KR20150033679A - 페닐 트리아졸 유도체 및 이의 gabaa 수용체 복합체 조절용 용도 - Google Patents
페닐 트리아졸 유도체 및 이의 gabaa 수용체 복합체 조절용 용도 Download PDFInfo
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- KR20150033679A KR20150033679A KR20157001895A KR20157001895A KR20150033679A KR 20150033679 A KR20150033679 A KR 20150033679A KR 20157001895 A KR20157001895 A KR 20157001895A KR 20157001895 A KR20157001895 A KR 20157001895A KR 20150033679 A KR20150033679 A KR 20150033679A
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- Prior art keywords
- pain
- disorder
- disorders
- disease
- gaba
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
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- A—HUMAN NECESSITIES
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- A61K31/50—Pyridazines; Hydrogenated pyridazines
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| PCT/EP2013/063194 WO2014001282A1 (en) | 2012-06-26 | 2013-06-25 | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| BR102019014802A2 (pt) * | 2018-07-20 | 2020-02-04 | Boehringer Ingelheim Int | difluorometil-fenil triazóis |
| PH12022552340A1 (en) | 2020-03-26 | 2023-11-29 | Richter Gedeon Nyrt | APHTHYRIDINE AND PYRIDO[3,4-c]PYRIDAZINE DERIVATIVES AS GABAA a5 RECEPTOR MODULATORS |
| JP7739336B2 (ja) * | 2020-05-13 | 2025-09-16 | エフ． ホフマン－ラ ロシュ アーゲー | Ｇａｂａ ａ ａｌｐｈａ５ ｐａｍとしての新規トリアゾリル誘導体 |
| EP3992188A1 (en) * | 2020-10-29 | 2022-05-04 | Boehringer Ingelheim International GmbH | Difluoromethyl-pyridin-2-yl triazoles |
| HU231691B1 (hu) | 2021-09-29 | 2025-10-28 | Richter Gedeon Nyrt | GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok |
| CN116462664B (zh) * | 2022-03-08 | 2025-07-01 | 上海赛默罗生物科技有限公司 | 吡唑环类化合物、其制备方法、组合物及应用 |
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| CA2394654A1 (en) | 1999-12-17 | 2001-06-21 | Manfred Weigele | Proton pump inhibitors |
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| GB2378180B8 (en) | 2001-06-27 | 2009-10-21 | Cyclacel Ltd | New purine derivatives |
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| MXPA06001758A (es) | 2003-08-15 | 2006-08-11 | Irm Llc | Anilino purinas sustituidas en la posicion 6 utiles como inhibidores de rtk. |
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| TW200538120A (en) | 2004-02-20 | 2005-12-01 | Kirin Brewery | Compound having TGF-beta inhibitory activity and pharmaceutical composition containing same |
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| ATE537171T1 (de) | 2005-12-27 | 2011-12-15 | Hoffmann La Roche | Aryl-isoxazol-4-yl-imidazoä1,5-aüpyridin-deriva e |
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| EP1894924A1 (en) | 2006-08-29 | 2008-03-05 | Phenex Pharmaceuticals AG | Heterocyclic FXR binding compounds |
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| NZ579248A (en) | 2007-03-28 | 2011-08-26 | Neurosearch As | Purinyl derivatives and their use as potassium channel modulators |
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| PT2767536E (pt) | 2007-12-04 | 2015-11-17 | Hoffmann La Roche | Derivados de isoxazolo-piridina |
| EP2229383B1 (en) | 2007-12-04 | 2017-01-18 | F. Hoffmann-La Roche AG | Isoxazolo-pyrazine derivatives |
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| IL235991A0 (en) | 2015-02-01 |
| US20160115155A1 (en) | 2016-04-28 |
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| US9884848B2 (en) | 2018-02-06 |
| US20170114045A1 (en) | 2017-04-27 |
| EP2885290B1 (en) | 2017-10-18 |
| RU2014149123A (ru) | 2016-08-20 |
| WO2014001282A1 (en) | 2014-01-03 |
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