KR20070094754A - 이온 채널, 특히 Kv 패밀리로부터의 이온 채널과상호작용하는 5-카복사미도 치환된 티아졸 유도체 - Google Patents
이온 채널, 특히 Kv 패밀리로부터의 이온 채널과상호작용하는 5-카복사미도 치환된 티아졸 유도체 Download PDFInfo
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- KR20070094754A KR20070094754A KR1020077015118A KR20077015118A KR20070094754A KR 20070094754 A KR20070094754 A KR 20070094754A KR 1020077015118 A KR1020077015118 A KR 1020077015118A KR 20077015118 A KR20077015118 A KR 20077015118A KR 20070094754 A KR20070094754 A KR 20070094754A
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- methyl
- phenylamino
- thiazole
- carboxylic acid
- methoxy
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- JFTJHAHTBAFERA-VNXPTHQBSA-N CC(N[C@@H](CCC1)[C@H]1OCc1ccccc1)Br Chemical compound CC(N[C@@H](CCC1)[C@H]1OCc1ccccc1)Br JFTJHAHTBAFERA-VNXPTHQBSA-N 0.000 description 1
- NTENMFKMPURDMT-UHFFFAOYSA-N CC1(C(CCN)C1)N Chemical compound CC1(C(CCN)C1)N NTENMFKMPURDMT-UHFFFAOYSA-N 0.000 description 1
- DNAQTTMNXQBWIL-UHFFFAOYSA-N CC1(C)CCC(C)(C)CC1 Chemical compound CC1(C)CCC(C)(C)CC1 DNAQTTMNXQBWIL-UHFFFAOYSA-N 0.000 description 1
- FXXIUILBLIBKPI-FPOVZHCZSA-N COc1ccccc1Nc1ccc(C(N[C@@H](CCC2)[C@H]2OCc2ccccc2)=O)[s]1 Chemical compound COc1ccccc1Nc1ccc(C(N[C@@H](CCC2)[C@H]2OCc2ccccc2)=O)[s]1 FXXIUILBLIBKPI-FPOVZHCZSA-N 0.000 description 1
- DTFKRVXLBCAIOZ-UHFFFAOYSA-N Cc1ccccc1OC Chemical compound Cc1ccccc1OC DTFKRVXLBCAIOZ-UHFFFAOYSA-N 0.000 description 1
- JIMSXLUBRRQALI-RYUDHWBXSA-N N[C@@H](CCC1)[C@H]1OCc1ccccc1 Chemical compound N[C@@H](CCC1)[C@H]1OCc1ccccc1 JIMSXLUBRRQALI-RYUDHWBXSA-N 0.000 description 1
- ORIONTBOMZNQIE-UHFFFAOYSA-N O=C(c([s]1)ccc1Br)Cl Chemical compound O=C(c([s]1)ccc1Br)Cl ORIONTBOMZNQIE-UHFFFAOYSA-N 0.000 description 1
- COWZPSUDTMGBAT-UHFFFAOYSA-N OC(c([s]1)ccc1Br)=O Chemical compound OC(c([s]1)ccc1Br)=O COWZPSUDTMGBAT-UHFFFAOYSA-N 0.000 description 1
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- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63207204P | 2004-12-01 | 2004-12-01 | |
EP04447268 | 2004-12-01 | ||
EP04447268.6 | 2004-12-01 | ||
US60/632,072 | 2004-12-01 | ||
US68691205P | 2005-06-03 | 2005-06-03 | |
US60/686,912 | 2005-06-03 | ||
EP05077177.3 | 2005-09-22 | ||
EP05077177 | 2005-09-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20070094754A true KR20070094754A (ko) | 2007-09-21 |
Family
ID=36084802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020077015118A KR20070094754A (ko) | 2004-12-01 | 2005-12-01 | 이온 채널, 특히 Kv 패밀리로부터의 이온 채널과상호작용하는 5-카복사미도 치환된 티아졸 유도체 |
Country Status (11)
Country | Link |
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US (1) | US20080125432A1 (de) |
EP (1) | EP1819330A1 (de) |
JP (1) | JP2008521862A (de) |
KR (1) | KR20070094754A (de) |
CN (1) | CN101098698A (de) |
AU (1) | AU2005311251A1 (de) |
BR (1) | BRPI0516915A (de) |
CA (1) | CA2588517A1 (de) |
MX (1) | MX2007006109A (de) |
NO (1) | NO20073357L (de) |
WO (1) | WO2006058905A1 (de) |
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TWI263497B (en) | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
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JP5161871B2 (ja) * | 2006-04-27 | 2013-03-13 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Task−1およびtask−3イオンチャンネルの阻害剤 |
DE102006049527A1 (de) * | 2006-10-20 | 2008-04-24 | Sanofi-Aventis Deutschland Gmbh | Inhibitoren des TASK-1 und TASK-3 Ionenkanals |
DE102006019589A1 (de) * | 2006-04-27 | 2007-10-31 | Sanofi-Aventis Deutschland Gmbh | Inhibitoren des TASK-1 und Task-3 Ionenkanals |
WO2007138110A2 (en) * | 2006-06-01 | 2007-12-06 | Devgen N.V. | Compounds that interact with ion channels, in particular with ion channels from the kv family |
CA2686754C (en) * | 2007-05-11 | 2014-10-28 | F. Hoffmann-La Roche Ag | Hetarylanilines as modulators for amyloid beta |
US8119809B2 (en) | 2007-11-16 | 2012-02-21 | Rigel Pharmaceuticals, Inc. | AMPK-activating heterocycloalkyloxy(hetero)aryl carboxamide, sulfonamide and amine compounds and methods for using the same |
ES2553340T3 (es) | 2007-12-12 | 2015-12-07 | Rigel Pharmaceuticals, Inc. | Compuestos de carboxamida, sulfonamida y amina para trastornos metabólicos |
EP2234999A1 (de) | 2007-12-21 | 2010-10-06 | F. Hoffmann-La Roche AG | Heteroarylderivate als orexinrezeptorantagonisten |
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US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
WO2009087127A1 (en) | 2008-01-11 | 2009-07-16 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
EP2257541B1 (de) | 2008-02-22 | 2013-08-14 | F. Hoffmann-La Roche AG | Modulatoren für amyloid-beta |
CN112079769A (zh) | 2008-04-23 | 2020-12-15 | 里格尔药品股份有限公司 | 用于治疗代谢障碍的甲酰胺化合物 |
US8697866B2 (en) * | 2008-06-19 | 2014-04-15 | Xcovery Holding Company Llc | Substituted pyridazine carboxamide compounds as kinase inhibitor compounds |
AU2009271019A1 (en) | 2008-07-14 | 2010-01-21 | Gilead Sciences, Inc. | Fused heterocyclyc inhibitors of histone deacetylase and/or cyclin-dependent kinases |
US8344018B2 (en) | 2008-07-14 | 2013-01-01 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
WO2010009139A2 (en) | 2008-07-14 | 2010-01-21 | Gilead Colorado, Inc. | Imidazolyl pyrimidine inhibitor compounds |
MX2011001090A (es) | 2008-07-28 | 2011-03-15 | Gilead Sciences Inc | Compuestos de inhibidor de desacetilasa de histona de cicloalquilideno y heterocicloalquilideno. |
CA2736924C (en) | 2008-10-09 | 2016-06-28 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
JP5378532B2 (ja) | 2008-11-10 | 2013-12-25 | エフ.ホフマン−ラ ロシュ アーゲー | 複素環γ−セクレターゼモジュレーター |
WO2010098866A1 (en) | 2009-02-27 | 2010-09-02 | Supergen, Inc. | Cyclopentathiophene/cyclohexathiophene dna methyltransferase inhibitors |
MX2011013166A (es) | 2009-06-08 | 2012-01-30 | Gilead Sciences Inc | Compuestos inhibidores de hdac de cicloalquilcarbamatobenzamida-an ilina. |
EP2440519A1 (de) | 2009-06-08 | 2012-04-18 | Gilead Sciences, Inc. | Alkanoylamino-benzamid-anilin-hdac-hemmerverbindungen |
US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
WO2011123654A1 (en) | 2010-04-02 | 2011-10-06 | Colucid Pharmaceuticals, Inc. | Compositions and methods of synthesis of pyridinoylpiperidine 5-ht1f agonists |
NZ612909A (en) | 2011-01-10 | 2015-09-25 | Infinity Pharmaceuticals Inc | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
IN2014MN02089A (de) | 2012-03-20 | 2015-09-11 | Einstein Coll Med | |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
EP2925316A1 (de) * | 2012-11-28 | 2015-10-07 | Grünenthal GmbH | Substituierte aminoarylcarboxamide als kcnq-2/3-modulatoren |
AU2013351550A1 (en) | 2012-11-28 | 2015-07-16 | Grünenthal GmbH | Specific carboxamides as KCNQ2/3 modulators |
US9248122B2 (en) | 2012-11-28 | 2016-02-02 | Grünenthal GmbH | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators |
WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
CN109640999A (zh) | 2016-06-24 | 2019-04-16 | 无限药品股份有限公司 | 组合疗法 |
WO2018110669A1 (en) | 2016-12-15 | 2018-06-21 | Ono Pharmaceutical Co., Ltd. | Activator of trek (twik related k+ channels) channels |
JP7144863B2 (ja) | 2016-12-28 | 2022-09-30 | ミノリックス セラピューティクス エセ.エレ. | イソキノリン化合物、その調製の方法、およびベータガラクトシダーゼの活性の変質に伴う状態におけるその治療的使用 |
WO2018222795A1 (en) | 2017-06-01 | 2018-12-06 | Bristol-Myers Squibb Company | Substituted nitrogen containing compounds |
RU2768149C2 (ru) * | 2017-06-20 | 2022-03-23 | Раквалиа Фарма Инк. | ПРОИЗВОДНЫЕ АМИДА В КАЧЕСТВЕ БЛОКАТОРОВ Nav1.7 И Nav1.8 |
US20200123147A1 (en) | 2017-06-29 | 2020-04-23 | Bayer Aktiengesellschaft | Thiazole compounds useful as prmt5 inhibitors |
EP3651752A1 (de) | 2017-07-11 | 2020-05-20 | Vertex Pharmaceuticals Incorporated | Carboxamide als modulatoren von natriumkanälen |
US11427531B2 (en) * | 2017-10-09 | 2022-08-30 | Ramot At Tel-Aviv University Ltd. | Modulators of potassium ion and TRPV1 channels and uses thereof |
TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
AR119319A1 (es) | 2019-07-09 | 2021-12-09 | Lilly Co Eli | Procesos e intermediario para la preparación a gran escala de hemisuccinato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida y preparación de acetato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida |
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IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
AU2012199A (en) | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
CA2316218A1 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
WO1999033792A2 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs os aspartyl protease inhibitors |
WO2000062778A1 (en) * | 1999-04-15 | 2000-10-26 | Bristol-Myers Squibb Co. | Cyclic protein tyrosine kinase inhibitors |
US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
AU2003241102A1 (en) * | 2002-05-15 | 2003-12-02 | Devgen Nv | Methods for identifying and developing compounds that interact with voltage-gated potassium channels of the kv4 family |
DE602004028907D1 (de) * | 2003-02-06 | 2010-10-14 | Bristol Myers Squibb Co | Als kinaseinhibitoren geeignete verbindungen auf thiazolylbasis |
-
2005
- 2005-12-01 AU AU2005311251A patent/AU2005311251A1/en not_active Abandoned
- 2005-12-01 CA CA002588517A patent/CA2588517A1/en not_active Abandoned
- 2005-12-01 MX MX2007006109A patent/MX2007006109A/es not_active Application Discontinuation
- 2005-12-01 KR KR1020077015118A patent/KR20070094754A/ko not_active Application Discontinuation
- 2005-12-01 US US11/792,030 patent/US20080125432A1/en not_active Abandoned
- 2005-12-01 EP EP05818954A patent/EP1819330A1/de not_active Withdrawn
- 2005-12-01 JP JP2007543849A patent/JP2008521862A/ja not_active Withdrawn
- 2005-12-01 WO PCT/EP2005/056390 patent/WO2006058905A1/en active Application Filing
- 2005-12-01 BR BRPI0516915-1A patent/BRPI0516915A/pt not_active IP Right Cessation
- 2005-12-01 CN CNA2005800460095A patent/CN101098698A/zh active Pending
-
2007
- 2007-06-29 NO NO20073357A patent/NO20073357L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2008521862A (ja) | 2008-06-26 |
NO20073357L (no) | 2007-08-30 |
EP1819330A1 (de) | 2007-08-22 |
WO2006058905A1 (en) | 2006-06-08 |
AU2005311251A1 (en) | 2006-06-08 |
US20080125432A1 (en) | 2008-05-29 |
MX2007006109A (es) | 2007-10-04 |
CA2588517A1 (en) | 2006-06-08 |
BRPI0516915A (pt) | 2008-03-11 |
CN101098698A (zh) | 2008-01-02 |
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