVKYIGWILESVPTEVFETQELCGLTLEYRRECGRDSVLESVTAMDPSKEGDRSLYQHLLRLEDGADIAKGRTKWRPKNAGTNGAISTGKTSNGNSIS
서열 번호 159
ChsFatb3b 아미노산 서열
MVAAEASSALFSVRTPGTSPKPGKFGNWPTSLSVPFKSKSNHNGGFQVKANASARPKANGSAVSLKSGSLDTQEDTSSSSSPPRTFINQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLMDPFGVDRVVQDGAVFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKMHIEVNRYPTWGDTIEVNTWVSESGKTGMGRDWLISDFHTGDILIRATSVCAMMNQKTRRFSKFPYEVRQELAPHFVDSAPVIEDYQKLHKLDVKTGDSICNGLTPRWNDLDVNQHVNNVKYIGWILESVPTEVFETQELCGLTLEYRRECGRDSVLESVTAMDPSKEGDRSLYQHLLRLEDGADIAKGRTKWRPKNAGTNGAISTGKTSNGNSIS
서열 번호 160
ChsFatB3c 아미노산 서열
MVAAEASSALFSVRTPGTSPKPGKFGNWPTSLSVPFKSKSNHNGGFQVKANASARPKANGSAVSLKSGSLDTQEDTSSSSSPPRTFINQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLMDPFGVDRVVQDGAVFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKMHVEVNRYPTWGDTIEVNTWVSESGKTGMGRDWLISDCHTGEILIRATSMCAMMNQKTRRFSKFPYEVRQELAPHFVDSAPVIEDYQKLHKLDVKTGDSICNGLTPRWNDLDVNQHVNNVKYIGWILESVPTEVFETQELCGLTLEYRQECGRDSVLESVTAMDPSKEGDRSLYQHLLRLEDGTDIAKGRTKWRPKNAGKTSNGNSIS
서열 번호 161
ChsFATB3d 아미노산 서열
MVAAEASSALFSVRTPGTSPKPGKFGNWPSSLSVPFKSKSNHNGGFQVKANASARPKANGSAVSLKSGSLDTQEDASSSSSPPRTFINQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRSDMLMDPFGVDRVVQDGAVFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKMHVEVNRYPTWGDTIEVNTWVSESGKTGMGRDWLISDCHTGEILIRATSMCAMMNQKTRRFSKFPYEVRQELAPHFVDSAPVIEDYQKLHKLDVKTGDSICNGLTPRWNDLDVNQHVNNVKYIGWILESVPTEVFETQELCGLTLEYRRECGRDSVLESVTAMDPSKEGDRSLYQHLLRLEDGADIAKGRTKWRPKNAGTNGAISTGKTSNGNSIS
서열 번호 162
ChsFATB3e 아미노산 서열
MVAAEASSALFSVRTPGTSPKPGKFGNWPSSLSVPFKSKSNHNGGFQVKANASARPKANGSAVSLKSGSLDTQEDASSSSSPPRTFINQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRSDMLMDPFGVDRVVQDGVVFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKMHVEVNRYPTWGDTIEVNTWVSESGKTGMGRDWLISDCHTGEILIRATSMCAMMNQKTRRFSKFPYEVRQELAPHFVDSAPVIEDYQKLHKLDVKTGDSICNGLTPRWNDLDVNQHVNNVKYIGWILESVPTEVFETQELCGLTLEYRRECGRDSVLESVTAMDPSKEGDRSLYQHLLRLEDGADIAKGRTKWRPKNAGTNGAISTGKTSNGNSIS
서열 번호 163
ChsFATB3f 아미노산 서열
MVAAEASSALFSVRTPGTSPKPGKFGNWPSSLSVPFKSKSNHNGGFQVKANASARPKANGSAVSLKSGSLDTQEDTSSSSSPPRTFINQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLMDPFGVDRVVQDGAVFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKMHVEVNRYPTWGDTIEVNTWVSESGKTGMGRDWLISDCHTGEILIRATSMCAMMNQKTRRFSKFPYEVRQELAPHFVDSAPVIEDYQKLHKLDVKTGDSICNGLTPRWNDLDVNQHVNNVKYIGWILESVPTEVFETQELCGLTLEYRRECGRDSVLESVTAMDPSKEGDRSLYQHLLRLEDGADIAKGRTKWRPKNAGTNGAISTGKTSNGNSIS
서열 번호 164
ChsFATB3g 아미노산 서열
MVAAEASSALFSVRTPGTSPKPGKFGNWPTSLSVPFKSKSNHNGGFQVKANASARPKANGSAVSLKSGSLDTQEDTSSSSSPPRTFINQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLMDPFGVDRVVQDGAVFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKMHIEVNRYPTWGDTIEVNTWVSESGKTGMGRDWLISDFHTGDILIRATSVCAMMNQKTRRFSKFPYEVRQELAPHFVDSAPVIEDYQKLHKLDVKTGDSICNGLTPRWNDLDVNQHVNNVKYIGWILESVPTEVFETQELCGLTLEYRQECGRDSVLESVTAMDPSKEGDRSLYQHLLRLEDGTDIAKGRTKWRPKNAGKTSNGNSIS
서열 번호 165
ChsFATB3h 아미노산 서열
MVAAEASSALFSVRTPGTSPKPGKFGNWPSSLSVPFKSKSNHNGGFQVKANASARPKANGSAVSLKSGSLDTQEDASSSSSPPRTFINQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRSDMLMDPFGVDRVVQDGVVFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKMHIEVNRYPTWGDTIEVNTWVSESGKTGMGRDWLISDFHTGDILIRATSVCAMMNQKTRRFSKFPYEVRQELAPHFVDSAPVIEDYQKLHKLDVKTGDSICNGLTPRWNDLDVNQHVNNVKYIGWILESVPTEVFETQELCGLTLEYRQECGRDSVLESVTAMDPSKEGDRSLYQHLLRLEDGTDIAKGRTKWRPKNAGKTSNGNSIS
서열 번호 166
ChsFATB3i 아미노산 서열
MVAAEASSALFSVRTPGTSPKPGKFGNWPTSLSVPFKSKSNHNGGFQVKANASARPKANGSAVSLKSGSLDTQEDTSSSSSPPRTFINQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLMDPFGVDRVVQDGAVFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKMHVEVNRYPTWGDTIEVNTWVSESGKTGMGRDWLISDCHTGEILIRATSMCAMMNQKTRRFSKFPYEVRQELAPHFVDSAPVIEDYQKLHKLDVKTGDSICNGLTPRWNDLDVNQHVNNVKYIGWILESVPTEVFETQELCGLTLEYRRECGGDSVLESVTAMDPSKEGDRSLYQHLLRLEDGADIAKGRTKWRPKNAGTNGAISTGKTSNGNSIS
서열 번호 167
ChsFATB3j 아미노산 서열
MVAAEASSALFSVRTPGTSPKPGKFGNWPTSLSVPFKSKSNHNGGFQVKANASARPKANGSAVSLKSGSLDTQEDTSSSSSPPRTFINQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLMDPFGVDRVVQDGAVFRQSFSIRSYEIGADRTASIETLMNIFQETSLNHCKSIGLLNDGFGRTPEMCKRDLIWVVTKMHIEVNRYPTWGDTIEVNTWVSESGKTGMGRDWLISDFHTGDILIRATSVCAMMNQKTRRFSKFPYEVRQELAPHFVDSAPVIEDYQKLHKLDVKTGDSICNGLTPRWNDLDVNQHVNNVKYIGWILESVPTEVFETQELCGLTLEYRQECGRDSVLESVTAMDPSKEGDRSLYQHLLRLEDGTDIAKGRTKWRPKNAGKTSNGNSIS
서열 번호 168
CcalcFATB1 (쿠페아 칼카라타 FATB1)
MVAAAATSAFFPVPAPGTSPNPRKFGSWPSSLSPSLPKSIPNGGFQVKANASAHPKANGSAVSLKSGSLNTQENTSSSPPPRTFLHQLPDWSRLLTAITTVFVKSKRPDMHDRKSKRPDMLVDLFGLESSVQDALVFRQSFSIRSYEIGTDRTASIETLMNHLQETSLNHCKSTGILLDGFGRTLEMCKRELIWVVIKMQIQVNRYPAWGDTVEINTRFSRLGKIGMGRDWLISDCNTGEILIRATSEYAMMNQKTRRLSKLPYEVHQEIAPLFVDSPPVIEDNDLKVHKFEVKTGDSIQKGLSPGWNDLDVNQHVSNVKYIGWILESMPTEVLETQELCSLALEYRRECGRDSVLESVTAMDPSKVGGRSQYQHLLRLEDGTAIVNGITEWRPKNAGANGAISTGKTSNGNSVS
서열 번호 169
ChookFATB4 (쿠페아 후케리아나 FATB4)
MVAAAATSAFFPVPAPGTSPNPRKFGSWPSSLSPSLPNSIPNGGFQVKANASAHPKANGSAVSLKSGSLNTQENTSSSPPPRTFLHQLPDWSRLLTAITTVFVKSKRPDMHDRKSKRPDMLVDLFGLESSVQDALVFRQRFSIRSYEIGTDRTASMETLMNHLQETSLNHCKSTGILLDGFGRTLEMCKRELIWVVIKMQIQVNRYPAWGDTVEINTRFSRLGKIGMGRDWLISDCNTGEILIRATSEYAMMNQKTRRLSKLPYEVRQEIAPLFVDSPPVIEDNDLKVHKFEVKTGDSIHKGLTPGWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAMDPSGGGYGSQFQHLLRLEDGGEIVKGRTEWRPKNGVINGVVPTGESSPGDYS
서열 번호 170
CaFATB1 (쿠페아 아비게라 변이형 풀체리마 FATB1)
MVAAAASSAFFSVPVPGTSPKPGKFRIWPSSLSPSFKPKPIPNGGLQVKANSRAHPKANGSAVSLKSGSLNTQEDTSSSPPPRTFLHQLPDWSRLLTAITTVFVKSKRPDMHDRKSKRPDMLMDSFGLESIVQEGLEFRQSFSIRSYEIGTDRTASIETLMNYLQETSLNHCKSTGILLDGFGRTPEMCKRDLIWVVTKMKIKVNRYPAWGDTVEINTWFSRLGKIGKGRDWLISDCNTGEILIRATSAYATMNQKTRRLSKLPYEVHQEIAPLFVDSPPVIEDNDLKLHKFEVKTGDSIHKGLTPGWNDLDVNQHVSNVKYIGWILESMPTEVLETQELCSLALEYRRECGRDSVLESVTAMDPTKVGGRSQYQHLLRLEDGTDIVKCRTEWRPKNPGANGAISTGKTSNGNSVS
서열 번호 171
CpauFATB1 (쿠페아 파우시페타라 FATB1)
MVAAAASSAFFPVPAPGTSPKPGKSGNWPSSLSPSIKPMSIPNGGFQVKANASAHPKANGSAVNLKSGSLNTQEDTSSSPPPRAFLNQLPDWSMLLTAITTVFVAAEKQWTMRDRKSKRPDMLVDSVGLKSVVLDGLVSRQIFSIRSYEIGADRTASIETLMNHLQETSINHCKSLGLLNDGFGRTPGMCKNDLIWVLTKMQIMVNRYPTWGDTVEINTWFSHSGKIGMASDWLITDCNTGEILIRATSVWAMMNQKTRRFSRLPYEVRQELTPHYVDSPHVIEDNDRKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVSNVKYIGWILESMPIEVLETQELCSLTVEYRRECGMDSVLESVTAMDPSEDEGRSQYKHLLRLEDGTDIVKGRTEWRPKNAGTNGAISTAKPSNGNSVS
서열 번호 172
CprocFATB1 (쿠페아 프로컴벤스 FATB1)
MVAAAASSAFFPAPAPGSSPKPGKSGNWPSSLSPSFKSKSIPYGRFQVKANASAHPKANGSAVNLKSGSLNTQEDTSSSPPPRAFLNQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLVDSVGLKNIVRDGLVSRQSFLIRSYEIGADRTASIETLMNHLQETSINHCKSLGLLNDGFGRTPGMCKNDLIWVLTKMQIMVNRYPAWGDTVEINTWFSQSGKIGMGSDWLISDCNTGEILIRATSVWAMMNQKTRRFSRLPYEVRQELTPHFVDSPHVIEDNDRKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVSNVKYIGWILESMPIEVLEAQELCSLTVEYRRECGMDSVLESVTAVDPSEDGGRSQYNHLLRLEDGTDVVKGRTEWRPKNAETNGAISPGNTSNGNSIS
서열 번호 173
CprocFATB2 (쿠페아 프로컴벤스 FATB2)
MVAAAASSAFFPAPAPGSSPKPGKSGNWPSSLSPSFKSKSIPYGRFQVKANASAHPKANGSAVNLKSGSLNTQEDTSSSPPPRAFLNQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLVDSVGLKNIVRDGLVSRQSFLIRSYEIGADRTASIETLMNHLQETSINHCKSLGLLNDGFGRTPGMCKNDLIWVLTKMQIMVNRYPAWGDTVEINTWFSQSGKIGMGSDWLISDCNTGEILIRATSVWAMMNQKTRRFSRLPYEVRQELTPHFVDSPHVIEDNDRKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRQECGRESVLESLTAVDPSGKGFGSQFQHLLRLEDGGEIVKGRTEWRPKTAGINGAIASGETSPGDF
서열 번호 174
CprocFATB3 (쿠페아 프로컴벤스 FATB3)
MVAAAASSAFFPAPAPGSSPKPGKSGNWPSSLSPSFKSKSIPYGRFQVKANASAHPKANGSAVNLKSGSLNTQEDTSSSPPPRAFLNQLPDWSMLLSAITTVFVAAEKQWTMLDRKSKRPDMLVDSVGLKNIVRDGLVSRQSFLIRSYEIGADRTASIETLMNHLQETSINHCKSLGLLNDGFGRTPGMCKNDLIWVLTKMQIMVNRYPAWGDTVEINTWFSQSGKIGMGSDWLISDCNTGEILIRATSVWAMMNQKTRRFSRLPYEVRQELTPHFVDSPHVIEDNDRKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGRESVLESLTAVDPSGEGGYGSQFQHLLRLEDGGEIVKGRTEWRPKNAGINGVLPTGE
서열 번호 175
CigneaFATB1 (쿠페아 이그네아 FATB1)
PGTSRKTGKFGNWPSSLSPSFKPKSIPNGGFQVKANARAHPKANGSAVSLKSVSLNTQEDTSLSPPPRAFLNQLPDWRMLRTALTTVFVAAEKQWTMLDRKSKRPDMLVDSFGLESIVQEGLVFRQSFSIRSYEIGIDRTASIETLMNHLQETSLNQCKSAGILHDGFGRTLEMCKRDLIWVVTKMQIKVNRYPAWGDTVEISTRFSRLGKIGMGRDWLICDCNTGEILIRATSAYAMMNQKTRRLSKLPNEVRQEIAPLFVDSDPVIEENDMKLHKFEVKTGDSICKGLTPRWSDLDVNQHVSNVKYIGWILESMPTEVLETQELCSLALEYRRECGRDSVLESVTSMDPSKVGGWSQYQHLLRLEDGADIVKGRTEWRPKNAGANGAISTGKT
서열 번호 176
CcalcFATB1 (쿠페아 칼카라타 FATB1)
Figure pct00025
서열 번호 177
ChookFATB4 (쿠페아 후케리아나 FATB4)
Figure pct00026
서열 번호 178
CaFATB1 (쿠페아 아비게라 변이형 풀체리마 FATB1)
Figure pct00027
서열 번호 179
CpauFATB1 (쿠페아 파우시페타라 FATB1)
Figure pct00028
서열 번호 180
CprocFATB1 (쿠페아 프로컴벤스 FATB1)
Figure pct00029
서열 번호 181
CprocFATB2 (쿠페아 프로컴벤스 FATB2)
Figure pct00030
서열 번호 182
CprocFATB3 (쿠페아 프로컴벤스 FATB3)
Figure pct00031
서열 번호 183
CigneaFATB1 (쿠페아 이그네아 FATB1)
Figure pct00032
서열 번호 184
CgFATB1 (쿠페아 글로쏘스토마 FATB1)_
Figure pct00033
서열 번호 185
CgFATB1b (쿠페아 글로쏘스토마 FATB1 C170F,M198T,T374S 변이형)
MVAAAASSAFFPSPAPGSSPKPGNRPSSLSPSFKPKSIPNGAFQVKANASAHPKANGSAVNLKSGSLNTQEDSSSSPSPRAFLNQLPDWSVLLTAITTVFVAAEKQWTMLDRKSKRPDVLVDSVGLKSIVQDGLVSRQSFSIRSYEIGADRTASIETLMNHLQETSINHFKSLGLLNDGFGRTPGMCKNDLIWVLTKTQIMVNRYPAWGDTVEINTWFSQSGKIGMGSDWLISDCNTGEILIRATSVWAMMNQKTRRFSRLPYEVRQELTPHFVDSPHVIEDNDRKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVSNVKYIGWILESMPIEVLETQELCSLTVEYRRECGMDSVLESVSAMDPSEDGGRSQYNHLLRLEDGTDVVKGRTEWRPKNAGTNGAISTTKTSNGNSVS
서열 번호 186
엄벨루라리아 캘리포르니카(Umbellularia californica) UcFATB3 아미노산 서열
MVATAAASAFFPVGSPATSSATSAKASMMPDNLDARGIKPKPASSSGLQVKANAHASPKINGSKVSTDTLKGEDTLTSSPAPRTFINQLPDWSMFLAAITTIFLAAEKQWTNLDWKPRRPDMLADPFGIGRFMQDGLIFRQHFAIRSYEIGADRTASIETLMNHLQETALNHVRSAGLLGDGFGATPEMSRRDLIWVVTRMQVLVDRYPAWGDIVEVETWVGASGKNGMRRDWLVRDSQTGEILTRATSVWVMMNKRTRRLSKIPEEVRGEIGPYFMENVAIIEEDSRKLQKLNENIIEEDSRKLQKLNENTADNVRRGLTPRWSDLDVNQHVNNVKYIGWILESAPGSILESHELSCMTLEYRRECGKDSVLQSMTVVSGGGSAAGGSPESSVECDHLLQLESGPEVVKARTEWRPKSANNPRSILEMPAESS*
서열 번호 187
쿠페아 카르타게네시스 CCrFATB2c (FATB2의 V138L 변이형)
MVAAAASSAFFPVTTPGTSRKPGKFGNWLSSLSPPFRPKSIPSGGFQVKANASAHPKANGSAVSLKSGSLNTQEDTSSSPPPRAFINQLPDWSMLLTAITTVFVAAEKQWTMLDRKSKRSDMLVDSFGMERIVQDGLLFRQSFSIRSYEIGADRRASIETLMNHLQETSLNHCKSIRLLNEGFGRTPEMCKRDLIWVVTRMHIMVNRYPTWGDTVEINTWVSQSGKNGMGRDWLISDCNTGEILIRATSAWAMMNQKTRRLSKLPYEVSQEIAPHFVDSPPVIEDGDRKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVNNVKYIGWILESMPTEVLETHELCFLTLEYRRECGRDSVLESVTAMDPSNEGGRSHYQHLLRLEDGTDIVKGRTEWRPKNARNIGAISTGKTSNGNPAS*
서열 번호 188
쿠페아 카르타게네시스 CCrFATB2
MVAAAASSAFFPVTTPGTSRKPGKFGNWLSSLSPPFRPKSIPSGGFQVKANASAHPKANGSAVSLKSGSLNTQEDTSSSPPPRAFINQLPDWSMLLTAITTVFVAAEKQWTMLDRKSKRSDMLVDSFGMERIVQDGLVFRQSFSIRSYEIGADRRASIETLMNHLQETSLNHCKSIRLLNEGFGRTPEMCKRDLIWVVTRMHIMVNRYPTWGDTVEINTWVSQSGKNGMGRDWLISDCNTGEILIRATSAWAMMNQKTRRLSKLPYEVSQEIAPHFVDSPPVIEDGDRKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVNNVKYIGWILESMPTEVLETHELCFLTLEYRRECGRDSVLESVTAMDPSNEGGRSHYQHLLRLEDGTDIVKGRTEWRPKNARNIGAISTGKTSNGNPAS*
서열 번호 189
CcrFATB2b
MVAAAASSAFFPVTTPGTSRKPGKFGNWLSSLSPPFRPKSIPSGGFQVKANASAHPKANGSAVSLKSGSLNTQEDTSSSPPPRAFINQLPDWSMLLTAITTVFVAAEKQWTMLDRKSKRSDMLVDSFGMERIVQDGLVFRQSFSIRSYEIGADRRASIETLMNHLQETSLNHCKSIRLLNEGFGRTPEMCKRDLIWVFTRMHIMVNRYPTWGDTVEINTWVSQSGKNGMGRDWLISDCNTGEILIRATSAWAMMNQKTRRLSKLPYEVSQEIAPHFVDSPPVIEDGDRKLHKFDVKTGDSIRKGLTPRWNDLDVNQHVNNVKYIGWILESMPTEVLETHELCFLTLEYRRECGRDSVLESVTAMDPSNEGGRSHYQHLLRLEDGTDIVKGRTEWRPKNARNIGAIPTGKTSNGNPAS*
서열 번호 190
CcrFATB1
MVATAASSAFFPVPSPDSSSRPGKLGNGPSSLSPLKPKSTPNGGLQVKANASAPPKINGSSVGLKSSSLKTQDDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLTDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNDGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRHEIEPHFVDSAPVIEDDDRKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGKESVLESLTAVDPSGKGWGSHFQHLLRLEDGGEIVKGRTEWRPKNAGINGAVAFEETSPGDS*
서열 번호 191
CcrFATB1b
MVATAASSAFFPVPSPDSSSRPGKLGNGPSSLSPLKPKSTPNGGLQVKANASAPPKINGSSVGLKSSSLKTQDDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLTDPFGLGRIAQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNDGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRHEIEPHFVDSAPVIEDDDRKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGKESVLESLTAVDPSGKGWGSHFQHLLRLEDGGEIVKGRTEWRPKNAGINGAVAFEETSPGDS*
서열 번호 192
CCrFATB1c
MVATAASSAFFPVPSPDSSSRPGKLGNGPSSLSPLKPKSTPNGGLQVKANASAPPKINGSSVGLKSSSLKTQDDTPSAPPPRTFINQLPDWSMLLAAITTVFLAAEKQWMMLDWKPKRPDMLTDPFGLGRIVQDGLVFRQNFSIRSYEIGADRTASIETVMNHLQETALNHVKSAGLLNDGFGRTPEMYKRDLIWVVAKMQVMVNRYPTWGDTVEVNTWVAKSGKNGMRRDWLISDCNTGEILTRASSVWVMMNQKTRRLSKIPDEVRHEIEPHFVDSAPVIEDDDRKLPKLDEKTADSIRKGLTPKWNDLDVNQHVNNVKYIGWILESTPPEVLETQELCSLTLEYRRECGKESVLESLTAVDPSGKGWGSHFQHLLRLEDGGEIVKGRTEWRPKNA*
SEQUENCE LISTING <110> SOLAZYME, INC. <120> THIOESTERASES AND CELLS FOR PRODUCTION OF TAILORED OILS <130> SOLAP019WO <140> PCT/US2014/026644 <141> 2014-03-13 <150> 61/917,217 <151> 2013-12-17 <150> 13/837,996 <151> 2013-03-15 <150> 61/791,861 <151> 2013-03-15 <160> 194 <170> PatentIn version 3.5 <210> 1 <211> 380 <212> PRT <213> Cinnamomum camphora <400> 1 Met Ala Thr Thr Ser Leu Ala Ser Ala Phe Cys Ser Met Lys Ala Val 1 5 10 15 Met Leu Ala Arg Asp Gly Arg Gly Leu Lys Pro Arg Ser Ser Asp Leu 20 25 30 Gln Leu Arg Ala Gly Asn Ala Gln Thr Ser Leu Lys Met Ile Asn Gly 35 40 45 Thr Lys Phe Ser Tyr Thr Glu Ser Leu Lys Lys Leu Pro Asp Trp Ser 50 55 60 Met Leu Phe Ala Val Ile Thr Thr Ile Phe Ser Ala Ala Glu Lys Gln 65 70 75 80 Trp Thr Asn Leu Glu Trp Lys Pro Lys Pro Asn Pro Pro Gln Leu Leu 85 90 95 Asp Asp His Phe Gly Pro His Gly Leu Val Phe Arg Arg Thr Phe Ala 100 105 110 Ile Arg Ser Tyr Glu Val Gly Pro Asp Arg Ser Thr Ser Ile Val Ala 115 120 125 Val Met Asn His Leu Gln Glu Ala Ala Leu Asn His Ala Lys Ser Val 130 135 140 Gly Ile Leu Gly Asp Gly Phe Gly Thr Thr Leu Glu Met Ser Lys Arg 145 150 155 160 Asp Leu Ile Trp Val Val Lys Arg Thr His Val Ala Val Glu Arg Tyr 165 170 175 Pro Ala Trp Gly Asp Thr Val Glu Val Glu Cys Trp Val Gly Ala Ser 180 185 190 Gly Asn Asn Gly Arg Arg His Asp Phe Leu Val Arg Asp Cys Lys Thr 195 200 205 Gly Glu Ile Leu Thr Arg Cys Thr Ser Leu Ser Val Met Met Asn Thr 210 215 220 Arg Thr Arg Arg Leu Ser Lys Ile Pro Glu Glu Val Arg Gly Glu Ile 225 230 235 240 Gly Pro Ala Phe Ile Asp Asn Val Ala Val Lys Asp Glu Glu Ile Lys 245 250 255 Lys Pro Gln Lys Leu Asn Asp Ser Thr Ala Asp Tyr Ile Gln Gly Gly 260 265 270 Leu Thr Pro Arg Trp Asn Asp Leu Asp Ile Asn Gln His Val Asn Asn 275 280 285 Ile Lys Tyr Val Asp Trp Ile Leu Glu Thr Val Pro Asp Ser Ile Phe 290 295 300 Glu Ser His His Ile Ser Ser Phe Thr Ile Glu Tyr Arg Arg Glu Cys 305 310 315 320 Thr Arg Asp Ser Val Leu Gln Ser Leu Thr Thr Val Ser Gly Gly Ser 325 330 335 Ser Glu Ala Gly Leu Val Cys Glu His Leu Leu Gln Leu Glu Gly Gly 340 345 350 Ser Glu Val Leu Arg Ala Lys Thr Glu Trp Arg Pro Lys Leu Ser Phe 355 360 365 Arg Gly Ile Ser Val Ile Pro Ala Glu Ser Ser Val 370 375 380 <210> 2 <211> 1128 <212> DNA <213> Cinnamomum camphora <400> 2 ttagcttctg ctttctgctc gatgaaagct gtaatgttgg ctcgtgatgg caggggcttg 60 aaacccagga gcagtgattt gcagctgagg gcgggaaatg cacaaacctc tttgaagatg 120 atcaatggga ccaagttcag ttacacagag agcttgaaaa agttgcctga ctggagcatg 180 ctctttgcag tgatcacgac catcttttcg gctgctgaga agcagtggac caatctagag 240 tggaagccga agccgaatcc accccagttg cttgatgacc attttgggcc gcatgggtta 300 gttttcaggc gcacctttgc catcagatcg tatgaggtgg gacctgaccg ctccacatct 360 atagtggctg ttatgaatca cttgcaggag gctgcactta atcatgcgaa gagtgtggga 420 attctaggag atggattcgg tacgacgcta gagatgagta agagagatct gatatgggtt 480 gtgaaacgca cgcatgttgc tgtggaacgg taccctgctt ggggtgatac tgttgaagta 540 gagtgctggg ttggtgcatc gggaaataat ggcaggcgcc atgatttcct tgtccgggac 600 tgcaaaacag gcgaaattct tacaagatgt accagtcttt cggtgatgat gaatacaagg 660 acaaggaggt tgtccaaaat ccctgaagaa gttagagggg agatagggcc tgcattcatt 720 gataatgtgg ctgtcaagga cgaggaaatt aagaaaccac agaagctcaa tgacagcact 780 gcagattaca tccaaggagg attgactcct cgatggaatg atttggatat caatcagcac 840 gttaacaaca tcaaatacgt tgactggatt cttgagactg tcccagactc aatctttgag 900 agtcatcata tttccagctt cactattgaa tacaggagag agtgcacgag ggatagcgtg 960 ctgcagtccc tgaccactgt ctccggtggc tcgtcggaag ctgggttagt gtgcgagcac 1020 ttgctccagc ttgaaggtgg gtctgaggta ttgagggcaa aaacagagtg gaggcctaag 1080 cttagtttca gagggattag tgtgataccc gcagaatcga gtgtctaa 1128 <210> 3 <211> 1128 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 3 ttagcttctg ctttctgctc gatgaaagct gtaatgttgg ctcgtgatgg caggggcttg 60 aaacccagga gcagtgattt gcagctgagg gcgggaaatg cacaaacctc tttgaagatg 120 atcaatggga ccaagttcag ttacacagag agcttgaaaa agttgcctga ctggagcatg 180 ctctttgcag tgatcacgac catcttttcg gctgctgaga agcagtggac caatctagag 240 tggaagccga agccgaatcc accccagttg cttgatgacc attttgggcc gcatgggtta 300 gttttcaggc gcacctttgc catcagatcg tatgaggtgg gacctgaccg ctccacatct 360 atagtggctg ttatgaatca cttgcaggag gctgcactta atcatgcgaa gagtgtggga 420 attctaggag atggattcgg tacgacgcta gagatgagta agagagatct gatatgggtt 480 gtgaaacgca cgcatgttgc tgtggaacgg taccctgctt ggggtgatac tgttgaagta 540 gagtgctggg ttggtgcatc gggaaataat ggcaggcgcc atgatttcct tgtccgggac 600 tgcaaaacag gcgaaattct tacaagatgt accagtcttt cggtgatgat gaatacaagg 660 acaaggaggt tgtccaaaat ccctgaagaa gttagagggg agatagggcc tgcattcatt 720 gataatgtgg ctgtcaagga cgaggaaatt aagaaaccac agaagctcaa tgacagcact 780 gcagattaca tccaaggagg attgactcct cgatggaatg atttggatat caatcagcac 840 gttaacaaca tcaaatacgt tgactggatt cttgagactg tcccagactc aatctttgag 900 agtcatcata tttccagctt cactattgaa tacaggagag agtgcacgag ggatagcgtg 960 ctgcagtccc tgaccactgt ctccggtggc tcgtcggaag ctgggttagt gtgcgagcac 1020 ttgctccagc ttgaaggtgg gtctgaggta ttgagggcaa aaacagagtg gaggcctaag 1080 cttagtttca gagggattag tgtgataccc gcagaatcga gtgtctaa 1128 <210> 4 <211> 357 <212> PRT <213> Cinnamomum camphora <400> 4 Met Val Thr Thr Ser Leu Ala Ser Ala Tyr Phe Ser Met Lys Ala Val 1 5 10 15 Met Leu Ala Pro Asp Gly Arg Gly Ile Lys Pro Arg Ser Ser Gly Leu 20 25 30 Gln Val Arg Ala Gly Asn Glu Arg Asn Ser Cys Lys Val Ile Asn Gly 35 40 45 Thr Lys Val Lys Asp Thr Glu Gly Leu Lys Gly Cys Ser Thr Leu Gln 50 55 60 Gly Gln Ser Met Leu Asp Asp His Phe Gly Leu His Gly Leu Val Phe 65 70 75 80 Arg Arg Thr Phe Ala Ile Arg Cys Tyr Glu Val Gly Pro Asp Arg Ser 85 90 95 Thr Ser Ile Met Ala Val Met Asn His Leu Gln Glu Ala Ala Arg Asn 100 105 110 His Ala Glu Ser Leu Gly Leu Leu Gly Asp Gly Phe Gly Glu Thr Leu 115 120 125 Glu Met Ser Lys Arg Asp Leu Ile Trp Val Val Arg Arg Thr His Val 130 135 140 Ala Val Glu Arg Tyr Pro Ala Trp Gly Asp Thr Val Glu Val Glu Ala 145 150 155 160 Trp Val Gly Ala Ser Gly Asn Thr Gly Met Arg Arg Asp Phe Leu Val 165 170 175 Arg Asp Cys Lys Thr Gly His Ile Leu Thr Arg Cys Thr Ser Val Ser 180 185 190 Val Met Met Asn Met Arg Thr Arg Arg Leu Ser Lys Ile Pro Gln Glu 195 200 205 Val Arg Ala Glu Ile Asp Pro Leu Phe Ile Glu Lys Val Ala Val Lys 210 215 220 Glu Gly Glu Ile Lys Lys Leu Gln Lys Leu Asn Asp Ser Thr Ala Asp 225 230 235 240 Tyr Ile Gln Gly Gly Trp Thr Pro Arg Trp Asn Asp Leu Asp Val Asn 245 250 255 Gln His Val Asn Asn Ile Ile Tyr Val Gly Trp Ile Phe Lys Ser Val 260 265 270 Pro Asp Ser Ile Ser Glu Asn His His Leu Ser Ser Ile Thr Leu Glu 275 280 285 Tyr Arg Arg Glu Cys Thr Arg Gly Asn Lys Leu Gln Ser Leu Thr Thr 290 295 300 Val Cys Gly Gly Ser Ser Glu Ala Gly Ile Ile Cys Glu His Leu Leu 305 310 315 320 Gln Leu Glu Asp Gly Ser Glu Val Leu Arg Ala Arg Thr Glu Trp Arg 325 330 335 Pro Lys His Thr Asp Ser Phe Gln Gly Ile Ser Glu Arg Phe Pro Gln 340 345 350 Gln Glu Pro His Lys 355 <210> 5 <211> 1074 <212> DNA <213> Cinnamomum camphora <400> 5 atggtcacca cctctttagc ttccgcttac ttctcgatga aagctgtaat gttggctcct 60 gacggcaggg gcataaagcc caggagcagt ggtttgcagg tgagggcggg aaatgaacga 120 aactcttgca aggtgatcaa tgggaccaag gtcaaagaca cggagggctt gaaagggtgc 180 agcacgttgc aaggccagag catgcttgat gaccattttg gtctgcatgg gctagttttc 240 aggcgcacct ttgcaatcag atgctatgag gttggacctg accgctccac atccataatg 300 gctgttatga atcacttgca ggaagctgca cgtaatcatg cggagagtct gggacttcta 360 ggagatggat tcggtgagac actggagatg agtaagagag atctgatatg ggttgtgaga 420 cgcacgcatg ttgctgtgga acggtaccct gcttggggcg atactgttga agtcgaggcc 480 tgggtgggtg catcaggtaa cactggcatg cgccgcgatt tccttgtccg cgactgcaaa 540 actggccaca ttcttacaag atgtaccagt gtttcagtga tgatgaatat gaggacaagg 600 agattgtcca aaattcccca agaagttaga gcggagattg accctctttt cattgaaaag 660 gttgctgtca aggaagggga aattaaaaaa ttacagaagt tgaatgatag cactgcagat 720 tacattcaag ggggttggac tcctcgatgg aatgatttgg atgtcaatca gcacgtgaac 780 aatatcatat acgttggctg gatttttaag agcgtcccag actctatctc tgagaatcat 840 catctttcta gcatcactct cgaatacagg agagagtgca caaggggcaa caagctgcag 900 tccctgacca ctgtttgtgg tggctcgtcg gaagctggga tcatatgtga gcacctactc 960 cagcttgagg atgggtctga ggttttgagg gcaagaacag agtggaggcc caagcacacc 1020 gatagtttcc aaggcattag tgagagattc ccgcagcaag aaccgcataa gtaa 1074 <210> 6 <211> 1074 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 6 atggtgacca cctccctggc ctccgcctac ttctccatga aggccgtgat gctggccccc 60 gacggccgcg gcatcaagcc ccgctcctcc ggcctgcagg tgcgcgccgg caacgagcgc 120 aactcctgca aggtgatcaa cggcaccaag gtgaaggaca ccgagggcct gaagggctgc 180 tccaccctgc agggccagtc catgctggac gaccacttcg gcctgcacgg cctggtgttc 240 cgccgcacct tcgccatccg ctgctacgag gtgggccccg accgctccac ctccatcatg 300 gccgtgatga accacctgca ggaggccgcc cgcaaccacg ccgagtccct gggcctgctg 360 ggcgacggct tcggcgagac cctggagatg tccaagcgcg acctgatctg ggtggtgcgc 420 cgcacccacg tggccgtgga gcgctacccc gcctggggcg acaccgtgga ggtggaggcc 480 tgggtgggcg cctccggcaa caccggcatg cgccgcgact tcctggtgcg cgactgcaag 540 accggccaca tcctgacccg ctgcacctcc gtgtccgtga tgatgaacat gcgcacccgc 600 cgcctgtcca agatccccca ggaggtgcgc gccgagatcg accccctgtt catcgagaag 660 gtggccgtga aggagggcga gatcaagaag ctgcagaagc tgaacgactc caccgccgac 720 tacatccagg gcggctggac cccccgctgg aacgacctgg acgtgaacca gcacgtgaac 780 aacatcatct acgtgggctg gatcttcaag tccgtgcccg actccatctc cgagaaccac 840 cacctgtcct ccatcaccct ggagtaccgc cgcgagtgca cccgcggcaa caagctgcag 900 tccctgacca ccgtgtgcgg cggctcctcc gaggccggca tcatctgcga gcacctgctg 960 cagctggagg acggctccga ggtgctgcgc gcccgcaccg agtggcgccc caagcacacc 1020 gactccttcc agggcatctc cgagcgcttc ccccagcagg agccccacaa gtga 1074 <210> 7 <211> 419 <212> PRT <213> Cinnamomum camphora <400> 7 Met Val Ala Thr Ala Ala Ala Ser Ala Phe Phe Pro Val Gly Ala Pro 1 5 10 15 Ala Thr Ser Ser Ala Thr Ser Ala Lys Ala Ser Met Met Pro Asp Asn 20 25 30 Leu Asp Ala Arg Gly Ile Lys Pro Lys Pro Ala Ser Ser Ser Gly Leu 35 40 45 Gln Val Lys Ala Asn Ala His Ala Ser Pro Lys Ile Asn Gly Ser Lys 50 55 60 Val Ser Thr Asp Thr Leu Lys Gly Glu Asp Thr Leu Thr Ser Ser Pro 65 70 75 80 Ala Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Phe Leu 85 90 95 Ala Ala Ile Thr Thr Ile Phe Leu Ala Ala Glu Lys Gln Trp Thr Asn 100 105 110 Leu Asp Trp Lys Pro Arg Arg Pro Asp Met Leu Ala Asp Pro Phe Gly 115 120 125 Ile Gly Arg Phe Met Gln Asp Gly Leu Ile Phe Arg Gln His Phe Ala 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Arg Ser Ala 165 170 175 Gly Leu Leu Gly Asp Gly Phe Gly Ala Thr Pro Glu Met Ser Arg Arg 180 185 190 Asp Leu Ile Trp Val Val Thr Arg Met Gln Val Leu Val Asp Arg Tyr 195 200 205 Pro Ala Trp Gly Asp Ile Val Glu Val Glu Thr Trp Val Gly Ala Ser 210 215 220 Gly Lys Asn Gly Met Arg Arg Asp Trp Leu Val Arg Asp Ser Gln Thr 225 230 235 240 Gly Glu Ile Leu Thr Arg Ala Thr Ser Val Trp Val Met Met Asn Lys 245 250 255 Arg Thr Arg Arg Leu Ser Lys Leu Pro Glu Glu Val Arg Gly Glu Ile 260 265 270 Gly Pro Tyr Phe Ile Glu Asp Val Ala Ile Ile Glu Glu Asp Asn Arg 275 280 285 Lys Leu Gln Lys Leu Asn Glu Asn Thr Ala Asp Asn Val Arg Arg Gly 290 295 300 Leu Thr Pro Arg Trp Ser Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Ala Pro Gly Ser Ile Leu 325 330 335 Glu Ser His Glu Leu Ser Cys Met Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Lys Asp Ser Val Leu Gln Ser Met Thr Ala Val Ser Gly Gly Gly 355 360 365 Ser Ala Ala Gly Gly Ser Pro Glu Ser Ser Val Glu Cys Asp His Leu 370 375 380 Leu Gln Leu Glu Ser Gly Pro Glu Val Val Arg Gly Arg Thr Glu Trp 385 390 395 400 Arg Pro Lys Ser Ala Asn Asn Ser Arg Ser Ile Leu Glu Met Pro Ala 405 410 415 Glu Ser Leu <210> 8 <211> 1254 <212> DNA <213> Cinnamomum camphora <400> 8 atggttgcca ccgctgctgc ttctgctttc ttcccggtcg gtgctccggc tacgtcatct 60 gcaacttcag ccaaagcgtc gatgatgcct gataatttgg atgccagagg catcaaaccg 120 aagccggctt cgtccagcgg cttgcaggtt aaggcaaatg cccatgcctc tcccaagatt 180 aatggttcca aggtgagcac ggataccttg aagggggaag acaccttaac ttcctcgccc 240 gccccacgga cctttatcaa ccaattgcct gactggagca tgttccttgc tgccatcaca 300 actattttct tggctgccga gaagcagtgg acgaatctcg actggaagcc cagaagaccc 360 gacatgcttg ctgacccgtt tggcatcggg aggtttatgc aggatgggct gattttcagg 420 cagcactttg caatcagatc ttatgagatt ggggctgata gaacggcgtc tatagagact 480 ttaatgaatc acttgcagga gactgcactt aatcatgtga ggagtgctgg actcctaggt 540 gatggatttg gtgcgacacc tgagatgagt agaagagatc tgatatgggt tgtaacacgt 600 atgcaggttc ttgtggaccg ctaccctgct tggggtgata ttgttgaagt agagacctgg 660 gttggtgcat ctggaaaaaa tggtatgcgc cgtgattggc ttgttcggga cagccaaact 720 ggtgaaattc tcacacgagc taccagtgtt tgggtgatga tgaataaacg gacaaggcga 780 ttgtccaaac ttcctgaaga agttagaggg gaaatagggc cttattttat agaagatgtt 840 gctatcatag aggaggacaa caggaaacta cagaagctca atgaaaacac tgctgataat 900 gttcgaaggg gtttgactcc tcgctggagt gatctggatg ttaatcagca tgtgaacaat 960 gtcaaataca ttggttggat tcttgagagt gcaccaggat ccatcttgga gagtcatgag 1020 ctttcctgca tgacccttga atacaggaga gaatgtggga aggacagtgt gctgcagtca 1080 atgactgctg tctctggtgg aggcagtgca gcaggtggct caccagaatc tagcgttgag 1140 tgtgaccact tgctccagct agagagtggg cctgaagttg tgaggggaag aaccgagtgg 1200 aggcccaaga gtgctaataa ctcgaggagc atcctggaga tgccggccga gagc 1254 <210> 9 <211> 1260 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 9 atggtggcca ccgccgccgc ctccgccttc ttccccgtgg gcgcccccgc cacctcctcc 60 gccacctccg ccaaggcctc catgatgccc gacaacctgg acgcccgcgg catcaagccc 120 aagcccgcct cctcctccgg cctgcaggtg aaggccaacg cccacgcctc ccccaagatc 180 aacggctcca aggtgtccac cgacaccctg aagggcgagg acaccctgac ctcctccccc 240 gccccccgca ccttcatcaa ccagctgccc gactggtcca tgttcctggc cgccatcacc 300 accatcttcc tggccgccga gaagcagtgg accaacctgg actggaagcc ccgccgcccc 360 gacatgctgg ccgacccctt cggcatcggc cgcttcatgc aggacggcct gatcttccgc 420 cagcacttcg ccatccgctc ctacgagatc ggcgccgacc gcaccgcctc catcgagacc 480 ctgatgaacc acctgcagga gaccgccctg aaccacgtgc gctccgccgg cctgctgggc 540 gacggcttcg gcgccacccc cgagatgtcc cgccgcgacc tgatctgggt ggtgacccgc 600 atgcaggtgc tggtggaccg ctaccccgcc tggggcgaca tcgtggaggt ggagacctgg 660 gtgggcgcct ccggcaagaa cggcatgcgc cgcgactggc tggtgcgcga ctcccagacc 720 ggcgagatcc tgacccgcgc cacctccgtg tgggtgatga tgaacaagcg cacccgccgc 780 ctgtccaagc tgcccgagga ggtgcgcggc gagatcggcc cctacttcat cgaggacgtg 840 gccatcatcg aggaggacaa ccgcaagctg cagaagctga acgagaacac cgccgacaac 900 gtgcgccgcg gcctgacccc ccgctggtcc gacctggacg tgaaccagca cgtgaacaac 960 gtgaagtaca tcggctggat cctggagtcc gcccccggct ccatcctgga gtcccacgag 1020 ctgtcctgca tgaccctgga gtaccgccgc gagtgcggca aggactccgt gctgcagtcc 1080 atgaccgccg tgtccggcgg cggctccgcc gccggcggct cccccgagtc ctccgtggag 1140 tgcgaccacc tgctgcagct ggagtccggc cccgaggtgg tgcgcggccg caccgagtgg 1200 cgccccaagt ccgccaacaa ctcccgctcc atcctggaga tgcccgccga gtccctgtga 1260 <210> 10 <211> 361 <212> PRT <213> Cuphea hyssopifolia <400> 10 Met Val Ala Thr Asn Ala Ala Ala Phe Ser Ala Tyr Thr Phe Phe Leu 1 5 10 15 Thr Ser Pro Thr His Gly Tyr Ser Ser Lys Arg Leu Ala Asp Thr Gln 20 25 30 Asn Gly Tyr Pro Gly Thr Ser Leu Lys Ser Lys Ser Thr Pro Pro Pro 35 40 45 Ala Ala Ala Ala Ala Arg Asn Gly Ala Leu Pro Leu Leu Ala Ser Ile 50 55 60 Cys Lys Cys Pro Lys Lys Ala Asp Gly Ser Met Gln Leu Asp Ser Ser 65 70 75 80 Leu Val Phe Gly Phe Gln Phe Tyr Ile Arg Ser Tyr Glu Val Gly Ala 85 90 95 Asp Gln Thr Val Ser Ile Gln Thr Val Leu Asn Tyr Leu Gln Glu Ala 100 105 110 Ala Ile Asn His Val Gln Ser Ala Gly Tyr Phe Gly Asp Ser Phe Gly 115 120 125 Ala Thr Pro Glu Met Thr Lys Arg Asn Leu Ile Trp Val Ile Thr Lys 130 135 140 Met Gln Val Leu Val Asp Arg Tyr Pro Ala Trp Gly Asp Val Val Gln 145 150 155 160 Val Asp Thr Trp Thr Cys Ser Ser Gly Lys Asn Ser Met Gln Arg Asp 165 170 175 Trp Phe Val Arg Asp Leu Lys Thr Gly Asp Ile Ile Thr Arg Ala Ser 180 185 190 Ser Val Trp Val Leu Met Asn Arg Leu Thr Arg Lys Leu Ser Lys Ile 195 200 205 Pro Glu Ala Val Leu Glu Glu Ala Lys Leu Phe Val Met Asn Thr Ala 210 215 220 Pro Thr Val Asp Asp Asn Arg Lys Leu Pro Lys Leu Asp Gly Ser Ser 225 230 235 240 Ala Asp Tyr Val Leu Ser Gly Leu Thr Pro Arg Trp Ser Asp Leu Asp 245 250 255 Met Asn Gln His Val Asn Asn Val Lys Tyr Ile Ala Trp Ile Leu Glu 260 265 270 Ser Val Pro Gln Ser Ile Pro Glu Thr His Lys Leu Ser Ala Ile Thr 275 280 285 Val Glu Tyr Arg Arg Glu Cys Gly Lys Asn Ser Val Leu Gln Ser Leu 290 295 300 Thr Asn Val Ser Gly Asp Gly Ile Thr Cys Gly Asn Ser Ile Ile Glu 305 310 315 320 Cys His His Leu Leu Gln Leu Glu Thr Gly Pro Glu Ile Leu Leu Ala 325 330 335 Arg Thr Glu Trp Ile Ser Lys Glu Pro Gly Phe Arg Gly Ala Pro Ile 340 345 350 Gln Ala Glu Lys Val Tyr Asn Asn Lys 355 360 <210> 11 <211> 1086 <212> DNA <213> Cuphea hyssopifolia <400> 11 atggttgcca ctaatgctgc tgccttttct gcttatactt tcttccttac ttcaccaact 60 catggttact cttccaaacg tctcgccgat actcaaaatg gttatccggg tacctccttg 120 aaatcgaaat ccactcctcc accagctgct gctgctgctc gtaacggtgc attgccactg 180 ctggcctcca tctgcaaatg ccccaaaaag gctgatggga gtatgcaact agacagctcc 240 ttggtcttcg ggtttcaatt ttacattaga tcatatgaag tgggtgcgga tcaaaccgtg 300 tcaatacaga cagtactcaa ttacttacag gaggcagcca tcaatcatgt tcagagtgct 360 ggctattttg gtgatagttt tggcgccacc ccggaaatga ccaagaggaa cctcatctgg 420 gttatcacta agatgcaggt tttggtggat cgctatcccg cttggggcga tgttgttcaa 480 gttgatacat ggacctgtag ttctggtaaa aacagcatgc agcgtgattg gttcgtacgg 540 gatctcaaaa ctggagatat tataacaaga gcctcgagcg tgtgggtgct gatgaataga 600 ctcaccagaa aattatcaaa aattcctgaa gcagttctgg aagaagcaaa actttttgtg 660 atgaacactg cccccaccgt agatgacaac aggaagctac caaagctgga tggcagcagt 720 gctgattatg tcctctctgg cttaactcct agatggagcg acttagatat gaaccagcat 780 gtcaacaatg tgaagtacat agcctggatc cttgagagtg tccctcagag cataccggag 840 acacacaagc tgtcagcgat aaccgtggag tacaggagag aatgtggcaa gaacagcgtc 900 ctccagtctc tgaccaacgt ctccggggat ggaatcacat gtggaaacag tattatcgag 960 tgccaccatt tgcttcaact tgagactggc ccagagattc tactagcgcg gacggagtgg 1020 atatccaagg aacctgggtt caggggagct ccaatccagg cagagaaagt ctacaacaac 1080 aaataa 1086 <210> 12 <211> 1086 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 12 atggtggcca ccaacgccgc cgccttctcc gcctacacct tcttcctgac ctcccccacc 60 cacggctact cctccaagcg cctggccgac acccagaacg gctaccccgg cacctccctg 120 aagtccaagt ccaccccccc ccccgccgcc gccgccgccc gcaacggcgc cctgcccctg 180 ctggcctcca tctgcaagtg ccccaagaag gccgacggct ccatgcagct ggactcctcc 240 ctggtgttcg gcttccagtt ctacatccgc tcctacgagg tgggcgccga ccagaccgtg 300 tccatccaga ccgtgctgaa ctacctgcag gaggccgcca tcaaccacgt gcagtccgcc 360 ggctacttcg gcgactcctt cggcgccacc cccgagatga ccaagcgcaa cctgatctgg 420 gtgatcacca agatgcaggt gctggtggac cgctaccccg cctggggcga cgtggtgcag 480 gtggacacct ggacctgctc ctccggcaag aactccatgc agcgcgactg gttcgtgcgc 540 gacctgaaga ccggcgacat catcacccgc gcctcctccg tgtgggtgct gatgaaccgc 600 ctgacccgca agctgtccaa gatccccgag gccgtgctgg aggaggccaa gctgttcgtg 660 atgaacaccg cccccaccgt ggacgacaac cgcaagctgc ccaagctgga cggctcctcc 720 gccgactacg tgctgtccgg cctgaccccc cgctggtccg acctggacat gaaccagcac 780 gtgaacaacg tgaagtacat cgcctggatc ctggagtccg tgccccagtc catccccgag 840 acccacaagc tgtccgccat caccgtggag taccgccgcg agtgcggcaa gaactccgtg 900 ctgcagtccc tgaccaacgt gtccggcgac ggcatcacct gcggcaactc catcatcgag 960 tgccaccacc tgctgcagct ggagaccggc cccgagatcc tgctggcccg caccgagtgg 1020 atctccaagg agcccggctt ccgcggcgcc cccatccagg ccgagaaggt gtacaacaac 1080 aagtga 1086 <210> 13 <211> 415 <212> PRT <213> Cuphea hyssopifolia <400> 13 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Ala Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Ser Pro Leu Lys Pro Lys Leu Met Ala Asn Gly Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly Leu 50 55 60 Lys Ser Gly Ser Leu Lys Thr Gln Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Asp Gly Phe Gly Arg Thr Leu Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Arg Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys 355 360 365 Gly Ser Gly Ser Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile 385 390 395 400 Asn Gly Pro Ile Ala Ser Gly Glu Thr Ser Pro Gly Asp Ser Ser 405 410 415 <210> 14 <211> 1248 <212> DNA <213> Cuphea hyssopifolia <400> 14 atggtggcta ccgctgcaag ttcagcattc ttccctgtgc cgtcccccga cgcctcctct 60 agacctggaa agctcggcaa tgggtcatcg agcttgagcc ccctcaagcc caaattgatg 120 gccaatggcg ggttgcaggt taaggcaaac gccagtgccc ctcctaagat caatggttct 180 tcggtcggtc taaagtccgg cagtctcaag actcaggaag acactccttc ggcgcctcct 240 ccccggactt ttattaacca gctgcctgat tggagtatgc ttcttgctgc aatcactact 300 gtcttcttgg cagcagagaa gcagtggatg atgcttgatt ggaaacccaa gaggcctgac 360 atgcttgtgg acccgttcgg attgggaagg attgttcaag atgggcttgt gttcaggcag 420 aatttttcga ttaggtccta tgaaataggc gctgatcgca ctgcgtctat agagacggtg 480 atgaaccact tgcaggaaac agctctcaat catgttaaga gtgctgggct tcttaatgac 540 ggctttggtc gtactcttga gatgtataaa agggacctta tttgggttgt tgcaaaaatg 600 caggtcatgg ttaaccgcta tcctacttgg ggcgacacgg ttgaagtgaa tacttgggtt 660 gccaagtcag ggaaaaatgg tatgcgtcgt gattggctca taagtgattg caatacagga 720 gaaattctta ctagagcatc aagtgtgtgg gtcatgatga atcaaaagac aagaagattg 780 tcaaaaattc cagatgaggt tcgacatgag atagagcctc atttcgtgga ctctgctccc 840 gtcattgaag atgatgaccg gaaacttccc aagctggatg agaagactgc tgactccatc 900 cgcaagggtc taactccgaa gtggaatgac ttggatgtca atcagcacgt caacaacgtg 960 aagtacattg ggtggattct tgagagtact ccaccagaag ttctggagac ccaggagtta 1020 tgttccctta ccctggaata taggcgggaa tgcggaaggg agagcgtgct ggagtccctc 1080 actgctgtgg acccctctgg aaagggctct gggtctcagt tccagcacct tctgcggctt 1140 gaggatggag gtgagattgt gaaggggaga actgagtggc gacccaagac tgcaggaatc 1200 aatgggccaa tagcatccgg ggagacctca cctggagact cttcttag 1248 <210> 15 <211> 1248 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 15 atggtggcca ccgccgcctc ctccgccttc ttccccgtgc cctcccccga cgcctcctcc 60 cgccccggca agctgggcaa cggctcctcc tccctgtccc ccctgaagcc caagctgatg 120 gccaacggcg gcctgcaggt gaaggccaac gcctccgccc cccccaagat caacggctcc 180 tccgtgggcc tgaagtccgg ctccctgaag acccaggagg acaccccctc cgcccccccc 240 ccccgcacct tcatcaacca gctgcccgac tggtccatgc tgctggccgc catcaccacc 300 gtgttcctgg ccgccgagaa gcagtggatg atgctggact ggaagcccaa gcgccccgac 360 atgctggtgg accccttcgg cctgggccgc atcgtgcagg acggcctggt gttccgccag 420 aacttctcca tccgctccta cgagatcggc gccgaccgca ccgcctccat cgagaccgtg 480 atgaaccacc tgcaggagac cgccctgaac cacgtgaagt ccgccggcct gctgaacgac 540 ggcttcggcc gcaccctgga gatgtacaag cgcgacctga tctgggtggt ggccaagatg 600 caggtgatgg tgaaccgcta ccccacctgg ggcgacaccg tggaggtgaa cacctgggtg 660 gccaagtccg gcaagaacgg catgcgccgc gactggctga tctccgactg caacaccggc 720 gagatcctga cccgcgcctc ctccgtgtgg gtgatgatga accagaagac ccgccgcctg 780 tccaagatcc ccgacgaggt gcgccacgag atcgagcccc acttcgtgga ctccgccccc 840 gtgatcgagg acgacgaccg caagctgccc aagctggacg agaagaccgc cgactccatc 900 cgcaagggcc tgacccccaa gtggaacgac ctggacgtga accagcacgt gaacaacgtg 960 aagtacatcg gctggatcct ggagtccacc ccccccgagg tgctggagac ccaggagctg 1020 tgctccctga ccctggagta ccgccgcgag tgcggccgcg agtccgtgct ggagtccctg 1080 accgccgtgg acccctccgg caagggctcc ggctcccagt tccagcacct gctgcgcctg 1140 gaggacggcg gcgagatcgt gaagggccgc accgagtggc gccccaagac cgccggcatc 1200 aacggcccca tcgcctccgg cgagacctcc cccggcgact cctcctga 1248 <210> 16 <211> 427 <212> PRT <213> Cuphea hyssopifolia <400> 16 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Ala Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Ser Pro Leu Lys Pro Lys Leu Met Ala Asn Gly Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly Leu 50 55 60 Lys Ser Gly Ser Leu Lys Thr Gln Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Asp Gly Phe Gly Arg Thr Leu Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Lys Ser Gln Ile Met Leu Pro Leu 245 250 255 His Tyr Cys Ser Val Trp Val Met Met Asn Gln Lys Thr Arg Arg Leu 260 265 270 Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu Pro His Phe Val 275 280 285 Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Arg Lys Leu Pro Lys Leu 290 295 300 Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu Thr Pro Lys Trp 305 310 315 320 Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val Lys Tyr Ile Gly 325 330 335 Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu Thr Gln Glu Leu 340 345 350 Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg Glu Ser Val 355 360 365 Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys Gly Ser Gly Ser 370 375 380 Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly Glu Ile Val Lys 385 390 395 400 Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile Asn Gly Pro Ile 405 410 415 Ala Ser Gly Glu Thr Ser Pro Gly Asp Ser Ser 420 425 <210> 17 <211> 1284 <212> DNA <213> Cuphea hyssopifolia <400> 17 atggtggcta ccgctgcaag ttcagcattc ttccctgtgc cgtcccccga cgcctcctct 60 agacctggaa agctcggcaa tgggtcatcg agcttgagcc ccctcaagcc caaattgatg 120 gccaatggcg ggttgcaggt taaggcaaac gccagtgccc ctcctaagat caatggttct 180 tcggtcggtc taaagtccgg cagtctcaag actcaggaag acactccttc ggcgcctcct 240 ccccggactt ttattaacca gctgcctgat tggagtatgc ttcttgctgc aatcactact 300 gtcttcttgg cagcagagaa gcagtggatg atgcttgatt ggaaacccaa gaggcctgac 360 atgcttgtgg acccgttcgg attgggaagg attgttcaag atgggcttgt gttcaggcag 420 aatttttcga ttaggtccta tgaaataggc gctgatcgca ctgcgtctat agagacggtg 480 atgaaccact tgcaggaaac agctctcaat catgttaaga gtgctgggct tcttaatgac 540 ggctttggtc gtactcttga gatgtataaa agggacctta tttgggttgt tgcaaaaatg 600 caggtcatgg ttaaccgcta tcctacttgg ggcgacacgg ttgaagtgaa tacttgggtt 660 gccaagtcag ggaaaaatgg tatgcgtcgt gattggctca taagtgattg caatacagga 720 gaaattctta ctagagcatc aagtaaaagc caaattatgt tacccttaca ttattgcagt 780 gtgtgggtca tgatgaatca aaagacaaga agattgtcaa aaattccaga tgaggttcga 840 catgagatag agcctcattt cgtggactct gctcccgtca ttgaagatga tgaccggaaa 900 cttcccaagc tggatgagaa gactgctgac tccatccgca agggtctaac tccgaagtgg 960 aatgacttgg atgtcaatca gcacgtcaac aacgtgaagt acattgggtg gattcttgag 1020 agtactccac cagaagttct ggagacccag gagttatgtt cccttaccct ggaatatagg 1080 cgggaatgcg gaagggagag cgtgctggag tccctcactg ctgtggaccc ctctggaaag 1140 ggctctgggt ctcagttcca gcaccttctg cggcttgagg atggaggtga gattgtgaag 1200 gggagaactg agtggcgacc caagactgca ggaatcaatg ggccaatagc atccggggag 1260 acctcacctg gagactcttc ttag 1284 <210> 18 <211> 1284 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 18 atggtggcca ccgccgcctc ctccgccttc ttccccgtgc cctcccccga cgcctcctcc 60 cgccccggca agctgggcaa cggctcctcc tccctgtccc ccctgaagcc caagctgatg 120 gccaacggcg gcctgcaggt gaaggccaac gcctccgccc cccccaagat caacggctcc 180 tccgtgggcc tgaagtccgg ctccctgaag acccaggagg acaccccctc cgcccccccc 240 ccccgcacct tcatcaacca gctgcccgac tggtccatgc tgctggccgc catcaccacc 300 gtgttcctgg ccgccgagaa gcagtggatg atgctggact ggaagcccaa gcgccccgac 360 atgctggtgg accccttcgg cctgggccgc atcgtgcagg acggcctggt gttccgccag 420 aacttctcca tccgctccta cgagatcggc gccgaccgca ccgcctccat cgagaccgtg 480 atgaaccacc tgcaggagac cgccctgaac cacgtgaagt ccgccggcct gctgaacgac 540 ggcttcggcc gcaccctgga gatgtacaag cgcgacctga tctgggtggt ggccaagatg 600 caggtgatgg tgaaccgcta ccccacctgg ggcgacaccg tggaggtgaa cacctgggtg 660 gccaagtccg gcaagaacgg catgcgccgc gactggctga tctccgactg caacaccggc 720 gagatcctga cccgcgcctc ctccaagtcc cagatcatgc tgcccctgca ctactgctcc 780 gtgtgggtga tgatgaacca gaagacccgc cgcctgtcca agatccccga cgaggtgcgc 840 cacgagatcg agccccactt cgtggactcc gcccccgtga tcgaggacga cgaccgcaag 900 ctgcccaagc tggacgagaa gaccgccgac tccatccgca agggcctgac ccccaagtgg 960 aacgacctgg acgtgaacca gcacgtgaac aacgtgaagt acatcggctg gatcctggag 1020 tccacccccc ccgaggtgct ggagacccag gagctgtgct ccctgaccct ggagtaccgc 1080 cgcgagtgcg gccgcgagtc cgtgctggag tccctgaccg ccgtggaccc ctccggcaag 1140 ggctccggct cccagttcca gcacctgctg cgcctggagg acggcggcga gatcgtgaag 1200 ggccgcaccg agtggcgccc caagaccgcc ggcatcaacg gccccatcgc ctccggcgag 1260 acctcccccg gcgactcctc ctga 1284 <210> 19 <211> 417 <212> PRT <213> Cuphea hyssopifolia <400> 19 Met Val Ala Ala Glu Ala Ser Ser Ala Leu Phe Ser Val Arg Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Thr Ser Leu 20 25 30 Ser Val Pro Phe Lys Ser Lys Ser Asn His Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Arg Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asp Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Ser Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Met Asp Pro Phe 115 120 125 Gly Val Asp Arg Val Val Gln Asp Gly Ala Val Phe Arg Gln Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Ile Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Val Thr Lys Met His Val Glu Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu 210 215 220 Ser Gly Lys Thr Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys His 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Met Cys Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu 260 265 270 Leu Ala Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Tyr Gln 275 280 285 Lys Leu His Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Cys Asn Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Val Pro Thr Glu Val Phe 325 330 335 Glu Thr Gln Glu Leu Cys Gly Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys 355 360 365 Glu Gly Asp Arg Ser Leu Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Ala Asp Ile Ala Lys Gly Arg Thr Lys Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser Ile 405 410 415 Ser <210> 20 <211> 1254 <212> DNA <213> Cuphea hyssopifolia <400> 20 atggtggctg ccgaagcaag ttctgcactc ttctccgttc gaaccccggg aacctcccct 60 aaacccggga agttcgggaa ttggccaacg agcttgagcg tccccttcaa gtccaaatca 120 aaccacaatg gcggctttca ggttaaggca aacgccagtg cccgtcctaa ggctaacggt 180 tctgcagtaa gtctaaagtc tggcagcctc gacactcagg aggacacttc atcgtcgtcc 240 tctcctcctc ggactttcat taaccagttg cccgactgga gtatgctgct gtccgcgatc 300 acgaccgtct tcgtggcggc tgagaagcag tggacgatgc ttgatcggaa atctaagagg 360 cccgacatgc tcatggaccc gtttggggtt gacagggttg ttcaggatgg ggctgtgttc 420 agacagagtt tttcgattag gtcttacgaa ataggcgctg atcgaacagc ctctatagag 480 acgctgatga acatcttcca ggaaacatct ctcaatcatt gtaagagtat cggtcttctc 540 aatgacggct ttggtcgtac tcctgagatg tgtaagaggg acctcatttg ggtggttaca 600 aaaatgcacg tcgaggttaa tcgctatcct acttggggtg atactatcga ggtcaatact 660 tgggtctccg agtcggggaa aaccggtatg ggtcgtgatt ggctgataag tgattgtcat 720 acaggagaaa ttctaataag agcaacgagc atgtgtgcta tgatgaatca aaagacgaga 780 agattctcaa aatttccata tgaggttcga caggagttgg cgcctcattt tgtggactct 840 gctcctgtca ttgaagacta tcaaaaattg cacaagcttg atgtgaagac gggtgattcc 900 atttgcaatg gcctaactcc aaggtggaat gacttggatg tcaatcagca cgttaacaat 960 gtgaagtaca ttgggtggat tctcgagagt gttccaacgg aagttttcga gacccaggag 1020 ctatgtggcc tcacccttga gtataggcgg gaatgcggaa gggacagtgt gctggagtcc 1080 gtgaccgcta tggatccatc aaaagaggga gacagatctc tgtaccagca ccttcttcgg 1140 cttgaggatg gggctgatat cgcgaagggc agaaccaagt ggcggccgaa gaatgcagga 1200 accaatgggg caatatcaac aggaaagact tcaaatggaa actcgatctc ttag 1254 <210> 21 <211> 1254 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 21 atggtggccg ccgaggcctc ctccgccctg ttctccgtgc gcacccccgg cacctccccc 60 aagcccggca agttcggcaa ctggcccacc tccctgtccg tgcccttcaa gtccaagtcc 120 aaccacaacg gcggcttcca ggtgaaggcc aacgcctccg cccgccccaa ggccaacggc 180 tccgccgtgt ccctgaagtc cggctccctg gacacccagg aggacacctc ctcctcctcc 240 tccccccccc gcaccttcat caaccagctg cccgactggt ccatgctgct gtccgccatc 300 accaccgtgt tcgtggccgc cgagaagcag tggaccatgc tggaccgcaa gtccaagcgc 360 cccgacatgc tgatggaccc cttcggcgtg gaccgcgtgg tgcaggacgg cgccgtgttc 420 cgccagtcct tctccatccg ctcctacgag atcggcgccg accgcaccgc ctccatcgag 480 accctgatga acatcttcca ggagacctcc ctgaaccact gcaagtccat cggcctgctg 540 aacgacggct tcggccgcac ccccgagatg tgcaagcgcg acctgatctg ggtggtgacc 600 aagatgcacg tggaggtgaa ccgctacccc acctggggcg acaccatcga ggtgaacacc 660 tgggtgtccg agtccggcaa gaccggcatg ggccgcgact ggctgatctc cgactgccac 720 accggcgaga tcctgatccg cgccacctcc atgtgcgcca tgatgaacca gaagacccgc 780 cgcttctcca agttccccta cgaggtgcgc caggagctgg ccccccactt cgtggactcc 840 gcccccgtga tcgaggacta ccagaagctg cacaagctgg acgtgaagac cggcgactcc 900 atctgcaacg gcctgacccc ccgctggaac gacctggacg tgaaccagca cgtgaacaac 960 gtgaagtaca tcggctggat cctggagtcc gtgcccaccg aggtgttcga gacccaggag 1020 ctgtgcggcc tgaccctgga gtaccgccgc gagtgcggcc gcgactccgt gctggagtcc 1080 gtgaccgcca tggacccctc caaggagggc gaccgctccc tgtaccagca cctgctgcgc 1140 ctggaggacg gcgccgacat cgccaagggc cgcaccaagt ggcgccccaa gaacgccggc 1200 accaacggcg ccatctccac cggcaagacc tccaacggca actccatctc ctga 1254 <210> 22 <211> 417 <212> PRT <213> Cuphea hyssopifolia <400> 22 Met Val Ala Ala Glu Ala Ser Ser Ala Leu Phe Ser Val Arg Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Thr Ser Leu 20 25 30 Ser Val Pro Phe Lys Ser Lys Ser Asn His Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Arg Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asp Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Ser Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Met Asp Pro Phe 115 120 125 Gly Val Asp Arg Val Val Gln Asp Gly Ala Val Phe Arg Gln Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Ile Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Val Thr Lys Met His Ile Glu Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu 210 215 220 Ser Gly Lys Thr Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Phe His 225 230 235 240 Thr Gly Asp Ile Leu Ile Arg Ala Thr Ser Val Cys Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu 260 265 270 Leu Ala Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Tyr Gln 275 280 285 Lys Leu His Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Cys Asn Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Val Pro Thr Glu Val Phe 325 330 335 Glu Thr Gln Glu Leu Cys Gly Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys 355 360 365 Glu Gly Asp Arg Ser Leu Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Ala Asp Ile Ala Lys Gly Arg Thr Lys Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser Ile 405 410 415 Ser <210> 23 <211> 1254 <212> DNA <213> Cuphea hyssopifolia <400> 23 atggtggctg ccgaagcaag ttctgcactc ttctccgttc gaaccccggg aacctcccct 60 aaacccggga agttcgggaa ttggccaacg agcttgagcg tccccttcaa gtccaaatca 120 aaccacaatg gcggctttca ggttaaggca aacgccagtg cccgtcctaa ggctaacggt 180 tctgcagtaa gtctaaagtc tggcagcctc gacactcagg aggacacttc atcgtcgtcc 240 tctcctcctc ggactttcat taaccagttg cccgactgga gtatgctgct gtccgcgatc 300 acgaccgtct tcgtggcggc tgagaagcag tggacgatgc ttgatcggaa atctaagagg 360 cccgacatgc tcatggaccc gtttggggtt gacagggttg ttcaggatgg ggctgtgttc 420 agacagagtt tttcgattag gtcttacgaa ataggcgctg atcgaacagc ctctatagag 480 acgctgatga acatcttcca ggaaacatct ctcaatcatt gtaagagtat cggtcttctc 540 aatgacggct ttggtcgtac tcctgagatg tgtaagaggg acctcatttg ggtggttaca 600 aaaatgcaca tcgaggttaa tcgctatcct acttggggtg atactatcga ggtcaatact 660 tgggtctccg agtcggggaa aaccggtatg ggtcgtgatt ggctgataag tgattttcat 720 acaggagaca ttctaataag agcaacgagc gtgtgtgcta tgatgaatca aaagacgaga 780 agattctcaa aatttccata tgaggttcga caggagttag cgcctcattt tgtggactct 840 gctccagtca ttgaagacta tcaaaaattg cacaagcttg atgtgaagac gggtgattcc 900 atttgcaatg gcctaactcc aaggtggaat gacttggatg tcaatcagca cgttaacaat 960 gtgaagtaca ttgggtggat tctcgagagt gttccaacgg aagttttcga gacccaggag 1020 ctatgtggcc tcacccttga gtataggcgg gaatgcggaa gggacagtgt gctggagtcc 1080 gtgaccgcta tggatccctc aaaagaggga gacagatctc tgtaccagca ccttcttcgg 1140 cttgaggatg gggctgatat cgcgaagggc agaaccaagt ggcggccgaa gaatgcagga 1200 accaatgggg caatatcaac aggaaagact tcaaatggaa actcgatctc ttag 1254 <210> 24 <211> 1254 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 24 atggtggccg ccgaggcctc ctccgccctg ttctccgtgc gcacccccgg cacctccccc 60 aagcccggca agttcggcaa ctggcccacc tccctgtccg tgcccttcaa gtccaagtcc 120 aaccacaacg gcggcttcca ggtgaaggcc aacgcctccg cccgccccaa ggccaacggc 180 tccgccgtgt ccctgaagtc cggctccctg gacacccagg aggacacctc ctcctcctcc 240 tccccccccc gcaccttcat caaccagctg cccgactggt ccatgctgct gtccgccatc 300 accaccgtgt tcgtggccgc cgagaagcag tggaccatgc tggaccgcaa gtccaagcgc 360 cccgacatgc tgatggaccc cttcggcgtg gaccgcgtgg tgcaggacgg cgccgtgttc 420 cgccagtcct tctccatccg ctcctacgag atcggcgccg accgcaccgc ctccatcgag 480 accctgatga acatcttcca ggagacctcc ctgaaccact gcaagtccat cggcctgctg 540 aacgacggct tcggccgcac ccccgagatg tgcaagcgcg acctgatctg ggtggtgacc 600 aagatgcaca tcgaggtgaa ccgctacccc acctggggcg acaccatcga ggtgaacacc 660 tgggtgtccg agtccggcaa gaccggcatg ggccgcgact ggctgatctc cgacttccac 720 accggcgaca tcctgatccg cgccacctcc gtgtgcgcca tgatgaacca gaagacccgc 780 cgcttctcca agttccccta cgaggtgcgc caggagctgg ccccccactt cgtggactcc 840 gcccccgtga tcgaggacta ccagaagctg cacaagctgg acgtgaagac cggcgactcc 900 atctgcaacg gcctgacccc ccgctggaac gacctggacg tgaaccagca cgtgaacaac 960 gtgaagtaca tcggctggat cctggagtcc gtgcccaccg aggtgttcga gacccaggag 1020 ctgtgcggcc tgaccctgga gtaccgccgc gagtgcggcc gcgactccgt gctggagtcc 1080 gtgaccgcca tggacccctc caaggagggc gaccgctccc tgtaccagca cctgctgcgc 1140 ctggaggacg gcgccgacat cgccaagggc cgcaccaagt ggcgccccaa gaacgccggc 1200 accaacggcg ccatctccac cggcaagacc tccaacggca actccatctc ctga 1254 <210> 25 <211> 419 <212> PRT <213> Cuphea sp. <400> 25 Met Val Val Ala Ala Ala Thr Ser Ala Phe Phe Pro Val Pro Ala Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Ser Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Pro Thr Phe Lys Pro Lys Ser Ile Pro Asn Ala Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Ser Val Gly 115 120 125 Leu Lys Cys Ile Val Arg Asp Gly Leu Val Ser Arg Gln Ser Phe Leu 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His Cys Lys Ser Leu 165 170 175 Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly Met Cys Lys Asn 180 185 190 Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg Tyr 195 200 205 Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser Gln Ser 210 215 220 Gly Lys Ile Gly Met Ala Ser Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val Arg Gln Glu Leu 260 265 270 Thr Pro His Phe Val Asp Ser Pro His Val Ile Glu Asp Asn Asp Gln 275 280 285 Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Ser Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Ile Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Val Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Met Asp Ser Val Leu Glu Ser Val Thr Ala Val Asp Pro Ser Glu 355 360 365 Asn Gly Gly Arg Ser Gln Tyr Lys His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Ile Val Lys Ser Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Ala Ile Ser Thr Ser Thr Ala Lys Thr Ser Asn Gly Asn 405 410 415 Ser Val Ser <210> 26 <211> 1260 <212> DNA <213> Cuphea sp. <400> 26 atggtggtgg ctgcagcaac ttctgcattc ttccccgttc cagccccggg aacctcccct 60 aaacccggga agtccggcaa ctggccatcg agcttgagcc ctaccttcaa gcccaagtca 120 atccccaatg ccggatttca ggttaaggca aatgccagtg cccatcctaa ggctaacggt 180 tctgcagtaa atctaaagtc tggcagcctc aacactcagg aggacacttc gtcgtcccct 240 cctccccggg ctttccttaa ccagttgcct gattggagta tgcttctgac tgcaatcacg 300 accgtcttcg tggcggcaga gaagcagtgg actatgcttg ataggaaatc taagaggcct 360 gacatgctcg tggactcggt tgggttgaag tgtattgttc gggatgggct cgtgtccaga 420 cagagttttt tgattagatc ttatgaaata ggcgctgatc gaacagcctc tatagagacg 480 ctgatgaacc acttgcagga aacatctatc aatcattgta agagtttggg tcttctcaat 540 gacggctttg gtcgtactcc tgggatgtgt aaaaacgacc tcatttgggt gcttacaaaa 600 atgcagatca tggtgaatcg ctacccaact tggggcgata ctgttgagat caatacctgg 660 ttctctcagt cggggaaaat cggtatggct agcgattggc taataagtga ttgcaacaca 720 ggagaaattc ttataagagc aacgagcgtg tgggctatga tgaatcaaaa gacgagaaga 780 ttctcaagac ttccatacga ggttcgccag gagttaacgc ctcattttgt ggactctcct 840 catgtcattg aagacaatga tcagaaattg cataagtttg atgtgaagac tggtgattcc 900 attcgcaagg gtctaactcc gaggtggaac gacttggatg tgaatcagca cgtaagcaac 960 gtgaagtaca ttgggtggat tctcgagagt atgccaatag aagttttgga gacacaggag 1020 ctatgctctc tcaccgtaga atataggcgg gaatgcggaa tggacagtgt gctggagtcc 1080 gtgactgctg tggatccctc agaaaatgga ggccggtctc agtacaagca ccttctgcgg 1140 cttgaggatg ggactgatat cgtgaagagc agaactgagt ggcgaccgaa gaatgcagga 1200 actaacgggg cgatatcaac atcaacagca aagacttcaa atggaaactc ggtctcttag 1260 <210> 27 <211> 1260 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 27 atggtggtgg ccgccgccac ctccgccttc ttccccgtgc ccgcccccgg cacctccccc 60 aagcccggca agtccggcaa ctggccctcc tccctgtccc ccaccttcaa gcccaagtcc 120 atccccaacg ccggcttcca ggtgaaggcc aacgcctccg cccaccccaa ggccaacggc 180 tccgccgtga acctgaagtc cggctccctg aacacccagg aggacacctc ctcctccccc 240 cccccccgcg ccttcctgaa ccagctgccc gactggtcca tgctgctgac cgccatcacc 300 accgtgttcg tggccgccga gaagcagtgg accatgctgg accgcaagtc caagcgcccc 360 gacatgctgg tggactccgt gggcctgaag tgcatcgtgc gcgacggcct ggtgtcccgc 420 cagtccttcc tgatccgctc ctacgagatc ggcgccgacc gcaccgcctc catcgagacc 480 ctgatgaacc acctgcagga gacctccatc aaccactgca agtccctggg cctgctgaac 540 gacggcttcg gccgcacccc cggcatgtgc aagaacgacc tgatctgggt gctgaccaag 600 atgcagatca tggtgaaccg ctaccccacc tggggcgaca ccgtggagat caacacctgg 660 ttctcccagt ccggcaagat cggcatggcc tccgactggc tgatctccga ctgcaacacc 720 ggcgagatcc tgatccgcgc cacctccgtg tgggccatga tgaaccagaa gacccgccgc 780 ttctcccgcc tgccctacga ggtgcgccag gagctgaccc cccacttcgt ggactccccc 840 cacgtgatcg aggacaacga ccagaagctg cacaagttcg acgtgaagac cggcgactcc 900 atccgcaagg gcctgacccc ccgctggaac gacctggacg tgaaccagca cgtgtccaac 960 gtgaagtaca tcggctggat cctggagtcc atgcccatcg aggtgctgga gacccaggag 1020 ctgtgctccc tgaccgtgga gtaccgccgc gagtgcggca tggactccgt gctggagtcc 1080 gtgaccgccg tggacccctc cgagaacggc ggccgctccc agtacaagca cctgctgcgc 1140 ctggaggacg gcaccgacat cgtgaagtcc cgcaccgagt ggcgccccaa gaacgccggc 1200 accaacggcg ccatctccac ctccaccgcc aagacctcca acggcaactc cgtgtcctga 1260 <210> 28 <211> 408 <212> PRT <213> Cuphea wrightii <400> 28 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Pro Arg Thr Thr Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser 20 25 30 Leu Ser Pro Pro Phe Lys Pro Lys Ser Asn Pro Asn Gly Arg Phe Gln 35 40 45 Val Lys Ala Asn Val Ser Pro His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Leu Glu Asp Pro Pro Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Arg Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Phe Thr 100 105 110 Arg Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Trp Phe 115 120 125 Gly Ser Glu Thr Ile Val Gln Asp Gly Leu Val Phe Arg Glu Arg Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn His Leu Gln Asp Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Val Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Ser Glu Met Cys Thr 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Val Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Val Arg Ala Thr Ser Ala Trp Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Leu Pro Cys Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Cys Lys 290 295 300 Gly Leu Thr Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val 325 330 335 Leu Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Glu Ser Val Val Glu Ser Val Thr Ser Met Asn Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Ala Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Arg Ala Ile Ser Thr 405 <210> 29 <211> 1227 <212> DNA <213> Cuphea wrightii <400> 29 atggtggtgg ctgctgcagc aagttctgca ttcttccctg ttccagcacc tagaaccacg 60 cctaaacccg ggaagttcgg caattggcca tcgagcttga gcccgccctt caagcccaag 120 tcaaacccca atggtagatt tcaggttaag gcaaatgtca gtcctcatcc taaggctaac 180 ggttctgcag taagtctaaa gtctggcagc ctcaacactc tggaggaccc tccgtcgtcc 240 cctcctcctc ggactttcct taaccagttg cctgattgga gtaggcttcg gactgcaatc 300 acgaccgtct tcgtggcggc agagaagcag ttcactaggc tcgatcgaaa atctaagagg 360 cctgacatgc tagtggactg gtttgggtca gagactattg ttcaggatgg gctcgtgttc 420 agagagagat tttcgatcag gtcttacgaa ataggcgctg atcgaacagc ctctatagag 480 acgctgatga accacttgca ggacacatct ctgaatcatt gtaagagtgt gggtcttctc 540 aatgacggct ttggtcgtac ctcggagatg tgtacaagag acctcatttg ggtgcttaca 600 aaaatgcaga tcgtggtgaa tcgctatcca acttggggcg atactgtcga gatcaatagc 660 tggttctccc agtcggggaa aatcggtatg ggtcgcgatt ggctaataag tgattgcaac 720 acaggagaaa ttcttgtaag agcaacgagc gcttgggcca tgatgaatca aaagacgaga 780 agattctcaa aacttccatg cgaggttcgc caggagatag cgcctcattt tgtggacgct 840 cctcctgtca ttgaagacaa tgatcggaaa ttgcataagt ttgatgtgaa gactggtgat 900 tccatttgca agggtctaac tccggggtgg aatgacttgg atgtcaatca gcacgtaagc 960 aacgtgaagt acattgggtg gattctcgag agtatgccta cagaagtttt ggagacccag 1020 gagctatgct ctctcaccct tgaatatagg cgggaatgtg gaagggaaag tgtggtagag 1080 tccgtgacct ctatgaatcc ctcaaaagtt ggagaccggt ctcagtacca acaccttctg 1140 cggcttgagg atggggctga tatcatgaag ggcagaactg agtggagacc aaagaatgca 1200 ggaaccaacc gggcgatatc aacatga 1227 <210> 30 <211> 1227 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 30 atggtggtgg ccgccgccgc ctcctccgcc ttcttccccg tgcccgcccc ccgcaccacc 60 cccaagcccg gcaagttcgg caactggccc tcctccctgt cccccccctt caagcccaag 120 tccaacccca acggccgctt ccaggtgaag gccaacgtgt ccccccaccc caaggccaac 180 ggctccgccg tgtccctgaa gtccggctcc ctgaacaccc tggaggaccc cccctcctcc 240 cccccccccc gcaccttcct gaaccagctg cccgactggt cccgcctgcg caccgccatc 300 accaccgtgt tcgtggccgc cgagaagcag ttcacccgcc tggaccgcaa gtccaagcgc 360 cccgacatgc tggtggactg gttcggctcc gagaccatcg tgcaggacgg cctggtgttc 420 cgcgagcgct tctccatccg ctcctacgag atcggcgccg accgcaccgc ctccatcgag 480 accctgatga accacctgca ggacacctcc ctgaaccact gcaagtccgt gggcctgctg 540 aacgacggct tcggccgcac ctccgagatg tgcacccgcg acctgatctg ggtgctgacc 600 aagatgcaga tcgtggtgaa ccgctacccc acctggggcg acaccgtgga gatcaactcc 660 tggttctccc agtccggcaa gatcggcatg ggccgcgact ggctgatctc cgactgcaac 720 accggcgaga tcctggtgcg cgccacctcc gcctgggcca tgatgaacca gaagacccgc 780 cgcttctcca agctgccctg cgaggtgcgc caggagatcg ccccccactt cgtggacgcc 840 ccccccgtga tcgaggacaa cgaccgcaag ctgcacaagt tcgacgtgaa gaccggcgac 900 tccatctgca agggcctgac ccccggctgg aacgacctgg acgtgaacca gcacgtgtcc 960 aacgtgaagt acatcggctg gatcctggag tccatgccca ccgaggtgct ggagacccag 1020 gagctgtgct ccctgaccct ggagtaccgc cgcgagtgcg gccgcgagtc cgtggtggag 1080 tccgtgacct ccatgaaccc ctccaaggtg ggcgaccgct cccagtacca gcacctgctg 1140 cgcctggagg acggcgccga catcatgaag ggccgcaccg agtggcgccc caagaacgcc 1200 ggcaccaacc gcgccatctc cacctga 1227 <210> 31 <211> 416 <212> PRT <213> Cuphea wrightii <400> 31 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Ala 1 5 10 15 Asp Thr Ser Ser Ser Arg Pro Gly Lys Leu Gly Ser Gly Pro Ser Ser 20 25 30 Leu Ser Pro Leu Lys Pro Lys Ser Ile Pro Asn Gly Gly Leu Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly 50 55 60 Leu Lys Ser Gly Gly Phe Lys Thr Gln Glu Asp Ser Pro Ser Ala Pro 65 70 75 80 Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ala Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met 100 105 110 Leu Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly 115 120 125 Leu Gly Ser Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Val Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ile Ala 165 170 175 Gly Leu Ser Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg 180 185 190 Asp Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr 195 200 205 Pro Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser 210 215 220 Gly Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg Asn Glu Ile 260 265 270 Glu Pro His Phe Val Asp Ser Ala Pro Val Val Glu Asp Asp Asp Arg 275 280 285 Lys Leu Pro Lys Leu Asp Glu Asn Thr Ala Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Ala 355 360 365 Glu Gly Tyr Ala Ser Arg Phe Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Gly Glu Ile Val Lys Ala Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Ile Asn Gly Val Val Pro Ser Glu Glu Ser Ser Pro Gly Asp Phe Phe 405 410 415 <210> 32 <211> 1251 <212> DNA <213> Cuphea wrightii <400> 32 ttggtggcta ccgctgcaag ttctgcattt ttccccgtgc catccgccga cacctcctcc 60 tcgagacccg gaaagctcgg cagtggacca tcgagcttga gccccctcaa gcccaaatcg 120 atccccaatg gcggcttgca ggttaaggca aacgccagtg cccctcctaa gatcaatggt 180 tcctcggtcg gtctaaagtc gggcggtttc aagactcagg aagactctcc ttcggcccct 240 cctccgcgga cttttatcaa ccagttgcct gattggagta tgcttcttgc tgcaatcact 300 actgtcttct tggctgcaga gaagcagtgg atgatgcttg attggaaacc taagaggcct 360 gacatgctcg tggacccgtt cggattggga agtattgttc aggatgggct tgtgttcagg 420 cagaattttt caattaggtc ctacgaaata ggcgccgatc gaactgcgtc tatagagacg 480 gtgatgaacc atttgcagga aacagctctc aatcatgtca agattgctgg gctttctaat 540 gacggctttg gtcgtactcc tgagatgtat aaaagagacc ttatttgggt tgttgcaaaa 600 atgcaggtca tggttaaccg ctatcctact tggggtgaca cggttgaagt gaatacttgg 660 gttgccaagt cagggaaaaa tggtatgcgt cgtgactggc tcataagtga ttgcaatact 720 ggagagattc ttacaagagc atcaagcgtg tgggtcatga tgaatcaaaa gacaagaaga 780 ttgtcaaaaa ttccagatga ggttcgaaat gagatagagc ctcattttgt ggactctgct 840 cccgtcgttg aagatgatga tcggaaactt cccaagctgg atgagaacac tgctgactcc 900 atccgcaagg gtctaactcc gaggtggaat gacttggatg tcaatcagca cgtcaacaac 960 gtgaagtaca tcggatggat tcttgagagt actccaccag aagttctgga gacccaggag 1020 ttatgctccc tgaccctgga atacaggcgg gaatgtggaa gggagagcgt gctggagtcc 1080 ctcactgctg tcgacccgtc tgcagagggc tatgcgtccc ggtttcagca ccttctgcgg 1140 cttgaggatg gaggtgagat cgtgaaggcg agaactgagt ggcgacccaa gaatgctgga 1200 atcaatgggg tggtaccatc cgaggagtcc tcacctggag acttctttta g 1251 <210> 33 <211> 1251 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 33 atggtggcca ccgccgcctc ctccgccttc ttccccgtgc cctccgccga cacctcctcc 60 tcccgccccg gcaagctggg ctccggcccc tcctccctgt cccccctgaa gcccaagtcc 120 atccccaacg gcggcctgca ggtgaaggcc aacgcctccg ccccccccaa gatcaacggc 180 tcctccgtgg gcctgaagtc cggcggcttc aagacccagg aggactcccc ctccgccccc 240 cccccccgca ccttcatcaa ccagctgccc gactggtcca tgctgctggc cgccatcacc 300 accgtgttcc tggccgccga gaagcagtgg atgatgctgg actggaagcc caagcgcccc 360 gacatgctgg tggacccctt cggcctgggc tccatcgtgc aggacggcct ggtgttccgc 420 cagaacttct ccatccgctc ctacgagatc ggcgccgacc gcaccgcctc catcgagacc 480 gtgatgaacc acctgcagga gaccgccctg aaccacgtga agatcgccgg cctgtccaac 540 gacggcttcg gccgcacccc cgagatgtac aagcgcgacc tgatctgggt ggtggccaag 600 atgcaggtga tggtgaaccg ctaccccacc tggggcgaca ccgtggaggt gaacacctgg 660 gtggccaagt ccggcaagaa cggcatgcgc cgcgactggc tgatctccga ctgcaacacc 720 ggcgagatcc tgacccgcgc ctcctccgtg tgggtgatga tgaaccagaa gacccgccgc 780 ctgtccaaga tccccgacga ggtgcgcaac gagatcgagc cccacttcgt ggactccgcc 840 cccgtggtgg aggacgacga ccgcaagctg cccaagctgg acgagaacac cgccgactcc 900 atccgcaagg gcctgacccc ccgctggaac gacctggacg tgaaccagca cgtgaacaac 960 gtgaagtaca tcggctggat cctggagtcc accccccccg aggtgctgga gacccaggag 1020 ctgtgctccc tgaccctgga gtaccgccgc gagtgcggcc gcgagtccgt gctggagtcc 1080 ctgaccgccg tggacccctc cgccgagggc tacgcctccc gcttccagca cctgctgcgc 1140 ctggaggacg gcggcgagat cgtgaaggcc cgcaccgagt ggcgccccaa gaacgccggc 1200 atcaacggcg tggtgccctc cgaggagtcc tcccccggcg acttcttctg a 1251 <210> 34 <211> 417 <212> PRT <213> Cuphea wrightii <400> 34 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Ala 1 5 10 15 Asp Thr Ser Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Pro Ser Ser 20 25 30 Leu Ser Pro Leu Lys Pro Lys Ser Ile Pro Asn Gly Gly Leu Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly 50 55 60 Leu Lys Ser Gly Ser Phe Lys Thr Gln Glu Asp Ala Pro Ser Ala Pro 65 70 75 80 Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ala Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met 100 105 110 Leu Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly 115 120 125 Leu Gly Ser Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Val Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ile Ala 165 170 175 Gly Leu Ser Ser Asp Gly Phe Gly Arg Thr Pro Ala Met Ser Lys Arg 180 185 190 Asp Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr 195 200 205 Pro Ala Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser 210 215 220 Gly Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg Asn Glu Ile 260 265 270 Glu Pro His Phe Val Asp Ser Ala Pro Val Val Glu Asp Asp Asp Arg 275 280 285 Lys Leu Pro Lys Leu Asp Glu Asn Thr Ala Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Ala Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly 355 360 365 Glu Gly Asp Gly Ser Lys Phe Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Gly Glu Ile Val Lys Ala Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Ile Asn Gly Val Val Pro Ser Glu Glu Ser Ser Pro Gly Gly Asp Phe 405 410 415 Phe <210> 35 <211> 1254 <212> DNA <213> Cuphea wrightii <400> 35 ttggtggcta ccgctgcaag ttctgcattt ttccccgtac catccgccga cacctcctca 60 tcgagacccg gaaagctcgg caatgggcca tcgagcttga gccccctcaa gccgaaatcg 120 atccccaatg gcgggttgca ggttaaggca aacgccagtg cccctcctaa gatcaatggt 180 tcctcggtcg gtctgaagtc gggcagtttc aagactcagg aagacgctcc ttcggcccct 240 cctcctcgga cttttatcaa ccagttgcct gattggagta tgcttcttgc tgcaatcact 300 actgtcttct tggctgcaga gaagcagtgg atgatgcttg attggaaacc taagaggcct 360 gacatgcttg tcgacccgtt cggattggga agtattgttc aggatgggct tgttttcagg 420 cagaatttct cgattaggtc ctacgaaata ggcgctgatc gcactgcgtc tatagagacg 480 gtgatgaacc atttgcagga aacagctctc aatcatgtta agattgctgg gctttctagt 540 gatggctttg gtcgtactcc tgcgatgtct aaacgggacc tcatttgggt tgttgcgaaa 600 atgcaggtca tggttaaccg ctaccctgct tggggtgaca cggttgaagt gaatacttgg 660 gttgccaagt cagggaaaaa tggtatgcgt cgtgactggc tcataagtga ttgcaacact 720 ggagagattc ttacaagagc atcaagcgtg tgggtcatga tgaatcaaaa gacaagaaga 780 ttgtcaaaaa ttccagatga ggttcgaaat gagatagagc ctcattttgt ggactctgcg 840 cccgtcgttg aagacgatga ccggaaactt cccaagctgg atgagaacac tgctgactcc 900 atccgcaagg gtctaactcc gaggtggaat gacttggatg tcaatcagca cgtcaacaac 960 gtgaagtaca ttgggtggat tcttgagagt actccagcag aagttctgga gacccaggaa 1020 ttatgttccc tgaccctgga atacaggcgg gaatgtggaa gggagagcgt gctggagtcc 1080 ctcactgctg tagatccgtc tggagagggc gatgggtcca agttccagca ccttctgcgg 1140 cttgaggatg gaggtgagat cgtgaaggcg agaactgagt ggcgaccaaa gaatgctgga 1200 atcaatgggg tggtaccatc cgaggagtcc tcacctggtg gagacttctt ttaa 1254 <210> 36 <211> 1254 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 36 atggtggcca ccgccgcctc ctccgccttc ttccccgtgc cctccgccga cacctcctcc 60 tcccgccccg gcaagctggg caacggcccc tcctccctgt cccccctgaa gcccaagtcc 120 atccccaacg gcggcctgca ggtgaaggcc aacgcctccg ccccccccaa gatcaacggc 180 tcctccgtgg gcctgaagtc cggctccttc aagacccagg aggacgcccc ctccgccccc 240 cccccccgca ccttcatcaa ccagctgccc gactggtcca tgctgctggc cgccatcacc 300 accgtgttcc tggccgccga gaagcagtgg atgatgctgg actggaagcc caagcgcccc 360 gacatgctgg tggacccctt cggcctgggc tccatcgtgc aggacggcct ggtgttccgc 420 cagaacttct ccatccgctc ctacgagatc ggcgccgacc gcaccgcctc catcgagacc 480 gtgatgaacc acctgcagga gaccgccctg aaccacgtga agatcgccgg cctgtcctcc 540 gacggcttcg gccgcacccc cgccatgtcc aagcgcgacc tgatctgggt ggtggccaag 600 atgcaggtga tggtgaaccg ctaccccgcc tggggcgaca ccgtggaggt gaacacctgg 660 gtggccaagt ccggcaagaa cggcatgcgc cgcgactggc tgatctccga ctgcaacacc 720 ggcgagatcc tgacccgcgc ctcctccgtg tgggtgatga tgaaccagaa gacccgccgc 780 ctgtccaaga tccccgacga ggtgcgcaac gagatcgagc cccacttcgt ggactccgcc 840 cccgtggtgg aggacgacga ccgcaagctg cccaagctgg acgagaacac cgccgactcc 900 atccgcaagg gcctgacccc ccgctggaac gacctggacg tgaaccagca cgtgaacaac 960 gtgaagtaca tcggctggat cctggagtcc acccccgccg aggtgctgga gacccaggag 1020 ctgtgctccc tgaccctgga gtaccgccgc gagtgcggcc gcgagtccgt gctggagtcc 1080 ctgaccgccg tggacccctc cggcgagggc gacggctcca agttccagca cctgctgcgc 1140 ctggaggacg gcggcgagat cgtgaaggcc cgcaccgagt ggcgccccaa gaacgccggc 1200 atcaacggcg tggtgccctc cgaggagtcc tcccccggcg gcgacttctt ctga 1254 <210> 37 <211> 413 <212> PRT <213> Cuphea wrightii <400> 37 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Pro 1 5 10 15 Gly Thr Pro Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Pro Asp Asn Gly Gly Phe His Val Lys Ala Asn 35 40 45 Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn Leu Lys Ser 50 55 60 Gly Ser Leu Glu Thr Pro Pro Arg Ser Phe Ile Asn Gln Leu Pro Asp 65 70 75 80 Leu Ser Val Leu Leu Ser Lys Ile Thr Thr Val Phe Gly Ala Ala Glu 85 90 95 Lys Gln Trp Lys Arg Pro Gly Met Leu Val Glu Pro Phe Gly Val Asp 100 105 110 Arg Ile Phe Gln Asp Gly Val Phe Phe Arg Gln Ser Phe Ser Ile Arg 115 120 125 Ser Tyr Glu Ile Gly Val Asp Arg Thr Ala Ser Ile Glu Thr Leu Met 130 135 140 Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser Ile Gly Leu 145 150 155 160 Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu 165 170 175 Ile Trp Val Val Thr Lys Ile Gln Val Glu Val Asn Arg Tyr Pro Thr 180 185 190 Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu Ser Gly Lys 195 200 205 Asn Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Arg Thr Gly Glu 210 215 220 Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln Asn Thr 225 230 235 240 Arg Arg Leu Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro 245 250 255 His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Gln Lys Leu Gln 260 265 270 Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Arg Asp Gly Leu Thr Pro 275 280 285 Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val Lys Tyr 290 295 300 Ile Gly Trp Ile Leu Lys Ser Val Pro Ile Glu Val Phe Glu Thr Gln 305 310 315 320 Glu Leu Cys Gly Val Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg Asp 325 330 335 Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ala Lys Glu Gly Asp 340 345 350 Arg Cys Val Tyr Gln His Leu Leu Arg Leu Glu Asp Gly Ala Asp Ile 355 360 365 Thr Ile Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn Gly 370 375 380 Ala Met Ser Ser Gly Lys Thr Ser Asn Gly Asn Cys Leu Ile Glu Gly 385 390 395 400 Arg Gly Trp Gln Pro Phe Arg Val Val Arg Leu Ile Phe 405 410 <210> 38 <211> 1242 <212> DNA <213> Cuphea wrightii <400> 38 atggtggctg ccgcagcaag ttctgcattc ttctctgttc caaccccggg aacgccccct 60 aaacccggga agttcggtaa ctggccatcg agcttgagcg tccccttcaa gcccgacaat 120 ggtggctttc atgtcaaggc aaacgccagt gcccatccta aggctaatgg ttctgcggta 180 aatctaaagt ctggcagcct cgagactcct cctcggagtt tcattaacca gctgccggac 240 ttgagtgtgc ttctgtccaa aatcacgact gtcttcgggg cggctgagaa gcagtggaag 300 aggcccggca tgctcgtgga accgtttggg gttgacagga tttttcagga tggtgttttt 360 ttcagacaga gtttttctat caggtcttac gaaataggcg ttgatcgaac agcctcgata 420 gagacactga tgaacatctt ccaggaaaca tctttgaatc attgcaagag tatcggtctt 480 ctcaacgatg gctttggtcg tactcctgag atgtgtaaga gggacctcat ttgggtggtt 540 acgaaaattc aggtcgaggt gaatcgctat cctacttggg gtgacactat cgaagtcaat 600 acttgggtct cggagtcggg gaaaaacggt atgggtcggg attggctgat aagtgattgc 660 cgtactggag agattcttat aagagcaacg agcgtgtggg cgatgatgaa tcaaaacacg 720 agaagattgt caaaatttcc atatgaggtt cgacaggaga tagcgcctca ttttgtggac 780 tctgctcctg tcattgaaga cgatcaaaag ttgcagaagc ttgatgtgaa gacaggtgat 840 tccattcgcg atggtctaac tccgagatgg aatgacttgg atgtcaatca acacgttaac 900 aatgtgaagt acattggatg gattctcaag agtgttccaa tagaagtttt cgagacacag 960 gagctatgcg gcgtcacact tgaatatagg cgggaatgcg gaagggacag tgtgctggag 1020 tcagtgaccg ctatggatcc agcaaaagag ggagaccggt gtgtgtacca gcaccttctt 1080 cggcttgagg atggagctga tatcactata ggcagaaccg agtggcggcc gaagaatgca 1140 ggagccaatg gtgcaatgtc atcaggaaag acttcaaatg gaaactgtct catagaagga 1200 aggggttggc aacctttccg agttgtgcgt ttaattttct ga 1242 <210> 39 <211> 1242 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 39 atggtggccg ccgccgcctc ctccgccttc ttctccgtgc ccacccccgg cacccccccc 60 aagcccggca agttcggcaa ctggccctcc tccctgtccg tgcccttcaa gcccgacaac 120 ggcggcttcc acgtgaaggc caacgcctcc gcccacccca aggccaacgg ctccgccgtg 180 aacctgaagt ccggctccct ggagaccccc ccccgctcct tcatcaacca gctgcccgac 240 ctgtccgtgc tgctgtccaa gatcaccacc gtgttcggcg ccgccgagaa gcagtggaag 300 cgccccggca tgctggtgga gcccttcggc gtggaccgca tcttccagga cggcgtgttc 360 ttccgccagt ccttctccat ccgctcctac gagatcggcg tggaccgcac cgcctccatc 420 gagaccctga tgaacatctt ccaggagacc tccctgaacc actgcaagtc catcggcctg 480 ctgaacgacg gcttcggccg cacccccgag atgtgcaagc gcgacctgat ctgggtggtg 540 accaagatcc aggtggaggt gaaccgctac cccacctggg gcgacaccat cgaggtgaac 600 acctgggtgt ccgagtccgg caagaacggc atgggccgcg actggctgat ctccgactgc 660 cgcaccggcg agatcctgat ccgcgccacc tccgtgtggg ccatgatgaa ccagaacacc 720 cgccgcctgt ccaagttccc ctacgaggtg cgccaggaga tcgcccccca cttcgtggac 780 tccgcccccg tgatcgagga cgaccagaag ctgcagaagc tggacgtgaa gaccggcgac 840 tccatccgcg acggcctgac cccccgctgg aacgacctgg acgtgaacca gcacgtgaac 900 aacgtgaagt acatcggctg gatcctgaag tccgtgccca tcgaggtgtt cgagacccag 960 gagctgtgcg gcgtgaccct ggagtaccgc cgcgagtgcg gccgcgactc cgtgctggag 1020 tccgtgaccg ccatggaccc cgccaaggag ggcgaccgct gcgtgtacca gcacctgctg 1080 cgcctggagg acggcgccga catcaccatc ggccgcaccg agtggcgccc caagaacgcc 1140 ggcgccaacg gcgccatgtc ctccggcaag acctccaacg gcaactgcct gatcgagggc 1200 cgcggctggc agcccttccg cgtggtgcgc ctgatcttct ga 1242 <210> 40 <211> 410 <212> PRT <213> Cuphea heterophylla <400> 40 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Pro 1 5 10 15 Gly Thr Ser Thr Lys Pro Gly Asn Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Pro Glu Ser Asn His Asn Gly Gly Phe Arg Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Glu Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Ile Lys Gln Leu Pro Asp Trp Gly Met Leu 85 90 95 Leu Ser Lys Ile Thr Thr Val Phe Gly Ala Ala Glu Arg Gln Trp Lys 100 105 110 Arg Pro Gly Met Leu Val Glu Pro Phe Gly Val Asp Arg Ile Phe Gln 115 120 125 Asp Gly Val Phe Phe Arg Gln Ser Phe Ser Ile Arg Ser Tyr Glu Ile 130 135 140 Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Leu Met Asn Ile Phe Gln 145 150 155 160 Glu Thr Ser Leu Asn His Cys Lys Ser Ile Gly Leu Leu Asn Asp Gly 165 170 175 Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu Ile Trp Val Val 180 185 190 Thr Lys Ile Gln Val Glu Val Asn Arg Tyr Pro Thr Trp Gly Asp Thr 195 200 205 Ile Glu Val Asn Thr Trp Val Ser Glu Ser Gly Lys Asn Gly Met Gly 210 215 220 Arg Asp Trp Leu Ile Ser Asp Cys Arg Thr Gly Glu Ile Leu Ile Arg 225 230 235 240 Ala Thr Ser Val Trp Ala Met Met Asn Arg Lys Thr Arg Arg Leu Ser 245 250 255 Lys Phe Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro His Phe Val Asp 260 265 270 Ser Ala Pro Val Ile Glu Asp Asp Lys Lys Leu His Lys Leu Asp Val 275 280 285 Lys Thr Gly Asp Ser Ile Arg Lys Gly Leu Thr Pro Arg Trp Asn Asp 290 295 300 Leu Asp Val Asn Gln His Val Asn Asn Val Lys Tyr Ile Gly Trp Ile 305 310 315 320 Leu Lys Ser Val Pro Ala Glu Val Phe Glu Thr Gln Glu Leu Cys Gly 325 330 335 Val Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg Asp Ser Val Leu Glu 340 345 350 Ser Val Thr Ala Met Asp Thr Ala Lys Glu Gly Asp Arg Ser Leu Tyr 355 360 365 Gln His Leu Leu Arg Leu Glu Asp Gly Ala Asp Ile Thr Ile Gly Arg 370 375 380 Thr Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn Gly Ala Ile Ser Thr 385 390 395 400 Gly Lys Thr Ser Asn Glu Asn Ser Val Ser 405 410 <210> 41 <211> 1233 <212> DNA <213> Cuphea heterophylla <400> 41 atggtggctg ccgcagcaag ttctgcattc ttctccgttc caaccccggg aacctccact 60 aaacccggga acttcggcaa ttggccatcg agcttgagcg tccccttcaa gcccgaatca 120 aaccacaatg gtggctttcg ggtcaaggca aacgccagtg ctcatcctaa ggctaacggt 180 tctgcagtaa atctaaagtc tggcagcctc gagactcagg aggacacttc atcgtcgtcc 240 cctcctcctc ggacttttat taagcagttg cccgactggg gtatgcttct gtccaaaatc 300 acgactgtct tcggggcggc tgagaggcag tggaagaggc ccggcatgct tgtggaaccg 360 tttggggttg acaggatttt tcaggatggg gtttttttca gacagagttt ttcgatcagg 420 tcttacgaaa taggcgctga tcgaacagcc tcaatagaga cgctgatgaa catcttccag 480 gaaacatctc tgaatcattg taagagtatc ggtcttctca atgacggctt tggtcgtact 540 cctgagatgt gtaagaggga cctcatttgg gtggttacga aaattcaggt cgaggtgaat 600 cgctatccta cttggggtga tactattgag gtcaatactt gggtctcaga gtcggggaaa 660 aacggtatgg gtcgtgattg gctgataagc gattgccgta ccggagaaat tcttataaga 720 gcaacgagcg tgtgggctat gatgaatcga aagacgagaa gattgtcaaa atttccatat 780 gaggttcgac aggagatagc gcctcatttt gtggactctg ctcctgtcat tgaagacgat 840 aaaaaattgc acaagcttga tgttaagacg ggtgattcca ttcgcaaggg tctaactcca 900 aggtggaatg acttggatgt caatcagcac gttaacaatg tgaagtacat tgggtggatt 960 ctcaagagtg ttccagcaga agttttcgag acccaggagc tatgcggagt cacccttgag 1020 tacaggcggg aatgtggaag ggacagtgtg ctggagtccg tgaccgctat ggataccgca 1080 aaagagggag accggtctct gtaccagcac cttcttcggc ttgaggatgg ggctgatatc 1140 accataggca gaaccgagtg gcggccgaag aatgcaggag ccaatggggc aatatcaaca 1200 ggaaagactt caaatgaaaa ctctgtctct tag 1233 <210> 42 <211> 1233 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 42 atggtggccg ccgccgcctc ctccgccttc ttctccgtgc ccacccccgg cacctccacc 60 aagcccggca acttcggcaa ctggccctcc tccctgtccg tgcccttcaa gcccgagtcc 120 aaccacaacg gcggcttccg cgtgaaggcc aacgcctccg cccaccccaa ggccaacggc 180 tccgccgtga acctgaagtc cggctccctg gagacccagg aggacacctc ctcctcctcc 240 cccccccccc gcaccttcat caagcagctg cccgactggg gcatgctgct gtccaagatc 300 accaccgtgt tcggcgccgc cgagcgccag tggaagcgcc ccggcatgct ggtggagccc 360 ttcggcgtgg accgcatctt ccaggacggc gtgttcttcc gccagtcctt ctccatccgc 420 tcctacgaga tcggcgccga ccgcaccgcc tccatcgaga ccctgatgaa catcttccag 480 gagacctccc tgaaccactg caagtccatc ggcctgctga acgacggctt cggccgcacc 540 cccgagatgt gcaagcgcga cctgatctgg gtggtgacca agatccaggt ggaggtgaac 600 cgctacccca cctggggcga caccatcgag gtgaacacct gggtgtccga gtccggcaag 660 aacggcatgg gccgcgactg gctgatctcc gactgccgca ccggcgagat cctgatccgc 720 gccacctccg tgtgggccat gatgaaccgc aagacccgcc gcctgtccaa gttcccctac 780 gaggtgcgcc aggagatcgc cccccacttc gtggactccg cccccgtgat cgaggacgac 840 aagaagctgc acaagctgga cgtgaagacc ggcgactcca tccgcaaggg cctgaccccc 900 cgctggaacg acctggacgt gaaccagcac gtgaacaacg tgaagtacat cggctggatc 960 ctgaagtccg tgcccgccga ggtgttcgag acccaggagc tgtgcggcgt gaccctggag 1020 taccgccgcg agtgcggccg cgactccgtg ctggagtccg tgaccgccat ggacaccgcc 1080 aaggagggcg accgctccct gtaccagcac ctgctgcgcc tggaggacgg cgccgacatc 1140 accatcggcc gcaccgagtg gcgccccaag aacgccggcg ccaacggcgc catctccacc 1200 ggcaagacct ccaacgagaa ctccgtgtcc tga 1233 <210> 43 <211> 410 <212> PRT <213> Cuphea heterophylla <400> 43 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Ser 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Asn Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Pro Glu Ser Ser His Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Glu Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Ile Lys Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Lys Ile Thr Thr Val Phe Trp Ala Ala Glu Arg Gln Trp Lys 100 105 110 Arg Pro Gly Met Leu Val Glu Pro Phe Gly Val Asp Arg Ile Phe Gln 115 120 125 Asp Gly Val Phe Phe Arg Gln Ser Phe Ser Ile Arg Ser Tyr Glu Ile 130 135 140 Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Leu Met Asn Ile Phe Gln 145 150 155 160 Glu Thr Ser Leu Asn His Cys Lys Ser Ile Gly Leu Leu Asn Asp Gly 165 170 175 Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu Ile Trp Val Val 180 185 190 Thr Lys Ile Gln Val Glu Val Asn Arg Tyr Pro Thr Trp Gly Asp Thr 195 200 205 Ile Glu Val Asn Thr Trp Val Ser Glu Ser Gly Lys Asn Gly Met Gly 210 215 220 Arg Asp Trp Leu Ile Ser Asp Cys Arg Thr Gly Glu Ile Leu Ile Arg 225 230 235 240 Ala Thr Ser Val Trp Ala Met Met Asn Arg Lys Thr Arg Arg Leu Ser 245 250 255 Lys Phe Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro His Phe Val Asp 260 265 270 Ser Ala Pro Val Ile Glu Asp Asp Lys Lys Leu His Lys Leu Asp Val 275 280 285 Lys Thr Gly Asp Phe Ile Arg Lys Gly Leu Thr Pro Arg Trp Asn Asp 290 295 300 Phe Asp Val Asn Gln His Val Asn Asn Val Lys Tyr Ile Gly Trp Ile 305 310 315 320 Leu Lys Ser Val Pro Ala Glu Val Phe Glu Thr Gln Glu Leu Cys Gly 325 330 335 Val Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg Asp Ser Val Leu Glu 340 345 350 Ser Val Thr Ala Met Asp Thr Ala Lys Glu Gly Asp Arg Ser Leu Tyr 355 360 365 Gln His Leu Leu Arg Leu Glu Asp Gly Ala Asp Ile Thr Ile Gly Arg 370 375 380 Thr Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn Gly Ala Ile Ser Thr 385 390 395 400 Gly Lys Thr Ser Asn Glu Asn Ser Val Ser 405 410 <210> 44 <211> 1233 <212> DNA <213> Cuphea heterophylla <400> 44 atggtggctg ccgcagcaag ttctgcattc ttctccgttc caacctcggg aacctcccct 60 aaacccggga acttcggcaa ttggccatcg agcttgagcg tccccttcaa gcccgaatca 120 agccacaatg gtggctttca ggtcaaggca aacgccagtg cccatcctaa ggctaacggt 180 tctgcagtaa atctaaagtc tggcagcctc gagactcagg aggacacttc atcgtcgtcc 240 cctcctcctc ggacttttat taagcagttg cccgactgga gtatgcttct gtccaaaatc 300 acgactgtct tctgggcggc tgagaggcag tggaagaggc ccggcatgct tgtggaaccg 360 tttggggttg acaggatttt tcaggatggg gtttttttca gacagagttt ttcgatcagg 420 tcttacgaaa taggcgctga tcgaacagcc tcaatagaga cgctgatgaa catcttccag 480 gaaacatctc tgaatcattg taagagtatc ggtcttctca atgacggctt tggtcgtact 540 cctgagatgt gtaagaggga cctcatttgg gtggttacga aaattcaggt cgaggtgaat 600 cgctatccta cttggggtga tactattgag gtcaatactt gggtctcaga gtcggggaaa 660 aacggtatgg gtcgtgattg gctgataagc gattgccgta ccggagaaat tcttataaga 720 gcaacgagcg tgtgggctat gatgaatcga aagacgagaa gattgtcaaa atttccatat 780 gaggttcgac aggagatagc gcctcatttt gtggactctg ctcctgtcat tgaagacgat 840 aaaaaattgc acaagcttga tgttaagacg ggtgatttca ttcgcaaggg tctaactcca 900 aggtggaatg actttgatgt caatcagcac gttaacaatg tgaagtacat tgggtggatt 960 ctcaagagtg ttccagcaga agttttcgag acccaggagc tatgcggagt cacccttgag 1020 tataggcggg aatgtggaag ggacagtgtg ctggagtccg tgaccgctat ggataccgca 1080 aaagagggag accggtctct gtaccagcac cttcttcggc ttgaggatgg ggctgatatc 1140 accataggca gaaccgagtg gcggccgaag aatgcaggag ccaatggggc aatatcaaca 1200 ggaaagactt caaatgaaaa ctctgtctct tag 1233 <210> 45 <211> 1233 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 45 atggtggccg ccgccgcctc ctccgccttc ttctccgtgc ccacctccgg cacctccccc 60 aagcccggca acttcggcaa ctggccctcc tccctgtccg tgcccttcaa gcccgagtcc 120 tcccacaacg gcggcttcca ggtgaaggcc aacgcctccg cccaccccaa ggccaacggc 180 tccgccgtga acctgaagtc cggctccctg gagacccagg aggacacctc ctcctcctcc 240 cccccccccc gcaccttcat caagcagctg cccgactggt ccatgctgct gtccaagatc 300 accaccgtgt tctgggccgc cgagcgccag tggaagcgcc ccggcatgct ggtggagccc 360 ttcggcgtgg accgcatctt ccaggacggc gtgttcttcc gccagtcctt ctccatccgc 420 tcctacgaga tcggcgccga ccgcaccgcc tccatcgaga ccctgatgaa catcttccag 480 gagacctccc tgaaccactg caagtccatc ggcctgctga acgacggctt cggccgcacc 540 cccgagatgt gcaagcgcga cctgatctgg gtggtgacca agatccaggt ggaggtgaac 600 cgctacccca cctggggcga caccatcgag gtgaacacct gggtgtccga gtccggcaag 660 aacggcatgg gccgcgactg gctgatctcc gactgccgca ccggcgagat cctgatccgc 720 gccacctccg tgtgggccat gatgaaccgc aagacccgcc gcctgtccaa gttcccctac 780 gaggtgcgcc aggagatcgc cccccacttc gtggactccg cccccgtgat cgaggacgac 840 aagaagctgc acaagctgga cgtgaagacc ggcgacttca tccgcaaggg cctgaccccc 900 cgctggaacg acttcgacgt gaaccagcac gtgaacaacg tgaagtacat cggctggatc 960 ctgaagtccg tgcccgccga ggtgttcgag acccaggagc tgtgcggcgt gaccctggag 1020 taccgccgcg agtgcggccg cgactccgtg ctggagtccg tgaccgccat ggacaccgcc 1080 aaggagggcg accgctccct gtaccagcac ctgctgcgcc tggaggacgg cgccgacatc 1140 accatcggcc gcaccgagtg gcgccccaag aacgccggcg ccaacggcgc catctccacc 1200 ggcaagacct ccaacgagaa ctccgtgtcc tga 1233 <210> 46 <211> 418 <212> PRT <213> Cuphea heterophylla <400> 46 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Ser Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Thr Trp Leu Ser Ser 20 25 30 Ser Ser Pro Ser Tyr Lys Pro Lys Ser Asn Pro Ser Gly Gly Phe Gln 35 40 45 Val Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Gly Thr Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Arg Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Leu Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Lys Pro Asp Met His Val Asp Trp Phe 115 120 125 Gly Leu Glu Ile Ile Val Gln Asp Gly Leu Val Phe Arg Glu Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn His Leu Gln Asp Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Val Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asn Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ile Trp Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Cys Lys 290 295 300 Gly Leu Thr Pro Glu Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Lys Glu Val 325 330 335 Leu Asp Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Thr Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser 405 410 415 Val Ser <210> 47 <211> 1257 <212> DNA <213> Cuphea heterophylla <400> 47 atggtggtgg ctgctgcagc aagctctgca ttcttccctg ttccggcatc tggaacctcc 60 cctaaacccg ggaagttcgg gacttggcta tcgagctcga gcccttccta caagcccaag 120 tcaaacccca gtggtggatt tcaggttaag gcaaatgcca gtgctcatcc taaggctaac 180 ggttccgcag taagtctaaa gtctggcagc ctcaacactc aggagggcac ttcgtcgtcc 240 cctcctcctc ggactttcct taaccagttg cctgattgga gtaggcttcg gactgcaatc 300 acgaccgtct tcgtggcggc agagaagcag ttgactatgc tcgatcgaaa gtctaagaag 360 cctgacatgc acgtggactg gtttgggttg gagattattg ttcaggatgg gctcgtgttc 420 agagagagtt tttcgatcag gtcttacgaa ataggcgctg atcgaacagc ctctatagaa 480 acgttgatga accatttgca ggacacatct ttgaaccatt gtaagagtgt gggtcttctc 540 aatgacggct ttggtcgtac cccggagatg tgtaaaaggg acctcatttg ggtgcttaca 600 aaaatgcaga tcatggtgaa tcgctatcca acttggggcg atactgtcga gatcaatagc 660 tggttctccc agtccgggaa aatcggtatg ggtcgcaatt ggctaataag tgattgcaac 720 acaggagaaa ttcttataag agcaacgagc atttgggcca tgatgaatca aaagacgaga 780 agattctcaa aacttccaaa cgaggttcgc caggagatag cgcctcattt tgtggacgcc 840 cctcctgtca ttgaagacaa tgatcgaaaa ttgcataagt ttgatgtgaa gactggtgat 900 tccatttgca agggtctaac accggagtgg aatgacttgg atgtcaatca gcacgtaagc 960 aacgtgaagt acattgggtg gattctcgag agtatgccaa aagaagtttt ggacacccag 1020 gagctatgct ctctcaccct tgaatatagg cgggaatgcg gaagggatag tgtgctggag 1080 tctgtgaccg ctatggatcc ctcaaaagtt ggagaccgat ctcagtacca gcaccttctg 1140 cggcttgaag atgggactga tatcatgaag ggcagaactg agtggcgacc aaagaatgca 1200 ggaaccaacg gggctatatc aacaggaaag acttcaaatg gaaactcggt ctcttag 1257 <210> 48 <211> 1257 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 48 atggtggtgg ccgccgccgc ctcctccgcc ttcttccccg tgcccgcctc cggcacctcc 60 cccaagcccg gcaagttcgg cacctggctg tcctcctcct ccccctccta caagcccaag 120 tccaacccct ccggcggctt ccaggtgaag gccaacgcct ccgcccaccc caaggccaac 180 ggctccgccg tgtccctgaa gtccggctcc ctgaacaccc aggagggcac ctcctcctcc 240 cccccccccc gcaccttcct gaaccagctg cccgactggt cccgcctgcg caccgccatc 300 accaccgtgt tcgtggccgc cgagaagcag ctgaccatgc tggaccgcaa gtccaagaag 360 cccgacatgc acgtggactg gttcggcctg gagatcatcg tgcaggacgg cctggtgttc 420 cgcgagtcct tctccatccg ctcctacgag atcggcgccg accgcaccgc ctccatcgag 480 accctgatga accacctgca ggacacctcc ctgaaccact gcaagtccgt gggcctgctg 540 aacgacggct tcggccgcac ccccgagatg tgcaagcgcg acctgatctg ggtgctgacc 600 aagatgcaga tcatggtgaa ccgctacccc acctggggcg acaccgtgga gatcaactcc 660 tggttctccc agtccggcaa gatcggcatg ggccgcaact ggctgatctc cgactgcaac 720 accggcgaga tcctgatccg cgccacctcc atctgggcca tgatgaacca gaagacccgc 780 cgcttctcca agctgcccaa cgaggtgcgc caggagatcg ccccccactt cgtggacgcc 840 ccccccgtga tcgaggacaa cgaccgcaag ctgcacaagt tcgacgtgaa gaccggcgac 900 tccatctgca agggcctgac ccccgagtgg aacgacctgg acgtgaacca gcacgtgtcc 960 aacgtgaagt acatcggctg gatcctggag tccatgccca aggaggtgct ggacacccag 1020 gagctgtgct ccctgaccct ggagtaccgc cgcgagtgcg gccgcgactc cgtgctggag 1080 tccgtgaccg ccatggaccc ctccaaggtg ggcgaccgct cccagtacca gcacctgctg 1140 cgcctggagg acggcaccga catcatgaag ggccgcaccg agtggcgccc caagaacgcc 1200 ggcaccaacg gcgccatctc caccggcaag acctccaacg gcaactccgt gtcctga 1257 <210> 49 <211> 418 <212> PRT <213> Cuphea heterophylla <400> 49 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Pro Gly Thr Thr Ser Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser 20 25 30 Leu Ser Pro Ser Phe Lys Pro Lys Ser Asn Pro Asn Gly Gly Phe Gln 35 40 45 Val Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Lys Glu Asp Thr Pro Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Arg Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Leu Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Lys Pro Asp Met His Val Asp Trp Phe 115 120 125 Gly Leu Glu Ile Ile Val Gln Asp Trp Leu Val Phe Arg Glu Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn His Leu Gln Asp Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Val Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asn Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ile Trp Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Leu Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Cys Lys 290 295 300 Gly Leu Thr Pro Glu Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Lys Glu Val 325 330 335 Leu Asp Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Thr Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser 405 410 415 Val Ser <210> 50 <211> 1257 <212> DNA <213> Cuphea heterophylla <400> 50 atggtggtgg ctgctgcagc aagttctgca ttcttccctg ttccagcacc tggaaccacg 60 tctaaacccg ggaagttcgg caattggcca tcgagcttga gcccttcctt caagcccaag 120 tcaaacccca atggtggatt tcaggttaag gcaaatgcca gcgctcatcc taaggctaac 180 gggtctgcag taagtctaaa gtctggcagc ctcaacacta aggaggacac tccgtcgtcc 240 cctcctcctc ggactttcct taaccagttg cctgattgga gtaggcttcg gactgcaatc 300 acgaccgtct tcgtggcggc agagaagcag ttgactatgc tcgatcgaaa gtctaagaag 360 cctgacatgc acgtggactg gtttgggttg gagattattg ttcaggattg gctcgtgttc 420 agagagagtt tttcgatcag gtcttacgaa ataggcgctg atcgaacagc ctctatagaa 480 acgttgatga accatttgca ggacacatct ttgaaccatt gtaagagtgt gggtcttctc 540 aatgacggct ttggtcgtac cccggagatg tgtaaaaggg acctcatttg ggtgcttaca 600 aaaatgcaga tcatggtgaa tcgctatcca acttggggcg atactgtcga gatcaatagc 660 tggttctccc agtccgggaa aatcggtatg ggtcgcaatt ggctaataag tgattgcaac 720 acaggagaaa ttcttataag agcaacgagc atttgggcca tgatgaatca aaagacgaga 780 agattctcaa aacttccaaa cgaggttcgc caggagatag ctcctcattt tgtggacgcc 840 cctcctctca ttgaagacaa tgatcgaaaa ttgcataagt ttgatgtgaa gactggtgat 900 tccatttgca agggtctaac accggagtgg aatgacttgg atgtcaatca gcacgtaagc 960 aacgtgaagt acattgggtg gattctcgag agtatgccaa aagaagtttt ggacacccag 1020 gagctatgct ctctcaccct tgaatatagg cgggaatgcg gaagggacag tgtgctggag 1080 tctgtgaccg ctatggatcc ctcaaaagtt ggagaccgat ctcagtacca gcaccttctg 1140 cggcttgaag atgggactga tatcatgaag ggcagaactg agtggcgacc aaagaatgca 1200 ggaaccaacg gggcgatatc aacaggaaag acttcaaatg gaaactcggt ctcttag 1257 <210> 51 <211> 1257 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 51 atggtggtgg ccgccgccgc ctcctccgcc ttcttccccg tgcccgcccc cggcaccacc 60 tccaagcccg gcaagttcgg caactggccc tcctccctgt ccccctcctt caagcccaag 120 tccaacccca acggcggctt ccaggtgaag gccaacgcct ccgcccaccc caaggccaac 180 ggctccgccg tgtccctgaa gtccggctcc ctgaacacca aggaggacac cccctcctcc 240 cccccccccc gcaccttcct gaaccagctg cccgactggt cccgcctgcg caccgccatc 300 accaccgtgt tcgtggccgc cgagaagcag ctgaccatgc tggaccgcaa gtccaagaag 360 cccgacatgc acgtggactg gttcggcctg gagatcatcg tgcaggactg gctggtgttc 420 cgcgagtcct tctccatccg ctcctacgag atcggcgccg accgcaccgc ctccatcgag 480 accctgatga accacctgca ggacacctcc ctgaaccact gcaagtccgt gggcctgctg 540 aacgacggct tcggccgcac ccccgagatg tgcaagcgcg acctgatctg ggtgctgacc 600 aagatgcaga tcatggtgaa ccgctacccc acctggggcg acaccgtgga gatcaactcc 660 tggttctccc agtccggcaa gatcggcatg ggccgcaact ggctgatctc cgactgcaac 720 accggcgaga tcctgatccg cgccacctcc atctgggcca tgatgaacca gaagacccgc 780 cgcttctcca agctgcccaa cgaggtgcgc caggagatcg ccccccactt cgtggacgcc 840 ccccccctga tcgaggacaa cgaccgcaag ctgcacaagt tcgacgtgaa gaccggcgac 900 tccatctgca agggcctgac ccccgagtgg aacgacctgg acgtgaacca gcacgtgtcc 960 aacgtgaagt acatcggctg gatcctggag tccatgccca aggaggtgct ggacacccag 1020 gagctgtgct ccctgaccct ggagtaccgc cgcgagtgcg gccgcgactc cgtgctggag 1080 tccgtgaccg ccatggaccc ctccaaggtg ggcgaccgct cccagtacca gcacctgctg 1140 cgcctggagg acggcaccga catcatgaag ggccgcaccg agtggcgccc caagaacgcc 1200 ggcaccaacg gcgccatctc caccggcaag acctccaacg gcaactccgt gtcctga 1257 <210> 52 <211> 418 <212> PRT <213> Cuphea heterophylla <400> 52 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Ser Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Thr Trp Leu Ser Ser 20 25 30 Ser Ser Pro Ser Tyr Lys Pro Lys Ser Asn Pro Ser Gly Gly Phe Gln 35 40 45 Val Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Lys Glu Asp Thr Pro Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Asn Arg Leu 85 90 95 Arg Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Leu Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Lys Pro Asp Met His Val Asp Trp Phe 115 120 125 Gly Leu Glu Ile Ile Val Gln Asp Gly Leu Val Phe Arg Glu Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn His Leu Gln Asp Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Val Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asn Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ile Trp Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Cys Lys 290 295 300 Gly Leu Thr Pro Glu Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Lys Glu Val 325 330 335 Leu Asp Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Thr Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser 405 410 415 Val Ser <210> 53 <211> 1257 <212> DNA <213> Cuphea heterophylla <400> 53 atggtggtgg ctgctgcagc aagctctgca ttcttccctg ttccggcatc tggaacctcc 60 cctaaacccg ggaagttcgg gacttggcta tcgagctcga gcccttccta caagcccaag 120 tcaaacccca gtggtggatt tcaggttaag gcaaatgcca gtgctcatcc taaggctaac 180 ggttccgcag taagtctaaa gtctggcagc ctcaacacta aggaggacac tccgtcgtcc 240 cctcctcctc ggactttcct taaccagttg cctgattgga ataggcttcg gactgcaatc 300 acgaccgtct tcgtggcggc agagaagcag ttgactatgc tcgatcgaaa gtctaagaag 360 cctgacatgc acgtggactg gtttgggttg gagattattg ttcaggatgg gctcgtgttc 420 agagagagtt tttcgatcag gtcttacgaa ataggcgctg atcgaacagc ctctatagaa 480 acgttgatga accatttgca ggacacatct ttgaaccatt gtaagagtgt gggtcttctc 540 aatgacggct ttggtcgtac cccggagatg tgtaaaaggg acctcatttg ggtgcttaca 600 aaaatgcaga tcatggtgaa tcgctatcca acttggggcg atactgtcga gatcaatagc 660 tggttctccc agtccgggaa aatcggtatg ggtcgcaatt ggctaataag tgattgcaac 720 acaggagaaa ttcttataag agcaacgagc atttgggcca tgatgaatca aaagacgaga 780 agattctcaa aacttccaaa cgaggttcgc caggagatag cgcctcattt tgtggacgcc 840 cctcctgtca ttgaagacaa tgatcgaaaa ttgcataagt ttgatgtgaa gactggtgat 900 tccatttgca agggtctaac accggagtgg aatgacttgg atgtcaatca gcacgtaagc 960 aacgtgaagt acattgggtg gattctcgag agtatgccaa aagaagtttt ggacacccag 1020 gagctatgct ctctcaccct tgaatatagg cgggaatgcg gaagggacag tgtgctggag 1080 tctgtgaccg ctatggatcc ctcaaaagtt ggggaccgat ctcagtacca gcaccttctg 1140 cggcttgaag atgggactga tatcatgaag ggcagaactg agtggcgacc aaagaatgca 1200 ggaaccaacg gggctatatc aacaggaaag acttcaaatg gaaactcggt ctcttag 1257 <210> 54 <211> 1257 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 54 atggtggtgg ccgccgccgc ctcctccgcc ttcttccccg tgcccgcctc cggcacctcc 60 cccaagcccg gcaagttcgg cacctggctg tcctcctcct ccccctccta caagcccaag 120 tccaacccct ccggcggctt ccaggtgaag gccaacgcct ccgcccaccc caaggccaac 180 ggctccgccg tgtccctgaa gtccggctcc ctgaacacca aggaggacac cccctcctcc 240 cccccccccc gcaccttcct gaaccagctg cccgactgga accgcctgcg caccgccatc 300 accaccgtgt tcgtggccgc cgagaagcag ctgaccatgc tggaccgcaa gtccaagaag 360 cccgacatgc acgtggactg gttcggcctg gagatcatcg tgcaggacgg cctggtgttc 420 cgcgagtcct tctccatccg ctcctacgag atcggcgccg accgcaccgc ctccatcgag 480 accctgatga accacctgca ggacacctcc ctgaaccact gcaagtccgt gggcctgctg 540 aacgacggct tcggccgcac ccccgagatg tgcaagcgcg acctgatctg ggtgctgacc 600 aagatgcaga tcatggtgaa ccgctacccc acctggggcg acaccgtgga gatcaactcc 660 tggttctccc agtccggcaa gatcggcatg ggccgcaact ggctgatctc cgactgcaac 720 accggcgaga tcctgatccg cgccacctcc atctgggcca tgatgaacca gaagacccgc 780 cgcttctcca agctgcccaa cgaggtgcgc caggagatcg ccccccactt cgtggacgcc 840 ccccccgtga tcgaggacaa cgaccgcaag ctgcacaagt tcgacgtgaa gaccggcgac 900 tccatctgca agggcctgac ccccgagtgg aacgacctgg acgtgaacca gcacgtgtcc 960 aacgtgaagt acatcggctg gatcctggag tccatgccca aggaggtgct ggacacccag 1020 gagctgtgct ccctgaccct ggagtaccgc cgcgagtgcg gccgcgactc cgtgctggag 1080 tccgtgaccg ccatggaccc ctccaaggtg ggcgaccgct cccagtacca gcacctgctg 1140 cgcctggagg acggcaccga catcatgaag ggccgcaccg agtggcgccc caagaacgcc 1200 ggcaccaacg gcgccatctc caccggcaag acctccaacg gcaactccgt gtcctga 1257 <210> 55 <211> 418 <212> PRT <213> Cuphea heterophylla <400> 55 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Pro Gly Thr Thr Ser Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser 20 25 30 Leu Ser Pro Ser Phe Lys Pro Lys Ser Asn Pro Asn Gly Gly Phe Gln 35 40 45 Val Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Leu Thr Ala Ile Ser Thr Val Phe Val Ala Ala Glu Lys Gln Leu Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Leu Phe 115 120 125 Gly Leu Glu Ser Ile Val Gln Asp Gly Leu Val Phe Arg Glu Ser Tyr 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn His Leu Gln Asp Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Val Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asn Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ile Trp Ala Met Met Asn 245 250 255 Gln Asn Thr Arg Arg Phe Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys 290 295 300 Gly Leu Thr Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val 325 330 335 Leu Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Glu Ser Val Leu Glu Ser Val Thr Ala Met Asn Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Ala Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser 405 410 415 Val Ser <210> 56 <211> 1257 <212> DNA <213> Cuphea heterophylla <400> 56 atggtggtgg ctgctgcagc aagttctgca ttcttccctg ttccagcacc tggaaccacg 60 tctaaacccg ggaagttcgg caattggcca tcgagcttga gcccttcctt caagcccaag 120 tcaaacccca atggtggatt tcaggttaag gcaaatgcca gtgctcatcc taaggctaac 180 ggttctgcgg taagtctaaa gtctggcagc ctcaacactc aggaggacac ttcgtcgtcc 240 cctcctcctc ggacattcct taaccagttg cctgattgga gtaggcttct gactgcaatc 300 tcgaccgtct tcgtggcggc agagaagcag ttgactatgc tcgatcgaaa atctaagagg 360 cctgacatgc tcgtggactt gtttgggttg gagagtattg ttcaggatgg gctcgtgttc 420 agagagagtt attcgatcag gtcttacgaa ataggcgctg atcgaacagc ctctatagaa 480 acgttgatga accatttgca ggacacatct ttgaaccatt gtaagagtgt gggtcttctc 540 aatgacggct ttggtcgtac cccggagatg tgtaaaaggg acctcatttg ggtgcttaca 600 aaaatgcaga tcatggtgaa tcgctatcca acttggggcg atactgtcga gatcaatagc 660 tggttctccc agtccgggaa aatcggtatg ggtcgcaatt ggctaataag tgattgcaac 720 acaggagaaa ttcttataag agcaacgagc atttgggcca tgatgaatca aaatacgaga 780 agattctcaa aacttccaaa cgaggttcgc caggagatag cgcctcattt tgttgacgct 840 cctcctgtca ttgaagacaa tgatcgaaaa ttgcataagt ttgatgtgaa gactggtgat 900 tccattcgca agggtctaac tccggggtgg aatgacttgg atgtcaatca gcacgtaagc 960 aacgtgaagt acattgggtg gattctcgag agtatgccaa cagaagtttt ggagacccag 1020 gagctatgct ctctcaccct tgaatatagg cgggaatgcg gaagggaaag tgtgctggag 1080 tccgtgaccg ctatgaatcc ctcaaaagtt ggagaccggt ctcagtacca gcaccttcta 1140 cggcttgagg atggggctga tatcatgaag ggcagaactg agtggcgacc aaagaatgca 1200 ggaaccaacg gggcgatatc aacaggaaag acttcaaatg gaaactcggt ctcttag 1257 <210> 57 <211> 1257 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 57 atggtggtgg ccgccgccgc ctcctccgcc ttcttccccg tgcccgcccc cggcaccacc 60 tccaagcccg gcaagttcgg caactggccc tcctccctgt ccccctcctt caagcccaag 120 tccaacccca acggcggctt ccaggtgaag gccaacgcct ccgcccaccc caaggccaac 180 ggctccgccg tgtccctgaa gtccggctcc ctgaacaccc aggaggacac ctcctcctcc 240 cccccccccc gcaccttcct gaaccagctg cccgactggt cccgcctgct gaccgccatc 300 tccaccgtgt tcgtggccgc cgagaagcag ctgaccatgc tggaccgcaa gtccaagcgc 360 cccgacatgc tggtggacct gttcggcctg gagtccatcg tgcaggacgg cctggtgttc 420 cgcgagtcct actccatccg ctcctacgag atcggcgccg accgcaccgc ctccatcgag 480 accctgatga accacctgca ggacacctcc ctgaaccact gcaagtccgt gggcctgctg 540 aacgacggct tcggccgcac ccccgagatg tgcaagcgcg acctgatctg ggtgctgacc 600 aagatgcaga tcatggtgaa ccgctacccc acctggggcg acaccgtgga gatcaactcc 660 tggttctccc agtccggcaa gatcggcatg ggccgcaact ggctgatctc cgactgcaac 720 accggcgaga tcctgatccg cgccacctcc atctgggcca tgatgaacca gaacacccgc 780 cgcttctcca agctgcccaa cgaggtgcgc caggagatcg ccccccactt cgtggacgcc 840 ccccccgtga tcgaggacaa cgaccgcaag ctgcacaagt tcgacgtgaa gaccggcgac 900 tccatccgca agggcctgac ccccggctgg aacgacctgg acgtgaacca gcacgtgtcc 960 aacgtgaagt acatcggctg gatcctggag tccatgccca ccgaggtgct ggagacccag 1020 gagctgtgct ccctgaccct ggagtaccgc cgcgagtgcg gccgcgagtc cgtgctggag 1080 tccgtgaccg ccatgaaccc ctccaaggtg ggcgaccgct cccagtacca gcacctgctg 1140 cgcctggagg acggcgccga catcatgaag ggccgcaccg agtggcgccc caagaacgcc 1200 ggcaccaacg gcgccatctc caccggcaag acctccaacg gcaactccgt gtcctga 1257 <210> 58 <211> 418 <212> PRT <213> Cuphea heterophylla <400> 58 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Ser Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Thr Trp Leu Ser Ser 20 25 30 Ser Ser Pro Ser Tyr Lys Pro Lys Ser Asn Pro Ser Gly Gly Phe Gln 35 40 45 Val Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser 65 70 75 80 Pro Pro Pro Gln Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Leu Thr Ala Ile Ser Thr Val Phe Val Ala Ala Glu Lys Gln Leu Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Trp Phe 115 120 125 Gly Leu Glu Ser Ile Val Gln Asp Gly Leu Val Phe Arg Glu Ser Tyr 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Ser Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Val Met Asn Leu Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Met Gly Ile Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Leu Val Asn Arg 195 200 205 Tyr Pro Asn Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asn Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ile Trp Ala Met Met Asn 245 250 255 Gln Asn Thr Arg Arg Phe Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys 290 295 300 Gly Leu Thr Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val 325 330 335 Leu Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asn Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Ala Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser 405 410 415 Val Ser <210> 59 <211> 1257 <212> DNA <213> Cuphea heterophylla <400> 59 atggtggtgg ctgctgcagc aagctctgca ttcttccctg ttccggcatc tggaacctcc 60 cctaaacccg ggaagttcgg gacttggcta tcgagctcga gcccttccta caagcccaag 120 tcaaacccca gtggtggatt tcaggttaag gcaaatgcca gtgctcatcc taaggctaac 180 ggttctgcag taagtctaaa gtctggcagc ctcaacactc aggaggacac ttcgtcgtcc 240 cctcctcctc agacattcct taaccagttg cctgattgga gtaggcttct gacagcaatc 300 tcgaccgtct tcgtggcggc agagaagcag ttgactatgc tcgatcgaaa atctaaaagg 360 cctgacatgc tcgtggactg gtttgggttg gagagtattg ttcaggatgg gctcgtgttc 420 agagagagtt attcgatcag gtcttacgaa ataagcgctg atcgaacagc ctctatagag 480 acggtgatga acctcttgca ggaaacatct ctcaatcatt gtaagagtat gggtattctc 540 aatgacggct ttggtcgtac cccggagatg tgcaaaaggg acctcatttg ggtgcttaca 600 aaaatgcaga tcttggtgaa tcgctatcca aattggggtg atactgtcga gatcaatagc 660 tggttctccc agtccgggaa aatcggtatg ggtcgcaatt ggctaataag tgattgcaac 720 acaggagaaa ttcttataag agcaacgagc atttgggcca tgatgaatca aaatacgaga 780 agattctcaa aacttccaaa cgaggttcgc caggagatag cgcctcattt tgttgacgct 840 cctcctgtca ttgaagacaa tgatcgaaaa ttgcataagt ttgatgtgaa gactggtgat 900 tccattcgca agggtctaac tccggggtgg aatgacttgg atgtcaatca gcacgtaagc 960 aacgtgaagt acattgggtg gattctcgag agtatgccaa cagaagtttt ggagacccag 1020 gagctatgct ctctcaccct tgaatatagg cgggaatgcg gaagggacag tgtgctggag 1080 tccgtgaccg ctatgaatcc ctcaaaagtt ggagaccggt ctcagtacca gcaccttcta 1140 cggcttgagg atggggctga tatcatgaag ggcagaactg agtggcgacc aaagaatgca 1200 ggaaccaacg gggcgatatc aacaggaaag acttcaaatg gaaactcggt ctcttag 1257 <210> 60 <211> 1257 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 60 atggtggtgg ccgccgccgc ctcctccgcc ttcttccccg tgcccgcctc cggcacctcc 60 cccaagcccg gcaagttcgg cacctggctg tcctcctcct ccccctccta caagcccaag 120 tccaacccct ccggcggctt ccaggtgaag gccaacgcct ccgcccaccc caaggccaac 180 ggctccgccg tgtccctgaa gtccggctcc ctgaacaccc aggaggacac ctcctcctcc 240 cccccccccc agaccttcct gaaccagctg cccgactggt cccgcctgct gaccgccatc 300 tccaccgtgt tcgtggccgc cgagaagcag ctgaccatgc tggaccgcaa gtccaagcgc 360 cccgacatgc tggtggactg gttcggcctg gagtccatcg tgcaggacgg cctggtgttc 420 cgcgagtcct actccatccg ctcctacgag atctccgccg accgcaccgc ctccatcgag 480 accgtgatga acctgctgca ggagacctcc ctgaaccact gcaagtccat gggcatcctg 540 aacgacggct tcggccgcac ccccgagatg tgcaagcgcg acctgatctg ggtgctgacc 600 aagatgcaga tcctggtgaa ccgctacccc aactggggcg acaccgtgga gatcaactcc 660 tggttctccc agtccggcaa gatcggcatg ggccgcaact ggctgatctc cgactgcaac 720 accggcgaga tcctgatccg cgccacctcc atctgggcca tgatgaacca gaacacccgc 780 cgcttctcca agctgcccaa cgaggtgcgc caggagatcg ccccccactt cgtggacgcc 840 ccccccgtga tcgaggacaa cgaccgcaag ctgcacaagt tcgacgtgaa gaccggcgac 900 tccatccgca agggcctgac ccccggctgg aacgacctgg acgtgaacca gcacgtgtcc 960 aacgtgaagt acatcggctg gatcctggag tccatgccca ccgaggtgct ggagacccag 1020 gagctgtgct ccctgaccct ggagtaccgc cgcgagtgcg gccgcgactc cgtgctggag 1080 tccgtgaccg ccatgaaccc ctccaaggtg ggcgaccgct cccagtacca gcacctgctg 1140 cgcctggagg acggcgccga catcatgaag ggccgcaccg agtggcgccc caagaacgcc 1200 ggcaccaacg gcgccatctc caccggcaag acctccaacg gcaactccgt gtcctga 1257 <210> 61 <211> 418 <212> PRT <213> Cuphea heterophylla <400> 61 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Ser Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Thr Trp Leu Ser Ser 20 25 30 Ser Ser Pro Ser Tyr Lys Pro Lys Ser Asn Pro Ser Gly Gly Phe Gln 35 40 45 Val Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Gly Thr Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Leu Thr Ala Ile Ser Thr Val Phe Val Ala Ala Glu Lys Gln Leu Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Trp Phe 115 120 125 Gly Leu Glu Ser Ile Val Gln Asp Gly Leu Val Phe Arg Glu Ser Tyr 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Ser Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Val Met Asn Leu Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Met Gly Ile Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Leu Val Asn Arg 195 200 205 Tyr Pro Asn Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asn Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ile Trp Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Cys Lys 290 295 300 Gly Leu Thr Pro Glu Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Lys Glu Val 325 330 335 Leu Asp Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Thr Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser 405 410 415 Val Ser <210> 62 <211> 1257 <212> DNA <213> Cuphea heterophylla <400> 62 atggtggtgg ctgctgcagc aagctctgca ttcttccctg ttccggcatc tggaacctcc 60 cctaaacccg ggaagttcgg gacttggcta tcgagctcga gcccttccta caagcccaag 120 tcaaacccca gtggtggatt tcaggttaaa gcaaatgcca gtgctcatcc taaggctaac 180 ggttccgcag taagtctaaa gtctggcagc ctcaacactc aggagggcac ttcgtcgtcc 240 cctcctcctc ggacattcct taaccagttg cctgattgga gtaggcttct gactgcaatc 300 tcgaccgtct tcgtggcggc agagaagcag ttgactatgc tcgatcgaaa atctaagagg 360 cctgacatgc tcgtggactg gtttgggttg gagagtattg ttcaggatgg gctcgtgttc 420 agagagagtt attcgatcag gtcttacgaa ataagcgctg atcgaacagc ctctatagag 480 acggtgatga acctcttgca ggaaacatct ctcaatcatt gtaagagtat gggtattctc 540 aatgacggct ttggtcgtac cccggagatg tgcaaaaggg acctcatttg ggtgcttaca 600 aaaatgcaga tcttggtgaa tcgctatcca aattggggtg atactgtcga gatcaatagc 660 tggttctccc agtccgggaa aatcggtatg ggtcgcaatt ggctaataag tgattgcaac 720 acaggagaaa ttcttataag agcaacgagc atttgggcca tgatgaatca aaagacgaga 780 agattctcaa aacttccaaa tgaggttcgc caggagatag cgcctcattt tgtggacgcc 840 cctcctgtca ttgaagacaa tgatcgaaaa ttgcataagt ttgatgtgaa gactggtgat 900 tccatttgca agggtctaac accggagtgg aacgacttgg atgtcaatca gcacgtaagc 960 aacgtgaagt acattgggtg gattctcgag agtatgccaa aagaagtttt ggacacccag 1020 gagctatgct ctctcaccct tgaatatagg cgggaatgcg gaagggacag tgtgctggag 1080 tctgtgaccg ctatggatcc ctcaaaagtt ggagaccgat ctcagtacca gcaccttctg 1140 cggcttgaag atgggactga tatcatgaag ggcagaactg agtggcgacc aaagaatgca 1200 ggaaccaacg gggcgatatc aacaggaaag acttcaaatg gaaactcggt ctcttag 1257 <210> 63 <211> 1257 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 63 atggtggtgg ccgccgccgc ctcctccgcc ttcttccccg tgcccgcctc cggcacctcc 60 cccaagcccg gcaagttcgg cacctggctg tcctcctcct ccccctccta caagcccaag 120 tccaacccct ccggcggctt ccaggtgaag gccaacgcct ccgcccaccc caaggccaac 180 ggctccgccg tgtccctgaa gtccggctcc ctgaacaccc aggagggcac ctcctcctcc 240 cccccccccc gcaccttcct gaaccagctg cccgactggt cccgcctgct gaccgccatc 300 tccaccgtgt tcgtggccgc cgagaagcag ctgaccatgc tggaccgcaa gtccaagcgc 360 cccgacatgc tggtggactg gttcggcctg gagtccatcg tgcaggacgg cctggtgttc 420 cgcgagtcct actccatccg ctcctacgag atctccgccg accgcaccgc ctccatcgag 480 accgtgatga acctgctgca ggagacctcc ctgaaccact gcaagtccat gggcatcctg 540 aacgacggct tcggccgcac ccccgagatg tgcaagcgcg acctgatctg ggtgctgacc 600 aagatgcaga tcctggtgaa ccgctacccc aactggggcg acaccgtgga gatcaactcc 660 tggttctccc agtccggcaa gatcggcatg ggccgcaact ggctgatctc cgactgcaac 720 accggcgaga tcctgatccg cgccacctcc atctgggcca tgatgaacca gaagacccgc 780 cgcttctcca agctgcccaa cgaggtgcgc caggagatcg ccccccactt cgtggacgcc 840 ccccccgtga tcgaggacaa cgaccgcaag ctgcacaagt tcgacgtgaa gaccggcgac 900 tccatctgca agggcctgac ccccgagtgg aacgacctgg acgtgaacca gcacgtgtcc 960 aacgtgaagt acatcggctg gatcctggag tccatgccca aggaggtgct ggacacccag 1020 gagctgtgct ccctgaccct ggagtaccgc cgcgagtgcg gccgcgactc cgtgctggag 1080 tccgtgaccg ccatggaccc ctccaaggtg ggcgaccgct cccagtacca gcacctgctg 1140 cgcctggagg acggcaccga catcatgaag ggccgcaccg agtggcgccc caagaacgcc 1200 ggcaccaacg gcgccatctc caccggcaag acctccaacg gcaactccgt gtcctga 1257 <210> 64 <211> 418 <212> PRT <213> Cuphea heterophylla <400> 64 Met Val Val Ala Ala Thr Ala Ser Ser Ala Phe Phe Pro Val Pro Val 1 5 10 15 Pro Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Thr Trp Leu Ser Ser 20 25 30 Ser Ser Pro Ser Tyr Lys Pro Lys Ser Asn Pro Ser Gly Gly Phe Gln 35 40 45 Val Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Leu Thr Ala Ile Ser Thr Val Phe Val Ala Ala Glu Lys Gln Leu Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Trp Phe 115 120 125 Gly Leu Glu Ser Ile Val Gln Asp Gly Leu Val Phe Arg Glu Ile Tyr 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Ser Ala Asp Arg Thr Thr Ser Ile Glu 145 150 155 160 Thr Val Met Asn Leu Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Met Gly Ile Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Leu Val Asn Arg 195 200 205 Tyr Pro Asn Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asn Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ile Trp Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Cys Lys 290 295 300 Gly Leu Thr Pro Glu Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Lys Glu Val 325 330 335 Leu Asp Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Thr Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Ala Asn Ser 405 410 415 Val Ser <210> 65 <211> 1257 <212> DNA <213> Cuphea heterophylla <400> 65 atggtggtgg ctgctacagc aagttctgca ttcttccctg ttcctgtacc tggaacctcc 60 cctaaacccg gaaagttcgg gacttggcta tcgagctcga gcccttccta caagcccaag 120 tcaaacccca gtggtggatt tcaggttaag gcaaatgcca gtgctcatcc taaggctaac 180 ggttctgcag taagtctaaa gtctggcagc ctcaacactc aggaggacac ttcgtcgtcc 240 cctcctcctc ggacattcct taaccagttg cctgattgga gtaggcttct gactgcaatc 300 tcgaccgtct tcgtggcggc agagaagcag ttgactatgc tcgatcgaaa atctaagagg 360 cctgacatgc tcgtggactg gtttgggttg gagagtattg ttcaggatgg gctcgtgttc 420 agagagattt attcgatcag gtcttacgaa ataagcgctg atcgaacaac ctctatagag 480 acggtgatga acctcttgca ggaaacatct ctcaatcatt gtaagagtat gggtattctc 540 aatgacggct ttggtcgtac cccggagatg tgcaaaaggg acctcatttg ggtgcttaca 600 aaaatgcaga tcttggtgaa tcgctatcca aattggggtg atactgtcga gatcaatagc 660 tggttctccc agtccgggaa aatcggtatg ggtcgcaatt ggctaataag tgattgcaac 720 acaggagaaa ttcttataag agcaacgagc atttgggcca tgatgaatca aaagacgaga 780 agattctcaa aacttccaaa cgaggttcgc caggagatag cgcctcattt tgtggacgcc 840 cctcctgtca ttgaagacaa tgatcgaaaa ttgcataagt ttgatgtgaa gactggtgat 900 tccatttgca agggtctaac accggagtgg aatgacttgg atgtcaatca gcacgtaagc 960 aacgtgaagt acattgggtg gattctcgag agtatgccaa aagaagtttt ggacacccag 1020 gagctatgct ctctcaccct tgaatatagg cgggaatgcg gaagggacag tgtgctggag 1080 tctgtgaccg ctatggatcc ctcaaaagtt ggagaccgat ctcagtacca gcaccttctg 1140 cggcttgaag atgggactga tatcatgaag ggcagaactg agtggcgacc aaagaatgca 1200 ggaaccaacg gggcgatatc aacaggaaag acttcaaatg caaactcggt ctcttag 1257 <210> 66 <211> 1257 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 66 atggtggtgg ccgccaccgc ctcctccgcc ttcttccccg tgcccgtgcc cggcacctcc 60 cccaagcccg gcaagttcgg cacctggctg tcctcctcct ccccctccta caagcccaag 120 tccaacccct ccggcggctt ccaggtgaag gccaacgcct ccgcccaccc caaggccaac 180 ggctccgccg tgtccctgaa gtccggctcc ctgaacaccc aggaggacac ctcctcctcc 240 cccccccccc gcaccttcct gaaccagctg cccgactggt cccgcctgct gaccgccatc 300 tccaccgtgt tcgtggccgc cgagaagcag ctgaccatgc tggaccgcaa gtccaagcgc 360 cccgacatgc tggtggactg gttcggcctg gagtccatcg tgcaggacgg cctggtgttc 420 cgcgagatct actccatccg ctcctacgag atctccgccg accgcaccac ctccatcgag 480 accgtgatga acctgctgca ggagacctcc ctgaaccact gcaagtccat gggcatcctg 540 aacgacggct tcggccgcac ccccgagatg tgcaagcgcg acctgatctg ggtgctgacc 600 aagatgcaga tcctggtgaa ccgctacccc aactggggcg acaccgtgga gatcaactcc 660 tggttctccc agtccggcaa gatcggcatg ggccgcaact ggctgatctc cgactgcaac 720 accggcgaga tcctgatccg cgccacctcc atctgggcca tgatgaacca gaagacccgc 780 cgcttctcca agctgcccaa cgaggtgcgc caggagatcg ccccccactt cgtggacgcc 840 ccccccgtga tcgaggacaa cgaccgcaag ctgcacaagt tcgacgtgaa gaccggcgac 900 tccatctgca agggcctgac ccccgagtgg aacgacctgg acgtgaacca gcacgtgtcc 960 aacgtgaagt acatcggctg gatcctggag tccatgccca aggaggtgct ggacacccag 1020 gagctgtgct ccctgaccct ggagtaccgc cgcgagtgcg gccgcgactc cgtgctggag 1080 tccgtgaccg ccatggaccc ctccaaggtg ggcgaccgct cccagtacca gcacctgctg 1140 cgcctggagg acggcaccga catcatgaag ggccgcaccg agtggcgccc caagaacgcc 1200 ggcaccaacg gcgccatctc caccggcaag acctccaacg ccaactccgt gtcctga 1257 <210> 67 <211> 414 <212> PRT <213> Cuphea heterophylla <400> 67 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Thr Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Arg Pro Leu Lys Pro Lys Phe Val Ala Asn Ala Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Ser Leu 50 55 60 Lys Ser Cys Ser Leu Lys Thr His Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Glu Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Lys Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Trp Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys 355 360 365 Gly Phe Gly Pro Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile 385 390 395 400 Asn Gly Thr Ile Ala Ser Gly Glu Thr Ser Pro Gly Asn Ser 405 410 <210> 68 <211> 1245 <212> DNA <213> Cuphea heterophylla <400> 68 atggtggcca ccgctgcaag ttctgcattc ttcccggtgc cgtccccgga cacctcctct 60 agaccgggaa agctcggaaa tgggtcatca agcttgaggc ccctcaagcc caaatttgtt 120 gccaatgctg ggctgcaggt taaggcaaac gccagtgccc ctcctaagat caatggttcc 180 tcggtcagtc taaagtcttg cagtctcaag actcatgaag acactccttc agctcctcct 240 ccgcggactt ttatcaacca gttgcctgat tggagcatgc ttcttgctgc aatcactact 300 gtcttcttgg cagcagagaa gcagtggatg atgcttgatt ggaaaccaaa gaggcctgac 360 atgcttgtgg acccgttcgg attgggaagg attgttcagg atgggcttgt gttcaggcag 420 aatttttcga ttaggtccta tgaaataggc gctgatcgca ctgcatccat agagacggtg 480 atgaaccact tgcaggaaac ggctctcaat catgttaaga gtgcggggct tcttaatgaa 540 ggctttggtc gtactcctga gatgtataaa agggacctta tttgggttgt cgcgaaaatg 600 caggtcatgg ttaaccgcta tcctacttgg ggtgacacgg ttgaagtgaa tacttgggtt 660 gccaagtcag ggaaaaatgg tatgcgtcgt gattggctca taagtgattg caatacagga 720 gaaattctta caagggcatc aagtgtgtgg gtcatgatga atcaaaagac aagaaaattg 780 tcaaagattc cagatgaggt tcggcatgag atagagcctc attttgtgga ctctgctccc 840 gtcattgaag acgatgactg gaaacttccc aagctggatg agaaaactgc tgactccatc 900 cgcaagggtc taactccgaa gtggaatgac ttggatgtca atcagcacgt caacaacgtg 960 aagtacattg ggtggattct tgagagtact ccaccagaag ttctggagac ccaggagtta 1020 tgttccctta ccctggaata caggcgggaa tgcggaaggg agagtgtgct ggagtccctc 1080 actgctgtgg acccctctgg aaagggcttt gggccccagt ttcagcacct tctgaggctt 1140 gaggatggag gtgagatcgt aaaggggaga actgagtggc gacccaagac tgcaggtatc 1200 aatgggacga ttgcatctgg ggagacctca cctggaaact cttag 1245 <210> 69 <211> 1245 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 69 atggtggcca ccgccgcctc ctccgccttc ttccccgtgc cctcccccga cacctcctcc 60 cgccccggca agctgggcaa cggctcctcc tccctgcgcc ccctgaagcc caagttcgtg 120 gccaacgccg gcctgcaggt gaaggccaac gcctccgccc cccccaagat caacggctcc 180 tccgtgtccc tgaagtcctg ctccctgaag acccacgagg acaccccctc cgcccccccc 240 ccccgcacct tcatcaacca gctgcccgac tggtccatgc tgctggccgc catcaccacc 300 gtgttcctgg ccgccgagaa gcagtggatg atgctggact ggaagcccaa gcgccccgac 360 atgctggtgg accccttcgg cctgggccgc atcgtgcagg acggcctggt gttccgccag 420 aacttctcca tccgctccta cgagatcggc gccgaccgca ccgcctccat cgagaccgtg 480 atgaaccacc tgcaggagac cgccctgaac cacgtgaagt ccgccggcct gctgaacgag 540 ggcttcggcc gcacccccga gatgtacaag cgcgacctga tctgggtggt ggccaagatg 600 caggtgatgg tgaaccgcta ccccacctgg ggcgacaccg tggaggtgaa cacctgggtg 660 gccaagtccg gcaagaacgg catgcgccgc gactggctga tctccgactg caacaccggc 720 gagatcctga cccgcgcctc ctccgtgtgg gtgatgatga accagaagac ccgcaagctg 780 tccaagatcc ccgacgaggt gcgccacgag atcgagcccc acttcgtgga ctccgccccc 840 gtgatcgagg acgacgactg gaagctgccc aagctggacg agaagaccgc cgactccatc 900 cgcaagggcc tgacccccaa gtggaacgac ctggacgtga accagcacgt gaacaacgtg 960 aagtacatcg gctggatcct ggagtccacc ccccccgagg tgctggagac ccaggagctg 1020 tgctccctga ccctggagta ccgccgcgag tgcggccgcg agtccgtgct ggagtccctg 1080 accgccgtgg acccctccgg caagggcttc ggcccccagt tccagcacct gctgcgcctg 1140 gaggacggcg gcgagatcgt gaagggccgc accgagtggc gccccaagac cgccggcatc 1200 aacggcacca tcgcctccgg cgagacctcc cccggcaact cctga 1245 <210> 70 <211> 414 <212> PRT <213> Cuphea heterophylla <400> 70 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Thr Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Arg Pro Leu Lys Pro Lys Phe Val Ala Asn Ala Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Ser Leu 50 55 60 Lys Ser Gly Ser Leu Lys Thr Gln Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly Phe 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Ile Glu Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Lys Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Trp Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys 355 360 365 Gly Phe Gly Pro Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile 385 390 395 400 Asn Gly Thr Ile Ala Ser Gly Glu Thr Ser Pro Gly Asn Ser 405 410 <210> 71 <211> 1245 <212> DNA <213> Cuphea heterophylla <400> 71 atggtggcca ccgctgcaag ttctgcattc ttcccggtgc catccccgga cacctcctct 60 agaccgggaa agctcggaaa tgggtcatca agcttgaggc ccctcaagcc caaatttgtt 120 gccaatgctg ggctgcaggt taaggcaaac gccagtgccc ctcctaagat caatggttcc 180 tcggtcagtc taaagtctgg cagtctcaag actcaggaag acactccttc ggctcctcct 240 ccgcggactt ttatcaacca gttgcctgat tggagcatgc ttcttgctgc aatcactact 300 gtcttcttgg cagcagagaa gcagtggatg atgcttgatt ggaaaccaaa gaggcctgac 360 atgcttgtgg acccgttcgg atttggaagg attgttcagg atgggcttgt gttcaggcag 420 aatttttcga ttaggtccta tgaaataggc gctgatcgca ctgcatctat agagacggtg 480 atgaaccact tgcaggaaac ggctctcaat catgttaaga gtgcggggct tcttattgaa 540 ggctttggtc gtactcctga gatgtataaa agggacctta tttgggttgt cgcgaaaatg 600 caggtcatgg ttaaccgcta tcctacttgg ggtgacacgg ttgaagtgaa tacttgggtt 660 gccaagtcag ggaaaaatgg tatgcgtcgt gattggctca taagtgattg caatacagga 720 gaaattctta ctagagcatc aagtgtgtgg gtcatgatga atcaaaagac aagaaaattg 780 tcaaagattc cagatgaggt tcggcatgag atagagcctc attttgtgga ctctgctccc 840 gtcattgaag acgatgactg gaaacttccc aagctggatg agaaaactgc tgactccatc 900 cgcaagggtc taactccgaa gtggaatgac ttggatgtca atcagcacgt caacaacgtg 960 aagtacattg ggtggattct tgagagtact ccaccagaag ttctggagac ccaggagtta 1020 tgttccctta ccctggaata caggcgggaa tgcggaaggg agagtgtgct ggagtccctc 1080 actgctgtgg acccctctgg aaagggcttt gggccccagt ttcagcacct tctgaggctt 1140 gaggatggag gtgagatcgt aaaggggaga actgagtggc gacccaagac tgcaggtatc 1200 aatgggacga ttgcatctgg ggagacctca cctggaaact cttag 1245 <210> 72 <211> 1245 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 72 atggtggcca ccgccgcctc ctccgccttc ttccccgtgc cctcccccga cacctcctcc 60 cgccccggca agctgggcaa cggctcctcc tccctgcgcc ccctgaagcc caagttcgtg 120 gccaacgccg gcctgcaggt gaaggccaac gcctccgccc cccccaagat caacggctcc 180 tccgtgtccc tgaagtccgg ctccctgaag acccaggagg acaccccctc cgcccccccc 240 ccccgcacct tcatcaacca gctgcccgac tggtccatgc tgctggccgc catcaccacc 300 gtgttcctgg ccgccgagaa gcagtggatg atgctggact ggaagcccaa gcgccccgac 360 atgctggtgg accccttcgg cttcggccgc atcgtgcagg acggcctggt gttccgccag 420 aacttctcca tccgctccta cgagatcggc gccgaccgca ccgcctccat cgagaccgtg 480 atgaaccacc tgcaggagac cgccctgaac cacgtgaagt ccgccggcct gctgatcgag 540 ggcttcggcc gcacccccga gatgtacaag cgcgacctga tctgggtggt ggccaagatg 600 caggtgatgg tgaaccgcta ccccacctgg ggcgacaccg tggaggtgaa cacctgggtg 660 gccaagtccg gcaagaacgg catgcgccgc gactggctga tctccgactg caacaccggc 720 gagatcctga cccgcgcctc ctccgtgtgg gtgatgatga accagaagac ccgcaagctg 780 tccaagatcc ccgacgaggt gcgccacgag atcgagcccc acttcgtgga ctccgccccc 840 gtgatcgagg acgacgactg gaagctgccc aagctggacg agaagaccgc cgactccatc 900 cgcaagggcc tgacccccaa gtggaacgac ctggacgtga accagcacgt gaacaacgtg 960 aagtacatcg gctggatcct ggagtccacc ccccccgagg tgctggagac ccaggagctg 1020 tgctccctga ccctggagta ccgccgcgag tgcggccgcg agtccgtgct ggagtccctg 1080 accgccgtgg acccctccgg caagggcttc ggcccccagt tccagcacct gctgcgcctg 1140 gaggacggcg gcgagatcgt gaagggccgc accgagtggc gccccaagac cgccggcatc 1200 aacggcacca tcgcctccgg cgagacctcc cccggcaact cctga 1245 <210> 73 <211> 419 <212> PRT <213> Cuphea viscosissima <400> 73 Met Val Ala Ala Ala Ala Thr Ser Ala Phe Phe Pro Val Pro Ala Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Ser Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Pro Thr Phe Lys Pro Lys Ser Ile Pro Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Ser Val Gly 115 120 125 Leu Lys Ser Ile Val Arg Asp Gly Leu Val Ser Arg His Ser Phe Ser 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Thr Ile Asn His Cys Lys Ser Leu 165 170 175 Gly Leu His Asn Asp Gly Phe Gly Arg Thr Pro Gly Met Cys Lys Asn 180 185 190 Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg Tyr 195 200 205 Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser Gln Ser 210 215 220 Gly Lys Ile Gly Met Ala Ser Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val Arg Gln Glu Leu 260 265 270 Thr Pro His Phe Val Asp Ser Pro His Val Ile Glu Asp Asn Asp Gln 275 280 285 Lys Leu Arg Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Ser Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Ile Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Val Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Met Asp Ser Val Leu Glu Ser Val Thr Ala Val Asp Pro Ser Glu 355 360 365 Asn Gly Gly Arg Ser Gln Tyr Lys His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Ile Val Lys Ser Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Ala Ile Ser Thr Ser Thr Ala Lys Thr Ser Asn Gly Asn 405 410 415 Ser Val Ser <210> 74 <211> 1260 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 74 atggtggccg ccgccgccac ctccgccttc ttccccgtgc ccgcccccgg cacctccccc 60 aagcccggca agtccggcaa ctggccctcc tccctgtccc ccaccttcaa gcccaagtcc 120 atccccaacg gcggcttcca ggtgaaggcc aacgcctccg cccaccccaa ggccaacggc 180 tccgccgtga acctgaagtc cggctccctg aacacccagg aggacacctc ctcctccccc 240 cccccccgcg ccttcctgaa ccagctgccc gactggtcca tgctgctgac cgccatcacc 300 accgtgttcg tggccgccga gaagcagtgg accatgctgg accgcaagtc caagcgcccc 360 gacatgctgg tggactccgt gggcctgaag tccatcgtgc gcgacggcct ggtgtcccgc 420 cactccttct ccatccgctc ctacgagatc ggcgccgacc gcaccgcctc catcgagacc 480 ctgatgaacc acctgcagga gaccaccatc aaccactgca agtccctggg cctgcacaac 540 gacggcttcg gccgcacccc cggcatgtgc aagaacgacc tgatctgggt gctgaccaag 600 atgcagatca tggtgaaccg ctaccccacc tggggcgaca ccgtggagat caacacctgg 660 ttctcccagt ccggcaagat cggcatggcc tccgactggc tgatctccga ctgcaacacc 720 ggcgagatcc tgatccgcgc cacctccgtg tgggccatga tgaaccagaa gacccgccgc 780 ttctcccgcc tgccctacga ggtgcgccag gagctgaccc cccacttcgt ggactccccc 840 cacgtgatcg aggacaacga ccagaagctg cgcaagttcg acgtgaagac cggcgactcc 900 atccgcaagg gcctgacccc ccgctggaac gacctggacg tgaaccagca cgtgtccaac 960 gtgaagtaca tcggctggat cctggagtcc atgcccatcg aggtgctgga gacccaggag 1020 ctgtgctccc tgaccgtgga gtaccgccgc gagtgcggca tggactccgt gctggagtcc 1080 gtgaccgccg tggacccctc cgagaacggc ggccgctccc agtacaagca cctgctgcgc 1140 ctggaggacg gcaccgacat cgtgaagtcc cgcaccgagt ggcgccccaa gaacgccggc 1200 accaacggcg ccatctccac ctccaccgcc aagacctcca acggcaactc cgtgtcctga 1260 <210> 75 <211> 415 <212> PRT <213> Cuphea viscosissima <400> 75 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Ala 1 5 10 15 Asp Thr Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Pro Ser Ser Phe 20 25 30 Ser Pro Leu Lys Pro Lys Ser Ile Pro Asn Gly Gly Leu Gln Val Lys 35 40 45 Ala Ser Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly Leu 50 55 60 Lys Ser Gly Gly Leu Lys Thr His Asp Asp Ala Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Ala Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Arg Lys Pro Lys Arg Leu Asp Met Leu Glu Asp Pro Phe Gly Leu 115 120 125 Gly Arg Val Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Thr Ala Gly 165 170 175 Leu Ser Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Lys Leu Ser Lys Ile Pro Asp Glu Val Arg Arg Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Arg Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Ser Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Ala 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Glu 355 360 365 Gly Tyr Gly Ser Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly Ile 385 390 395 400 Asn Gly Val Val Pro Ser Glu Glu Ser Ser Pro Gly Asp Tyr Ser 405 410 415 <210> 76 <211> 1248 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 76 atggtggcca ccgccgcctc ctccgccttc ttccccgtgc cctccgccga cacctcctcc 60 cgccccggca agctgggcaa cggcccctcc tccttctccc ccctgaagcc caagtccatc 120 cccaacggcg gcctgcaggt gaaggcctcc gcctccgccc cccccaagat caacggctcc 180 tccgtgggcc tgaagtccgg cggcctgaag acccacgacg acgccccctc cgcccccccc 240 ccccgcacct tcatcaacca gctgcccgac tggtccatgc tgctggccgc catcaccacc 300 gccttcctgg ccgccgagaa gcagtggatg atgctggacc gcaagcccaa gcgcctggac 360 atgctggagg accccttcgg cctgggccgc gtggtgcagg acggcctggt gttccgccag 420 aacttctcca tccgctccta cgagatcggc gccgaccgca ccgcctccat cgagaccgtg 480 atgaaccacc tgcaggagac cgccctgaac cacgtgaaga ccgccggcct gtccaacgac 540 ggcttcggcc gcacccccga gatgtacaag cgcgacctga tctgggtggt ggccaagatg 600 caggtgatgg tgaaccgcta ccccacctgg ggcgacaccg tggaggtgaa cacctgggtg 660 gccaagtccg gcaagaacgg catgcgccgc gactggctga tctccgactg caacaccggc 720 gagatcctga cccgcgcctc ctccgtgtgg gtgatgatga accagaagac ccgcaagctg 780 tccaagatcc ccgacgaggt gcgccgcgag atcgagcccc acttcgtgga ctccgccccc 840 gtgatcgagg acgacgaccg caagctgccc aagctggacg agaagtccgc cgactccatc 900 cgcaagggcc tgaccccccg ctggaacgac ctggacgtga accagcacgt gaacaacgcc 960 aagtacatcg gctggatcct ggagtccacc ccccccgagg tgctggagac ccaggagctg 1020 tgctccctga ccctggagta ccgccgcgag tgcggccgcg agtccgtgct ggagtccctg 1080 accgccgtgg acccctccgg cgagggctac ggctcccagt tccagcacct gctgcgcctg 1140 gaggacggcg gcgagatcgt gaagggccgc accgagtggc gccccaagaa cgccggcatc 1200 aacggcgtgg tgccctccga ggagtcctcc cccggcgact actcctga 1248 <210> 77 <211> 412 <212> PRT <213> Cuphea viscosissima <400> 77 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Phe Pro Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Ile Pro Phe Asn Pro Lys Ser Asn His Asn Gly Gly Ile Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ala Gly Ser Leu Glu Thr Gln Glu Asp Thr Ser Ser Pro Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Ile Ser Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Val Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Val Leu Val Glu Pro Phe 115 120 125 Val Gln Asp Gly Val Ser Phe Arg Gln Ser Phe Ser Ile Arg Ser Tyr 130 135 140 Glu Ile Gly Val Asp Arg Thr Ala Ser Ile Glu Thr Leu Met Asn Ile 145 150 155 160 Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser Leu Gly Leu Leu Asn 165 170 175 Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu Ile Trp 180 185 190 Val Val Thr Lys Met Gln Ile Glu Val Asn Arg Tyr Pro Thr Trp Gly 195 200 205 Asp Thr Ile Glu Val Thr Thr Trp Val Ser Glu Ser Gly Lys Asn Gly 210 215 220 Met Ser Arg Asp Trp Leu Ile Ser Asp Cys His Ser Gly Glu Ile Leu 225 230 235 240 Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln Lys Thr Arg Arg 245 250 255 Leu Ser Lys Ile Pro Asp Glu Val Arg Gln Glu Ile Val Pro Tyr Phe 260 265 270 Val Asp Ser Ala Pro Val Ile Glu Asp Asp Arg Lys Leu His Lys Leu 275 280 285 Asp Val Lys Thr Gly Asp Ser Ile Arg Asn Gly Leu Thr Pro Arg Trp 290 295 300 Asn Asp Phe Asp Val Asn Gln His Val Asn Asn Val Lys Tyr Ile Ala 305 310 315 320 Trp Leu Leu Lys Ser Val Pro Thr Glu Val Phe Glu Thr Gln Glu Leu 325 330 335 Cys Gly Leu Thr Leu Glu Tyr Arg Arg Glu Cys Arg Arg Asp Ser Val 340 345 350 Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys Glu Gly Asp Arg Ser 355 360 365 Leu Tyr Gln His Leu Leu Arg Leu Glu Asn Gly Ala Asp Ile Ala Leu 370 375 380 Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly Ala Thr Gly Ala Val 385 390 395 400 Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser Val Ser 405 410 <210> 78 <211> 1239 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 78 atggtggccg ccgccgcctc ctccgccttc ttctccttcc ccacccccgg cacctccccc 60 aagcccggca agttcggcaa ctggccctcc tccctgtcca tccccttcaa ccccaagtcc 120 aaccacaacg gcggcatcca ggtgaaggcc aacgcctccg cccaccccaa ggccaacggc 180 tccgccgtgt ccctgaaggc cggctccctg gagacccagg aggacacctc ctccccctcc 240 cccccccccc gcaccttcat ctcccagctg cccgactggt ccatgctggt gtccgccatc 300 accaccgtgt tcgtggccgc cgagaagcag tggaccatgc tggaccgcaa gtccaagcgc 360 cccgacgtgc tggtggagcc cttcgtgcag gacggcgtgt ccttccgcca gtccttctcc 420 atccgctcct acgagatcgg cgtggaccgc accgcctcca tcgagaccct gatgaacatc 480 ttccaggaga cctccctgaa ccactgcaag tccctgggcc tgctgaacga cggcttcggc 540 cgcacccccg agatgtgcaa gcgcgacctg atctgggtgg tgaccaagat gcagatcgag 600 gtgaaccgct accccacctg gggcgacacc atcgaggtga ccacctgggt gtccgagtcc 660 ggcaagaacg gcatgtcccg cgactggctg atctccgact gccactccgg cgagatcctg 720 atccgcgcca cctccgtgtg ggccatgatg aaccagaaga cccgccgcct gtccaagatc 780 cccgacgagg tgcgccagga gatcgtgccc tacttcgtgg actccgcccc cgtgatcgag 840 gacgaccgca agctgcacaa gctggacgtg aagaccggcg actccatccg caacggcctg 900 accccccgct ggaacgactt cgacgtgaac cagcacgtga acaacgtgaa gtacatcgcc 960 tggctgctga agtccgtgcc caccgaggtg ttcgagaccc aggagctgtg cggcctgacc 1020 ctggagtacc gccgcgagtg ccgccgcgac tccgtgctgg agtccgtgac cgccatggac 1080 ccctccaagg agggcgaccg ctccctgtac cagcacctgc tgcgcctgga gaacggcgcc 1140 gacatcgccc tgggccgcac cgagtggcgc cccaagaacg ccggcgccac cggcgccgtg 1200 tccaccggca agacctccaa cggcaactcc gtgtcctga 1239 <210> 79 <211> 417 <212> PRT <213> Cuphea calcarata <400> 79 Met Val Ala Ala Ser Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Pro Arg Ser Asn Asn Ser Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Glu Thr Gln Glu Asp Asn Ser Ser Ser Ser 65 70 75 80 Arg Pro Pro Arg Thr Phe Ile Lys Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 100 105 110 Met Phe Asp Arg Lys Ser Lys Arg Ser Asp Met Leu Val Asp Pro Phe 115 120 125 Val Val Asp Arg Ile Val Gln Asp Gly Val Leu Phe Arg Gln Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Met Gly Leu Leu Tyr Glu Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Val Thr Lys Ile His Ile Lys Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Ile Glu Val Thr Thr Trp Val Ser Glu 210 215 220 Ser Gly Lys Asn Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys His 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn 245 250 255 Gln Thr Thr Arg Arg Leu Ser Lys Phe Pro Tyr Glu Leu Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ser Asp Pro Val Ile Glu Asp Asn Arg 275 280 285 Arg Leu Leu Asn Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Val Pro Thr Glu Val Phe 325 330 335 Asp Thr Arg Glu Leu Cys Gly Leu Thr Leu Glu Tyr Arg Gln Glu Cys 340 345 350 Gly Arg Gly Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys 355 360 365 Glu Gly Asp Arg Ser Leu Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Pro Val Ser Thr Arg Lys Thr Thr Asn Gly Ser Ser Val 405 410 415 Ser <210> 80 <211> 1254 <212> DNA <213> Cuphea calcarata <400> 80 atggtggctg cttcagcaag ttctgcattc ttctccgtcc caaccccggg aacctctcct 60 aaacccggga agttcggcaa ttggccatcg agcttgagcg tcccattcaa gcccagatca 120 aacaacagtg gcggctttca ggttaaggca aacgccagtg ctcatcctaa ggctaacggt 180 tctgcagtaa gtctaaagtc tgggagcctc gagactcagg aggacaattc gtcgtcgtct 240 cgtcctcctc ggactttcat taaacagttg ccggactgga gtatgcttct ttccgcgatc 300 acaaccgtct tcgtggcggc tgagaagcag tggacgatgt ttgatcggaa atctaagagg 360 tctgacatgc tcgtggaccc gtttgtggtt gacaggattg ttcaggatgg ggttctgttc 420 agacagagtt tttcgattag gtcttacgaa ataggcgctg atcgaacagc ctctattgag 480 acgctgatga acatcttcca ggaaacatct ctcaatcatt gtaagagtat gggtcttctc 540 tatgaaggct ttggtcgtac tcctgagatg tgtaagaggg acctcatttg ggtggttacg 600 aaaatacata tcaaggtgaa tcgctatccg acttggggtg atactatcga ggtcactact 660 tgggtctccg agtcgggcaa aaacggtatg ggtcgcgatt ggctgataag tgattgccat 720 acaggagaaa ttcttataag agcaacgagt gtgtgggcta tgatgaatca aacgacgaga 780 agattgtcga aatttccata tgagcttcga caggagatag cgccacattt tgtggactcg 840 gatcctgtca ttgaagacaa tcgaagattg ctcaactttg atgtgaagac gggtgattcc 900 attcgcaagg gtctaactcc aaggtggaat gacttggatg tcaatcagca cgttaacaat 960 gtgaagtaca ttgggtggat tctcgagagt gttccaacag aagttttcga tacccgggag 1020 ctatgcggcc tcacccttga gtataggcag gaatgcggaa gaggaagtgt gctggagtcc 1080 gtgaccgcta tggatccctc aaaagaggga gaccggtctc tgtaccagca ccttcttcgg 1140 cttgaggatg ggactgatat cgtgaagggc agaaccgagt ggcggccaaa gaatgcagga 1200 accaatgggc cagtatcaac aagaaagact acaaatggaa gctcagtctc ttag 1254 <210> 81 <211> 1254 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 81 atggtggccg cctccgcctc ctccgccttc ttctccgtgc ccacccccgg cacctccccc 60 aagcccggca agttcggcaa ctggccctcc tccctgtccg tgcccttcaa gccccgctcc 120 aacaactccg gcggcttcca ggtgaaggcc aacgcctccg cccaccccaa ggccaacggc 180 tccgccgtgt ccctgaagtc cggctccctg gagacccagg aggacaactc ctcctcctcc 240 cgcccccccc gcaccttcat caagcagctg cccgactggt ccatgctgct gtccgccatc 300 accaccgtgt tcgtggccgc cgagaagcag tggaccatgt tcgaccgcaa gtccaagcgc 360 tccgacatgc tggtggaccc cttcgtggtg gaccgcatcg tgcaggacgg cgtgctgttc 420 cgccagtcct tctccatccg ctcctacgag atcggcgccg accgcaccgc ctccatcgag 480 accctgatga acatcttcca ggagacctcc ctgaaccact gcaagtccat gggcctgctg 540 tacgagggct tcggccgcac ccccgagatg tgcaagcgcg acctgatctg ggtggtgacc 600 aagatccaca tcaaggtgaa ccgctacccc acctggggcg acaccatcga ggtgaccacc 660 tgggtgtccg agtccggcaa gaacggcatg ggccgcgact ggctgatctc cgactgccac 720 accggcgaga tcctgatccg cgccacctcc gtgtgggcca tgatgaacca gaccacccgc 780 cgcctgtcca agttccccta cgagctgcgc caggagatcg ccccccactt cgtggactcc 840 gaccccgtga tcgaggacaa ccgccgcctg ctgaacttcg acgtgaagac cggcgactcc 900 atccgcaagg gcctgacccc ccgctggaac gacctggacg tgaaccagca cgtgaacaac 960 gtgaagtaca tcggctggat cctggagtcc gtgcccaccg aggtgttcga cacccgcgag 1020 ctgtgcggcc tgaccctgga gtaccgccag gagtgcggcc gcggctccgt gctggagtcc 1080 gtgaccgcca tggacccctc caaggagggc gaccgctccc tgtaccagca cctgctgcgc 1140 ctggaggacg gcaccgacat cgtgaagggc cgcaccgagt ggcgccccaa gaacgccggc 1200 accaacggcc ccgtgtccac ccgcaagacc accaacggct cctccgtgtc ctga 1254 <210> 82 <211> 415 <212> PRT <213> Cuphea painteri <400> 82 Met Val Ala Ala Ala Ala Thr Ser Ala Phe Phe Pro Val Pro Ala Pro 1 5 10 15 Gly Thr Ser Pro Asn Pro Arg Lys Phe Gly Ser Trp Pro Ser Ser Leu 20 25 30 Ser Pro Ser Leu Pro Lys Ser Ile Pro Asn Gly Gly Phe Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Ser Leu 50 55 60 Lys Ser Gly Ser Leu Asn Thr Gln Glu Asn Thr Ser Ser Ser Pro Pro 65 70 75 80 Pro Arg Thr Phe Leu His Gln Leu Pro Asp Trp Ser Arg Leu Leu Thr 85 90 95 Ala Ile Thr Thr Val Phe Val Lys Ser Lys Arg Pro Asp Met His Asp 100 105 110 Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Leu Phe Gly Leu Glu 115 120 125 Ser Ser Val Gln Asp Ala Leu Val Phe Arg Gln Ser Phe Ser Ile Arg 130 135 140 Ser Tyr Glu Ile Gly Thr Asp Arg Thr Ala Ser Ile Glu Thr Leu Met 145 150 155 160 Asn His Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser Thr Gly Ile 165 170 175 Leu Leu Asp Gly Phe Gly Arg Thr Leu Glu Met Cys Lys Arg Glu Leu 180 185 190 Ile Trp Val Val Ile Lys Met Gln Ile Gln Val Asn Arg Tyr Pro Ala 195 200 205 Trp Gly Asp Thr Val Glu Ile Asn Thr Arg Phe Ser Arg Leu Gly Lys 210 215 220 Ile Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly Glu 225 230 235 240 Ile Leu Ile Arg Ala Thr Ser Glu Tyr Ala Met Met Asn Gln Lys Thr 245 250 255 Arg Arg Leu Ser Lys Leu Pro Tyr Glu Val His Gln Glu Ile Ala Pro 260 265 270 Leu Phe Val Asp Ser Pro Pro Val Ile Glu Asp Asn Asp Leu Lys Val 275 280 285 His Lys Phe Glu Val Lys Thr Gly Asp Ser Ile Gln Lys Gly Leu Ser 290 295 300 Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Ser Asn Val Lys 305 310 315 320 Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val Leu Glu Thr 325 330 335 Gln Glu Leu Cys Ser Leu Ala Leu Glu Tyr Arg Arg Glu Cys Gly Arg 340 345 350 Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys Val Gly 355 360 365 Gly Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp Gly Thr Ala 370 375 380 Ile Val Asn Gly Ile Thr Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn 385 390 395 400 Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser Val Ser 405 410 415 <210> 83 <211> 1248 <212> DNA <213> Cuphea painteri <400> 83 atggtggctg ctgcagcaac ttctgcattc ttccctgttc cagccccggg aacctcccca 60 aatcccagga aattcggaag ttggccatcg agcttgagcc cttccttgcc caagtcaatc 120 cccaatggcg gatttcaggt aaaggcaaat gccagtgccc atccgaaggc taacggttct 180 gcagttagtc taaagtctgg cagcctcaac actcaggaga acacttcgtc gtcccctcct 240 cctcggactt tccttcacca gttgcctgat tggagtaggc ttctgactgc aatcacgacc 300 gtgttcgtga aatctaagag gcctgacatg catgatcgga aatctaagag gcctgacatg 360 ctggtggact tgtttgggtt ggaaagtagt gttcaggatg cgctcgtgtt cagacagagt 420 ttttcgatta ggtcttatga aataggcact gatcgaacag cctctataga gacgctgatg 480 aaccacttgc aggaaacatc tctcaatcat tgtaaaagta ccggtattct ccttgacggc 540 ttcggtcgta ctcttgagat gtgtaaaagg gaactcattt gggtggtaat aaaaatgcaa 600 attcaggtga atcgctatcc agcatggggc gatactgtcg agatcaatac ccggttctcc 660 cggttgggga aaattggtat gggtcgcgat tggctaataa gtgattgcaa cacaggagaa 720 attctaataa gagcaacgag cgagtatgcc atgatgaatc aaaagacgag aagactctca 780 aaacttccat acgaggttca ccaggagata gcgcctcttt ttgtcgactc tcctcctgtg 840 attgaagaca atgatctgaa agtgcataaa tttgaagtga agactggtga ttccattcaa 900 aagggtctat ccccggggtg gaatgacttg gatgtcaatc agcacgtaag caacgtgaag 960 tacattgggt ggattctcga gagtatgcca acagaagttt tggagaccca ggagctatgc 1020 tctctcgccc ttgaatatag gcgggaatgc ggaagggaca gtgtgctgga gtccgtgacc 1080 gcaatggatc cctcaaaagt tggaggccgt tctcagtacc agcaccttct gcggcttgag 1140 gatgggactg ctatcgtgaa cggcataact gagtggcggc cgaagaatgc aggagctaat 1200 ggggcgatat caacgggaaa gacttcaaat ggaaactcgg tctcttag 1248 <210> 84 <211> 1248 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 84 atggtggccg ccgccgccac ctccgccttc ttccccgtgc ccgcccccgg cacctccccc 60 aacccccgca agttcggctc ctggccctcc tccctgtccc cctccctgcc caagtccatc 120 cccaacggcg gcttccaggt gaaggccaac gcctccgccc accccaaggc caacggctcc 180 gccgtgtccc tgaagtccgg ctccctgaac acccaggaga acacctcctc ctcccccccc 240 ccccgcacct tcctgcacca gctgcccgac tggtcccgcc tgctgaccgc catcaccacc 300 gtgttcgtga agtccaagcg ccccgacatg cacgaccgca agtccaagcg ccccgacatg 360 ctggtggacc tgttcggcct ggagtcctcc gtgcaggacg ccctggtgtt ccgccagtcc 420 ttctccatcc gctcctacga gatcggcacc gaccgcaccg cctccatcga gaccctgatg 480 aaccacctgc aggagacctc cctgaaccac tgcaagtcca ccggcatcct gctggacggc 540 ttcggccgca ccctggagat gtgcaagcgc gagctgatct gggtggtgat caagatgcag 600 atccaggtga accgctaccc cgcctggggc gacaccgtgg agatcaacac ccgcttctcc 660 cgcctgggca agatcggcat gggccgcgac tggctgatct ccgactgcaa caccggcgag 720 atcctgatcc gcgccacctc cgagtacgcc atgatgaacc agaagacccg ccgcctgtcc 780 aagctgccct acgaggtgca ccaggagatc gcccccctgt tcgtggactc cccccccgtg 840 atcgaggaca acgacctgaa ggtgcacaag ttcgaggtga agaccggcga ctccatccag 900 aagggcctgt cccccggctg gaacgacctg gacgtgaacc agcacgtgtc caacgtgaag 960 tacatcggct ggatcctgga gtccatgccc accgaggtgc tggagaccca ggagctgtgc 1020 tccctggccc tggagtaccg ccgcgagtgc ggccgcgact ccgtgctgga gtccgtgacc 1080 gccatggacc cctccaaggt gggcggccgc tcccagtacc agcacctgct gcgcctggag 1140 gacggcaccg ccatcgtgaa cggcatcacc gagtggcgcc ccaagaacgc cggcgccaac 1200 ggcgccatct ccaccggcaa gacctccaac ggcaactccg tgtcctga 1248 <210> 85 <211> 414 <212> PRT <213> Cuphea hookeriana <400> 85 Met Val Ala Ala Ala Ala Thr Ser Ala Phe Phe Pro Val Pro Ala Pro 1 5 10 15 Gly Thr Ser Pro Asn Pro Arg Lys Phe Gly Ser Trp Pro Ser Ser Leu 20 25 30 Ser Pro Ser Leu Pro Asn Ser Ile Pro Asn Gly Gly Phe Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Ser Leu 50 55 60 Lys Ser Gly Ser Leu Asn Thr Gln Glu Asn Thr Ser Ser Ser Pro Pro 65 70 75 80 Pro Arg Thr Phe Leu His Gln Leu Pro Asp Trp Ser Arg Leu Leu Thr 85 90 95 Ala Ile Thr Thr Val Phe Val Lys Ser Lys Arg Pro Asp Met His Asp 100 105 110 Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Leu Phe Gly Leu Glu 115 120 125 Ser Ser Val Gln Asp Ala Leu Val Phe Arg Gln Arg Phe Ser Ile Arg 130 135 140 Ser Tyr Glu Ile Gly Thr Asp Arg Thr Ala Ser Met Glu Thr Leu Met 145 150 155 160 Asn His Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser Thr Gly Ile 165 170 175 Leu Leu Asp Gly Phe Gly Arg Thr Leu Glu Met Cys Lys Arg Glu Leu 180 185 190 Ile Trp Val Val Ile Lys Met Gln Ile Gln Val Asn Arg Tyr Pro Ala 195 200 205 Trp Gly Asp Thr Val Glu Ile Asn Thr Arg Phe Ser Arg Leu Gly Lys 210 215 220 Ile Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly Glu 225 230 235 240 Ile Leu Ile Arg Ala Thr Ser Glu Tyr Ala Met Met Asn Gln Lys Thr 245 250 255 Arg Arg Leu Ser Lys Leu Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro 260 265 270 Leu Phe Val Asp Ser Pro Pro Val Ile Glu Asp Asn Asp Leu Lys Val 275 280 285 His Lys Phe Glu Val Lys Thr Gly Asp Ser Ile His Lys Gly Leu Thr 290 295 300 Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val Lys 305 310 315 320 Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu Thr 325 330 335 Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg 340 345 350 Glu Ser Val Leu Glu Ser Leu Thr Ala Met Asp Pro Ser Gly Gly Gly 355 360 365 Tyr Gly Ser Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly Glu 370 375 380 Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Gly Val Ile Asn 385 390 395 400 Gly Val Val Pro Thr Gly Glu Ser Ser Pro Gly Asp Tyr Ser 405 410 <210> 86 <211> 1245 <212> DNA <213> Cuphea hookeriana <400> 86 atggtggctg ctgcagcaac ttctgcattc ttccctgttc cagccccggg aacctcccct 60 aatcccagga aattcggaag ttggccatcg agcttgagcc cttccttgcc caactcaatc 120 cccaatggcg gatttcaggt aaaggcaaat gccagtgccc atccgaaggc taacggttct 180 gcagttagtc taaagtctgg cagcctcaac actcaggaga acacttcgtc gtcccctcct 240 cctcggactt tccttcacca gttgcctgat tggagtaggc ttctgactgc aatcacgacc 300 gtgttcgtga aatctaagag gcctgacatg catgatcgga aatctaagag gcctgacatg 360 ctggtggact tgtttgggtt ggagagtagt gttcaggatg cgctcgtgtt cagacagaga 420 ttttcgatta ggtcttatga aataggcact gatcgaacag cctctatgga gacgctgatg 480 aaccacttgc aggaaacatc tctcaatcat tgtaaaagta ccggtattct ccttgacggc 540 ttcggtcgta ctcttgagat gtgtaaaagg gaactcattt gggtggtaat aaaaatgcag 600 attcaggtga atcgctatcc agcatggggc gatactgtcg agatcaatac ccggttctcc 660 cggttgggga aaattggtat gggtcgcgat tggctaataa gtgattgcaa cacaggagaa 720 attcttataa gagcaacgag cgagtatgcc atgatgaatc aaaagacgag aagactctca 780 aaacttccat acgaggttcg ccaggagata gcgcctcttt ttgtcgactc tcctcctgtg 840 attgaagaca atgatctgaa agtgcataaa tttgaagtga agactggtga ttccattcac 900 aagggtctaa ctccggggtg gaatgacttg gatgtcaatc agcacgtcaa caacgtgaag 960 tacatcgggt ggattcttga gagtactcca ccagaagttc tggagaccca ggagttatgt 1020 tcccttactc tggaatacag gcgggaatgt ggaagggaga gcgtgctgga gtccctcact 1080 gctatggatc cctctggagg gggttatggg tcccagtttc agcaccttct gcggcttgag 1140 gatggaggtg agatcgtgaa ggggagaacc gagtggcgac ccaagaatgg tgtaatcaat 1200 ggggtggtac caaccgggga gtcctcacct ggagactact cttag 1245 <210> 87 <211> 1245 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 87 atggtggccg ccgccgccac ctccgccttc ttccccgtgc ccgcccccgg cacctccccc 60 aacccccgca agttcggctc ctggccctcc tccctgtccc cctccctgcc caactccatc 120 cccaacggcg gcttccaggt gaaggccaac gcctccgccc accccaaggc caacggctcc 180 gccgtgtccc tgaagtccgg ctccctgaac acccaggaga acacctcctc ctcccccccc 240 ccccgcacct tcctgcacca gctgcccgac tggtcccgcc tgctgaccgc catcaccacc 300 gtgttcgtga agtccaagcg ccccgacatg cacgaccgca agtccaagcg ccccgacatg 360 ctggtggacc tgttcggcct ggagtcctcc gtgcaggacg ccctggtgtt ccgccagcgc 420 ttctccatcc gctcctacga gatcggcacc gaccgcaccg cctccatgga gaccctgatg 480 aaccacctgc aggagacctc cctgaaccac tgcaagtcca ccggcatcct gctggacggc 540 ttcggccgca ccctggagat gtgcaagcgc gagctgatct gggtggtgat caagatgcag 600 atccaggtga accgctaccc cgcctggggc gacaccgtgg agatcaacac ccgcttctcc 660 cgcctgggca agatcggcat gggccgcgac tggctgatct ccgactgcaa caccggcgag 720 atcctgatcc gcgccacctc cgagtacgcc atgatgaacc agaagacccg ccgcctgtcc 780 aagctgccct acgaggtgcg ccaggagatc gcccccctgt tcgtggactc cccccccgtg 840 atcgaggaca acgacctgaa ggtgcacaag ttcgaggtga agaccggcga ctccatccac 900 aagggcctga cccccggctg gaacgacctg gacgtgaacc agcacgtgaa caacgtgaag 960 tacatcggct ggatcctgga gtccaccccc cccgaggtgc tggagaccca ggagctgtgc 1020 tccctgaccc tggagtaccg ccgcgagtgc ggccgcgagt ccgtgctgga gtccctgacc 1080 gccatggacc cctccggcgg cggctacggc tcccagttcc agcacctgct gcgcctggag 1140 gacggcggcg agatcgtgaa gggccgcacc gagtggcgcc ccaagaacgg cgtgatcaac 1200 ggcgtggtgc ccaccggcga gtcctccccc ggcgactact cctga 1245 <210> 88 <211> 416 <212> PRT <213> Cuphea avigera <400> 88 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Val Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Arg Ile Trp Pro Ser Ser Leu 20 25 30 Ser Pro Ser Phe Lys Pro Lys Pro Ile Pro Asn Gly Gly Leu Gln Val 35 40 45 Lys Ala Asn Ser Arg Ala His Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Thr Phe Leu His Gln Leu Pro Asp Trp Ser Arg Leu Leu 85 90 95 Thr Ala Ile Thr Thr Val Phe Val Lys Ser Lys Arg Pro Asp Met His 100 105 110 Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Met Asp Ser Phe Gly Leu 115 120 125 Glu Ser Ile Val Gln Glu Gly Leu Glu Phe Arg Gln Ser Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Thr Asp Arg Thr Ala Ser Ile Glu Thr Leu 145 150 155 160 Met Asn Tyr Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser Thr Gly 165 170 175 Ile Leu Leu Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Thr Lys Met Lys Ile Lys Val Asn Arg Tyr Pro 195 200 205 Ala Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser Arg Leu Gly 210 215 220 Lys Ile Gly Lys Gly Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Ile Arg Ala Thr Ser Ala Tyr Ala Thr Met Asn Gln Lys 245 250 255 Thr Arg Arg Leu Ser Lys Leu Pro Tyr Glu Val His Gln Glu Ile Ala 260 265 270 Pro Leu Phe Val Asp Ser Pro Pro Val Ile Glu Asp Asn Asp Leu Lys 275 280 285 Leu His Lys Phe Glu Val Lys Thr Gly Asp Ser Ile His Lys Gly Leu 290 295 300 Thr Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Ser Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Ala Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Thr Lys Val 355 360 365 Gly Gly Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp Gly Thr 370 375 380 Asp Ile Val Lys Cys Arg Thr Glu Trp Arg Pro Lys Asn Pro Gly Ala 385 390 395 400 Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser Val Ser 405 410 415 <210> 89 <211> 1251 <212> DNA <213> Cuphea avigera <400> 89 atggtggctg ctgcagcaag ttctgcattc ttctctgttc cagtcccggg aacctctcct 60 aaacccggga agttcagaat ttggccatcg agcttgagcc cttccttcaa gcccaagccg 120 atccccaatg gtggattgca ggttaaggca aattccaggg cacatccgaa ggctaacggt 180 tctgcagtta gtctaaagtc tggcagcctc aacactcagg aggacacttc gtcgtcccct 240 cctcctcgga ctttccttca ccagttgcct gattggagta ggcttctgac tgcaatcacg 300 accgtgttcg tgaaatctaa gaggcctgac atgcatgatc ggaaatctaa gaggcctgac 360 atgctgatgg actcgtttgg gttggagagt attgttcaag aagggctcga gttcagacag 420 agtttttcga ttaggtctta tgaaataggc actgatcgaa cagcctctat agagacgctg 480 atgaactact tgcaggaaac atctctcaat cattgtaaga gtaccggtat tctccttgac 540 ggctttggtc gtactcctga gatgtgtaaa agggacctca tttgggtggt aacaaaaatg 600 aagatcaagg tgaatcgcta tccagcttgg ggcgatactg tcgagatcaa tacctggttc 660 tcccggttgg ggaaaatcgg aaagggtcgc gattggctaa taagtgattg caacacagga 720 gaaattctta taagagcaac gagcgcgtat gccacgatga atcaaaagac gagaagactc 780 tcaaaacttc catacgaggt tcaccaggag atagcgcctc tctttgtcga ctctcctcct 840 gtcattgaag acaatgatct gaaattgcat aagtttgaag tgaagactgg tgattccatt 900 cacaagggtc taactccggg gtggaatgac ttggatgtca atcagcacgt aagcaacgtg 960 aagtacattg ggtggattct cgagagtatg ccaacagaag ttttggagac ccaggagcta 1020 tgctctctcg cccttgaata taggcgggaa tgcggaaggg acagtgtgct agagtccgtg 1080 acagctatgg atcccacaaa agttggaggc cggtctcagt accagcacct tctgcgactt 1140 gaggatggga ctgatatcgt gaagtgcaga actgagtggc ggccgaagaa tccaggagct 1200 aatggggcaa tatcaacggg aaagacttca aatggaaact cggtctctta g 1251 <210> 90 <211> 1248 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 90 atggtggccg ccgccgcctc ctccgccttc ttctccgtgc ccgtgcccgg cacctccccc 60 aagcccggca agttccgcat ctggccctcc tccctgtccc cctccttcaa gcccaagccc 120 atccccaacg gcggcctgca ggtgaaggcc aactcccgcg cccaccccaa ggccaacggc 180 tccgccgtgt ccctgaagtc cggctccctg aacacccagg aggacacctc ctcctccccc 240 cccccccgca ccttcctgca ccagctgccc gactggtccc gcctgctgac cgccatcacc 300 accgtgttcg tgaagtccaa gcgccccgac atgcacgacc gcaagtccaa gcgccccgac 360 atgctgatgg actccttcgg cctggagtcc atcgtgcagg agggcctgga gttccgccag 420 tccttctcca tccgctccta cgagatcggc accgaccgca ccgcctccat cgagaccctg 480 atgaactacc tgcaggagac ctccctgaac cactgcaagt ccaccggcat cctgctggac 540 ggcttcggcc gcacccccga gatgtgcaag cgcgacctga tctgggtggt gaccaagatg 600 aagatcaagg tgaaccgcta ccccgcctgg ggcgacaccg tggagatcaa cacctggttc 660 tcccgcctgg gcaagatcgg caagggccgc gactggctga tctccgactg caacaccggc 720 gagatcctga tccgcgccac ctccgcctac gccaccatga accagaagac ccgccgcctg 780 tccaagctgc cctacgaggt gcaccaggag atcgcccccc tgttcgtgga ctcccccccc 840 gtgatcgagg acaacgacct gaagctgcac aagttcgagg tgaagaccgg cgactccatc 900 cacaagggcc tgacccccgg ctggaacgac ctggacgtga accagcacgt gtccaacgtg 960 aagtacatcg gctggatcct ggagtccatg cccaccgagg tgctggagac ccaggagctg 1020 tgctccctgg ccctggagta ccgccgcgag tgcggccgcg actccgtgct ggagtccgtg 1080 accgccatgg accccaccaa ggtgggcggc cgctcccagt accagcacct gctgcgcctg 1140 gaggacggca ccgacatcgt gaagtgccgc accgagtggc gccccaagaa ccccggcgcc 1200 aacggcgcca tctccaccgg caagacctcc aacggcaact ccgtgtcc 1248 <210> 91 <211> 417 <212> PRT <213> Cuphea paucipetala <400> 91 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Ser Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Pro Ser Ile Lys Pro Met Ser Ile Pro Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Arg Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Ser Val Gly 115 120 125 Leu Lys Ser Val Val Leu Asp Gly Leu Val Ser Arg Gln Ile Phe Ser 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His Cys Lys Ser Leu 165 170 175 Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly Met Cys Lys Asn 180 185 190 Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg Tyr 195 200 205 Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser His Ser 210 215 220 Gly Lys Ile Gly Met Ala Ser Asp Trp Leu Ile Thr Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val Arg Gln Glu Leu 260 265 270 Thr Pro His Tyr Val Asp Ser Pro His Val Ile Glu Asp Asn Asp Arg 275 280 285 Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Ser Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Ile Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Val Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Met Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Glu 355 360 365 Asp Glu Gly Arg Ser Gln Tyr Lys His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Ala Ile Ser Thr Ala Lys Pro Ser Asn Gly Asn Ser Val 405 410 415 Ser <210> 92 <211> 1254 <212> DNA <213> Cuphea paucipetala <400> 92 atggtggctg ctgcagcaag ttctgcattc ttccctgttc cagcccccgg aacctcccct 60 aaacccggga agtccggcaa ctggccatca agcttgagcc cttccatcaa gcccatgtca 120 atccccaatg gcggatttca ggttaaggca aatgccagtg cccatcctaa ggctaacggt 180 tctgcagtaa atctaaagtc tggcagcctc aacactcagg aggacacttc gtcgtcccct 240 cctcctcggg ctttccttaa ccagttgcct gattggagta tgcttctgac tgcaatcacg 300 accgtcttcg tggcggcaga gaagcagtgg actatgcgtg atcggaaatc taagaggcct 360 gacatgctcg tggactcggt tgggttgaag agtgttgttc tggatgggct cgtgtccaga 420 cagatttttt cgattaggtc ttatgaaata ggcgctgatc gaactgcctc tatagagacg 480 ctgatgaacc acttgcagga aacatctatc aatcattgta agagtttggg tcttctcaat 540 gacggctttg gtcgtactcc tgggatgtgt aaaaatgacc tcatttgggt gcttacaaaa 600 atgcagatca tggtgaatcg ctacccaact tggggcgata ctgttgagat caatacctgg 660 ttctcccatt cggggaaaat tggtatggct agcgattggc taataactga ttgcaacaca 720 ggagaaattc ttataagagc aacgagcgtg tgggccatga tgaatcaaaa gacgagaaga 780 ttctcaagac ttccatacga ggttcgccag gagttaacgc ctcattatgt ggactctcct 840 catgtcattg aagataatga tcggaaattg cataagtttg atgtgaagac tggtgattcc 900 attcgtaagg gtctaactcc gaggtggaat gacttggatg tcaatcagca cgtaagcaac 960 gtgaagtaca ttgggtggat tctcgagagt atgccaatag aagttttgga gacccaggag 1020 ctatgctctc tcaccgttga atataggcgg gaatgcggaa tggacagtgt gctggagtcc 1080 gtgactgcta tggatccctc agaagatgaa ggccggtctc agtacaagca ccttctgcgg 1140 cttgaggatg ggactgacat cgtgaagggc agaactgagt ggcgaccgaa gaatgcagga 1200 actaacgggg cgatatcaac agcaaagcct tcaaatggaa actcggtctc ttag 1254 <210> 93 <211> 1254 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 93 atggtggccg ccgccgcctc ctccgccttc ttccccgtgc ccgcccccgg cacctccccc 60 aagcccggca agtccggcaa ctggccctcc tccctgtccc cctccatcaa gcccatgtcc 120 atccccaacg gcggcttcca ggtgaaggcc aacgcctccg cccaccccaa ggccaacggc 180 tccgccgtga acctgaagtc cggctccctg aacacccagg aggacacctc ctcctccccc 240 cccccccgcg ccttcctgaa ccagctgccc gactggtcca tgctgctgac cgccatcacc 300 accgtgttcg tggccgccga gaagcagtgg accatgcgcg accgcaagtc caagcgcccc 360 gacatgctgg tggactccgt gggcctgaag tccgtggtgc tggacggcct ggtgtcccgc 420 cagatcttct ccatccgctc ctacgagatc ggcgccgacc gcaccgcctc catcgagacc 480 ctgatgaacc acctgcagga gacctccatc aaccactgca agtccctggg cctgctgaac 540 gacggcttcg gccgcacccc cggcatgtgc aagaacgacc tgatctgggt gctgaccaag 600 atgcagatca tggtgaaccg ctaccccacc tggggcgaca ccgtggagat caacacctgg 660 ttctcccact ccggcaagat cggcatggcc tccgactggc tgatcaccga ctgcaacacc 720 ggcgagatcc tgatccgcgc cacctccgtg tgggccatga tgaaccagaa gacccgccgc 780 ttctcccgcc tgccctacga ggtgcgccag gagctgaccc cccactacgt ggactccccc 840 cacgtgatcg aggacaacga ccgcaagctg cacaagttcg acgtgaagac cggcgactcc 900 atccgcaagg gcctgacccc ccgctggaac gacctggacg tgaaccagca cgtgtccaac 960 gtgaagtaca tcggctggat cctggagtcc atgcccatcg aggtgctgga gacccaggag 1020 ctgtgctccc tgaccgtgga gtaccgccgc gagtgcggca tggactccgt gctggagtcc 1080 gtgaccgcca tggacccctc cgaggacgag ggccgctccc agtacaagca cctgctgcgc 1140 ctggaggacg gcaccgacat cgtgaagggc cgcaccgagt ggcgccccaa gaacgccggc 1200 accaacggcg ccatctccac cgccaagccc tccaacggca actccgtgtc ctga 1254 <210> 94 <211> 417 <212> PRT <213> Cuphea procumbens <400> 94 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Ala Pro Ala Pro 1 5 10 15 Gly Ser Ser Pro Lys Pro Gly Lys Ser Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Pro Ser Phe Lys Ser Lys Ser Ile Pro Tyr Gly Arg Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Ser Val Gly 115 120 125 Leu Lys Asn Ile Val Arg Asp Gly Leu Val Ser Arg Gln Ser Phe Leu 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His Cys Lys Ser Leu 165 170 175 Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly Met Cys Lys Asn 180 185 190 Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg Tyr 195 200 205 Pro Ala Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser Gln Ser 210 215 220 Gly Lys Ile Gly Met Gly Ser Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val Arg Gln Glu Leu 260 265 270 Thr Pro His Phe Val Asp Ser Pro His Val Ile Glu Asp Asn Asp Arg 275 280 285 Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Ser Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Ile Glu Val Leu 325 330 335 Glu Ala Gln Glu Leu Cys Ser Leu Thr Val Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Met Asp Ser Val Leu Glu Ser Val Thr Ala Val Asp Pro Ser Glu 355 360 365 Asp Gly Gly Arg Ser Gln Tyr Asn His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Val Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Glu 385 390 395 400 Thr Asn Gly Ala Ile Ser Pro Gly Asn Thr Ser Asn Gly Asn Ser Ile 405 410 415 Ser <210> 95 <211> 1254 <212> DNA <213> Cuphea procumbens <400> 95 atggtggctg ctgcagcaag ttctgcattc ttccctgctc cagccccggg atcctcacct 60 aaacccggga agtccggtaa ttggccatcg agcttgagcc cttccttcaa gtccaagtca 120 atcccctatg gccgatttca ggttaaggca aatgccagtg cccatcctaa ggctaacggt 180 tctgcagtaa atctaaagtc tggcagcctc aacactcagg aggacacttc gtcgtcccct 240 cctcctcggg ctttccttaa ccagttgcct gattggagta tgcttctgtc tgcaatcacg 300 actgtattcg tggcggcaga gaagcagtgg actatgcttg atcggaaatc taagaggcct 360 gacatgcttg tggactcggt tgggttgaag aatattgttc gggatgggct cgtgtccaga 420 cagagttttt tgattagatc ttatgaaata ggcgctgatc gaacagcttc tatagagaca 480 ctgatgaacc acttgcagga aacatctatc aatcattgta agagtttggg tcttctcaat 540 gacggctttg gtcgtactcc tgggatgtgt aaaaacgacc tcatttgggt gcttactaaa 600 atgcagatca tggtgaatcg ctacccagct tggggcgata ctgttgagat caatacctgg 660 ttctcccagt cggggaaaat cggtatgggt agcgattggc taataagtga ttgcaacaca 720 ggagaaattc ttataagagc aacgagcgtg tgggccatga tgaatcaaaa aacgagaaga 780 ttctcaagac ttccatacga ggttcgccag gagttaacgc ctcattttgt ggactctcct 840 catgtcattg aagacaatga tcggaaattg cataagttcg atgtgaagac tggtgattct 900 attcgcaagg gtctaactcc gaggtggaat gacttggatg tcaatcagca cgtgagcaac 960 gtgaagtaca ttgggtggat tctcgagagt atgccaatag aagttttgga ggcccaggaa 1020 ctatgctctc tcaccgttga atataggcgg gaatgcggaa tggacagtgt gctggagtcc 1080 gtgactgctg tagatccctc agaagatgga ggccggtctc agtacaatca ccttctgcgg 1140 cttgaggatg ggactgatgt cgtgaagggc agaactgagt ggcgaccgaa gaatgcagaa 1200 actaacgggg cgatatcacc aggaaacact tcaaatggaa actcgatctc ctag 1254 <210> 96 <211> 1254 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 96 atggtggccg ccgccgcctc ctccgccttc ttccccgccc ccgcccccgg ctcctccccc 60 aagcccggca agtccggcaa ctggccctcc tccctgtccc cctccttcaa gtccaagtcc 120 atcccctacg gccgcttcca ggtgaaggcc aacgcctccg cccaccccaa ggccaacggc 180 tccgccgtga acctgaagtc cggctccctg aacacccagg aggacacctc ctcctccccc 240 cccccccgcg ccttcctgaa ccagctgccc gactggtcca tgctgctgtc cgccatcacc 300 accgtgttcg tggccgccga gaagcagtgg accatgctgg accgcaagtc caagcgcccc 360 gacatgctgg tggactccgt gggcctgaag aacatcgtgc gcgacggcct ggtgtcccgc 420 cagtccttcc tgatccgctc ctacgagatc ggcgccgacc gcaccgcctc catcgagacc 480 ctgatgaacc acctgcagga gacctccatc aaccactgca agtccctggg cctgctgaac 540 gacggcttcg gccgcacccc cggcatgtgc aagaacgacc tgatctgggt gctgaccaag 600 atgcagatca tggtgaaccg ctaccccgcc tggggcgaca ccgtggagat caacacctgg 660 ttctcccagt ccggcaagat cggcatgggc tccgactggc tgatctccga ctgcaacacc 720 ggcgagatcc tgatccgcgc cacctccgtg tgggccatga tgaaccagaa gacccgccgc 780 ttctcccgcc tgccctacga ggtgcgccag gagctgaccc cccacttcgt ggactccccc 840 cacgtgatcg aggacaacga ccgcaagctg cacaagttcg acgtgaagac cggcgactcc 900 atccgcaagg gcctgacccc ccgctggaac gacctggacg tgaaccagca cgtgtccaac 960 gtgaagtaca tcggctggat cctggagtcc atgcccatcg aggtgctgga ggcccaggag 1020 ctgtgctccc tgaccgtgga gtaccgccgc gagtgcggca tggactccgt gctggagtcc 1080 gtgaccgccg tggacccctc cgaggacggc ggccgctccc agtacaacca cctgctgcgc 1140 ctggaggacg gcaccgacgt ggtgaagggc cgcaccgagt ggcgccccaa gaacgccgag 1200 accaacggcg ccatctcccc cggcaacacc tccaacggca actccatctc ctga 1254 <210> 97 <211> 415 <212> PRT <213> Cuphea procumbens <400> 97 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Ala Pro Ala Pro 1 5 10 15 Gly Ser Ser Pro Lys Pro Gly Lys Ser Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Pro Ser Phe Lys Ser Lys Ser Ile Pro Tyr Gly Arg Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Ser Val Gly 115 120 125 Leu Lys Asn Ile Val Arg Asp Gly Leu Val Ser Arg Gln Ser Phe Leu 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His Cys Lys Ser Leu 165 170 175 Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly Met Cys Lys Asn 180 185 190 Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg Tyr 195 200 205 Pro Ala Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser Gln Ser 210 215 220 Gly Lys Ile Gly Met Gly Ser Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val Arg Gln Glu Leu 260 265 270 Thr Pro His Phe Val Asp Ser Pro His Val Ile Glu Asp Asn Asp Arg 275 280 285 Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Gln Glu Cys 340 345 350 Gly Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly 355 360 365 Lys Gly Phe Gly Ser Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Gly Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly 385 390 395 400 Ile Asn Gly Ala Ile Ala Ser Gly Glu Thr Ser Pro Gly Asp Phe 405 410 415 <210> 98 <211> 1248 <212> DNA <213> Cuphea procumbens <400> 98 atggtggctg ctgcagcaag ttctgcattc ttccctgctc cagccccggg atcctcacct 60 aaacccggga agtccggtaa ttggccatcg agcttgagcc cttccttcaa gtccaagtca 120 atcccctatg gccgatttca ggttaaggca aatgccagtg cccatcctaa ggctaacggt 180 tctgcagtaa atctaaagtc tggcagcctc aacactcagg aggacacttc gtcgtcccct 240 cctcctcggg ctttccttaa ccagttgcct gattggagta tgcttctgtc tgcaatcacg 300 actgtattcg tggcggcaga gaagcagtgg actatgcttg atcggaaatc taagaggcct 360 gacatgcttg tggactcggt tgggttgaag aatattgttc gggatgggct cgtgtccaga 420 cagagttttt tgattagatc ttatgaaata ggcgctgatc gaacagcttc tatagagaca 480 ctgatgaacc acttgcagga aacatctatc aatcattgta agagtttggg tcttctcaat 540 gacggctttg gtcgtactcc tgggatgtgt aaaaacgacc tcatttgggt gcttactaaa 600 atgcagatca tggtgaatcg ctacccagct tggggcgata ctgttgagat caatacctgg 660 ttctcccagt cggggaaaat cggtatgggt agcgattggc taataagtga ttgcaacaca 720 ggagaaattc ttataagagc aacgagcgtg tgggccatga tgaatcaaaa aacgagaaga 780 ttctcaagac ttccatacga ggttcgccag gagttaacgc ctcattttgt ggactctcct 840 catgtcattg aagacaatga tcggaaattg cataagttcg atgtgaagac tggtgattct 900 attcgcaagg gtctaactcc gaggtggaat gacttggatg tcaatcagca cgtcaacaac 960 gtgaagtaca tcgggtggat tcttgagagt actccaccag aagttctgga gacccaggag 1020 ttatgttccc ttaccctgga atacaggcag gaatgcggaa gggagagcgt gctggagtcc 1080 ctcactgctg tggacccctc tggaaagggc tttgggtccc agttccaaca ccttctgagg 1140 cttgaggatg gaggtgagat cgtgaagggg agaactgagt ggcgacccaa gactgcaggt 1200 atcaatgggg cgatagcatc cggggagacc tcacctggag acttttag 1248 <210> 99 <211> 1248 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 99 atggtggccg ccgccgcctc ctccgccttc ttccccgccc ccgcccccgg ctcctccccc 60 aagcccggca agtccggcaa ctggccctcc tccctgtccc cctccttcaa gtccaagtcc 120 atcccctacg gccgcttcca ggtgaaggcc aacgcctccg cccaccccaa ggccaacggc 180 tccgccgtga acctgaagtc cggctccctg aacacccagg aggacacctc ctcctccccc 240 cccccccgcg ccttcctgaa ccagctgccc gactggtcca tgctgctgtc cgccatcacc 300 accgtgttcg tggccgccga gaagcagtgg accatgctgg accgcaagtc caagcgcccc 360 gacatgctgg tggactccgt gggcctgaag aacatcgtgc gcgacggcct ggtgtcccgc 420 cagtccttcc tgatccgctc ctacgagatc ggcgccgacc gcaccgcctc catcgagacc 480 ctgatgaacc acctgcagga gacctccatc aaccactgca agtccctggg cctgctgaac 540 gacggcttcg gccgcacccc cggcatgtgc aagaacgacc tgatctgggt gctgaccaag 600 atgcagatca tggtgaaccg ctaccccgcc tggggcgaca ccgtggagat caacacctgg 660 ttctcccagt ccggcaagat cggcatgggc tccgactggc tgatctccga ctgcaacacc 720 ggcgagatcc tgatccgcgc cacctccgtg tgggccatga tgaaccagaa gacccgccgc 780 ttctcccgcc tgccctacga ggtgcgccag gagctgaccc cccacttcgt ggactccccc 840 cacgtgatcg aggacaacga ccgcaagctg cacaagttcg acgtgaagac cggcgactcc 900 atccgcaagg gcctgacccc ccgctggaac gacctggacg tgaaccagca cgtgaacaac 960 gtgaagtaca tcggctggat cctggagtcc accccccccg aggtgctgga gacccaggag 1020 ctgtgctccc tgaccctgga gtaccgccag gagtgcggcc gcgagtccgt gctggagtcc 1080 ctgaccgccg tggacccctc cggcaagggc ttcggctccc agttccagca cctgctgcgc 1140 ctggaggacg gcggcgagat cgtgaagggc cgcaccgagt ggcgccccaa gaccgccggc 1200 atcaacggcg ccatcgcctc cggcgagacc tcccccggcg acttctga 1248 <210> 100 <211> 410 <212> PRT <213> Cuphea procumbens <400> 100 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Ala Pro Ala Pro 1 5 10 15 Gly Ser Ser Pro Lys Pro Gly Lys Ser Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Pro Ser Phe Lys Ser Lys Ser Ile Pro Tyr Gly Arg Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Ser Val Gly 115 120 125 Leu Lys Asn Ile Val Arg Asp Gly Leu Val Ser Arg Gln Ser Phe Leu 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His Cys Lys Ser Leu 165 170 175 Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly Met Cys Lys Asn 180 185 190 Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg Tyr 195 200 205 Pro Ala Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser Gln Ser 210 215 220 Gly Lys Ile Gly Met Gly Ser Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val Arg Gln Glu Leu 260 265 270 Thr Pro His Phe Val Asp Ser Pro His Val Ile Glu Asp Asn Asp Arg 275 280 285 Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly 355 360 365 Glu Gly Gly Tyr Gly Ser Gln Phe Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Gly Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Ile Asn Gly Val Leu Pro Thr Gly Glu 405 410 <210> 101 <211> 1233 <212> DNA <213> Cuphea procumbens <400> 101 atggtggctg ctgcagcaag ttctgcattc ttccctgctc cagccccggg atcctcacct 60 aaacccggga agtccggtaa ttggccatcg agcttgagcc cttccttcaa gtccaagtca 120 atcccctatg gccgatttca ggttaaggca aatgccagtg cccatcctaa ggctaacggt 180 tctgcagtaa atctaaagtc tggcagcctc aacactcagg aggacacttc gtcgtcccct 240 cctcctcggg ctttccttaa ccagttgcct gattggagta tgcttctgtc tgcaatcacg 300 actgtattcg tggcggcaga gaagcagtgg actatgcttg atcggaaatc taagaggcct 360 gacatgcttg tggactcggt tgggttgaag aatattgttc gggatgggct cgtgtccaga 420 cagagttttt tgattagatc ttatgaaata ggcgctgatc gaacagcttc tatagagaca 480 ctgatgaacc acttgcagga aacatctatc aatcattgta agagtttggg tcttctcaat 540 gacggctttg gtcgtactcc tgggatgtgt aaaaacgacc tcatttgggt gcttactaaa 600 atgcagatca tggtgaatcg ctacccagct tggggcgata ctgttgagat caatacctgg 660 ttctcccagt cggggaaaat cggtatgggt agcgattggc taataagtga ttgcaacaca 720 ggagaaattc ttataagagc aacgagcgtg tgggccatga tgaatcaaaa aacgagaaga 780 ttctcaagac ttccatacga ggttcgccag gagttaacgc ctcattttgt ggactctcct 840 catgtcattg aagacaatga tcggaaattg cataagttcg atgtgaagac tggtgattct 900 attcgcaagg gtctaactcc gaggtggaat gacttggatg tcaatcagca cgtcaacaac 960 gtgaagtaca tcgggtggat tcttgagagt actccaccag aagttctgga gacccaggag 1020 ttatgttccc ttaccctgga atacaggcgg gaatgtggaa gggagagcgt gctggagtcc 1080 ctcactgctg tggacccctc tggagagggg ggctatggat cccagtttca gcaccttctg 1140 cggcttgagg atggaggtga gatcgtgaag gggagaactg agtggcgacc caagaatgct 1200 ggaatcaatg gggtgttacc aaccggggag tag 1233 <210> 102 <211> 1233 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 102 atggtggccg ccgccgcctc ctccgccttc ttccccgccc ccgcccccgg ctcctccccc 60 aagcccggca agtccggcaa ctggccctcc tccctgtccc cctccttcaa gtccaagtcc 120 atcccctacg gccgcttcca ggtgaaggcc aacgcctccg cccaccccaa ggccaacggc 180 tccgccgtga acctgaagtc cggctccctg aacacccagg aggacacctc ctcctccccc 240 cccccccgcg ccttcctgaa ccagctgccc gactggtcca tgctgctgtc cgccatcacc 300 accgtgttcg tggccgccga gaagcagtgg accatgctgg accgcaagtc caagcgcccc 360 gacatgctgg tggactccgt gggcctgaag aacatcgtgc gcgacggcct ggtgtcccgc 420 cagtccttcc tgatccgctc ctacgagatc ggcgccgacc gcaccgcctc catcgagacc 480 ctgatgaacc acctgcagga gacctccatc aaccactgca agtccctggg cctgctgaac 540 gacggcttcg gccgcacccc cggcatgtgc aagaacgacc tgatctgggt gctgaccaag 600 atgcagatca tggtgaaccg ctaccccgcc tggggcgaca ccgtggagat caacacctgg 660 ttctcccagt ccggcaagat cggcatgggc tccgactggc tgatctccga ctgcaacacc 720 ggcgagatcc tgatccgcgc cacctccgtg tgggccatga tgaaccagaa gacccgccgc 780 ttctcccgcc tgccctacga ggtgcgccag gagctgaccc cccacttcgt ggactccccc 840 cacgtgatcg aggacaacga ccgcaagctg cacaagttcg acgtgaagac cggcgactcc 900 atccgcaagg gcctgacccc ccgctggaac gacctggacg tgaaccagca cgtgaacaac 960 gtgaagtaca tcggctggat cctggagtcc accccccccg aggtgctgga gacccaggag 1020 ctgtgctccc tgaccctgga gtaccgccgc gagtgcggcc gcgagtccgt gctggagtcc 1080 ctgaccgccg tggacccctc cggcgagggc ggctacggct cccagttcca gcacctgctg 1140 cgcctggagg acggcggcga gatcgtgaag ggccgcaccg agtggcgccc caagaacgcc 1200 ggcatcaacg gcgtgctgcc caccggcgag tga 1233 <210> 103 <211> 395 <212> PRT <213> Cuphea ignea <400> 103 Pro Gly Thr Ser Arg Lys Thr Gly Lys Phe Gly Asn Trp Pro Ser Ser 1 5 10 15 Leu Ser Pro Ser Phe Lys Pro Lys Ser Ile Pro Asn Gly Gly Phe Gln 20 25 30 Val Lys Ala Asn Ala Arg Ala His Pro Lys Ala Asn Gly Ser Ala Val 35 40 45 Ser Leu Lys Ser Val Ser Leu Asn Thr Gln Glu Asp Thr Ser Leu Ser 50 55 60 Pro Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp Arg Met Leu 65 70 75 80 Arg Thr Ala Leu Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 85 90 95 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Ser Phe 100 105 110 Gly Leu Glu Ser Ile Val Gln Glu Gly Leu Val Phe Arg Gln Ser Phe 115 120 125 Ser Ile Arg Ser Tyr Glu Ile Gly Ile Asp Arg Thr Ala Ser Ile Glu 130 135 140 Thr Leu Met Asn His Leu Gln Glu Thr Ser Leu Asn Gln Cys Lys Ser 145 150 155 160 Ala Gly Ile Leu His Asp Gly Phe Gly Arg Thr Leu Glu Met Cys Lys 165 170 175 Arg Asp Leu Ile Trp Val Val Thr Lys Met Gln Ile Lys Val Asn Arg 180 185 190 Tyr Pro Ala Trp Gly Asp Thr Val Glu Ile Ser Thr Arg Phe Ser Arg 195 200 205 Leu Gly Lys Ile Gly Met Gly Arg Asp Trp Leu Ile Cys Asp Cys Asn 210 215 220 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ala Tyr Ala Met Met Asn 225 230 235 240 Gln Lys Thr Arg Arg Leu Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 245 250 255 Ile Ala Pro Leu Phe Val Asp Ser Asp Pro Val Ile Glu Glu Asn Asp 260 265 270 Met Lys Leu His Lys Phe Glu Val Lys Thr Gly Asp Ser Ile Cys Lys 275 280 285 Gly Leu Thr Pro Arg Trp Ser Asp Leu Asp Val Asn Gln His Val Ser 290 295 300 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val 305 310 315 320 Leu Glu Thr Gln Glu Leu Cys Ser Leu Ala Leu Glu Tyr Arg Arg Glu 325 330 335 Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ser Met Asp Pro Ser 340 345 350 Lys Val Gly Gly Trp Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 355 360 365 Gly Ala Asp Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 370 375 380 Gly Ala Asn Gly Ala Ile Ser Thr Gly Lys Thr 385 390 395 <210> 104 <211> 1188 <212> DNA <213> Cuphea ignea <400> 104 ccgggaacct cacgtaaaac cgggaagttc ggcaattggc catcaagctt gagcccttcc 60 ttcaagccca agtcaatccc caatggcgga tttcaggtta aggctaatgc cagagcccat 120 cctaaggcta acggttctgc agtaagtcta aagtctgtca gcctcaacac tcaggaggac 180 acttcgttgt cccctcctcc tcgtgctttc cttaaccagt tgcctgattg gaggatgctt 240 cggactgcac tcacgaccgt ctttgtggcg gcagagaagc agtggactat gcttgatcgg 300 aaatctaaga ggcctgacat gctcgtggac tcgtttgggt tggagagtat tgttcaagaa 360 gggctcgtgt tcagacagag cttttcgatt aggtcttatg aaataggcat tgatcgaaca 420 gcctctatag agacgctgat gaaccacttg caggaaacat ctctcaatca atgtaagagt 480 gctggtattc tccatgacgg cttcggtcgt actcttgaga tgtgtaaaag ggacctcatt 540 tgggttgtta cgaaaatgca gatcaaggtg aatcgctatc cagcttgggg cgatactgtc 600 gagatcagta cccggttctc ccggttgggg aaaatcggta tgggtcgcga ttggctaata 660 tgtgattgca acacaggaga aattcttata agagcaacga gcgcgtatgc catgatgaat 720 caaaagacga gaagactctc aaaacttcca aacgaggttc gccaggagat agcgcctctt 780 tttgtggact ctgatcctgt cattgaagaa aatgatatga aattgcataa gtttgaagtg 840 aagactggtg attccatttg caagggtcta actccgaggt ggagtgactt ggatgtcaat 900 cagcacgtaa gcaacgtgaa gtacataggg tggattctcg agagtatgcc aacagaagtt 960 ttggagacac aggagctatg ctctctcgcc cttgaatata ggcgggaatg cggaagggac 1020 agtgtgctgg agtctgtgac ctctatggat ccctcaaaag ttggaggctg gtctcagtac 1080 cagcaccttc tgcgacttga ggatggggcg gatatcgtga agggcagaac tgagtggcgg 1140 ccgaagaatg caggagctaa cggggcgata tcaacaggaa agacttga 1188 <210> 105 <211> 1188 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 105 cccggcacct cccgcaagac cggcaagttc ggcaactggc cctcctccct gtccccctcc 60 ttcaagccca agtccatccc caacggcggc ttccaggtga aggccaacgc ccgcgcccac 120 cccaaggcca acggctccgc cgtgtccctg aagtccgtgt ccctgaacac ccaggaggac 180 acctccctgt cccccccccc ccgcgccttc ctgaaccagc tgcccgactg gcgcatgctg 240 cgcaccgccc tgaccaccgt gttcgtggcc gccgagaagc agtggaccat gctggaccgc 300 aagtccaagc gccccgacat gctggtggac tccttcggcc tggagtccat cgtgcaggag 360 ggcctggtgt tccgccagtc cttctccatc cgctcctacg agatcggcat cgaccgcacc 420 gcctccatcg agaccctgat gaaccacctg caggagacct ccctgaacca gtgcaagtcc 480 gccggcatcc tgcacgacgg cttcggccgc accctggaga tgtgcaagcg cgacctgatc 540 tgggtggtga ccaagatgca gatcaaggtg aaccgctacc ccgcctgggg cgacaccgtg 600 gagatctcca cccgcttctc ccgcctgggc aagatcggca tgggccgcga ctggctgatc 660 tgcgactgca acaccggcga gatcctgatc cgcgccacct ccgcctacgc catgatgaac 720 cagaagaccc gccgcctgtc caagctgccc aacgaggtgc gccaggagat cgcccccctg 780 ttcgtggact ccgaccccgt gatcgaggag aacgacatga agctgcacaa gttcgaggtg 840 aagaccggcg actccatctg caagggcctg accccccgct ggtccgacct ggacgtgaac 900 cagcacgtgt ccaacgtgaa gtacatcggc tggatcctgg agtccatgcc caccgaggtg 960 ctggagaccc aggagctgtg ctccctggcc ctggagtacc gccgcgagtg cggccgcgac 1020 tccgtgctgg agtccgtgac ctccatggac ccctccaagg tgggcggctg gtcccagtac 1080 cagcacctgc tgcgcctgga ggacggcgcc gacatcgtga agggccgcac cgagtggcgc 1140 cccaagaacg ccggcgccaa cggcgccatc tccaccggca agacctga 1188 <210> 106 <211> 417 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 106 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Ser Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Pro Ser Phe Lys Pro Lys Ser Ile Pro Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Ser Val Gly 115 120 125 Leu Lys Arg Ile Val Gln Asp Gly Leu Val Ser Arg Gln Ser Phe Ser 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His Cys Lys Ser Leu 165 170 175 Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly Met Cys Lys Asn 180 185 190 Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg Tyr 195 200 205 Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser Gln Ser 210 215 220 Gly Lys Ile Gly Met Gly Ser Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val Arg Gln Glu Leu 260 265 270 Thr Pro His Phe Val Asp Ser Pro His Val Ile Glu Asp Asn Asp Arg 275 280 285 Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Ser Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Ile Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Val Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Met Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Glu 355 360 365 Asn Gly Gly Arg Ser Gln Tyr Lys His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser Val 405 410 415 Ser <210> 107 <211> 1254 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 107 atggtggccg ccgccgcctc ctccgccttc ttccccgtgc ccgcccccgg cacctccccc 60 aagcccggca agtccggcaa ctggccctcc tccctgtccc cctccttcaa gcccaagtcc 120 atccccaacg gcggcttcca ggtgaaggcc aacgcctccg cccaccccaa ggccaacggc 180 tccgccgtga acctgaagtc cggctccctg aacacccagg aggacacctc ctcctccccc 240 cccccccgcg ccttcctgaa ccagctgccc gactggtcca tgctgctgac cgccatcacc 300 accgtgttcg tggccgccga gaagcagtgg accatgctgg accgcaagtc caagcgcccc 360 gacatgctgg tggactccgt gggcctgaag cgcatcgtgc aggacggcct ggtgtcccgc 420 cagtccttct ccatccgctc ctacgagatc ggcgccgacc gcaccgcctc catcgagacc 480 ctgatgaacc acctgcagga gacctccatc aaccactgca agtccctggg cctgctgaac 540 gacggcttcg gccgcacccc cggcatgtgc aagaacgacc tgatctgggt gctgaccaag 600 atgcagatca tggtgaaccg ctaccccacc tggggcgaca ccgtggagat caacacctgg 660 ttctcccagt ccggcaagat cggcatgggc tccgactggc tgatctccga ctgcaacacc 720 ggcgagatcc tgatccgcgc cacctccgtg tgggccatga tgaaccagaa gacccgccgc 780 ttctcccgcc tgccctacga ggtgcgccag gagctgaccc cccacttcgt ggactccccc 840 cacgtgatcg aggacaacga ccgcaagctg cacaagttcg acgtgaagac cggcgactcc 900 atccgcaagg gcctgacccc ccgctggaac gacctggacg tgaaccagca cgtgtccaac 960 gtgaagtaca tcggctggat cctggagtcc atgcccatcg aggtgctgga gacccaggag 1020 ctgtgctccc tgaccgtgga gtaccgccgc gagtgcggca tggactccgt gctggagtcc 1080 gtgaccgcca tggacccctc cgagaacggc ggccgctccc agtacaagca cctgctgcgc 1140 ctggaggacg gcaccgacat cgtgaagggc cgcaccgagt ggcgccccaa gaacgccggc 1200 accaacggcg ccatctccac cggcaagacc tccaacggca actccgtgtc ctga 1254 <210> 108 <211> 415 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 108 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Thr Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Ser Pro Leu Lys Pro Lys Ser Val Ala Asn Gly Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly Leu 50 55 60 Lys Ser Gly Ser Leu Lys Thr Gln Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Arg Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys 355 360 365 Gly Tyr Gly Ser Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile 385 390 395 400 Asn Gly Ala Ile Ala Ser Gly Glu Thr Ser Pro Gly Asp Ser Ser 405 410 415 <210> 109 <211> 1248 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 109 atggtggcca ccgccgcctc ctccgccttc ttccccgtgc cctcccccga cacctcctcc 60 cgccccggca agctgggcaa cggctcctcc tccctgtccc ccctgaagcc caagtccgtg 120 gccaacggcg gcctgcaggt gaaggccaac gcctccgccc cccccaagat caacggctcc 180 tccgtgggcc tgaagtccgg ctccctgaag acccaggagg acaccccctc cgcccccccc 240 ccccgcacct tcatcaacca gctgcccgac tggtccatgc tgctggccgc catcaccacc 300 gtgttcctgg ccgccgagaa gcagtggatg atgctggact ggaagcccaa gcgccccgac 360 atgctggtgg accccttcgg cctgggccgc atcgtgcagg acggcctggt gttccgccag 420 aacttctcca tccgctccta cgagatcggc gccgaccgca ccgcctccat cgagaccgtg 480 atgaaccacc tgcaggagac cgccctgaac cacgtgaagt ccgccggcct gctgaacgac 540 ggcttcggcc gcacccccga gatgtacaag cgcgacctga tctgggtggt ggccaagatg 600 caggtgatgg tgaaccgcta ccccacctgg ggcgacaccg tggaggtgaa cacctgggtg 660 gccaagtccg gcaagaacgg catgcgccgc gactggctga tctccgactg caacaccggc 720 gagatcctga cccgcgcctc ctccgtgtgg gtgatgatga accagaagac ccgccgcctg 780 tccaagatcc ccgacgaggt gcgccacgag atcgagcccc acttcgtgga ctccgccccc 840 gtgatcgagg acgacgaccg caagctgccc aagctggacg agaagaccgc cgactccatc 900 cgcaagggcc tgacccccaa gtggaacgac ctggacgtga accagcacgt gaacaacgtg 960 aagtacatcg gctggatcct ggagtccacc ccccccgagg tgctggagac ccaggagctg 1020 tgctccctga ccctggagta ccgccgcgag tgcggccgcg agtccgtgct ggagtccctg 1080 accgccgtgg acccctccgg caagggctac ggctcccagt tccagcacct gctgcgcctg 1140 gaggacggcg gcgagatcgt gaagggccgc accgagtggc gccccaagac cgccggcatc 1200 aacggcgcca tcgcctccgg cgagacctcc cccggcgact cctcctga 1248 <210> 110 <211> 419 <212> PRT <213> Cuphea sp. <400> 110 Met Val Val Ala Ala Ala Thr Ser Ala Phe Phe Pro Val Pro Ala Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Ser Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Pro Thr Phe Lys Pro Lys Ser Ile Pro Asn Ala Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Ser Val Gly 115 120 125 Leu Lys Cys Ile Val Arg Asp Gly Leu Val Ser Arg Gln Ser Phe Leu 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His Cys Lys Ser Leu 165 170 175 Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly Met Cys Lys Asn 180 185 190 Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg Tyr 195 200 205 Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser Gln Ser 210 215 220 Gly Lys Ile Gly Met Ala Ser Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val Arg Gln Glu Leu 260 265 270 Thr Pro His Phe Val Asp Ser Pro His Val Ile Glu Asp Asn Asp Gln 275 280 285 Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Ser Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Ile Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Val Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Met Asp Ser Val Leu Glu Ser Val Thr Ala Val Asp Pro Ser Glu 355 360 365 Asn Gly Gly Arg Ser Gln Tyr Lys His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Ile Val Lys Ser Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Ala Ile Ser Thr Ser Thr Ala Lys Thr Ser Asn Gly Asn 405 410 415 Ser Val Ser <210> 111 <211> 419 <212> PRT <213> Cuphea sp. <400> 111 Met Val Val Ala Ala Ala Thr Ser Ala Phe Phe Pro Val Pro Ala Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Ser Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Pro Thr Phe Lys Pro Lys Ser Ile Pro Asn Ala Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Ser Val Gly 115 120 125 Leu Lys Ser Ile Val Arg Asp Gly Leu Val Ser Arg Gln Ser Phe Leu 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His Cys Lys Ser Leu 165 170 175 Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly Met Cys Lys Asn 180 185 190 Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg Tyr 195 200 205 Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser Gln Ser 210 215 220 Gly Lys Ile Gly Met Ala Ser Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val Arg Gln Glu Leu 260 265 270 Thr Pro His Phe Val Asp Ser Pro His Val Ile Glu Asp Asn Asp Gln 275 280 285 Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Ser Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Ile Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Val Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Met Asp Ser Val Leu Glu Ser Val Thr Ala Val Asp Pro Ser Glu 355 360 365 Asn Gly Gly Arg Ser Gln Tyr Lys His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Ile Val Lys Ser Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Ala Ile Ser Thr Ser Thr Ala Lys Thr Ser Asn Gly Asn 405 410 415 Ser Ala Ser <210> 112 <211> 408 <212> PRT <213> Cuphea wrightii <400> 112 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Pro Arg Thr Thr Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser 20 25 30 Leu Ser Pro Pro Phe Lys Pro Lys Ser Asn Pro Asn Gly Arg Phe Gln 35 40 45 Val Lys Ala Asn Val Ser Pro His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Leu Glu Asp Pro Pro Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Arg Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Phe Thr 100 105 110 Arg Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Trp Phe 115 120 125 Gly Ser Glu Thr Ile Val Gln Asp Gly Leu Val Phe Arg Glu Arg Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn His Leu Gln Asp Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Val Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Ser Glu Met Cys Thr 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Val Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Val Arg Ala Thr Ser Ala Trp Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Leu Pro Cys Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Cys Lys 290 295 300 Gly Leu Thr Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val 325 330 335 Leu Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Glu Ser Val Val Glu Ser Val Thr Ser Met Asn Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Ala Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Arg Ala Ile Ser Thr 405 <210> 113 <211> 408 <212> PRT <213> Cuphea wrightii <400> 113 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Pro Arg Thr Thr Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser 20 25 30 Leu Ser Pro Pro Phe Lys Pro Lys Ser Asn Pro Asn Gly Arg Phe Gln 35 40 45 Val Lys Ala Asn Val Ser Pro His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Leu Glu Asp Pro Pro Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Arg Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Phe Thr 100 105 110 Arg Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Trp Phe 115 120 125 Gly Ser Glu Thr Ile Val Gln Asp Gly Leu Val Phe Arg Glu Arg Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn His Leu Gln Asp Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Val Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Ser Glu Met Cys Thr 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Val Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Val Arg Ala Thr Ser Ala Trp Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Leu Pro Cys Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Cys Lys 290 295 300 Gly Leu Thr Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val 325 330 335 Leu Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Glu Ser Val Val Glu Ser Val Thr Ser Met Asn Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Ala Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Arg Ala Ile Ser Thr 405 <210> 114 <211> 354 <212> PRT <213> Cuphea wrightii <400> 114 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Pro Arg Thr Thr Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser 20 25 30 Leu Ser Pro Pro Phe Lys Pro Lys Ser Asn Pro Asn Gly Arg Phe Gln 35 40 45 Val Lys Ala Asn Val Ser Pro His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Leu Glu Asp Leu Pro Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Arg Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Phe Thr 100 105 110 Arg Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Trp Phe 115 120 125 Gly Ser Glu Thr Ile Val Gln Asp Gly Leu Val Phe Arg Glu Arg Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn His Leu Gln Asp Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Val Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Ser Glu Met Cys Thr 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Val Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Val Arg Ala Thr Ser Ala Trp Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Leu Pro Cys Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Cys Lys 290 295 300 Gly Leu Thr Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Lys Phe Trp Arg Pro Arg 325 330 335 Ser Tyr Ala Leu Ser Pro Leu Asn Ile Gly Gly Asn Val Glu Gly Lys 340 345 350 Val Trp <210> 115 <211> 354 <212> PRT <213> Cuphea wrightii <400> 115 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Pro Arg Thr Thr Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser 20 25 30 Leu Ser Pro Pro Phe Lys Pro Lys Ser Asn Pro Asn Gly Arg Phe Gln 35 40 45 Val Lys Ala Asn Val Ser Pro His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Leu Glu Asp Leu Pro Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Arg Thr Ala Ile Thr Thr Val Phe Val Ala Thr Glu Lys Gln Phe Thr 100 105 110 Arg Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Trp Phe 115 120 125 Gly Ser Glu Thr Ile Val Gln Asp Gly Leu Val Phe Arg Glu Arg Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn His Leu Gln Asp Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Val Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Ser Glu Met Cys Thr 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Val Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Val Arg Ala Thr Ser Ala Trp Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Leu Pro Cys Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Cys Lys 290 295 300 Gly Leu Thr Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Lys Phe Trp Arg Pro Arg 325 330 335 Ser Tyr Ala Leu Ser Pro Leu Asn Ile Gly Gly Asn Val Glu Gly Lys 340 345 350 Val Trp <210> 116 <211> 416 <212> PRT <213> Cuphea wrightii <400> 116 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Ala 1 5 10 15 Asp Thr Ser Ser Ser Arg Pro Gly Lys Leu Gly Ser Gly Pro Ser Ser 20 25 30 Leu Ser Pro Leu Lys Pro Lys Ser Ile Pro Asn Gly Gly Leu Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly 50 55 60 Leu Lys Ser Gly Gly Phe Lys Thr Gln Glu Asp Ser Pro Ser Ala Pro 65 70 75 80 Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ala Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met 100 105 110 Leu Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly 115 120 125 Leu Gly Ser Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Val Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ile Ala 165 170 175 Gly Leu Ser Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg 180 185 190 Asp Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr 195 200 205 Pro Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser 210 215 220 Gly Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg Asn Glu Ile 260 265 270 Glu Pro His Phe Val Asp Ser Ala Pro Val Val Glu Asp Asp Asp Arg 275 280 285 Lys Leu Pro Lys Leu Asp Glu Asn Thr Ala Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Ala 355 360 365 Glu Gly Tyr Ala Ser Arg Phe Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Gly Glu Ile Val Lys Ala Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Ile Asn Gly Val Val Pro Ser Glu Glu Ser Ser Pro Gly Asp Phe Phe 405 410 415 <210> 117 <211> 416 <212> PRT <213> Cuphea wrightii <400> 117 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Ala 1 5 10 15 Asp Thr Ser Ser Ser Arg Pro Gly Lys Leu Gly Ser Gly Pro Ser Ser 20 25 30 Leu Ser Pro Leu Lys Pro Lys Ser Ile Pro Asn Gly Gly Leu Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly 50 55 60 Leu Lys Ser Gly Gly Phe Lys Thr Gln Glu Asp Ser Pro Ser Ala Pro 65 70 75 80 Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ala Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met 100 105 110 Leu Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly 115 120 125 Leu Gly Ser Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Val Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ile Ala 165 170 175 Gly Leu Ser Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg 180 185 190 Asp Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr 195 200 205 Pro Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser 210 215 220 Gly Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg Asn Glu Ile 260 265 270 Glu Pro His Phe Val Asp Ser Ala Pro Val Val Glu Asp Asp Asp Arg 275 280 285 Lys Leu Pro Lys Leu Asp Glu Asn Thr Ala Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Ala 355 360 365 Glu Gly Tyr Ala Ser Arg Phe Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Gly Glu Ile Val Lys Ala Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Ile Asn Trp Val Val Pro Ser Glu Glu Ser Ser Pro Gly Asp Phe Phe 405 410 415 <210> 118 <211> 416 <212> PRT <213> Cuphea wrightii <400> 118 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Ala 1 5 10 15 Asp Thr Ser Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Pro Ser Ser 20 25 30 Leu Ser Pro Leu Lys Pro Lys Ser Ile Pro Asn Gly Gly Leu Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly 50 55 60 Leu Lys Ser Gly Ser Phe Lys Thr Gln Glu Asp Ala Pro Ser Ala Pro 65 70 75 80 Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ala Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met 100 105 110 Leu Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly 115 120 125 Leu Gly Ser Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Val Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ile Ala 165 170 175 Gly Leu Ser Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg 180 185 190 Asp Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr 195 200 205 Pro Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser 210 215 220 Gly Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg Asn Glu Ile 260 265 270 Glu Pro His Phe Val Asp Ser Ala Pro Val Val Glu Asp Asp Asp Arg 275 280 285 Lys Leu Pro Lys Leu Asp Glu Asn Thr Ala Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Ala 355 360 365 Glu Gly Tyr Ala Ser Arg Phe Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Gly Glu Ile Val Lys Ala Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Ile Asn Gly Val Val Pro Ser Glu Glu Ser Ser Pro Gly Asp Phe Phe 405 410 415 <210> 119 <211> 416 <212> PRT <213> Cuphea wrightii <400> 119 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Ala 1 5 10 15 Asp Thr Ser Ser Ser Arg Pro Gly Lys Leu Gly Ser Gly Pro Ser Ser 20 25 30 Leu Ser Pro Leu Lys Pro Lys Ser Ile Pro Asn Gly Gly Leu Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly 50 55 60 Leu Lys Ser Gly Gly Phe Lys Thr Gln Glu Asp Ser Pro Ser Ala Pro 65 70 75 80 Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ala Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met 100 105 110 Leu Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly 115 120 125 Leu Gly Ser Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Val Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ile Ala 165 170 175 Gly Leu Ser Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg 180 185 190 Asp Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr 195 200 205 Pro Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser 210 215 220 Gly Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg Asn Glu Ile 260 265 270 Glu Pro His Phe Val Asp Ser Ala Pro Val Val Glu Asp Asp Asp Arg 275 280 285 Lys Leu Pro Lys Leu Asp Glu Asn Thr Ala Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Ala 355 360 365 Glu Gly Tyr Val Ser Arg Phe Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Gly Glu Ile Val Lys Ala Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Ile Asn Gly Val Val Pro Ser Glu Glu Ser Ser Pro Gly Asp Phe Phe 405 410 415 <210> 120 <211> 417 <212> PRT <213> Cuphea wrightii <400> 120 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Ala 1 5 10 15 Asp Thr Ser Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Pro Ser Ser 20 25 30 Leu Ser Pro Leu Lys Pro Lys Ser Ile Pro Asn Gly Gly Leu Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly 50 55 60 Leu Lys Ser Gly Ser Phe Lys Thr Gln Glu Asp Ala Pro Ser Ala Pro 65 70 75 80 Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ala Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met 100 105 110 Leu Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly 115 120 125 Leu Gly Ser Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Val Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ile Ala 165 170 175 Gly Leu Ser Ser Asp Gly Phe Gly Arg Thr Pro Ala Met Ser Lys Arg 180 185 190 Asp Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr 195 200 205 Pro Ala Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser 210 215 220 Gly Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg Asn Glu Ile 260 265 270 Glu Pro His Phe Val Asp Ser Ala Pro Val Val Glu Asp Asp Asp Arg 275 280 285 Lys Leu Pro Lys Leu Asp Glu Asn Thr Ala Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Ala Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly 355 360 365 Glu Gly Asp Gly Ser Lys Phe Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Gly Glu Ile Val Lys Ala Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Ile Asn Gly Val Val Pro Ser Glu Glu Ser Ser Pro Gly Gly Asp Phe 405 410 415 Phe <210> 121 <211> 417 <212> PRT <213> Cuphea wrightii <400> 121 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Ala 1 5 10 15 Asp Thr Ser Ser Ser Arg Pro Gly Lys Leu Gly Ser Gly Pro Ser Ser 20 25 30 Leu Ser Pro Leu Lys Pro Lys Ser Ile Pro Asn Gly Gly Leu Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly 50 55 60 Leu Lys Ser Gly Ser Phe Lys Thr Gln Glu Asp Ala Pro Ser Ala Pro 65 70 75 80 Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ala Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met 100 105 110 Leu Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly 115 120 125 Leu Gly Ser Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Val Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ile Ala 165 170 175 Gly Leu Ser Ser Asp Gly Phe Gly Arg Thr Pro Ala Met Ser Lys Arg 180 185 190 Asp Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr 195 200 205 Pro Ala Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser 210 215 220 Gly Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg Asn Glu Ile 260 265 270 Glu Pro His Phe Val Asp Ser Ala Pro Val Val Glu Asp Asp Asp Arg 275 280 285 Lys Leu Pro Lys Leu Asp Glu Asn Thr Ala Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Ala Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly 355 360 365 Glu Gly Asp Gly Ser Lys Phe Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Gly Glu Ile Val Lys Ala Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Ile Asn Gly Val Val Pro Ser Glu Glu Ser Ser Pro Gly Gly Asp Phe 405 410 415 Phe <210> 122 <211> 413 <212> PRT <213> Cuphea wrightii <400> 122 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Pro 1 5 10 15 Gly Thr Pro Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Pro Asp Asn Gly Gly Phe His Val Lys Ala Asn 35 40 45 Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn Leu Lys Ser 50 55 60 Gly Ser Leu Glu Thr Pro Pro Arg Ser Phe Ile Asn Gln Leu Pro Asp 65 70 75 80 Leu Ser Val Leu Leu Ser Lys Ile Thr Thr Val Phe Gly Ala Ala Glu 85 90 95 Lys Gln Trp Lys Arg Pro Gly Met Leu Val Glu Pro Phe Gly Val Asp 100 105 110 Arg Ile Phe Gln Asp Gly Val Phe Phe Arg Gln Ser Phe Ser Ile Arg 115 120 125 Ser Tyr Glu Ile Gly Val Asp Arg Thr Ala Ser Ile Glu Thr Leu Met 130 135 140 Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser Ile Gly Leu 145 150 155 160 Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu 165 170 175 Ile Trp Val Val Thr Lys Ile Gln Val Glu Val Asn Arg Tyr Pro Thr 180 185 190 Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu Ser Gly Lys 195 200 205 Asn Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Arg Thr Gly Glu 210 215 220 Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln Asn Thr 225 230 235 240 Arg Arg Leu Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro 245 250 255 His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Gln Lys Leu Gln 260 265 270 Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Arg Asp Gly Leu Thr Pro 275 280 285 Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val Lys Tyr 290 295 300 Ile Gly Trp Ile Leu Lys Ser Val Pro Ile Glu Val Phe Glu Thr Gln 305 310 315 320 Glu Leu Cys Gly Val Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg Asp 325 330 335 Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ala Lys Glu Gly Asp 340 345 350 Arg Cys Val Tyr Gln His Leu Leu Arg Leu Glu Asp Gly Ala Asp Ile 355 360 365 Thr Ile Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn Gly 370 375 380 Ala Met Ser Ser Gly Lys Thr Ser Asn Gly Asn Cys Leu Ile Glu Gly 385 390 395 400 Arg Gly Trp Gln Pro Phe Arg Val Val Arg Leu Ile Phe 405 410 <210> 123 <211> 413 <212> PRT <213> Cuphea wrightii <400> 123 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Pro 1 5 10 15 Gly Thr Pro Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Pro Asp Asn Gly Gly Phe His Val Lys Ala Asn 35 40 45 Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn Leu Lys Ser 50 55 60 Gly Ser Leu Glu Thr Pro Pro Arg Ser Phe Ile Asn Gln Leu Pro Asp 65 70 75 80 Leu Ser Val Leu Leu Ser Lys Ile Thr Thr Val Phe Gly Ala Ala Glu 85 90 95 Lys Gln Trp Lys Arg Pro Gly Met Leu Val Glu Pro Phe Gly Val Asp 100 105 110 Arg Ile Phe Gln Asp Gly Phe Phe Phe Arg Gln Ser Phe Ser Ile Arg 115 120 125 Ser Tyr Glu Ile Gly Val Asp Arg Thr Ala Ser Ile Glu Thr Leu Met 130 135 140 Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser Ile Gly Leu 145 150 155 160 Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu 165 170 175 Ile Trp Val Val Thr Lys Ile Gln Val Glu Val Asn Arg Tyr Pro Thr 180 185 190 Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu Ser Gly Lys 195 200 205 Asn Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Arg Thr Gly Glu 210 215 220 Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln Asn Thr 225 230 235 240 Arg Arg Leu Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro 245 250 255 His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Gln Lys Leu Gln 260 265 270 Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Arg Asp Gly Leu Thr Pro 275 280 285 Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val Lys Tyr 290 295 300 Ile Gly Trp Ile Leu Lys Ser Val Pro Ile Glu Val Phe Glu Thr Gln 305 310 315 320 Glu Leu Cys Gly Val Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg Asp 325 330 335 Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ala Lys Glu Gly Asp 340 345 350 Arg Cys Val Tyr Gln His Leu Leu Arg Leu Glu Asp Gly Ala Asp Ile 355 360 365 Thr Ile Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn Gly 370 375 380 Ala Met Ser Ser Gly Lys Thr Ser Asn Gly Asn Cys Leu Ile Glu Gly 385 390 395 400 Arg Gly Trp Gln Pro Phe Arg Val Val Arg Leu Ile Phe 405 410 <210> 124 <211> 413 <212> PRT <213> Cuphea wrightii <400> 124 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Pro 1 5 10 15 Gly Thr Pro Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Pro Asp Asn Gly Gly Phe His Val Lys Ala Asn 35 40 45 Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn Leu Lys Ser 50 55 60 Gly Ser Leu Glu Thr Pro Pro Arg Ser Phe Ile Asn Gln Leu Pro Asp 65 70 75 80 Leu Ser Val Leu Leu Ser Lys Ile Thr Thr Val Phe Gly Ala Ala Glu 85 90 95 Lys Gln Trp Lys Arg Pro Gly Met Leu Val Glu Pro Phe Gly Val Asp 100 105 110 Arg Ile Phe Gln Asp Gly Val Phe Phe Arg Gln Ser Phe Ser Ile Arg 115 120 125 Ser Tyr Glu Ile Gly Val Asp Arg Thr Ala Ser Ile Glu Thr Leu Met 130 135 140 Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser Ile Gly Leu 145 150 155 160 Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu 165 170 175 Ile Trp Val Val Thr Lys Ile Gln Val Glu Val Asn Arg Tyr Pro Thr 180 185 190 Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu Ser Gly Lys 195 200 205 Asn Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Arg Thr Gly Glu 210 215 220 Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln Asn Thr 225 230 235 240 Arg Arg Leu Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro 245 250 255 His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Gln Lys Leu Gln 260 265 270 Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Arg Asp Gly Leu Thr Pro 275 280 285 Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val Lys Tyr 290 295 300 Ile Gly Trp Ile Leu Lys Ser Val Pro Ile Glu Val Phe Glu Thr Gln 305 310 315 320 Glu Leu Cys Gly Val Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg Asp 325 330 335 Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ala Lys Glu Gly Asp 340 345 350 Arg Cys Val Tyr Gln His Leu Leu Trp Leu Glu Asp Gly Ala Asp Ile 355 360 365 Thr Ile Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn Gly 370 375 380 Ala Met Ser Ser Gly Lys Thr Ser Asn Gly Asn Cys Leu Ile Glu Gly 385 390 395 400 Arg Gly Trp Gln Pro Phe Arg Val Val Arg Leu Ile Phe 405 410 <210> 125 <211> 413 <212> PRT <213> Cuphea wrightii <400> 125 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Pro 1 5 10 15 Gly Thr Pro Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Pro Asp Asn Gly Gly Phe His Val Lys Ala Asn 35 40 45 Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn Leu Lys Ser 50 55 60 Gly Ser Leu Glu Thr Pro Pro Arg Ser Phe Ile Asn Gln Leu Pro Asp 65 70 75 80 Leu Ser Val Leu Leu Ser Lys Ile Thr Thr Val Phe Gly Ala Ala Glu 85 90 95 Lys Gln Trp Lys Arg Pro Gly Met Leu Val Glu Pro Phe Gly Val Asp 100 105 110 Arg Ile Phe Gln Asp Gly Val Phe Phe Arg Gln Ser Phe Ser Ile Arg 115 120 125 Ser Tyr Glu Ile Gly Val Asp Arg Thr Ala Ser Ile Glu Thr Leu Met 130 135 140 Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser Ile Gly Leu 145 150 155 160 Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu 165 170 175 Ile Trp Val Val Thr Lys Ile Gln Val Glu Val Asn Arg Tyr Pro Ile 180 185 190 Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu Ser Gly Lys 195 200 205 Asn Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Arg Thr Gly Glu 210 215 220 Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln Asn Thr 225 230 235 240 Arg Arg Leu Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro 245 250 255 His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Gln Lys Leu Gln 260 265 270 Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Arg Asp Gly Leu Thr Pro 275 280 285 Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val Lys Tyr 290 295 300 Ile Gly Trp Ile Leu Lys Ser Val Pro Ile Glu Val Phe Glu Thr Gln 305 310 315 320 Glu Leu Cys Gly Val Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg Asp 325 330 335 Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ala Lys Glu Gly Asp 340 345 350 Arg Cys Val Tyr Gln His Leu Leu Arg Leu Glu Asp Gly Ala Asp Ile 355 360 365 Thr Ile Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn Gly 370 375 380 Ala Met Ser Ser Gly Lys Thr Ser Asn Gly Asn Cys Leu Ile Glu Gly 385 390 395 400 Met Gly Trp Gln Pro Phe Arg Val Val Arg Leu Ile Phe 405 410 <210> 126 <211> 409 <212> PRT <213> Cuphea wrightii <400> 126 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Arg Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Pro Glu Thr Asn His Asn Gly Gly Phe His Ile 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Leu Asn 50 55 60 Leu Lys Ser Gly Ser Leu Glu Thr Gln Glu Asp Thr Ser Leu Ser Ser 65 70 75 80 Pro Pro Arg Thr Phe Ile Lys Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ser Lys Ile Thr Thr Val Phe Gly Ala Ala Glu Lys Gln Leu Lys Arg 100 105 110 Pro Gly Met Leu Val Glu Pro Phe Gly Val Asp Arg Ile Phe Gln Asp 115 120 125 Gly Val Phe Phe Arg Gln Ser Phe Ser Ile Arg Ser Tyr Glu Ile Gly 130 135 140 Ala Asp Arg Thr Ala Ser Ile Glu Thr Leu Met Asn Ile Phe Gln Glu 145 150 155 160 Thr Ser Leu Asn His Cys Lys Ser Ile Gly Leu Leu Asn Asp Gly Phe 165 170 175 Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu Ile Trp Val Val Thr 180 185 190 Lys Ile Gln Val Glu Val Asn Arg Tyr Pro Thr Trp Gly Asp Thr Ile 195 200 205 Glu Val Asn Thr Trp Val Ser Glu Ser Gly Lys Asn Gly Met Gly Arg 210 215 220 Asp Trp Leu Ile Ser Asp Cys Arg Thr Gly Glu Ile Leu Ile Arg Ala 225 230 235 240 Thr Ser Val Trp Ala Met Met Asn Gln Asn Thr Arg Arg Leu Ser Lys 245 250 255 Phe Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro His Phe Val Asp Ser 260 265 270 Ala Pro Val Ile Glu Asp Asp Arg Lys Leu Tyr Lys Leu Asn Val Lys 275 280 285 Thr Gly Asp Ser Ile Arg Asp Gly Leu Thr Pro Arg Trp Asn Asp Leu 290 295 300 Asp Val Asn Gln His Val Asn Asn Val Lys Phe Ile Gly Trp Ile Leu 305 310 315 320 Lys Ser Val Pro Thr Lys Val Phe Glu Thr Gln Glu Leu Cys Gly Val 325 330 335 Thr Leu Glu Tyr Arg Arg Glu Cys Gly Lys Asp Ser Val Leu Glu Ser 340 345 350 Val Thr Ala Met Asp Pro Ala Lys Glu Gly Asp Arg Ser Val Tyr Gln 355 360 365 His Leu Leu Arg Leu Glu Asp Gly Ala Asp Ile Thr Ile Gly Arg Thr 370 375 380 Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn Glu Ala Ile Ser Ser Gly 385 390 395 400 Lys Thr Ser Asn Gly Asn Ser Ala Ser 405 <210> 127 <211> 409 <212> PRT <213> Cuphea wrightii <400> 127 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Arg Asn Trp Pro Leu Ser Leu 20 25 30 Ser Val Pro Phe Lys Pro Glu Thr Asn His Asn Gly Gly Phe His Ile 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Leu Asn 50 55 60 Leu Lys Ser Gly Ser Leu Glu Thr Gln Glu Asp Thr Ser Leu Ser Ser 65 70 75 80 Pro Pro Arg Thr Phe Ile Lys Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ser Lys Ile Thr Thr Val Phe Gly Ala Ala Glu Lys Gln Leu Lys Arg 100 105 110 Pro Gly Met Leu Val Glu Pro Phe Gly Val Asp Arg Ile Phe Gln Asp 115 120 125 Gly Val Phe Phe Arg Gln Ser Phe Ser Ile Arg Ser Tyr Glu Ile Gly 130 135 140 Ala Asp Arg Thr Ala Ser Ile Glu Thr Leu Met Asn Ile Phe Gln Glu 145 150 155 160 Thr Ser Leu Asn His Cys Lys Ser Ile Gly Leu Leu Asn Asp Gly Phe 165 170 175 Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu Ile Trp Val Val Thr 180 185 190 Lys Ile Gln Val Glu Val Asn Arg Tyr Pro Thr Trp Gly Asp Thr Ile 195 200 205 Glu Val Asn Thr Trp Val Ser Glu Ser Gly Lys Asn Gly Met Gly Arg 210 215 220 Asp Trp Leu Ile Ser Asp Cys Arg Thr Gly Glu Ile Leu Ile Arg Ala 225 230 235 240 Thr Ser Val Trp Ala Met Met Asn Gln Asn Thr Arg Arg Leu Ser Lys 245 250 255 Phe Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro His Phe Val Asp Ser 260 265 270 Ala Pro Val Ile Glu Asp Asp Arg Lys Leu Tyr Lys Leu Asn Val Lys 275 280 285 Thr Gly Asp Ser Ile Arg Asp Gly Leu Thr Pro Arg Trp Asn Asp Leu 290 295 300 Asp Val Asn Gln His Val Asn Asn Val Lys Phe Ile Gly Trp Ile Leu 305 310 315 320 Lys Ser Val Pro Thr Lys Val Phe Glu Thr Gln Glu Leu Cys Gly Val 325 330 335 Thr Leu Glu Tyr Arg Arg Glu Cys Gly Lys Asp Ser Val Leu Glu Ser 340 345 350 Val Thr Ala Met Asp Pro Ala Lys Glu Gly Asp Arg Ser Val Tyr Gln 355 360 365 His Leu Leu Arg Leu Glu Asp Gly Ala Asp Ile Thr Ile Gly Arg Thr 370 375 380 Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn Glu Ala Ile Ser Ser Gly 385 390 395 400 Lys Thr Ser Asn Gly Asn Ser Ala Ser 405 <210> 128 <211> 357 <212> PRT <213> Cinnamomum camphora <400> 128 Met Val Thr Thr Ser Leu Ala Ser Ala Tyr Phe Ser Met Lys Ala Val 1 5 10 15 Met Leu Ala Pro Asp Gly Arg Gly Ile Lys Pro Arg Ser Ser Gly Leu 20 25 30 Gln Val Arg Ala Gly Asn Glu Arg Asn Ser Cys Lys Val Ile Asn Gly 35 40 45 Thr Lys Val Lys Asp Thr Glu Gly Leu Lys Gly Cys Ser Thr Leu Gln 50 55 60 Gly Gln Ser Met Leu Asp Asp His Phe Gly Leu His Gly Leu Val Phe 65 70 75 80 Arg Arg Thr Phe Ala Ile Arg Cys Tyr Glu Val Gly Pro Asp Arg Ser 85 90 95 Thr Ser Ile Met Ala Val Met Asn His Leu Gln Glu Ala Ala Arg Asn 100 105 110 His Ala Glu Ser Leu Gly Leu Leu Gly Asp Gly Phe Gly Glu Thr Leu 115 120 125 Glu Met Ser Lys Arg Asp Leu Ile Trp Val Val Arg Arg Thr His Val 130 135 140 Ala Val Glu Arg Tyr Pro Ala Trp Gly Asp Thr Val Glu Val Glu Ala 145 150 155 160 Trp Val Gly Ala Ser Gly Asn Thr Gly Met Arg Arg Asp Phe Leu Val 165 170 175 Arg Asp Cys Lys Thr Gly His Ile Leu Thr Arg Cys Thr Ser Val Ser 180 185 190 Val Met Met Asn Met Arg Thr Arg Arg Leu Ser Lys Ile Pro Gln Glu 195 200 205 Val Arg Ala Glu Ile Asp Pro Leu Phe Ile Glu Lys Val Ala Val Lys 210 215 220 Glu Gly Glu Ile Lys Lys Leu Gln Lys Leu Asn Asp Ser Thr Ala Asp 225 230 235 240 Tyr Ile Gln Gly Gly Trp Thr Pro Arg Trp Asn Asp Leu Asp Val Asn 245 250 255 Gln His Val Asn Asn Ile Ile Tyr Val Gly Trp Ile Phe Lys Ser Val 260 265 270 Pro Asp Ser Ile Ser Glu Asn His His Leu Ser Ser Ile Thr Leu Glu 275 280 285 Tyr Arg Arg Glu Cys Ile Arg Gly Asn Lys Leu Gln Ser Leu Thr Thr 290 295 300 Val Cys Gly Gly Ser Ser Glu Ala Gly Ile Ile Cys Glu His Leu Leu 305 310 315 320 Gln Leu Glu Asp Gly Ser Glu Val Leu Arg Ala Arg Thr Glu Trp Arg 325 330 335 Pro Lys His Thr Asp Ser Phe Gln Gly Ile Ser Glu Arg Phe Pro Gln 340 345 350 Gln Glu Pro His Lys 355 <210> 129 <211> 419 <212> PRT <213> Cinnamomum camphora <400> 129 Met Val Ala Thr Ala Ala Ala Ser Ala Phe Phe Pro Val Gly Ala Pro 1 5 10 15 Ala Thr Ser Ser Ala Thr Ser Ala Lys Ala Ser Met Met Pro Asp Asn 20 25 30 Leu Asp Ala Arg Gly Ile Lys Pro Lys Pro Ala Ser Ser Ser Gly Leu 35 40 45 Gln Val Lys Ala Asn Ala His Ala Ser Pro Lys Ile Asn Gly Ser Lys 50 55 60 Val Ser Thr Asp Thr Leu Lys Gly Glu Asp Thr Leu Thr Ser Ser Pro 65 70 75 80 Ala Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Phe Leu 85 90 95 Ala Ala Ile Thr Thr Ile Phe Leu Ala Ala Glu Lys Gln Trp Thr Asn 100 105 110 Leu Asp Trp Lys Pro Arg Arg Pro Asp Met Leu Ala Asp Pro Phe Gly 115 120 125 Ile Gly Arg Phe Met Gln Asp Gly Leu Ile Phe Arg Gln His Phe Ala 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Arg Ser Ala 165 170 175 Gly Leu Leu Gly Asp Gly Phe Gly Ala Thr Pro Glu Met Ser Arg Arg 180 185 190 Asp Leu Ile Trp Val Val Thr Arg Met Gln Val Leu Val Asp Arg Tyr 195 200 205 Pro Ala Trp Gly Asp Ile Val Glu Val Glu Thr Trp Val Gly Ala Ser 210 215 220 Gly Lys Asn Gly Met Arg Arg Asp Trp Leu Val Arg Asp Ser Gln Thr 225 230 235 240 Gly Glu Ile Leu Thr Arg Ala Thr Ser Val Trp Val Met Met Asn Lys 245 250 255 Arg Thr Arg Arg Leu Ser Lys Leu Pro Glu Glu Val Arg Gly Glu Ile 260 265 270 Gly Pro Tyr Phe Ile Glu Asp Val Ala Ile Ile Glu Glu Asp Asn Arg 275 280 285 Lys Leu Gln Lys Leu Asn Glu Asn Thr Ala Asp Asn Val Arg Arg Gly 290 295 300 Leu Thr Pro Arg Trp Ser Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Ala Pro Gly Ser Ile Leu 325 330 335 Glu Ser His Glu Leu Ser Cys Met Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Lys Asp Ser Val Leu Gln Ser Met Thr Ala Val Ser Gly Gly Gly 355 360 365 Ser Ala Ala Gly Gly Ser Pro Glu Ser Ser Val Glu Cys Asp His Leu 370 375 380 Leu Gln Leu Glu Ser Gly Pro Glu Val Val Arg Gly Arg Thr Glu Trp 385 390 395 400 Arg Pro Lys Ser Ala Asn Asn Ser Arg Ser Ile Leu Glu Met Pro Ala 405 410 415 Glu Ser Leu <210> 130 <211> 419 <212> PRT <213> Cinnamomum camphora <400> 130 Met Val Ala Thr Ala Ala Ala Ser Ala Phe Phe Pro Val Gly Ala Pro 1 5 10 15 Ala Thr Ser Ser Ala Thr Ser Ala Lys Ala Ser Met Met Pro Asp Asn 20 25 30 Leu Asp Ala Arg Gly Ile Lys Pro Lys Leu Ala Ser Ser Ser Gly Leu 35 40 45 Gln Val Lys Ala Asn Ala His Ala Ser Pro Lys Ile Asn Gly Ser Lys 50 55 60 Val Ser Thr Asp Thr Leu Lys Gly Glu Asp Thr Leu Thr Ser Ser Pro 65 70 75 80 Ala Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Phe Leu 85 90 95 Ala Ala Ile Thr Thr Ile Phe Leu Ala Ala Glu Lys Gln Trp Thr Asn 100 105 110 Leu Asp Trp Lys Pro Arg Arg Pro Asp Met Leu Ala Asp Pro Phe Gly 115 120 125 Ile Gly Arg Phe Met Gln Asp Gly Leu Ile Phe Arg Gln His Phe Ala 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Arg Ser Ala 165 170 175 Gly Leu Leu Gly Asp Gly Phe Gly Ala Thr Pro Glu Met Ser Arg Arg 180 185 190 Asp Leu Ile Trp Val Val Thr Arg Met Gln Val Leu Val Asp Arg Tyr 195 200 205 Pro Ala Trp Gly Asp Ile Val Glu Val Glu Thr Trp Val Gly Ala Ser 210 215 220 Gly Lys Asn Gly Met Arg Arg Asp Trp Leu Val Arg Asp Ser Gln Thr 225 230 235 240 Gly Glu Ile Leu Thr Arg Ala Thr Ser Val Trp Val Met Met Asn Lys 245 250 255 Arg Thr Arg Arg Leu Ser Lys Leu Pro Glu Glu Val Arg Gly Glu Ile 260 265 270 Gly Pro Tyr Phe Ile Glu Asp Val Ala Ile Ile Glu Glu Asp Asn Arg 275 280 285 Lys Leu Gln Lys Leu Asn Glu Asn Thr Ala Asp Asn Val Arg Arg Gly 290 295 300 Leu Thr Pro Arg Trp Ser Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Ala Pro Gly Ser Ile Leu 325 330 335 Glu Ser His Glu Leu Ser Cys Met Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Lys Asp Ser Val Leu Gln Ser Met Thr Ala Val Ser Gly Gly Gly 355 360 365 Ser Ala Ala Gly Gly Ser Pro Glu Ser Ser Val Glu Cys Asp His Leu 370 375 380 Leu Gln Leu Glu Ser Gly Pro Glu Val Val Arg Gly Arg Thr Glu Trp 385 390 395 400 Arg Pro Lys Ser Ala Asn Asn Ser Arg Ser Ile Leu Glu Met Pro Ala 405 410 415 Glu Ser Leu <210> 131 <211> 419 <212> PRT <213> Cinnamomum camphora <400> 131 Met Val Ala Thr Ala Ala Ala Ser Ala Phe Phe Pro Val Gly Ala Pro 1 5 10 15 Ala Thr Ser Ser Ala Thr Ser Ala Lys Ala Ser Met Met Pro Asp Asn 20 25 30 Leu Asp Ala Arg Gly Ile Lys Pro Lys Pro Ala Ser Ser Ser Gly Leu 35 40 45 Gln Val Lys Ala Asn Ala His Ala Ser Pro Lys Ile Asn Gly Ser Lys 50 55 60 Val Ser Thr Asp Thr Leu Lys Gly Glu Asp Thr Leu Thr Ser Ser Pro 65 70 75 80 Ala Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Phe Leu 85 90 95 Ala Ala Ile Thr Thr Ile Phe Leu Ala Ala Glu Lys Gln Trp Thr Asn 100 105 110 Leu Asp Trp Lys Pro Arg Arg Pro Asp Met Leu Ala Asp Pro Phe Gly 115 120 125 Ile Gly Arg Phe Met Gln Asp Gly Leu Ile Phe Arg Gln His Phe Ala 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Arg Ser Ala 165 170 175 Gly Leu Leu Gly Asp Gly Phe Gly Ala Thr Pro Glu Met Ser Arg Arg 180 185 190 Asp Leu Ile Trp Val Val Thr Arg Met Gln Val Leu Val Asp Arg Tyr 195 200 205 Pro Ala Trp Gly Asp Ile Val Glu Val Glu Thr Trp Val Gly Ala Ser 210 215 220 Gly Lys Asn Gly Met Arg Arg Asp Trp Leu Val Arg Asp Ser Gln Thr 225 230 235 240 Gly Glu Ile Leu Thr Arg Ala Thr Ser Val Trp Val Met Met Asn Lys 245 250 255 Arg Thr Arg Arg Leu Ser Lys Leu Pro Glu Glu Val Arg Gly Glu Ile 260 265 270 Gly Pro Tyr Phe Ile Glu Asp Val Ala Ile Ile Glu Glu Asp Asn Arg 275 280 285 Lys Leu Gln Lys Leu Asn Glu Asn Thr Ala Asp Asn Val Arg Arg Gly 290 295 300 Leu Thr Pro Arg Trp Ser Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Ala Lys Tyr Ile Gly Trp Ile Leu Glu Ser Ala Pro Gly Ser Ile Leu 325 330 335 Glu Ser His Glu Leu Ser Cys Met Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Lys Asp Ser Val Leu Gln Ser Met Thr Ala Val Ser Gly Gly Gly 355 360 365 Ser Ala Ala Gly Gly Ser Pro Glu Ser Ser Val Glu Cys Asp His Leu 370 375 380 Leu Gln Leu Glu Ser Gly Pro Glu Val Val Arg Gly Arg Thr Glu Trp 385 390 395 400 Arg Pro Lys Ser Ala Asn Asn Ser Arg Ser Ile Leu Glu Met Pro Ala 405 410 415 Glu Ser Leu <210> 132 <211> 410 <212> PRT <213> Cuphea heterophylla <400> 132 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Pro 1 5 10 15 Gly Thr Ser Thr Lys Pro Gly Asn Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Pro Glu Ser Asn His Asn Gly Gly Phe Arg Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Glu Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Ile Lys Gln Leu Pro Asp Trp Gly Met Leu 85 90 95 Leu Ser Lys Ile Thr Thr Val Phe Gly Ala Ala Glu Arg Gln Trp Lys 100 105 110 Arg Pro Gly Met Leu Val Glu Pro Phe Gly Val Asp Arg Ile Phe Gln 115 120 125 Asp Gly Val Phe Phe Arg Gln Ser Phe Ser Ile Arg Ser Tyr Glu Ile 130 135 140 Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Leu Met Asn Ile Phe Gln 145 150 155 160 Glu Thr Ser Leu Asn His Cys Lys Ser Ile Gly Leu Leu Asn Asp Gly 165 170 175 Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu Ile Trp Val Val 180 185 190 Thr Lys Ile Gln Val Glu Val Asn Arg Tyr Pro Thr Trp Gly Asp Thr 195 200 205 Ile Glu Val Asn Thr Trp Val Ser Glu Ser Gly Lys Asn Gly Met Gly 210 215 220 Arg Asp Trp Leu Ile Ser Asp Cys Arg Thr Gly Glu Ile Leu Ile Arg 225 230 235 240 Ala Thr Ser Val Trp Ala Met Met Asn Arg Lys Thr Arg Arg Leu Ser 245 250 255 Lys Phe Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro His Phe Val Asp 260 265 270 Ser Ala Pro Val Ile Glu Asp Asp Lys Lys Leu His Lys Leu Asp Val 275 280 285 Lys Thr Gly Asp Ser Ile Arg Lys Gly Leu Thr Pro Arg Trp Asn Asp 290 295 300 Leu Asp Val Asn Gln His Val Asn Asn Val Lys Tyr Ile Gly Trp Ile 305 310 315 320 Leu Lys Ser Val Pro Ala Glu Val Phe Glu Thr Gln Glu Leu Cys Gly 325 330 335 Val Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg Asp Ser Val Leu Glu 340 345 350 Ser Val Thr Ala Met Asp Thr Ala Lys Glu Gly Asp Arg Ser Leu Tyr 355 360 365 Gln His Leu Leu Arg Leu Glu Asp Gly Ala Asp Ile Thr Ile Gly Arg 370 375 380 Thr Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn Gly Ala Ile Ser Thr 385 390 395 400 Gly Lys Thr Ser Asn Glu Asn Ser Val Ser 405 410 <210> 133 <211> 410 <212> PRT <213> Cuphea heterophylla <400> 133 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Asn Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Pro Glu Ser Asn His Asn Gly Gly Phe Arg Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Glu Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Ile Lys Gln Leu Pro Asp Trp Gly Met Leu 85 90 95 Leu Ser Lys Ile Thr Thr Val Phe Gly Ala Ala Glu Arg Gln Trp Lys 100 105 110 Arg Pro Gly Met Leu Val Glu Pro Phe Gly Val Asp Arg Ile Phe Gln 115 120 125 Asp Gly Val Phe Phe Arg His Ser Phe Ser Ile Arg Ser Tyr Glu Ile 130 135 140 Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Leu Met Asn Ile Phe Gln 145 150 155 160 Glu Thr Ser Leu Asn His Cys Lys Ser Ile Gly Leu Leu Asn Asp Gly 165 170 175 Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu Ile Trp Val Val 180 185 190 Thr Lys Ile Gln Val Glu Val Asn Arg Tyr Pro Thr Trp Gly Asp Thr 195 200 205 Ile Glu Val Asn Thr Trp Val Ser Glu Ser Gly Lys Asn Gly Met Gly 210 215 220 Arg Asp Trp Leu Ile Gly Asp Cys Arg Thr Gly Glu Ile Leu Ile Arg 225 230 235 240 Ala Thr Ser Val Trp Ala Met Met Asn Arg Lys Thr Arg Arg Leu Ser 245 250 255 Lys Phe Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro His Phe Val Asp 260 265 270 Ser Ala Pro Val Ile Glu Asp Asp Lys Lys Leu His Lys Leu Asp Val 275 280 285 Lys Thr Gly Asp Ser Ile Arg Lys Gly Leu Thr Pro Arg Trp Asn Asp 290 295 300 Leu Asp Val Asn Gln His Val Asn Asn Val Lys Tyr Ile Gly Trp Ile 305 310 315 320 Leu Lys Ser Val Pro Ala Glu Val Phe Glu Thr Gln Glu Leu Cys Gly 325 330 335 Val Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg Asp Ser Val Leu Glu 340 345 350 Ser Val Thr Ala Met Asp Thr Ala Lys Glu Gly Asp Arg Ser Leu Tyr 355 360 365 Gln His Leu Leu Arg Leu Glu Asp Gly Ala Asp Ile Thr Ile Gly Arg 370 375 380 Thr Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn Gly Ala Leu Ser Thr 385 390 395 400 Gly Lys Thr Ser Asn Gly Asn Ser Val Ser 405 410 <210> 134 <211> 410 <212> PRT <213> Cuphea heterophylla <400> 134 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Asn Phe Gly Asn Trp Pro Ser Asn Leu 20 25 30 Ser Val Pro Phe Lys Pro Glu Ser Asn His Asn Gly Gly Phe Arg Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Glu Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Ile Lys Gln Leu Pro Asp Trp Gly Met Leu 85 90 95 Leu Ser Lys Ile Thr Thr Val Phe Gly Ala Ala Glu Arg Gln Trp Lys 100 105 110 Arg Pro Gly Met Leu Val Glu Pro Phe Gly Val Asp Arg Ile Phe Gln 115 120 125 Asp Gly Val Phe Phe Arg Gln Ser Phe Ser Ile Arg Ser Tyr Glu Ile 130 135 140 Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Leu Met Asn Ile Phe Gln 145 150 155 160 Glu Thr Ser Leu Asn His Cys Lys Ser Ile Gly Leu Leu Asn Asp Gly 165 170 175 Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu Ile Trp Val Val 180 185 190 Thr Lys Ile Gln Val Glu Val Asn Arg Tyr Pro Thr Trp Gly Asp Thr 195 200 205 Ile Glu Val Asn Thr Trp Val Ser Glu Ser Gly Lys Asn Gly Met Gly 210 215 220 Arg Asp Trp Leu Ile Ser Asp Cys Arg Thr Gly Glu Ile Leu Ile Arg 225 230 235 240 Ala Thr Ser Val Trp Ala Met Met Asn Arg Lys Thr Arg Arg Leu Ser 245 250 255 Lys Phe Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro His Phe Val Asp 260 265 270 Ser Ala Pro Val Ile Glu Asp Asp Lys Lys Leu His Lys Leu Asp Val 275 280 285 Lys Thr Gly Asp Ser Ile Arg Lys Gly Leu Thr Pro Arg Trp Asn Asp 290 295 300 Phe Asp Val Asn Gln His Val Asn Asn Val Lys Tyr Ile Gly Trp Ile 305 310 315 320 Leu Lys Ser Val Pro Ala Glu Val Phe Glu Thr Gln Glu Leu Cys Gly 325 330 335 Val Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg Asp Ser Val Leu Glu 340 345 350 Ser Val Thr Ala Met Asp Thr Ala Lys Glu Gly Asp Arg Ser Leu Tyr 355 360 365 Gln His Leu Leu Arg Leu Glu Asp Gly Ala Asp Ile Thr Ile Gly Arg 370 375 380 Thr Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn Gly Ala Ile Ser Thr 385 390 395 400 Gly Lys Thr Ser Asn Glu Asn Ser Val Ser 405 410 <210> 135 <211> 410 <212> PRT <213> Cuphea heterophylla <400> 135 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Asn Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Pro Glu Ser Asn His Asn Gly Gly Phe Arg Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Glu Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Ile Lys Gln Leu Pro Asp Trp Gly Met Leu 85 90 95 Leu Ser Lys Ile Thr Thr Val Phe Gly Ala Ala Glu Arg Gln Trp Lys 100 105 110 Arg Pro Gly Met Leu Val Glu Pro Phe Gly Val Asp Arg Ile Phe Gln 115 120 125 Asp Gly Val Phe Phe Arg Gln Ser Phe Ser Ile Arg Ser Tyr Glu Ile 130 135 140 Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Leu Met Asn Ile Phe Gln 145 150 155 160 Glu Thr Ser Leu Asn His Cys Lys Ser Ile Gly Leu Leu Asn Asp Gly 165 170 175 Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu Ile Trp Val Val 180 185 190 Thr Lys Ile Gln Val Glu Val Asn Arg Tyr Pro Thr Trp Gly Asp Thr 195 200 205 Ile Glu Val Asn Thr Trp Val Ser Glu Ser Gly Lys Asn Gly Met Gly 210 215 220 Arg Asp Trp Leu Ile Ser Asp Cys Arg Thr Gly Glu Ile Leu Ile Arg 225 230 235 240 Ala Thr Ser Val Trp Ala Met Met Asn Arg Lys Thr Arg Arg Leu Ser 245 250 255 Lys Phe Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro His Phe Val Asp 260 265 270 Ser Ala Pro Val Ile Glu Asp Asp Lys Lys Leu His Lys Leu Asp Val 275 280 285 Lys Thr Gly Asp Ser Ile Arg Lys Gly Leu Thr Pro Arg Trp Asn Asp 290 295 300 Phe Asp Val Asn Gln His Val Asn Asn Val Lys Tyr Ile Gly Trp Ile 305 310 315 320 Leu Lys Ser Val Pro Ala Glu Val Phe Glu Thr Gln Glu Leu Cys Gly 325 330 335 Val Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg Asp Ser Val Leu Glu 340 345 350 Ser Val Thr Ala Met Asp Thr Ala Lys Glu Gly Asp Arg Ser Leu Tyr 355 360 365 Gln His Leu Leu Arg Leu Glu Asp Gly Ala Asp Ile Thr Ile Gly Arg 370 375 380 Thr Glu Trp Arg Pro Lys Asn Ala Gly Val Asn Gly Ala Ile Ser Thr 385 390 395 400 Gly Lys Thr Ser Asn Glu Asn Ser Val Ser 405 410 <210> 136 <211> 410 <212> PRT <213> Cuphea heterophylla <400> 136 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Asn Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Pro Glu Ser Asn His Asn Gly Gly Phe Arg Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Glu Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Ile Lys Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Lys Ile Thr Thr Val Phe Gly Ala Ala Glu Arg Gln Trp Lys 100 105 110 Arg Pro Gly Met Leu Val Glu Pro Phe Gly Val Asp Arg Ile Phe Gln 115 120 125 Asp Gly Val Phe Phe Arg Gln Ser Phe Ser Ile Arg Ser Tyr Glu Ile 130 135 140 Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Leu Met Asn Ile Phe Gln 145 150 155 160 Glu Thr Ser Leu Asn His Cys Lys Ser Ile Gly Leu Leu Asn Asp Gly 165 170 175 Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu Ile Trp Val Val 180 185 190 Thr Lys Ile Gln Val Glu Val Asn Arg Tyr Pro Thr Trp Gly Asp Thr 195 200 205 Ile Glu Val Asn Thr Trp Val Ser Glu Ser Gly Lys Asn Gly Met Gly 210 215 220 Arg Asp Trp Leu Ile Ser Asp Cys Arg Thr Gly Glu Ile Leu Ile Arg 225 230 235 240 Ala Thr Ser Val Trp Ala Met Met Asn Arg Lys Thr Arg Arg Leu Ser 245 250 255 Lys Phe Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro His Phe Val Asp 260 265 270 Ser Ala Pro Val Ile Glu Asp Asp Lys Lys Leu His Lys Leu Asp Val 275 280 285 Lys Thr Gly Asp Ser Ile Arg Lys Gly Leu Thr Pro Arg Trp Asn Asp 290 295 300 Phe Asp Val Asn Gln His Val Asn Asn Val Lys Tyr Ile Gly Trp Ile 305 310 315 320 Leu Lys Ser Val Pro Ala Glu Val Phe Glu Thr Gln Glu Leu Cys Gly 325 330 335 Val Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg Asp Ser Val Leu Glu 340 345 350 Ser Val Thr Ala Met Asp Thr Ala Lys Glu Gly Asp Arg Ser Leu Tyr 355 360 365 Gln His Leu Leu Arg Leu Glu Asp Gly Ala Asp Ile Thr Ile Gly Arg 370 375 380 Thr Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn Gly Ala Ile Ser Thr 385 390 395 400 Gly Lys Thr Ser Asn Glu Asn Ser Val Ser 405 410 <210> 137 <211> 410 <212> PRT <213> Cuphea heterophylla <400> 137 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Thr Ser 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Asn Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Pro Glu Ser Ser His Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Glu Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Ile Lys Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Lys Ile Thr Thr Val Phe Trp Ala Ala Glu Arg Gln Trp Lys 100 105 110 Arg Pro Gly Met Leu Val Glu Pro Phe Gly Val Asp Arg Ile Phe Gln 115 120 125 Asp Gly Val Phe Phe Arg Gln Ser Phe Ser Ile Arg Ser Tyr Glu Ile 130 135 140 Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Leu Met Asn Ile Phe Gln 145 150 155 160 Glu Thr Ser Leu Asn His Cys Lys Ser Ile Gly Leu Leu Asn Asp Gly 165 170 175 Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp Leu Ile Trp Val Val 180 185 190 Thr Lys Ile Gln Val Glu Val Asn Arg Tyr Pro Thr Trp Gly Asp Thr 195 200 205 Ile Glu Val Asn Thr Trp Val Ser Glu Ser Gly Lys Asn Gly Met Gly 210 215 220 Arg Asp Trp Leu Ile Ser Asp Cys Arg Thr Gly Glu Ile Leu Ile Arg 225 230 235 240 Ala Thr Ser Val Trp Ala Met Met Asn Arg Lys Thr Arg Arg Leu Ser 245 250 255 Lys Phe Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro His Phe Val Asp 260 265 270 Ser Ala Pro Val Ile Glu Asp Asp Lys Lys Leu His Lys Leu Asp Val 275 280 285 Lys Thr Gly Asp Phe Ile Arg Lys Gly Leu Thr Pro Arg Trp Asn Asp 290 295 300 Phe Asp Val Asn Gln His Val Asn Asn Val Lys Tyr Ile Gly Trp Ile 305 310 315 320 Leu Lys Ser Val Pro Ala Glu Val Phe Glu Thr Gln Glu Leu Cys Gly 325 330 335 Val Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg Asp Ser Val Leu Glu 340 345 350 Ser Val Thr Ala Met Asp Thr Ala Lys Glu Gly Asp Arg Ser Leu Tyr 355 360 365 Gln His Leu Leu Arg Leu Glu Asp Gly Ala Asp Ile Thr Ile Gly Arg 370 375 380 Thr Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn Gly Ala Ile Ser Thr 385 390 395 400 Gly Lys Thr Ser Asn Glu Asn Ser Val Ser 405 410 <210> 138 <211> 418 <212> PRT <213> Cuphea heterophylla <400> 138 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Ser Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Thr Trp Leu Ser Ser 20 25 30 Ser Ser Pro Ser Tyr Lys Pro Lys Ser Asn Pro Ser Gly Gly Phe Gln 35 40 45 Val Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Gly Thr Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Arg Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Leu Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Lys Pro Asp Met His Val Asp Trp Phe 115 120 125 Gly Leu Glu Ile Ile Val Gln Asp Gly Leu Val Phe Arg Glu Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn His Leu Gln Asp Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Val Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asn Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ile Trp Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Cys Lys 290 295 300 Gly Leu Thr Pro Glu Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Lys Glu Val 325 330 335 Leu Asp Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Thr Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser 405 410 415 Val Ser <210> 139 <211> 418 <212> PRT <213> Cuphea heterophylla <400> 139 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Pro Gly Thr Thr Ser Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser 20 25 30 Leu Ser Pro Ser Phe Lys Pro Lys Ser Asn Pro Asn Gly Gly Phe Gln 35 40 45 Val Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Lys Glu Asp Thr Pro Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Arg Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Leu Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Lys Pro Asp Met His Val Asp Trp Phe 115 120 125 Gly Leu Glu Ile Ile Val Gln Asp Trp Leu Val Phe Arg Glu Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn His Leu Gln Asp Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Val Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asn Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ile Trp Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Leu Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Cys Lys 290 295 300 Gly Leu Thr Pro Glu Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Lys Glu Val 325 330 335 Leu Asp Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Thr Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser 405 410 415 Val Ser <210> 140 <211> 418 <212> PRT <213> Cuphea heterophylla <400> 140 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Ser Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Thr Trp Leu Ser Ser 20 25 30 Ser Ser Pro Ser Tyr Lys Pro Lys Ser Asn Pro Ser Gly Gly Phe Gln 35 40 45 Val Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Lys Glu Asp Thr Pro Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Asn Arg Leu 85 90 95 Arg Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Leu Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Lys Pro Asp Met His Val Asp Trp Phe 115 120 125 Gly Leu Glu Ile Ile Val Gln Asp Gly Leu Val Phe Arg Glu Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn His Leu Gln Asp Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Val Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asn Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ile Trp Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Cys Lys 290 295 300 Gly Leu Thr Pro Glu Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Lys Glu Val 325 330 335 Leu Asp Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Thr Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser 405 410 415 Val Ser <210> 141 <211> 418 <212> PRT <213> Cuphea heterophylla <400> 141 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Pro Gly Thr Thr Ser Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser 20 25 30 Leu Ser Pro Ser Phe Lys Pro Lys Ser Asn Pro Asn Gly Gly Phe Gln 35 40 45 Val Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Leu Thr Ala Ile Ser Thr Val Phe Val Ala Ala Glu Lys Gln Leu Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Leu Phe 115 120 125 Gly Leu Glu Ser Ile Val Gln Asp Gly Leu Val Phe Arg Glu Ser Tyr 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn His Leu Gln Asp Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Val Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asn Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ile Trp Ala Met Met Asn 245 250 255 Gln Asn Thr Arg Arg Phe Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys 290 295 300 Gly Leu Thr Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val 325 330 335 Leu Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Glu Ser Val Leu Glu Ser Val Thr Ala Met Asn Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Ala Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser 405 410 415 Val Ser <210> 142 <211> 418 <212> PRT <213> Cuphea heterophylla <400> 142 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Ser Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Thr Trp Leu Ser Ser 20 25 30 Ser Ser Pro Ser Tyr Lys Pro Lys Ser Asn Pro Ser Gly Gly Phe Gln 35 40 45 Val Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser 65 70 75 80 Pro Pro Pro Gln Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Leu Thr Ala Ile Ser Thr Val Phe Val Ala Ala Glu Lys Gln Leu Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Trp Phe 115 120 125 Gly Leu Glu Ser Ile Val Gln Asp Gly Leu Val Phe Arg Glu Ser Tyr 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Ser Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Val Met Asn Leu Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Met Gly Ile Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Leu Val Asn Arg 195 200 205 Tyr Pro Asn Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asn Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ile Trp Ala Met Met Asn 245 250 255 Gln Asn Thr Arg Arg Phe Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys 290 295 300 Gly Leu Thr Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val 325 330 335 Leu Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asn Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Ala Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser 405 410 415 Val Ser <210> 143 <211> 418 <212> PRT <213> Cuphea heterophylla <400> 143 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Ser Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Thr Trp Leu Ser Ser 20 25 30 Ser Ser Pro Ser Tyr Lys Pro Lys Ser Asn Pro Ser Gly Gly Phe Gln 35 40 45 Val Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Gly Thr Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Leu Thr Ala Ile Ser Thr Val Phe Val Ala Ala Glu Lys Gln Leu Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Trp Phe 115 120 125 Gly Leu Glu Ser Ile Val Gln Asp Gly Leu Val Phe Arg Glu Ser Tyr 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Ser Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Val Met Asn Leu Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Met Gly Ile Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Leu Val Asn Arg 195 200 205 Tyr Pro Asn Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asn Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ile Trp Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Cys Lys 290 295 300 Gly Leu Thr Pro Glu Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Lys Glu Val 325 330 335 Leu Asp Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Thr Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser 405 410 415 Val Ser <210> 144 <211> 418 <212> PRT <213> Cuphea heterophylla <400> 144 Met Val Val Ala Ala Thr Ala Ser Ser Ala Phe Phe Pro Val Pro Val 1 5 10 15 Pro Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Thr Trp Leu Ser Ser 20 25 30 Ser Ser Pro Ser Tyr Lys Pro Lys Ser Asn Pro Ser Gly Gly Phe Gln 35 40 45 Val Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Leu Thr Ala Ile Ser Thr Val Phe Val Ala Ala Glu Lys Gln Leu Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Trp Phe 115 120 125 Gly Leu Glu Ser Ile Val Gln Asp Gly Leu Val Phe Arg Glu Ile Tyr 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Ser Ala Asp Arg Thr Thr Ser Ile Glu 145 150 155 160 Thr Val Met Asn Leu Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Met Gly Ile Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Leu Val Asn Arg 195 200 205 Tyr Pro Asn Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asn Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ile Trp Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Cys Lys 290 295 300 Gly Leu Thr Pro Glu Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Lys Glu Val 325 330 335 Leu Asp Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Thr Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Ala Asn Ser 405 410 415 Val Ser <210> 145 <211> 418 <212> PRT <213> Cuphea heterophylla <400> 145 Met Val Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala 1 5 10 15 Ser Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Thr Trp Leu Ser Ser 20 25 30 Ser Ser Pro Ser Tyr Lys Pro Lys Ser Asn Pro Ser Gly Gly Phe Gln 35 40 45 Val Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val 50 55 60 Ser Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Gly Thr Ser Ser Ser 65 70 75 80 Pro Pro Pro Arg Thr Phe Leu Asn Gln Leu Pro Asp Trp Ser Arg Leu 85 90 95 Leu Thr Ala Ile Ser Thr Val Phe Val Ala Ala Glu Lys Gln Leu Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Trp Phe 115 120 125 Gly Leu Glu Ser Ile Val Gln Asp Gly Leu Val Phe Arg Glu Ser Tyr 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Ser Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Val Met Asn Leu Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Met Gly Ile Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Leu Val Asn Arg 195 200 205 Tyr Pro Asn Trp Gly Asp Thr Val Glu Ile Asn Ser Trp Phe Ser Gln 210 215 220 Ser Gly Lys Ile Gly Met Gly Arg Asn Trp Leu Ile Ser Asp Cys Asn 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ile Trp Ala Met Met Asn 245 250 255 Gln Asn Thr Arg Arg Phe Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 260 265 270 Ile Ala Pro His Phe Val Asp Ala Pro Pro Val Ile Glu Asp Asn Asp 275 280 285 Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys 290 295 300 Gly Leu Thr Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Ser 305 310 315 320 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Ile Pro Thr Glu Val 325 330 335 Leu Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu 340 345 350 Cys Gly Arg Glu Ser Val Leu Glu Ser Val Thr Ala Met Asn Pro Ser 355 360 365 Lys Val Gly Asp Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Ala Asp Ile Met Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser 405 410 415 Val Ser <210> 146 <211> 414 <212> PRT <213> Cuphea heterophylla <400> 146 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Thr Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Arg Pro Leu Lys Pro Lys Phe Val Ala Asn Ala Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Ser Leu 50 55 60 Lys Ser Cys Ser Leu Lys Thr His Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Glu Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Lys Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Trp Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys 355 360 365 Gly Phe Gly Pro Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile 385 390 395 400 Asn Gly Thr Ile Ala Ser Gly Glu Thr Ser Pro Gly Asn Ser 405 410 <210> 147 <211> 414 <212> PRT <213> Cuphea heterophylla <400> 147 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Thr Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Arg Pro Leu Lys Pro Lys Phe Val Ala Asn Ala Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Ser Leu 50 55 60 Lys Ser Gly Ser Leu Lys Thr Gln Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly Phe 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Ile Glu Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Lys Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Trp Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys 355 360 365 Gly Phe Gly Pro Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile 385 390 395 400 Asn Gly Thr Ile Ala Ser Gly Glu Thr Ser Pro Gly Asn Ser 405 410 <210> 148 <211> 414 <212> PRT <213> Cuphea heterophylla <400> 148 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Thr Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Arg Pro Leu Lys Pro Lys Phe Val Ala Asn Ala Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Ser Leu 50 55 60 Lys Ser Cys Ser Leu Lys Thr His Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Glu Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Lys Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Arg Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Glu Lys 355 360 365 Gly Phe Gly Pro Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile 385 390 395 400 Asn Gly Ala Ile Ala Phe Gly Glu Thr Ser Pro Gly Asp Ser 405 410 <210> 149 <211> 414 <212> PRT <213> Cuphea heterophylla <400> 149 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Thr Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Arg Pro Leu Lys Pro Lys Phe Val Ala Asn Ala Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Ser Leu 50 55 60 Lys Ser Cys Ser Leu Lys Thr His Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Lys Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Glu Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Lys Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Trp Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys 355 360 365 Gly Phe Gly Pro Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile 385 390 395 400 Asn Gly Thr Ile Ala Ser Gly Glu Thr Ser Pro Gly Asn Ser 405 410 <210> 150 <211> 414 <212> PRT <213> Cuphea heterophylla <400> 150 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Thr Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Arg Pro Leu Lys Pro Lys Phe Val Ala Asn Ala Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Ser Leu 50 55 60 Lys Ser Gly Ser Leu Lys Thr His Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Glu Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Lys Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Trp Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys 355 360 365 Gly Phe Gly Pro Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile 385 390 395 400 Asn Gly Thr Ile Ala Ser Gly Glu Thr Ser Pro Gly Asn Ser 405 410 <210> 151 <211> 414 <212> PRT <213> Cuphea heterophylla <400> 151 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Thr Ser Ser Arg Leu Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Arg Pro Leu Lys Pro Lys Phe Val Ala Asn Ala Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Ser Leu 50 55 60 Lys Ser Gly Ser Leu Lys Thr Gln Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Pro Val Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Glu Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Lys Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Trp Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Glu Lys 355 360 365 Gly Phe Gly Pro Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile 385 390 395 400 Asn Gly Thr Ile Ala Ser Gly Glu Thr Ser Pro Gly Asn Ser 405 410 <210> 152 <211> 414 <212> PRT <213> Cuphea heterophylla <400> 152 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Thr Ser Ser Arg Ala Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Arg Pro Leu Lys Pro Lys Phe Val Ala Asn Ala Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Ser Leu 50 55 60 Lys Ser Gly Ser Leu Lys Thr Gln Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Glu Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Lys Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Trp Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys 355 360 365 Gly Phe Gly Pro Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile 385 390 395 400 Asn Gly Thr Ile Ala Ser Gly Glu Thr Ser Pro Gly Asn Ser 405 410 <210> 153 <211> 361 <212> PRT <213> Cuphea hyssopifolia <400> 153 Met Val Ala Thr Asn Ala Ala Ala Phe Ser Ala Tyr Thr Phe Phe Leu 1 5 10 15 Thr Ser Pro Thr His Gly Tyr Ser Ser Lys Arg Leu Ala Asp Thr Gln 20 25 30 Asn Gly Tyr Pro Gly Thr Ser Leu Lys Ser Lys Ser Thr Pro Pro Pro 35 40 45 Ala Ala Ala Ala Ala Arg Asn Gly Ala Leu Pro Leu Leu Ala Ser Ile 50 55 60 Cys Lys Cys Pro Lys Lys Ala Asp Gly Ser Met Gln Leu Asp Ser Ser 65 70 75 80 Leu Val Phe Gly Phe Gln Phe Tyr Ile Arg Ser Tyr Glu Val Gly Ala 85 90 95 Asp Gln Thr Val Ser Ile Gln Thr Val Leu Asn Tyr Leu Gln Glu Ala 100 105 110 Ala Ile Asn His Val Gln Ser Ala Gly Tyr Phe Gly Asp Ser Phe Gly 115 120 125 Ala Thr Pro Glu Met Thr Lys Arg Asn Leu Ile Trp Val Ile Thr Lys 130 135 140 Met Gln Val Leu Val Asp Arg Tyr Pro Ala Trp Gly Asp Val Val Gln 145 150 155 160 Val Asp Thr Trp Thr Cys Ser Ser Gly Lys Asn Ser Met Gln Arg Asp 165 170 175 Trp Phe Val Arg Asp Leu Lys Thr Gly Asp Ile Ile Thr Arg Ala Ser 180 185 190 Ser Val Trp Val Leu Met Asn Arg Leu Thr Arg Lys Leu Ser Lys Ile 195 200 205 Pro Glu Ala Val Leu Glu Glu Ala Lys Leu Phe Val Met Asn Thr Ala 210 215 220 Pro Thr Val Asp Asp Asn Arg Lys Leu Pro Lys Leu Asp Gly Ser Ser 225 230 235 240 Ala Asp Tyr Val Leu Ser Gly Leu Thr Pro Arg Trp Ser Asp Leu Asp 245 250 255 Met Asn Gln His Val Asn Asn Val Lys Tyr Ile Ala Trp Ile Leu Glu 260 265 270 Ser Val Pro Gln Ser Ile Pro Glu Thr His Lys Leu Ser Ala Ile Thr 275 280 285 Val Glu Tyr Arg Arg Glu Cys Gly Lys Asn Ser Val Leu Gln Ser Leu 290 295 300 Thr Asn Val Ser Gly Asp Gly Ile Thr Cys Gly Asn Ser Ile Ile Glu 305 310 315 320 Cys His His Leu Leu Gln Leu Glu Thr Gly Pro Glu Ile Leu Leu Ala 325 330 335 Arg Thr Glu Trp Ile Ser Lys Glu Pro Gly Phe Arg Gly Ala Pro Ile 340 345 350 Gln Ala Glu Lys Val Tyr Asn Asn Lys 355 360 <210> 154 <211> 415 <212> PRT <213> Cuphea hyssopifolia <400> 154 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Ala Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Ser Pro Leu Lys Pro Lys Leu Met Ala Asn Gly Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly Leu 50 55 60 Lys Ser Gly Ser Leu Lys Thr Gln Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Asp Gly Phe Gly Arg Thr Leu Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Arg Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys 355 360 365 Gly Ser Gly Ser Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile 385 390 395 400 Asn Gly Pro Ile Ala Ser Gly Glu Thr Ser Pro Gly Asp Ser Ser 405 410 415 <210> 155 <211> 427 <212> PRT <213> Cuphea hyssopifolia <400> 155 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Ala Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Ser Pro Leu Lys Pro Lys Leu Met Ala Asn Gly Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly Leu 50 55 60 Lys Ser Gly Ser Leu Lys Thr Gln Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Asp Gly Phe Gly Arg Thr Leu Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Lys Ser Gln Ile Met Leu Pro Leu 245 250 255 His Tyr Cys Ser Val Trp Val Met Met Asn Gln Lys Thr Arg Arg Leu 260 265 270 Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu Pro His Phe Val 275 280 285 Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Arg Lys Leu Pro Lys Leu 290 295 300 Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu Thr Pro Lys Trp 305 310 315 320 Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val Lys Tyr Ile Gly 325 330 335 Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu Thr Gln Glu Leu 340 345 350 Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg Glu Ser Val 355 360 365 Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys Gly Ser Gly Ser 370 375 380 Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly Glu Ile Val Lys 385 390 395 400 Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile Asn Gly Pro Ile 405 410 415 Ala Ser Gly Glu Thr Ser Pro Gly Asp Ser Ser 420 425 <210> 156 <211> 415 <212> PRT <213> Cuphea hyssopifolia <400> 156 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Ala Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Ser Pro Leu Lys Pro Lys Leu Met Ala Asn Gly Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly Leu 50 55 60 Lys Ser Gly Ser Leu Lys Thr Gln Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Asp Gly Phe Gly Arg Thr Leu Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Arg Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys 355 360 365 Gly Ser Gly Ser Gln Phe Gln His Leu Met Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile 385 390 395 400 Asn Gly Pro Ile Ala Ser Gly Glu Thr Ser Pro Gly Asp Ser Ser 405 410 415 <210> 157 <211> 415 <212> PRT <213> Cuphea hyssopifolia <400> 157 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Ala Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Ser Ser Ser Leu 20 25 30 Ser Pro Leu Lys Pro Lys Leu Met Ala Asn Gly Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly Leu 50 55 60 Lys Ser Gly Ser Leu Lys Thr Gln Glu Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Val Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Arg Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys 355 360 365 Gly Ser Gly Ser Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly Ile 385 390 395 400 Asn Gly Pro Ile Ala Ser Gly Glu Thr Ser Pro Gly Asp Ser Ser 405 410 415 <210> 158 <211> 417 <212> PRT <213> Cuphea hyssopifolia <400> 158 Met Val Ala Ala Glu Ala Ser Ser Ala Leu Phe Ser Val Arg Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Thr Ser Leu 20 25 30 Ser Val Pro Phe Lys Ser Lys Ser Asn His Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Arg Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asp Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Ser Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Met Asp Pro Phe 115 120 125 Gly Val Asp Arg Val Val Gln Asp Gly Ala Val Phe Arg Gln Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Ile Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Val Thr Lys Met His Val Glu Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu 210 215 220 Ser Gly Lys Thr Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys His 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Met Cys Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu 260 265 270 Leu Ala Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Tyr Gln 275 280 285 Lys Leu His Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Cys Asn Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Val Pro Thr Glu Val Phe 325 330 335 Glu Thr Gln Glu Leu Cys Gly Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys 355 360 365 Glu Gly Asp Arg Ser Leu Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Ala Asp Ile Ala Lys Gly Arg Thr Lys Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser Ile 405 410 415 Ser <210> 159 <211> 417 <212> PRT <213> Cuphea hyssopifolia <400> 159 Met Val Ala Ala Glu Ala Ser Ser Ala Leu Phe Ser Val Arg Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Thr Ser Leu 20 25 30 Ser Val Pro Phe Lys Ser Lys Ser Asn His Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Arg Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asp Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Ser Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Met Asp Pro Phe 115 120 125 Gly Val Asp Arg Val Val Gln Asp Gly Ala Val Phe Arg Gln Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Ile Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Val Thr Lys Met His Ile Glu Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu 210 215 220 Ser Gly Lys Thr Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Phe His 225 230 235 240 Thr Gly Asp Ile Leu Ile Arg Ala Thr Ser Val Cys Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu 260 265 270 Leu Ala Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Tyr Gln 275 280 285 Lys Leu His Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Cys Asn Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Val Pro Thr Glu Val Phe 325 330 335 Glu Thr Gln Glu Leu Cys Gly Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys 355 360 365 Glu Gly Asp Arg Ser Leu Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Ala Asp Ile Ala Lys Gly Arg Thr Lys Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser Ile 405 410 415 Ser <210> 160 <211> 409 <212> PRT <213> Cuphea hyssopifolia <400> 160 Met Val Ala Ala Glu Ala Ser Ser Ala Leu Phe Ser Val Arg Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Thr Ser Leu 20 25 30 Ser Val Pro Phe Lys Ser Lys Ser Asn His Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Arg Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asp Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Ser Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Met Asp Pro Phe 115 120 125 Gly Val Asp Arg Val Val Gln Asp Gly Ala Val Phe Arg Gln Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Ile Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Val Thr Lys Met His Val Glu Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu 210 215 220 Ser Gly Lys Thr Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys His 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Met Cys Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu 260 265 270 Leu Ala Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Tyr Gln 275 280 285 Lys Leu His Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Cys Asn Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Val Pro Thr Glu Val Phe 325 330 335 Glu Thr Gln Glu Leu Cys Gly Leu Thr Leu Glu Tyr Arg Gln Glu Cys 340 345 350 Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys 355 360 365 Glu Gly Asp Arg Ser Leu Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Ile Ala Lys Gly Arg Thr Lys Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Lys Thr Ser Asn Gly Asn Ser Ile Ser 405 <210> 161 <211> 417 <212> PRT <213> Cuphea hyssopifolia <400> 161 Met Val Ala Ala Glu Ala Ser Ser Ala Leu Phe Ser Val Arg Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Ser Lys Ser Asn His Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Arg Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asp Thr Gln Glu Asp Ala Ser Ser Ser Ser 65 70 75 80 Ser Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Ser Asp Met Leu Met Asp Pro Phe 115 120 125 Gly Val Asp Arg Val Val Gln Asp Gly Ala Val Phe Arg Gln Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Ile Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Val Thr Lys Met His Val Glu Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu 210 215 220 Ser Gly Lys Thr Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys His 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Met Cys Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu 260 265 270 Leu Ala Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Tyr Gln 275 280 285 Lys Leu His Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Cys Asn Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Val Pro Thr Glu Val Phe 325 330 335 Glu Thr Gln Glu Leu Cys Gly Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys 355 360 365 Glu Gly Asp Arg Ser Leu Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Ala Asp Ile Ala Lys Gly Arg Thr Lys Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser Ile 405 410 415 Ser <210> 162 <211> 417 <212> PRT <213> Cuphea hyssopifolia <400> 162 Met Val Ala Ala Glu Ala Ser Ser Ala Leu Phe Ser Val Arg Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Ser Lys Ser Asn His Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Arg Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asp Thr Gln Glu Asp Ala Ser Ser Ser Ser 65 70 75 80 Ser Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Ser Asp Met Leu Met Asp Pro Phe 115 120 125 Gly Val Asp Arg Val Val Gln Asp Gly Val Val Phe Arg Gln Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Ile Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Val Thr Lys Met His Val Glu Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu 210 215 220 Ser Gly Lys Thr Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys His 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Met Cys Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu 260 265 270 Leu Ala Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Tyr Gln 275 280 285 Lys Leu His Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Cys Asn Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Val Pro Thr Glu Val Phe 325 330 335 Glu Thr Gln Glu Leu Cys Gly Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys 355 360 365 Glu Gly Asp Arg Ser Leu Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Ala Asp Ile Ala Lys Gly Arg Thr Lys Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser Ile 405 410 415 Ser <210> 163 <211> 417 <212> PRT <213> Cuphea hyssopifolia <400> 163 Met Val Ala Ala Glu Ala Ser Ser Ala Leu Phe Ser Val Arg Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Ser Lys Ser Asn His Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Arg Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asp Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Ser Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Met Asp Pro Phe 115 120 125 Gly Val Asp Arg Val Val Gln Asp Gly Ala Val Phe Arg Gln Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Ile Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Val Thr Lys Met His Val Glu Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu 210 215 220 Ser Gly Lys Thr Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys His 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Met Cys Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu 260 265 270 Leu Ala Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Tyr Gln 275 280 285 Lys Leu His Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Cys Asn Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Val Pro Thr Glu Val Phe 325 330 335 Glu Thr Gln Glu Leu Cys Gly Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys 355 360 365 Glu Gly Asp Arg Ser Leu Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Ala Asp Ile Ala Lys Gly Arg Thr Lys Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser Ile 405 410 415 Ser <210> 164 <211> 409 <212> PRT <213> Cuphea hyssopifolia <400> 164 Met Val Ala Ala Glu Ala Ser Ser Ala Leu Phe Ser Val Arg Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Thr Ser Leu 20 25 30 Ser Val Pro Phe Lys Ser Lys Ser Asn His Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Arg Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asp Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Ser Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Met Asp Pro Phe 115 120 125 Gly Val Asp Arg Val Val Gln Asp Gly Ala Val Phe Arg Gln Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Ile Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Val Thr Lys Met His Ile Glu Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu 210 215 220 Ser Gly Lys Thr Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Phe His 225 230 235 240 Thr Gly Asp Ile Leu Ile Arg Ala Thr Ser Val Cys Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu 260 265 270 Leu Ala Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Tyr Gln 275 280 285 Lys Leu His Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Cys Asn Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Val Pro Thr Glu Val Phe 325 330 335 Glu Thr Gln Glu Leu Cys Gly Leu Thr Leu Glu Tyr Arg Gln Glu Cys 340 345 350 Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys 355 360 365 Glu Gly Asp Arg Ser Leu Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Ile Ala Lys Gly Arg Thr Lys Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Lys Thr Ser Asn Gly Asn Ser Ile Ser 405 <210> 165 <211> 409 <212> PRT <213> Cuphea hyssopifolia <400> 165 Met Val Ala Ala Glu Ala Ser Ser Ala Leu Phe Ser Val Arg Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Val Pro Phe Lys Ser Lys Ser Asn His Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Arg Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asp Thr Gln Glu Asp Ala Ser Ser Ser Ser 65 70 75 80 Ser Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Ser Asp Met Leu Met Asp Pro Phe 115 120 125 Gly Val Asp Arg Val Val Gln Asp Gly Val Val Phe Arg Gln Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Ile Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Val Thr Lys Met His Ile Glu Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu 210 215 220 Ser Gly Lys Thr Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Phe His 225 230 235 240 Thr Gly Asp Ile Leu Ile Arg Ala Thr Ser Val Cys Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu 260 265 270 Leu Ala Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Tyr Gln 275 280 285 Lys Leu His Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Cys Asn Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Val Pro Thr Glu Val Phe 325 330 335 Glu Thr Gln Glu Leu Cys Gly Leu Thr Leu Glu Tyr Arg Gln Glu Cys 340 345 350 Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys 355 360 365 Glu Gly Asp Arg Ser Leu Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Ile Ala Lys Gly Arg Thr Lys Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Lys Thr Ser Asn Gly Asn Ser Ile Ser 405 <210> 166 <211> 417 <212> PRT <213> Cuphea hyssopifolia <400> 166 Met Val Ala Ala Glu Ala Ser Ser Ala Leu Phe Ser Val Arg Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Thr Ser Leu 20 25 30 Ser Val Pro Phe Lys Ser Lys Ser Asn His Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Arg Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asp Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Ser Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Met Asp Pro Phe 115 120 125 Gly Val Asp Arg Val Val Gln Asp Gly Ala Val Phe Arg Gln Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Ile Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Val Thr Lys Met His Val Glu Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu 210 215 220 Ser Gly Lys Thr Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys His 225 230 235 240 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Met Cys Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu 260 265 270 Leu Ala Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Tyr Gln 275 280 285 Lys Leu His Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Cys Asn Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Val Pro Thr Glu Val Phe 325 330 335 Glu Thr Gln Glu Leu Cys Gly Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Gly Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys 355 360 365 Glu Gly Asp Arg Ser Leu Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Ala Asp Ile Ala Lys Gly Arg Thr Lys Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser Ile 405 410 415 Ser <210> 167 <211> 409 <212> PRT <213> Cuphea hyssopifolia <400> 167 Met Val Ala Ala Glu Ala Ser Ser Ala Leu Phe Ser Val Arg Thr Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Gly Asn Trp Pro Thr Ser Leu 20 25 30 Ser Val Pro Phe Lys Ser Lys Ser Asn His Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala Arg Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asp Thr Gln Glu Asp Thr Ser Ser Ser Ser 65 70 75 80 Ser Pro Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu 85 90 95 Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 100 105 110 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Met Asp Pro Phe 115 120 125 Gly Val Asp Arg Val Val Gln Asp Gly Ala Val Phe Arg Gln Ser Phe 130 135 140 Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu 145 150 155 160 Thr Leu Met Asn Ile Phe Gln Glu Thr Ser Leu Asn His Cys Lys Ser 165 170 175 Ile Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys 180 185 190 Arg Asp Leu Ile Trp Val Val Thr Lys Met His Ile Glu Val Asn Arg 195 200 205 Tyr Pro Thr Trp Gly Asp Thr Ile Glu Val Asn Thr Trp Val Ser Glu 210 215 220 Ser Gly Lys Thr Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Phe His 225 230 235 240 Thr Gly Asp Ile Leu Ile Arg Ala Thr Ser Val Cys Ala Met Met Asn 245 250 255 Gln Lys Thr Arg Arg Phe Ser Lys Phe Pro Tyr Glu Val Arg Gln Glu 260 265 270 Leu Ala Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Tyr Gln 275 280 285 Lys Leu His Lys Leu Asp Val Lys Thr Gly Asp Ser Ile Cys Asn Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Val Pro Thr Glu Val Phe 325 330 335 Glu Thr Gln Glu Leu Cys Gly Leu Thr Leu Glu Tyr Arg Gln Glu Cys 340 345 350 Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys 355 360 365 Glu Gly Asp Arg Ser Leu Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Ile Ala Lys Gly Arg Thr Lys Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Lys Thr Ser Asn Gly Asn Ser Ile Ser 405 <210> 168 <211> 415 <212> PRT <213> Cuphea calcarata <400> 168 Met Val Ala Ala Ala Ala Thr Ser Ala Phe Phe Pro Val Pro Ala Pro 1 5 10 15 Gly Thr Ser Pro Asn Pro Arg Lys Phe Gly Ser Trp Pro Ser Ser Leu 20 25 30 Ser Pro Ser Leu Pro Lys Ser Ile Pro Asn Gly Gly Phe Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Ser Leu 50 55 60 Lys Ser Gly Ser Leu Asn Thr Gln Glu Asn Thr Ser Ser Ser Pro Pro 65 70 75 80 Pro Arg Thr Phe Leu His Gln Leu Pro Asp Trp Ser Arg Leu Leu Thr 85 90 95 Ala Ile Thr Thr Val Phe Val Lys Ser Lys Arg Pro Asp Met His Asp 100 105 110 Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Leu Phe Gly Leu Glu 115 120 125 Ser Ser Val Gln Asp Ala Leu Val Phe Arg Gln Ser Phe Ser Ile Arg 130 135 140 Ser Tyr Glu Ile Gly Thr Asp Arg Thr Ala Ser Ile Glu Thr Leu Met 145 150 155 160 Asn His Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser Thr Gly Ile 165 170 175 Leu Leu Asp Gly Phe Gly Arg Thr Leu Glu Met Cys Lys Arg Glu Leu 180 185 190 Ile Trp Val Val Ile Lys Met Gln Ile Gln Val Asn Arg Tyr Pro Ala 195 200 205 Trp Gly Asp Thr Val Glu Ile Asn Thr Arg Phe Ser Arg Leu Gly Lys 210 215 220 Ile Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly Glu 225 230 235 240 Ile Leu Ile Arg Ala Thr Ser Glu Tyr Ala Met Met Asn Gln Lys Thr 245 250 255 Arg Arg Leu Ser Lys Leu Pro Tyr Glu Val His Gln Glu Ile Ala Pro 260 265 270 Leu Phe Val Asp Ser Pro Pro Val Ile Glu Asp Asn Asp Leu Lys Val 275 280 285 His Lys Phe Glu Val Lys Thr Gly Asp Ser Ile Gln Lys Gly Leu Ser 290 295 300 Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Ser Asn Val Lys 305 310 315 320 Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val Leu Glu Thr 325 330 335 Gln Glu Leu Cys Ser Leu Ala Leu Glu Tyr Arg Arg Glu Cys Gly Arg 340 345 350 Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Lys Val Gly 355 360 365 Gly Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp Gly Thr Ala 370 375 380 Ile Val Asn Gly Ile Thr Glu Trp Arg Pro Lys Asn Ala Gly Ala Asn 385 390 395 400 Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser Val Ser 405 410 415 <210> 169 <211> 414 <212> PRT <213> Cuphea hookeriana <400> 169 Met Val Ala Ala Ala Ala Thr Ser Ala Phe Phe Pro Val Pro Ala Pro 1 5 10 15 Gly Thr Ser Pro Asn Pro Arg Lys Phe Gly Ser Trp Pro Ser Ser Leu 20 25 30 Ser Pro Ser Leu Pro Asn Ser Ile Pro Asn Gly Gly Phe Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Ser Leu 50 55 60 Lys Ser Gly Ser Leu Asn Thr Gln Glu Asn Thr Ser Ser Ser Pro Pro 65 70 75 80 Pro Arg Thr Phe Leu His Gln Leu Pro Asp Trp Ser Arg Leu Leu Thr 85 90 95 Ala Ile Thr Thr Val Phe Val Lys Ser Lys Arg Pro Asp Met His Asp 100 105 110 Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Leu Phe Gly Leu Glu 115 120 125 Ser Ser Val Gln Asp Ala Leu Val Phe Arg Gln Arg Phe Ser Ile Arg 130 135 140 Ser Tyr Glu Ile Gly Thr Asp Arg Thr Ala Ser Met Glu Thr Leu Met 145 150 155 160 Asn His Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser Thr Gly Ile 165 170 175 Leu Leu Asp Gly Phe Gly Arg Thr Leu Glu Met Cys Lys Arg Glu Leu 180 185 190 Ile Trp Val Val Ile Lys Met Gln Ile Gln Val Asn Arg Tyr Pro Ala 195 200 205 Trp Gly Asp Thr Val Glu Ile Asn Thr Arg Phe Ser Arg Leu Gly Lys 210 215 220 Ile Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly Glu 225 230 235 240 Ile Leu Ile Arg Ala Thr Ser Glu Tyr Ala Met Met Asn Gln Lys Thr 245 250 255 Arg Arg Leu Ser Lys Leu Pro Tyr Glu Val Arg Gln Glu Ile Ala Pro 260 265 270 Leu Phe Val Asp Ser Pro Pro Val Ile Glu Asp Asn Asp Leu Lys Val 275 280 285 His Lys Phe Glu Val Lys Thr Gly Asp Ser Ile His Lys Gly Leu Thr 290 295 300 Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val Lys 305 310 315 320 Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu Thr 325 330 335 Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly Arg 340 345 350 Glu Ser Val Leu Glu Ser Leu Thr Ala Met Asp Pro Ser Gly Gly Gly 355 360 365 Tyr Gly Ser Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly Glu 370 375 380 Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Gly Val Ile Asn 385 390 395 400 Gly Val Val Pro Thr Gly Glu Ser Ser Pro Gly Asp Tyr Ser 405 410 <210> 170 <211> 416 <212> PRT <213> Cuphea avigera <400> 170 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Ser Val Pro Val Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Phe Arg Ile Trp Pro Ser Ser Leu 20 25 30 Ser Pro Ser Phe Lys Pro Lys Pro Ile Pro Asn Gly Gly Leu Gln Val 35 40 45 Lys Ala Asn Ser Arg Ala His Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Thr Phe Leu His Gln Leu Pro Asp Trp Ser Arg Leu Leu 85 90 95 Thr Ala Ile Thr Thr Val Phe Val Lys Ser Lys Arg Pro Asp Met His 100 105 110 Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Met Asp Ser Phe Gly Leu 115 120 125 Glu Ser Ile Val Gln Glu Gly Leu Glu Phe Arg Gln Ser Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Thr Asp Arg Thr Ala Ser Ile Glu Thr Leu 145 150 155 160 Met Asn Tyr Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser Thr Gly 165 170 175 Ile Leu Leu Asp Gly Phe Gly Arg Thr Pro Glu Met Cys Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Thr Lys Met Lys Ile Lys Val Asn Arg Tyr Pro 195 200 205 Ala Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser Arg Leu Gly 210 215 220 Lys Ile Gly Lys Gly Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Ile Arg Ala Thr Ser Ala Tyr Ala Thr Met Asn Gln Lys 245 250 255 Thr Arg Arg Leu Ser Lys Leu Pro Tyr Glu Val His Gln Glu Ile Ala 260 265 270 Pro Leu Phe Val Asp Ser Pro Pro Val Ile Glu Asp Asn Asp Leu Lys 275 280 285 Leu His Lys Phe Glu Val Lys Thr Gly Asp Ser Ile His Lys Gly Leu 290 295 300 Thr Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His Val Ser Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Ala Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Thr Lys Val 355 360 365 Gly Gly Arg Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp Gly Thr 370 375 380 Asp Ile Val Lys Cys Arg Thr Glu Trp Arg Pro Lys Asn Pro Gly Ala 385 390 395 400 Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Ser Val Ser 405 410 415 <210> 171 <211> 417 <212> PRT <213> Cuphea paucipetala <400> 171 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ala Pro 1 5 10 15 Gly Thr Ser Pro Lys Pro Gly Lys Ser Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Pro Ser Ile Lys Pro Met Ser Ile Pro Asn Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Arg Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Ser Val Gly 115 120 125 Leu Lys Ser Val Val Leu Asp Gly Leu Val Ser Arg Gln Ile Phe Ser 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His Cys Lys Ser Leu 165 170 175 Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly Met Cys Lys Asn 180 185 190 Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg Tyr 195 200 205 Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser His Ser 210 215 220 Gly Lys Ile Gly Met Ala Ser Asp Trp Leu Ile Thr Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val Arg Gln Glu Leu 260 265 270 Thr Pro His Tyr Val Asp Ser Pro His Val Ile Glu Asp Asn Asp Arg 275 280 285 Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Ser Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Ile Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Val Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Met Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Glu 355 360 365 Asp Glu Gly Arg Ser Gln Tyr Lys His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly 385 390 395 400 Thr Asn Gly Ala Ile Ser Thr Ala Lys Pro Ser Asn Gly Asn Ser Val 405 410 415 Ser <210> 172 <211> 417 <212> PRT <213> Cuphea procumbens <400> 172 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Ala Pro Ala Pro 1 5 10 15 Gly Ser Ser Pro Lys Pro Gly Lys Ser Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Pro Ser Phe Lys Ser Lys Ser Ile Pro Tyr Gly Arg Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Ser Val Gly 115 120 125 Leu Lys Asn Ile Val Arg Asp Gly Leu Val Ser Arg Gln Ser Phe Leu 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His Cys Lys Ser Leu 165 170 175 Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly Met Cys Lys Asn 180 185 190 Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg Tyr 195 200 205 Pro Ala Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser Gln Ser 210 215 220 Gly Lys Ile Gly Met Gly Ser Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val Arg Gln Glu Leu 260 265 270 Thr Pro His Phe Val Asp Ser Pro His Val Ile Glu Asp Asn Asp Arg 275 280 285 Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Ser Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Ile Glu Val Leu 325 330 335 Glu Ala Gln Glu Leu Cys Ser Leu Thr Val Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Met Asp Ser Val Leu Glu Ser Val Thr Ala Val Asp Pro Ser Glu 355 360 365 Asp Gly Gly Arg Ser Gln Tyr Asn His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Val Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Glu 385 390 395 400 Thr Asn Gly Ala Ile Ser Pro Gly Asn Thr Ser Asn Gly Asn Ser Ile 405 410 415 Ser <210> 173 <211> 415 <212> PRT <213> Cuphea procumbens <400> 173 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Ala Pro Ala Pro 1 5 10 15 Gly Ser Ser Pro Lys Pro Gly Lys Ser Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Pro Ser Phe Lys Ser Lys Ser Ile Pro Tyr Gly Arg Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Ser Val Gly 115 120 125 Leu Lys Asn Ile Val Arg Asp Gly Leu Val Ser Arg Gln Ser Phe Leu 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His Cys Lys Ser Leu 165 170 175 Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly Met Cys Lys Asn 180 185 190 Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg Tyr 195 200 205 Pro Ala Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser Gln Ser 210 215 220 Gly Lys Ile Gly Met Gly Ser Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val Arg Gln Glu Leu 260 265 270 Thr Pro His Phe Val Asp Ser Pro His Val Ile Glu Asp Asn Asp Arg 275 280 285 Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Gln Glu Cys 340 345 350 Gly Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly 355 360 365 Lys Gly Phe Gly Ser Gln Phe Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Gly Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Thr Ala Gly 385 390 395 400 Ile Asn Gly Ala Ile Ala Ser Gly Glu Thr Ser Pro Gly Asp Phe 405 410 415 <210> 174 <211> 410 <212> PRT <213> Cuphea procumbens <400> 174 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Ala Pro Ala Pro 1 5 10 15 Gly Ser Ser Pro Lys Pro Gly Lys Ser Gly Asn Trp Pro Ser Ser Leu 20 25 30 Ser Pro Ser Phe Lys Ser Lys Ser Ile Pro Tyr Gly Arg Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Ser Val Gly 115 120 125 Leu Lys Asn Ile Val Arg Asp Gly Leu Val Ser Arg Gln Ser Phe Leu 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His Cys Lys Ser Leu 165 170 175 Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly Met Cys Lys Asn 180 185 190 Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg Tyr 195 200 205 Pro Ala Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser Gln Ser 210 215 220 Gly Lys Ile Gly Met Gly Ser Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val Arg Gln Glu Leu 260 265 270 Thr Pro His Phe Val Asp Ser Pro His Val Ile Glu Asp Asn Asp Arg 275 280 285 Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu 325 330 335 Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly 355 360 365 Glu Gly Gly Tyr Gly Ser Gln Phe Gln His Leu Leu Arg Leu Glu Asp 370 375 380 Gly Gly Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 400 Gly Ile Asn Gly Val Leu Pro Thr Gly Glu 405 410 <210> 175 <211> 395 <212> PRT <213> Cuphea ignea <400> 175 Pro Gly Thr Ser Arg Lys Thr Gly Lys Phe Gly Asn Trp Pro Ser Ser 1 5 10 15 Leu Ser Pro Ser Phe Lys Pro Lys Ser Ile Pro Asn Gly Gly Phe Gln 20 25 30 Val Lys Ala Asn Ala Arg Ala His Pro Lys Ala Asn Gly Ser Ala Val 35 40 45 Ser Leu Lys Ser Val Ser Leu Asn Thr Gln Glu Asp Thr Ser Leu Ser 50 55 60 Pro Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp Arg Met Leu 65 70 75 80 Arg Thr Ala Leu Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr 85 90 95 Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp Ser Phe 100 105 110 Gly Leu Glu Ser Ile Val Gln Glu Gly Leu Val Phe Arg Gln Ser Phe 115 120 125 Ser Ile Arg Ser Tyr Glu Ile Gly Ile Asp Arg Thr Ala Ser Ile Glu 130 135 140 Thr Leu Met Asn His Leu Gln Glu Thr Ser Leu Asn Gln Cys Lys Ser 145 150 155 160 Ala Gly Ile Leu His Asp Gly Phe Gly Arg Thr Leu Glu Met Cys Lys 165 170 175 Arg Asp Leu Ile Trp Val Val Thr Lys Met Gln Ile Lys Val Asn Arg 180 185 190 Tyr Pro Ala Trp Gly Asp Thr Val Glu Ile Ser Thr Arg Phe Ser Arg 195 200 205 Leu Gly Lys Ile Gly Met Gly Arg Asp Trp Leu Ile Cys Asp Cys Asn 210 215 220 Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ala Tyr Ala Met Met Asn 225 230 235 240 Gln Lys Thr Arg Arg Leu Ser Lys Leu Pro Asn Glu Val Arg Gln Glu 245 250 255 Ile Ala Pro Leu Phe Val Asp Ser Asp Pro Val Ile Glu Glu Asn Asp 260 265 270 Met Lys Leu His Lys Phe Glu Val Lys Thr Gly Asp Ser Ile Cys Lys 275 280 285 Gly Leu Thr Pro Arg Trp Ser Asp Leu Asp Val Asn Gln His Val Ser 290 295 300 Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val 305 310 315 320 Leu Glu Thr Gln Glu Leu Cys Ser Leu Ala Leu Glu Tyr Arg Arg Glu 325 330 335 Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ser Met Asp Pro Ser 340 345 350 Lys Val Gly Gly Trp Ser Gln Tyr Gln His Leu Leu Arg Leu Glu Asp 355 360 365 Gly Ala Asp Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 370 375 380 Gly Ala Asn Gly Ala Ile Ser Thr Gly Lys Thr 385 390 395 <210> 176 <211> 405 <212> PRT <213> Cuphea calcarata <400> 176 Met Ala Thr Ala Ser Thr Phe Ser Ala Phe Asn Ala Arg Cys Gly Asp 1 5 10 15 Leu Arg Arg Ser Ala Gly Ser Gly Pro Arg Arg Pro Ala Arg Pro Leu 20 25 30 Pro Val Arg Ala Ala Ile Asn Ala Ser Ala His Pro Lys Ala Asn Gly 35 40 45 Ser Ala Val Ser Leu Lys Ser Gly Ser Leu Glu Thr Gln Glu Asp Asn 50 55 60 Ser Ser Ser Ser Arg Pro Pro Arg Thr Phe Ile Lys Gln Leu Pro Asp 65 70 75 80 Trp Ser Met Leu Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu 85 90 95 Lys Gln Trp Thr Met Phe Asp Arg Lys Ser Lys Arg Ser Asp Met Leu 100 105 110 Val Asp Pro Phe Val Val Asp Arg Ile Val Gln Asp Gly Val Leu Phe 115 120 125 Arg Gln Ser Phe Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr 130 135 140 Ala Ser Ile Glu Thr Leu Met Asn Ile Phe Gln Glu Thr Ser Leu Asn 145 150 155 160 His Cys Lys Ser Met Gly Leu Leu Tyr Glu Gly Phe Gly Arg Thr Pro 165 170 175 Glu Met Cys Lys Arg Asp Leu Ile Trp Val Val Thr Lys Ile His Ile 180 185 190 Lys Val Asn Arg Tyr Pro Thr Trp Gly Asp Thr Ile Glu Val Thr Thr 195 200 205 Trp Val Ser Glu Ser Gly Lys Asn Gly Met Gly Arg Asp Trp Leu Ile 210 215 220 Ser Asp Cys His Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp 225 230 235 240 Ala Met Met Asn Gln Thr Thr Arg Arg Leu Ser Lys Phe Pro Tyr Glu 245 250 255 Leu Arg Gln Glu Ile Ala Pro His Phe Val Asp Ser Asp Pro Val Ile 260 265 270 Glu Asp Asn Arg Arg Leu Leu Asn Phe Asp Val Lys Thr Gly Asp Ser 275 280 285 Ile Arg Lys Gly Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln 290 295 300 His Val Asn Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Val Pro 305 310 315 320 Thr Glu Val Phe Asp Thr Arg Glu Leu Cys Gly Leu Thr Leu Glu Tyr 325 330 335 Arg Gln Glu Cys Gly Arg Gly Ser Val Leu Glu Ser Val Thr Ala Met 340 345 350 Asp Pro Ser Lys Glu Gly Asp Arg Ser Leu Tyr Gln His Leu Leu Arg 355 360 365 Leu Glu Asp Gly Thr Asp Ile Val Lys Gly Arg Thr Glu Trp Arg Pro 370 375 380 Lys Asn Ala Gly Thr Asn Gly Pro Val Ser Thr Arg Lys Thr Thr Asn 385 390 395 400 Gly Ser Ser Val Ser 405 <210> 177 <211> 403 <212> PRT <213> Cuphea hookeriana <400> 177 Met Ala Thr Ala Ser Thr Phe Ser Ala Phe Asn Ala Arg Cys Gly Asp 1 5 10 15 Leu Arg Arg Ser Ala Gly Ser Gly Pro Arg Arg Pro Ala Arg Pro Leu 20 25 30 Pro Val Arg Ala Ala Ile Asn Ala Ser Ala His Pro Lys Ala Asn Gly 35 40 45 Ser Ala Val Ser Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asn Thr 50 55 60 Ser Ser Ser Pro Pro Pro Arg Thr Phe Leu His Gln Leu Pro Asp Trp 65 70 75 80 Ser Arg Leu Leu Thr Ala Ile Thr Thr Val Phe Val Lys Ser Lys Arg 85 90 95 Pro Asp Met His Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val Asp 100 105 110 Leu Phe Gly Leu Glu Ser Ser Val Gln Asp Ala Leu Val Phe Arg Gln 115 120 125 Arg Phe Ser Ile Arg Ser Tyr Glu Ile Gly Thr Asp Arg Thr Ala Ser 130 135 140 Met Glu Thr Leu Met Asn His Leu Gln Glu Thr Ser Leu Asn His Cys 145 150 155 160 Lys Ser Thr Gly Ile Leu Leu Asp Gly Phe Gly Arg Thr Leu Glu Met 165 170 175 Cys Lys Arg Glu Leu Ile Trp Val Val Ile Lys Met Gln Ile Gln Val 180 185 190 Asn Arg Tyr Pro Ala Trp Gly Asp Thr Val Glu Ile Asn Thr Arg Phe 195 200 205 Ser Arg Leu Gly Lys Ile Gly Met Gly Arg Asp Trp Leu Ile Ser Asp 210 215 220 Cys Asn Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Glu Tyr Ala Met 225 230 235 240 Met Asn Gln Lys Thr Arg Arg Leu Ser Lys Leu Pro Tyr Glu Val Arg 245 250 255 Gln Glu Ile Ala Pro Leu Phe Val Asp Ser Pro Pro Val Ile Glu Asp 260 265 270 Asn Asp Leu Lys Val His Lys Phe Glu Val Lys Thr Gly Asp Ser Ile 275 280 285 His Lys Gly Leu Thr Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His 290 295 300 Val Asn Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro 305 310 315 320 Glu Val Leu Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg 325 330 335 Arg Glu Cys Gly Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Met Asp 340 345 350 Pro Ser Gly Gly Gly Tyr Gly Ser Gln Phe Gln His Leu Leu Arg Leu 355 360 365 Glu Asp Gly Gly Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys 370 375 380 Asn Gly Val Ile Asn Gly Val Val Pro Thr Gly Glu Ser Ser Pro Gly 385 390 395 400 Asp Tyr Ser <210> 178 <211> 404 <212> PRT <213> Cuphea avigera <400> 178 Met Ala Thr Ala Ser Thr Phe Ser Ala Phe Asn Ala Arg Cys Gly Asp 1 5 10 15 Leu Arg Arg Ser Ala Gly Ser Gly Pro Arg Arg Pro Ala Arg Pro Leu 20 25 30 Pro Val Arg Ala Ala Ile Asn Ser Arg Ala His Pro Lys Ala Asn Gly 35 40 45 Ser Ala Val Ser Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr 50 55 60 Ser Ser Ser Pro Pro Pro Arg Thr Phe Leu His Gln Leu Pro Asp Trp 65 70 75 80 Ser Arg Leu Leu Thr Ala Ile Thr Thr Val Phe Val Lys Ser Lys Arg 85 90 95 Pro Asp Met His Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Met Asp 100 105 110 Ser Phe Gly Leu Glu Ser Ile Val Gln Glu Gly Leu Glu Phe Arg Gln 115 120 125 Ser Phe Ser Ile Arg Ser Tyr Glu Ile Gly Thr Asp Arg Thr Ala Ser 130 135 140 Ile Glu Thr Leu Met Asn Tyr Leu Gln Glu Thr Ser Leu Asn His Cys 145 150 155 160 Lys Ser Thr Gly Ile Leu Leu Asp Gly Phe Gly Arg Thr Pro Glu Met 165 170 175 Cys Lys Arg Asp Leu Ile Trp Val Val Thr Lys Met Lys Ile Lys Val 180 185 190 Asn Arg Tyr Pro Ala Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Phe 195 200 205 Ser Arg Leu Gly Lys Ile Gly Lys Gly Arg Asp Trp Leu Ile Ser Asp 210 215 220 Cys Asn Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ala Tyr Ala Thr 225 230 235 240 Met Asn Gln Lys Thr Arg Arg Leu Ser Lys Leu Pro Tyr Glu Val His 245 250 255 Gln Glu Ile Ala Pro Leu Phe Val Asp Ser Pro Pro Val Ile Glu Asp 260 265 270 Asn Asp Leu Lys Leu His Lys Phe Glu Val Lys Thr Gly Asp Ser Ile 275 280 285 His Lys Gly Leu Thr Pro Gly Trp Asn Asp Leu Asp Val Asn Gln His 290 295 300 Val Ser Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr 305 310 315 320 Glu Val Leu Glu Thr Gln Glu Leu Cys Ser Leu Ala Leu Glu Tyr Arg 325 330 335 Arg Glu Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp 340 345 350 Pro Thr Lys Val Gly Gly Arg Ser Gln Tyr Gln His Leu Leu Arg Leu 355 360 365 Glu Asp Gly Thr Asp Ile Val Lys Cys Arg Thr Glu Trp Arg Pro Lys 370 375 380 Asn Pro Gly Ala Asn Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly 385 390 395 400 Asn Ser Val Ser <210> 179 <211> 405 <212> PRT <213> Cuphea paucipetala <400> 179 Met Ala Thr Ala Ser Thr Phe Ser Ala Phe Asn Ala Arg Cys Gly Asp 1 5 10 15 Leu Arg Arg Ser Ala Gly Ser Gly Pro Arg Arg Pro Ala Arg Pro Leu 20 25 30 Pro Val Arg Ala Ala Ile Asn Ala Ser Ala His Pro Lys Ala Asn Gly 35 40 45 Ser Ala Val Asn Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr 50 55 60 Ser Ser Ser Pro Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp 65 70 75 80 Ser Met Leu Leu Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys 85 90 95 Gln Trp Thr Met Arg Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val 100 105 110 Asp Ser Val Gly Leu Lys Ser Val Val Leu Asp Gly Leu Val Ser Arg 115 120 125 Gln Ile Phe Ser Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala 130 135 140 Ser Ile Glu Thr Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His 145 150 155 160 Cys Lys Ser Leu Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly 165 170 175 Met Cys Lys Asn Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met 180 185 190 Val Asn Arg Tyr Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Thr Trp 195 200 205 Phe Ser His Ser Gly Lys Ile Gly Met Ala Ser Asp Trp Leu Ile Thr 210 215 220 Asp Cys Asn Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala 225 230 235 240 Met Met Asn Gln Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val 245 250 255 Arg Gln Glu Leu Thr Pro His Tyr Val Asp Ser Pro His Val Ile Glu 260 265 270 Asp Asn Asp Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser 275 280 285 Ile Arg Lys Gly Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln 290 295 300 His Val Ser Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro 305 310 315 320 Ile Glu Val Leu Glu Thr Gln Glu Leu Cys Ser Leu Thr Val Glu Tyr 325 330 335 Arg Arg Glu Cys Gly Met Asp Ser Val Leu Glu Ser Val Thr Ala Met 340 345 350 Asp Pro Ser Glu Asp Glu Gly Arg Ser Gln Tyr Lys His Leu Leu Arg 355 360 365 Leu Glu Asp Gly Thr Asp Ile Val Lys Gly Arg Thr Glu Trp Arg Pro 370 375 380 Lys Asn Ala Gly Thr Asn Gly Ala Ile Ser Thr Ala Lys Pro Ser Asn 385 390 395 400 Gly Asn Ser Val Ser 405 <210> 180 <211> 405 <212> PRT <213> Cuphea procumbens <400> 180 Met Ala Thr Ala Ser Thr Phe Ser Ala Phe Asn Ala Arg Cys Gly Asp 1 5 10 15 Leu Arg Arg Ser Ala Gly Ser Gly Pro Arg Arg Pro Ala Arg Pro Leu 20 25 30 Pro Val Arg Ala Ala Ile Asn Ala Ser Ala His Pro Lys Ala Asn Gly 35 40 45 Ser Ala Val Asn Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr 50 55 60 Ser Ser Ser Pro Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp 65 70 75 80 Ser Met Leu Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys 85 90 95 Gln Trp Thr Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val 100 105 110 Asp Ser Val Gly Leu Lys Asn Ile Val Arg Asp Gly Leu Val Ser Arg 115 120 125 Gln Ser Phe Leu Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala 130 135 140 Ser Ile Glu Thr Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His 145 150 155 160 Cys Lys Ser Leu Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly 165 170 175 Met Cys Lys Asn Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met 180 185 190 Val Asn Arg Tyr Pro Ala Trp Gly Asp Thr Val Glu Ile Asn Thr Trp 195 200 205 Phe Ser Gln Ser Gly Lys Ile Gly Met Gly Ser Asp Trp Leu Ile Ser 210 215 220 Asp Cys Asn Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala 225 230 235 240 Met Met Asn Gln Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val 245 250 255 Arg Gln Glu Leu Thr Pro His Phe Val Asp Ser Pro His Val Ile Glu 260 265 270 Asp Asn Asp Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser 275 280 285 Ile Arg Lys Gly Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln 290 295 300 His Val Ser Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro 305 310 315 320 Ile Glu Val Leu Glu Ala Gln Glu Leu Cys Ser Leu Thr Val Glu Tyr 325 330 335 Arg Arg Glu Cys Gly Met Asp Ser Val Leu Glu Ser Val Thr Ala Val 340 345 350 Asp Pro Ser Glu Asp Gly Gly Arg Ser Gln Tyr Asn His Leu Leu Arg 355 360 365 Leu Glu Asp Gly Thr Asp Val Val Lys Gly Arg Thr Glu Trp Arg Pro 370 375 380 Lys Asn Ala Glu Thr Asn Gly Ala Ile Ser Pro Gly Asn Thr Ser Asn 385 390 395 400 Gly Asn Ser Ile Ser 405 <210> 181 <211> 403 <212> PRT <213> Cuphea procumbens <400> 181 Met Ala Thr Ala Ser Thr Phe Ser Ala Phe Asn Ala Arg Cys Gly Asp 1 5 10 15 Leu Arg Arg Ser Ala Gly Ser Gly Pro Arg Arg Pro Ala Arg Pro Leu 20 25 30 Pro Val Arg Ala Ala Ile Asn Ala Ser Ala His Pro Lys Ala Asn Gly 35 40 45 Ser Ala Val Asn Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr 50 55 60 Ser Ser Ser Pro Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp 65 70 75 80 Ser Met Leu Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys 85 90 95 Gln Trp Thr Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val 100 105 110 Asp Ser Val Gly Leu Lys Asn Ile Val Arg Asp Gly Leu Val Ser Arg 115 120 125 Gln Ser Phe Leu Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala 130 135 140 Ser Ile Glu Thr Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His 145 150 155 160 Cys Lys Ser Leu Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly 165 170 175 Met Cys Lys Asn Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met 180 185 190 Val Asn Arg Tyr Pro Ala Trp Gly Asp Thr Val Glu Ile Asn Thr Trp 195 200 205 Phe Ser Gln Ser Gly Lys Ile Gly Met Gly Ser Asp Trp Leu Ile Ser 210 215 220 Asp Cys Asn Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala 225 230 235 240 Met Met Asn Gln Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val 245 250 255 Arg Gln Glu Leu Thr Pro His Phe Val Asp Ser Pro His Val Ile Glu 260 265 270 Asp Asn Asp Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser 275 280 285 Ile Arg Lys Gly Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln 290 295 300 His Val Asn Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro 305 310 315 320 Pro Glu Val Leu Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr 325 330 335 Arg Gln Glu Cys Gly Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val 340 345 350 Asp Pro Ser Gly Lys Gly Phe Gly Ser Gln Phe Gln His Leu Leu Arg 355 360 365 Leu Glu Asp Gly Gly Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro 370 375 380 Lys Thr Ala Gly Ile Asn Gly Ala Ile Ala Ser Gly Glu Thr Ser Pro 385 390 395 400 Gly Asp Phe <210> 182 <211> 398 <212> PRT <213> Cuphea procumbens <400> 182 Met Ala Thr Ala Ser Thr Phe Ser Ala Phe Asn Ala Arg Cys Gly Asp 1 5 10 15 Leu Arg Arg Ser Ala Gly Ser Gly Pro Arg Arg Pro Ala Arg Pro Leu 20 25 30 Pro Val Arg Ala Ala Ile Asn Ala Ser Ala His Pro Lys Ala Asn Gly 35 40 45 Ser Ala Val Asn Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr 50 55 60 Ser Ser Ser Pro Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp 65 70 75 80 Ser Met Leu Leu Ser Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys 85 90 95 Gln Trp Thr Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val 100 105 110 Asp Ser Val Gly Leu Lys Asn Ile Val Arg Asp Gly Leu Val Ser Arg 115 120 125 Gln Ser Phe Leu Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala 130 135 140 Ser Ile Glu Thr Leu Met Asn His Leu Gln Glu Thr Ser Ile Asn His 145 150 155 160 Cys Lys Ser Leu Gly Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Gly 165 170 175 Met Cys Lys Asn Asp Leu Ile Trp Val Leu Thr Lys Met Gln Ile Met 180 185 190 Val Asn Arg Tyr Pro Ala Trp Gly Asp Thr Val Glu Ile Asn Thr Trp 195 200 205 Phe Ser Gln Ser Gly Lys Ile Gly Met Gly Ser Asp Trp Leu Ile Ser 210 215 220 Asp Cys Asn Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Val Trp Ala 225 230 235 240 Met Met Asn Gln Lys Thr Arg Arg Phe Ser Arg Leu Pro Tyr Glu Val 245 250 255 Arg Gln Glu Leu Thr Pro His Phe Val Asp Ser Pro His Val Ile Glu 260 265 270 Asp Asn Asp Arg Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser 275 280 285 Ile Arg Lys Gly Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln 290 295 300 His Val Asn Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro 305 310 315 320 Pro Glu Val Leu Glu Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr 325 330 335 Arg Arg Glu Cys Gly Arg Glu Ser Val Leu Glu Ser Leu Thr Ala Val 340 345 350 Asp Pro Ser Gly Glu Gly Gly Tyr Gly Ser Gln Phe Gln His Leu Leu 355 360 365 Arg Leu Glu Asp Gly Gly Glu Ile Val Lys Gly Arg Thr Glu Trp Arg 370 375 380 Pro Lys Asn Ala Gly Ile Asn Gly Val Leu Pro Thr Gly Glu 385 390 395 <210> 183 <211> 398 <212> PRT <213> Cuphea ignea <400> 183 Met Ala Thr Ala Ser Thr Phe Ser Ala Phe Asn Ala Arg Cys Gly Asp 1 5 10 15 Leu Arg Arg Ser Ala Gly Ser Gly Pro Arg Arg Pro Ala Arg Pro Leu 20 25 30 Pro Val Arg Ala Ala Ile Asn Ala Arg Ala His Pro Lys Ala Asn Gly 35 40 45 Ser Ala Val Ser Leu Lys Ser Val Ser Leu Asn Thr Gln Glu Asp Thr 50 55 60 Ser Leu Ser Pro Pro Pro Arg Ala Phe Leu Asn Gln Leu Pro Asp Trp 65 70 75 80 Arg Met Leu Arg Thr Ala Leu Thr Thr Val Phe Val Ala Ala Glu Lys 85 90 95 Gln Trp Thr Met Leu Asp Arg Lys Ser Lys Arg Pro Asp Met Leu Val 100 105 110 Asp Ser Phe Gly Leu Glu Ser Ile Val Gln Glu Gly Leu Val Phe Arg 115 120 125 Gln Ser Phe Ser Ile Arg Ser Tyr Glu Ile Gly Ile Asp Arg Thr Ala 130 135 140 Ser Ile Glu Thr Leu Met Asn His Leu Gln Glu Thr Ser Leu Asn Gln 145 150 155 160 Cys Lys Ser Ala Gly Ile Leu His Asp Gly Phe Gly Arg Thr Leu Glu 165 170 175 Met Cys Lys Arg Asp Leu Ile Trp Val Val Thr Lys Met Gln Ile Lys 180 185 190 Val Asn Arg Tyr Pro Ala Trp Gly Asp Thr Val Glu Ile Ser Thr Arg 195 200 205 Phe Ser Arg Leu Gly Lys Ile Gly Met Gly Arg Asp Trp Leu Ile Cys 210 215 220 Asp Cys Asn Thr Gly Glu Ile Leu Ile Arg Ala Thr Ser Ala Tyr Ala 225 230 235 240 Met Met Asn Gln Lys Thr Arg Arg Leu Ser Lys Leu Pro Asn Glu Val 245 250 255 Arg Gln Glu Ile Ala Pro Leu Phe Val Asp Ser Asp Pro Val Ile Glu 260 265 270 Glu Asn Asp Met Lys Leu His Lys Phe Glu Val Lys Thr Gly Asp Ser 275 280 285 Ile Cys Lys Gly Leu Thr Pro Arg Trp Ser Asp Leu Asp Val Asn Gln 290 295 300 His Val Ser Asn Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro 305 310 315 320 Thr Glu Val Leu Glu Thr Gln Glu Leu Cys Ser Leu Ala Leu Glu Tyr 325 330 335 Arg Arg Glu Cys Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ser Met 340 345 350 Asp Pro Ser Lys Val Gly Gly Trp Ser Gln Tyr Gln His Leu Leu Arg 355 360 365 Leu Glu Asp Gly Ala Asp Ile Val Lys Gly Arg Thr Glu Trp Arg Pro 370 375 380 Lys Asn Ala Gly Ala Asn Gly Ala Ile Ser Thr Gly Lys Thr 385 390 395 <210> 184 <211> 414 <212> PRT <213> Cuphea glossostoma <400> 184 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Ser Pro Ala Pro 1 5 10 15 Gly Ser Ser Pro Lys Pro Gly Asn Arg Pro Ser Ser Leu Ser Pro Ser 20 25 30 Phe Lys Pro Lys Ser Ile Pro Asn Gly Ala Phe Gln Val Lys Ala Asn 35 40 45 Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn Leu Lys Ser 50 55 60 Gly Ser Leu Asn Thr Gln Glu Asp Ser Ser Ser Ser Pro Ser Pro Arg 65 70 75 80 Ala Phe Leu Asn Gln Leu Pro Asp Trp Ser Val Leu Leu Thr Ala Ile 85 90 95 Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met Leu Asp Arg 100 105 110 Lys Ser Lys Arg Pro Asp Val Leu Val Asp Ser Val Gly Leu Lys Ser 115 120 125 Ile Val Gln Asp Gly Leu Val Ser Arg Gln Ser Phe Ser Ile Arg Ser 130 135 140 Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Leu Met Asn 145 150 155 160 His Leu Gln Glu Thr Ser Ile Asn His Cys Lys Ser Leu Gly Leu Leu 165 170 175 Asn Asp Gly Phe Gly Arg Thr Pro Gly Met Cys Lys Asn Asp Leu Ile 180 185 190 Trp Val Leu Thr Lys Met Gln Ile Met Val Asn Arg Tyr Pro Ala Trp 195 200 205 Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser Gln Ser Gly Lys Ile 210 215 220 Gly Met Gly Ser Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly Glu Ile 225 230 235 240 Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln Lys Thr Arg 245 250 255 Arg Phe Ser Arg Leu Pro Tyr Glu Val Arg Gln Glu Leu Thr Pro His 260 265 270 Phe Val Asp Ser Pro His Val Ile Glu Asp Asn Asp Arg Lys Leu His 275 280 285 Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly Leu Thr Pro 290 295 300 Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Ser Asn Val Lys Tyr 305 310 315 320 Ile Gly Trp Ile Leu Glu Ser Met Pro Ile Glu Val Leu Glu Thr Gln 325 330 335 Glu Leu Cys Ser Leu Thr Val Glu Tyr Arg Arg Glu Cys Gly Met Asp 340 345 350 Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Glu Asp Gly Gly 355 360 365 Arg Ser Gln Tyr Asn His Leu Leu Arg Leu Glu Asp Gly Thr Asp Val 370 375 380 Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly Thr Asn Gly 385 390 395 400 Ala Ile Ser Thr Thr Lys Thr Ser Asn Gly Asn Ser Val Ser 405 410 <210> 185 <211> 414 <212> PRT <213> Cuphea glossostoma <400> 185 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Ser Pro Ala Pro 1 5 10 15 Gly Ser Ser Pro Lys Pro Gly Asn Arg Pro Ser Ser Leu Ser Pro Ser 20 25 30 Phe Lys Pro Lys Ser Ile Pro Asn Gly Ala Phe Gln Val Lys Ala Asn 35 40 45 Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Asn Leu Lys Ser 50 55 60 Gly Ser Leu Asn Thr Gln Glu Asp Ser Ser Ser Ser Pro Ser Pro Arg 65 70 75 80 Ala Phe Leu Asn Gln Leu Pro Asp Trp Ser Val Leu Leu Thr Ala Ile 85 90 95 Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met Leu Asp Arg 100 105 110 Lys Ser Lys Arg Pro Asp Val Leu Val Asp Ser Val Gly Leu Lys Ser 115 120 125 Ile Val Gln Asp Gly Leu Val Ser Arg Gln Ser Phe Ser Ile Arg Ser 130 135 140 Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Leu Met Asn 145 150 155 160 His Leu Gln Glu Thr Ser Ile Asn His Phe Lys Ser Leu Gly Leu Leu 165 170 175 Asn Asp Gly Phe Gly Arg Thr Pro Gly Met Cys Lys Asn Asp Leu Ile 180 185 190 Trp Val Leu Thr Lys Thr Gln Ile Met Val Asn Arg Tyr Pro Ala Trp 195 200 205 Gly Asp Thr Val Glu Ile Asn Thr Trp Phe Ser Gln Ser Gly Lys Ile 210 215 220 Gly Met Gly Ser Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly Glu Ile 225 230 235 240 Leu Ile Arg Ala Thr Ser Val Trp Ala Met Met Asn Gln Lys Thr Arg 245 250 255 Arg Phe Ser Arg Leu Pro Tyr Glu Val Arg Gln Glu Leu Thr Pro His 260 265 270 Phe Val Asp Ser Pro His Val Ile Glu Asp Asn Asp Arg Lys Leu His 275 280 285 Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly Leu Thr Pro 290 295 300 Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Ser Asn Val Lys Tyr 305 310 315 320 Ile Gly Trp Ile Leu Glu Ser Met Pro Ile Glu Val Leu Glu Thr Gln 325 330 335 Glu Leu Cys Ser Leu Thr Val Glu Tyr Arg Arg Glu Cys Gly Met Asp 340 345 350 Ser Val Leu Glu Ser Val Ser Ala Met Asp Pro Ser Glu Asp Gly Gly 355 360 365 Arg Ser Gln Tyr Asn His Leu Leu Arg Leu Glu Asp Gly Thr Asp Val 370 375 380 Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly Thr Asn Gly 385 390 395 400 Ala Ile Ser Thr Thr Lys Thr Ser Asn Gly Asn Ser Val Ser 405 410 <210> 186 <211> 434 <212> PRT <213> Umbellularia californica <400> 186 Met Val Ala Thr Ala Ala Ala Ser Ala Phe Phe Pro Val Gly Ser Pro 1 5 10 15 Ala Thr Ser Ser Ala Thr Ser Ala Lys Ala Ser Met Met Pro Asp Asn 20 25 30 Leu Asp Ala Arg Gly Ile Lys Pro Lys Pro Ala Ser Ser Ser Gly Leu 35 40 45 Gln Val Lys Ala Asn Ala His Ala Ser Pro Lys Ile Asn Gly Ser Lys 50 55 60 Val Ser Thr Asp Thr Leu Lys Gly Glu Asp Thr Leu Thr Ser Ser Pro 65 70 75 80 Ala Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Phe Leu 85 90 95 Ala Ala Ile Thr Thr Ile Phe Leu Ala Ala Glu Lys Gln Trp Thr Asn 100 105 110 Leu Asp Trp Lys Pro Arg Arg Pro Asp Met Leu Ala Asp Pro Phe Gly 115 120 125 Ile Gly Arg Phe Met Gln Asp Gly Leu Ile Phe Arg Gln His Phe Ala 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Arg Ser Ala 165 170 175 Gly Leu Leu Gly Asp Gly Phe Gly Ala Thr Pro Glu Met Ser Arg Arg 180 185 190 Asp Leu Ile Trp Val Val Thr Arg Met Gln Val Leu Val Asp Arg Tyr 195 200 205 Pro Ala Trp Gly Asp Ile Val Glu Val Glu Thr Trp Val Gly Ala Ser 210 215 220 Gly Lys Asn Gly Met Arg Arg Asp Trp Leu Val Arg Asp Ser Gln Thr 225 230 235 240 Gly Glu Ile Leu Thr Arg Ala Thr Ser Val Trp Val Met Met Asn Lys 245 250 255 Arg Thr Arg Arg Leu Ser Lys Ile Pro Glu Glu Val Arg Gly Glu Ile 260 265 270 Gly Pro Tyr Phe Met Glu Asn Val Ala Ile Ile Glu Glu Asp Ser Arg 275 280 285 Lys Leu Gln Lys Leu Asn Glu Asn Ile Ile Glu Glu Asp Ser Arg Lys 290 295 300 Leu Gln Lys Leu Asn Glu Asn Thr Ala Asp Asn Val Arg Arg Gly Leu 305 310 315 320 Thr Pro Arg Trp Ser Asp Leu Asp Val Asn Gln His Val Asn Asn Val 325 330 335 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Ala Pro Gly Ser Ile Leu Glu 340 345 350 Ser His Glu Leu Ser Cys Met Thr Leu Glu Tyr Arg Arg Glu Cys Gly 355 360 365 Lys Asp Ser Val Leu Gln Ser Met Thr Val Val Ser Gly Gly Gly Ser 370 375 380 Ala Ala Gly Gly Ser Pro Glu Ser Ser Val Glu Cys Asp His Leu Leu 385 390 395 400 Gln Leu Glu Ser Gly Pro Glu Val Val Lys Ala Arg Thr Glu Trp Arg 405 410 415 Pro Lys Ser Ala Asn Asn Pro Arg Ser Ile Leu Glu Met Pro Ala Glu 420 425 430 Ser Ser <210> 187 <211> 417 <212> PRT <213> Cuphea carthagenensis <400> 187 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Thr Thr Pro 1 5 10 15 Gly Thr Ser Arg Lys Pro Gly Lys Phe Gly Asn Trp Leu Ser Ser Leu 20 25 30 Ser Pro Pro Phe Arg Pro Lys Ser Ile Pro Ser Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Leu Asp Arg Lys Ser Lys Arg Ser Asp Met Leu Val Asp Ser Phe Gly 115 120 125 Met Glu Arg Ile Val Gln Asp Gly Leu Leu Phe Arg Gln Ser Phe Ser 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Arg Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser Ile 165 170 175 Arg Leu Leu Asn Glu Gly Phe Gly Arg Thr Pro Glu Met Cys Lys Arg 180 185 190 Asp Leu Ile Trp Val Val Thr Arg Met His Ile Met Val Asn Arg Tyr 195 200 205 Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Val Ser Gln Ser 210 215 220 Gly Lys Asn Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Ala Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Leu Ser Lys Leu Pro Tyr Glu Val Ser Gln Glu Ile 260 265 270 Ala Pro His Phe Val Asp Ser Pro Pro Val Ile Glu Asp Gly Asp Arg 275 280 285 Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val Leu 325 330 335 Glu Thr His Glu Leu Cys Phe Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Asn 355 360 365 Glu Gly Gly Arg Ser His Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Arg 385 390 395 400 Asn Ile Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Pro Ala 405 410 415 Ser <210> 188 <211> 417 <212> PRT <213> Cuphea carthagenensis <400> 188 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Thr Thr Pro 1 5 10 15 Gly Thr Ser Arg Lys Pro Gly Lys Phe Gly Asn Trp Leu Ser Ser Leu 20 25 30 Ser Pro Pro Phe Arg Pro Lys Ser Ile Pro Ser Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Leu Asp Arg Lys Ser Lys Arg Ser Asp Met Leu Val Asp Ser Phe Gly 115 120 125 Met Glu Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Ser Phe Ser 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Arg Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser Ile 165 170 175 Arg Leu Leu Asn Glu Gly Phe Gly Arg Thr Pro Glu Met Cys Lys Arg 180 185 190 Asp Leu Ile Trp Val Val Thr Arg Met His Ile Met Val Asn Arg Tyr 195 200 205 Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Val Ser Gln Ser 210 215 220 Gly Lys Asn Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Ala Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Leu Ser Lys Leu Pro Tyr Glu Val Ser Gln Glu Ile 260 265 270 Ala Pro His Phe Val Asp Ser Pro Pro Val Ile Glu Asp Gly Asp Arg 275 280 285 Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val Leu 325 330 335 Glu Thr His Glu Leu Cys Phe Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Asn 355 360 365 Glu Gly Gly Arg Ser His Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Arg 385 390 395 400 Asn Ile Gly Ala Ile Ser Thr Gly Lys Thr Ser Asn Gly Asn Pro Ala 405 410 415 Ser <210> 189 <211> 417 <212> PRT <213> Cuphea carthagenensis <400> 189 Met Val Ala Ala Ala Ala Ser Ser Ala Phe Phe Pro Val Thr Thr Pro 1 5 10 15 Gly Thr Ser Arg Lys Pro Gly Lys Phe Gly Asn Trp Leu Ser Ser Leu 20 25 30 Ser Pro Pro Phe Arg Pro Lys Ser Ile Pro Ser Gly Gly Phe Gln Val 35 40 45 Lys Ala Asn Ala Ser Ala His Pro Lys Ala Asn Gly Ser Ala Val Ser 50 55 60 Leu Lys Ser Gly Ser Leu Asn Thr Gln Glu Asp Thr Ser Ser Ser Pro 65 70 75 80 Pro Pro Arg Ala Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu 85 90 95 Thr Ala Ile Thr Thr Val Phe Val Ala Ala Glu Lys Gln Trp Thr Met 100 105 110 Leu Asp Arg Lys Ser Lys Arg Ser Asp Met Leu Val Asp Ser Phe Gly 115 120 125 Met Glu Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Ser Phe Ser 130 135 140 Ile Arg Ser Tyr Glu Ile Gly Ala Asp Arg Arg Ala Ser Ile Glu Thr 145 150 155 160 Leu Met Asn His Leu Gln Glu Thr Ser Leu Asn His Cys Lys Ser Ile 165 170 175 Arg Leu Leu Asn Glu Gly Phe Gly Arg Thr Pro Glu Met Cys Lys Arg 180 185 190 Asp Leu Ile Trp Val Phe Thr Arg Met His Ile Met Val Asn Arg Tyr 195 200 205 Pro Thr Trp Gly Asp Thr Val Glu Ile Asn Thr Trp Val Ser Gln Ser 210 215 220 Gly Lys Asn Gly Met Gly Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr 225 230 235 240 Gly Glu Ile Leu Ile Arg Ala Thr Ser Ala Trp Ala Met Met Asn Gln 245 250 255 Lys Thr Arg Arg Leu Ser Lys Leu Pro Tyr Glu Val Ser Gln Glu Ile 260 265 270 Ala Pro His Phe Val Asp Ser Pro Pro Val Ile Glu Asp Gly Asp Arg 275 280 285 Lys Leu His Lys Phe Asp Val Lys Thr Gly Asp Ser Ile Arg Lys Gly 290 295 300 Leu Thr Pro Arg Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn 305 310 315 320 Val Lys Tyr Ile Gly Trp Ile Leu Glu Ser Met Pro Thr Glu Val Leu 325 330 335 Glu Thr His Glu Leu Cys Phe Leu Thr Leu Glu Tyr Arg Arg Glu Cys 340 345 350 Gly Arg Asp Ser Val Leu Glu Ser Val Thr Ala Met Asp Pro Ser Asn 355 360 365 Glu Gly Gly Arg Ser His Tyr Gln His Leu Leu Arg Leu Glu Asp Gly 370 375 380 Thr Asp Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Arg 385 390 395 400 Asn Ile Gly Ala Ile Pro Thr Gly Lys Thr Ser Asn Gly Asn Pro Ala 405 410 415 Ser <210> 190 <211> 414 <212> PRT <213> Cuphea carthagenensis <400> 190 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Ser Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Pro Ser Ser Leu 20 25 30 Ser Pro Leu Lys Pro Lys Ser Thr Pro Asn Gly Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly Leu 50 55 60 Lys Ser Ser Ser Leu Lys Thr Gln Asp Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Thr Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Arg Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Lys Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys 355 360 365 Gly Trp Gly Ser His Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly Ile 385 390 395 400 Asn Gly Ala Val Ala Phe Glu Glu Thr Ser Pro Gly Asp Ser 405 410 <210> 191 <211> 414 <212> PRT <213> Cuphea carthagenensis <400> 191 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Ser Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Pro Ser Ser Leu 20 25 30 Ser Pro Leu Lys Pro Lys Ser Thr Pro Asn Gly Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly Leu 50 55 60 Lys Ser Ser Ser Leu Lys Thr Gln Asp Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Thr Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Ala Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Arg Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Lys Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys 355 360 365 Gly Trp Gly Ser His Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala Gly Ile 385 390 395 400 Asn Gly Ala Val Ala Phe Glu Glu Thr Ser Pro Gly Asp Ser 405 410 <210> 192 <211> 398 <212> PRT <213> Cuphea carthagenensis <400> 192 Met Val Ala Thr Ala Ala Ser Ser Ala Phe Phe Pro Val Pro Ser Pro 1 5 10 15 Asp Ser Ser Ser Arg Pro Gly Lys Leu Gly Asn Gly Pro Ser Ser Leu 20 25 30 Ser Pro Leu Lys Pro Lys Ser Thr Pro Asn Gly Gly Leu Gln Val Lys 35 40 45 Ala Asn Ala Ser Ala Pro Pro Lys Ile Asn Gly Ser Ser Val Gly Leu 50 55 60 Lys Ser Ser Ser Leu Lys Thr Gln Asp Asp Thr Pro Ser Ala Pro Pro 65 70 75 80 Pro Arg Thr Phe Ile Asn Gln Leu Pro Asp Trp Ser Met Leu Leu Ala 85 90 95 Ala Ile Thr Thr Val Phe Leu Ala Ala Glu Lys Gln Trp Met Met Leu 100 105 110 Asp Trp Lys Pro Lys Arg Pro Asp Met Leu Thr Asp Pro Phe Gly Leu 115 120 125 Gly Arg Ile Val Gln Asp Gly Leu Val Phe Arg Gln Asn Phe Ser Ile 130 135 140 Arg Ser Tyr Glu Ile Gly Ala Asp Arg Thr Ala Ser Ile Glu Thr Val 145 150 155 160 Met Asn His Leu Gln Glu Thr Ala Leu Asn His Val Lys Ser Ala Gly 165 170 175 Leu Leu Asn Asp Gly Phe Gly Arg Thr Pro Glu Met Tyr Lys Arg Asp 180 185 190 Leu Ile Trp Val Val Ala Lys Met Gln Val Met Val Asn Arg Tyr Pro 195 200 205 Thr Trp Gly Asp Thr Val Glu Val Asn Thr Trp Val Ala Lys Ser Gly 210 215 220 Lys Asn Gly Met Arg Arg Asp Trp Leu Ile Ser Asp Cys Asn Thr Gly 225 230 235 240 Glu Ile Leu Thr Arg Ala Ser Ser Val Trp Val Met Met Asn Gln Lys 245 250 255 Thr Arg Arg Leu Ser Lys Ile Pro Asp Glu Val Arg His Glu Ile Glu 260 265 270 Pro His Phe Val Asp Ser Ala Pro Val Ile Glu Asp Asp Asp Arg Lys 275 280 285 Leu Pro Lys Leu Asp Glu Lys Thr Ala Asp Ser Ile Arg Lys Gly Leu 290 295 300 Thr Pro Lys Trp Asn Asp Leu Asp Val Asn Gln His Val Asn Asn Val 305 310 315 320 Lys Tyr Ile Gly Trp Ile Leu Glu Ser Thr Pro Pro Glu Val Leu Glu 325 330 335 Thr Gln Glu Leu Cys Ser Leu Thr Leu Glu Tyr Arg Arg Glu Cys Gly 340 345 350 Lys Glu Ser Val Leu Glu Ser Leu Thr Ala Val Asp Pro Ser Gly Lys 355 360 365 Gly Trp Gly Ser His Phe Gln His Leu Leu Arg Leu Glu Asp Gly Gly 370 375 380 Glu Ile Val Lys Gly Arg Thr Glu Trp Arg Pro Lys Asn Ala 385 390 395 <210> 193 <211> 4 <212> PRT <213> Unknown <220> <223> Description of Unknown: N-terminal hydrophobic domain peptide <400> 193 Leu Pro Asp Trp 1 <210> 194 <211> 6541 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 194 gctcttcgcc gccgccactc ctgctcgagc gcgcccgcgc gtgcgccgcc agcgccttgg 60 ccttttcgcc gcgctcgtgc gcgtcgctga tgtccatcac caggtccatg aggtctgcct 120 tgcgccggct gagccactgc ttcgtccggg cggccaagag gagcatgagg gaggactcct 180 ggtccagggt cctgacgtgg tcgcggctct gggagcgggc cagcatcatc tggctctgcc 240 gcaccgaggc cgcctccaac tggtcctcca gcagccgcag tcgccgccga ccctggcaga 300 ggaagacagg tgaggggggt atgaattgta cagaacaacc acgagccttg tctaggcaga 360 atccctacca gtcatggctt tacctggatg acggcctgcg aacagctgtc cagcgaccct 420 cgctgccgcc gcttctcccg cacgcttctt tccagcaccg tgatggcgcg agccagcgcc 480 gcacgctggc gctgcgcttc gccgatctga ggacagtcgg ggaactctga tcagtctaaa 540 cccccttgcg cgttagtgtt gccatccttt gcagaccggt gagagccgac ttgttgtgcg 600 ccacccccca caccacctcc tcccagacca attctgtcac ctttttggcg aaggcatcgg 660 cctcggcctg cagagaggac agcagtgccc agccgctggg ggttggcgga tgcacgctca 720 ggtacccttt cttgcgctat gacacttcca gcaaaaggta gggcgggctg cgagacggct 780 tcccggcgct gcatgcaaca ccgatgatgc ttcgaccccc cgaagctcct tcggggctgc 840 atgggcgctc cgatgccgct ccagggcgag cgctgtttaa atagccaggc ccccgattgc 900 aaagacatta tagcgagcta ccaaagccat attcaaacac ctagatcact accacttcta 960 cacaggccac tcgagcttgt gatcgcactc cgctaagggg gcgcctcttc ctcttcgttt 1020 cagtcacaac ccgcaaacgg cgcgccatgc tgctgcaggc cttcctgttc ctgctggccg 1080 gcttcgccgc caagatcagc gcctccatga cgaacgagac gtccgaccgc cccctggtgc 1140 acttcacccc caacaagggc tggatgaacg accccaacgg cctgtggtac gacgagaagg 1200 acgccaagtg gcacctgtac ttccagtaca acccgaacga caccgtctgg gggacgccct 1260 tgttctgggg ccacgccacg tccgacgacc tgaccaactg ggaggaccag cccatcgcca 1320 tcgccccgaa gcgcaacgac tccggcgcct tctccggctc catggtggtg gactacaaca 1380 acacctccgg cttcttcaac gacaccatcg acccgcgcca gcgctgcgtg gccatctgga 1440 cctacaacac cccggagtcc gaggagcagt acatctccta cagcctggac ggcggctaca 1500 ccttcaccga gtaccagaag aaccccgtgc tggccgccaa ctccacccag ttccgcgacc 1560 cgaaggtctt ctggtacgag ccctcccaga agtggatcat gaccgcggcc aagtcccagg 1620 actacaagat cgagatctac tcctccgacg acctgaagtc ctggaagctg gagtccgcgt 1680 tcgccaacga gggcttcctc ggctaccagt acgagtgccc cggcctgatc gaggtcccca 1740 ccgagcagga ccccagcaag tcctactggg tgatgttcat ctccatcaac cccggcgccc 1800 cggccggcgg ctccttcaac cagtacttcg tcggcagctt caacggcacc cacttcgagg 1860 ccttcgacaa ccagtcccgc gtggtggact tcggcaagga ctactacgcc ctgcagacct 1920 tcttcaacac cgacccgacc tacgggagcg ccctgggcat cgcgtgggcc tccaactggg 1980 agtactccgc cttcgtgccc accaacccct ggcgctcctc catgtccctc gtgcgcaagt 2040 tctccctcaa caccgagtac caggccaacc cggagacgga gctgatcaac ctgaaggccg 2100 agccgatcct gaacatcagc aacgccggcc cctggagccg gttcgccacc aacaccacgt 2160 tgacgaaggc caacagctac aacgtcgacc tgtccaacag caccggcacc ctggagttcg 2220 agctggtgta cgccgtcaac accacccaga cgatctccaa gtccgtgttc gcggacctct 2280 ccctctggtt caagggcctg gaggaccccg aggagtacct ccgcatgggc ttcgaggtgt 2340 ccgcgtcctc cttcttcctg gaccgcggga acagcaaggt gaagttcgtg aaggagaacc 2400 cctacttcac caaccgcatg agcgtgaaca accagccctt caagagcgag aacgacctgt 2460 cctactacaa ggtgtacggc ttgctggacc agaacatcct ggagctgtac ttcaacgacg 2520 gcgacgtcgt gtccaccaac acctacttca tgaccaccgg gaacgccctg ggctccgtga 2580 acatgacgac gggggtggac aacctgttct acatcgacaa gttccaggtg cgcgaggtca 2640 agtgacaatt ggcagcagca gctcggatag tatcgacaca ctctggacgc tggtcgtgtg 2700 atggactgtt gccgccacac ttgctgcctt gacctgtgaa tatccctgcc gcttttatca 2760 aacagcctca gtgtgtttga tcttgtgtgt acgcgctttt gcgagttgct agctgcttgt 2820 gctatttgcg aataccaccc ccagcatccc cttccctcgt ttcatatcgc ttgcatccca 2880 accgcaactt atctacgctg tcctgctatc cctcagcgct gctcctgctc ctgctcactg 2940 cccctcgcac agccttggtt tgggctccgc ctgtattctc ctggtactgc aacctgtaaa 3000 ccagcactgc aatgctgatg cacgggaagt agtgggatgg gaacacaaat ggaaagctgt 3060 atagggataa gaattcggcc gacaggacgc gcgtcaaagg tgctggtcgt gtatgccctg 3120 gccggcaggt cgttgctgct gctggttagt gattccgcaa ccctgatttt ggcgtcttat 3180 tttggcgtgg caaacgctgg cgcccgcgag ccgggccggc ggcgatgcgg tgccccacgg 3240 ctgccggaat ccaagggagg caagagcgcc cgggtcagtt gaagggcttt acgcgcaagg 3300 tacagccgct cctgcaaggc tgcgtggtgg aattggacgt gcaggtcctg ctgaagttcc 3360 tccaccgcct caccagcgga caaagcaccg gtgtatcagg tccgtgtcat ccactctaaa 3420 gaactcgact acgacctact gatggcccta gattcttcat caaaaacgcc tgagacactt 3480 gcccaggatt gaaactccct gaagggacca ccaggggccc tgagttgttc cttccccccg 3540 tggcgagctg ccagccaggc tgtacctgtg atcgaggctg gcgggaaaat aggcttcgtg 3600 tgctcaggtc atgggaggtg caggacagct catgaaacgc caacaatcgc acaattcatg 3660 tcaagctaat cagctatttc ctcttcacga gctgtaattg tcccaaaatt ctggtctacc 3720 gggggtgatc cttcgtgtac gggcccttcc ctcaacccta ggtatgcgcg catgcggtcg 3780 ccgcgcaact cgcgcgaggg ccgagggttt gggacgggcc gtcccgaaat gcagttgcac 3840 ccggatgcgt ggcacctttt ttgcgataat ttatgcaatg gactgctctg caaaattctg 3900 gctctgtcgc caaccctagg atcagcggcg taggatttcg taatcattcg tcctgatggg 3960 gagctaccga ctaccctaat atcagcccga ctgcctgacg ccagcgtcca cttttgtgca 4020 cacattccat tcgtgcccaa gacatttcat tgtggtgcga agcgtcccca gttacgctca 4080 cctgtttccc gacctcctta ctgttctgtc gacagagcgg gcccacaggc cggtcgcagc 4140 cactagtatg gccaccacct ccctggcctc cgccttctgc tccatgaagg ccgtgatgct 4200 ggcccgcgac ggccgcggcc tgaagccccg ctcctccgac ctgcagctgc gcgccggcaa 4260 cgcccagacc tccctgaaga tgatcaacgg caccaagttc tcctacaccg agtccctgaa 4320 gaagctgccc gactggtcca tgctgttcgc cgtgatcacc accatcttct ccgccgccga 4380 gaagcagtgg accaacctgg agtggaagcc caagcccaac cccccccagc tgctggacga 4440 ccacttcggc ccccacggcc tggtgttccg ccgcaccttc gccatccgct cctacgaggt 4500 gggccccgac cgctccacct ccatcgtggc cgtgatgaac cacctgcagg aggccgccct 4560 gaaccacgcc aagtccgtgg gcatcctggg cgacggcttc ggcaccaccc tggagatgtc 4620 caagcgcgac ctgatctggg tggtgaagcg cacccacgtg gccgtggagc gctaccccgc 4680 ctggggcgac accgtggagg tggagtgctg ggtgggcgcc tccggcaaca acggccgccg 4740 ccacgacttc ctggtgcgcg actgcaagac cggcgagatc ctgacccgct gcacctccct 4800 gtccgtgatg atgaacaccc gcacccgccg cctgtccaag atccccgagg aggtgcgcgg 4860 cgagatcggc cccgccttca tcgacaacgt ggccgtgaag gacgaggaga tcaagaagcc 4920 ccagaagctg aacgactcca ccgccgacta catccagggc ggcctgaccc cccgctggaa 4980 cgacctggac atcaaccagc acgtgaacaa catcaagtac gtggactgga tcctggagac 5040 cgtgcccgac tccatcttcg agtcccacca catctcctcc ttcaccatcg agtaccgccg 5100 cgagtgcacc cgcgactccg tgctgcagtc cctgaccacc gtgtccggcg gctcctccga 5160 ggccggcctg gtgtgcgagc acctgctgca gctggagggc ggctccgagg tgctgcgcgc 5220 caagaccgag tggcgcccca agctgtcctt ccgcggcatc tccgtgatcc ccgccgagtc 5280 ctccgtgatg gactacaagg accacgacgg cgactacaag gaccacgaca tcgactacaa 5340 ggacgacgac gacaagtgac tcgaggcagc agcagctcgg atagtatcga cacactctgg 5400 acgctggtcg tgtgatggac tgttgccgcc acacttgctg ccttgacctg tgaatatccc 5460 tgccgctttt atcaaacagc ctcagtgtgt ttgatcttgt gtgtacgcgc ttttgcgagt 5520 tgctagctgc ttgtgctatt tgcgaatacc acccccagca tccccttccc tcgtttcata 5580 tcgcttgcat cccaaccgca acttatctac gctgtcctgc tatccctcag cgctgctcct 5640 gctcctgctc actgcccctc gcacagcctt ggtttgggct ccgcctgtat tctcctggta 5700 ctgcaacctg taaaccagca ctgcaatgct gatgcacggg aagtagtggg atgggaacac 5760 aaatggaaag ctgtataggg ataacagggt aatgagctct tgttttccag aaggagttgc 5820 tccttgagcc tttcattctc agcctcgata acctccaaag ccgctctaat tgtggagggg 5880 gttcgaattt aaaagcttgg aatgttggtt cgtgcgtctg gaacaagccc agacttgttg 5940 ctcactggga aaaggaccat cagctccaaa aaacttgccg ctcaaaccgc gtacctctgc 6000 tttcgcgcaa tctgccctgt tgaaatcgcc accacattca tattgtgacg cttgagcagt 6060 ctgtaattgc ctcagaatgt ggaatcatct gccccctgtg cgagcccatg ccaggcatgt 6120 cgcgggcgag gacacccgcc actcgtacag cagaccatta tgctacctca caatagttca 6180 taacagtgac catatttctc gaagctcccc aacgagcacc tccatgctct gagtggccac 6240 cccccggccc tggtgcttgc ggagggcagg tcaaccggca tggggctacc gaaatccccg 6300 accggatccc accacccccg cgatgggaag aatctctccc cgggatgtgg gcccaccacc 6360 agcacaacct gctggcccag gcgagcgtca aaccatacca cacaaatatc cttggcatcg 6420 gccctgaatt ccttctgccg ctctgctacc cggtgcttct gtccgaagca ggggttgcta 6480 gggatcgctc cgagtccgca aacccttgtc gcgtggcggg gcttgttcga gcttgaagag 6540 c 6541

Claims (24)

  1. 조절 요소 및 핵산 구성체를 발현하는 세포에 의해 생산된 오일에서 변경된 지방산 프로파일을 생성하기 위해 이용 가능한 활성 아실-ACP 티오에스테라아제를 발현하는 FatB 유전자를 포함하는 핵산 구성체로서, 이때, FatB 유전자는 표 1a의 클레드 5에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 상기 서열은 서열 번호 88, 82, 85 및 103 각각과 적어도 94.6% 서열 동일성을 나타내고, 선택적으로는 상기 오일의 지방산은 C8 및 C10 지방산이 강화되는 것인, 핵산 구성체.
  2. 조절 요소 및 핵산 구성체를 발현하는 세포에 의해 생산된 오일에서 변경된 지방산 프로파일을 생성하기 위해 이용 가능한 활성 아실-ACP 티오에스테라아제를 발현하는 FatB 유전자를 포함하는 핵산 구성체로서, 이때, FatB 유전자는 표 1a의 클레드 1-12 중 하나에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하는 것인, 핵산 구성체.
  3. 제2항에 있어서, FatB 유전자는 표 1a의 클레드 1에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 상기 서열은 서열 번호 19, 161, 22 및 160 각각과 적어도 85.9% 서열 동일성을 나타내고, 선택적으로는 상기 오일의 지방산은 C14 및 C16 지방산이 강화되는 것인, 핵산 구성체.
  4. 제2항에 있어서, FatB 유전자는 표 1a의 클레드 2에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 상기 서열은 서열 번호 134-136, 132, 133, 137, 124, 122, 123, 125 각각과 적어도 89.5% 서열 동일성을 나타내고, 선택적으로는 상기 오일의 지방산은 C12 및 C14 지방산이 강화되는 것인, 핵산 구성체.
  5. 제2항에 있어서, FatB 유전자는 표 1a의 클레드 3에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 상기 서열은 서열 번호 126 및 127 각각과 적어도 92.5% 서열 동일성을 나타내고, 선택적으로는 상기 오일의 지방산은 C12 및 C14 지방산이 강화되는 것인, 핵산 구성체.
  6. 제2항에 있어서, FatB 유전자는 표 1a의 클레드 4에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 상기 서열은 서열 번호 79와 적어도 83.8% 서열 동일성을 나타내고, 선택적으로는 상기 오일의 지방산은 C12 및 C14 지방산이 강화되는 것인, 핵산 구성체.
  7. 제2항에 있어서, FatB 유전자는 표 1a의 클레드 6에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 상기 서열은 서열 번호 111 및 110과 적어도 99.9% 서열 동일성을 나타내고, 선택적으로는 상기 오일의 지방산은 C10 지방산이 강화되는 것인, 핵산 구성체.
  8. 제2항에 있어서, FatB 유전자는 표 1a의 클레드 7에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 상기 서열은 서열 번호 73, 106, 185, 172, 171, 173, 174 각각과 적어도 89.5% 서열 동일성을 나타내고, 선택적으로는 상기 오일의 지방산은 C10 및 C12 지방산이 강화되는 것인, 핵산 구성체.
  9. 제2항에 있어서, FatB 유전자는 표 1a의 클레드 8에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 상기 서열은 서열 번호 112, 113, 142, 145, 143, 144, 139, 140, 138, 141 각각과 적어도 85.9% 서열 동일성을 나타내고, 선택적으로는 상기 오일의 지방산은 C12 및 C14 지방산이 강화되는 것인, 핵산 구성체.
  10. 제2항에 있어서, FatB 유전자는 표 1a의 클레드 9에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 상기 서열은 서열 번호 187-189 각각과 적어도 83.8% 서열 동일성을 나타내고, 선택적으로는 상기 오일의 지방산은 C12 및 C14 지방산이 강화되는 것인, 핵산 구성체.
  11. 제2항에 있어서, FatB 유전자는 표 1a의 클레드 10에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 상기 서열은 서열 번호 147, 149, 146, 150, 152, 151, 148, 154, 156, 155, 157, 108, 75, 190, 191 및 192 각각과 적어도 95.9% 서열 동일성을 나타내고, 선택적으로는 상기 오일의 지방산은 C14 및 C16 지방산이 강화되는 것인, 핵산 구성체.
  12. 제2항에 있어서, FatB 유전자는 표 1a의 클레드 11에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 상기 서열은 서열 번호 121과 적어도 88.7% 서열 동일성을 나타내고, 선택적으로는 상기 오일의 지방산은 C14 및 C16 지방산이 강화되는 것인, 핵산 구성체.
  13. 제2항에 있어서, FatB 유전자는 표 1a의 클레드 12에 속하는 아미노산 서열을 가지고 있는 단백질을 발현하며, 상기 서열은 서열 번호 129 및 186과 적어도 72.8% 서열 동일성을 나타내고, 선택적으로는 상기 오일의 지방산은 C16 지방산이 강화되는 것인, 핵산 구성체.
  14. 분리된 핵산 또는 핵산을 포함하는 재조합 DNA 구성체로서, 이때, 핵산은 서열 번호 2, 3, 5, 6, 8, 9, 11, 12, 14, 15, 17, 18, 20, 21, 23, 24, 26, 27, 29, 30, 32, 33, 35, 36, 38, 39, 41, 42, 44, 45, 47, 48, 50, 51, 53, 54, 56, 57, 59, 60, 62, 63, 65, 66, 68, 69, 71, 72, 74, 76, 78, 80, 81, 83, 84, 86, 87, 89, 90, 92, 93, 95, 96, 98, 99, 101, 102, 104, 105, 107, 109 또는 유전자 암호의 축중에 의한 임의의 균등한 서열들 중 임의의 것과 적어도 70% 서열 동일성을 나타내는 것인, 분리된 핵산 또는 핵산을 포함하는 재조합 DNA 구성체.
  15. 단백질을 암호화하는 분리된 핵산, 또는 서열 번호 1, 4, 7, 10, 13, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 73, 75, 77, 79, 82, 85, 88, 91, 94, 97, 100, 103, 106, 108, 110-192 중 어느 것과 적어도 70% 서열 동일성을 나타내는 단백질 또는 아실-ACP 티오에스테라아제 활성을 가지고 있는 이의 단편을 발현하는 숙주 세포.
  16. 제15항에 있어서, 단백질은 그 서열을 포함하는 재조합 세포에 의해 생성된 오일의 지방산 프로파일을 변경하기 위해 이용 가능한 아실-ACP 티오에스테라아제 활성이 있는 것인, 분리된 핵산.
  17. 변경된 지방산 프로파일을 생성하는 재조합 세포를 생산하는 방법으로, 제1항 내지 제3항 중 어느 한 항에 따른 핵산으로 세포를 형질전환하는 것을 포함하는 방법.
  18. 제17항의 방법에 의해 생산된 숙주 세포.
  19. 제18항에 있어서, 숙주 세포는 식물 세포, 미생물 세포 및 미세조류 세포로부터 선택되는 것인 숙주 세포.
  20. 오일 또는 오일 유래 생성물을 생산하는 방법으로, 상기 방법은 제5항 또는 제6항의 숙주 세포를 배양하는 것 및 그에 의해 생산된 오일을 추출하는 것을 포함하며, 선택적으로, 이때, 배양은 당에서의 종속 영양성 성장인 것인, 방법.
  21. 제20항에 있어서, 상기 오일로부터 지방산, 연료, 화학물질, 또는 기타 오일 유래 생성물을 생산하는 것을 더 포함하는 방법.
  22. 제20항의 방법에 의해 생산된 오일로서, 선택적으로 적어도 20%의 C8, C10, C12, C14 또는 C16 지방산을 포함하는 지방산 프로파일을 나타내는 오일.
  23. 제21항의 방법에 의해 생산된 오일 유래 생성물.
  24. 제23항에 있어서, 상기 오일은 미세조류에 의해 생산되고, 선택적으로 C24-알파 스테롤이 없는 오일.
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