KR20140098074A - 7-((3s,4s)-3-[(사이클로프로필아미노)메틸]-4-플루오로피롤리딘-1-일)-6-플루오로-1-(2-플루오로에틸)-8-메톡시-4-옥소-1,4-다이하이드로퀴놀린-3-카복실산 결정 - Google Patents

7-((3s,4s)-3-[(사이클로프로필아미노)메틸]-4-플루오로피롤리딘-1-일)-6-플루오로-1-(2-플루오로에틸)-8-메톡시-4-옥소-1,4-다이하이드로퀴놀린-3-카복실산 결정 Download PDF

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Publication number
KR20140098074A
KR20140098074A KR1020147012681A KR20147012681A KR20140098074A KR 20140098074 A KR20140098074 A KR 20140098074A KR 1020147012681 A KR1020147012681 A KR 1020147012681A KR 20147012681 A KR20147012681 A KR 20147012681A KR 20140098074 A KR20140098074 A KR 20140098074A
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KR
South Korea
Prior art keywords
crystals
methoxy
hydrochloride salt
dihydroquinoline
oxo
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Ceased
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KR1020147012681A
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English (en)
Korean (ko)
Inventor
이치로 아라야
아키노리 고토
와타루 미나가와
케이코 후나다
무네키 나가오
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교린 세이야꾸 가부시키 가이샤
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Application filed by 교린 세이야꾸 가부시키 가이샤 filed Critical 교린 세이야꾸 가부시키 가이샤
Publication of KR20140098074A publication Critical patent/KR20140098074A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020147012681A 2011-11-10 2012-11-09 7-((3s,4s)-3-[(사이클로프로필아미노)메틸]-4-플루오로피롤리딘-1-일)-6-플루오로-1-(2-플루오로에틸)-8-메톡시-4-옥소-1,4-다이하이드로퀴놀린-3-카복실산 결정 Ceased KR20140098074A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2011246209 2011-11-10
JPJP-P-2011-246209 2011-11-10
JP2012071739 2012-03-27
JPJP-P-2012-071739 2012-03-27
PCT/JP2012/007195 WO2013069297A1 (ja) 2011-11-10 2012-11-09 ７－｛（３s、４s）－３－［（シクロプロピルアミノ)メチル］－４－フルオロピロリジン－1－イル｝－６－フルオロ－１－（２－フルオロエチル）－８－メトキシ－４－オキソ－１、４－ジヒドロキノリン－３－カルボン酸の結晶

Related Child Applications (1)

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KR1020197015481A Division KR102162208B1 (ko) 2011-11-10 2012-11-09 7-((3s,4s)-3-[(사이클로프로필아미노)메틸]-4-플루오로피롤리딘-1-일)-6-플루오로-1-(2-플루오로에틸)-8-메톡시-4-옥소-1,4-다이하이드로퀴놀린-3-카복실산 결정

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KR20140098074A true KR20140098074A (ko) 2014-08-07

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KR1020147012681A Ceased KR20140098074A (ko) 2011-11-10 2012-11-09 7-((3s,4s)-3-[(사이클로프로필아미노)메틸]-4-플루오로피롤리딘-1-일)-6-플루오로-1-(2-플루오로에틸)-8-메톡시-4-옥소-1,4-다이하이드로퀴놀린-3-카복실산 결정
KR1020197015481A Active KR102162208B1 (ko) 2011-11-10 2012-11-09 7-((3s,4s)-3-[(사이클로프로필아미노)메틸]-4-플루오로피롤리딘-1-일)-6-플루오로-1-(2-플루오로에틸)-8-메톡시-4-옥소-1,4-다이하이드로퀴놀린-3-카복실산 결정

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KR1020197015481A Active KR102162208B1 (ko) 2011-11-10 2012-11-09 7-((3s,4s)-3-[(사이클로프로필아미노)메틸]-4-플루오로피롤리딘-1-일)-6-플루오로-1-(2-플루오로에틸)-8-메톡시-4-옥소-1,4-다이하이드로퀴놀린-3-카복실산 결정

Country Status (17)

Country Link
US (3) US9090587B2 (https=)
EP (2) EP3112359B1 (https=)
JP (4) JP5871948B2 (https=)
KR (2) KR20140098074A (https=)
CN (2) CN103930414B (https=)
AU (1) AU2016273899B2 (https=)
BR (1) BR112014010765B1 (https=)
CA (1) CA2855022C (https=)
ES (2) ES2747303T3 (https=)
IN (1) IN2014DN03277A (https=)
MX (1) MX375073B (https=)
NZ (1) NZ623808A (https=)
RU (2) RU2017109814A (https=)
SA (1) SA112330992B1 (https=)
SG (2) SG10201608167UA (https=)
TW (1) TWI547492B (https=)
WO (1) WO2013069297A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170123695A (ko) * 2015-03-13 2017-11-08 교린 세이야꾸 가부시키 가이샤 호흡기 감염증 치료제

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* Cited by examiner, † Cited by third party
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US12594418B2 (en) 2011-03-10 2026-04-07 Electrocore, Inc. Devices and methods for nerve stimulation
SA112330992B1 (ar) * 2011-11-10 2015-09-13 كيورين فارماسوتيكال كو.، ليمتد صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي
WO2014174847A1 (ja) * 2013-04-25 2014-10-30 杏林製薬株式会社 固形医薬組成物
JP6349306B2 (ja) * 2013-04-25 2018-06-27 杏林製薬株式会社 錠剤
US9603804B2 (en) 2013-04-25 2017-03-28 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
GB201402071D0 (en) 2014-02-07 2014-03-26 Galapagos Nv Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
US10154993B2 (en) 2014-10-23 2018-12-18 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
EP3210608A4 (en) * 2014-10-23 2018-06-20 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
WO2016195021A1 (ja) * 2015-06-02 2016-12-08 杏林製薬株式会社 水性液剤
EP3305294A4 (en) * 2015-06-02 2019-02-20 Kyorin Pharmaceutical Co., Ltd. AQUEOUS MEDICINE
JP6675396B2 (ja) * 2015-06-02 2020-04-01 杏林製薬株式会社 水性液剤
BR112019025960A2 (pt) 2017-06-16 2020-11-03 Kyorin Pharmaceutical Co., Ltd. agente terapêutico para pneumonia aspirativa, supuração pulmonar ou abcesso pulmonar
TW202415375A (zh) 2017-06-16 2024-04-16 日商杏林製藥股份有限公司 吸入性肺炎、肺化膿症或肺膿瘍之治療劑
GB201808575D0 (en) 2018-05-24 2018-07-11 Galapagos Nv Methods for the treatment of psoriatic arthrits

Family Cites Families (7)

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ZA944369B (en) * 1993-08-27 1995-02-13 Hokuriku Seuyaku Co Ltd 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative
CN1158846A (zh) * 1995-05-09 1997-09-10 昆山市康壮达兽药厂 盐酸氟哌酸的合成工艺
US20030124028A1 (en) 2001-08-10 2003-07-03 Carlson Eric D. Apparatuses and methods for creating and testing pre-formulations and systems for same
WO2003076428A1 (en) * 2002-03-08 2003-09-18 Daiichi Pharmaceutical Co., Ltd. Quinolonecarboxylic acid derivative
CN100410249C (zh) 2003-09-10 2008-08-13 杏林制药株式会社 7-(4-取代-3-环丙基氨基甲基-1-吡咯烷基)喹诺酮羧酸衍生物
CN101003540A (zh) * 2006-01-18 2007-07-25 广州白云山制药股份有限公司广州白云山制药总厂 一种抗感染化合物和用途
SA112330992B1 (ar) * 2011-11-10 2015-09-13 كيورين فارماسوتيكال كو.، ليمتد صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170123695A (ko) * 2015-03-13 2017-11-08 교린 세이야꾸 가부시키 가이샤 호흡기 감염증 치료제

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US9328089B2 (en) 2016-05-03
RU2615509C2 (ru) 2017-04-05
SG10201608167UA (en) 2016-11-29
EP3112359B1 (en) 2019-08-21
US9090587B2 (en) 2015-07-28
JP6818719B2 (ja) 2021-01-20
CN104945375A (zh) 2015-09-30
AU2016273899B2 (en) 2017-07-27
EP2778159A1 (en) 2014-09-17
JP6349435B2 (ja) 2018-06-27
IN2014DN03277A (https=) 2015-05-22
EP2778159B1 (en) 2017-03-01
NZ623808A (en) 2015-07-31
US20150284361A1 (en) 2015-10-08
BR112014010765A2 (pt) 2017-06-13
MX375073B (es) 2025-03-06
BR112014010765B1 (pt) 2020-07-14
JP2018158949A (ja) 2018-10-11
RU2017109814A3 (https=) 2020-04-08
KR102162208B1 (ko) 2020-10-06
TWI547492B (zh) 2016-09-01
CN103930414A (zh) 2014-07-16
EP2778159A4 (en) 2015-06-03
AU2012337206A1 (en) 2014-05-22
JP5871948B2 (ja) 2016-03-01
RU2017109814A (ru) 2019-01-23
AU2012337206A8 (en) 2016-09-22
ES2747303T3 (es) 2020-03-10
CA2855022C (en) 2019-05-07
TW201332991A (zh) 2013-08-16
AU2012337206B2 (en) 2016-09-15
CA2855022A1 (en) 2013-05-16
JP2017160243A (ja) 2017-09-14
USRE47785E1 (en) 2019-12-31
US20140288310A1 (en) 2014-09-25
CN104945375B (zh) 2017-07-04
WO2013069297A1 (ja) 2013-05-16
SA112330992B1 (ar) 2015-09-13
KR20190065456A (ko) 2019-06-11
JPWO2013069297A1 (ja) 2015-04-02
JP6514069B2 (ja) 2019-05-15
EP3112359A1 (en) 2017-01-04
ES2621664T3 (es) 2017-07-04
JP2016027045A (ja) 2016-02-18
RU2014123567A (ru) 2015-12-20
CN103930414B (zh) 2016-01-20
AU2016273899A1 (en) 2017-01-12
SG11201401817TA (en) 2014-08-28

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