KR20100125245A - 아데닌 화합물의 제조 방법 - Google Patents
아데닌 화합물의 제조 방법 Download PDFInfo
- Publication number
- KR20100125245A KR20100125245A KR1020107017917A KR20107017917A KR20100125245A KR 20100125245 A KR20100125245 A KR 20100125245A KR 1020107017917 A KR1020107017917 A KR 1020107017917A KR 20107017917 A KR20107017917 A KR 20107017917A KR 20100125245 A KR20100125245 A KR 20100125245A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- formula
- acid
- compound represented
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JPJP-P-2008-007974 | 2008-01-17 | ||
JP2008007974 | 2008-01-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20100125245A true KR20100125245A (ko) | 2010-11-30 |
Family
ID=40885414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020107017917A KR20100125245A (ko) | 2008-01-17 | 2009-01-16 | 아데닌 화합물의 제조 방법 |
Country Status (8)
Country | Link |
---|---|
US (1) | US8865896B2 (ja) |
EP (1) | EP2246353A4 (ja) |
JP (1) | JP5577099B2 (ja) |
KR (1) | KR20100125245A (ja) |
CN (1) | CN102143964A (ja) |
CA (1) | CA2711769A1 (ja) |
IL (1) | IL206933A0 (ja) |
WO (1) | WO2009091032A1 (ja) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003271064B2 (en) * | 2002-09-27 | 2010-06-17 | Dainippon Sumitomo Pharma Co., Ltd. | Novel adenine compound and use thereof |
RU2397171C2 (ru) | 2004-03-26 | 2010-08-20 | ДАЙНИППОН СУМИТОМО ФАРМА Ко., ЛТД. | 9-замещенное производное 8-оксоаденина и лекарственное средство |
WO2008004948A1 (en) | 2006-07-05 | 2008-01-10 | Astrazeneca Ab | 8-oxoadenine derivatives acting as modulators of tlr7 |
TW200831105A (en) | 2006-12-14 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
JP5329444B2 (ja) | 2007-03-19 | 2013-10-30 | アストラゼネカ・アクチエボラーグ | Toll様受容体(tlr7)モジュレーターとしての9−置換−8−オキソ−アデニン化合物 |
DK2132209T3 (da) | 2007-03-19 | 2014-04-14 | Astrazeneca Ab | 9-substituerede 8-oxo-adeninforbindelser som modulatorer af tlr7 (toll-like receptor 7) |
US8044056B2 (en) * | 2007-03-20 | 2011-10-25 | Dainippon Sumitomo Pharma Co., Ltd. | Adenine compound |
TW200902018A (en) * | 2007-03-20 | 2009-01-16 | Dainippon Sumitomo Pharma Co | Novel adenine compound |
JP5400763B2 (ja) * | 2007-05-08 | 2014-01-29 | アストラゼネカ・アクチエボラーグ | 免疫調節特性を有するイミダゾキノリン類 |
PE20091236A1 (es) | 2007-11-22 | 2009-09-16 | Astrazeneca Ab | Derivados de pirimidina como immunomoduladores de tlr7 |
PE20091156A1 (es) | 2007-12-17 | 2009-09-03 | Astrazeneca Ab | Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo |
US20110054168A1 (en) * | 2008-01-17 | 2011-03-03 | Ayumu Kurimoto | Method for preparing adenine compound |
GB0908772D0 (en) | 2009-05-21 | 2009-07-01 | Astrazeneca Ab | New salts 756 |
JP2013512859A (ja) * | 2009-12-03 | 2013-04-18 | 大日本住友製薬株式会社 | トール様受容体(tlr)を介して作用するイミダゾキノリン |
CN103370317B (zh) | 2010-12-16 | 2015-10-07 | 阿斯利康(瑞典)有限公司 | 可用于治疗的咪唑并[4,5-c]喹啉-1-基衍生物 |
US8895570B2 (en) | 2010-12-17 | 2014-11-25 | Astrazeneca Ab | Purine derivatives |
TWI619704B (zh) | 2012-05-18 | 2018-04-01 | 大日本住友製藥股份有限公司 | 羧酸化合物 |
WO2017222946A1 (en) * | 2016-06-20 | 2017-12-28 | Vasade Biosciences | Adenylyl cyclase inhibitors, pharmaceutical compositions and methods of use thereof |
RU2748833C2 (ru) | 2016-11-28 | 2021-05-31 | Цзянсу Хэнжуй Медсин Ко., Лтд. | Производное пиразоло-гетероарила, способ его получения и медицинское применение |
CN110177793B (zh) | 2017-05-18 | 2021-12-21 | 江苏恒瑞医药股份有限公司 | 杂芳基并吡唑类衍生物、其制备方法及其在医药上的应用 |
CN108948016B (zh) * | 2017-05-19 | 2021-02-26 | 江苏恒瑞医药股份有限公司 | 嘌呤酮类衍生物、其制备方法及其在医药上的应用 |
CA3100873A1 (en) | 2018-05-25 | 2019-11-28 | Jiangsu Hengrui Medicine Co., Ltd. | Crystal form of hydrochloride of pyrazoloheteroaryl derivative and preparation method |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8404768L (sv) | 1983-09-27 | 1985-03-28 | Ceskoslovenska Akademie Ved | 9-(aminoalkyl)-8-hydroxiadeniner och sett for deras framstellning |
US5994361A (en) | 1994-06-22 | 1999-11-30 | Biochem Pharma | Substituted purinyl derivatives with immunomodulating activity |
PL319485A1 (en) | 1994-10-05 | 1997-08-04 | Chiroscience Ltd | Purinic and guanic compounds as pnp inhibitors |
ES2232871T3 (es) * | 1996-07-03 | 2005-06-01 | Sumitomo Pharmaceuticals Company, Limited | Nuevos derivados de purina. |
ES2205573T3 (es) | 1997-11-28 | 2004-05-01 | Sumitomo Pharmaceuticals Company, Limited | Nuevo compuestos heterociclicos. |
JPH11180981A (ja) | 1997-12-19 | 1999-07-06 | Sumitomo Pharmaceut Co Ltd | 複素環誘導体 |
TW572758B (en) | 1997-12-22 | 2004-01-21 | Sumitomo Pharma | Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives |
JP4160645B2 (ja) | 1997-12-24 | 2008-10-01 | 大日本住友製薬株式会社 | 新規アデニン誘導体及びその医薬用途 |
JP4189048B2 (ja) | 1997-12-26 | 2008-12-03 | 大日本住友製薬株式会社 | 複素環化合物 |
JP2000159767A (ja) | 1998-11-26 | 2000-06-13 | Sumitomo Pharmaceut Co Ltd | 8−ヒドロキシアデニン誘導体の新規製造法 |
CZ27399A3 (cs) | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
GB9924361D0 (en) * | 1999-10-14 | 1999-12-15 | Pfizer Ltd | Purine derivatives |
CZ20022353A3 (cs) * | 2000-01-07 | 2003-02-12 | Universitaire Instelling Antwerpen | Deriváty purinu, způsob jejich přípravy a jejich použití |
US20020128264A1 (en) * | 2000-07-07 | 2002-09-12 | Taylor Eve M. | Methods for treatment of conditions affected by activity of multidrug transporters |
US20020040032A1 (en) | 2000-07-07 | 2002-04-04 | Glasky Michelle S. | Methods for stimulation of synthesis of synaptophysin in the central nervous system |
ATE499103T1 (de) | 2000-07-07 | 2011-03-15 | Spectrum Pharmaceuticals Inc | Verfahren zur behandlung von arzneimittelinduzierter peripherer neuropathie und verwandten krankheitsformen |
US6887880B2 (en) * | 2000-11-20 | 2005-05-03 | Millennium Pharmaceuticals, Inc. | Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions, and method of use thereof |
JP4331944B2 (ja) | 2001-04-17 | 2009-09-16 | 大日本住友製薬株式会社 | 新規アデニン誘導体 |
ITRM20010465A1 (it) | 2001-07-31 | 2003-01-31 | Sigma Tau Ind Farmaceuti | Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam |
US20060252774A1 (en) * | 2002-05-02 | 2006-11-09 | Vatner Stephen F | Regulation of type 5 adenylyl cyclase for treatment of neurodegenerative and cardiac diseases |
AU2003271064B2 (en) | 2002-09-27 | 2010-06-17 | Dainippon Sumitomo Pharma Co., Ltd. | Novel adenine compound and use thereof |
JP2005089334A (ja) | 2003-09-12 | 2005-04-07 | Sumitomo Pharmaceut Co Ltd | 8−ヒドロキシアデニン化合物 |
RU2397171C2 (ru) | 2004-03-26 | 2010-08-20 | ДАЙНИППОН СУМИТОМО ФАРМА Ко., ЛТД. | 9-замещенное производное 8-оксоаденина и лекарственное средство |
JPWO2005092892A1 (ja) | 2004-03-26 | 2008-02-14 | 大日本住友製薬株式会社 | 8−オキソアデニン化合物 |
EP1888587A1 (en) | 2005-05-04 | 2008-02-20 | Pfizer Limited | 2-amido-6-amino-8-oxopurine derivatives as toll-like receptor modulators for the treatment of cancer and viral infections, such as hepatitis c |
CN101304748A (zh) * | 2005-08-22 | 2008-11-12 | 加利福尼亚大学董事会 | Tlr激动剂 |
TW200801003A (en) | 2005-09-16 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
US20090192153A1 (en) | 2005-09-22 | 2009-07-30 | Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan | Novel adenine compound |
JPWO2007034917A1 (ja) | 2005-09-22 | 2009-03-26 | 大日本住友製薬株式会社 | 新規なアデニン化合物 |
EP1939199A4 (en) * | 2005-09-22 | 2010-10-20 | Dainippon Sumitomo Pharma Co | NEW ADENINE CONNECTION |
TW200745114A (en) | 2005-09-22 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
JPWO2007034916A1 (ja) | 2005-09-22 | 2009-03-26 | 大日本住友製薬株式会社 | 新規アデニン化合物 |
US20090118263A1 (en) | 2005-09-22 | 2009-05-07 | Dainippon Sumitomo Pharma Co., Ltd. | Novel Adenine Compound |
ES2374455T3 (es) * | 2006-02-17 | 2012-02-16 | Pfizer Limited | Derivados de 3-deazapurinza como moduladores de tlr7. |
US20090281075A1 (en) | 2006-02-17 | 2009-11-12 | Pharmacopeia, Inc. | Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors |
WO2008004948A1 (en) * | 2006-07-05 | 2008-01-10 | Astrazeneca Ab | 8-oxoadenine derivatives acting as modulators of tlr7 |
ES2437871T3 (es) | 2006-07-07 | 2014-01-14 | Gilead Sciences, Inc. | Moduladores del receptor tipo toll 7 |
TW200831105A (en) | 2006-12-14 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
CL2008000496A1 (es) * | 2007-02-19 | 2008-09-22 | Smithkline Beecham Corp | Compuestos derivados de purina; procedimiento de preparacion de dichos compuestos; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades infecciosas, cancer, alergias y otras afecciones inflamatorias. |
DK2132209T3 (da) | 2007-03-19 | 2014-04-14 | Astrazeneca Ab | 9-substituerede 8-oxo-adeninforbindelser som modulatorer af tlr7 (toll-like receptor 7) |
JP5329444B2 (ja) | 2007-03-19 | 2013-10-30 | アストラゼネカ・アクチエボラーグ | Toll様受容体(tlr7)モジュレーターとしての9−置換−8−オキソ−アデニン化合物 |
TW200902018A (en) | 2007-03-20 | 2009-01-16 | Dainippon Sumitomo Pharma Co | Novel adenine compound |
US8044056B2 (en) | 2007-03-20 | 2011-10-25 | Dainippon Sumitomo Pharma Co., Ltd. | Adenine compound |
JP5400763B2 (ja) * | 2007-05-08 | 2014-01-29 | アストラゼネカ・アクチエボラーグ | 免疫調節特性を有するイミダゾキノリン類 |
US7968544B2 (en) * | 2007-06-29 | 2011-06-28 | Gilead Sciences, Inc. | Modulators of toll-like receptor 7 |
WO2009034386A1 (en) * | 2007-09-13 | 2009-03-19 | Astrazeneca Ab | Derivatives of adenine and 8-aza-adenine and uses thereof-796 |
WO2009062059A2 (en) | 2007-11-08 | 2009-05-14 | Pharmacopeia, Inc. | Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors |
PE20091156A1 (es) * | 2007-12-17 | 2009-09-03 | Astrazeneca Ab | Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo |
US20110054168A1 (en) * | 2008-01-17 | 2011-03-03 | Ayumu Kurimoto | Method for preparing adenine compound |
WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
WO2010033074A1 (en) | 2008-09-18 | 2010-03-25 | Astrazeneca Ab | Use of a tlr7 agonist for the treatment of cancer |
-
2009
- 2009-01-16 CN CN2009801094662A patent/CN102143964A/zh active Pending
- 2009-01-16 JP JP2009550058A patent/JP5577099B2/ja not_active Expired - Fee Related
- 2009-01-16 CA CA2711769A patent/CA2711769A1/en not_active Abandoned
- 2009-01-16 WO PCT/JP2009/050550 patent/WO2009091032A1/ja active Application Filing
- 2009-01-16 EP EP09703040A patent/EP2246353A4/en not_active Withdrawn
- 2009-01-16 US US12/863,291 patent/US8865896B2/en not_active Expired - Fee Related
- 2009-01-16 KR KR1020107017917A patent/KR20100125245A/ko not_active Application Discontinuation
-
2010
- 2010-07-11 IL IL206933A patent/IL206933A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
US8865896B2 (en) | 2014-10-21 |
CA2711769A1 (en) | 2009-07-23 |
EP2246353A1 (en) | 2010-11-03 |
JP5577099B2 (ja) | 2014-08-20 |
US20110046369A1 (en) | 2011-02-24 |
EP2246353A4 (en) | 2011-04-20 |
CN102143964A (zh) | 2011-08-03 |
WO2009091032A1 (ja) | 2009-07-23 |
JPWO2009091032A1 (ja) | 2011-05-26 |
IL206933A0 (en) | 2010-12-30 |
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |