IN2015DN00372A - - Google Patents

Info

Publication number
IN2015DN00372A
IN2015DN00372A IN372DEN2015A IN2015DN00372A IN 2015DN00372 A IN2015DN00372 A IN 2015DN00372A IN 372DEN2015 A IN372DEN2015 A IN 372DEN2015A IN 2015DN00372 A IN2015DN00372 A IN 2015DN00372A
Authority
IN
India
Prior art keywords
met
synthesis
treating
formula
relates
Prior art date
Application number
Inventor
Shaojing Hu
Fei Wang
Zhiguo Xu
Yanping Wang
Yinxiang Wang
Original Assignee
Zhejiang Beta Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Beta Pharmaceuticals Co Ltd filed Critical Zhejiang Beta Pharmaceuticals Co Ltd
Publication of IN2015DN00372A publication Critical patent/IN2015DN00372A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

This invention relates to novel fused quinazoline derivatives of Formula I as c Met inhibitors their synthesis and uses for treating c Met mediated disorders.
IN372DEN2015 2012-06-29 2013-07-01 IN2015DN00372A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2012077924 2012-06-29
PCT/CN2013/078592 WO2014000713A1 (en) 2012-06-29 2013-07-01 NOVEL FUSED PYRIDINE DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS

Publications (1)

Publication Number Publication Date
IN2015DN00372A true IN2015DN00372A (en) 2015-06-12

Family

ID=49782283

Family Applications (1)

Application Number Title Priority Date Filing Date
IN372DEN2015 IN2015DN00372A (en) 2012-06-29 2013-07-01

Country Status (14)

Country Link
US (1) US9617257B2 (en)
EP (1) EP2867223B1 (en)
JP (1) JP6059342B2 (en)
KR (3) KR101726522B1 (en)
AU (1) AU2013283993B2 (en)
BR (1) BR112014032745B1 (en)
CA (1) CA2878049C (en)
ES (1) ES2698511T3 (en)
IN (1) IN2015DN00372A (en)
RU (1) RU2619130C2 (en)
SG (1) SG11201408750VA (en)
TW (1) TWI520962B (en)
WO (1) WO2014000713A1 (en)
ZA (1) ZA201500344B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106279147A (en) * 2015-05-21 2017-01-04 中国科学院上海药物研究所 A kind of pyrido nitrogen heterocyclic and its production and use
ES2769124T3 (en) * 2015-07-20 2020-06-24 Betta Pharmaceuticals Co Ltd Crystalline form of maleate of condensed pyridine derivatives and uses thereof
CN106924260B (en) * 2015-12-31 2018-05-25 北京浦润奥生物科技有限责任公司 Application of compound in preparation of medicine for treating brain glioma
SG11201806302RA (en) 2016-02-05 2018-08-30 Denali Therapeutics Inc Inhibitors of receptor-interacting protein kinase 1
PL3552017T3 (en) 2016-12-09 2022-08-08 Denali Therapeutics Inc. Compounds useful as ripk1 inhibitors
KR20200011965A (en) * 2017-05-26 2020-02-04 아이크노스 사이언스 에스. 아. Novel Inhibitors of MAP4K1
JP7131837B2 (en) * 2017-06-19 2022-09-06 アビスコ セラピューティクス カンパニー リミテッド AZAaryl DERIVATIVE HAVING CSF-1R INHIBITING ACTIVITY, PRODUCTION AND APPLICATION THEREOF
CN109988108B (en) * 2017-12-29 2022-04-29 江苏豪森药业集团有限公司 Preparation method of cabozantinib
EA202191541A1 (en) * 2018-12-14 2022-01-21 Бета Фарма, Инк. ORGANOPHOSPHATE SUBSTITUTED COMPOUNDS AS c-MET INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS
MX2021009863A (en) 2019-03-21 2021-11-12 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer.
KR20220098759A (en) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) A method of treating cancer that has acquired resistance to a kinase inhibitor
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
TWI812301B (en) * 2021-06-24 2023-08-11 南韓商Ｌｇ化學股份有限公司 Novel urea derivative compound as ron inhibitor
AU2023206890A1 (en) 2022-01-12 2024-08-22 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide
EP4289427A1 (en) * 2022-06-10 2023-12-13 Anagenesis Biotechnologies Dihydro[1,8]naphthyridin-7-one and pyrido[3,2-b][1,4]oxazin-3-one for use in treating cancer, and metastases in particular.

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
US20070213374A1 (en) 2003-07-07 2007-09-13 Merck Patent Gmbh Malonamide Derivatives
DE10357510A1 (en) 2003-12-09 2005-07-07 Bayer Healthcare Ag Heteroaryl-substituted benzenes
US20050288290A1 (en) * 2004-06-28 2005-12-29 Borzilleri Robert M Fused heterocyclic kinase inhibitors
EP1773826A4 (en) * 2004-07-02 2009-06-03 Exelixis Inc C-met modulators and method of use
MX2007001216A (en) * 2004-07-30 2007-03-23 Methylgene Inc Inhibitors of vegf receptor and hgf receptor signaling.
JP2008521900A (en) 2004-11-30 2008-06-26 アムジエン・インコーポレーテツド Quinolines and quinazoline analogues and their use as medicaments for the treatment of cancer
JO2787B1 (en) * 2005-04-27 2014-03-15 امجين إنك, Substituted Amid derivatives & methods of use
NZ563774A (en) 2005-05-20 2010-04-30 Methylgene Inc Inhibitors of VEGF receptor and HGF receptor signaling
JP2010507618A (en) * 2006-10-27 2010-03-11 グラクソ グループ リミテッド 7-azaindole derivatives as c-Met kinase inhibitors
US7960567B2 (en) 2007-05-02 2011-06-14 Amgen Inc. Compounds and methods useful for treating asthma and allergic inflammation
MX2011004018A (en) * 2008-10-14 2011-06-24 Ning Xi Compounds and methods of use.
KR100961410B1 (en) * 2008-10-14 2010-06-09 (주)네오팜 As protein kinase inhibitors, heterocyclic compounds
CN102086211B (en) * 2009-12-08 2013-09-11 广东东阳光药业有限公司 Aromatic heterocyclic compounds serving as protein kinase inhibitor
ES2598530T3 (en) * 2010-07-14 2017-01-27 Betta Pharmaceuticals Co., Ltd. New condensed heterocyclic derivatives useful as c-Met tyrosine kinase inhibitors

Also Published As

Publication number Publication date
BR112014032745B1 (en) 2022-01-04
KR101726522B1 (en) 2017-04-12
SG11201408750VA (en) 2015-01-29
EP2867223B1 (en) 2018-09-05
JP6059342B2 (en) 2017-01-11
ES2698511T3 (en) 2019-02-05
CA2878049A1 (en) 2014-01-03
WO2014000713A1 (en) 2014-01-03
KR101770545B1 (en) 2017-08-22
AU2013283993B2 (en) 2016-07-07
AU2013283993A1 (en) 2015-02-05
JP2015521634A (en) 2015-07-30
KR101726555B1 (en) 2017-04-12
KR20170017015A (en) 2017-02-14
KR20150031320A (en) 2015-03-23
EP2867223A1 (en) 2015-05-06
HK1207642A1 (en) 2016-02-05
TW201418254A (en) 2014-05-16
TWI520962B (en) 2016-02-11
EP2867223A4 (en) 2016-01-06
US9617257B2 (en) 2017-04-11
CA2878049C (en) 2016-12-13
RU2619130C2 (en) 2017-05-12
KR20170017014A (en) 2017-02-14
RU2015102057A (en) 2016-08-20
BR112014032745A2 (en) 2017-06-27
ZA201500344B (en) 2016-08-31
US20150315210A1 (en) 2015-11-05

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