IN2014DN11027A - - Google Patents
Info
- Publication number
- IN2014DN11027A IN2014DN11027A IN11027DEN2014A IN2014DN11027A IN 2014DN11027 A IN2014DN11027 A IN 2014DN11027A IN 11027DEN2014 A IN11027DEN2014 A IN 11027DEN2014A IN 2014DN11027 A IN2014DN11027 A IN 2014DN11027A
- Authority
- IN
- India
- Prior art keywords
- compound
- treatment
- subunit
- disorders
- responsive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
This invention relates to a novel phenyl triazole derivative pharmaceutical compositions containing this compound and methods of treatment therewith. The compound of the invention is in particular considered useful for the treatment of central nervous system diseases and disorders which are responsive to modulation of GABA receptors containing the α5 subunit.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261664288P | 2012-06-26 | 2012-06-26 | |
DKPA201270369 | 2012-06-26 | ||
PCT/EP2013/063194 WO2014001282A1 (en) | 2012-06-26 | 2013-06-25 | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014DN11027A true IN2014DN11027A (en) | 2015-09-25 |
Family
ID=49782300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN11027DEN2014 IN2014DN11027A (en) | 2012-06-26 | 2013-06-25 |
Country Status (13)
Country | Link |
---|---|
US (2) | US9475797B2 (en) |
EP (1) | EP2885290B1 (en) |
JP (1) | JP6223443B2 (en) |
KR (1) | KR20150033679A (en) |
CN (1) | CN104411703A (en) |
AU (1) | AU2013283488A1 (en) |
BR (1) | BR112014032501A2 (en) |
CA (1) | CA2876780A1 (en) |
IL (1) | IL235991A (en) |
IN (1) | IN2014DN11027A (en) |
MX (1) | MX2014014872A (en) |
RU (1) | RU2014149123A (en) |
WO (1) | WO2014001282A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR102019014802A2 (en) | 2018-07-20 | 2020-02-04 | Boehringer Ingelheim Int | difluoromethyl-phenyl triazoles |
TW202202495A (en) | 2020-03-26 | 2022-01-16 | 匈牙利商羅特格登公司 | Naphthyridine and pyrido〔3,4-c〕pyridazine derivatives as gamma-aminobutyric acid a receptor subunit alpha 5 receptor modulators |
CN115461337A (en) * | 2020-05-13 | 2022-12-09 | 豪夫迈·罗氏有限公司 | Novel triazolyl derivatives as GABA A alpha 5 PAM |
HUP2100338A1 (en) | 2021-09-29 | 2023-04-28 | Richter Gedeon Nyrt | Bicyclic amine derivatives as gabaa alfa5 receptor modulators |
Family Cites Families (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69627195T2 (en) | 1995-11-01 | 2004-01-29 | Novartis Ag | PURINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
FR2741881B1 (en) | 1995-12-01 | 1999-07-30 | Centre Nat Rech Scient | NOVEL PURINE DERIVATIVES HAVING IN PARTICULAR ANTI-PROLIFERATIVE PRORIETES AND THEIR BIOLOGICAL APPLICATIONS |
BR9813835A (en) | 1997-12-22 | 2000-10-10 | Du Pont Pharm Co | Compound, pharmaceutical composition and method of treatment or prevention of a thromboembolic disorder |
DE19834044A1 (en) | 1998-07-29 | 2000-02-03 | Bayer Ag | New substituted pyrazole derivatives |
WO2001044260A2 (en) | 1999-12-17 | 2001-06-21 | Ariad Pharmaceuticals, Inc. | Novel purines |
IL150062A0 (en) | 1999-12-17 | 2002-12-01 | Ariad Pharma Inc | Proton pump inhibitors |
AU2441701A (en) | 1999-12-17 | 2001-06-25 | Ariad Pharmaceuticals, Inc. | Purine derivatives |
WO2003002565A1 (en) | 2001-06-27 | 2003-01-09 | Cyclacel Limited | 2,6,9-substituted purine derivatives and their use n the treatment of proliferative disorders |
US20030078232A1 (en) | 2001-08-08 | 2003-04-24 | Elfatih Elzein | Adenosine receptor A3 agonists |
US7262176B2 (en) | 2001-08-08 | 2007-08-28 | Cv Therapeutics, Inc. | Adenosine A3 receptor agonists |
CA2463563A1 (en) | 2001-10-12 | 2003-04-17 | Irm Llc | Kinase inhibitor scaffolds and methods for their preparation |
US20060009642A1 (en) | 2001-10-12 | 2006-01-12 | Irm Llc, A Delaware Limited Liability Company | Methods for the synthesis of substituted purines |
US20030229105A1 (en) | 2002-05-21 | 2003-12-11 | Cyclacel Limited | Treatment of autoimmune disorders |
US20030139427A1 (en) | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
WO2004021979A2 (en) | 2002-09-06 | 2004-03-18 | Smithkline Beecham Corporation | PYRROLO[2, 3-d]PYRIMIDINE-4-YL AND PURIN-6-YL UREA COMPOUNDS |
SG145748A1 (en) | 2003-08-15 | 2008-09-29 | Irm Llc | 6-substituted anilino purines as rtk inhibitors |
WO2005067546A2 (en) | 2004-01-13 | 2005-07-28 | Ambit Biosciences Corporation | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases |
WO2005080377A1 (en) | 2004-02-20 | 2005-09-01 | Kirin Beer Kabushiki Kaisha | COMPOUND HAVING TGF-β INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME |
GB0407723D0 (en) | 2004-04-05 | 2004-05-12 | Novartis Ag | Organic compounds |
FR2876583B1 (en) | 2004-10-15 | 2007-04-13 | Centre Nat Rech Scient Cnrse | USE OF PURINE DERIVATIVES FOR THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF MUCOVISCIDOSIS AND DISEASES ASSOCIATED WITH A DEFECT OF ADDRESSING PROTEINS IN CELLS |
GB0500785D0 (en) | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
CA2601527A1 (en) | 2005-03-14 | 2006-09-21 | Neurosearch A/S | Potassium channel modulating agents and their medical use |
GB0505219D0 (en) | 2005-03-14 | 2005-04-20 | Novartis Ag | Organic compounds |
US20090036475A1 (en) | 2005-03-22 | 2009-02-05 | Neurosearch A/S | Pyrazolyl-Pyrimidines as Potassium Channel Modulating Agents and Their Medical Use |
CA2609117A1 (en) | 2005-05-19 | 2006-11-23 | Cv Therapeutics, Inc. | A1 adenosine receptor agonists |
AU2006298867A1 (en) | 2005-09-19 | 2007-04-12 | F. Hoffmann-La Roche Ag | Isoxazolo derivatives as GABA A alpha5 inverse agonists |
AU2006301376A1 (en) | 2005-10-11 | 2007-04-19 | F. Hoffmann-La Roche Ag | Isoxazole derivatives |
BRPI0618383A2 (en) | 2005-11-09 | 2011-08-30 | Hoffmann La Roche | 3-aryl-isoxazole-4-carbonyl-benzofuran derivatives |
JP2009519995A (en) | 2005-12-20 | 2009-05-21 | ノイロサーチ アクティーゼルスカブ | 2-Pyridin-2-yl-quinazoline derivatives as potassium channel modulators for the treatment of respiratory diseases |
RU2426731C2 (en) | 2005-12-23 | 2011-08-20 | Ф. Хоффманн-Ля Рош Аг | Aryl-isoxazol-4-yl-oxadiazole derivatives |
JP4864982B2 (en) | 2005-12-27 | 2012-02-01 | エフ.ホフマン−ラ ロシュ アーゲー | Aryl-isoxazol-4-yl-imidazo [1,5-a] pyridine derivatives |
DK1968973T3 (en) | 2005-12-27 | 2011-10-31 | Hoffmann La Roche | Aryl-isoxazol-4-yl-imidazole |
TW200812982A (en) * | 2006-05-24 | 2008-03-16 | Lilly Co Eli | Compounds and methods for modulating FXR |
ES2328185T3 (en) | 2006-05-31 | 2009-11-10 | F. Hoffmann-La Roche Ag | DERIVATIVES OF ARIL-4-ETINIL-ISOXAZOL. |
EP1894928A1 (en) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Heterocyclic fxr binding compounds |
EP1894924A1 (en) | 2006-08-29 | 2008-03-05 | Phenex Pharmaceuticals AG | Heterocyclic FXR binding compounds |
US20110144140A1 (en) | 2006-09-07 | 2011-06-16 | Eriksen Birgitte L | Pyridinyl-pyrimidine derivatives useful as potassium channel modulating agents |
US8222262B2 (en) | 2006-10-03 | 2012-07-17 | Neurosearch A/S | Indazolyl derivatives useful as potassium channel modulating agents |
JP2010516774A (en) | 2007-01-26 | 2010-05-20 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Purine compounds and compositions as kinase inhibitors for treating Plasmodium related diseases |
US20100035934A1 (en) | 2007-02-02 | 2010-02-11 | Neurosearch A/S | Pyridinyl-pyrazole derivatives and their use as potassium channel modulators |
NZ579248A (en) | 2007-03-28 | 2011-08-26 | Neurosearch As | Purinyl derivatives and their use as potassium channel modulators |
EP2132208A1 (en) | 2007-03-28 | 2009-12-16 | NeuroSearch AS | Purinyl derivatives and their use as potassium channel modulators |
ES2369805T3 (en) | 2007-06-22 | 2011-12-07 | F. Hoffmann-La Roche Ag | DERIVATIVES OF ISOXAZOL-IMIDAZOL. |
WO2009050199A1 (en) | 2007-10-17 | 2009-04-23 | Novartis Ag | Purine derivatives as adenosine al receptor ligands |
CN101883769B (en) | 2007-12-04 | 2012-08-08 | 弗·哈夫曼-拉罗切有限公司 | Isoxazolo-pyrazine derivatives |
US7943619B2 (en) * | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
DK2767536T3 (en) | 2007-12-04 | 2015-10-19 | Hoffmann La Roche | Isoxazolo-pyridine derivatives |
EP2128158A1 (en) | 2008-05-26 | 2009-12-02 | Phenex Pharmaceuticals AG | Heterocyclic cyclopropyl-substituted FXR binding compounds |
GEP20135957B (en) * | 2008-06-19 | 2013-11-11 | Takeda Pharmaceuticals Co | Heterocyclic compound and usage thereof |
EP2344501A1 (en) | 2008-09-26 | 2011-07-20 | NeuroSearch A/S | Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators |
US8268838B2 (en) | 2008-09-26 | 2012-09-18 | Neurosearch A/S | Substituted purinyl-pyrazole derivatives and their use as potassium channel modulators |
PE20100362A1 (en) | 2008-10-30 | 2010-05-27 | Irm Llc | PURINE DERIVATIVES THAT EXPAND HEMATOPOYETIC STEM CELLS |
US8389550B2 (en) | 2009-02-25 | 2013-03-05 | Hoffmann-La Roche Inc. | Isoxazoles / O-pyridines with ethyl and ethenyl linker |
US8222246B2 (en) | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
US20100280019A1 (en) | 2009-04-30 | 2010-11-04 | Roland Jakob-Roetne | Isoxazoles |
KR101384829B1 (en) | 2009-05-05 | 2014-04-15 | 에프. 호프만-라 로슈 아게 | Isoxazole-pyrazole derivatives |
CA2760166C (en) | 2009-05-05 | 2017-07-18 | F. Hoffmann-La Roche Ag | Isoxazole-pyridine derivatives |
MX2011011490A (en) | 2009-05-05 | 2011-11-18 | Hoffmann La Roche | Isoxazole-thiazole derivatives as gaba a receptor inverse agonists for use in the treatment of cognitive disorders. |
EP2427458B1 (en) | 2009-05-05 | 2014-05-07 | F.Hoffmann-La Roche Ag | Isoxazole-pyridazine derivatives |
WO2010127978A1 (en) | 2009-05-07 | 2010-11-11 | F. Hoffmann-La Roche Ag | Isoxazole-pyridine derivatives as gaba modulators |
EP2289883A1 (en) | 2009-08-19 | 2011-03-02 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
CA2815741A1 (en) * | 2010-11-09 | 2012-05-18 | F. Hoffmann-La Roche Ag | Triazole derivatives as ligands for gaba receptors |
US8742097B2 (en) * | 2010-11-09 | 2014-06-03 | Hoffmann-La Roche Inc. | Triazole compounds I |
US8466181B2 (en) | 2010-12-10 | 2013-06-18 | Hoffmann-La Roche Inc. | 1,2,3-triazole-imidazole compounds |
-
2013
- 2013-06-25 RU RU2014149123A patent/RU2014149123A/en not_active Application Discontinuation
- 2013-06-25 EP EP13730899.5A patent/EP2885290B1/en not_active Not-in-force
- 2013-06-25 JP JP2015519035A patent/JP6223443B2/en not_active Expired - Fee Related
- 2013-06-25 CA CA2876780A patent/CA2876780A1/en not_active Abandoned
- 2013-06-25 WO PCT/EP2013/063194 patent/WO2014001282A1/en active Application Filing
- 2013-06-25 IN IN11027DEN2014 patent/IN2014DN11027A/en unknown
- 2013-06-25 BR BR112014032501A patent/BR112014032501A2/en not_active IP Right Cessation
- 2013-06-25 KR KR20157001895A patent/KR20150033679A/en not_active Application Discontinuation
- 2013-06-25 US US14/411,326 patent/US9475797B2/en active Active
- 2013-06-25 AU AU2013283488A patent/AU2013283488A1/en not_active Abandoned
- 2013-06-25 MX MX2014014872A patent/MX2014014872A/en unknown
- 2013-06-25 CN CN201380034072.1A patent/CN104411703A/en active Pending
-
2014
- 2014-11-30 IL IL235991A patent/IL235991A/en not_active IP Right Cessation
-
2016
- 2016-10-11 US US15/290,480 patent/US9884848B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20170114045A1 (en) | 2017-04-27 |
CA2876780A1 (en) | 2014-01-03 |
MX2014014872A (en) | 2015-08-06 |
IL235991A (en) | 2017-07-31 |
US9884848B2 (en) | 2018-02-06 |
BR112014032501A2 (en) | 2017-06-27 |
IL235991A0 (en) | 2015-02-01 |
US9475797B2 (en) | 2016-10-25 |
EP2885290B1 (en) | 2017-10-18 |
CN104411703A (en) | 2015-03-11 |
US20160115155A1 (en) | 2016-04-28 |
KR20150033679A (en) | 2015-04-01 |
RU2014149123A (en) | 2016-08-20 |
AU2013283488A1 (en) | 2015-01-15 |
JP2015521643A (en) | 2015-07-30 |
EP2885290A1 (en) | 2015-06-24 |
JP6223443B2 (en) | 2017-11-01 |
WO2014001282A1 (en) | 2014-01-03 |
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