CN102596987B - 用于纯化粘菌素的方法和纯化的粘菌素组分 - Google Patents

用于纯化粘菌素的方法和纯化的粘菌素组分 Download PDF

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Publication number
CN102596987B
CN102596987B CN201080049616.8A CN201080049616A CN102596987B CN 102596987 B CN102596987 B CN 102596987B CN 201080049616 A CN201080049616 A CN 201080049616A CN 102596987 B CN102596987 B CN 102596987B
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China
Prior art keywords
colistin
ethanol
column
polymyxin
hplc
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Expired - Fee Related
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CN201080049616.8A
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English (en)
Chinese (zh)
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CN102596987A (zh
Inventor
托本·科克
卡斯滕·奥弗巴莱-彼得森
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Xellia Pharmaceuticals ApS
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Xellia Pharmaceuticals ApS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201080049616.8A 2009-10-30 2010-09-29 用于纯化粘菌素的方法和纯化的粘菌素组分 Expired - Fee Related CN102596987B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25634409P 2009-10-30 2009-10-30
US61/256,344 2009-10-30
PCT/EP2010/064472 WO2011051070A1 (en) 2009-10-30 2010-09-29 Method for purification of colistin and purified colistin components

Publications (2)

Publication Number Publication Date
CN102596987A CN102596987A (zh) 2012-07-18
CN102596987B true CN102596987B (zh) 2014-06-25

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Country Status (16)

Country Link
US (1) US9005990B2 (cg-RX-API-DMAC7.html)
EP (1) EP2470555B1 (cg-RX-API-DMAC7.html)
JP (1) JP5882219B2 (cg-RX-API-DMAC7.html)
KR (1) KR20120112437A (cg-RX-API-DMAC7.html)
CN (1) CN102596987B (cg-RX-API-DMAC7.html)
AU (1) AU2010311759B2 (cg-RX-API-DMAC7.html)
CA (1) CA2777112A1 (cg-RX-API-DMAC7.html)
DK (1) DK2470555T3 (cg-RX-API-DMAC7.html)
ES (1) ES2532408T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20150283T1 (cg-RX-API-DMAC7.html)
IL (1) IL219348A (cg-RX-API-DMAC7.html)
IN (1) IN2012DN02454A (cg-RX-API-DMAC7.html)
PL (1) PL2470555T3 (cg-RX-API-DMAC7.html)
PT (1) PT2470555E (cg-RX-API-DMAC7.html)
SI (1) SI2470555T1 (cg-RX-API-DMAC7.html)
WO (1) WO2011051070A1 (cg-RX-API-DMAC7.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201522364A (zh) * 2013-06-07 2015-06-16 Xellia Pharmaceuticals Aps 黏菌素甲磺酸鈉（ｃｍｓ）之定性方法
CN103993059B (zh) * 2014-05-28 2016-08-17 河北圣雪大成制药有限责任公司 优化多粘芽孢杆菌发酵液中e1和e2组分比例的方法
US10711040B2 (en) 2014-07-09 2020-07-14 Xellia Pharmaceuticals Aps Low substituted polymyxins and compositions thereof
DK3200762T3 (da) 2014-10-03 2019-05-06 Xellia Pharmaceuticals Aps Inhalationsanordning
JP6633061B2 (ja) 2014-10-03 2020-01-22 クセリア ファーマシューティカルズ エーピーエスＸｅｌｌｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ ＡｐＳ 組成物
WO2016166103A1 (en) 2015-04-13 2016-10-20 Xellia Pharmaceuticals Aps Polymyxin derivatives
CN108226315B (zh) * 2016-12-15 2022-04-12 上海医药工业研究院 一种检测多黏菌素e残留量的分析方法
PL239311B1 (pl) * 2018-02-28 2021-11-22 Tarchomińskie Zakłady Farmaceutyczne Polfa Spółka Akcyjna Sposób izolowania czystego składnika siarczanu polimyksyny E
CN115010788B (zh) * 2022-05-10 2024-06-28 倪京满 N-末端脂肪酸修饰的具有抗生物膜活性的低毒广谱抗菌肽类似物及其应用
CN116161962A (zh) * 2023-02-06 2023-05-26 中国科学院上海硅酸盐研究所 一种具有各向异性电学性能的碳化硅压敏陶瓷及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20907A (en) 1858-07-13 Refrigerator
GR6498B (el) 1937-05-11 1937-05-12 Ισιδωρος Τρατσης Συστημα λειτουργιας επι των εξωτερικων παραθυρων δια την προστασιαν εκ της εισοδου των κωνωπων.
ATE202481T1 (de) * 1996-11-15 2001-07-15 Pathogenesis Corp Reines, biologisch aktives colistin, seine bestandteile und eine colistin-zubereitung zur behandlung von entzündungen der atemwege
SE0300612D0 (sv) * 2003-03-05 2003-03-05 Amersham Biosciences Ab A method of preparing ligands for hydrophobic interaction chromatography
US7413658B2 (en) * 2003-11-21 2008-08-19 Akzo Nobel N.V. Separation method
JP5030586B2 (ja) * 2004-05-26 2012-09-19 味の素株式会社 アミノ官能性化合物の分析方法及び装置
WO2007071767A1 (en) * 2005-12-23 2007-06-28 Novo Nordisk Health Care Ag Purification of vitamin k-dependent polypeptides using preparative reverse phase chromatography (rpc)
CN101525377B (zh) 2008-03-07 2013-04-03 上海医药工业研究院 一种多黏菌素e甲磺酸钠的分离纯化方法

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Publication number Publication date
PL2470555T3 (pl) 2015-05-29
JP5882219B2 (ja) 2016-03-09
AU2010311759A1 (en) 2012-04-19
IL219348A (en) 2016-11-30
ES2532408T3 (es) 2015-03-26
CN102596987A (zh) 2012-07-18
HRP20150283T1 (hr) 2015-04-10
DK2470555T3 (en) 2015-04-07
EP2470555B1 (en) 2014-12-24
CA2777112A1 (en) 2011-05-05
IL219348A0 (en) 2012-06-28
IN2012DN02454A (cg-RX-API-DMAC7.html) 2015-08-21
AU2010311759B2 (en) 2015-09-24
PT2470555E (pt) 2015-03-23
US20120208981A1 (en) 2012-08-16
SI2470555T1 (sl) 2015-04-30
JP2013509365A (ja) 2013-03-14
WO2011051070A1 (en) 2011-05-05
KR20120112437A (ko) 2012-10-11
EP2470555A1 (en) 2012-07-04
US9005990B2 (en) 2015-04-14

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