KR20120112437A - 콜리스틴의 정제 방법 및 정제된 콜리스틴 성분 - Google Patents
콜리스틴의 정제 방법 및 정제된 콜리스틴 성분 Download PDFInfo
- Publication number
- KR20120112437A KR20120112437A KR1020127014083A KR20127014083A KR20120112437A KR 20120112437 A KR20120112437 A KR 20120112437A KR 1020127014083 A KR1020127014083 A KR 1020127014083A KR 20127014083 A KR20127014083 A KR 20127014083A KR 20120112437 A KR20120112437 A KR 20120112437A
- Authority
- KR
- South Korea
- Prior art keywords
- colistin
- column
- polymyxin
- ethanol
- hplc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- RSIJVJUOQBWMIM-UHFFFAOYSA-L sodium sulfate decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[O-]S([O-])(=O)=O RSIJVJUOQBWMIM-UHFFFAOYSA-L 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 229960002898 threonine Drugs 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
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|---|---|---|---|
| US25634409P | 2009-10-30 | 2009-10-30 | |
| US61/256,344 | 2009-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20120112437A true KR20120112437A (ko) | 2012-10-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| KR1020127014083A Abandoned KR20120112437A (ko) | 2009-10-30 | 2010-09-29 | 콜리스틴의 정제 방법 및 정제된 콜리스틴 성분 |
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| KR (1) | KR20120112437A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102596987B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010311759B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2777112A1 (cg-RX-API-DMAC7.html) |
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| HR (1) | HRP20150283T1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL219348A (cg-RX-API-DMAC7.html) |
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| SI (1) | SI2470555T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011051070A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TW201522364A (zh) * | 2013-06-07 | 2015-06-16 | Xellia Pharmaceuticals Aps | 黏菌素甲磺酸鈉（ｃｍｓ）之定性方法 |
| CN103993059B (zh) * | 2014-05-28 | 2016-08-17 | 河北圣雪大成制药有限责任公司 | 优化多粘芽孢杆菌发酵液中e1和e2组分比例的方法 |
| US10711040B2 (en) | 2014-07-09 | 2020-07-14 | Xellia Pharmaceuticals Aps | Low substituted polymyxins and compositions thereof |
| DK3200762T3 (da) | 2014-10-03 | 2019-05-06 | Xellia Pharmaceuticals Aps | Inhalationsanordning |
| JP6633061B2 (ja) | 2014-10-03 | 2020-01-22 | クセリア ファーマシューティカルズ エーピーエスＸｅｌｌｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ ＡｐＳ | 組成物 |
| WO2016166103A1 (en) | 2015-04-13 | 2016-10-20 | Xellia Pharmaceuticals Aps | Polymyxin derivatives |
| CN108226315B (zh) * | 2016-12-15 | 2022-04-12 | 上海医药工业研究院 | 一种检测多黏菌素e残留量的分析方法 |
| PL239311B1 (pl) * | 2018-02-28 | 2021-11-22 | Tarchomińskie Zakłady Farmaceutyczne Polfa Spółka Akcyjna | Sposób izolowania czystego składnika siarczanu polimyksyny E |
| CN115010788B (zh) * | 2022-05-10 | 2024-06-28 | 倪京满 | N-末端脂肪酸修饰的具有抗生物膜活性的低毒广谱抗菌肽类似物及其应用 |
| CN116161962A (zh) * | 2023-02-06 | 2023-05-26 | 中国科学院上海硅酸盐研究所 | 一种具有各向异性电学性能的碳化硅压敏陶瓷及其制备方法 |
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| US20907A (en) | 1858-07-13 | Refrigerator | ||
| GR6498B (el) | 1937-05-11 | 1937-05-12 | Ισιδωρος Τρατσης | Συστημα λειτουργιας επι των εξωτερικων παραθυρων δια την προστασιαν εκ της εισοδου των κωνωπων. |
| ATE202481T1 (de) * | 1996-11-15 | 2001-07-15 | Pathogenesis Corp | Reines, biologisch aktives colistin, seine bestandteile und eine colistin-zubereitung zur behandlung von entzündungen der atemwege |
| SE0300612D0 (sv) * | 2003-03-05 | 2003-03-05 | Amersham Biosciences Ab | A method of preparing ligands for hydrophobic interaction chromatography |
| US7413658B2 (en) * | 2003-11-21 | 2008-08-19 | Akzo Nobel N.V. | Separation method |
| JP5030586B2 (ja) * | 2004-05-26 | 2012-09-19 | 味の素株式会社 | アミノ官能性化合物の分析方法及び装置 |
| WO2007071767A1 (en) * | 2005-12-23 | 2007-06-28 | Novo Nordisk Health Care Ag | Purification of vitamin k-dependent polypeptides using preparative reverse phase chromatography (rpc) |
| CN101525377B (zh) | 2008-03-07 | 2013-04-03 | 上海医药工业研究院 | 一种多黏菌素e甲磺酸钠的分离纯化方法 |
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Also Published As
| Publication number | Publication date |
|---|---|
| PL2470555T3 (pl) | 2015-05-29 |
| JP5882219B2 (ja) | 2016-03-09 |
| AU2010311759A1 (en) | 2012-04-19 |
| IL219348A (en) | 2016-11-30 |
| ES2532408T3 (es) | 2015-03-26 |
| CN102596987A (zh) | 2012-07-18 |
| HRP20150283T1 (hr) | 2015-04-10 |
| DK2470555T3 (en) | 2015-04-07 |
| EP2470555B1 (en) | 2014-12-24 |
| CA2777112A1 (en) | 2011-05-05 |
| IL219348A0 (en) | 2012-06-28 |
| IN2012DN02454A (cg-RX-API-DMAC7.html) | 2015-08-21 |
| AU2010311759B2 (en) | 2015-09-24 |
| CN102596987B (zh) | 2014-06-25 |
| PT2470555E (pt) | 2015-03-23 |
| US20120208981A1 (en) | 2012-08-16 |
| SI2470555T1 (sl) | 2015-04-30 |
| JP2013509365A (ja) | 2013-03-14 |
| WO2011051070A1 (en) | 2011-05-05 |
| EP2470555A1 (en) | 2012-07-04 |
| US9005990B2 (en) | 2015-04-14 |
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