KR20070112785A - 비드-기초 서열화를 위한 시약, 방법, 및 라이브러리 - Google Patents
비드-기초 서열화를 위한 시약, 방법, 및 라이브러리 Download PDFInfo
- Publication number
- KR20070112785A KR20070112785A KR1020077019819A KR20077019819A KR20070112785A KR 20070112785 A KR20070112785 A KR 20070112785A KR 1020077019819 A KR1020077019819 A KR 1020077019819A KR 20077019819 A KR20077019819 A KR 20077019819A KR 20070112785 A KR20070112785 A KR 20070112785A
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- South Korea
- Prior art keywords
- probe
- template
- oligonucleotide
- nucleotide
- sequence
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2533/00—Reactions characterised by the enzymatic reaction principle used
- C12Q2533/10—Reactions characterised by the enzymatic reaction principle used the purpose being to increase the length of an oligonucleotide strand
- C12Q2533/107—Probe or oligonucleotide ligation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/165—Mathematical modelling, e.g. logarithm, ratio
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/10—Detection mode being characterised by the assay principle
- C12Q2565/102—Multiple non-interacting labels
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/10—Detection mode being characterised by the assay principle
- C12Q2565/137—Chromatographic separation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/50—Detection characterised by immobilisation to a surface
- C12Q2565/513—Detection characterised by immobilisation to a surface characterised by the pattern of the arrayed oligonucleotides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/50—Detection characterised by immobilisation to a surface
- C12Q2565/518—Detection characterised by immobilisation to a surface characterised by the immobilisation of the nucleic acid sample or target
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/50—Detection characterised by immobilisation to a surface
- C12Q2565/537—Detection characterised by immobilisation to a surface characterised by the capture oligonucleotide acting as a primer
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- General Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Composite Materials (AREA)
- Evolutionary Biology (AREA)
- Databases & Information Systems (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioethics (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64929405P | 2005-02-01 | 2005-02-01 | |
| US60/649,294 | 2005-02-01 | ||
| US65659905P | 2005-02-25 | 2005-02-25 | |
| US60/656,599 | 2005-02-25 | ||
| US67374905P | 2005-04-21 | 2005-04-21 | |
| US60/673,749 | 2005-04-21 | ||
| US69954105P | 2005-07-15 | 2005-07-15 | |
| US60/699,541 | 2005-07-15 | ||
| US72252605P | 2005-09-30 | 2005-09-30 | |
| US60/722,526 | 2005-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20070112785A true KR20070112785A (ko) | 2007-11-27 |
Family
ID=36777972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077019819A Ceased KR20070112785A (ko) | 2005-02-01 | 2006-02-01 | 비드-기초 서열화를 위한 시약, 방법, 및 라이브러리 |
Country Status (7)
| Country | Link |
|---|---|
| US (10) | US20080003571A1 (enExample) |
| EP (9) | EP1844162B1 (enExample) |
| JP (1) | JP2008528040A (enExample) |
| KR (1) | KR20070112785A (enExample) |
| AU (1) | AU2006210553A1 (enExample) |
| CA (1) | CA2596496A1 (enExample) |
| WO (1) | WO2006084132A2 (enExample) |
Families Citing this family (450)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2458802C (en) | 2001-09-06 | 2016-06-07 | Genomic Profiling Systems, Inc. | Rapid and sensitive detection of molecules |
| JP4691014B2 (ja) | 2003-02-26 | 2011-06-01 | カリダ ゲノミクス,インコーポレーテッド | ハイブリダイゼーションによるランダムアレイdna分析 |
| US10533998B2 (en) | 2008-07-18 | 2020-01-14 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US7622296B2 (en) | 2004-05-28 | 2009-11-24 | Wafergen, Inc. | Apparatus and method for multiplex analysis |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| EP1844162B1 (en) | 2005-02-01 | 2014-10-15 | Applied Biosystems, LLC | Method for identifying a sequence in a polynucleotide |
| US20090264299A1 (en) | 2006-02-24 | 2009-10-22 | Complete Genomics, Inc. | High throughput genome sequencing on DNA arrays |
| EP1907571B1 (en) | 2005-06-15 | 2017-04-26 | Complete Genomics Inc. | Nucleic acid analysis by random mixtures of non-overlapping fragments |
| US9057046B2 (en) * | 2005-09-26 | 2015-06-16 | Rapid Micro Biosystems, Inc. | Cassette containing growth medium |
| EP3913375A1 (en) | 2006-01-11 | 2021-11-24 | Bio-Rad Laboratories, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| AU2007237909A1 (en) | 2006-04-19 | 2007-10-25 | Applied Biosystems, Llc. | Reagents, methods, and libraries for gel-free bead-based sequencing |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| EP2021113A2 (en) * | 2006-05-11 | 2009-02-11 | Raindance Technologies, Inc. | Microfluidic devices |
| WO2008027558A2 (en) | 2006-08-31 | 2008-03-06 | Codon Devices, Inc. | Iterative nucleic acid assembly using activation of vector-encoded traits |
| US7754429B2 (en) | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
| US7910302B2 (en) * | 2006-10-27 | 2011-03-22 | Complete Genomics, Inc. | Efficient arrays of amplified polynucleotides |
| US20090111706A1 (en) | 2006-11-09 | 2009-04-30 | Complete Genomics, Inc. | Selection of dna adaptor orientation by amplification |
| AU2006249239B2 (en) * | 2006-12-07 | 2010-02-18 | Canon Kabushiki Kaisha | A method of ordering and presenting images with smooth metadata transitions |
| EP2126765B1 (en) * | 2007-01-26 | 2011-08-24 | Illumina Inc. | Nucleic acid sequencing system and method |
| US12421546B2 (en) | 2007-01-26 | 2025-09-23 | Illumina, Inc. | Nucleic acid sequencing system |
| US8315817B2 (en) | 2007-01-26 | 2012-11-20 | Illumina, Inc. | Independently removable nucleic acid sequencing system and method |
| US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| WO2008151127A1 (en) * | 2007-06-04 | 2008-12-11 | President And Fellows Of Harvard College | Compounds and methods for chemical ligation |
| DK2171088T3 (en) * | 2007-06-19 | 2016-01-25 | Stratos Genomics Inc | Nucleic acid sequencing in a high yield by expansion |
| EP2181204A2 (en) * | 2007-08-23 | 2010-05-05 | Applied Biosystems Inc. | Methods of modifying support surfaces for the immobilization of particles and the use of the immobilized particles for analyzing nucleic acids |
| US20090062132A1 (en) | 2007-08-29 | 2009-03-05 | Borner Scott R | Alternative nucleic acid sequencing methods |
| WO2009046149A1 (en) * | 2007-10-01 | 2009-04-09 | Applied Biosystems Inc. | Chase ligation sequencing |
| US20090139311A1 (en) | 2007-10-05 | 2009-06-04 | Applied Biosystems Inc. | Biological Analysis Systems, Devices, and Methods |
| WO2009052214A2 (en) | 2007-10-15 | 2009-04-23 | Complete Genomics, Inc. | Sequence analysis using decorated nucleic acids |
| US8415099B2 (en) | 2007-11-05 | 2013-04-09 | Complete Genomics, Inc. | Efficient base determination in sequencing reactions |
| US8298768B2 (en) | 2007-11-29 | 2012-10-30 | Complete Genomics, Inc. | Efficient shotgun sequencing methods |
| DK2215209T3 (en) | 2007-10-30 | 2018-09-03 | Complete Genomics Inc | DEVICE FOR HIGH-THROUGHPUT SEQUENCE OF NUCLEIC ACIDS |
| US20090264298A1 (en) * | 2007-11-06 | 2009-10-22 | Ambergen, Inc. | Methods for enriching subpopulations |
| US8017338B2 (en) | 2007-11-20 | 2011-09-13 | Life Technologies Corporation | Reversible di-nucleotide terminator sequencing |
| US8592150B2 (en) | 2007-12-05 | 2013-11-26 | Complete Genomics, Inc. | Methods and compositions for long fragment read sequencing |
| WO2009097368A2 (en) | 2008-01-28 | 2009-08-06 | Complete Genomics, Inc. | Methods and compositions for efficient base calling in sequencing reactions |
| US20110003701A1 (en) * | 2008-02-27 | 2011-01-06 | 454 Life Sciences Corporation | System and method for improved processing of nucleic acids for production of sequencable libraries |
| EP2279268A4 (en) | 2008-04-04 | 2011-12-07 | Life Technologies Corp | SCANNING SYSTEM AND METHOD OF IMAGING AND SEQUENCING |
| US20090269771A1 (en) * | 2008-04-24 | 2009-10-29 | Life Technologies Corporation | Method of sequencing and mapping target nucleic acids |
| US8058414B2 (en) * | 2008-04-29 | 2011-11-15 | Life Technologies Corporation | Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded nucleic acids from a nucleic acid template and methods of use |
| US8911948B2 (en) * | 2008-04-30 | 2014-12-16 | Integrated Dna Technologies, Inc. | RNase H-based assays utilizing modified RNA monomers |
| EP2644707B1 (en) | 2008-04-30 | 2015-06-03 | Integrated Dna Technologies, Inc. | RNase-H-based assays utilizing modified RNA monomers |
| WO2009137366A2 (en) * | 2008-05-06 | 2009-11-12 | Kollmorgen Corporation | Genetic sequencer incorporating fluorescence microscopy |
| US8198028B2 (en) * | 2008-07-02 | 2012-06-12 | Illumina Cambridge Limited | Using populations of beads for the fabrication of arrays on surfaces |
| WO2010009365A1 (en) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Droplet libraries |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US8173198B2 (en) | 2008-07-23 | 2012-05-08 | Life Technologies Corporation | Deposition of metal oxides onto surfaces as an immobilization vehicle for carboxylated or phophated particles or polymers |
| US20100227327A1 (en) * | 2008-08-08 | 2010-09-09 | Xiaoliang Sunney Xie | Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides |
| US20100036110A1 (en) * | 2008-08-08 | 2010-02-11 | Xiaoliang Sunney Xie | Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides |
| US8530156B2 (en) * | 2008-08-08 | 2013-09-10 | President And Fellows Of Harvard College | Chemically cleavable phosphoramidite linkers for sequencing by ligation |
| WO2010028366A2 (en) * | 2008-09-05 | 2010-03-11 | Life Technologies Corporation | Methods and systems for nucleic acid sequencing validation, calibration and normalization |
| CA2738317C (en) | 2008-09-24 | 2020-01-14 | Straus Holdings Inc. | Imaging analyzer for testing analytes |
| KR20100042082A (ko) * | 2008-10-15 | 2010-04-23 | 삼성전자주식회사 | 신호물질의 밀도가 증가되어 있는 고체 지지체, 그를 포함하는 키트 및 그를 이용한 표적물질 검출 방법 |
| US20100112588A1 (en) * | 2008-11-04 | 2010-05-06 | Caerus Molecular Diagnostics, Inc. | Methods for sanger sequencing using particle associated clonal amplicons and highly parallel electrophoretic size-based separation |
| AU2010213510B2 (en) * | 2009-02-16 | 2014-05-01 | Epicentre Technologies Corporation | Template-independent ligation of single-stranded DNA |
| WO2010111231A1 (en) | 2009-03-23 | 2010-09-30 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| WO2010111656A2 (en) * | 2009-03-27 | 2010-09-30 | Life Technologies Corporation | Systems and methods for assessing images |
| GB0907372D0 (en) | 2009-04-29 | 2009-06-10 | Invitrogen Dynal As | Particles |
| US12129514B2 (en) | 2009-04-30 | 2024-10-29 | Molecular Loop Biosolutions, Llc | Methods and compositions for evaluating genetic markers |
| JP2012525147A (ja) | 2009-04-30 | 2012-10-22 | グッド スタート ジェネティクス, インコーポレイテッド | 遺伝マーカーを評価するための方法および組成物 |
| KR20100122366A (ko) * | 2009-05-12 | 2010-11-22 | 삼성전자주식회사 | 핵산 서열의 결정을 위한 자성 입자 및 이를 이용한 핵산 서열 결정 방법 |
| US8574835B2 (en) * | 2009-05-29 | 2013-11-05 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
| US9524369B2 (en) | 2009-06-15 | 2016-12-20 | Complete Genomics, Inc. | Processing and analysis of complex nucleic acid sequence data |
| DK2456892T3 (en) | 2009-07-24 | 2014-12-08 | Illumina Inc | Procedure for sequencing of a polynukleotidskabelon |
| WO2011026102A1 (en) | 2009-08-31 | 2011-03-03 | Life Technologies Corporation | Methods of bead manipulation and forming bead arrays |
| WO2011031895A2 (en) | 2009-09-09 | 2011-03-17 | Life Technologies Corporation | Systems and methods for identifying microparticles |
| WO2011044437A2 (en) | 2009-10-09 | 2011-04-14 | Stc.Unm | Polony sequencing methods |
| US9234239B2 (en) | 2009-10-23 | 2016-01-12 | Life Technologies Corporation | Systems and methods for error correction in DNA sequencing |
| WO2011053845A2 (en) * | 2009-10-30 | 2011-05-05 | Illumina, Inc. | Microvessels, microparticles, and methods of manufacturing and using the same |
| WO2011060014A1 (en) * | 2009-11-13 | 2011-05-19 | Integrated Dna Technologies, Inc. | Small rna detection assays |
| EP4484577A3 (en) | 2010-02-12 | 2025-03-26 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US20110257031A1 (en) | 2010-02-12 | 2011-10-20 | Life Technologies Corporation | Nucleic acid, biomolecule and polymer identifier codes |
| WO2011103467A2 (en) * | 2010-02-19 | 2011-08-25 | Life Technologies Corporation | Methods and systems for nucleic acid sequencing validation, calibration and normalization |
| US9499860B2 (en) | 2010-02-19 | 2016-11-22 | The Ohio State University | Primers and methods for nucleic acid amplification |
| US10030045B2 (en) | 2010-02-19 | 2018-07-24 | Ohio State Innovation Foundation | Primers and methods for nucleic acid amplification |
| US20110257385A1 (en) | 2010-02-23 | 2011-10-20 | Life Technologies Corporation | Methods for flip-strand immobilizing and sequencing nucleic acids |
| US8603303B2 (en) * | 2010-03-15 | 2013-12-10 | International Business Machines Corporation | Nanopore based device for cutting long DNA molecules into fragments |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| WO2011143525A2 (en) * | 2010-05-13 | 2011-11-17 | Life Technologies Corporation | Computational methods for translating a sequence of multi-base color calls to a sequence of bases |
| EP2390351A1 (en) | 2010-05-27 | 2011-11-30 | Centre National de la Recherche Scientifique (CNRS) | Method of DNA sequencing by hybridisation |
| EP2390350A1 (en) | 2010-05-27 | 2011-11-30 | Centre National de la Recherche Scientifique (CNRS) | Method of DNA sequencing by polymerisation |
| US9268903B2 (en) | 2010-07-06 | 2016-02-23 | Life Technologies Corporation | Systems and methods for sequence data alignment quality assessment |
| EP2405017A1 (en) | 2010-07-06 | 2012-01-11 | Alacris Theranostics GmbH | Method for nucleic acid sequencing |
| EP2622103B2 (en) | 2010-09-30 | 2022-11-16 | Bio-Rad Laboratories, Inc. | Sandwich assays in droplets |
| GB2499340B (en) | 2010-10-04 | 2015-10-28 | Genapsys Inc | Methods for sequencing nucleic acids |
| US9184099B2 (en) | 2010-10-04 | 2015-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Biosensor devices, systems and methods therefor |
| US9399217B2 (en) | 2010-10-04 | 2016-07-26 | Genapsys, Inc. | Chamber free nanoreactor system |
| US20150218639A1 (en) | 2014-01-17 | 2015-08-06 | Northwestern University | Biomarkers predictive of predisposition to depression and response to treatment |
| US10093981B2 (en) | 2010-10-19 | 2018-10-09 | Northwestern University | Compositions and methods for identifying depressive disorders |
| US10233501B2 (en) | 2010-10-19 | 2019-03-19 | Northwestern University | Biomarkers predictive of predisposition to depression and response to treatment |
| US20150225792A1 (en) | 2014-01-17 | 2015-08-13 | Northwestern University | Compositions and methods for identifying depressive disorders |
| WO2012061818A1 (en) | 2010-11-05 | 2012-05-10 | Life Technologies Corporation | Flowcells and flowcell reaction chambers |
| AU2011338841B2 (en) | 2010-11-12 | 2017-02-16 | Gen9, Inc. | Methods and devices for nucleic acids synthesis |
| EP2637780B1 (en) | 2010-11-12 | 2022-02-09 | Gen9, Inc. | Protein arrays and methods of using and making the same |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| EP2643783A2 (en) | 2010-11-22 | 2013-10-02 | Life Technologies Corporation | Model-based residual correction of intensities |
| EP3709303A1 (en) | 2010-12-14 | 2020-09-16 | Life Technologies Corporation | Systems and methods for run-time sequencing run quality monitoring |
| WO2012099832A2 (en) * | 2011-01-17 | 2012-07-26 | Life Technologies Corporation | Enzymatic ligation of nucleic acids |
| WO2013082164A1 (en) | 2011-11-28 | 2013-06-06 | Life Technologies Corporation | Enhanced ligation reactions |
| US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
| JP5858415B2 (ja) * | 2011-01-05 | 2016-02-10 | 国立大学法人埼玉大学 | mRNA/cDNA−タンパク質連結体作製用リンカーとそれを用いたヌクレオチド−タンパク質連結体の精製方法 |
| WO2012099896A2 (en) | 2011-01-17 | 2012-07-26 | Life Technologies Corporation | Workflow for detection of ligands using nucleic acids |
| US9738930B2 (en) | 2011-01-28 | 2017-08-22 | The Broad Institute, Inc. | Paired end bead amplification and high throughput sequencing |
| US8986524B2 (en) | 2011-01-28 | 2015-03-24 | International Business Machines Corporation | DNA sequence using multiple metal layer structure with different organic coatings forming different transient bondings to DNA |
| US20120193231A1 (en) | 2011-01-28 | 2012-08-02 | International Business Machines Corporation | Dna sequencing using multiple metal layer structure with organic coatings forming transient bonding to dna bases |
| US8852407B2 (en) | 2011-01-28 | 2014-10-07 | International Business Machines Corporation | Electron beam sculpting of tunneling junction for nanopore DNA sequencing |
| WO2012109600A2 (en) | 2011-02-11 | 2012-08-16 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
| JP5705579B2 (ja) | 2011-02-18 | 2015-04-22 | 株式会社日立ハイテクノロジーズ | 分析装置 |
| US9150852B2 (en) | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
| US8399262B2 (en) * | 2011-03-23 | 2013-03-19 | Darrel A. Mazzari | Biosensor |
| WO2012135053A2 (en) | 2011-03-25 | 2012-10-04 | Integrated Dna Technologies, Inc. | Rnase h-based assays utilizing modified rna monomers |
| EP2505665A1 (en) | 2011-03-31 | 2012-10-03 | Queen Mary And Westfield College, University Of London | Cancer markers |
| US9121047B2 (en) | 2011-04-07 | 2015-09-01 | Life Technologies Corporation | System and methods for making and processing emulsions |
| WO2012139125A2 (en) | 2011-04-07 | 2012-10-11 | Life Technologies Corporation | System and methods for making and processing emulsions |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| EP2710146A2 (en) | 2011-05-18 | 2014-03-26 | Life Technologies Corporation | Chromosome conformation analysis |
| US9926596B2 (en) | 2011-05-27 | 2018-03-27 | Genapsys, Inc. | Systems and methods for genetic and biological analysis |
| US8585973B2 (en) | 2011-05-27 | 2013-11-19 | The Board Of Trustees Of The Leland Stanford Junior University | Nano-sensor array |
| EP2714935B1 (en) | 2011-05-27 | 2017-03-15 | Genapsys Inc. | Systems and methods for genetic and biological analysis |
| US9752176B2 (en) | 2011-06-15 | 2017-09-05 | Ginkgo Bioworks, Inc. | Methods for preparative in vitro cloning |
| US20120330559A1 (en) | 2011-06-21 | 2012-12-27 | Life Technologies Corporation | Systems and methods for hybrid assembly of nucleic acid sequences |
| US8920751B2 (en) | 2011-07-08 | 2014-12-30 | Life Technologies Corporation | Automated enrichment for nucleic acid sequencing |
| US10559048B2 (en) | 2011-07-13 | 2020-02-11 | The Multiple Myeloma Research Foundation, Inc. | Methods for data collection and distribution |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| US9670538B2 (en) | 2011-08-05 | 2017-06-06 | Ibis Biosciences, Inc. | Nucleic acid sequencing by electrochemical detection |
| WO2013022961A1 (en) | 2011-08-08 | 2013-02-14 | 3The Broad Institute | Compositions and methods for co-amplifying subsequences of a nucleic acid fragment sequence |
| AU2012300401B2 (en) | 2011-08-26 | 2018-02-08 | Ginkgo Bioworks, Inc. | Compositions and methods for high fidelity assembly of nucleic acids |
| US20130073214A1 (en) | 2011-09-20 | 2013-03-21 | Life Technologies Corporation | Systems and methods for identifying sequence variation |
| JP2014531908A (ja) | 2011-10-14 | 2014-12-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 構造アッセンブリによる配列決定 |
| CA2852665A1 (en) | 2011-10-17 | 2013-04-25 | Good Start Genetics, Inc. | Analysis methods |
| MX368123B (es) | 2011-11-07 | 2019-09-19 | Rapid Micro Biosystems Inc | Cassette para pruebas de esterilidad. |
| WO2013082619A1 (en) | 2011-12-01 | 2013-06-06 | Genapsys, Inc. | Systems and methods for high efficiency electronic sequencing and detection |
| JP6093498B2 (ja) * | 2011-12-13 | 2017-03-08 | 株式会社日立ハイテクノロジーズ | 核酸増幅方法 |
| US20130189679A1 (en) | 2011-12-20 | 2013-07-25 | The Regents Of The University Of Michigan | Pseudogenes and uses thereof |
| WO2013096799A1 (en) | 2011-12-22 | 2013-06-27 | Ibis Biosciences, Inc. | Systems and methods for isolating nucleic acids from cellular samples |
| WO2013096838A2 (en) | 2011-12-22 | 2013-06-27 | Ibis Biosciences, Inc. | Systems and methods for isolating nucleic acids |
| ES2991004T3 (es) | 2011-12-22 | 2024-12-02 | Harvard College | Métodos para la detección de analitos |
| ES2952728T3 (es) | 2011-12-22 | 2023-11-03 | Harvard College | Métodos para la detección de analitos |
| WO2013096819A2 (en) | 2011-12-22 | 2013-06-27 | Ibis Biosciences, Inc. | Macromolecule positioning by electrical potential |
| WO2013102091A1 (en) | 2011-12-28 | 2013-07-04 | Ibis Biosciences, Inc. | Nucleic acid ligation systems and methods |
| WO2013102081A2 (en) | 2011-12-29 | 2013-07-04 | Ibis Biosciences, Inc. | Macromolecule delivery to nanowells |
| WO2013101743A2 (en) | 2011-12-30 | 2013-07-04 | Abbott Molecular, Inc. | Microorganism nucelic acid purification from host samples |
| JP2015503356A (ja) | 2012-01-06 | 2015-02-02 | バイオミクス, インコーポレイテッドViomics, Inc. | 末梢血中で、がんによって変化したrnaを検出するシステムおよび方法 |
| US9822417B2 (en) | 2012-01-09 | 2017-11-21 | Oslo Universitetssykehus Hf | Methods and biomarkers for analysis of colorectal cancer |
| WO2013106737A1 (en) | 2012-01-13 | 2013-07-18 | Data2Bio | Genotyping by next-generation sequencing |
| HK1205558A1 (en) | 2012-02-21 | 2015-12-18 | Oslo Universitetssykehus Hf | Methods and biomarkers for detection and prognosis of cervical cancer |
| AU2013229151A1 (en) | 2012-03-06 | 2014-09-25 | Aarhus University | Gene signatures associated with efficacy of postmastectomy radiotherapy in breast cancer |
| US9150853B2 (en) | 2012-03-21 | 2015-10-06 | Gen9, Inc. | Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis |
| US9732387B2 (en) | 2012-04-03 | 2017-08-15 | The Regents Of The University Of Michigan | Biomarker associated with irritable bowel syndrome and Crohn's disease |
| US10029915B2 (en) | 2012-04-04 | 2018-07-24 | International Business Machines Corporation | Functionally switchable self-assembled coating compound for controlling translocation of molecule through nanopores |
| US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
| US8812422B2 (en) | 2012-04-09 | 2014-08-19 | Good Start Genetics, Inc. | Variant database |
| US10227635B2 (en) | 2012-04-16 | 2019-03-12 | Molecular Loop Biosolutions, Llc | Capture reactions |
| US10407707B2 (en) | 2012-04-16 | 2019-09-10 | Rapid Micro Biosystems, Inc. | Cell culturing device |
| US20130281308A1 (en) * | 2012-04-24 | 2013-10-24 | Gen9, Inc. | Methods for sorting nucleic acids and preparative in vitro cloning |
| EP2841601B1 (en) | 2012-04-24 | 2019-03-06 | Gen9, Inc. | Methods for sorting nucleic acids and multiplexed preparative in vitro cloning |
| ES2683707T3 (es) | 2012-05-02 | 2018-09-27 | Ibis Biosciences, Inc. | Secuenciación de ADN |
| EP3789502A1 (en) | 2012-05-02 | 2021-03-10 | Ibis Biosciences, Inc. | Dna sequencing |
| EP2844767A4 (en) | 2012-05-02 | 2015-11-18 | Ibis Biosciences Inc | SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCING |
| WO2013166304A1 (en) | 2012-05-02 | 2013-11-07 | Ibis Biosciences, Inc. | Dna sequencing |
| WO2013184754A2 (en) | 2012-06-05 | 2013-12-12 | President And Fellows Of Harvard College | Spatial sequencing of nucleic acids using dna origami probes |
| US20150191719A1 (en) | 2012-06-25 | 2015-07-09 | Gen9, Inc. | Methods for Nucleic Acid Assembly and High Throughput Sequencing |
| WO2014005076A2 (en) | 2012-06-29 | 2014-01-03 | The Regents Of The University Of Michigan | Methods and biomarkers for detection of kidney disorders |
| JP6297546B2 (ja) | 2012-06-29 | 2018-03-20 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 結合磁性粒子及び未結合磁性粒子の処理 |
| FR2993282B1 (fr) | 2012-07-13 | 2017-11-10 | Expanscience Lab | Procede d'identification de marqueurs moleculaires de la peau d'enfant |
| EP2692870A1 (en) | 2012-08-03 | 2014-02-05 | Alacris Theranostics GmbH | Method for nucleic acid amplification |
| US9725768B2 (en) | 2012-08-31 | 2017-08-08 | Biovest International, Inc. | Methods for producing high-fidelity autologous idiotype vaccines |
| JP5663541B2 (ja) * | 2012-09-19 | 2015-02-04 | 株式会社日立ハイテクノロジーズ | 反応容器,並列処理装置、及びシーケンサ |
| DK3511423T4 (da) | 2012-10-17 | 2024-07-29 | Spatial Transcriptomics Ab | Fremgangsmåder og produkt til optimering af lokaliseret eller rumlig detektion af genekspression i en vævsprøve |
| US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
| EP2912182B1 (en) | 2012-10-23 | 2021-12-08 | Caris Science, Inc. | Aptamers and uses thereof |
| EP2743354A1 (en) | 2012-12-13 | 2014-06-18 | Alacris Theranostics GmbH | Low melting temperature primer |
| WO2014100434A1 (en) | 2012-12-19 | 2014-06-26 | Caris Science, Inc. | Compositions and methods for aptamer screening |
| US9791453B2 (en) | 2012-12-26 | 2017-10-17 | International Business Machines Corporation | Methods for determining binding capability of target ligands with G protein-coupled receptors using translocation through nanochannels |
| US8835362B2 (en) | 2012-12-26 | 2014-09-16 | International Business Machines Corporation | Modifying single proteins (GPCR), ligands, and nanopore surfaces to create binding-induced molecular changes of protein-ligand complexes detected in nanochannel translocation |
| WO2014113815A1 (en) | 2013-01-21 | 2014-07-24 | Life Technologies Corporation | Systems and methods for gene expression analysis |
| FR3001889B1 (fr) | 2013-02-11 | 2021-02-12 | Expanscience Lab | Utilisation d'une composition comprenant un perseose d'avocat dans la protection des cellules souches epidermiques . |
| JP5978147B2 (ja) * | 2013-02-12 | 2016-08-24 | 株式会社日立ハイテクノロジーズ | 生体物質分析装置 |
| EP2964789A4 (en) * | 2013-03-06 | 2016-11-02 | Ohio State Innovation Foundation | ISOTHERMIC NUCLEIC ACID AMPLIFICATION AND LIBRARY GENERATION AND CLONING GENERATION IN SEQUENCING |
| US9289502B2 (en) | 2013-03-08 | 2016-03-22 | Emerald Therapeutics, Inc. | Preparation of oligo conjugates |
| US10138509B2 (en) | 2013-03-12 | 2018-11-27 | President And Fellows Of Harvard College | Method for generating a three-dimensional nucleic acid containing matrix |
| US20140272967A1 (en) | 2013-03-13 | 2014-09-18 | Abbott Molecular Inc. | Systems and methods for isolating nucleic acids |
| WO2014152421A1 (en) | 2013-03-14 | 2014-09-25 | Good Start Genetics, Inc. | Methods for analyzing nucleic acids |
| WO2014160117A1 (en) | 2013-03-14 | 2014-10-02 | Abbott Molecular Inc. | Multiplex methylation-specific amplification systems and methods |
| WO2014152937A1 (en) | 2013-03-14 | 2014-09-25 | Ibis Biosciences, Inc. | Nucleic acid control panels |
| ES2716094T3 (es) | 2013-03-15 | 2019-06-10 | Ibis Biosciences Inc | Métodos para analizar la contaminación en la secuenciación del ADN |
| CN105358709B (zh) | 2013-03-15 | 2018-12-07 | 雅培分子公司 | 用于检测基因组拷贝数变化的系统和方法 |
| CA2896879C (en) | 2013-03-15 | 2020-09-22 | Genapsys, Inc. | Systems and methods for biological analysis |
| US9046511B2 (en) | 2013-04-18 | 2015-06-02 | International Business Machines Corporation | Fabrication of tunneling junction for nanopore DNA sequencing |
| US10160995B2 (en) | 2013-05-13 | 2018-12-25 | Qiagen Waltham, Inc. | Analyte enrichment methods and compositions |
| WO2014197377A2 (en) | 2013-06-03 | 2014-12-11 | Good Start Genetics, Inc. | Methods and systems for storing sequence read data |
| US9188578B2 (en) | 2013-06-19 | 2015-11-17 | Globalfoundries Inc. | Nanogap device with capped nanowire structures |
| US9182369B2 (en) | 2013-06-19 | 2015-11-10 | Globalfoundries Inc. | Manufacturable sub-3 nanometer palladium gap devices for fixed electrode tunneling recognition |
| EP4234716A3 (en) | 2013-06-25 | 2023-12-06 | Prognosys Biosciences, Inc. | Methods for determining spatial patterns of biological targets in a sample |
| EP2818865A1 (en) | 2013-06-27 | 2014-12-31 | Alacris Theranostics GmbH | Method for the identification of effective drugs |
| US9898575B2 (en) | 2013-08-21 | 2018-02-20 | Seven Bridges Genomics Inc. | Methods and systems for aligning sequences |
| US9116866B2 (en) | 2013-08-21 | 2015-08-25 | Seven Bridges Genomics Inc. | Methods and systems for detecting sequence variants |
| EP3044329B1 (en) | 2013-09-13 | 2020-04-22 | Life Technologies Corporation | Device preparation using condensed nucleic acid particles |
| FR3011008B1 (fr) | 2013-09-24 | 2017-12-29 | Expanscience Lab | Procedes d'evaluation des effets deleteres des uv sur la peau d'enfant |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US10024851B2 (en) | 2013-10-15 | 2018-07-17 | International Business Machines Corporation | Use of disulfide bonds to form a reversible and reusable coating for nanofluidic devices |
| US9303310B2 (en) | 2013-10-15 | 2016-04-05 | International Business Machines Corporation | Nanofluidic sensor comprising spatially separated functional sensing components |
| US9255321B2 (en) | 2013-10-15 | 2016-02-09 | Globalfoundries Inc. | Directed surface functionalization on selected surface areas of topographical features with nanometer resolution |
| EP3058092B1 (en) | 2013-10-17 | 2019-05-22 | Illumina, Inc. | Methods and compositions for preparing nucleic acid libraries |
| WO2015058093A1 (en) * | 2013-10-18 | 2015-04-23 | Seven Bridges Genomics Inc. | Methods and systems for genotyping genetic samples |
| EP3058096A1 (en) | 2013-10-18 | 2016-08-24 | Good Start Genetics, Inc. | Methods for assessing a genomic region of a subject |
| WO2015058097A1 (en) | 2013-10-18 | 2015-04-23 | Seven Bridges Genomics Inc. | Methods and systems for identifying disease-induced mutations |
| WO2015058095A1 (en) | 2013-10-18 | 2015-04-23 | Seven Bridges Genomics Inc. | Methods and systems for quantifying sequence alignment |
| US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
| US11049587B2 (en) | 2013-10-18 | 2021-06-29 | Seven Bridges Genomics Inc. | Methods and systems for aligning sequences in the presence of repeating elements |
| US9092402B2 (en) | 2013-10-21 | 2015-07-28 | Seven Bridges Genomics Inc. | Systems and methods for using paired-end data in directed acyclic structure |
| DE102013221402A1 (de) * | 2013-10-22 | 2015-04-23 | Siemens Aktiengesellschaft | Verfahren zur Detektion und Quantifizierung von einer einzelsträngigen Ziel-Nukleinsäure |
| EP3068902B1 (en) | 2013-11-12 | 2018-08-29 | Life Technologies Corporation | System and method for emulsion breaking |
| AU2014364180B2 (en) | 2013-12-09 | 2021-03-04 | Illumina, Inc. | Methods and compositions for targeted nucleic acid sequencing |
| EP3792921A1 (en) | 2013-12-11 | 2021-03-17 | Genapsys, Inc. | Systems and methods for biological analysis and computation |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| WO2015089438A1 (en) | 2013-12-13 | 2015-06-18 | Northwestern University | Biomarkers for post-traumatic stress states |
| EP3083700B1 (en) | 2013-12-17 | 2023-10-11 | The Brigham and Women's Hospital, Inc. | Detection of an antibody against a pathogen |
| EP2886663A1 (en) | 2013-12-19 | 2015-06-24 | Centre National de la Recherche Scientifique (CNRS) | Nanopore sequencing using replicative polymerases and helicases |
| FR3016373B1 (fr) | 2014-01-10 | 2018-01-19 | Laboratoires Expanscience | Modele de peau de mammelon reconstitue |
| WO2015107430A2 (en) | 2014-01-16 | 2015-07-23 | Oslo Universitetssykehus Hf | Methods and biomarkers for detection and prognosis of cervical cancer |
| FR3019186B1 (fr) | 2014-03-31 | 2019-06-07 | Laboratoires Expanscience | Procedes d'evaluation des effets deleteres de l'urine sur la peau d'enfant |
| WO2015161054A2 (en) | 2014-04-18 | 2015-10-22 | Genapsys, Inc. | Methods and systems for nucleic acid amplification |
| US11053548B2 (en) | 2014-05-12 | 2021-07-06 | Good Start Genetics, Inc. | Methods for detecting aneuploidy |
| EP3151733B1 (en) | 2014-06-06 | 2020-04-15 | The Regents Of The University Of Michigan | Compositions and methods for characterizing and diagnosing periodontal disease |
| WO2015191877A1 (en) | 2014-06-11 | 2015-12-17 | Life Technologies Corporation | Systems and methods for substrate enrichment |
| CN114214314A (zh) | 2014-06-24 | 2022-03-22 | 生物辐射实验室股份有限公司 | 数字式pcr条码化 |
| US9921181B2 (en) | 2014-06-26 | 2018-03-20 | International Business Machines Corporation | Detection of translocation events using graphene-based nanopore assemblies |
| EP3594684A1 (en) | 2014-06-27 | 2020-01-15 | Abbott Laboratories | Compositions and methods for detecting human pegivirus 2 (hpgv-2) |
| EP3164505B1 (en) * | 2014-07-02 | 2018-06-27 | Life Technologies Corporation | Methods for loading a sensor substrate |
| WO2016007839A1 (en) | 2014-07-11 | 2016-01-14 | President And Fellows Of Harvard College | Methods for high-throughput labelling and detection of biological features in situ using microscopy |
| CN106715718B (zh) | 2014-07-24 | 2021-07-06 | 雅培分子公司 | 用于检测和分析结核分枝杆菌的组合物和方法 |
| US20160048608A1 (en) | 2014-08-15 | 2016-02-18 | Good Start Genetics, Inc. | Systems and methods for genetic analysis |
| WO2016040446A1 (en) | 2014-09-10 | 2016-03-17 | Good Start Genetics, Inc. | Methods for selectively suppressing non-target sequences |
| CA2999708A1 (en) | 2014-09-24 | 2016-03-31 | Good Start Genetics, Inc. | Process control for increased robustness of genetic assays |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| CN107002071A (zh) * | 2014-11-27 | 2017-08-01 | 株式会社日立高新技术 | 光点阵列基板、其制造方法、核酸聚合物解析方法以及装置 |
| US10066259B2 (en) | 2015-01-06 | 2018-09-04 | Good Start Genetics, Inc. | Screening for structural variants |
| AU2016220404B2 (en) | 2015-02-17 | 2021-05-27 | Mgi Tech Co., Ltd. | DNA sequencing using controlled strand displacement |
| WO2016134342A1 (en) | 2015-02-20 | 2016-08-25 | Wafergen, Inc. | Method for rapid accurate dispensing, visualization and analysis of single cells |
| CN107532124B (zh) | 2015-03-27 | 2022-08-09 | 精密科学公司 | 检测食管疾病 |
| EP4119677B1 (en) | 2015-04-10 | 2023-06-28 | Spatial Transcriptomics AB | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| US10275567B2 (en) | 2015-05-22 | 2019-04-30 | Seven Bridges Genomics Inc. | Systems and methods for haplotyping |
| US10344336B2 (en) | 2015-06-09 | 2019-07-09 | Life Technologies Corporation | Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging |
| US10526664B2 (en) | 2015-07-14 | 2020-01-07 | Abbott Molecular Inc. | Compositions and methods for identifying drug resistant tuberculosis |
| EP3322805B1 (en) | 2015-07-14 | 2021-10-20 | Abbott Molecular Inc. | Purification of nucleic acids using copper-titanium oxides or magnesium-titanium oxides |
| US10150994B2 (en) | 2015-07-22 | 2018-12-11 | Qiagen Waltham, Inc. | Modular flow cells and methods of sequencing |
| US10793895B2 (en) | 2015-08-24 | 2020-10-06 | Seven Bridges Genomics Inc. | Systems and methods for epigenetic analysis |
| US10724110B2 (en) | 2015-09-01 | 2020-07-28 | Seven Bridges Genomics Inc. | Systems and methods for analyzing viral nucleic acids |
| US10584380B2 (en) | 2015-09-01 | 2020-03-10 | Seven Bridges Genomics Inc. | Systems and methods for mitochondrial analysis |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| US9938572B1 (en) | 2015-09-08 | 2018-04-10 | Raindance Technologies, Inc. | System and method for forming an emulsion |
| BR112018006843A2 (en) | 2015-10-07 | 2018-12-11 | Selma Diagnostics Aps | flow system and methods for digital counting |
| US11347704B2 (en) | 2015-10-16 | 2022-05-31 | Seven Bridges Genomics Inc. | Biological graph or sequence serialization |
| CN108350485A (zh) | 2015-10-30 | 2018-07-31 | 精密科学发展有限责任公司 | 血浆dna的多重扩增检测测定以及分离和检测 |
| JP6882282B2 (ja) | 2015-11-03 | 2021-06-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 三次元核酸含有マトリックスの立体撮像のための方法と装置 |
| FR3045669B1 (fr) | 2015-12-16 | 2019-04-05 | Laboratoires Expanscience | Procedes d'evaluation des effets de la deshydratation sur la peau d'enfant |
| EP3400298B1 (en) | 2016-01-08 | 2024-03-06 | Bio-Rad Laboratories, Inc. | Multiple beads per droplet resolution |
| US10364468B2 (en) | 2016-01-13 | 2019-07-30 | Seven Bridges Genomics Inc. | Systems and methods for analyzing circulating tumor DNA |
| US10460829B2 (en) | 2016-01-26 | 2019-10-29 | Seven Bridges Genomics Inc. | Systems and methods for encoding genetic variation for a population |
| AU2017218431B2 (en) | 2016-02-08 | 2022-08-04 | RGENE, Inc. | Multiple ligase compositions, systems, and methods |
| US10262102B2 (en) | 2016-02-24 | 2019-04-16 | Seven Bridges Genomics Inc. | Systems and methods for genotyping with graph reference |
| WO2017160788A2 (en) | 2016-03-14 | 2017-09-21 | RGENE, Inc. | HYPER-THERMOSTABLE LYSINE-MUTANT ssDNA/RNA LIGASES |
| US10160987B2 (en) | 2016-04-07 | 2018-12-25 | Rebecca F. McClure | Composition and method for processing DNA |
| EP3440220B1 (en) * | 2016-04-07 | 2020-03-25 | Illumina, Inc. | Methods and systems for construction of normalized nucleic acid libraries |
| EP4613756A3 (en) | 2016-04-25 | 2025-11-12 | President And Fellows Of Harvard College | Hybridization chain reaction methods for in situ molecular detection |
| US11118233B2 (en) | 2016-05-18 | 2021-09-14 | The University Of Chicago | BTK mutation and ibrutinib resistance |
| WO2017222453A1 (en) | 2016-06-21 | 2017-12-28 | Hauling Thomas | Nucleic acid sequencing |
| FR3053053B1 (fr) | 2016-06-23 | 2018-07-13 | Laboratoires Expanscience | Modeles de la dermatite atopique juvenile |
| CN109476695A (zh) | 2016-06-27 | 2019-03-15 | 丹娜法伯癌症研究院 | 用于测定rna翻译速率的方法 |
| US11091795B2 (en) | 2016-07-11 | 2021-08-17 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for diagnosing and treating arrhythmias |
| CN109790575A (zh) | 2016-07-20 | 2019-05-21 | 吉纳普赛斯股份有限公司 | 用于核酸测序的系统和方法 |
| CN109070044B (zh) | 2016-07-21 | 2021-07-30 | 宝生物工程(美国)有限公司 | 使用多孔装置进行的多z平面成像和分配 |
| JP6925051B2 (ja) | 2016-07-29 | 2021-08-25 | セルマ・ダイアグノスティクス・アンパルトセルスカブSelma Diagnostics Aps | デジタル計数のための方法の改良 |
| EP3507364A4 (en) | 2016-08-31 | 2020-05-20 | President and Fellows of Harvard College | METHODS OF GENERATING NUCLEIC ACID SEQUENCE LIBRARIES FOR IN SITU FLUORESCENT SEQUENCING DETECTION |
| CN109923216B (zh) | 2016-08-31 | 2024-08-02 | 哈佛学院董事及会员团体 | 将生物分子的检测组合到使用荧光原位测序的单个试验的方法 |
| US11250931B2 (en) | 2016-09-01 | 2022-02-15 | Seven Bridges Genomics Inc. | Systems and methods for detecting recombination |
| JP6730525B2 (ja) * | 2016-11-21 | 2020-07-29 | ナノストリング テクノロジーズ,インコーポレイティド | 化学組成物とそれを利用する方法 |
| FR3059550B1 (fr) | 2016-12-01 | 2020-01-03 | Universite De Rouen Normandie | Traitement des troubles causes par l'alcoolisation foetale (tcaf) |
| CN110139932B (zh) | 2016-12-19 | 2024-05-17 | 生物辐射实验室股份有限公司 | 液滴加标的相邻性保留的标签化dna |
| GB201700983D0 (en) | 2017-01-20 | 2017-03-08 | Life Tech As | Polymeric particles |
| CN110475875B (zh) | 2017-01-27 | 2024-06-25 | 精密科学公司 | 通过分析甲基化dna检测结肠瘤形成 |
| US11091791B2 (en) | 2017-02-24 | 2021-08-17 | Mgi Tech Co., Ltd. | Methods for hybridization based hook ligation |
| CN108373971A (zh) * | 2017-03-11 | 2018-08-07 | 南京科维思生物科技股份有限公司 | 用于进行实时数字pcr的方法和装置 |
| AU2018279728B2 (en) | 2017-06-08 | 2023-07-20 | The Brigham And Women's Hospital, Inc. | Methods and compositions for identifying epitopes |
| US11542540B2 (en) | 2017-06-16 | 2023-01-03 | Life Technologies Corporation | Control nucleic acids, and compositions, kits, and uses thereof |
| US11186862B2 (en) | 2017-06-20 | 2021-11-30 | Bio-Rad Laboratories, Inc. | MDA using bead oligonucleotide |
| JP7066756B2 (ja) * | 2017-06-21 | 2022-05-13 | ライトキャスト ディスカバリー リミテッド | 核酸等の分子を調査するための方法 |
| FR3068045B1 (fr) | 2017-06-22 | 2021-06-04 | Expanscience Lab | Modeles de peau sensible reconstituee |
| WO2019018561A1 (en) * | 2017-07-19 | 2019-01-24 | The Scripps Research Institute | GENOMIC LIBRARY GENERATION IN SOLID PHASE FOR HIGH FLOW SEQUENCING |
| PT3663407T (pt) | 2017-08-01 | 2023-03-27 | Complete Genomics Inc | Método de sequenciamento de ácidos nucleicos |
| SK862017A3 (sk) | 2017-08-24 | 2020-05-04 | Grendar Marian Doc Mgr Phd | Spôsob použitia fetálnej frakcie a chromozómovej reprezentácie pri určovaní aneuploidného stavu v neinvazívnom prenatálnom testovaní |
| US11993813B2 (en) * | 2017-08-31 | 2024-05-28 | Mgi Tech Co., Ltd. | Nucleic acid probe and nucleic acid sequencing method |
| JP2020532999A (ja) | 2017-09-07 | 2020-11-19 | クーパーゲノミクス, インコーポレイテッド | 非侵襲性の移植前遺伝子診断のためのシステムおよび方法 |
| WO2019074615A2 (en) | 2017-09-14 | 2019-04-18 | OneSkin Technologies, Inc. | IN VITRO METHODS FOR DISCOVERING THERAPEUTIC COMPOUNDS FOR THE SKIN USING SKIN AGING BIOMARKERS |
| EP3684951A4 (en) | 2017-09-21 | 2021-06-16 | Genapsys, Inc. | NUCLEIC ACID SEQUENCING SYSTEMS AND METHODS |
| WO2019067635A1 (en) | 2017-09-27 | 2019-04-04 | Ultima Genomics, Inc. | METHODS AND SYSTEMS FOR NUCLEIC ACID SEQUENCING |
| CN111787930B (zh) | 2017-10-06 | 2024-12-20 | 芝加哥大学 | 针对癌症特异性抗原对t淋巴细胞的筛选 |
| CN120210336A (zh) | 2017-10-06 | 2025-06-27 | 10X基因组学有限公司 | Rna模板化连接 |
| CN118186055A (zh) | 2017-11-02 | 2024-06-14 | 生物辐射实验室股份有限公司 | 基于转座酶的基因组分析 |
| MX389484B (es) | 2017-11-13 | 2025-03-20 | The Multiple Myeloma Res Foundation Inc | Base de datos, de datos moleculares, omicos, de inmunoterapia, metabolicos, epigeneticos y clinicos, integrados |
| AU2018372906B2 (en) | 2017-11-22 | 2025-04-03 | The Regents Of The University Of Michigan | Compositions and methods for treating cancer |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| US11701656B2 (en) | 2018-01-02 | 2023-07-18 | The Regents Of The University Of Michigan | Multi-droplet capture |
| EP4324962A3 (en) | 2018-01-31 | 2024-05-08 | Bio-Rad Laboratories, Inc. | Methods and compositions for deconvoluting partition barcodes |
| WO2019200214A1 (en) | 2018-04-13 | 2019-10-17 | The Regents Of The University Of Michigan | Compositions and methods for treating cancer |
| JP7347849B2 (ja) | 2018-04-19 | 2023-09-20 | ファースト ライト ダイアグノスティクス, インコーポレイテッド | 標的の検出 |
| WO2019213619A1 (en) | 2018-05-04 | 2019-11-07 | Abbott Laboratories | Hbv diagnostic, prognostic, and therapeutic methods and products |
| EP3794146B1 (en) | 2018-05-14 | 2025-12-10 | Bruker Spatial Biology, Inc. | Method for identifying a predetermined nucleotide sequence |
| FR3081707A1 (fr) | 2018-05-30 | 2019-12-06 | Universite De Rouen Normandie | Traitement des troubles neurologiques causes par l'alcoolisation foetale |
| US11093547B2 (en) | 2018-06-19 | 2021-08-17 | Intel Corporation | Data storage based on encoded DNA sequences |
| KR102163563B1 (ko) | 2018-06-26 | 2020-10-08 | 국민대학교산학협력단 | 자외선을 이용한 생체적합성 폴리감마글루탐산 하이드로젤 제조방법 |
| CN118994395A (zh) | 2018-07-20 | 2024-11-22 | 皮埃尔法布雷医药公司 | Vista受体 |
| CN112770776B (zh) | 2018-07-30 | 2025-08-19 | 瑞德库尔有限责任公司 | 用于样品处理或分析的方法和系统 |
| US11479816B2 (en) | 2018-08-20 | 2022-10-25 | Bio-Rad Laboratories, Inc. | Nucleotide sequence generation by barcode bead-colocalization in partitions |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| WO2020056389A1 (en) | 2018-09-13 | 2020-03-19 | Human Longevity, Inc. | Multimodal signatures and use thereof in the diagnosis and prognosis of diseases |
| CA3115289A1 (en) | 2018-10-04 | 2020-04-09 | First Light Diagnostics, Inc. | Test cartridges |
| AU2019356033A1 (en) | 2018-10-05 | 2021-05-27 | Coopersurgical, Inc. | Systems and methods for identifying chromosomal abnormalities in an embryo |
| WO2020076976A1 (en) | 2018-10-10 | 2020-04-16 | Readcoor, Inc. | Three-dimensional spatial molecular indexing |
| AU2019356597A1 (en) | 2018-10-12 | 2021-05-20 | Human Longevity, Inc. | Multi-omic search engine for integrative analysis of cancer genomic and clinical data |
| US12139764B2 (en) | 2018-11-14 | 2024-11-12 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Systems and methods for characterizing and treating breast cancer |
| IL311084A (en) | 2018-11-30 | 2024-04-01 | Caris Mpi Inc | New generation molecular characterization |
| US12385083B2 (en) | 2018-12-10 | 2025-08-12 | 10X Genomics, Inc. | Methods of using master / copy arrays for spatial detection |
| FR3091351B1 (fr) | 2018-12-27 | 2021-05-21 | Univ Rouen Centre Hospitalier | Biomarqueur de la maladie de fabry |
| US20220081714A1 (en) | 2019-01-04 | 2022-03-17 | Northwestern University | Storing temporal data into dna |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| WO2020169635A1 (en) | 2019-02-20 | 2020-08-27 | Grendar Marian | Method for determining the uncertainty of the degree of placental mosaicism of a sample in non-invasive prenatal screening |
| US11281856B2 (en) | 2019-05-24 | 2022-03-22 | Gnx Data Systems Ltd. | Systems and methods for using dynamic reference graphs to accurately align sequence reads |
| EP3976820A1 (en) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| CN113906147B (zh) | 2019-05-31 | 2024-09-13 | 10X基因组学有限公司 | 检测目标核酸分子的方法 |
| CN114402392A (zh) | 2019-06-21 | 2022-04-26 | 酷博尔外科器械有限公司 | 使用单核苷酸变异密度验证人类胚胎中拷贝数变异的系统和方法 |
| CN114258572A (zh) | 2019-06-21 | 2022-03-29 | 酷博尔外科器械有限公司 | 用于确定基因组倍性的系统和方法 |
| JP7333838B2 (ja) | 2019-06-21 | 2023-08-25 | クーパーサージカル・インコーポレイテッド | 胚における遺伝パターンを決定するためのシステム、コンピュータプログラム及び方法 |
| FR3098405B1 (fr) | 2019-07-12 | 2021-06-25 | Expanscience Lab | Composition comprenant des polyphénols de graines de passiflore, des peptides d’avocat et un extrait d’hamamélis et utilisation pour traiter et/ou prévenir les vergetures |
| TWI862641B (zh) | 2019-07-22 | 2024-11-21 | 美商第一美膚公司 | 具有抗老化功效之多肽及其用途 |
| US11287422B2 (en) | 2019-09-23 | 2022-03-29 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
| EP4025711A2 (en) | 2019-11-08 | 2022-07-13 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
| WO2021112918A1 (en) | 2019-12-02 | 2021-06-10 | Caris Mpi, Inc. | Pan-cancer platinum response predictor |
| GB201919032D0 (en) | 2019-12-20 | 2020-02-05 | Cartana Ab | Method of detecting an analyte |
| WO2021133849A1 (en) | 2019-12-23 | 2021-07-01 | 10X Genomics, Inc. | Methods for spatial analysis using rna-templated ligation |
| IL289295B2 (en) * | 2019-12-23 | 2025-07-01 | Illumina Cambridge Ltd | A nanoparticle with a single site for attaching a polynucleotide template |
| WO2021133842A1 (en) | 2019-12-23 | 2021-07-01 | 10X Genomics, Inc. | Compositions and methods for using fixed biological samples in partition-based assays |
| US12365942B2 (en) | 2020-01-13 | 2025-07-22 | 10X Genomics, Inc. | Methods of decreasing background on a spatial array |
| US12405264B2 (en) | 2020-01-17 | 2025-09-02 | 10X Genomics, Inc. | Electrophoretic system and method for analyte capture |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US20210230681A1 (en) | 2020-01-24 | 2021-07-29 | 10X Genomics, Inc. | Methods for spatial analysis using proximity ligation |
| WO2021152586A1 (en) | 2020-01-30 | 2021-08-05 | Yeda Research And Development Co. Ltd. | Methods of analyzing microbiome, immunoglobulin profile and physiological state |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US12110548B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Bi-directional in situ analysis |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| US12129516B2 (en) | 2020-02-07 | 2024-10-29 | 10X Genomics, Inc. | Quantitative and automated permeabilization performance evaluation for spatial transcriptomics |
| IL294909A (en) | 2020-02-13 | 2022-09-01 | Zymergen Inc | Metagenomic library and natural product discovery platform |
| US12281357B1 (en) | 2020-02-14 | 2025-04-22 | 10X Genomics, Inc. | In situ spatial barcoding |
| US12215379B2 (en) | 2020-02-17 | 2025-02-04 | 10X Genomics, Inc. | In situ analysis of chromatin interaction |
| JP2023514749A (ja) | 2020-02-21 | 2023-04-07 | 10エックス ジェノミクス インコーポレイテッド | 統合型インサイチュ空間的アッセイのための方法および組成物 |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| US12188085B2 (en) | 2020-03-05 | 2025-01-07 | 10X Genomics, Inc. | Three-dimensional spatial transcriptomics with sequencing readout |
| WO2021214766A1 (en) | 2020-04-21 | 2021-10-28 | Yeda Research And Development Co. Ltd. | Methods of diagnosing viral infections and vaccines thereto |
| EP4549582A3 (en) | 2020-04-22 | 2025-06-18 | 10x Genomics, Inc. | Methods for spatial analysis using targeted rna depletion |
| WO2021224677A1 (en) | 2020-05-05 | 2021-11-11 | Akershus Universitetssykehus Hf | Compositions and methods for characterizing bowel cancer |
| CN115916967A (zh) | 2020-05-12 | 2023-04-04 | 伊鲁米纳公司 | 使用重组末端脱氧核苷酸转移酶生成具有经修饰的碱基的核酸 |
| WO2021236929A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
| EP4553168A3 (en) | 2020-05-22 | 2025-08-27 | 10x Genomics, Inc. | Spatial analysis to detect sequence variants |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| US20230193356A1 (en) | 2020-06-08 | 2023-06-22 | The Broad Institute, Inc. | Single cell combinatorial indexing from amplified nucleic acids |
| ES2981265T3 (es) | 2020-06-08 | 2024-10-08 | 10X Genomics Inc | Métodos para determinar un margen quirúrgico y métodos de uso del mismo |
| EP3922641A1 (en) | 2020-06-09 | 2021-12-15 | Institut Gustave-Roussy | Methods for detecting and treating covid patients requiring intensive care |
| US12209273B2 (en) | 2020-06-12 | 2025-01-28 | 10X Genomics, Inc. | Nucleic acid assays using click chemistry bioconjugation |
| EP4450639B1 (en) | 2020-06-25 | 2025-10-15 | 10X Genomics, Inc. | Spatial analysis of dna methylation |
| EP4176437A1 (en) | 2020-07-02 | 2023-05-10 | 10X Genomics, Inc. | Systems and methods for detection of low-abundance molecular barcodes from a sequencing library |
| EP4176436A1 (en) | 2020-07-02 | 2023-05-10 | 10X Genomics, Inc. | Systems and methods for detecting cell-associated barcodes from single-cell partitions |
| US12209280B1 (en) | 2020-07-06 | 2025-01-28 | 10X Genomics, Inc. | Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis |
| US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
| US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
| WO2022020728A1 (en) | 2020-07-23 | 2022-01-27 | 10X Genomics, Inc. | Systems and methods for detecting and removing aggregates for calling cell-associated barcodes |
| US12116637B2 (en) | 2020-07-24 | 2024-10-15 | The Regents Of The University Of Michigan | Compositions and methods for detecting and treating high grade subtypes of uterine cancer |
| EP4185870A1 (en) | 2020-07-24 | 2023-05-31 | Genentech, Inc. | Determining hemodilution of bone marrow aspirates using biomarkers |
| US12297499B2 (en) | 2020-08-17 | 2025-05-13 | 10X Genomics, Inc. | Multicomponent nucleic acid probes for sample analysis |
| US20220049303A1 (en) | 2020-08-17 | 2022-02-17 | Readcoor, Llc | Methods and systems for spatial mapping of genetic variants |
| US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
| US12469162B2 (en) | 2020-08-31 | 2025-11-11 | Element Biosciences, Inc. | Primary analysis in next generation sequencing |
| US11200446B1 (en) | 2020-08-31 | 2021-12-14 | Element Biosciences, Inc. | Single-pass primary analysis |
| EP4182926A4 (en) | 2020-09-04 | 2024-01-03 | 10X Genomics, Inc. | Systems and methods for identifying feature linkages in multi-genomic feature data from single-cell partitions |
| US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| EP4442838A3 (en) | 2020-10-15 | 2024-12-25 | Genentech, Inc. | Multiplexed target-binding candidate screening analysis |
| US12071667B2 (en) | 2020-11-04 | 2024-08-27 | 10X Genomics, Inc. | Sequence analysis using meta-stable nucleic acid molecules |
| US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
| EP4121555A1 (en) | 2020-12-21 | 2023-01-25 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| US12060603B2 (en) | 2021-01-19 | 2024-08-13 | 10X Genomics, Inc. | Methods for internally controlled in situ assays using padlock probes |
| WO2022174054A1 (en) | 2021-02-13 | 2022-08-18 | The General Hospital Corporation | Methods and compositions for in situ macromolecule detection and uses thereof |
| US12275984B2 (en) | 2021-03-02 | 2025-04-15 | 10X Genomics, Inc. | Sequential hybridization and quenching |
| WO2022221425A1 (en) | 2021-04-14 | 2022-10-20 | 10X Genomics, Inc. | Methods of measuring mislocalization of an analyte |
| WO2022236054A1 (en) | 2021-05-06 | 2022-11-10 | 10X Genomics, Inc. | Methods for increasing resolution of spatial analysis |
| US12376589B2 (en) | 2021-05-14 | 2025-08-05 | Pluton Biosciences, Inc. | Chryseobacterium insect inhibitory microbial compositions and methods of making and using |
| EP4582555A3 (en) | 2021-06-03 | 2025-10-22 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
| US11859241B2 (en) | 2021-06-17 | 2024-01-02 | Element Biosciences, Inc. | Compositions and methods for pairwise sequencing |
| US11236388B1 (en) | 2021-06-17 | 2022-02-01 | Element Biosciences, Inc. | Compositions and methods for pairwise sequencing |
| IL309440A (en) | 2021-06-18 | 2024-02-01 | Element Biosciences Inc | Engineered polymerases |
| US20240287594A1 (en) | 2021-06-30 | 2024-08-29 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for enrichment of nucleic acids using light-mediated cross-linking |
| WO2023009842A1 (en) | 2021-07-30 | 2023-02-02 | 10X Genomics, Inc. | Methods and compositions for synchronizing reactions in situ |
| US12139751B2 (en) | 2021-07-30 | 2024-11-12 | 10X Genomics, Inc. | Circularizable probes for in situ analysis |
| US12391984B2 (en) | 2021-08-03 | 2025-08-19 | 10X Genomics, Inc. | Compositions and methods for rolling circle amplification |
| US12460251B2 (en) | 2021-08-03 | 2025-11-04 | 10X Genomics, Inc. | Stabilization and/or compaction of nucleic acid molecules |
| CN117858958A (zh) | 2021-08-16 | 2024-04-09 | 10X基因组学有限公司 | 包含分割条形码区的探针和使用方法 |
| EP4196605B1 (en) | 2021-09-01 | 2024-12-04 | 10X Genomics, Inc. | Methods for blocking a capture probe on a spatial array |
| EP4419707A1 (en) | 2021-11-10 | 2024-08-28 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of an analyte in a biological sample |
| WO2023102118A2 (en) | 2021-12-01 | 2023-06-08 | 10X Genomics, Inc. | Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis |
| US20240263229A1 (en) | 2021-12-16 | 2024-08-08 | Illumina, Inc. | Hybrid clustering |
| CN116266129A (zh) * | 2021-12-17 | 2023-06-20 | 戴尔产品有限公司 | 分布式计算系统中的多领导者选举 |
| EP4463568A1 (en) | 2022-01-13 | 2024-11-20 | Oslo Universitetssykehus HF | Prostate cancer markers and uses thereof |
| WO2023152568A2 (en) | 2022-02-10 | 2023-08-17 | Oslo Universitetssykehus Hf | Compositions and methods for characterizing lung cancer |
| FR3133198B1 (fr) | 2022-03-04 | 2025-11-21 | Pierre Fabre Dermo Cosmetique | Modele de peau reconstituee |
| CN118974836A (zh) | 2022-03-08 | 2024-11-15 | 10X基因组学有限公司 | 将光学拥挤最小化的原位代码设计方法 |
| WO2023175037A2 (en) | 2022-03-15 | 2023-09-21 | Illumina, Inc. | Concurrent sequencing of forward and reverse complement strands on separate polynucleotides for methylation detection |
| EP4493721A1 (en) | 2022-03-15 | 2025-01-22 | Illumina, Inc. | Parallel sample and index sequencing |
| US20230348973A1 (en) | 2022-03-31 | 2023-11-02 | Illumina Cambridge Limited | Paired-end re-synthesis using blocked p5 primers |
| EP4505177A1 (en) | 2022-04-01 | 2025-02-12 | 10x Genomics, Inc. | Compositions and methods for targeted masking of autofluorescence |
| CN119213143A (zh) | 2022-05-11 | 2024-12-27 | 10X基因组学有限公司 | 用于原位测序的组合物和方法 |
| WO2023245190A1 (en) | 2022-06-17 | 2023-12-21 | 10X Genomics, Inc. | Catalytic de-crosslinking of samples for in situ analysis |
| WO2024040060A1 (en) | 2022-08-16 | 2024-02-22 | 10X Genomics, Inc. | Ap50 polymerases and uses thereof |
| EP4590854A1 (en) | 2022-09-19 | 2025-07-30 | Illumina, Inc. | Deformable polymers comprising immobilised primers |
| US20240102067A1 (en) | 2022-09-26 | 2024-03-28 | Illumina, Inc. | Resynthesis Kits and Methods |
| US20240124929A1 (en) | 2022-09-30 | 2024-04-18 | Illumina, Inc. | Mesophilic compositions for nucleic acid amplification |
| US20240124914A1 (en) | 2022-09-30 | 2024-04-18 | Illumina, Inc. | Thermophilic compositions for nucleic acid amplification |
| US20240110234A1 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Amplification Compositions and Methods |
| US20240110221A1 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Methods of modulating clustering kinetics |
| WO2024098046A1 (en) | 2022-11-04 | 2024-05-10 | 10X Genomics, Inc. | Systems and methods for determining antigen specificity of antigen binding molecules and visualizing adaptive immune cell clonotyping data |
| WO2024123917A1 (en) | 2022-12-07 | 2024-06-13 | Illumina, Inc. | Monoclonal clustering using double stranded dna size exclusion with patterned seeding |
| WO2024129672A1 (en) | 2022-12-12 | 2024-06-20 | The Broad Institute, Inc. | Trafficked rnas for assessment of cell-cell connectivity and neuroanatomy |
| WO2024256580A1 (en) | 2023-06-14 | 2024-12-19 | Illumina, Inc. | Concurrent sequencing with spatially separated rings |
| WO2025024672A1 (en) | 2023-07-26 | 2025-01-30 | Element Biosciences, Inc. | Dna sequencing systems and use thereof |
| US12319956B2 (en) | 2023-07-31 | 2025-06-03 | 10X Genomics, Inc. | Methods and systems for targeted RNA cleavage and target RNA-primed rolling circle amplification |
| WO2025062341A1 (en) | 2023-09-20 | 2025-03-27 | Element Biosciences, Inc. | Solid-state and configurable optical test targets and flow cell devices |
| WO2025062001A1 (en) | 2023-09-20 | 2025-03-27 | Illumina, Inc. | Optimised nucleic acid sequencing |
| WO2025104619A1 (en) | 2023-11-13 | 2025-05-22 | Oslo Universitetssykehus Hf | Breast cancer markers and uses thereof |
| WO2025137479A1 (en) | 2023-12-22 | 2025-06-26 | Illumina, Inc. | Reusable flow cells and methods of using them for nucleic acid sequencing |
| WO2025196650A1 (en) | 2024-03-19 | 2025-09-25 | Element Biosciences, Inc. | Flow cell devices and use thereof |
| WO2025196731A1 (en) | 2024-03-22 | 2025-09-25 | Element Biosciences, Inc. | Polymeric multivalent conjugates and related uses |
| WO2025196727A1 (en) | 2024-03-22 | 2025-09-25 | Element Biosciences, Inc. | Macromolecular multivalent conjugates and related uses |
| WO2025235016A1 (en) | 2024-05-07 | 2025-11-13 | Element Biosciences, Inc. | Sequencing method with spatial flexibility |
Family Cites Families (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US836A (en) | 1838-07-12 | Augustus a | ||
| US6309A (en) | 1849-04-10 | Planing-machine | ||
| US5118605A (en) | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
| US5430136A (en) | 1984-10-16 | 1995-07-04 | Chiron Corporation | Oligonucleotides having selectably cleavable and/or abasic sites |
| US4883750A (en) | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4863849A (en) | 1985-07-18 | 1989-09-05 | New York Medical College | Automatable process for sequencing nucleotide |
| US4613163A (en) | 1985-11-04 | 1986-09-23 | The Dow Chemical Company | Joint for pipe |
| US5011769A (en) | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
| US4855225A (en) | 1986-02-07 | 1989-08-08 | Applied Biosystems, Inc. | Method of detecting electrophoretically separated oligonucleotides |
| US4888750A (en) * | 1986-03-07 | 1989-12-19 | Kryder Mark H | Method and system for erase before write magneto-optic recording |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| DE68916671T2 (de) | 1988-03-18 | 1995-03-02 | Baylor College Medicine | Mutationsnachweis durch kompetitiven Oligonukleotid-Priming. |
| US4988617A (en) * | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
| US5002867A (en) | 1988-04-25 | 1991-03-26 | Macevicz Stephen C | Nucleic acid sequence determination by multiple mixed oligonucleotide probes |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
| CA2025645C (en) | 1989-09-19 | 1999-01-19 | Keiji Fukuda | Control channel terminating interface and its testing device for sending and receiving signal |
| GB2236852B (en) | 1989-09-25 | 1994-04-06 | Scotgen Ltd | DNA probe based assays and intermediates useful in the synthesis of cleavable nucleic acids for use in such assays |
| US5366860A (en) | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
| WO1991006678A1 (en) | 1989-10-26 | 1991-05-16 | Sri International | Dna sequencing |
| US5188934A (en) | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
| YU187991A (sh) * | 1990-12-11 | 1994-09-09 | Hoechst Aktiengesellschaft | 3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba |
| US5627032A (en) | 1990-12-24 | 1997-05-06 | Ulanovsky; Levy | Composite primers for nucleic acids |
| DK0597960T3 (da) | 1991-08-10 | 1999-09-13 | Medical Res Council | Behandling af cellepopulationer |
| CA2077135A1 (en) | 1991-08-30 | 1993-03-01 | Joh-E Ikeda | A method of dna amplification |
| GB9208733D0 (en) * | 1992-04-22 | 1992-06-10 | Medical Res Council | Dna sequencing method |
| US5403708A (en) * | 1992-07-06 | 1995-04-04 | Brennan; Thomas M. | Methods and compositions for determining the sequence of nucleic acids |
| US5795714A (en) | 1992-11-06 | 1998-08-18 | Trustees Of Boston University | Method for replicating an array of nucleic acid probes |
| US5503980A (en) * | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
| FR2703052B1 (fr) * | 1993-03-26 | 1995-06-02 | Pasteur Institut | Nouvelle méthode de séquençage d'acides nucléiques. |
| JP3373632B2 (ja) * | 1993-03-31 | 2003-02-04 | 株式会社東芝 | 不揮発性半導体記憶装置 |
| EP0696775A1 (en) | 1993-04-21 | 1996-02-14 | Hitachi, Ltd. | Computer-aided design and production system for component arrangement and pipe routing |
| GB9315847D0 (en) | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| US6007987A (en) * | 1993-08-23 | 1999-12-28 | The Trustees Of Boston University | Positional sequencing by hybridization |
| ATE257861T1 (de) | 1993-09-27 | 2004-01-15 | Arch Dev Corp | Methoden und zusammensetzungen zur effizienten nukleinsaeuresequenzierung |
| US6401267B1 (en) * | 1993-09-27 | 2002-06-11 | Radoje Drmanac | Methods and compositions for efficient nucleic acid sequencing |
| GB9401200D0 (en) | 1994-01-21 | 1994-03-16 | Medical Res Council | Sequencing of nucleic acids |
| US5552278A (en) | 1994-04-04 | 1996-09-03 | Spectragen, Inc. | DNA sequencing by stepwise ligation and cleavage |
| US5714330A (en) | 1994-04-04 | 1998-02-03 | Lynx Therapeutics, Inc. | DNA sequencing by stepwise ligation and cleavage |
| US5641658A (en) | 1994-08-03 | 1997-06-24 | Mosaic Technologies, Inc. | Method for performing amplification of nucleic acid with two primers bound to a single solid support |
| US5705628A (en) | 1994-09-20 | 1998-01-06 | Whitehead Institute For Biomedical Research | DNA purification and isolation using magnetic particles |
| US5695934A (en) * | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
| US6654505B2 (en) | 1994-10-13 | 2003-11-25 | Lynx Therapeutics, Inc. | System and apparatus for sequential processing of analytes |
| US6406848B1 (en) | 1997-05-23 | 2002-06-18 | Lynx Therapeutics, Inc. | Planar arrays of microparticle-bound polynucleotides |
| US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
| US5846719A (en) * | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
| US6013445A (en) * | 1996-06-06 | 2000-01-11 | Lynx Therapeutics, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
| SE9500342D0 (sv) | 1995-01-31 | 1995-01-31 | Marek Kwiatkowski | Novel chain terminators, the use thereof for nucleic acid sequencing and synthesis and a method of their preparation |
| US5750341A (en) * | 1995-04-17 | 1998-05-12 | Lynx Therapeutics, Inc. | DNA sequencing by parallel oligonucleotide extensions |
| DE19527155C2 (de) * | 1995-07-25 | 1998-12-10 | Deutsches Krebsforsch | Verfahren zur Sequenzierung durch Oligomerhybridisierung |
| JP3974941B2 (ja) | 1995-11-21 | 2007-09-12 | イェール ユニバーシティ | 単分子セグメントの増幅および検出 |
| US6090549A (en) * | 1996-01-16 | 2000-07-18 | University Of Chicago | Use of continuous/contiguous stacking hybridization as a diagnostic tool |
| PL331513A1 (en) | 1996-06-06 | 1999-07-19 | Lynx Therapeutics | Method of sequencing, by a ligand effect, specific encoded adapters and composition containing double-string oligonucleotidic adapters |
| GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
| GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
| US7094531B1 (en) | 1997-01-15 | 2006-08-22 | Xzillion Gmbh Co. | Nucleic acid sequencing |
| US20020042048A1 (en) * | 1997-01-16 | 2002-04-11 | Radoje Drmanac | Methods and compositions for detection or quantification of nucleic acid species |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| US6023540A (en) | 1997-03-14 | 2000-02-08 | Trustees Of Tufts College | Fiber optic sensor with encoded microspheres |
| US5888737A (en) * | 1997-04-15 | 1999-03-30 | Lynx Therapeutics, Inc. | Adaptor-based sequence analysis |
| US6406845B1 (en) | 1997-05-05 | 2002-06-18 | Trustees Of Tuft College | Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample |
| DK1801214T3 (da) | 1997-07-07 | 2011-01-24 | Medical Res Council | In vitro sorteringsfremgangsmåde |
| US6511803B1 (en) | 1997-10-10 | 2003-01-28 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
| US6235480B1 (en) * | 1998-03-13 | 2001-05-22 | Promega Corporation | Detection of nucleic acid hybrids |
| US6534262B1 (en) | 1998-05-14 | 2003-03-18 | Whitehead Institute For Biomedical Research | Solid phase technique for selectively isolating nucleic acids |
| AU4194899A (en) | 1998-05-21 | 1999-12-06 | Hyseq, Inc. | Linear arrays of immobilized compounds and methods of using same |
| US6306643B1 (en) | 1998-08-24 | 2001-10-23 | Affymetrix, Inc. | Methods of using an array of pooled probes in genetic analysis |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US6429027B1 (en) | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
| US7510841B2 (en) | 1998-12-28 | 2009-03-31 | Illumina, Inc. | Methods of making and using composite arrays for the detection of a plurality of target analytes |
| GB9900298D0 (en) | 1999-01-07 | 1999-02-24 | Medical Res Council | Optical sorting method |
| US6632655B1 (en) | 1999-02-23 | 2003-10-14 | Caliper Technologies Corp. | Manipulation of microparticles in microfluidic systems |
| JP2003527075A (ja) | 1999-03-25 | 2003-09-16 | ハイセック,インコーポレーテッド | ハイブリダイゼーションによる配列分析のための、溶液ベースの方法 |
| US6355431B1 (en) * | 1999-04-20 | 2002-03-12 | Illumina, Inc. | Detection of nucleic acid amplification reactions using bead arrays |
| US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US6309836B1 (en) | 1999-10-05 | 2001-10-30 | Marek Kwiatkowski | Compounds for protecting hydroxyls and methods for their use |
| US7041445B2 (en) | 1999-11-15 | 2006-05-09 | Clontech Laboratories, Inc. | Long oligonucleotide arrays |
| CA2393658A1 (en) | 1999-12-23 | 2001-06-28 | Illumina, Inc. | Decoding of array sensors with microspheres |
| JP3499795B2 (ja) * | 2000-01-31 | 2004-02-23 | 浜松ホトニクス株式会社 | 遺伝子解析法 |
| US6664079B2 (en) | 2000-10-06 | 2003-12-16 | The Trustees Of Columbia University In The City Of New York | Massive parallel method for decoding DNA and RNA |
| US6844028B2 (en) | 2001-06-26 | 2005-01-18 | Accelr8 Technology Corporation | Functional surface coating |
| US20030068609A1 (en) * | 2001-08-29 | 2003-04-10 | Krishan Chari | Random array of microspheres |
| US6744028B2 (en) * | 2001-10-29 | 2004-06-01 | Mars Incorporated | Semi-rigid hand-held food package |
| US20030087298A1 (en) | 2001-11-02 | 2003-05-08 | Roland Green | Detection of hybridization on oligonucleotide microarray through covalently labeling microarray probe |
| GB0127564D0 (en) | 2001-11-16 | 2002-01-09 | Medical Res Council | Emulsion compositions |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| US7037659B2 (en) | 2002-01-31 | 2006-05-02 | Nimblegen Systems Inc. | Apparatus for constructing DNA probes having a prismatic and kaleidoscopic light homogenizer |
| US7108891B2 (en) * | 2002-03-07 | 2006-09-19 | Eastman Kodak Company | Random array of microspheres |
| US7011971B2 (en) * | 2002-06-03 | 2006-03-14 | Eastman Kodak Company | Method of making random array of microspheres using enzyme digestion |
| SI3363809T1 (sl) | 2002-08-23 | 2020-08-31 | Illumina Cambridge Limited | Modificirani nukleotidi za polinukleotidno sekvenciranje |
| EP1556506A1 (en) | 2002-09-19 | 2005-07-27 | The Chancellor, Masters And Scholars Of The University Of Oxford | Molecular arrays and single molecule detection |
| US7498176B2 (en) | 2002-09-27 | 2009-03-03 | Roche Nimblegen, Inc. | Microarray with hydrophobic barriers |
| CA2513535C (en) | 2003-01-29 | 2012-06-12 | 454 Corporation | Bead emulsion nucleic acid amplification |
| WO2005010145A2 (en) | 2003-07-05 | 2005-02-03 | The Johns Hopkins University | Method and compositions for detection and enumeration of genetic variations |
| US20050019745A1 (en) * | 2003-07-23 | 2005-01-27 | Eastman Kodak Company | Random array of microspheres |
| GB0320059D0 (en) | 2003-08-27 | 2003-10-01 | Solexa Ltd | A method of sequencing |
| GB0324456D0 (en) * | 2003-10-20 | 2003-11-19 | Isis Innovation | Parallel DNA sequencing methods |
| US20060024681A1 (en) | 2003-10-31 | 2006-02-02 | Agencourt Bioscience Corporation | Methods for producing a paired tag from a nucleic acid sequence and methods of use thereof |
| DE602005020421D1 (de) * | 2004-02-19 | 2010-05-20 | Helicos Biosciences Corp | Verfahren zur analyse von polynukleotidsequenzen |
| AU2005216549A1 (en) | 2004-02-27 | 2005-09-09 | President And Fellows Of Harvard College | Polony fluorescent in situ sequencing beads |
| WO2006073504A2 (en) | 2004-08-04 | 2006-07-13 | President And Fellows Of Harvard College | Wobble sequencing |
| JP4379284B2 (ja) * | 2004-09-29 | 2009-12-09 | 株式会社日立製作所 | 電子装置 |
| EP1844162B1 (en) | 2005-02-01 | 2014-10-15 | Applied Biosystems, LLC | Method for identifying a sequence in a polynucleotide |
| EP2236628A3 (en) | 2005-02-01 | 2010-10-13 | AB Advanced Genetic Analysis Corporation | Reagents, methods and libraries for bead-based sequencing |
| US20060228720A1 (en) * | 2005-04-12 | 2006-10-12 | Eastman Kodak Company | Method for imaging an array of microspheres |
| US20060229819A1 (en) * | 2005-04-12 | 2006-10-12 | Eastman Kodak Company | Method for imaging an array of microspheres |
| AU2007237909A1 (en) | 2006-04-19 | 2007-10-25 | Applied Biosystems, Llc. | Reagents, methods, and libraries for gel-free bead-based sequencing |
| US9005565B2 (en) | 2010-06-24 | 2015-04-14 | Hamid-Reza Jahangiri-Famenini | Method and apparatus for forming graphene |
| US9809163B2 (en) | 2015-04-14 | 2017-11-07 | Harman International Industries, Incorporation | Techniques for transmitting an alert towards a target area |
| US9805025B2 (en) | 2015-07-13 | 2017-10-31 | Seal Software Limited | Standard exact clause detection |
-
2006
- 2006-02-01 EP EP06720226.7A patent/EP1844162B1/en active Active
- 2006-02-01 EP EP10158872A patent/EP2272983A1/en not_active Withdrawn
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- 2006-02-01 EP EP10158867A patent/EP2239342A3/en not_active Withdrawn
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