KR20080072934A - 면역자극성 올리고리보뉴클레오티드 - Google Patents

면역자극성 올리고리보뉴클레오티드 Download PDF

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KR20080072934A
KR20080072934A KR1020087015356A KR20087015356A KR20080072934A KR 20080072934 A KR20080072934 A KR 20080072934A KR 1020087015356 A KR1020087015356 A KR 1020087015356A KR 20087015356 A KR20087015356 A KR 20087015356A KR 20080072934 A KR20080072934 A KR 20080072934A
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immunostimulatory
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rna
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Korean (ko)
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알렉산드라 포스바흐
조르그 볼머
그레이손 비 립포드
Original Assignee
콜리 파마슈티칼 게엠베하
콜레이 파마시티컬 그룹, 인코포레이티드
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Publication of KR20080072934A publication Critical patent/KR20080072934A/ko
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates

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  • Wood Science & Technology (AREA)
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  • Pulmonology (AREA)
  • Mycology (AREA)
  • Transplantation (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020087015356A 2005-11-25 2006-11-22 면역자극성 올리고리보뉴클레오티드 Ceased KR20080072934A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73952905P 2005-11-25 2005-11-25
US60/739,529 2005-11-25
US77898906P 2006-03-03 2006-03-03
US60/778,989 2006-03-03

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KR20080072934A true KR20080072934A (ko) 2008-08-07

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US (3) US7662949B2 (enExample)
EP (2) EP1957647B1 (enExample)
JP (1) JP4538522B2 (enExample)
KR (1) KR20080072934A (enExample)
CN (1) CN102517292B (enExample)
AU (2) AU2006318464B2 (enExample)
BR (2) BRPI0622298A8 (enExample)
CA (1) CA2630738C (enExample)
DK (1) DK1957647T3 (enExample)
ES (1) ES2536103T3 (enExample)
HK (1) HK1210212A1 (enExample)
PL (1) PL1957647T3 (enExample)
PT (1) PT1957647E (enExample)
SI (1) SI1957647T1 (enExample)
TW (1) TW200738877A (enExample)
WO (1) WO2007062107A2 (enExample)

Cited By (1)

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