IN2012DN02454A - - Google Patents

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Publication number
IN2012DN02454A
IN2012DN02454A IN2454DEN2012A IN2012DN02454A IN 2012DN02454 A IN2012DN02454 A IN 2012DN02454A IN 2454DEN2012 A IN2454DEN2012 A IN 2454DEN2012A IN 2012DN02454 A IN2012DN02454 A IN 2012DN02454A
Authority
IN
India
Prior art keywords
colistin
ethanol concentration
eluting
purifying
loading
Prior art date
Application number
Inventor
Torben Koch
Carsten Overballe-Petersen
Original Assignee
Xellia Pharmaceuticals Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xellia Pharmaceuticals Aps filed Critical Xellia Pharmaceuticals Aps
Publication of IN2012DN02454A publication Critical patent/IN2012DN02454A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention concerns a method of purifying colistin using reverse phase chromatography, wherein loading a column with colistin base in acetic acid and high ethanol concentration and eluting with low ethanol concentration is performed.
IN2454DEN2012 2009-10-30 2010-09-29 IN2012DN02454A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25634409P 2009-10-30 2009-10-30
PCT/EP2010/064472 WO2011051070A1 (en) 2009-10-30 2010-09-29 Method for purification of colistin and purified colistin components

Publications (1)

Publication Number Publication Date
IN2012DN02454A true IN2012DN02454A (en) 2015-08-21

Family

ID=42983681

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2454DEN2012 IN2012DN02454A (en) 2009-10-30 2010-09-29

Country Status (16)

Country Link
US (1) US9005990B2 (en)
EP (1) EP2470555B1 (en)
JP (1) JP5882219B2 (en)
KR (1) KR20120112437A (en)
CN (1) CN102596987B (en)
AU (1) AU2010311759B2 (en)
CA (1) CA2777112A1 (en)
DK (1) DK2470555T3 (en)
ES (1) ES2532408T3 (en)
HR (1) HRP20150283T1 (en)
IL (1) IL219348A (en)
IN (1) IN2012DN02454A (en)
PL (1) PL2470555T3 (en)
PT (1) PT2470555E (en)
SI (1) SI2470555T1 (en)
WO (1) WO2011051070A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116161962A (en) * 2023-02-06 2023-05-26 中国科学院上海硅酸盐研究所 Silicon carbide pressure-sensitive ceramic with anisotropic electrical property and preparation method thereof

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201522364A (en) * 2013-06-07 2015-06-16 Xellia Pharmaceuticals Aps Characterization of colistimethate sodium (CMS)
CN103993059B (en) * 2014-05-28 2016-08-17 河北圣雪大成制药有限责任公司 Optimize the method for E1 and E2 component ratio in bacillus polymyxa zymotic fluid
JP2017523953A (en) * 2014-07-09 2017-08-24 クセリア ファーマシューティカルズ エーピーエスＸｅｌｌｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ ＡｐＳ Low substituted polymyxin and composition thereof
PL3200762T3 (en) 2014-10-03 2019-08-30 Xellia Pharmaceuticals Aps Inhalation device
CA2961700C (en) 2014-10-03 2023-03-07 Xellia Pharmaceuticals Aps Aqueous solution of colistimethate sodium
WO2016166103A1 (en) 2015-04-13 2016-10-20 Xellia Pharmaceuticals Aps Polymyxin derivatives
CN108226315B (en) * 2016-12-15 2022-04-12 上海医药工业研究院 Analysis method for detecting polymyxin E residual quantity
PL239311B1 (en) * 2018-02-28 2021-11-22 Tarchomińskie Zakłady Farmaceutyczne Polfa Spółka Akcyjna Method for isolating of pure polymixin E sulfate component
CN115010788B (en) * 2022-05-10 2024-06-28 倪京满 N-terminal fatty acid modified low-toxicity broad-spectrum antibacterial peptide analogue with antibacterial film activity and application thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20907A (en) 1858-07-13 Refrigerator
GR6498B (en) 1937-05-11 1937-05-12 Ισιδωρος Τρατσης OPERATION SYSTEM ON THE EXTERIOR WINDOWS FOR PROTECTION FROM THE ENTRANCE OF THE CONS.
EP0920324B1 (en) * 1996-11-15 2001-06-27 Pathogenesis Corporation Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections
SE0300612D0 (en) * 2003-03-05 2003-03-05 Amersham Biosciences Ab A method of preparing ligands for hydrophobic interaction chromatography
US7413658B2 (en) * 2003-11-21 2008-08-19 Akzo Nobel N.V. Separation method
JP5030586B2 (en) * 2004-05-26 2012-09-19 味の素株式会社 Method and apparatus for analyzing amino-functional compounds
WO2007071767A1 (en) * 2005-12-23 2007-06-28 Novo Nordisk Health Care Ag Purification of vitamin k-dependent polypeptides using preparative reverse phase chromatography (rpc)
CN101525377B (en) * 2008-03-07 2013-04-03 上海医药工业研究院 Method for separating and purifying method of polymyxin E methanesulfonic sodium

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116161962A (en) * 2023-02-06 2023-05-26 中国科学院上海硅酸盐研究所 Silicon carbide pressure-sensitive ceramic with anisotropic electrical property and preparation method thereof

Also Published As

Publication number Publication date
CN102596987B (en) 2014-06-25
IL219348A0 (en) 2012-06-28
IL219348A (en) 2016-11-30
EP2470555A1 (en) 2012-07-04
CA2777112A1 (en) 2011-05-05
JP5882219B2 (en) 2016-03-09
SI2470555T1 (en) 2015-04-30
PT2470555E (en) 2015-03-23
JP2013509365A (en) 2013-03-14
PL2470555T3 (en) 2015-05-29
ES2532408T3 (en) 2015-03-26
KR20120112437A (en) 2012-10-11
DK2470555T3 (en) 2015-04-07
EP2470555B1 (en) 2014-12-24
AU2010311759B2 (en) 2015-09-24
HRP20150283T1 (en) 2015-04-10
US9005990B2 (en) 2015-04-14
AU2010311759A1 (en) 2012-04-19
WO2011051070A1 (en) 2011-05-05
CN102596987A (en) 2012-07-18
US20120208981A1 (en) 2012-08-16

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