KR20140145948A - 안과 치료제 - Google Patents
안과 치료제 Download PDFInfo
- Publication number
- KR20140145948A KR20140145948A KR1020137029016A KR20137029016A KR20140145948A KR 20140145948 A KR20140145948 A KR 20140145948A KR 1020137029016 A KR1020137029016 A KR 1020137029016A KR 20137029016 A KR20137029016 A KR 20137029016A KR 20140145948 A KR20140145948 A KR 20140145948A
- Authority
- KR
- South Korea
- Prior art keywords
- eye
- composition
- tramadol
- treatment
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Landscapes
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| GB1105731.2 | 2011-04-05 | ||
| PCT/GB2012/000330 WO2012136969A2 (en) | 2011-04-05 | 2012-04-05 | Ophthalmic treatments |
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| GB201217522D0 (en) * | 2012-10-01 | 2012-11-14 | Sharma Anant | ophthalmic therapy |
| CA2909117A1 (en) * | 2013-04-09 | 2014-10-16 | Cresset Biomolecular Discovery Ltd | The treatment of inflammatory disorders |
| ES2540151B1 (es) * | 2013-10-11 | 2016-02-29 | Farmalider S.A. | Composición farmacéutica de ibuprofeno y tramadol para uso oftálmico |
| RU2549472C1 (ru) * | 2013-12-26 | 2015-04-27 | Илья Александрович Марков | Фармацевтическая композиция в форме капель для профилактики и лечения аллергических заболеваний глаз |
| WO2015106068A1 (en) * | 2014-01-10 | 2015-07-16 | Manistee Partners Llc | Treatment of migraines |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| WO2016172712A2 (en) | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
| WO2016022066A1 (en) | 2014-08-04 | 2016-02-11 | Jerry Tan Eye Surgery Pte Ltd | Pharmaceutical compositions for demodex related blepharitis and eyelid crusting |
| ES2936394T3 (es) * | 2015-02-24 | 2023-03-16 | Univ Illinois | Métodos y composiciones para tratar la enfermedad del ojo seco y otros trastornos oculares |
| US9877964B2 (en) | 2015-02-24 | 2018-01-30 | Ocugen, Inc. | Methods and compositions for treating dry eye disease and other eye disorders |
| WO2016196367A1 (en) | 2015-05-29 | 2016-12-08 | Sydnexis, Inc. | D2o stabilized pharmaceutical formulations |
| ES2604816B1 (es) * | 2015-09-09 | 2018-01-29 | Farmalider, S.A. | Composición farmacéutica de tramadol para uso oftálmico |
| CN113577097A (zh) * | 2015-09-24 | 2021-11-02 | 基质生物研究所 | 高弹性透明质酸组合物及其使用方法 |
| US20180344676A1 (en) * | 2015-09-30 | 2018-12-06 | George Edward Hoag | Topical analgesic pain relief formulations, manufacture and methods of use thereof |
| CN105232449B (zh) * | 2015-10-30 | 2019-04-09 | 上海昊海生物科技股份有限公司 | 盐酸莫西沙星透明质酸钠缓释纳米凝胶及其制备方法 |
| CA3285799A1 (en) * | 2016-10-12 | 2025-11-29 | Ps Therapy, Inc. | Artificial tear, contact lens and drug vehicle compositions and methods of use thereof |
| JP2020523406A (ja) | 2017-05-19 | 2020-08-06 | オクジェン アイエヌシー． | 眼科用組成物および使用方法 |
| SG11201911750RA (en) * | 2017-06-08 | 2020-01-30 | Eye Therapies Llc | Low-dose brimonidine combinations and uses thereof |
| KR20200111177A (ko) * | 2017-12-15 | 2020-09-28 | 타르서스 파마수티칼스, 아이엔씨. | 안검염을 치료하기 위한 이속사졸린 구충제 제제 및 방법 |
| WO2019122982A1 (en) | 2017-12-21 | 2019-06-27 | Grünenthal GmbH | Pharmaceutical combination in a bilayer tablet form comprising ketorolac tromethamine and tramadol hydrochloride, and its use in pain treatment |
| CN111886001A (zh) * | 2018-03-13 | 2020-11-03 | 参天制药株式会社 | 滴眼型洗眼药用组合物 |
| US12502377B2 (en) | 2019-04-04 | 2025-12-23 | Tarsus Pharmaceuticals, Inc. | Method of eradicating ticks that attach to humans using lotilaner formulations |
| FR3096890B1 (fr) * | 2019-06-07 | 2021-05-14 | H4 Orphan Pharma | Utilisation d’une molécule opioïde pour traiter l’œil sec et l’œil allergique. |
| US20220265695A1 (en) | 2019-07-26 | 2022-08-25 | Proqr Therapeutics Ii B.V. | Opthalmic compositions comprising viscosifying polymers and nucleic acids |
| US11504269B2 (en) | 2019-11-19 | 2022-11-22 | Jennifer L. Fabian | Therapeutic bra |
| WO2021163304A1 (en) * | 2020-02-11 | 2021-08-19 | Tufts Medical Center, Inc. | Activation of neuropeptide receptors on plasmacytoid dendritic cells to treat or prevent ocular diseases associated with neovascularization and inflammation |
| CN112007028A (zh) * | 2020-09-03 | 2020-12-01 | 北京博纳致恒科技有限责任公司 | 一种复合睫状肌松弛剂的人工泪液及用途 |
| JP2024509372A (ja) * | 2021-02-26 | 2024-03-01 | ヴァイルマ インコーポレイテッド | ガバペンチノイドの局所投与のための方法及び製剤 |
| WO2023285878A1 (en) * | 2021-07-13 | 2023-01-19 | Aviation-Ophthalmology | Methods for detecting, treating, and preventing gpr68-mediated ocular diseases, disorders, and conditions |
| TW202408467A (zh) * | 2022-07-06 | 2024-03-01 | 日商樂敦製藥股份有限公司 | 眼科組成物 |
| JPWO2024010044A1 (enExample) * | 2022-07-06 | 2024-01-11 | ||
| EP4534081A1 (en) * | 2022-07-06 | 2025-04-09 | Rohto Pharmaceutical Co., Ltd. | Ophthalmic composition |
| WO2024010045A1 (ja) * | 2022-07-06 | 2024-01-11 | 学校法人金沢医科大学 | 疼痛抑制剤 |
| WO2025146828A1 (ja) * | 2024-01-05 | 2025-07-10 | ロート製薬株式会社 | 眼科組成物 |
| WO2025159099A1 (ja) * | 2024-01-24 | 2025-07-31 | 国立大学法人北海道大学 | 医薬組成物、眼瞼けいれん処置薬、知覚過敏またはジストニア処置薬、および症状モデルマウス |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6384043B1 (en) | 1993-02-01 | 2002-05-07 | Gholam A. Peyman | Methods of alleviating pain sensations of the denuded eye with opioid analgesics |
| US6017963A (en) * | 1995-11-14 | 2000-01-25 | Euro-Celtique, S.A. | Formulation for intranasal administration |
| JP2001506652A (ja) * | 1996-12-16 | 2001-05-22 | アルコン ラボラトリーズ，インコーポレイテッド | 眼の痛みを治療するためのκオピオイド・アゴニストの局所使用 |
| US6174878B1 (en) * | 1999-08-31 | 2001-01-16 | Alcon Laboratories, Inc. | Topical use of kappa opioid agonists to treat otic pain |
| JP2004143157A (ja) * | 2002-10-01 | 2004-05-20 | Taisho Pharmaceut Co Ltd | 点眼剤 |
| US20060172972A1 (en) * | 2002-12-20 | 2006-08-03 | Chakshu Research Inc | Formulation and method for administration of ophthalmologically active agents |
| PL1768650T3 (pl) | 2004-06-04 | 2009-01-30 | Camurus Ab | Ciekłe formulacje depot |
| EP1611877A1 (en) * | 2004-06-28 | 2006-01-04 | Universidade de Coimbra | Method for preparing sustained-release therapeutic ophthalmic articles using compressed fluids for impregnation of drugs |
| WO2007057508A2 (en) | 2005-11-18 | 2007-05-24 | Orion Corporation | Treatment of pain with a combination of an alpha2 -adrenoceptor antagonist such as atipemezole or fipamezoiie and an opioid receptor agonist, such as tramadol |
| JP2009524692A (ja) * | 2006-01-25 | 2009-07-02 | アーシエックス， インコーポレイテッド | ドライアイのための処方物および方法 |
| CN101754748A (zh) * | 2007-05-24 | 2010-06-23 | 阿西克斯医疗公司 | 治疗干眼症的制剂和方法 |
| EP2311446A1 (en) * | 2009-10-16 | 2011-04-20 | Laboratorios Del. Dr. Esteve, S.A. | Compositions comprising Tramadol and Celecoxib in the treatment of pain |
| MX346312B (es) * | 2011-04-05 | 2017-03-15 | Optosolve Res & Dev Ltd | Tratamientos oftalmicos. |
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| US9913813B2 (en) | 2018-03-13 |
| WO2012136969A2 (en) | 2012-10-11 |
| BR112013025493A2 (pt) | 2017-03-01 |
| US20140088199A1 (en) | 2014-03-27 |
| CA2869280A1 (en) | 2012-10-11 |
| ES2836808T3 (es) | 2021-06-28 |
| JP6419876B2 (ja) | 2018-11-07 |
| EP3799866A1 (en) | 2021-04-07 |
| WO2012136969A3 (en) | 2013-01-03 |
| MA35070B1 (fr) | 2014-04-03 |
| HK1254720A1 (zh) | 2019-07-26 |
| MX346312B (es) | 2017-03-15 |
| MX2013011314A (es) | 2014-03-27 |
| KR102165246B1 (ko) | 2020-10-13 |
| JP6148664B2 (ja) | 2017-06-14 |
| EP2694048B1 (en) | 2020-10-07 |
| JP2014513073A (ja) | 2014-05-29 |
| CA2869280C (en) | 2020-03-10 |
| CN107982211A (zh) | 2018-05-04 |
| EP2694048A2 (en) | 2014-02-12 |
| CN103687594A (zh) | 2014-03-26 |
| KR20190004815A (ko) | 2019-01-14 |
| US20160199320A1 (en) | 2016-07-14 |
| JP2017141243A (ja) | 2017-08-17 |
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