KR20080027890A - 혈전성 증상의 치료에 유용한 ｐ2ｙ1 수용체의 ｎ-연결헤테로시클릭 길항제 - Google Patents
혈전성 증상의 치료에 유용한 ｐ2ｙ1 수용체의 ｎ-연결헤테로시클릭 길항제 Download PDFInfo
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- KR20080027890A KR20080027890A KR1020087002124A KR20087002124A KR20080027890A KR 20080027890 A KR20080027890 A KR 20080027890A KR 1020087002124 A KR1020087002124 A KR 1020087002124A KR 20087002124 A KR20087002124 A KR 20087002124A KR 20080027890 A KR20080027890 A KR 20080027890A
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- South Korea
- Prior art keywords
- substituted
- alkyl
- phenyl
- independently
- heterocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000011282 treatment Methods 0.000 title claims abstract description 47
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- 125000005842 heteroatom Chemical group 0.000 claims description 151
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 108
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- 238000000034 method Methods 0.000 claims description 85
- 125000003118 aryl group Chemical group 0.000 claims description 82
- 125000004432 carbon atom Chemical group C* 0.000 claims description 79
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- VFLHQFOPTSBWKI-UHFFFAOYSA-N 2-(7-methyl-2,3-dihydro-1h-cyclopenta[b]indol-4-yl)-n,n-diphenylbenzamide Chemical compound C1=2CCCC=2C2=CC(C)=CC=C2N1C1=CC=CC=C1C(=O)N(C=1C=CC=CC=1)C1=CC=CC=C1 VFLHQFOPTSBWKI-UHFFFAOYSA-N 0.000 claims description 3
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- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
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Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69459605P | 2005-06-27 | 2005-06-27 | |
| US60/694,596 | 2005-06-27 | ||
| US79706406P | 2006-05-02 | 2006-05-02 | |
| US60/797,064 | 2006-05-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20080027890A true KR20080027890A (ko) | 2008-03-28 |
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| US (2) | US7728008B2 (https=) |
| EP (1) | EP1896466B1 (https=) |
| JP (1) | JP2008543972A (https=) |
| KR (1) | KR20080027890A (https=) |
| AR (1) | AR056867A1 (https=) |
| AT (1) | ATE505468T1 (https=) |
| AU (1) | AU2006261828A1 (https=) |
| DE (1) | DE602006021306D1 (https=) |
| MX (1) | MX2007016501A (https=) |
| NO (1) | NO20076424L (https=) |
| PE (1) | PE20070016A1 (https=) |
| TW (1) | TW200726764A (https=) |
| WO (1) | WO2007002637A1 (https=) |
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| DE602006020871D1 (de) | 2005-06-27 | 2011-05-05 | Bristol Myers Squibb Co | Lineare harnstoffmimetika-antagonisten des p2y1-rezeptors zur behandlung von thromboseleiden |
| EP1899299B1 (en) * | 2005-06-27 | 2010-10-20 | Bristol-Myers Squibb Company | C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| WO2007002634A1 (en) * | 2005-06-27 | 2007-01-04 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| US7960569B2 (en) * | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| CA2799579A1 (en) | 2010-05-21 | 2011-11-24 | Intellikine, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| MX2014000648A (es) | 2011-07-19 | 2014-09-25 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y sus usos. |
| KR20140075693A (ko) | 2011-08-29 | 2014-06-19 | 인피니티 파마슈티칼스, 인코포레이티드 | 헤테로사이클릭 화합물 및 그의 용도 |
| WO2014022349A1 (en) * | 2012-08-01 | 2014-02-06 | Bristol-Myers Squibb Company | 7-hydroxy-spiropipiperidine indolinyl antagonists of p2y1 receptor |
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| US9540323B2 (en) | 2012-08-01 | 2017-01-10 | Bristol-Myers Squibb Company | 7-hydroxy-indolinyl antagonists of P2Y1 receptor |
| JP2016501203A (ja) | 2012-11-20 | 2016-01-18 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インドールアミン２，３−ジオキシゲナーゼの阻害剤として有用な化合物 |
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| JP7542538B2 (ja) | 2018-09-18 | 2024-08-30 | ニカング セラピューティクス， インコーポレイテッド | Ｓｒｃホモロジー－２ホスファターゼ阻害剤としての縮合三環式環誘導体 |
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2006
- 2006-06-26 AR ARP060102745A patent/AR056867A1/es unknown
- 2006-06-26 MX MX2007016501A patent/MX2007016501A/es not_active Application Discontinuation
- 2006-06-26 EP EP06774067A patent/EP1896466B1/en active Active
- 2006-06-26 AT AT06774067T patent/ATE505468T1/de not_active IP Right Cessation
- 2006-06-26 KR KR1020087002124A patent/KR20080027890A/ko not_active Withdrawn
- 2006-06-26 DE DE602006021306T patent/DE602006021306D1/de active Active
- 2006-06-26 US US11/474,888 patent/US7728008B2/en active Active
- 2006-06-26 JP JP2008519471A patent/JP2008543972A/ja active Pending
- 2006-06-26 WO PCT/US2006/024914 patent/WO2007002637A1/en not_active Ceased
- 2006-06-26 TW TW095122981A patent/TW200726764A/zh unknown
- 2006-06-26 AU AU2006261828A patent/AU2006261828A1/en not_active Abandoned
- 2006-06-27 PE PE2006000739A patent/PE20070016A1/es not_active Application Discontinuation
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2007
- 2007-12-14 NO NO20076424A patent/NO20076424L/no not_active Application Discontinuation
-
2010
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Also Published As
| Publication number | Publication date |
|---|---|
| TW200726764A (en) | 2007-07-16 |
| JP2008543972A (ja) | 2008-12-04 |
| ATE505468T1 (de) | 2011-04-15 |
| MX2007016501A (es) | 2008-03-06 |
| WO2007002637B1 (en) | 2007-03-01 |
| WO2007002637A1 (en) | 2007-01-04 |
| US7728008B2 (en) | 2010-06-01 |
| US20060293281A1 (en) | 2006-12-28 |
| EP1896466A1 (en) | 2008-03-12 |
| US20100197716A1 (en) | 2010-08-05 |
| NO20076424L (no) | 2008-03-18 |
| US8329718B2 (en) | 2012-12-11 |
| DE602006021306D1 (https=) | 2011-05-26 |
| AR056867A1 (es) | 2007-10-31 |
| AU2006261828A1 (en) | 2007-01-04 |
| EP1896466B1 (en) | 2011-04-13 |
| PE20070016A1 (es) | 2007-02-11 |
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