KR20120024610A - 혈액응고시간 연장제 - Google Patents

혈액응고시간 연장제 Download PDF

Info

Publication number
KR20120024610A
KR20120024610A KR1020117027191A KR20117027191A KR20120024610A KR 20120024610 A KR20120024610 A KR 20120024610A KR 1020117027191 A KR1020117027191 A KR 1020117027191A KR 20117027191 A KR20117027191 A KR 20117027191A KR 20120024610 A KR20120024610 A KR 20120024610A
Authority
KR
South Korea
Prior art keywords
blood coagulation
alkyl group
time
amino group
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020117027191A
Other languages
English (en)
Korean (ko)
Inventor
치츠루 모리카와
레미 나카무라
미츠아키 야마모토
Original Assignee
세키스이 메디칼 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 세키스이 메디칼 가부시키가이샤 filed Critical 세키스이 메디칼 가부시키가이샤
Publication of KR20120024610A publication Critical patent/KR20120024610A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/02—Guanidine; Salts, complexes or addition compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020117027191A 2009-05-20 2010-05-20 혈액응고시간 연장제 Ceased KR20120024610A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JPJP-P-2009-121834 2009-05-20
JP2009121834 2009-05-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020187004669A Division KR101882408B1 (ko) 2009-05-20 2010-05-20 혈액응고시간 연장제

Publications (1)

Publication Number Publication Date
KR20120024610A true KR20120024610A (ko) 2012-03-14

Family

ID=43126036

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020117027191A Ceased KR20120024610A (ko) 2009-05-20 2010-05-20 혈액응고시간 연장제
KR1020187004669A Active KR101882408B1 (ko) 2009-05-20 2010-05-20 혈액응고시간 연장제

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020187004669A Active KR101882408B1 (ko) 2009-05-20 2010-05-20 혈액응고시간 연장제

Country Status (7)

Country Link
US (3) US20120064553A1 (https=)
EP (2) EP2434290B1 (https=)
JP (2) JPWO2010134345A1 (https=)
KR (2) KR20120024610A (https=)
CN (1) CN102428372A (https=)
CA (1) CA2762611C (https=)
WO (1) WO2010134345A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5903215B2 (ja) * 2011-02-28 2016-04-13 シスメックス株式会社 ループスアンチコアグラント検出用試薬キット及びループスアンチコアグラントの存否を判定する方法
IL312865B2 (en) 2013-09-11 2025-06-01 Eagle Biologics Inc Liquid protein formulations containing viscosity-lowering agents
EP3142645A4 (en) 2014-05-15 2017-12-27 Rani Therapeutics, LLC Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
EP3200804A4 (en) 2014-10-01 2018-04-18 Eagle Biologics, Inc. Polysaccharide and nucleic acid formulations containing viscosity-lowering agents
CN105372424A (zh) * 2015-11-12 2016-03-02 武汉景川诊断技术股份有限公司 肝促凝血活酶试验测定试剂盒及其制备方法
US20240218344A1 (en) * 2022-12-23 2024-07-04 Instrumentation Laboratory Company Liquid thrombin reagent
EP4667582A1 (en) * 2024-06-20 2025-12-24 Instrumentation Laboratory Company Factor xa reagent
US20250389737A1 (en) * 2024-06-20 2025-12-25 Instrumentation Laboratory Company FACTOR Xa REAGENT

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3074611B2 (ja) 1991-08-30 2000-08-07 シスメックス株式会社 血液凝固測定方法
JP3180824B2 (ja) 1991-08-30 2001-06-25 シスメックス株式会社 血液凝固試薬
US5358853A (en) 1992-08-03 1994-10-25 Akzo Av Liquid thromboplastin reagent
JPH0815263A (ja) 1994-06-24 1996-01-19 Shimadzu Corp 血液凝固分析装置
JP2994557B2 (ja) * 1994-09-02 1999-12-27 株式会社アズウェル フィブリノゲン測定方法およびその測定試薬
DE19549118C2 (de) * 1995-12-29 2000-07-13 Thomas W Stief Hämostaseaktivierungs-Inhibitor und Verfahren zum Hemmen der Hämostaseaktivierung in Blut oder anderen biologischen Flüssigkeiten
TW499412B (en) * 1996-11-26 2002-08-21 Dimensional Pharm Inc Aminoguanidines and alkoxyguanidines as protease inhibitors
TWI222441B (en) * 1997-11-26 2004-10-21 Dimensional Pharm Inc Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
DE10222234A1 (de) * 2002-05-16 2003-11-27 Roche Diagnostics Gmbh Kontroll- und Kalibrationsmaterial für Blutgerinnungstests
CN1504580A (zh) * 2002-11-28 2004-06-16 希森美康株式会社 凝血酶试剂以及检查试剂套装
JP2004191367A (ja) * 2002-11-28 2004-07-08 Sysmex Corp トロンビン試薬及び検査試薬キット
DE10362199B4 (de) * 2003-06-04 2009-09-10 Stief, Thomas, Dr.med. Nachweisverfahren für Fibrinogen
EP1672369A1 (de) * 2004-12-16 2006-06-21 Roche Diagnostics GmbH Verfahren zur Bestimmung von Blutkoagulationsparametern, insbesondere in Durchflussmesssystemen

Also Published As

Publication number Publication date
US20150185236A1 (en) 2015-07-02
WO2010134345A1 (ja) 2010-11-25
JP5840273B2 (ja) 2016-01-06
EP2434290A4 (en) 2013-01-30
CN102428372A (zh) 2012-04-25
KR101882408B1 (ko) 2018-07-27
EP3018481B1 (en) 2018-02-21
US9733262B2 (en) 2017-08-15
EP2434290B1 (en) 2016-02-10
EP3018481A1 (en) 2016-05-11
KR20180019781A (ko) 2018-02-26
JP2015042652A (ja) 2015-03-05
EP2434290A1 (en) 2012-03-28
JPWO2010134345A1 (ja) 2012-11-08
CA2762611A1 (en) 2010-11-25
US20140127727A1 (en) 2014-05-08
US20120064553A1 (en) 2012-03-15
CA2762611C (en) 2017-03-28

Similar Documents

Publication Publication Date Title
JP5840273B2 (ja) 血液凝固時間延長剤
Hardy et al. Management of the thrombotic risk associated with COVID-19: guidance for the hemostasis laboratory
Douxfils et al. Measurement of non-VKA oral anticoagulants versus classic ones: the appropriate use of hemostasis assays
CN109884326B (zh) 血小板聚集功能检测试剂盒
CN104076156A (zh) 活化部分凝血活酶时间测定法和活化部分凝血活酶时间测定用试剂盒
WO1994007145A1 (en) Method of assaying activity of blood coagulation factor xiii and reagent kit therefor
JP2011133396A (ja) 活性化部分トロンボプラスチン時間測定試薬、活性化部分トロンボプラスチン時間測定方法、及び血液凝固抑制物質の有無の判定方法
CN114277089B (zh) 一种达比加群的检测试剂及试剂盒
JP4399615B2 (ja) トロンビンの安定化手段および組成物
JP2004191367A (ja) トロンビン試薬及び検査試薬キット
JP2013145238A (ja) 血液凝固反応における血液凝固時間延長剤
JP6058726B2 (ja) 血液凝固反応における血液凝固時間延長剤
EP2316017B1 (en) Use of polyoxyethylene stearyl ether nonionic surfactants with magnesium ion selective electrodes
CN106350500B (zh) 凝血酶溶液
JPH0740959B2 (ja) ヒトの血漿中のタンパク質ｓの機能的活性を測定する方法および用品
CN120019280A (zh) 缺乏凝血因子xii的血液检体的凝血时间缩短剂
JP2011069718A (ja) 血液凝固反応における血液凝固時間延長剤
JP2008145278A (ja) ガストリン放出ペプチド前駆体の免疫学的測定方法
CN103558398A (zh) 一种抗肝素干扰的缺血修饰白蛋白检测试剂
JP2014197019A (ja) 血液凝固反応における血液凝固時間延長剤
Jensen et al. Influence of freeze-drying on the clotting properties of fibrinogen in plasma
CN106480007B (zh) 凝血酶溶液的稳定剂
CN106337044B (zh) 凝血酶溶液
JP2013246064A (ja) 検体希釈浮遊液およびそれを含む容器
JPH06324048A (ja) 血液凝固能検査用試薬及び血液凝固能の検査方法

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20111115

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20150520

Comment text: Request for Examination of Application

AMND Amendment
E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20170310

Patent event code: PE09021S01D

AMND Amendment
E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20171031

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20170310

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

X091 Application refused [patent]
AMND Amendment
PX0901 Re-examination

Patent event code: PX09011S01I

Patent event date: 20171031

Comment text: Decision to Refuse Application

Patent event code: PX09012R01I

Patent event date: 20170602

Comment text: Amendment to Specification, etc.

Patent event code: PX09012R01I

Patent event date: 20151204

Comment text: Amendment to Specification, etc.

PX0601 Decision of rejection after re-examination

Comment text: Decision to Refuse Application

Patent event code: PX06014S01D

Patent event date: 20180103

Comment text: Amendment to Specification, etc.

Patent event code: PX06012R01I

Patent event date: 20171130

Comment text: Decision to Refuse Application

Patent event code: PX06011S01I

Patent event date: 20171031

Comment text: Amendment to Specification, etc.

Patent event code: PX06012R01I

Patent event date: 20170602

Comment text: Notification of reason for refusal

Patent event code: PX06013S01I

Patent event date: 20170310

Comment text: Amendment to Specification, etc.

Patent event code: PX06012R01I

Patent event date: 20151204

X601 Decision of rejection after re-examination
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20180214