KR20070087032A - 막 합성 및 막 운반 관련 단백질을 코딩하는코리네박테리움 글루타미쿰 유전자 - Google Patents
막 합성 및 막 운반 관련 단백질을 코딩하는코리네박테리움 글루타미쿰 유전자 Download PDFInfo
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Abstract
본 발명은 코리네박테리움 글루타미쿰 (Corynebacterium glutamicum)으로부터 신규 MCT 단백질을 코딩하는, MCT 핵산 분자로 명명된 단리된 핵산 분자를 기재한다. 본 발명은 또한 안티센스 핵산 분자, MCT 핵산 분자를 함유하는 재조합 발현 벡터 및 발현 벡터가 도입된 숙주 세포를 제공한다. 또한, 본 발명은 단리된 MCT 단백질, MCT 단백질 돌연변이, 융합 단백질, 항원성 펩티드, 및 코리네박테리움 글루타미쿰에서 MCT 유전자의 유전 공학을 기초로 하여 상기 생물체로부터 목적하는 화합물의 생산을 향상시키는 방법을 제공한다.
코리네박테리움 글루타미쿰, MCT 단백질, 핵산 분자, 재조합 발현 벡터.
Description
관련 출원
본 출원은 본 출원일 이전에 출원된 미국 가특허 출원 제60/141031호 (1999년 6월 25일 출원)을 우선권으로 주장한다. 본 출원은 또한 독일 특허 출원 제19931454.3호 (1999년 7월 8일 출원), 독일 특허 출원 제19931478.0호 (1999년 7월 8일 출원), 독일 특허 출원 제19931563.9호 (1999년 7월 8일 출원), 독일 특허 출원 제19932122.1호 (1999년 7월 9일 출원), 독일 특허 출원 제19932124.8호 (1999년 7월 9일 출원), 독일 특허 출원 제19932125.6호 (1999년 7월 9일 출원), 독일 특허 출원 제19932128.0호 (1999년 7월 9일 출원), 독일 특허 출원 제19932180.9호 (1999년 7월 9일 출원), 독일 특허 출원 제19932182.5호 (1999년 7월 9일 출원), 독일 특허 출원 제19932190.6호 (1999년 7월 9일 출원), 독일 특허 출원 제19932191.4호 (1999년 7월 9일 출원), 독일 특허 출원 제19932209.0호 (1999년 7월 9일 출원), 독일 특허 출원 제19932212.0호 (1999년 7월 9일 출원), 독일 특허 출 원 제19932227.9호 (1999년 7월 9일 출원), 독일 특허 출원 제19932228.7호 (1999년 7월 9일 출원), 독일 특허 출원 제19932229.5호 (1999년 7월 9일 출원), 독일 특허 출원 제19932230.9호 (1999년 7월 9일 출원), 독일 특허 출원 제19932927.3호 (1999년 7월 14일 출원), 독일 특허 출원 제19933005.0호 (1999년 7월 14일 출원), 독일 특허 출원 제19933006.9호 (1999년 7월 14일 출원), 독일 특허 출원 제19940764.9호 (1999년 8월 27일 출원), 독일 특허 출원 제19940765.7호 (1999년 8월 27일 출원), 독일 특허 출원 제19940766.5호 (1999년 8월 27일 출원), 독일 특허 출원 제19940830.0호 (1999년 8월 27일 출원), 독일 특허 출원 제19940831.9호 (1999년 8월 27일 출원), 독일 특허 출원 제19940832.7호 (1999년 8월 27일 출원), 독일 특허 출원 제19940833.5호 (1999년 8월 27일 출원), 독일 특허 출원 제19941378.9호 (1999년 8월 31일 출원), 독일 특허 출원 제19941379.7호 (1999년 8월 31일 출원), 독일 특허 출원 제19941395.9호 (1999년 8월 31일 출원), 독일 특허 출원 제19942077.7호 (1999년 9월 3일 출원), 독일 특허 출원 제19942078.5호 (1999년 9월 3일 출원), 독일 특허 출원 제19942079.3호 (1999년 9월 3일 출원), 및 독일 특허 출원 제19942088.2호 (1999년 9월 3일 출원)을 우선권으로 주장한다. 상기 모든 출원의 전체 내용은 본원의 참고 문헌에 명백히 포함된다.
세포에서 자연발생적으로 일어나는 대사 과정의 일부 산물 및 부산물은 식품, 사료, 화장품 및 제약 산업을 비롯한 다양한 산업 분야에 사용된다. 총체적으로 "정밀 화학물질"로 불리는 이들 분자로는 유기산, 단백질원성 및 비단백질원성 아미노산, 뉴클레오티드 및 뉴클레오시드, 지질 및 지방산, 디올, 탄수화물, 방향족 화합물, 비타민 및 보조인자, 및 효소가 있다. 이들의 생성은 원하는 특정 분자를 대량으로 생산하고 분비하도록 개발된 박테리아의 대규모 배양을 통해 가장 편리하게 수행된다. 이러한 목적에 특히 유용한 생물체는 그람 양성의 비병원성 박테리아인 코리네박테리움 글루타미쿰이다. 균주 선별을 통해, 일련의 바람직한 화합물을 생산하는 다수의 돌연변이 균주가 개발되어 있다. 그러나, 특정 분자의 생산을 위해 개량된 균주의 선별은 시간 소모적이고 어려운 과정이다.
<발명의 요약>
본 발명은 다양한 용도를 갖는 신규 박테리아 핵산 분자를 제공한다. 이들 은 정밀 화학물질의 생산에 사용될 수 있는 미생물의 확인; 코리네박테리움 글루타미쿰 또는 관련 박테리아에서의 정밀 화학물질의 생산 조절; 코리네박테리움 글루타미쿰 또는 관련 박테리아의 타이핑 또는 확인; 코리네박테리움 글루타미쿰의 게놈을 맵핑하기 위한 기준점 및 형질전환용 마커로서의 용도로 사용된다. 이들 신규 핵산 분자는 본원에서 막 구성 및 막 운반 (MCT) 단백질로 불리는 단백질을 코딩한다.
코리네박테리움 글루타미쿰은 다양한 정밀 화학물질의 대량 생산, 탄화수소의 분해 (예컨대, 광유 스필) 및 테르페노이드의 산화를 위해 공업적으로 통상 사용되는 그람 양성 호기성 박테리아이다. 따라서, 본 발명의 MCT 핵산 분자는 예를 들어, 발효 공정에 의해 정밀 화학물질을 생산하는 데 이용할 수 있는 미생물을 확 인하는 데 사용할 수 있다. 본 발명의 MCT 핵산의 발현 조절 또는 본 발명의 MCT 핵산 분자의 서열 변이를 이용하여 미생물로부터 하나 이상의 정밀 화학물질을 생산하는 것을 조절할 수 있다 (예를 들어, 코리네박테리움 또는 브레비박테리움 종으로부터 하나 이상의 정밀 화학물질을 수득하거나 생산하는 것을 개선하기 위함).
본 발명의 MCT 핵산은 코리네박테리움 글루타미쿰 또는 그와 가까운 동족체일 수 있는 생물체를 확인하거나, 혼합된 미생물 집단에서 코리네박테리움 글루타미쿰 또는 그와 가까운 동족체의 존재를 확인하는 데 사용할 수도 있다. 본 발명은 동일 또는 혼합 미생물 집단의 배양물 중의 추출 게놈 DNA를 엄격한 조건 하에 코리네박테리움 글루타미쿰에 고유한 코리네박테리움 글루타미쿰 유전자 영역에 걸친 프로브를 사용하여 탐침함으로써 상기 생물체의 존재를 확인할 수 있는 다수의 코리네박테리움 글루타미쿰 유전자의 핵산 서열을 제공한다. 비록 코리네박테리움 글루타미쿰 자체가 병원성이 아닐지라도, 코리네박테리움 디프테리아 (디프테리아의 병원체)와 같은, 인간에게 병원성인 종과 관련되어 있고, 이러한 생물체의 검출은 임상적으로 상당히 중요하다.
본 발명의 MCT 핵산 분자는 코리네박테리움 글루타미쿰의 게놈 또는 관련 생물체의 게놈을 맵핑하기 위한 기준점으로도 사용할 수 있다. 유사하게, 이들 분자, 그의 변이체 또는 일부는 유전공학적으로 조작된 코리네박테리움 또는 브레비박테리움 종을 위한 마커로 사용할 수 있다.
본 발명의 신규 핵산 분자에 의해 코딩되는 MCT 단백질은 예를 들어, 막 생합성에 필요한 화합물의 대사 (예를 들어, 생합성 또는 분해)에 관련된 기능을 수 행하거나, 세포내로 또는 세포로부터 1종 이상의 화합물의 막횡단 운반을 보조할 수 있다. 미국 특허 제4,649,119호 (Sinskey et al.)에 개시된 클로닝 벡터와 같은 코리네박테리움 글루타미쿰에 사용하기 위한 클로닝 벡터, 및 코리네박테리움 글루타미쿰 및 관련된 브레비박테리움 종(예컨대, 락토페르멘툼)의 유전 조작 기술 (Yoshihama et al, J. Bacteriol. 162: 591-597 (1985); Katsumata et al., J. Bacteriol. 159: 306-311 (1984); and Santamaria et al., J. Gen. Microbiol. 130: 22372246 (1984))을 이용하여, 본 발명의 핵산 분자를 이 생물체가 하나 이상의 정밀 화학물질의 보다 효율적인 생산자가 되도록 상기 생물체의 유전공학적 조작에 사용할 수 있다. 본 발명의 유전자 조작은 정밀 화학물질의 생산 또는 생산 효율에 직접적으로 또는 간접적으로 영향을 줄 수 있다.
본 발명의 MCT 단백질의 변형에 의해 상기 변형된 단백질을 포함하는 코리네박테리움 글루타미쿰 균주로부터 정밀 화학물질의 수율, 생산 및(또는) 생산 효율에 직접적으로 영향을 줄 수 있는 여러 기작이 있다. 세포로부터의 정밀 화학물질 분자의 배출에 관여하는 이러한 MCT 단백질을, 이러한 화합물이 보다 쉽게 회수되는 세포외 매질로 더 많은 양이 분비되도록, 그의 수 또는 활성을 증가시킬 수 있다. 마찬가지로, 1종 이상의 정밀 화학물질의 생합성에 필요한 영양분(예를 들어, 포스페이트, 술페이트, 질소 화합물 등)의 유입에 관여하는 MCT 단백질을, 이러한 전구체, 보조인자 또는 중간체 화합물의 세포내 농도가 증가되도록, 그의 수 또는 활성을 증가시킬 수 있다. 또한, 지방산 및 지질 자체는 바람직한 정밀 화학물질이며, 이러한 화합물의 생합성에 관여하는 1종 이상의 본 발명의 MCT 단백질의 활 성을 최적화하거나 또는 그의 수를 증가시킴으로써, 또는 이러한 화합물의 분해에 관여하는 1종 이상의 MCT 단백질의 활성을 손상시킴으로써, 코리네박테리움 글루타미쿰으로부터 지방산 및 지질 분자의 수율, 생산 및(또는) 생산 효율을 증가시킬 수 있다.
또한, 본 발명의 하나 이상의 MCT 유전자에 돌연변이를 유발시켜 코리네박테리움 글루타미쿰으로부터 1종 이상의 목적하는 정밀 화학물질을 생산하는데 간접적으로 영향을 주는, 활성이 변화된 MCT 단백질을 제조할 수 있다. 예를 들어, 폐 생성물의 배출에 관여하는 본 발명의 MCT 단백질을, 세포의 정상적인 대사성 폐기물(목적하는 정밀 화학물질의 과다생산으로 인해 양이 증가될 수 있음)이 세포내에서 뉴클레오티드 및 단백질을 손상시키거나(세포의 생존율이 감소됨) 또는 정밀 화학물질 생합성 경로를 방해하기(목적하는 정밀 화학물질의 수율, 생산 또는 생산 효율이 저하됨) 전에 효과적으로 배출되도록, 그의 수 또는 활성을 증가시킬 수 있다. 또한, 세포내에서 비교적 다량인 정밀 화학물질은 그 자체로도 세포에 독성을 띨 수 있어서, 세로로부터 이 화합물을 배출시킬 수 있는 운반자의 활성 또는 수를 증가시킴으로써, 배양물내 세포의 생존율을 증가시킬 수 있고, 다시 말하면, 배양물내에서 목적하는 정밀 화학물질을 생산하는 세포수를 더 증가시킬 수 있다. 적절한 양의 다른 지질 및 지방산 분자가 생산되도록 본 발명의 MCT 단백질을 조작할 수도 있다. 이는 세포막의 지질 조성에 중요한 영향을 줄 수 있다. 각 지질 타입은 다른 물리적 특성을 가지기 때문에, 막의 지질 조성에 있어서의 변화는 막의 유동성을 상당히 변화시킬 수 있다. 막 유동성에서의 변화는 막을 통한 분자의 운반 뿐 아니라 세포의 일체성에 영향을 줄 수 있으며, 이들 모두는 대규모 발효 배양에서 코리네박테리움 글루타미쿰으로부터 정밀 화학물질의 생산에 상당한 영항을 준다.
본 발명은 예를 들어 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여할 수 있는, 본원에서 MCT 단백질로 언급되는 단백질을 코딩하는 신규 핵산 분자를 제공한다. MCT 단백질을 코딩하는 핵산 분자는 본원에서 MCT 핵산 분자로 언급된다. 바람직한 실시양태에서, MCT 단백질은 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여한다. 이러한 단백질의 예로는 하기 표 1의 유전자 세트에 의해 코딩되는 것들이 포함된다.
따라서, 본 발명의 한 측면은 MCT 단백질 또는 그의 생물학적 활성 일부를 코딩하는 뉴클레오티드 서열을 포함하는 단리된 핵산 분자 (예를 들어, cDNA, DNA 또는 RNA) 뿐만 아니라 MCT 코딩 핵산 (예를 들어, DNA 또는 mRNA)의 검출 또는 증폭을 위한 프라이머 또는 혼성화 프로브로서 적합한 핵산 단편에 관한 것이다. 특히 바람직한 실시양태에서, 단리된 핵산 분자는 서열 목록에 있는 홀수 번호 서열로 기재된 뉴클레오티드 서열 (예를 들어, 서열 1, 서열 3, 서열 5, 서열 7....) 중 하나, 또는 이들 뉴클레오티드 서열 중 하나의 코딩 영역 또는 그의 상보체를 포함한다. 특히 바람직한 다른 실시양태에서, 본 발명의 단리된 핵산 분자는 서열 목록에 있는 홀수 번호 서열 (예를 들어, 서열 1, 서열 3, 서열 5, 서열 7....)로 기재된 뉴클레오티드 서열 또는 그의 일부와 혼성화하거나, 약 50% 이상, 바람직하 게는 약 60% 이상, 보다 바람직하게는 약 70%, 80% 또는 90% 이상, 훨씬 더 바람직하게는 약 95%, 96%, 97%, 98%, 99% 이상 또는 그 이상의 상동성이 있는 뉴클레오티드 서열을 포함한다. 다른 바람직한 실시양태에서, 단리된 핵산 분자는 서열 목록 중의 짝수 번호 서열 (예를 들어, 서열 2, 서열 4, 서열 6, 서열 8....)로 기재된 아미노산 서열 중 하나를 코딩한다. 본 발명의 바람직한 MCT 단백질은 본원에 기재된 MCT 활성 중 적어도 하나를 갖는 것도 바람직하다.
다른 실시양태에서, 단리된 핵산 분자는 단백질 또는 그의 일부를 코딩하는데, 여기서 상기 단백질 또는 그의 일부는 본 발명의 아미노산 서열과 충분한 상동성이 있는 아미노산 서열 (예를 들어, 서열 목록 중의 짝수 번호 서열을 갖는 서열), 예를 들어, 상기 단백질 또는 그의 일부가 MCT 활성을 유지할 수 있을 만큼 본 발명의 아미노산 서열과 충분한 상동성이 있는 아미노산 서열을 포함한다. 바람직하게는, 상기 핵산 분자에 의해 코딩되는 단백질 또는 그의 일부는 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여하는 능력을 유지한다. 한 실시양태에서, 상기 핵산 분자에 의해 코딩되는 단백질은 본 발명의 아미노산 서열 (예컨대, 서열 목록 중의 짝수 번호 서열을 갖는 서열로부터 선택된 전체 아미노산 서열)과 약 50% 이상, 바람직하게는 약 60% 이상, 보다 바람직하게는 약 70%, 80% 또는 90% 이상, 가장 바람직하게는 약 95%, 96%, 97%, 98% 또는 99% 이상, 또는 그 이상의 상동성이 있다. 다른 바람직한 실시양태에서, 상기 단백질은 본 발명의 전체 아미노산 서열 (서열 목록 중의 상응하는 홀수 번호 서열 (예를 들어, 서열 1, 서열 3, 서열 5, 서열 7....)에 나 타낸 오픈 리딩 프레임에 의해 코딩됨)과 실질적으로 상동성이 있는 전장의 코리네박테리움 글루타미쿰 단백질이다.
다른 바람직한 실시양태에서, 단리된 핵산 분자는 코리네박테리움 글루타미쿰으로부터 유래하고, 본 발명의 아미노산 서열 중 하나 (예를 들어, 서열 목록 중의 짝수 번호 서열 중 하나의 서열)와 약 50% 이상 또는 그 이상의 상동성이 있으며 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여할 수 있거나, 표 1에 기재된 활성 중 하나 이상을 갖는 생물학적 활성 도메인을 포함하며, 이종 폴리펩티드 또는 조절 영역을 코딩하는 이종 핵산 서열도 포함하는 단백질 (예를 들어, MCT 융합 단백질)을 코딩한다.
다른 실시양태에서, 단리된 핵산 분자는 그 길이가 15개의 뉴클레오티드 이상이고 본 발명의 뉴클레오티드 서열 (예를 들어, 서열 목록 중의 홀수 번호 서열)을 포함하는 핵산 분자와 엄격한 조건 하에 혼성화한다. 바람직하게는, 단리된 핵산 분자는 자연 발생 핵산 분자에 상응한다. 보다 바람직하게는, 단리된 핵산은 코리네박테리움 글루타미쿰의 MCT 단백질 또는 그의 생물학적 활성 부위를 코딩한다.
본 발명의 다른 측면은 본 발명의 핵산 분자를 포함하는 벡터, 예를 들어, 재조합 벡터, 및 이러한 벡터가 도입된 숙주 세포에 관한 것이다. 한 실시양태에서, 상기 숙주 세포는 숙주 세포를 적당한 배지에서 배양하여 MCT 단백질을 생산하는 데 사용한다. 이어서, MCT 단백질을 배지 또는 숙주 세포로부터 단리할 수 있다.
본 발명의 또 다른 측면은 MCT 유전자가 도입되거나 변이된 유전 변이 미생물에 관한 것이다. 한 실시양태에서, 미생물의 게놈은 야생형 또는 돌연변이 MCT 서열을 코딩하는 본 발명의 핵산 분자를 트랜스진으로서 도입하여 변이시킨다. 다른 실시양태에서, 미생물의 게놈 내의 내인성 MCT 유전자는 변이된 MCT 유전자와의 상동 재조합에 의해 변이되고, 예를 들어, 기능적으로 파괴 (disrupt)된다. 다른 실시양태에서, 미생물 내의 내인성 또는 도입 MCT 유전자는 하나 이상의 점 돌연변이, 결실 또는 역위에 의해 변이되었지만, 여전히 기능성 MCT 단백질을 코딩한다. 다른 실시양태에서, 미생물에 있는 MCT 유전자의 하나 이상의 조절 영역 (예를 들어, 프로모터, 억제자 (repressor) 또는 인듀서 (inducer))을 (예를 들어, 결실, 말단의 절단 (truncation), 역위 또는 점 돌연변이에 의해) 변이시켜 MCT 유전자의 발현을 조절한다. 바람직한 실시양태에서, 상기 미생물은 코리네박테리움 또는 브레비박테리움 속, 특히 바람직하게는 코리네박테리움 글루타미쿰에 속한다. 바람직한 실시양태에서, 상기 미생물은 아미노산, 특히 바람직하게는 라이신과 같은 원하는 화합물의 생산에도 사용된다.
또다른 측면에서, 본 발명은 한 대상체에서 코리네박테리움 디프테리아의 존재 또는 활성을 확인하는 방법을 제공한다. 이 방법은 한 대상체에서 본 발명의 하나 이상의 핵산 또는 아미노산 서열을 검출하는 것을 포함하므로 (예컨대, 서열 1 내지 676으로서 서열 목록에 기재된 서열), 상기 대상체에서 코리네박테리움 디프테리아의 존재 또는 활성을 검출할 수 있다.
본 발명의 다른 측면은 단리된 MCT 단백질 또는 그의 일부, 예를 들어, 그의 생물학적 활성 부위에 관한 것이다. 바람직한 실시양태에서, 단리된 MCT 단백질 또는 그의 일부는 코리네박테리움 글루타미쿰에서 당과 같은 탄소 화합물의 대사 또는 산화적 인산화와 같은 과정에 의한 에너지 분자 (예, ATP)의 생산과 관련된 기능을 수행할 수 있다. 또 다른 바람직한 실시양태에서, 단리된 MCT 단백질 또는 그의 일부가 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여하는 능력을 유지하도록 이 MCT 단백질 또는 그의 일부는 본 발명의 아미노산 서열(예를 들어, 서열 목록에서 짝수 서열 번호의 서열)에 대해 충분히 상동성이 있다.
본 발명은 MCT 단백질의 단리된 제제를 제공한다. 바람직한 실시양태에서, MCT 단백질은 본 발명의 아미노산 서열 (예를 들어, 서열 목록 중의 짝수 번호 서열)을 포함한다. 또 다른 바람직한 실시양태에서, 본 발명은 본 발명의 전체 아미노산 서열 (서열 목록 중의 짝수 번호 서열)과 실질적으로 상동성이 있는 단리된 전장 단백질 (서열 목록 중의 상응하는 홀수 번호 서열에 기재된 오픈 리딩 프레임에 의해 코딩됨)에 관한 것이다. 또 다른 실시양태에서, 상기 단백질은 본 발명의 전체 아미노산 서열 (예를 들어, 서열 목록 중의 짝수 번호 서열)과 약 50% 이상, 바람직하게는 약 60% 이상, 보다 바람직하게는 약 70%, 80% 또는 90% 이상, 가장 바람직하게는 약 95%, 약 96%, 약 97%, 약 98% 또는 약 99% 이상, 또는 그 이상의 상동성이 있다. 다른 실시양태에서, 단리된 MCT 단백질은 본 발명의 아미노산 서열 (예를 들어, 서열 목록 중의 짝수 번호 서열) 중 하나와 약 50% 이상 또는 그 이상의 상동성이 있는 아미노산 서열을 포함하고, 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여할 수 있거나, 표 1에 기재된 하나 이상의 활성을 갖는다.
별법으로, 단리된 MCT 단백질은 서열 목록에 기재된 짝수 번호 서열 중 하나의 뉴클레오티드 서열과 혼성화하거나, 예를 들어, 엄격한 조건 하에서 혼성화하거나, 약 50% 이상, 바람직하게는 약 60% 이상, 보다 바람직하게는 약 70%, 80% 또는 90% 이상, 가장 바람직하게는 약 95%, 약 96%, 약 97%, 약 98% 또는 약 99% 이상, 또는 그 이상의 상동성이 있는 뉴클레오티드 서열에 의해 코딩되는 아미노산 서열을 포함할 수 있다. 또한, MCT 단백질의 바람직한 형태가 본원에 기재된 하나 이상의 MCT 생물활성을 갖는 것이 바람직하다.
MCT 폴리펩티드 또는 그의 생물학적 활성 부위를 MCT 폴리펩티드가 아닌 폴리펩티드와 작동가능하게 결합하여 융합 단백질을 형성할 수 있다. 바람직한 실시양태에서, 이 융합 단백질의 활성은 MCT 단백질만의 활성과 다르다. 바람직한 실시양태에서, 이 융합 단백질은 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여한다. 특히 바람직한 실시양태에서, 이 융합 단백질을 숙주 세포에 도입시켜 숙주 세포로부터 원하는 화합물의 생산을 조절한다.
또 다른 측면에서, 본 발명은 MCT 단백질 자체, 이 MCT 단백질의 기질 또는 결합 파트너와 상호작용시키거나 본 발명의 MCT 핵산 분자의 전사 또는 번역을 조절함으로써 MCT 단백질의 활성을 조절하는 분자를 스크리닝하기 위한 방법을 제공한다.
본 발명의 또 다른 측면은 정밀 화학물질의 제조 방법에 관한 것이다. 이 방법은 본 발명의 MCT 핵산 분자를 발현하는 벡터를 포함하는 세포를 배양하여 정밀 화학물질을 생산하는 것을 포함한다. 바람직한 실시양태에서, 이 방법은 MCT 핵산을 발현하는 벡터로 세포를 형질감염시켜 상기 벡터를 함유하는 세포를 수득하는 단계도 포함한다. 또 다른 바람직한 실시양태에서, 이 방법은 배양물로부터 정밀 화학물질을 회수하는 단계도 포함한다. 특히 바람직한 실시양태에서, 상기 세포는 코리네박테리움 또는 브레비박테리움 속으로부터 유래하거나 표 3에 기재된 균주로부터 선택된다.
본 발명의 또 다른 측면은 미생물로부터 분자가 생산을 조절하는 방법에 관한 것이다. 이러한 방법은 MCT 단백질 활성 또는 MCT 핵산 발현을 조절하는 물질과 세포를 접촉시켜 세포 관련 활성이 상기 물질의 부재 하의 상기 활성에 대해 상대적으로 변화시키는 것을 포함한다. 바람직한 실시양태에서, 코리네박테리움 글루타미쿰의 세포막 성분에 대한 하나 이상의 대사 경로 또는 이 막을 통한 화합물의 운반에 대하여 세포를 조절하여, 이 미생물에 의한 목적하는 정밀 화학물질의 수율 또는 생성율을 향상시킨다. MCT 단백질 활성을 조절하는 물질은 MCT 단백질 활성 또는 MCT 핵산 발현을 자극하는 물질일 수 있다. MCT 단백질 활성 또는 MCT 핵산 발현을 자극하는 물질의 예로는 소분자, 활성 MCT 단백질, 및 세포에 도입된 MCT 단백질을 코딩하는 핵산이 있다. MCT 활성 또는 발현을 억제하는 물질의 예로는 소분자 및 안티센스 MCT 핵산 분자가 있다.
본 발명의 또 다른 측면은 별개의 플라스미드 상에 유지되어 있거나 숙주 세 포의 게놈 내로 도입되어 있도록 야생형 또는 돌연변이 MCT 유전자를 세포에 도입하는 것을 포함하는, 세포로부터 목적하는 화합물의 수율을 조절하는 방법에 관한 것이다. 게놈 내로 삽입되면 (이러한 삽입은 무작위적일 수 있거나 천연 유전자가 도입된 카피로 대체되도록 하는 상동 재조합에 의해 일어날 수 있음) 세포로부터 목적하는 화합물의 생산이 조절된다. 바람직한 실시양태에서, 상기 수율은 증가한다. 또 다른 바람직한 실시양태에서, 상기 화학물질은 정밀 화학물질이다. 특히 바람직한 실시양태에서, 상기 정밀 화학물질은 아미노산이다. 특히 바람직한 실시양태에서, 상기 아미노산은 L-라이신이다.
본 발명은 코리네박테리움 글루타미쿰에서 세포막 성분의 대사 또는 이 막을 통한 화합물의 운반에 관여하는 MCT 핵산 및 단백질 분자를 제공한다. 본 발명의 분자는 코리네박테리움 글루타미쿰과 같은 미생물로부터 정밀 화학물질의 생산을 직접적으로 조절하는 데 사용할 수 있거나 (예를 들어, 지방산 생합성 단백질의 과다 발현 또는 최적화가 변형된 코리네박테리움 글루타미쿰으로부터 지방산의 수율, 생산, 및(또는) 생산 효율에 직접적으로 영향을 주는 경우), 또는 목적하는 화합물의 수율, 생산 및(또는) 생산 효율의 증가에 간접적으로 영향을 줄 수 있다 (예를 들어, 세포막 성분의 대사 조절은 수율, 생산 및(또는) 생산 효율, 또는 세포막의 조성을 변화시켜, 즉 1종 이상의 정밀 화학물질의 생산에 영향을 줄 수 있는 경우). 본 발명의 측면은 아래에 더 자세히 기재되어 있다.
I. 정밀 화학물질
용어 "정밀 화학물질"은 당업계에 잘 인지되어 있고, 제약, 농업 및 화장품 산업과 같은, 그러나 이에 제한되지 않는 다양한 산업에 이용되는 생물체에 의해 생산되는 분자를 포함한다. 이러한 화합물로는 타르타르산, 이타콘산 및 디아미노피멜산과 같은 유기산, 단백질원성 및 비단백질원성 아미노산, 퓨린 및 피리미딘 염기, 뉴클레오시드, 및 뉴클레오티드 [예를 들어, 문헌 (Kuninaka, A. (1996) Nucleotides and related compounds, p. 561-612, in Biotechnology vol. 6, Rehm et al., eds. VCH: Weinheim)에 기재되어 있고 이들의 내용은 본 명세서에 포함되는 것으로 함), 지질, 포화 및 불포화 지방산 (예컨대, 아라키돈산), 디올 (예를 들어, 프로판디올 및 부탄디올), 탄수화물 (예를 들어, 히알루론산 및 트레할로스), 방향족 화합물 (예를 들어,방향족 아민, 바닐린 및 인디고), 비타민 및 보조인자 [문헌 (Ullmann's Encyclopedia of Industrial Chemistry, vol. A27,"Vitamins", p. 443-613 (1996) VCH: Weinheim) 및 그에 포함된 참고문헌; 및 문헌(Ong, A. S., Niki, E. & Packer, L. (1995)"Nutrition, Lipids, Health, and Disease" Proceedings of the UNESCO/Confederation of Scientific and Technological Associations in Malaysia, and the Society for Free Radical Research Asia, held Sept. 1-3,1994 at Penang, Malaysia, AOCS Press, (1995)에 기재되어 있음], 효소, 폴리펩티드 (Cane et al. (1998) Science 282: 63-68), 및 문헌 (Gutcho (1983) Chemicals by Fermentation, Noyes Data Corporation, ISBN: 0818805086) 및 그 내의 참고문헌에 기재된 다른 모든 화학물질이 있다. 이들 정밀 화학물질 중 일부의 대사 및 용도는 아래에 더 자세히 기재될 것이다.
A. 아미노산 대사 및 용도
아미노산은 모든 단백질의 기본 구조 단위를 구성하므로 모든 생물체에서 정상적인 세포 기능에 필수적이다. 용어 "아미노산"은 당업계에 인지되어 있다. 아미노산 중 단백질원성 아미노산은 20 종이고 이들이 펩티드 결합에 의해 결합되어 있는 단백질에 대한 구조 단위로 작용하는 반면, 비단백질원성 아미노산 (수백 종이 공지되어 있음) 정상적으로는 단백질에서 발견되지 않는다 [문헌 Ulmann's Encyclopedia of Industrial Chemistry, vol. A2, p. 57-97 VCH: Weinheim (1985)을 참조함]. 비록 L-아미노산이 일반적으로 천연 발생 단백질에서 발견되는 유일한 형태일지라도 아미노산은 D-광학 또는 L-광학 구조일 수 있다. 20종의 단백질원성 아미노산 각각의 생합성 및 분해 경로의 특징은 원핵세포 및 진핵세포 둘다에서 잘 규명되어 있다 [예를 들어, 문헌 (Stryer, L. Biochemistry, 3rd edition, pages 578-590 (1988))을 참조함]. 생합성의 복잡성으로 인한 일반적인 영양 요구물이기 때문에 "필수" 아미노산이라고 불리는 아미노산 (히스티딘, 이소류신, 류신, 라이신, 메티오닌, 페닐알라닌, 트레오닌, 트립토판 및 발린)은 단순한 생합성 경로에 의해 나머지 11종의 "비필수" 아미노산 (알라닌, 아르기닌, 아스파라진, 아스파르테이트, 시스테인, 글루타메이트, 글루타민, 글리신, 프롤린, 세린 및 티로신)으로 쉽게 전환된다. 고등동물은 필수 아미노산 중 일부를 합성하는 능력을 보유하지만, 상기 필수 아미노산은 식사로부터 공급되어야 정상적인 단백질 합성이 일어난다.
단백질 생합성에서의 아미노산의 기능 이외에, 이들 아미노산은 그 자체가 흥미로운 화학물질이고, 다수의 아미노산이 식품, 사료, 화학물질, 화장품, 농업 및 제약 산업에 다양하게 사용될 수 있는 것으로 밝혀져 있다. 라이신은 인간 뿐만 아니라 가금 및 돼지와 같은 단위동물의 영양에 있어서도 중요한 아미노산이다. 글루타메이트는 향미제 첨가물 (모노-소듐 글루타메이트, MSG)로서 가장 흔히 사용되고, 아스파르테이트, 페닐알라닌, 글리신 및 시트테인도 식품 산업 전반에 걸쳐 광범위하게 사용된다. 글리신, L-메티오닌 및 트립토판은 모두 제약 산업에 사용된다. 글루타민, 발린, 류신, 이소류신, 히스티딘, 아르기닌, 프롤린, 세린 및 알라닌은 제약 및 화장품 산업 둘다에 사용된다. 트레오닌, 트립토판 및 D/L-메티오닌은 통상적인 사료 첨가제이다 (Leuchtenberger, W. (1996) Amino acids technical production and use, p. 466-502 in Rehm et al. (eds.) Biotechnology vol. 6, chapter 14a, VCH: Weinheim). 또한, 이들 아미노산은 합성 아미노산 및 단백질, 예컨대, N-아세틸시스테인, S-카르복시메틸-L-시스테인, (S)-5-히드록시트립토판, 및 문헌 (Ulmann's Encyclopedia of Industrial Chemistry, vol. A2, p. 57-97, VCH: Weinheim, 1985)에 기재된 다른 것의 합성을 위한 전구체로 유용하다는 것이 밝혀져 있다.
이들 천연 아미노산을 생산할 수 있는 생물체, 예컨대, 박테리아에서의 이들 천연 아미노산의 생합성의 특징은 잘 규명되어 있다 [박테리아 아미노산 생합성 및 그의 조절에 대한 자세한 것은 문헌 (Umbarger, H. E. (1978) Ann. Rev. Biochem. 47: 533-606)을 참조함]. 글루타메이트는 시트르산 사이클의 중간체인 α-케토글루타레이트의 환원 아미노화에 의해 합성된다. 그 다음에 글루타민, 프롤린 및 아르기닌 각각이 글루타메이트로부터 생성된다. 세린의 생합성은 3-포스포글리세레 이트 (해당작용의 중간체)로 시작되며, 산화, 트랜스아미노화 및 가수분해 단계 후 세린을 생성하는 3 단계 과정이다. 시스테인 및 글리신 둘다 세린으로부터 생성되는데, 시스테인은 호모시스테인과 세린의 축합에 의해 생성되며, 글리신은 세린 트랜스히드록시메틸라제에 의해 촉매되는 반응에서 측쇄 β-탄소 원자가 테트라히드로폴레이트로 전달되어 생성된다. 페닐알라닌 및 티로신은 프레페네이트의 합성 후 최종 두 단계에서만 다른 9 단계 생합성 경로에서 해당작용 및 펜토스 포스페이트 경로 전구체인 에리쓰로스 4-포스페이트 및 포스포에놀피루베이트로부터 합성된다. 트립토판도 이들 두 초기 분자로부터 합성되지만, 그의 합성은 11 단계 경로이다. 티로신은 페닐알라닌 히드록실라제에 의해 촉매되는 반응에서 페닐알라닌으로부터 합성될 수도 있다. 알라닌, 발린 및 류신은 해당작용의 최종 생성물인 피루베이트의 모든 생합성 산물이다. 아스파르테이트는 시트르산 사이클의 중간체인 옥살로아세테이트로부터 형성된다. 아스파라진, 메티오닌, 트레오닌 및 라이신 각각은 아스파르테이트의 전환에 의해 생성된다. 이소류신은 트레오닌으로부터 형성된다. 복잡한 9 단계 경로에서 활성화된 당인 5-포스포리보실-1-피로포스페이트로부터 히스티딘이 생성된다.
세포의 단백질 합성 필요량을 초과하는 아미노산은 저장될 수 없고, 그 대신에 분해되어 세포의 주요 대사 경로에 대한 중간체로 제공된다 [자세한 것은 문헌 (Stryer, L. Biochemistry 3rd ed. Ch. 21 "Amino Acid Degradation and the Urea Cycle" p. 495-516 (1988))을 참조함]. 세포가 불필요한 아미노산을 유용한 대사 중간체로 전환시킬 수 있다 하더라도, 아미노산 생성은 에너지, 전구체 분자, 및 이들 아미노산을 합성하는 데 필요한 효소를 고려할 때 손실이 큰 합성이다. 따라서, 특정한 아미노산의 존재가 그 자신의 생성을 서서히 또는 완전히 중지시키는 피드백 억제에 의해 아미노산의 생합성이 조절된다는 것은 놀라운 일이 아니다 [아미노산 생합성 경로의 피드백 기작에 대한 전체적인 내용은 문헌 (Stryer, L. Biochemistry 3rd ed. Ch. 24 "Biosynthesis of Amino Acids and Heme" p. 575-600 (1988))을 참조함]. 따라서, 임의의 특정 아미노산의 산출량은 세포에 존재하는 아미노산의 양에 의해 제한된다.
B. 비타민, 보조인자 및 영양제의 대사 및 용도
비타민, 보조인자 및 영양제는 박테리아와 같은 다른 생물체에 의해 쉽게 합성된다 하더라도 고등동물이 합성 능력을 상실하여 섭취해야 하는 분자의 또 다른 군을 구성한다. 이들 분자는 그 자체가 생활성 물질이거나, 다양한 대사 경로에서 전자 캐리어 또는 중간체로 작용할 수 있는 생물학적 활성 물질의 전구체이다. 이들의 영양 가치 이외에, 이들 화합물은 색소, 항산화제 및 촉매로서, 또는 다른 과정의 보조제로서 상당한 산업적 가치를 갖는다 (이들 화합물의 구조, 활성 및 산업적인 용도에 대한 것은 예컨대, 문헌 (Ullman's Encyclopedia of Industrial Chemistry, "Vitamins" vol. A27, p. 443-613, VCH: Weinheim, 1996)을 참조함]. 용어 "비타민"은 당업계에 인지되어 있고, 생물의 정상적인 기능을 위해서는 필요하지만 생물이 스스로 합성할 수 없는 영양분을 포함한다. 비타민 군은 보조인자 및 영양제 화합물도 포함할 수 있다. 용어 "보조인자"는 정상적인 효소 활성이 일어나는 데 필요한 비단백질원성 화합물을 포함한다. 이러한 화합물은 유기성 또는 무기성일 수 있고, 본 발명의 보조인자 분자는 유기성인 것이 바람직하다. 용어 "영양제"는 식물 및 동물, 특히 인간에게 건강상 유익한 식이성 보충물을 포함한다. 이러한 분자의 예로는 비타민, 항산화제 및 일부 지질 (예를 들어, 다불포화 지방산)이 있다.
이들을 생성할 수 있는 생물체, 예컨대, 박테리아에서 일어나는 이들 분자의 생합성의 특징은 잘 규명되어 있다 (Ullman's Encyclopedia of Industrial Chemistry, "Vitamins" vol. A27, p. 443-613, VCH: Weinheim, 1996; Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley & Sons; Ong, A. S., Niki, E. & Packer, L. (1995) "Nutrition, Lipids, Health, and Disease "Proceedings of the UNESCO/Confederation of Scientific and Technological Associations in Malaysia, and the Society for Free Radical Research-Asia, held Sept. 1-3, 1994 at Penang, Malaysia, AOCS Press: Champaign, IL X, 374 S).
티아민 (비타민 B1)은 피리미딘과 티아졸 잔기의 화학적 커플링에 의해 생성된다. 리보플라빈 (비타민 B2)는 구아노신-5'-트리포스페이트 (GTP) 및 리보스-5'-포스페이트로부터 합성된다. 그 다음, 리보플라빈은 플라빈 모노뉴클레오티드 (FMN) 및 플라빈 아데닌 디뉴클레오티드 (FAD)의 합성에 사용된다. 총칭하여 "비타민 B6"로 불리는 화합물 족 (예를 들어, 피리독신, 피리독사민, 피리독사-5'-포스페이트 및 시판되는 피리독신 히드로클로라이드)은 모두 통상적인 구조 단위인 5- 히드록시-6-메틸피리딘의 유도체이다. 판토테네이트 (판토텐산, (R)-(+)-N-(2,4-디히드록시-3,3-디메틸-1-옥소부틸)-β-알라닌)은 화학적인 합성 또는 발효에 의해 생성될 수 있다. 판토테네이트의 생합성의 최종 단계는 β-알라닌과 판토산의 ATP-유도 축합으로 구성된다. 판토산으로 전환하는 생합성 단계, β-알라닌으로 전환하는 생합성 단계 및 판토텐산으로의 축합에 관여하는 효소는 공지되어 있다. 판토테네이트의 대사 활성 형태는 보조효소 A인데, 이 보조효소 A를 위한 생합성은 5 단계 효소 반응으로 진행된다. 판토테네이트, 피리독살-5'-포스페이트, 시스테인 및 ATP는 보조효소 A의 전구체이다. 이들 효소는 판토테네이트의 형성을 촉매할 뿐만 아니라 (R)-판토산, (R)-판토락톤, (R)-판테놀 (프로비타민 B5), 판테테인 (및 그의 유도체) 및 보조효소 A의 생성도 촉매한다.
미생물에서 전구체 분자인 피멜로일-CoA로부터 바이오틴이 생합성되는 것은 자세히 연구되어 있고 관련된 여러가지 유전자가 확인되어 있다. 상응하는 다수의 단백질이 Fe-클러스터 합성에도 관여하는 것으로 밝혀져 있고 이들 단백질은 nifS 클래스 단백질의 구성원이다. 리포산은 옥타노산으로부터 유도되고, 에너지 대사에서 보조효소로 작용하는데, 상기 리포산은 에너지 대사에서 피루베이트 데히드로게나제 결합체 및 α-케토글루타레이트 데히드로게나제 결합체의 일부가 된다. 폴레이트는 모두 폴산의 유도체 물질의 군이고, 폴산은 L-글루탐산, p-아미노-벤조산 및 6-메틸프테린으로부터 유도된다. 대사 중간체인 구아노신-5'-트리포스페이트 (GTP), L-글루탐산 및 p-아미노-벤조산으로부터 출발하는, 폴산 및 그의 유도체의 생합성은 일부 미생물에서 상세히 연구되어 있다.
코리노이드 (예컨대, 코발라민 및 특히 비타민 B12) 및 포피린은 테트라피롤 고리계에 의해 특징지워지는 화학물질의 군에 속한다. 비타민 B12의 생합성은 그 특징이 완전히 규명되어 있지는 않지만 다수의 효소 및 기질이 현재 공지되어 있다는 점에서 충분히 복잡하다. 니코틴산 (니코티네이트) 및 니코틴아미드는 "니아신"으로도 불리는 피리딘 유도체이다. 니아신은 중요한 보조효소인 NAD (니코틴아미드 아데닌 디뉴클레오티드), NADP (니코틴아미드 아데닌 디뉴클레오티드 포스페이트) 및 그들의 환원형의 전구체이다.
이들 화합물의 대량 생산은 비록 이들 화학물질 중 일부, 예를 들어, 리보플라빈, 비타민 B6, 판토테네이트 및 바이오틴이 미생물의 대량 배양에 의해서도 생산된다 하더라도 세포-유리 화학 합성에 주로 의존한다. 비타민 B12만이 발효에 의해 전적으로 생성되는데, 이는 비타민 B12의 합성의 복잡성 때문이다. 시험관내 방법론은 재료 및 시간, 종종 많은 비용의 상당한 투입을 요구한다.
C. 퓨린, 피리미딘, 뉴클레오시드 및 뉴클레오티드의 대사 및 용도
퓨린 및 피리미딘 대사 유전자 및 이들의 상응하는 단백질은 종양 질환 및 바이러스 감염의 치료에 중요한 표적이다. 용어 "퓨린" 또는 "피리미딘"은 핵산, 보조효소 및 뉴클레오티드의 구성 성분인 질소 함유 염기를 포함한다. 용어 "뉴클레오티드"는 질소 함유 염기, 오탄당 (RNA의 경우, 상기 당은 리보스이고; DNA의 경우, 상기 당은 D-데옥시리보스임) 및 인산으로 구성된, 핵산 분자의 기본 구조 단위를 포함한다. 용어 "뉴클레오시드"는 뉴클레오티드의 전구체로 작용하지만 뉴클레오티드가 갖는 인산 잔기가 없는 분자를 포함한다. 이들 분자의 생합성을 억제하거나 핵산 분자를 형성하기 위한 이들 분자의 동원을 억제함으로써, RNA 및 DNA 합성을 억제하는 것이 가능하고; 암세포에 표적화시키는 방식으로 상기 활성을 억제함으로써 종양 세포의 분열 및 복제 능력을 억제할 수 있다. 또한, 핵산 분자를 형성하기 보다는 에너지 저장물(즉, AMP) 또는 보조효소 (즉, FAD 및 NAD)로 작용하는 뉴클레오티드도 있다.
이들 화학물질이 퓨린 및(또는) 피리미딘 대사에 영향을 줌으로써 상기 의학적 증상에 사용될 수 있다는 것은 여러 가지 문헌에 기재되어 있다 (예를 들어, Christopherson, R. I. and Lyons, S. D. (1990) "Potent inhibitors of de novo pyrimidine and purine biosynthesis as chemotherapeutic agents. "Med. Res. Reviews 10: 505-548). 퓨린 및 피리미딘 대사에 관여하는 효소의 연구는 예를 들어, 면역억제제 또는 항증식제로 사용할 수 있는 신약의 개발에 초점을 두고 있다 (Smith, J. L., (1995) "Enzymes in nucleotide synthesis." Curr. Opin. Struct. Biol. 5: 752-757; (1995) Biochem Soc. Transact. 23: 877-902). 그러나, 퓨린 및 피리미딘 염기, 뉴클레오시드 및 뉴클레오티드는 여러 가지 정밀 화학물질 (예를 들어, 티아민, S-아데노실-메티오닌, 폴레이트 또는 리보플라빈)의 생합성에 있어서 중간체로서의 용도, 세포를 위한 에너지 캐리어 (예를 들어, ATP 또는 GTP)로서의 용도, 및 통상적으로 향 상승제 (예를 들어, IMP 또는 GMP)로 사용되는 화학 물질 자체를 위한 용도 또는 여러 가지 의학 용도를 갖는다 [예를 들어, 문헌 (, Kuninaka, A. (1996) Nucleotides and Related Compounds in Biotechnology vol. 6, Rehm et al., eds. VCH: Weinheim, p. 561612)을 참조함]. 또한, 퓨린, 피리미딘, 뉴클레오시드 또는 뉴클레오티드 대사에 관여하는 효소를 표적으로 사용하여 살진균제, 제초제 및 살충제를 비롯한, 농작물 보호용 화학물질을 개발하는 연구가 증가하고 있다.
박테리아에 있어서 이들 화합물의 대사의 특징은 규명되어 있다 (예를 들어, 자세한 내용은 문헌 (Zalkin, H. and Dixon, J. E. (1992)" de novo purine nucleotide biosynthesis", in: Progress in Nucleic Acid Research and Molecular Biology, vol. 42, Academic Press:, p. 259-287; and Michal, G. (1999) "Nucleotides and Nucleosides", Chapter 8 in: Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, Wiley: New York)을 참조함). 퓨린의 대사는 집중적인 연구의 대상이고, 세포의 정상적인 기능에 필수적이다. 고등 동물의 손상된 퓨린 대사는 통풍과 같은 심각한 질환을 초래할 수 있다. 퓨린 뉴클레오티드는 구아노신-5'-모노포스페이트 (GMP) 또는 아데노신-5'-모노포스페이트 (AMP)를 생성시키는 중간체 화합물인 이노신-5'-포스페이트 (IMP)를 통해 일련의 단계에서 리보스-5-포스페이트로부터 합성되고, 이들 GMP 또는 AMP로부터 뉴클레오티드로 사용되는 트리포스페이트가 용이하게 형성된다. 이들 화합물은 에너지 저장물로도 사용되므로, 이들의 분해는 세포에서 다수의 다양한 생합성 과정을 위한 에너지를 공급한다. 피리미딘 생합성은 리보스-5-포스페이트로부터의 유리딘-5'- 모노포스페이트 (UMP)의 형성에 의해 진행된다. 그 다음, UMP가 시티딘-5'-트리포스페이트 (CTP)로 전환된다. 이들 모든 뉴클레오티드의 디옥시 형태는 뉴클레오티드의 디포스페이트 리보스 형태가 뉴클레오티드의 디포스페이트 데옥시리보스 형태로 전환되는 1 단계 환원 반응에서 생성된다. 인산화시, 이들 분자는 DNA 합성에 관여할 수 있다.
D.
트레할로스의
대사 및 용도
트레할로스는 α,α-1,1 결합에 의해 결합된 두 가지 당 분자로 구성된다. 트레할로스는 감미료, 건조 또는 동결 식품용 첨가제로서 식품 산업, 및 음료 산업에 통상적으로 사용된다. 그러나, 제약, 화장품 및 생물공학 산업에도 사용된다 [예를 들어, 문헌 (Nishimoto et al., (1998) 미국 특허 제5,759,610호; Singer, M. A. and Lindquist, S. (1998) Trends Biotech. 16: 460467; Paiva, C. L. A. and Panek, A. D. (1996) Biotech. Ann. Rev. 2: 293-314; and Shiosaka, M. (1997) J. Japan 172: 97-10)을 참조함]. 트레할로스는 다수의 미생물로부터 효소에 의해 생성되고 주위 배지내로 자연적으로 방출되는데, 트레할로스는 당업계에 공지된 방법을 이용하여 상기 배지로부터 수득할 수 있다.
II
. 막 생합성 및
막횡단
운반
세포막은 세포에서 다양한 기능을 수행한다. 첫째, 세포막은 세포 함유물을 주변 환경으로부터 분리시키며, 따라서 세포에 일체성을 부여한다. 막은 또한 위험성이거나 또는 원치 않는 화합물의 유입뿐 아니라 목적하는 화합물의 유출에 대한 장벽으로 작용할 수도 있다. 세포막은 본래, 극성 헤드 기가 외부를 향하고 있 고(각각 세포의 외부 및 내부를 향해) 비극성 테일이 이층의 중심으로 내부를 향하고 있어서 소수성 코어를 형성하는 그의 구조로 인해 단백질과 같은 소수성 화합물, 물 분자 및 이온의 비촉진성 확산에 대해 불투과성이다(일반적으로, 막 구조 및 기능의 조사를 위해서는, 문헌(Gennis, R. B. (1989) Biomembranes, Molecular Structure and Function, Springer: Heidelberg)을 참조한다). 이 장벽은 세포가 주변 매질내에 포함되어 있는 것보다 목적하는 화합물은 더 높은 농도로 유지하고 원치 않는 화합물은 상대적으로 더 낮은 농도로 유지할 수 있게 만드는데, 이는 이들 화합물의 확산이 막에 의해 효과적으로 차단되기 때문이다. 그러나, 막은 또한 목적 화합물의 유입 및 폐 분자의 배출에 대한 효과적인 장벽으로도 존재한다. 이러한 곤란함을 극복하기 위해, 세포막은 막을 여러 종류의 화합물의 막횡단 운반을 촉진시킬 수 있는 많은 종류의 운반체 단백질을 포함하고 있다. 이러한 운반 단백질로는 포어 또는 채널 및 운반체의 두가지 일반적인 종류가 있다. 포어 또는 채널은 전체 막 단배질, 때로는 단백질 복합체로서, 막을 통하여 조절성 구멍을 형성한다. 이러한 조절 또는 '게이팅'은 일반적으로 포어 또는 채널에 의해 운반될 분자에 대해 특이적(이 막횡단 구조물은 특정 종류의 기질에 대해 선택적으로 투과성이 됨)이며, 예를 들어, 칼륨 채널은 유사한 전하 및 크기를 갖는 이온 만이 통과할 수 있도록 구성된다. 채널 및 포어 단백질은, 이 단백질의 소수성 면이 막의 내부와 결합하는 반면 친수성 면은 채널의 내부에 늘어서 있음으로 인해 선택된 친수성 분자가 통과할 수 있는 보호된 친수성 환경을 제공하도록, 분리된 소수성 및 친수성 도메인을 갖는 경향이 있다. 칼륨, 칼슘, 나트륨 및 클로라이드 이온에 대 한 것을 비롯하여 이러한 많은 포어/채널이 당업계에 공지되어 있다.
촉진성 확산에 대한 상기의 포어 및 채널-매개 시스템은 이온과 같은 매우 작은 분자에 한정되는데, 이는 촉진성 확산에 의해 전체 단백질을 통과시키기에 충분한 크기의 포어 또는 채널이 더 작은 친수성 분자의 통과를 막을 수는 없기 때문이다. 이러한 과정에 의한 분자의 운반은 농도 구배의 동력이 필요하기 때문에 '촉진성 확산'이라고 때때로 표현한다. 투과효소는 또한, 글루코스 또는 기타 당의 농도가 세포의 한 측면에서 다른 측면보다 더 큰 경우, 세포내로 이들과 같은 더 큰 분자의 촉진성 확산(또한 '유니포트(uniport)'라고도 함)을 허용한다. 포어 또는 채널과는 대조적으로, 이러한 전체 막 단백질 (종종 막횡단 α-나선을 6 내지 14개 가짐)은 막을 통해 열린 채널을 형성하기보다는 막의 표면에서 표적 분자와 결합하고, 이어서 표적 분자가 막의 반대 측면으로 방출되도록 형태적 변화를 수행한다.
그러나, 세포는 흔히 촉진성 확산이 일어날 수 없는 상황에서 존재하는 농도 구배에 거슬러 분자의 유입 또는 유출('능동 수송')시켜야 할 필요가 있다. 이러한 막 운반에 대하여 세포에 의해 이용되는 두가지 일반적인 메카니즘, 즉 심포트 또는 안티포트, 및 ABC 운반체에 의해 매개되는 것과 같은 에너지-연계성 운반이 있다. 심포트 및 안티포트 시스템은 막을 가로질러 두가지 다른 분자의 이동을 연결시키는데(두가지 다른 분자에 대한 두가지 별도의 결합 부위를 갖는 투과효소를 통해); 심포트에서는, 두 분자가 같은 방향으로 운반되지만, 안티포트에서는 한 분자는 유입되고 다른 분자는 유출된다. 에너지면에서, 이러한 운반은 두 분자 중 하나가 농도 구배에 따라 이동하기 때문에 가능한 것이며, 에너지면에서 유리한 이 작용은 우세한 농도 구배에 거슬러 목적하는 화합물을 동시에 이동시키는 경우에만 허용된다. 단일 분자는 ABC 운반체에 의해 이용되는 것과 같은 에너지-추진 과정에서 농도 구배에 거슬러 막을 통해 운반될 수 있다. 이 시스템에서, 막에 위치하는 운반 단백질은 ATP-결합 카세트를 갖는데, 표적 분자가 결합하게 되면, ATP는 ADP + Pi로 전환되고, 그로 인해 방출된 에너지가 이용됨으로써 운반체에 의해 촉진되는 막의 반대 측면으로의 표적 분자의 이동을 추진시킨다. 이러한 운반 시스템 모두에 대한 보다 상세한 설명으로는 문헌[Bamberg, E. et al., (1993)"Charge transport of ion pumps on lipid bilayer membranes", Q. Rev. Biophys. 26: 1-25; Findlay, J. B. C. (1991)"Structure and function in membrane transport systems", Curr. Opin. Struct. Biol. 1: 804-810; Higgins, C. F. (1992)"ABC transporters from microorganisms to man", Ann. Rev. Cell Biol. 8: 67-113; Gennis, R. B. (1989)"Pores, Channels and Transporters", in: Biomembranes, Molecular Structure and Function, Springer: Heidelberg, p. 270-322; and Nikaido, H. and Saier, H. (1992) "Transport proteins in bacteria: common themes in their design", Science 258: 936-942] 및 이들 문헌 각각에 포함된 참고 문헌을 참조한다.
막의 합성은 많은 성분을 포함하는 잘 확립된 과정이며, 이들 성분 중 가장 중요한 것은 지질 분자이다. 지질 합성은 두 부분, 즉 지방산의 합성 및 지방산의 sn-글리세롤-3-포스페이트로의 부착, 및 극성 헤드 기의 부가 또는 변형으로 구분 될 수 있다. 박테리아 막에서 이용되는 전형적인 지질로는 인지질, 당지질, 스핑고지질 및 포스포글리세라이드가 포함된다. 지방산 합성은 아세틸 CoA가 각각 아세틸 CoA 카르복실라제에 의해 말로닐 CoA로, 아세틸트랜스아실라제에 의해 아세틸-ACP로 전환됨으로써 시작된다. 축합 반응에 이어서, 이들 두 생성물 분자는 함께 아세토아세틸-ACP를 형성하며, 이는 일련의 축합, 환원 및 탈수 반응에 의해 전환되어 목적하는 쇄 길이를 갖는 포화 지방산 분자를 생성한다. 이러한 분자로부터 불포화 지방산의 생성은 특정 불포화효소에 의해 산소 분자의 도움으로 호기적 또는 혐기적으로 촉진된다[지방산 합성에 대한 참고문헌으로는 문헌[F. C. Neidhardt et al. (1996) E. coli and Salmonella. ASM Press: Washington, D. C., p. 612-636 and references contained therein; Lengeler et al. (eds) (1999) Biology of Procaryotes. Thieme: Stuttgart, New York, and references contained therein; and Magnuson, K. et al., (1993) Microbiological Reviews 57: 522-542] 및 이들 문헌에 포함된 참고문헌을 참조한다]. 시클로프로판 지방산(CFA)은 기질로서 SAM을 사용하여 특정 CFA-신타제에 의해 합성된다. 분지쇄 지방산은 탈아민하되어 분지쇄 2-옥소-산을 생성하는 분지쇄 아미노산으로부터 합성된다[문헌[Lengeler et al., eds. (1999) Biology of Procaryotes. Thieme: Stuttgart, New York] 및 이 문헌에 포함된 참고문헌을 참조한다]. 지질 합성에서 다른 필수적인 단계는, 예를 들어, 글리세롤-포스페이트-아실트랜스퍼라제에 의한 극성 헤드 기 상으로의 지방산의 전이이다. 다양한 전구체 분자 및 생합성 효소를 병용하여 막의 조성에 큰 영향을 미치는 여러 지방산 분자를 생성한다.
III
. 본 발명의 요소 및 방법
본 발명은, 부분적으로는, 코리네박테리움 글루타미쿰에서 세포막 형성을 조절하며 이 막을 통한 분자의 이동을 조절하는, 본원에서 MCT 핵산 및 단백질 분자로 언급되는 새로운 분자의 발견을 기초로 한다. 한 실시양태에서, MCT 분자는 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 및 이 막을 통한 분자의 운반에 관여한다. 바람직한 실시양태에서, 막 성분의 생산 및 막 운반을 조절하는 본 발명의 MCT 분자의 활성은 이 생물에 의한 목적하는 정밀 화학물질의 생산에 영향을 준다. 특히 바람직한 실시양태에서, 본 발명의 MCT 단백질이 조절하는 코리네박테리움 글루타미쿰 대사 경로가 수율, 생산 및(또는) 생산 효율면에서 조절되고, 막을 통한 화합물의 운반 효율이 변경되어, 코리네박테리움 글루타미쿰에 의해 목적하는 정밀 화학물질 생산의 수율, 생산 및(또는) 생산 효율이 직접적 또는 간접적으로 조절되도록 본 발명의 MCT 분자의 활성을 조절한다.
용어 "MCT 단백질" 또는 "MCT 폴리펩티드"에는 코리네박테리움 글루타미쿰 세포막의 구성에 필요한 화합물의 대사, 또는 이 막을 통한 분자의 운반에 관여하는 단백질이 포함된다. MCT 단백질의 예에는 표 1에 기재된 MCT 유전자 및 홀수 서열 번호의 서열에 의해 코딩되는 것들이 포함된다. 용어 "MCT 유전자" 또는 "MCT 핵산 서열"에는 코딩 영역 및 이에 대응하는 번역되지 않는 5' 및 3' 서열 영역으로 이루어진, MCT 단백질을 코딩하는 핵산 서열이 포함된다. MCT 유전자의 예로는 표 1에 기재된 것들이 포함된다. 용어 "생산" 또는 "생산성"은 당업계에서 인식되는 용어이며, 소정의 시간 및 소정의 발효 용적내에서 형성되는 발효 생성물 의 농도(예를 들어, 1시간에 1리터 당 kg 생성물)가 포함된다. 용어 "생산 효율"에는 특정 생성물 농도를 달성하는데 요구되는 시간(예를 들어, 세포가 특정 비율의 정밀 화학물질 생성물을 얻는데 걸리는 시간)이 포함된다. 용어 "수율" 또는 "생성물/탄소 수율"은 당업계에서 인식되는 용어이며, 탄소 공급원의 생성물(즉, 정밀 화학물질)로의 전환 효율이 포함된다. 이 용어는 일반적으로는, 예를 들어, 탄소 공급원 kg 당 생성물 kg으로 표기된다. 화합물의 수율 또는 생산율을 증대시킴으로써, 소정의 시간 동안 얻어지는 수득량의 배양물 중 이 화합물의 회수된 분자의 양 또는 유용한 분자의 양은 증가하게 된다. 용어 "생합성" 또는 "생합성 경로"는 당업계에서 인식되는 용어이고, 세포에 의한 중간체 화합물로부터의 화합물, 바람직하게는 유기 화합물의 합성을 포함하며, 다단계의 고도로 조절되는 과정일 수 있다. 용어 "분해" 또는 "분해 경로"는 당업계에서 인식되는 용어이고, 세포에 의한 화합물, 바람직하게는 유기 화합물의 분해 생성물(일반적으로 말해서, 더 작거나 덜 복잡한 구조의 분자)로의 분해를 포함하며, 다단계의 고도로 조절되는 과정일 수 있다. 이어서, 특정 화합물의 대사(예를 들어, 글리신 등의 아미노산의 대사)에는 이러한 화합물과 관련되는 세포의 전체 생합성, 변형, 및 분해 경로가 포함된다.
또다른 실시양태에서, 본 발명의 MCT 분자는 코리네박테리움 글루타미쿰과 같은 미생물에서 정밀 화학물질 등의 목적하는 분자의 생산을 조절할 수 있다. 본 발명의 MCT 분자의 변형이 변형된 단백질을 혼입하는 코리네박테리움 글루타미쿰 균주로부터 정밀 화학물질 생산의 수율, 생산율 및(또는) 생산 효율에 직접 영향을 줄 수 있는 다수의 메카니즘이 있다. 세포로부터의 정밀 화학물질 분자의 배출에 관여하는 이러한 MCT 단백질을, 이러한 화합물이 보다 쉽게 회수되는 세포외 매질로 더 많은 양이 분비되도록, 그의 수 또는 활성을 증가시킬 수 있다. 마찬가지로, 1종 이상의 정밀 화학물질(예를 들어, 포스페이트, 술페이트 질소 화합물 등)의 생합성에 필요한 영양분의 유입에 관여하는 MCT 단백질을, 이러한 전구체, 보조인자 또는 중간체 화합물의 세포내 농도가 증가되도록, 그의 수 또는 활성을 증가시킬 수 있다. 또한, 지방산 및 지질 자체는 바람직한 정밀 화학물질이며, 이러한 화합물의 생합성에 관여하는 1종 이상의 본 발명의 MCT 단백질의 활성을 최적화하거나 또는 그의 수를 증가시킴으로써, 또는 이러한 화합물의 분해에 관여하는 1종 이상의 MCT 단백질의 활성을 손상시킴으로써, 코리네박테리움 글루타미쿰으로부터 지방산 및 지질 분자의 수율, 생산 및(또는) 생산 효율을 증가시킬 수 있다.
본 발명의 1종 이상의 MCT 유전자의 돌연변이유발에 의해 코리네박테리움 글루타미쿰으로부터 1종 이상의 목적하는 정밀 화학물질의 생산에 직접적으로 영향을 주는, 변화된 활성을 갖는 MCT 단백질을 생성시킬 수도 있다. 예를 들어, 폐 생성물의 배출에 관여하는 본 발명의 MCT 단백질을, 세포의 정상적인 대사성 폐기물(목적하는 정밀 화학물질의 과다생산으로 인해 양이 증가될 수 있음)이 세포내에서 뉴클레오티드 및 단백질을 손상시키거나(세포의 생존율이 감소됨) 또는 정밀 화학물질 생합성 경로를 방해하기(목적하는 정밀 화학물질의 수율, 생산 또는 생산 효율이 저하됨) 전에 효과적으로 배출되도록, 그의 수 또는 활성을 증가시킬 수 있다. 또한, 세포내에서 비교적 다량인 정밀 화학물질은 그 자체로도 세포에 독성을 띨 수 있어서, 세로로부터 이 화합물을 배출시킬 수 있는 운반자의 활성 또는 수를 증가시킴으로써, 배양물내 세포의 생존율을 증가시킬 수 있고, 다시 말하면, 배양물내에서 목적하는 정밀 화학물질을 생산하는 세포수를 더 증가시킬 수 있다. 적절한 양의 다른 지질 및 지방산 분자가 생산되도록 본 발명의 MCT 단백질을 조작할 수도 있다. 이는 세포막의 지질 조성에 중요한 영향을 줄 수 있다. 각 지질 타입은 다른 물리적 특성을 가지기 때문에, 막의 지질 조성에 있어서의 변화는 막의 유동성을 상당히 변화시킬 수 있다. 막 유동성에서의 변화는 막을 통한 분자의 운반성뿐 아니라 세포의 일체성에 영향을 줄 수 있으며, 이들 둘 다는 대규모 발효 배양에서 코리네박테리움 글루타미쿰으로부터 정밀 화학물질의 생산에 상당한 영항을 준다.
본 발명의 단리된 핵산 서열은 명칭이 ATCC13032로 부여된, 아메리칸 타입 컬쳐 콜렉션에서 분양받을 수 있는 코리네박테리움 글루타미쿰 균주의 게놈내에 포함되어 있다. 단리된 코리네박테리움 글루타미쿰 MCT DNA의 뉴클레오티드 서열 및 코리네박테리움 글루타미쿰 MCT 단백질의 예상 아미노산 서열은 각각 서열 목록에 홀수 서열 번호 및 짝수 서열 번호로 나타나 있다. 이러한 뉴클레오티드 서열을, 세포막 성분의 대사에 관여하는 단백질 또는 이 막을 통한 화합물의 운반에 관여하는 단백질을 코딩하는 서열로서 분류 및(또는) 확인하는 컴퓨터 분석을 수행하였다.
본 발명은 또한 본 발명의 아미노산 서열(예를 들어, 서열 목록의 짝수 서열 번호의 서열)과 실제적으로 상동성인 아미노산 서열을 갖는 단백질에 관한 것이다. 본원에 사용된 바와 같이, 선택되는 아미노산 서열과 실제적으로 상동성인 아미노산 서열을 갖는 단백질은 선택되는 아미노산, 예를 들어, 선택되는 전체 아미노산 서열에 대해 약 50% 이상의 상동성이 있다. 선택되는 아미노산 서열과 실제적으로 상동성인 아미노산 서열을 갖는 단백질은 선택되는 아미노산 서열에 대해 약 50 내지 60% 이상, 바람직하게는 약 60 내지 70% 이상, 보다 바람직하게는 약 70 내지 80%, 80 내지 90%, 또는 90 내지 95% 이상, 가장 바람직하게는 약 96% 이상, 97% 이상, 98% 이상, 99% 이상의 상동성이 있다.
본 발명의 MCT 단백질 또는 그의 생물학적으로 활성인 부분 또는 단편은 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여하거나 또는 표 1에 기재된 활성을 한가지 이상 가질 수 있다.
본 발명의 다양한 측면은 하기 서브섹션에 보다 상세히 기재되어 있다.
A. 단리된 핵산 분자
본 발명의 한 측면은 MCT 폴레펩티드 또는 그의 생물학적으로 활성인 일부를 코딩하는 단리된 핵산 분자뿐 아니라 MCT-코딩 핵산(예를 들어, MCT DNA) 확인 또는 증폭을 위한 혼성화 프로브 또는 프라이머로 사용하기에 충분한 핵산 단편에 관한 것이다. 본원에 사용된 바와 같이, 용어 "핵산 분자"는 DNA 분자(예를 들어, cDNA 또는 게놈 DNA), RNA 분자(예를 들어, mRNA), 및 뉴클레오티드 유사체를 사용하여 생성되는 DNA 또는 RNA 유사체를 포함하는 의미이다. 이 용어에는 또한 유전자의 코딩 영역의 3' 및 5' 말단의 둘 다에 위치하는 비번역 서열, 코딩 영역의 5' 말단으로부터 상류의 약 100개 이상의 뉴클레오티드 서열, 및 이 유전자의 코딩 영역의 3' 말단으로부터 하류의 약 20개 이상의 뉴클레오티드 서열이 포함된다. 핵산 분자는 단일 가닥 또는 이중 가닥일 수 있으며, 바람직하게는 이중 가닥 DNA이다. "단리된" 핵산 분자는 핵산의 천연 공급원에 존재하는 다른 핵산 분자로부터 분리되는 것이다. 바람직하게는, "단리된" 핵산은 이 핵산이 유도되는 생물의 게놈 DNA에서 본래 핵산의 양측면에 있는 서열(즉, 핵산의 5' 및 3' 말단에 위치하는 서열)을 가지고 있지 않다. 예를 들어, 다양한 실시양태에서, 단리된 MCT 핵산 분자는 이 핵산이 유도되는 세포(예를 들어, 코리네박테리움 글루타미쿰 세포)의 게놈 DNA에서 본래 핵산 분자의 양측면에 있는 약 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb 또는 0.1 kb 보다 작은 크기의 뉴클레오티드 서열을 포함할 수 있다. 게다가, "단리된" 핵산 분자, 예를 들어, DNA 분자는, 재조합 기술에 의해 생산되는 경우 다른 세포 물질 또는 배양 배지, 또는 화학적으로 합성되는 경우 화학물질 전구체 또는 다른 화학물질을 실제적으로 함유하지 않는다.
표준 분자 생물학 기술 및 본원에 제공되는 서열 정보를 이용하여, 본 발명의 핵산 분자, 예를 들어, 서열 목록의 홀수 서열 번호의 뉴클레오티드 서열을 갖는 핵산 분자 또는 그의 일부를 단리할 수 있다. 예를 들어, 서열 목록의 홀수 서열 번호의 서열 중 하나의 전부 또는 일부를 혼성화 프로브로 사용하고 표준 혼성화 기술(예를 들어, 문헌[Sambrook, J., Fritsh, E.F., and Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989]에 기재된 바와 같은 혼성화 기술)을 사용하여 코리네박테리움 글루타미쿰 라이브러리로부터 코리네박테리움 글루타미쿰 MCT DNA를 단리할 수 있다. 더우기, 본 발명의 핵산 서열(예를 들어, 이와 동일한 서열을 기초로 하여 설계된 올리고뉴클레오티드 프라이머를 사용하는 중합효소 연쇄반응에 의해 본 발명의 핵산 서열(예를 들어, 서열 목록의 홀수 서열 번호의 서열) 중 하나의 전부 또는 일부를 포함하는 핵산 분자를 단리할 수 있음)을 기초로 하여 설계된 올리고뉴클레오티드 프라이머를 사용하는 중합효소 연쇄반응에 의해 본 발명의 핵산 서열(예를 들어, 홀수 서열 번호의 서열) 중 하나의 전부 또는 일부를 포함하는 핵산 분자를 단리할 수 있다. 예를 들어, mRNA는 정상 내피세포로부터 (예를 들어, 문헌[Chirgwin et al.(1979) Biochemistry 18:5294-5299]의 구아니디늄-티오시아네이트 추출 방법에 의해) 단리할 수 있고, DNA는 역전사효소(예를 들어, Gibco/BRL(Bethesda, MD)로부터 입수가능한 몰로네이(Moloney) MLV 역전사효소; 또는 세이까가꾸 아메리카, 인크.(Seikagaku America, Inc., St. Petersburg, FL)로부터 입수가능한 AMV 역전사효소)를 사용하여 제조할 수 있다. 서열 목록에 기재된 뉴클레오티드 서열 중 하나를 기초로 하여 중합효소 연쇄반응 증폭을 위한 합성 올리고뉴클레오티드 프라이머를 설계할 수 있다. 본 발명의 핵산은 cDNA 또는, 별법으로, 게놈 DNA를 주형으로 사용하고 표준 PCR 증폭 기술에 따라 적절한 올리고뉴클레오티드 프라이머를 사용하여 증폭시킬 수 있다. 이와 같이 증폭된 핵산을 적절한 벡터내에 클로닝하고 DNA 서열 분석에 의해 특성화할 수 있다. 또한, MCT 뉴클레오티드 서열에 상응하는 올리고뉴클레오티드는 표준 합성 기술, 예를 들어, 자동 DNA 합성기를 사용하여 제조할 수 있다.
바람직한 실시양태에서, 본 발명의 단리된 핵산 분자는 서열 목록에 기재된 뉴클레오티드 서열 중 하나를 포함한다. 서열 목록에 기재된 바와 같은 본 발명의 핵산 서열은 본 발명의 코리네박테리움 글루타미쿰 MCT DNA에 상응한다. 이 DNA는 MCT 단백질을 코딩하는 서열(즉, 서열 목록에서 홀수 서열 번호의 서열에 나타낸 "코딩 영역")뿐 아니라 서열 목록에서 각 홀수 서열 번호의 서열에 나타낸 5' 비번역 서열 및 3' 비번역 서열도 포함한다. 또는, 핵산 분자는 서열 목록의 핵산 서열 중 하나의 코딩 영역만을 포함할 수 있다.
본 출원의 목적을 위해, 서열 목록에 기재된 핵산 및 아미노산 서열 각각은 명칭 "RXA", "RXN", "RXS" 또는 "RXC"에 이어 5개의 숫자를 갖는 확인을 위한 RXA, RXN, RXS 또는 RXC 수(즉, RXA02099, RXN03097, RXS00148 또는 RXC01748)를 가지는 것으로 이해될 것이다. 핵산 서열 각각은 세 부분, 즉 5' 상류 영역, 코딩 영역 및 하류 영역으로 이루어져 있다. 혼란을 방지하기 위해, 이들 세 영역의 각각은 동일한 RXA, RXN, RXS 또는 RXC 명칭에 의해 확인된다. 이외에, "서열 목록의 홀수 서열 중 하나"는 서열 목록에서 핵산 서열 중 어떤 것을 의미하며, 또한 이들의 다른 RXA, RXN, RXS 또는 RXC 명칭에 의해 구별할 수도 있다. 이 서열 각각의 코딩 영역은 또한 서열 목록에 짝수 서열 번호로 기재되어 있는 대응 아미노산(대응 핵산 서열은 바로 밑에 기재되어 있음)으로 번역된다. 예를 들어, RXA03097에 대한 코딩 영역은 서열 1에 기재되어 있으며, 그가 코딩하는 아미노산 서열은 서열 2에 기재되어 있다. 본 발명의 핵산 분자의 서열은, 이들이 쉽게 상호관련될 수 있 도록, 이들이 코딩하는 아미노산 분자로서 동일한 RXA, RXN, RXS 또는 RXC 명칭에 의해 확인된다. 예를 들어, RXA02099, RXN03097, RXS00148 및 RXC01748로 명명된 아미노산 서열은 각각 핵산 분자 RXA02099, RXN03097, RXS00148 및 RXC01748의 뉴클레오티드 서열의 코딩 영역의 번역물이다. 본 발명의 RXA, RXN, RXS 및 RXC 뉴클레오티드 및 아미노산 서열과 이들의 배정된 서열 번호 사이의 대응관계는 표 1에 기재되어 있다. 예를 들어, 표 1에 기재된 바와 같이, RXA00104의 뉴클레오티드 서열은 서열 5에 나타나 있고, RXA00104의 아미노산 서열은 서열 6에 나타나 있다.
본 발명의 유전자들 중 몇몇은 "F-명칭 유전자"이다. F-명칭 유전자는 표 1에 기재된 유전자들을 포함하며, 이들은 RXA, RXN, RXS 또는 RXC 명칭 앞에 'F'를 갖는다. 예를 들어, 표 1에 나타낸 바와 같이, "F RXA02581"로 명명된 서열 11은 F-명칭 유전자이며, 서열 31, 33 및 43(표 1에서 각각 "F RXA02487", "F RXA02490" 및 "F RXA02809"로 명명됨)도 마찬가지이다.
한 실시양태에서, 본 발명의 핵산 분자는 표 2에 기재된 것들을 포함하지 않는다. dapD 유전자의 경우, 이 유전자에 대한 서열은 문헌[Wehrmann, A., et al, (1998) J. Bacteriol. 180(12):3159-3165]에 공개되어 있다. 그러나, 본 발명자들이 얻은 서열은 공개된 서열 형태 보다 상당히 더 길다. 공개된 서열 형태는 정확하지 않은 개시 코돈에 의존한 것이며, 따라서 실제 코딩 영역의 단편만을 나타낸 것이라고 생각된다.
바람직한 다른 실시양태에서, 본 발명의 단리된 핵산 분자는 본 발명의 뉴클 레오티드 서열(예를 들어, 서열 목록의 홀수 서열 번호의 서열) 중 하나의 보완물인 핵산 분자을 포함한다. 본 발명에 나타낸 뉴클레오티드 서열 중 하나에 대해 보완적인 핵산 분자는 서열 목록에 나타낸 뉴클레오티드 서열(예를 들어, 홀수 서열 번호의 서열) 중 하나에 대해 충분히 보완적인 것이어서, 그는 본 발명의 뉴클레오티드 서열 중 하나와 혼성화함으로써 안정한 이중쇄를 형성한다.
바람직한 또다른 실시양태에서, 본 발명의 단리된 핵산 분자는 본 발명의 뉴클레오티드 서열(예를 들어, 서열 목록의 홀수 서열 번호의 서열 중 한 서열)과 약 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59% 또는 60% 이상, 바람직하게는 약 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, 또는 70% 이상, 보다 바람직하게는 약 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 또는 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 또는 90%, 또는 91%, 92%, 93%, 94% 이상, 보다 더 바람직하게는 약 95%, 96%, 97%, 98%, 또는 99% 이상의 상동성이 있는 뉴클레오티드 서열 또는 그의 일부를 포함한다. 상기 언급된 범위에 대해 중간 정도의 범위 및 동일성 수치(예를 들어, 70 내지 90% 동일 또는 80 내지 95% 동일)는 본 발명에 포함되는 것이다. 예를 들어, 상기에서 상한치 및(또는) 하한치로 언급된 수치들 중 임의 조합을 이용한 동일성 수치 범위는 본 발명에 포함되는 것이다. 추가의 바람직한 실시양태에서, 본 발명의 단리된 핵산 분자는, 예를 들어 엄격 조건하에, 본 발명의 뉴클레오티드 서열 중 하나 또는 그의 일부와 혼성화하는 뉴클레오티드 서열을 포함한다.
게다가, 본 발명의 핵산 분자는 서열 목록의 홀수 서열 번호의 서열 중 한 서열의 코딩 영역의 일부만을, 예를 들어, 프로브 또는 프라이머로 사용될 수 있는 단편 또는 MCT 단백질의 생물학적으로 활성인 일부를 코딩하는 단편을 포함할 수 있다. 코리네박테리움 글루타미쿰으로부터의 MCT 유전자의 클로닝으로부터 결정되는 뉴클레오티드 서열을 이용하여 다른 유형의 세포 및 생물체에서 MCT 상동체뿐만 아니라 다른 코리네박테리아 또는 관련 종으로부터 MCT 상동체를 확인하고(하거나) 클로닝하는데 사용하기 위해 설계된 프로브 및 프라이머를 생성시킬 수 있다. 프로브/프라이머는 통상적으로 사실상 정제된 올리고뉴클레오티드를 포함한다. 올리고뉴클레오티드는 통상적으로 엄격 조건하에 본 발명의 뉴클레오티드 서열(예를 들어, 서열 목록의 홀수 서열 번호의 서열 중 하나) 중 하나의 센스 가닥, 이들 서열들 중 하나의 안티-센스 서열, 또는 자연 발생적인 그의 변이체의 약 12개, 바람직하게는 약 25개, 보다 바람직하게는 약 40, 50 또는 75개 이상의 연속된 뉴클레오티드와 혼성화하는 뉴클레오티드 서열 영역을 포함한다. 본 발명의 뉴클레오티드 서열을 기초로 한 프라이머는 MCT 상동체를 클로닝하기 위한 PCR 반응에서 사용될 수 있다. MCT 뉴클레오티드 서열을 기초로 한 프로브를 사용하여 동일하거나 상동성인 단백질을 코딩하는 전사체 또는 게놈 서열을 찾을 수 있다. 바람직한 실시양태에서, 프로브는 그에 부착되는 라벨 기를 추가로 포함하며, 예를 들어, 라벨 기는 방사성동위원소, 형광성 화합물, 효소 또는 효소 보조인자일 수 있다. 이러한 프로브는, 예를 들어 세포 시료 중 MCT-코딩 핵산 수준을 측정함으로써, 예를 들어 MCT mRNA 수준을 검출하거나 또는 게놈 MCT 유전자가 변이되었는지 또는 결실되었는지를 결정함으로써, MCT 단백질을 잘못 발현시키는 세포를 확인하기 위한 진단용 시험 키트의 일부로 사용될 수 있다.
한 실시양태에서, 본 발명의 핵산 분자는 본 발명의 아미노산 서열(예를 들어, 서열 목록의 짝수 서열 번호의 서열)과 충분히 상동성이 있는 아미노산 서열을 포함하는 단백질 또는 그의 일부를 코딩하며, 이 단백질 또는 그의 일부는 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여하는 능력을 유지한다. 본원에 사용된 바와 같이, 용어 "충분히 상동성인"이란 본 발명의 아미노산 서열에 대해 동일 또는 동등한 최소 수의 아미노산 잔기(예를 들어, 서열 목록의 짝수 번호 서열 중 하나의 서열에서의 하나의 아미노산 잔기와 유사한 측쇄를 갖는 아미노산 잔기)을 포함하는 아미노산 서열을 갖는 단백질 또는 그의 일부를 의미하며, 이 단백질 또는 그의 일부는 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여할 수 있다. 이러한 막 성분의 대사 경로 또는 막 운반 시스템의 단백질 구성원은, 본원에 기재된 바와 같이, 1종 이상의 정밀 화학물질의 생산 및 분비에서 작용할 수 있다. 이러한 활성의 예는 또한 본원에 기재되어 있다. 따라서, "MCT 단백질의 기능"은 1종 이상의 정밀 화학물질의 수율, 생산 및(또는) 생산 효율에 직접 또는 간접적으로 기여한다. MCT 단백질 활성의 예는 표 1에 기재되어 있다.
또다른 실시양태에서, 단백질은 본 발명의 전체 아미노산 서열(예를 들어, 서열 목록의 짝수 서열 번호의 서열)과 약 50% 내지 60% 이상, 바람직하게는 약 60% 내지 70% 이상, 보다 바람직하게는 약 70% 내지 80%, 80% 내지 90%, 90% 내지 95% 이상, 가장 바람직하게는 약 96%, 97%, 98% 또는 99% 이상의 상동성이 있다.
본 발명의 MCT 핵산 분자에 의해 코딩되는 단백질의 일부는 바람직하게는 MCT 단백질 중 하나의 생물학적으로 활성인 일부이다. 본원에 사용된 바와 같이, 용어 "MCT 단백질의 생물학적으로 활성인 일부"는 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여하거나 또는 표 1에 기재된 바와 같은 활성을 갖는 MCT 단백질의 일부, 예를 들어, 그의 도메인/모티프를 포함한다. MCT 단백질 또는 생물학적으로 활성인 그의 일부가 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여할 수 있는지를 결정하기 위해, 효소 활성의 분석을 수행할 수 있다. 이러한 분석 방법은, 실시예 8에 기재된 바와 같이, 당업계의 숙련인에게 잘 알려져 있다.
MCT 단백질의 생물학적으로 활성인 일부를 코딩하는 다른 핵산 단편은 MCT 단백질 또는 펩티드의 코딩 부분을 발현시키는(예를 들어, 시험관내에서 재조합 발현시킴으로써) 본 발명의 아미노산 서열(예를 들어, 서열 목록의 짝수 서열 번호의 서열) 중 하나의 일부를 단리하고, MCT 단백질 또는 펩티드의 코딩되는 부분의 활성을 평가함으로써 제조할 수 있다.
본 발명은, 본 발명에 나타낸 뉴클레오티드 서열(예를 들어, 서열 목록의 홀수 서열 번호의 서열) 중 하나와 상이하지만 유전자 코드의 축퇴성으로 인해 본 발명의 뉴클레오티드 서열에 의해 코딩되는 것과 동일한 MCT 단백질을 코딩하는 핵산 분자(및 그의 단편)를 포함한다. 또다른 실시양태에서, 본 발명의 단리된 핵산 분 자는 서열 목록에 나타낸 아미노산 서열(예를 들어, 짝수 서열 번호의 서열)을 갖는 단백질을 코딩하는 뉴클레오티드 서열을 갖는다. 또다른 실시양태에서, 본 발명의 핵산 분자는 본 발명의 아미노산 서열(서열 목록의 홀수 서열 번호의 서열에 나타낸 오픈 리딩 프레임에 의해 코딩됨)과 실제적으로 상동성인 전장의 코리네박테리움 글루타미쿰 단백질을 코딩한다.
당업자라면, 한 실시양태에서 본 발명의 서열이 본 발명의 이전에 이용가능했던, 표 2 또는 4에 기재된 진뱅크(Genbank) 서열과 같은 선행 기술의 서열을 포함하는 것이 아님을 알 것이다. 한 실시양태에서, 본 발명은 선행 기술의 서열(예를 들어, 표 2 또는 4에 기재된 진뱅크 서열(또는 이러한 서열에 의해 코딩되는 단백질))보다 더 큰 본 발명의 뉴클레오티드 또는 아미노산 서열과 동일성(%)을 갖는 뉴클레오티드 서열 및 아미노산 서열을 포함한다. 예를 들어, 본 발명은 RXA01420(서열 7)로 명명되는 뉴클레오티드 서열보다 더 크고(크거나) 그와 38% 이상의 동일성을 갖는 뉴클레오티드 서열, RXA00104(서열 5)로 명명되는 뉴클레오티드 서열보다 더 크고(크거나) 그와 43% 이상의 동일성이 있는 뉴클레오티드 서열 및 RXA02173(서열 25)로 명명되는 뉴클레오티드 서열보다 더 크고(크거나) 그와 45% 이상의 동일성이 있는 뉴클레오티드 서열이 포함된다. 당업자라면, 주어진 서열에 대한 3개의 최고 히트 각각에 대해 표 4에 나타낸 GAP-계산된 동일성(%) 점수를 조사하고, GAP-계산된 가장 높은 동일성(%)를 100에서 차감하여 본 발명의 임의 주어진 서열에 대한 동일성(%)의 하한 역치를 계산할 수 있을 것이다. 당업자라면 또한 이렇게 계산된 하한 역치보다 더 큰 동일성(%)(예를 들어, 약 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59% 또는 60% 이상, 바람직하게는 약 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, 또는 70% 이상, 보다 바람직하게는 약 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 또는 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 또는 90%, 또는 91%, 92%, 93%, 94% 이상, 보다 더 바람직하게는 약 95%, 96%, 97%, 98%, 또는 99% 이상의 동일성)을 갖는 핵산 서열 및 아미노산 서열이 본 발명에 포함됨을 알 것이다.
당업자라면, 서열 목록에서 홀수 서열 번호로 기재된 코리네박테리움 글루타미쿰 MCT 뉴클레오티드 서열 이외에도, MCT 단백질의 아미노산 서열에서의 변화를 초래하는 DNA 서열의 다형성이 집단(예를 들어, 코리네박테리움 글루타미쿰 집단)내에 존재할 수 있음을 알 것이다. MCT 유전자에 있어서의 이러한 유전적 다형성은 자연적인 변화로 인해 집단내의 개체들 사이에 존재할 수 있다. 본원에 사용된 바와 같이, 용어 "유전자" 및 "재조합 유전자"는 MCT 단백질, 바람직하게는 코리네박테리움 글루타미쿰 MCT 단백질을 코딩하는 오픈 리딩 프레임을 포함하는 핵산 분자를 의미한다. 이러한 자연적인 변화는 통상적으로는 MCT 유전자의 뉴클레오티드 서열을 1 내지 5% 변화시킨다. 자연적인 변화의 결과이며 MCT 단백질의 기능적 활성을 변화시키지 않는, MCT 유전자의 임의 및 모든 이러한 뉴클레오티드 변화 및 그에 따라 나타난 아미노산의 다형성은 본 발명의 범위내이다.
천연 변이체 및 본 발명의 코리네박테리움 글루타미쿰 MCT DNA의 비-코리네박테리움 글루타미쿰 상동체에 대응하는 핵산 분자는, 본원에 개시된 코리네박테리움 글루타미쿰 MCT 핵산에 대한 이들의 상동성에 기초하여, 엄격 혼성화 조건하에 표준 혼성화 기술에 따라 혼성화 프로브로서 코리네박테리움 글루타미쿰 DNA 또는 그의 일부를 사용하여 단리할 수 있다. 따라서, 또다른 실시양태에서, 본 발명의 단리된 핵산 분자는 뉴클레오티드 15개 이상의 길이이며, 엄격 조건하에 서열 목록의 홀수 서열 번호의 뉴클레오티드 서열을 포함하는 핵산 분자와 혼성화한다. 다른 실시양태에서, 핵산은 뉴클레오티드 30개, 50개, 100개 또는 250개 이상의 길이이다. 본원에 사용된 바와 같이, 용어 "엄격 조건하에 혼성화하는"은 서로에 대해 통상적으로 60% 이상의 상동성인 뉴클레오티드 서열이 서로 혼성화된 채로 남아 있는, 혼성화 및 세척을 위한 조건을 설명하는 의미이다. 바람직하게는, 이 조건은 서로에 대해 통상적으로 약 65% 이상, 보다 바람직하게는 약 70% 이상, 보다 더 바람직하게는 약 75% 이상 상동성인 서열이 서로에 대해 혼성화된 채로 남아 있는 조건이다. 이러한 엄격 조건은 당업계의 숙련인에게 잘 알려져 있으며, 문헌[Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (1989), 6.3.1-6.3.6]에서 찾을 수 있다. 엄격 혼성화 조건에 대한 바람직한 비제한적 실시예는 약 45 ℃에서 6 ×염화나트륨/시트르산나트륨(SSC) 중의 혼성화 이후에 50 내지 65 ℃에서 0.2 ×SSC, 0.1% SDS 중의 1회 이상의 세척이다. 바람직하게는, 엄격 조건하에 본 발명의 뉴클레오티드 서열과 혼성화하는 본 발명의 단리된 핵산 분자는 자연 발생적인 핵산 분자에 상응한다. 본원에 사용된 바와 같이, "자연 발생적인" 핵산 분자는 자연에 존재하는(예를 들어, 천연 단백질을 코딩하는) 뉴클레오티드 서열을 갖는 RNA 또는 DNA 분자를 의미한다. 한 실시양태에서, 핵산은 천연 코리네박테리움 글루타미쿰 MCT 단백질을 코딩한다.
집단내에 존재할 수 있는 MCT 서열의 자연 발생적인 변이체 이외에도, 당업자라면 또한 본 발명의 뉴클레오티드 서열내의 변이에 의해, MCT 단백질의 기능성을 변화시키지 않고, 코딩된 MCT 단백질의 아미노산 서열에서 변화를 일으킴으로써 변화를 도입할 수 있음을 알 것이다. 예를 들어, "비필수" 아미노산 잔기에서 아미노산 치환을 일으키는 뉴클레오티드 치환이 본 발명의 뉴클레오티드 서열에서 일어날 수 있다. "비필수 아미노산" 잔기가 상기 MCT 단백질의 활성을 변화시키지 않으면서 MCT 단백질(예를 들어, 서열 목록의 짝수 서열 번호의 서열) 중 하나의 야생형 서열로부터 변화될 수 있는 잔기인 반면 "필수" 아미노산 잔기는 MCT 단백질 활성에 요구된다. 그러나, 다른 아미노산 잔기(예를 들어, MCT 활성을 갖는 도메인에서 보존되지 않거나 또는 반보존된 잔기)는 활성에 필요하지 않을 수도 있으며, 따라서 MCT 활성을 변화시키지 않으면서도 변화시킬 수 있다.
따라서, 본 발명의 또다른 측면은 MCT 활성에 필수적이지 않은 아미노산 잔기에서의 변화를 포함하는 MCT 단백질을 코딩하는 핵산 분자에 관한 것이다. 이러한 MCT 단백질은 서열 목록에서 짝수 서열 번호의 서열로부터의 아미노산 서열이 다르며, 본원에 기재된 MCT 활성 중 적어도 하나를 보유한다. 한 실시양태에서, 단리된 핵산 분자는, 본 발명의 아미노산 서열과 약 50% 이상 상동성인 아미노산 서열을 포함하며, 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여할 수 있거나, 또는 표 1에 기재된 바와 같은 활성을 1가지 이상 갖는 단백질을 코딩하는 뉴클레오티드 서열을 포함한다. 바람직하게는, 핵산 분자에 의해 코딩되는 단백질은 서열 목록의 홀수 서열 번호의 서열 중 하나의 아미노산 서열에 대해 약 50 내지 60% 이상, 보다 바람직하게는 이러한 서열 중 하나에 대해 약 60 내지 70% 이상, 보다 더 바람직하게는 이러한 서열 중 하나에 대해 약 70 내지 80%, 80 내지 90%, 90 내지 95% 이상, 가장 바람직하게는 본 발명의 아미노산 서열 중 하나에 대해 약 96%, 97%, 98% 또는 99% 이상 상동성이 있다.
두 아미노산 서열(예를 들어, 본 발명의 아미노산 서열 중 하나 및 그의 변이체 형태) 또는 두 핵산 서열의 상동성(%)을 결정하기 위해, 최적의 비교 목적을 위해 서열을 정렬시킨다(예를 들어, 다른 단백질 또는 핵산과의 최적의 정렬을 위해 하나의 단백질 또는 핵산의 서열내에 갭을 도입시킬 수 있다). 이어서, 아미노산 위치 또는 뉴클레오티드 위치에 대응하는 아미노산 잔기 또는 뉴클레오티드를 비교한다. 한 서열(예를 들어, 본 발명의 아미노산 서열 중 하나)내의 위치가 다른 서열(예를 들어, 아미노산 서열의 변이체 형태)내의 상응하는 위치와 동일한 아미노산 잔기 또는 뉴클레오티드에 의해 점유되는 경우, 분자는 그 위치에서 상동성이 있는 것이다(즉, 본원에 사용된 바와 같이, 아미노산 또는 핵산의 "상동성"은 아미노산 또는 핵산의 "동일성"과 동등한 의미이다). 두 서열 사이의 상동성(%)은 서열들에 의해 공유되는 동일한 위치의 개수의 함수이다(즉, 상동성(%) = 동일한 위치의 개수/위치의 총 개수 ×100).
코딩되는 단백질내에 하나 이상의 아미노산의 치환, 부가 또는 결실이 도입되도록 본 발명의 뉴클레오티드 서열내에 하나 이상의 뉴클레오티드의 치환, 부가 또는 결실을 도입시킴으로써, 본 발명의 단백질 서열(예를 들어, 서열 목록의 짝수 서열 번호의 서열)과 상동성인 MCT 단백질을 코딩하는 단리된 핵산 분자를 생성시킬 수 있다. 부위-지시적 돌연변이유발법 및 PCR-매개 돌연변이유발법과 같은 표준 기술에 의해 본 발명의 뉴클레오티드 서열들 중 하나에 변이를 도입할 수 있다. 바람직하게는, 예상되는 하나 이상의 비필수 아미노산 잔기에서 보존된 아미노산 치환을 수행할 수 있다. "보존된 아미노산 치환"이란 아미노산 잔기가 유사한 측쇄를 갖는 아미노산 잔기로 대체되는 것을 말한다. 유사한 측쇄를 갖는 아미노산 잔기의 군은 당업계에 정의되어 있다. 이러한 군에는 염기성 측쇄를 갖는 아미노산(예를 들어, 라이신, 아르기닌, 히스티딘), 산성 측쇄를 갖는 아미노산(예를 들어, 아스파라긴산, 글루탐산), 비하전된 극성 측쇄를 갖는 아미노산(예를 들어, 글리신, 아스파라긴, 글루타민, 세린, 트레오닌, 티로신, 시스테인), 비극성 측쇄를 갖는 아미노산(예를 들어, 알라닌, 발린, 루이신, 이소루이신, 프롤린, 페닐알라닌, 메티오닌, 트립토판), 베타-분지 측쇄를 갖는 아미노산(예를 들어, 트레오닌, 발린, 이소루이신) 및 방향족 측쇄를 갖는 아미노산(예를 들어, 티로신, 페닐알라닌, 트립토판, 히스티딘)이 포함된다. 따라서, MCT 단백질에서 예상되는 비필수 아미노산 잔기는 바람직하게는 동일한 측쇄 군으로부터의 다른 아미노산 잔기로 치환된다. 또는, 또다른 실시양태에서, 변이는, 예를 들어, 포화 돌연변이유발법에 의해 MCT 코딩 서열의 전부 또는 일부를 따라 무작위적으로 도입될 수 있으며, MCT 활성을 보유하는 변이체를 확인하기 위해, 생성된 변이체를 본원에 기재된 MCT 활성에 대하여 스크리닝 할 수 있다. 서열 목록의 홀수 서열 번호의 서열들 중 한 뉴클레오티드 서열을 돌연변이유발시킨 다음, 코딩된 단백질을 재조합적으로 발현 시킬 수 있고, 예를 들어 본원에 기재된 분석법을 이용하여 단백질의 활성을 결정할 수 있다(실시예 8을 참조).
상기 기재된 MCT 단백질을 코딩하는 핵산 분자 이외에, 본 발명의 다른 측면은 그와 안티센스인 단리된 핵산 분자에 관한 것이다. "안티센스" 핵산은 단백질을 코딩하는 "센스" 핵산에 상보적인, 예를 들어 이중쇄 cDNA 분자의 코딩 가닥에 대해 상보적인 또는 mRNA 서열에 대해 상보적인 뉴클레오티드 서열을 포함한다. 따라서, 안티센스 핵산은 센스 핵산과 수소 결합할 수 있다. 안티센스 핵산은 전체 MCT 코딩 가닥과 또는 그의 일부에만 상보적일 수 있다. 한 실시양태에서, 안티센스 핵산 분자는 MCT 단백질을 코딩하는 뉴클레오티드 서열의 코딩 가닥의 "코딩 영역"에 대해 안티센스이다. 용어 "코딩 영역"은 아미노산 잔기로 번역되는 코돈을 포함하는 뉴클레오티드 서열의 영역(예를 들어, 서열 5(RXA00104)의 전체 코딩 영역은 뉴클레오티드 1에서 756을 포함함)을 의미한다. 또다른 실시양태에서, 안티센스 핵산 분자는 MCT를 코딩하는 뉴클레오티드 서열의 코딩 가닥의 "비코딩 영역"에 대해 안티센스이다. 용어 "비코딩 영역"은 아미노산으로 번역되지 않는, 코딩 영역의 양측에 있는 5' 및 3' 서열(즉, 5' 및 3' 비번역 영역이라고도 함)을 의미한다.
본원에 개시된 MCT를 코딩하는 코딩 가닥 서열(예를 들어, 이 서열은 서열 목록에서 홀수 서열 번호로 기재되어 있음)을 기초로 하여, 왓슨(Watson)과 크릭(Crick)의 염기쌍 규칙에 따라 본 발명의 안티센스 핵산을 설계할 수 있다. 이 안티센스 핵산 분자는 MCT mRNA의 전체 코딩 영역에 대해 상보적일 수 있지만, 보다 바람직하게는 MCT mRNA의 코딩 또는 비코딩 영역의 일부에만 안티센스인 올리고뉴클레오티드이다. 예를 들어, 안티센스 올리고뉴클레오티드는 MCT mRNA의 번역 개시 부위 주변의 영역에 대해 상보적일 수 있다. 안티센스 올리고뉴클레오티드는, 예를 들어, 뉴클레오티드 약 5, 10, 15, 20, 25, 30, 35, 40, 45 또는 50개 길이이다. 본 발명의 안티센스 핵산은 당업계에 공지된 방법을 이용하는 화학적 합성법 및 효소적 라이게이션 반응법을 이용하여 작제할 수 있다. 예를 들어, 자연 발생적인 뉴클레오티드, 또는 분자의 생물학적 안정성을 증가시키거나 또는 안티센스와 센스 핵산 사이에 형성된 이중쇄의 물리적인 안정성을 증가시키기 위해 설계된 다양하게 변형된 뉴클레오티드를 사용하여(예를 들어, 포스포로티오에이트 유도체 및 아크리딘 치환된 뉴클레오티드가 사용될 수 있음), 안티센스 핵산(예를 들어, 안티센스 올리고뉴클레오티드)을 화학적으로 합성할 수 있다. 안티센스 핵산을 생성하는데 사용될 수 있는 변형된 뉴클레오티드의 예로는 5-플루오로우라실, 5-브로모우라실, 5-클로로우라실, 5-요오도우라실, 하이포크산틴, 크산틴, 4-아세틸시토신, 5-(카르복시히드록실메틸)우라실, 5-카르복시메틸아미노메틸-2-티오우리딘, 5-카르복시메틸아미노메틸우라실, 디히드로우라실, 베타-D-갈락토실퀘오신, 이노신, N6-이소펜테닐아데닌, 1-메틸구아닌, 1-메틸이노신, 2,2-디메틸구아닌, 2-메틸아데닌, 2-메틸구아닌, 3-메틸시토신, 5-메틸시토신, N6-아데닌, 7-메틸구아닌, 5-메틸아미노메틸우라실, 5-메톡시아미노메틸-2-티오우라실, 베타-D-만노실퀘오신, 5'-메톡시카르복시메틸우라실, 5-메톡시우라실, 2-메틸티오-N6-이소펜테닐아데닌, 우라실-5-옥시아세트산(v), 비부톡소신, 슈도우라실, 퀘오신, 2-티오시토신, 5-메틸-2-티오 우라실, 2-티오우라실, 4-티오우라실, 5-메틸우라실, 우라실-5-옥시아세트산, 메틸에스테르, 우라실-5-옥시아세트산(v), 5-메틸-2-티오우라실, 3-(3-아미노-3-N-2-카르복시프로필)우라실, (acp3)w 및 2,6-디아미노퓨린이 포함된다. 또는, 핵산이 안티센스 방향으로 서브클로닝된 발현 벡터(즉, 삽입된 핵산으로부터 전사되는 RNA는 목적하는 표적 핵산에 대해 안티센스 방향임. 하기 서브섹션에 추가로 설명되어 있음)를 사용하여 안티센스 핵산을 생물학적으로 생성시킬 수 있다.
본 발명의 안티센스 핵산 분자는 통상적으로 세포에 투여되거나 또는 이들이 MCT 단백질을 코딩하는 세포의 mRNA 및(또는) 게놈 DNA와 혼성화하거나 또는 그와 결합함으로써, 예를 들어 전사 및(또는) 번역을 저해함으로써, 단백질의 발현을 억제하도록 반응계내에서 생성된다. 혼성화는 안정한 이중쇄를 형성하는 통상의 뉴클레오티드 상보성에 의한 것이거나 또는, 예를 들어, 이중 나선의 메이저 그루브에서 특이적 상호작용을 통해 DNA 이중쇄와 결합하는 안티센스 핵산 분자의 경우에 의한 것일 수 있다. 안티센스 분자는, 예를 들어 안티센스 핵산 분자를 세포 표면의 수용체 또는 항원과 결합하는 펩티드 또는 항체에 연결시킴으로써, 그가 선택된 세포 표면에서 발현되는 수용체 또는 항원과 특이적으로 결합하도록 변형시킬 수 있다. 또한, 본원에 기재된 벡터를 사용하여 안티센스 핵산 분자를 세포에 전달시킬 수도 있다. 안티센스 분자의 충분한 세포내 농도를 달성하기 위해서는, 안티센스 핵산 분자가 강력한 원핵세포, 바이러스 또는 진핵세포 프로모터의 조절하에 놓여 있는 벡터 구조물이 바람직하다.
또다른 실시양태에서, 본 발명의 안티센스 핵산 분자는 α-아노머 핵산 분자 이다. α-아노머 핵산 분자는 상보적 RNA와 특이적 이중 가닥 하이브리드를 형성하며, 이 때 통상의 β-유닛과는 대조적으로, 가닥들은 서로에 대해 평행한 상태로 있다(Gaultier et al.(1987) Nucleic Acids. Res. 15:6625-6641). 안티센스 핵산 분자는 2'-o-메틸리보뉴클레오티드(Inoue et al. (1987) Nucleic Acids Res. 15:6131-6148) 또는 키메라 RNA-DNA 유사체(Inoue et al.(1987) FEBS Lett. 215:327-330)를 포함할 수도 있다.
또다른 실시양태에서, 본 발명의 안티센스 핵산 분자는 라이보자임이다. 라이보자임은 리보뉴클레아제 활성을 갖는 촉매성 RNA 분자이며, 그와 상보적 영역을 갖는 mRNA 등의 단일 가닥 핵산을 절단할 수 있다. 따라서, 라이보자임(예를 들어, 햄머헤드(hammerhead) 라이보자임(문헌[Haselhoff and Gerlach (1988) Nature 334:585-591]에 기재되어 있음))을 사용하여 MCT mRNA 전사체를 촉매적으로 절단함으로써 MCT mRNA의 번역을 억제할 수 있다. 본원에 개시된 MCT DNA의 뉴클레오티드 서열(즉, 서열 5(RXA00104))을 기초로 하여 MCT-코딩 핵산에 대해 특이성을 갖는 라이보자임을 설계할 수 있다. 예를 들어, 테트라히메나(Tetrahymena) L-19 IVS RNA의 유도체를 제작할 수 있으며, 여기서 활성 부위의 뉴클레오티드 서열은 MCT-코딩 mRNA에서 절단되는 뉴클레오티드 서열에 대해 상보적이다[예를 들어, 세치(Cech) 등의 미국 특허 제4,987,071호 및 세치(Cech) 등의 미국 특허 제5,116,742호를 참조]. 또는, MCT mRNA를 사용하여 RNA 분자의 푸울로부터 특정 리보뉴클레아제 활성을 갖는 촉매성 RNA를 선별해낼 수 있다[예를 들어, 문헌[Bartel, D. and Szostak, J.W.(1993) Science 261:1411-1418]을 참조].
또는, MCT 뉴클레오티드 서열의 조절 영역(예를 들어, MCT 프로모터 및(또는) 인핸서)에 대해 상보적인 뉴클레오티드 서열을 표적화하여 표적 세포에서 MCT 유전자의 전사를 방지하는 삼중 나선 구조를 형성시킴으로써 MCT 유전자의 발현을 억제시킬 수 있다[일반적으로, 문헌[Helene, C.(1991) Anticancer Drug Des. 6(6):569-84; Helene, C. et al. (1992) Ann.N.Y. Acad.Sci.660:27-36; and Maher, L.J. (1992) Bioassays 14(12):807-15]을 참조].
B. 재조합 발현 벡터 및 숙주 세포
본 발명의 다른 측면은 벡터, 바람직하게는 MCT 단백질 (또는 그의 일부)을 코딩하는 핵산을 함유하는 발현 벡터에 관한 것이다. 본원에서 사용된 바와 같이, 용어 "벡터"란 그에 연결된 다른 핵산을 수송할 수 있는 핵산을 지칭한다. 벡터의 한 유형으로 "플라스미드"란 추가의 DNA 절편이 라이게이션될 수 있는 환형 이중 가닥 DNA 고리를 의미한다. 벡터의 다른 유형인 바이러스 벡터는 추가의 DNA 절편을 바이러스 게놈 내로 라이게이션시킬 수 있다. 특정 벡터는 도입된 숙주 세포 내에서 자율적으로 복제될 수 있다 (예를 들면, 박테리아 복제 기점을 가진 박테리아 벡터 및 포유류의 에피솜 벡터). 다른 벡터 (예를 들면, 포유류의 비-에피솜 벡터)는 숙주 세포 내로 도입된 후 숙주 게놈 내로 통합되어 숙주 게놈을 따라 함께 복제된다. 또한, 특정 벡터는 작동가능하게 연결된 유전자의 발현을 지시할 수 있다. 본 명세서에서는 그러한 벡터를 "발현 벡터"로 언급한다. 일반적으로, 재조합 DNA 기술에서 사용하는 발현 벡터는 대개 플라스미드의 형태를 갖는다. 플라스미드는 가장 일반적으로 사용되는 벡터 형태이기 때문에, 본 명세서에서는 "플라 스미드"와 "벡터"를 혼용할 수 있다. 그러나, 본 발명에는 동등한 기능을 제공하는 바이러스 벡터 (예를 들면, 복제 결손 레트로바이러스, 아데노 바이러스 및 아데노-관련 바이러스)와 같은 다른 형태의 발현 벡터도 포함된다.
본 발명의 재조합 발현 벡터는 본 발명의 핵산을 숙주 세포 내에서 핵산의 발현에 적합한 형태로 포함하며, 적합한 형태란 상기 재조합 발현 벡터가 발현용 숙주 세포를 기준으로 선택된 하나 이상의 조절 서열 (발현되는 핵산 서열에 작동가능하게 연결됨)을 함유하고 있음을 의미한다. 재조합 발현 벡터 내에서, "작동가능하게 연결된"이란, 원하는 뉴클레오티드 서열이 (예를 들면, 시험관내 전사/번역 시스템 내 또는 벡터가 숙주 세포 내로 도입되는 경우 숙주 세포 내에서) 발현가능하도록 조절 서열(들)에 연결된 것을 의미한다. 용어 "조절 서열"이란, 프로모터, 인핸서 및 기타 발현 조절 요소 (예를 들면, 폴리아데닐화 신호)를 포함하는 것으로 한다. 그러한 조절 서열은, 예를 들어 문헌 [Goeddel; Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, CA (1990)]에 기술되어 있다. 조절 서열에는 다수의 숙주 세포 유형 내에서 뉴클레오티드 서열이 구성적으로 발현되도록 하는 것과 특정 숙주 세포 내에서만 뉴클레오티드 서열이 발현되도록 하는 것이 포함된다. 바람직한 조절 서열에는, 예를 들어 박테리아에서 바람직하게 사용되는 cos-, tac-, trp-, tet-, trp-tet-, lpp-, lac-, lpp-lac-, lacIq-, T7-, T5-, T3-, gal-, trc-, ara-, SP6-, arny, SPO2, λ-PR- 또는 λPL와 같은 프로모터가 있다. 추가의 조절 서열에는, 예를 들어 ADC1, MFα, AC, P-60, CYC1, GAPDH, TEF, rp28, ADH와 같은 효모 및 진균으로부터의 프로모터, CaMV/35S, SSU, OCS, lib4, usp, STLS1, B33, nos나 유비퀴틴- 또는 파세올린-프로모터와 같은 식물로부터의 프로모터가 있다. 또한 인공 프로모터도 사용할 수 있다. 당업자는 발현 벡터가 형질전환되는 숙주 세포의 선택, 목적 단백질의 발현 정도 등과 같은 인자들에 따라 다르게 고안될 수 있음을 이해할 것이다. 본 발명의 발현 벡터는 숙주세포에 도입됨으로써 본 명세서에 기술된 핵산에 의해 코딩되는 융합 단백질 또는 펩티드 (예를 들면, MCT 단백질, MCT 단백질의 돌연변이 형태, 융합 단백질 등)를 비롯한 단백질 또는 펩티드를 생산할 수 있다.
본 발명의 재조합 발현 벡터는 원핵 또는 진핵 세포에서의 MCT 단백질 발현용으로 고안될 수 있다. 예를 들어, MCT 유전자는 코리네박테리움 글루타미쿰과 같은 박테리아 세포, 곤충 세포 (바쿨로바이러스 발현 벡터 사용), 효모 및 다른 진균류 세포 (문헌 [Romanos, M.A. et al. (1992) "Foreign gene expression in yeast: a review", Yeast 8:423-488; van den Hondel, C.A.M.J.J. et al. (1991) "Heterologous gene expression in filamentous fungi" in: More Gene Manipulations in Fungi, J.W. Bennet & L.L. Lasure, eds., p.396-428: Academic Press: San Diego; and van den Hondel, C.A.M.J.J. & Punt, P.J. (1991) "Gene transfer systems and vector development for filamentous fungi, in: Applied Molecular Genetics of Fungi, Peberdy, J.F. et al., eds., p. 1-28, Cambridge University Press: Cambridge] 참조), 조류 및 다세포 식물 세포 (문헌 [Schmidt, R. and Willmitzer, L. (1988) High efficiency Agrobacterium tumefactiens- mediated transformation of Arabidopsis thaliana leaf and cotyledon explants" Plant Cell Rep.:583-586] 참조) 또는 포유류 세포 내에서 발현될 수 있다. 적합한 숙주 세포는 문헌 [Goeddel, Gene Expression Technology : Methods in Enzymology 185, Academic Press, San Diego, CA (1990)]에 더 기술되어 있다. 별법으로, 예를 들어 T7 프로모터 조절 서열 및 T7 중합효소를 사용하여 재조합 발현 벡터를 시험관 내에서 전사 및 번역시킬 수 있다.
원핵 세포 내에서의 단백질 발현은 대체로 융합 또는 비-융합 단백질의 발현을 지시하는 구성적 또는 유도가능한 프로모터 함유 벡터로 수행한다. 융합 벡터는 그의 코딩되는 단백질에, 일반적으로는 재조합 단백질의 아미노 말단 뿐 아니라 C-말단에 다수의 아미노산을 부가하거나, 그 단백질의 적절한 영역 내에서 다수의 아미노산을 융합시킨다. 그러한 융합 벡터는 전형적으로 다음의 세 가지 목적, 1) 재조합 단백질의 발현 증가, 2) 재조합 단백질의 가용성 증가, 및 3) 친화성 정제에서 리간드로서 작용함에 의한 재조합 단백질 정제 상의 용이함을 위한 것이다. 대개 융합 발현 벡터 내에서는 융합 부분과 재조합 단백질의 접합부에 단백질 절단 부위가 도입되어 있어서 융합 단백질을 정제한 후 융합 부분으로부터 재조합 단백질을 분리할 수 있다. 그러한 효소 및 그의 동족 인식 서열에는 응고인자 Xa, 트롬빈 및 엔테로키나제 등이 있다.
전형적인 융합 발현 벡터에는 pGEX (Pharmacia Biotech Inc; 문헌 [Smith, D.B. and Johnson, K.S. (1988) Gene 67:31-40] 참조), pMAL (New England Biolabs, Beverly, MA) 및 pRIT5 (Pharmacia, Piscataway, NJ) 등이 있으며, 이들 은 각각 글루타티온-S-트랜스퍼라제 (GST), 말토스 E 결합 단백질 또는 프로틴 A (protein A)를 표적 재조합 단백질에 융합시킨다. 한 실시양태에서는 MCT 단백질의 코딩 서열을 pGEX 발현 벡터 내로 클로닝하여 N-말단 내지 C-말단에 GST-트롬빈 절단 부위-X 단백질을 함유하는 융합 단백질 코딩 벡터를 생성하였다. 상기 융합 단백질은 글루타티온-아가로스 수지를 사용하는 친화도 크로마토그래피에 의해 정제할 수 있다. GST에 융합되지 않은 재조합 MCT 단백질은 융합 단백질을 트롬빈으로 절단함으로써 얻을 수 있다.
적합한 유도가능한 비-융합 대장균 발현 벡터의 예로는 pTrc (문헌 [Amann et al.,(1988) Gene 69:301-315] 참조), pLG338, pACYC184, pBR322, pUC18, pUC19, pKC30, pRep4, pHS1, pHS2, pPLc236, pMBL24, pLG200, pUR290, pINIII113-B1, λgt11, pBdCl 및 pET 11d (문헌 [Studier et al., Gene Expression Technology : Methods in Enzymology 185, Academic Press, San Diego, California (1990) 60-89] 및 문헌 [Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018] 참조)가 있다. pTrc 벡터에서 표적 유전자는 trp-lac 혼성 융합 프로모터로부터 숙주 RNA 폴리머라제의 전사에 의해 발현된다. pET 11d 벡터에서 표적 유전자는 T7 gn 10-lac 융합 프로모터로부터 동시 발현된 바이러스 RNA 폴리머라제 (T7 gn1)가 매개하는 전사에 의해 발현된다. 이 바이러스 폴리머라제는 숙주 균주 BL21(DE3) 또는 HMS174(DE3)에 존재하는, lacUV 5 프로모터의 전사 조절 하에 T7 gn1 유전자를 함유하는 λ프로파지로부터 공급된다. 다양한 박테리아의 형질전환을 위해 적절한 벡터를 선택할 수 있다. 예를 들어, 플라스미드 pIJ101, pIJ364, pIJ702 및 pIJ361은 스트렙토마이세스 (Streptomyces)를 형질전환시키는데 유용한 것으로 알려진 반면, 플라스미드 pUB110, pC194 또는 pBD214는 바실루스 (Bacillus) 종을 형질전환시키는데 적합하다. 코리네박테리움 내로 유전 정보를 전달하는데 사용되는 플라스미드에는 pHM1519, pBL1, pSA77 또는 pAJ667 (문헌 [Pouwels et al.,eds.(1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018] 참조) 등이 있다.
재조합 단백질의 발현을 극대화하는 한가지 전략은 재조합 단백질에 대한 단백질 분해성 절단력이 손상된 숙주 박테리아 내에서 상기 단백질을 발현시키는 것이다 (문헌 [Gottesman, S., Gene Expression Technology : Methods in Enzymology 185, Academic Press, San Diego, California (1990) 119-128] 참조). 다른 전략으로는 발현 벡터 내로 삽입되는 핵산의 핵산 서열을 변형하여 각각의 아미노산에 대한 개별적인 코돈이 발현을 위해 선택된 박테리아 (예를 들어, 코리네박테리움 글루타미쿰 글루타미쿰)가 선호하는 코돈이 되도록 하는 것이 있다 (문헌 [Wada et al.(1992) Nucleic Acids Res. 20:2111-2118] 참조). 이처럼 본 발명의 핵산 서열의 변형은 표준 DNA 합성 기술에 의해 수행될 수 있다.
다른 실시양태에서, MCT 단백질 발현 벡터는 효모 발현 벡터이다. 효모 사카로마이세스 세레비지애 (Saccharomyces cerevisiae)의 발현 벡터의 예로는 pYepSec1 (문헌 [Baldari, et al.,(1987) Embo J.6:229-234), 2μ, pAG-1, Yep6, Yep13, pEMBLYe23, pMFa (문헌 [Kurjan and Herskowitz,(1982) Cell 30:933-943) 참조), pJRY88 (문헌 [Shultz et al.,(1987) Gene 54:113-123] 참조) 및 pYES2 (Invitrogen Corporation, San Diego, CA) 등이 있다. 사상 진균류와 같은 다른 진균류용으로 적절한 벡터 및 벡터의 제조 방법으로는 문헌 [van den Hondel, C.A.M.J.J. & Punt, P.J. (1991) "Gene transfer systems and vector development for filamentous fungi, in:Applied Molecular Genetics of Fungi, J.F. Peberdy, et al.,eds., p. 1-28, Cambridge University Press: Cambridge] 및 문헌 [Pouwels et al.,eds.(1985) Cloning Vectors. Elsevier: New York (IBSN 0 444 904018)]에 상술된 것들이 포함된다.
별법으로, 바쿨로바이러스 발현 벡터를 사용하여 본 발명의 MCT 단백질을 곤충 세포 내에서 발현시킬 수 있다. 배양된 곤충 세포 (예를 들면, Sf 9 세포)에서의 단백질 발현용 바쿨로바이러스 벡터에는 pAc계 (문헌 [Smith et al. (1983) Mol. Cell Biol. 3:2156-2165] 참조) 및 pVL계 (문헌 [Lucklow and Summers (1989) Virology 170:31-39] 참조) 등이 있다.
다른 실시양태에서는 단세포 식물 세포 (예를 들어, 조류) 또는 고등 식물 (예를 들면, 작물 식물과 같은 종자 식물)로부터의 식물 세포 내에서 본 발명의 MCT 단백질을 발현시킬 수 있다. 식물 발현 벡터의 예로는 문헌 [Becker, D., Kemper, E., Schell, J. and Masterson, R. (1992) "New plant binary vectors with selectable markers located proximal to the left border", Plant Mol . Biol. 20: 1195-1197], 문헌 [Bevan, M.W. (1984) "Binary Agrobacterium vectors for plant transformation", Nucl . Acid . Res. 12: 8711-8721]에 상술된 것들이 포함되며 pLGV23, pGHlac+, pBIN19, pAK2004 및 pDH51 (문헌 [Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018] 참조)가 포함된다.
또 다른 실시양태에서는 포유류 발현 벡터를 사용하여 포유류 세포 내에서 본 발명의 핵산을 발현시킨다. 포유류 발현 벡터의 예로는 pCDM8 (문헌 [Seed, B. (1987) Nature 329:840] 참조) 및 pMT2PC (문헌 [Kaufman et al. (1987) EMBO J. 6:187-195] 참조) 등이 있다. 포유류 세포를 사용하는 경우, 발현 벡터의 조절 기능은 대개 바이러스 조절 요소에 의한 것이다. 예를 들어, 일반적으로 사용되는 프로모터는 폴리오마, 아데노바이러스 2, 사이토메갈로바이러스 및 시미안 바이러스 40으로부터 유래된 것이다. 원핵 세포 및 진핵 세포 둘 다에 적합한 다른 발현계에 대해서는 문헌 [Chapters 16 and 17 of Sambrook, J., Fritsh, E.F., and Maniatis, T. Molecular Cloning: A Laboratory Manual . 2 nd . ed . Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989]을 참조한다.
다른 실시양태에서, 재조합 포유류 발현 벡터는 특정 세포 유형에서의 차별적인 핵산 발현이 가능하도록 한다 (예를 들면, 조직-특이적 조절 요소가 핵산을 발현시키는데 사용된다). 조직-특이적 조절 요소는 당업계에 공지되어 있다. 적합한 조직-특이적 프로모터의 예로는 알부민 프로모터 (간-특이적; 문헌 [Pinkert et al. (1987) Genes Dev. 1:268-277] 참조), 림프양-특이적 프로모터 (문헌 [Calame and Eaton (1988) Adv . Immunol. 43:235-275] 참조), 특히 T 세포 수용체의 프로모터 (문헌 [Winoto and Baltimore (1989) EMBO J. 8:729-733] 참조)와 면역글로불린의 프로모터 (문헌 [Banerji et al. (1983) Cell 33:729-740], 문헌 [Queen and Baltimore (1983) Cell 33:741-748] 참조), 뉴런-특이적 프로모터 (예를 들면, 뉴로필라멘트 프로모터; 문헌 [Byrne and Ruddle (1989) PNAS 86:5473-5477] 참조), 췌장-특이적 프로모터 (문헌 [Edlund et al. (1985) Science 230:912-916] 참조) 및 유선(乳腺)-특이적 프로모터 (예를 들면, 유장(乳漿) 프로모터; 미국 특허 제4,873,316호 및 유럽 출원 번호 제264,166호 참조) 등이 있으나, 이에 제한되지 않는다. 또한, 발생-조절 프로모터, 예를 들어 쥐과 hox 프로모터 (문헌 [Kessel and Gruss (1990) Science 249:374-379] 참조) 및 α-페토프로틴 프로모터 (문헌 [Campes and Tilghman (1989) Genes Dev. 3:537-546] 참조)도 포함된다.
본 발명은 안티센스 방향으로 발현 벡터 내에서 클로닝된 본 발명의 DNA 분자를 함유하는 재조합 발현 벡터를 추가로 제공한다. 즉, 상기 DNA 분자는 MCT mRNA에 대해 안티센스인 RNA 분자의 (상기 DNA 분자의 전사에 의한) 발현이 가능하도록 조절 서열에 작동가능하게 연결된다. 안티센스 방향으로 클로닝된 핵산에 작동가능하게 연결된 조절 서열은 예를 들어, 바이러스 프로모터 및(또는) 인핸서처럼 다양한 세포 유형에서 안티센스 RNA 분자가 지속적으로 발현되도록 하는 것으로 선택할 수 있으며, 또는 안티센스 RNA가 구성적, 조직-특이적 또는 세포형 특이적으로 발현되도록 하는 조절 서열을 선택할 수도 있다. 안티센스 발현 벡터는 고효율의 조절 영역의 조절 하에서 안티센스 핵산을 생산하는 재조합 플라스미드, 파지미드 또는 약독화 바이러스의 형태일 수 있으며, 그 활성은 상기 벡터가 도입된 세포 유형에 의해 결정될 수 있다. 안티센스 유전자를 사용하여 유전자 발현을 조절 하는 것에 대해서는 문헌 [Weintraub, H. et al., Antisense RNA as a molecular tool for genetic analysis, Reviews - Trends in Genetics, Vol. 1(1) 1986]을 참조한다.
본 발명의 다른 측면은 본 발명의 재조합 발현 벡터가 도입된 숙주 세포에 관한 것이다. 용어 "숙주 세포" 및 "재조합 숙주 세포"는 본 명세서에서 혼용되고 있다. 그러한 용어는 특정 대상 세포를 지칭할 뿐만 아니라 그러한 세포의 자손 또는 잠재적인 자손도 의미하는 것으로 이해한다. 세대를 지나면서 돌연변이나 환경의 영향으로 인해 임의의 변형이 나타날 수 있기 때문에, 사실 그러한 자손은 부모 세포와 동일하지 않지만, 여전히 본 명세서에서 사용하는 용어의 범위에 포함된다.
숙주 세포는 임의의 원핵 세포 또는 진핵 세포일 수 있다. 예를 들어, MCT 단백질은 코리네박테리움 글루타미쿰과 같은 박테리아 세포, 곤충 세포, 효모 또는 포유류 세포 (예를 들어, 차이니스 햄스터 난소 세포 (CHO) 또는 COS 세포) 내에서 발현될 수 있다. 다른 적합한 숙주 세포는 당업자에게 공지되어 있다. 본 발명의 핵산 및 단백질 분자를 위한 숙주세포로서 용이하게 사용할 수 있는 코리네박테리움 글루타미쿰 관련 미생물이 표 3에 기재되어 있다.
벡터 DNA는 통상적인 형질전환 또는 형질감염 기술을 통해 원핵 또는 진핵 세포 내로 도입될 수 있다. 본원에서 사용된 용어 "형질전환" 및 "형질감염", "접합" 및 "형질도입"이란, 이종 핵산 (예를 들면, 선형 DNA 또는 RNA (예를 들면, 선형화 벡터이거나, 또는 벡터 없는 단독 유전자 구조물)) 또는 벡터 형태의 핵산 ( 예를 들면, 플라스미드, 파지, 파스피드, 파지미드, 트랜스포손 또는 다른 DNA)을 숙주 세포 내에 도입하는 다양한 공지 기술을 의미하는 것이며, 여기에는 인산 칼슘 또는 염화 칼슘 동시 침전법, DEAE-덱스트란-매개 형질감염법, 리포펙션법 (lipofection), 천연 감응법 (natural competence), 화학물질 매개 전달법, 또는 전기천공법 등이 포함된다. 숙주 세포를 형질전환 또는 형질감염시키는데 적합한 방법은 문헌 [Sambrook et al. (Molecular Cloning : A Laboratory Manual . 2 nd , ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989)] 및 다른 실험 매뉴얼에서 찾을 수 있다.
포유류 세포의 안정적 형질감염에 대해서는, 발현 벡터와 이용된 형질감염 기술에 따라, 단지 일부 소수 세포만이 그의 게놈 내로 외래 DNA를 통합한다는 것이 알려져 있다. 이들 통합체를 확인하고 선별하기 위해, 일반적으로 선택가능한 표지 (예를 들면, 항생제 내성)를 코딩하는 유전자를 목적 유전자와 함께 숙주 세포 내로 도입시킨다. 바람직한 선택가능한 표지에는 G418, 하이그로마이신 및 메토트렉세이트와 같은 약물 내성을 부여하는 것들이 포함된다. 선택가능한 표지를 코딩하는 핵산은 MCT 단백질을 코딩하는 그 벡터 상에서 숙주 세포 내로 도입될 수 있으며, 또는 별도의 벡터 상에서 도입될 수도 있다. 도입된 핵산이 안정적으로 형질감염된 세포는 약물 선택법을 통해 확인할 수 있다 (예를 들면, 선택가능한 표지 유전자가 혼입된 세포는 생존할 것이나, 그렇지 않은 다른 세포는 사멸한다).
상동성 재조합 미생물을 제조하기 위해서, 결실, 부가 또는 치환을 도입시켜 MCT 유전자를 변형 (예를 들면, 기능을 파괴)시킨 MCT 유전자의 적어도 일부를 함 유하는 벡터를 제조한다. 바람직하게는 이 MCT 유전자는 코리네박테리움 글루타미쿰 MCT 유전자이지만, 관련 박테리아로부터의 상동체뿐만 아니라 포유류, 효모 또는 곤충 기원으로부터의 상동체일 수도 있다. 바람직한 실시양태에서, 상기 벡터는 상동성 재조합에 의해 내인성 MCT 유전자가 기능적으로 파괴 (즉, 더이상 기능적 단백질을 코딩하지 않음, "녹아웃 (knock-out)" 벡터로도 지칭됨)되도록 고안된다. 별법으로, 상기 벡터는 상동성 재조합에 의해 내인성 MCT 유전자가 돌연변이되거나 달리 변형되었지만 여전히 기능적 단백질을 코딩 (즉, 상류 조절 영역이 변형되어 내인성 MCT 단백질의 발현이 변형될 수 있음)하도록 고안된다. 상동성 재조합 벡터에는 변경된 MCT 유전자 일부의 5' 및 3'의 측면에 MCT 유전자의 추가적인 핵산이 위치하여 벡터에 의해 운반된 외인성 MCT 유전자와 미생물 내의 내인성 MCT 유전자 사이에 상동성 재조합이 일어나도록 한다. 추가된 측면 MCT 핵산은 내인성 유전자와 성공적으로 상동성 재조합 되기에 충분한 길이를 갖는다. 전형적으로, 수 킬로베이스의 측면 DNA (5' 및 3' 말단 둘 다)가 상기 벡터 내에 포함된다 (예를 들어, 상동성 재조합 벡터에 대해 기술하는 문헌 [Thomas, K.R., and Capecchi, M.R. (1987) Cell 51:503] 참조). 상기 벡터는 (예를 들면, 전기천공법에 의해) 미생물 내로 도입되고, 도입된 MCT 유전자와 내인성 MCT 유전자가 상동성 재조합된 세포를 공지된 기술에 의해 선별한다.
다른 실시양태에서, 도입된 유전자의 발현을 조절할 수 있는 것으로 선택된 시스템을 함유하는 재조합 미생물을 제조할 수 있다. 예를 들어, 벡터 상에 lac 오페론의 조절을 받는 MCT 유전자가 포함된 경우에는 오직 IPTG의 존재 하에서만 MCT 유전자가 발현될 수 있다. 그러한 조절 시스템은 당업계에 공지되어 있다.
다른 실시양태에서, 숙주 세포 내의 내인성 MCT 유전자를 (예를 들면, 상동성 재조합 또는 당업계에 공지된 다른 유전적 수단에 의해) 파괴하여 그의 단백질 산물이 발현되지 않게 한다. 다른 실시양태에서, 숙주 세포 내의 도입된 MCT 유전자 또는 내인성 MCT 유전자는 하나 이상의 점 돌연변이, 결실 또는 역위에 의해 변경되지만, 여전히 기능적 MCT 단백질을 코딩한다. 다른 실시양태에서, 미생물 내에 있는 하나 이상의 조절 영역 (예를 들면, 프로모터, 억제자 또는 인듀서)이 (예를 들면, 결실, 절단, 역위 또는 점 돌연변이에 의해) 변경되어 MCT 단백질의 발현이 변한다. 당업자라면, 상기 기술한 MCT 유전자 및 단백질 변형을 하나 이상 함유한 숙주 세포가 본 발명의 방법을 이용하여 용이하게 생성될 수 있으며 이들이 본 발명에 포함되는 것임을 이해할 것이다.
배양물 중의 원핵 또는 진핵 숙주 세포와 같은 본 발명의 숙주 세포는 MCT 단백질의 생산 (즉, 발현)에 이용된다. 따라서, 본 발명은 본 발명의 숙주 세포를 이용한 MCT 단백질의 생산 방법을 추가로 제공한다. 한 실시양태에서, 상기 방법은 본 발명의 (MCT 단백질을 코딩하는 재조합 발현 벡터가 도입되거나, 야생형 또는 변형된 MCT 단백질을 코딩하는 유전자가 게놈 내로 도입된) 숙주 세포를 MCT 단백질이 생산될 때까지 적합한 배지에서 배양하는 것을 포함한다. 다른 실시양태에서, 상기 방법은 상기 배지 또는 숙주 세포로부터 MCT 단백질을 단리하는 것을 추가로 포함한다.
C.
단리된
MCT
단백질
본 발명의 다른 측면은 단리된 MCT 단백질 및 그의 생물학적 활성 부위에 관한 것이다. "단리된" 또는 "정제된" 단백질이나 그의 생물학적 활성 부위는 재조합 DNA 기술에 의해 생산된 경우 실질적으로 세포 물질이 없으며, 또는 화학적으로 합성된 경우에는 실질적으로 화학적 전구체나 다른 화학 물질이 없다. 용어 "실질적으로 세포 물질이 없는 것"이란 천연적으로 또는 재조합에 의해 MCT단백질을 생산하는 세포의 세포 구성 물질로부터 상기 단백질을 분리한 MCT 단백질 제제를 포함한다. 한 실시 태양에서, 용어 "실질적으로 세포 물질들이 없는 것"은 비-MCT 단백질 (본 명세서에서 "오염 단백질"로도 지칭함) 함량이 약 30% 미만 (건 중량), 바람직하게는 약 20% 미만, 보다 바람직하게는 약 10% 미만, 가장 바람직하게는 약 5%인 MCT 단백질 제제를 포함한다. 또한, MCT 단백질 또는 그의 생물학적 활성 부위가 재조합에 의해 생산되는 경우, 실질적으로 배양 배지가 없는 것이 바람직하다. 즉, 배양 배지 함량이 약 20 부피% 미만, 보다 바람직하게는 약 10 부피% 미만, 가장 바람직하게는 5 부피% 미만으로 나타나는 단백질 제제가 바람직하다. 용어 "실질적으로 화학적 전구체나 다른 화학 물질이 없는 것"이란 MCT 단백질의 합성에 관여한 화학적 전구체 또는 다른 화학 물질로부터 상기 단백질을 분리한 MCT 단백질 제제를 포함한다. 한 실시 태양에서, 용어 "실질적으로 화학적 전구체나 다른 화학 물질이 없는 것"은 화학적 전구체 또는 비-MCT 화학 물질의 함량이 약 30% 미만 (건 중량), 바람직하게는 약 20% 미만, 보다 바람직하게는 약 10% 미만, 가장 바람직하게는 약 5%인 MCT 단백질 제제를 포함한다. 바람직한 실시 태양에서, 단리된 단백질 또는 그의 생물학적 활성 부위는 MCT 단백질이 유래 된 생물체로부터의 오염 단백질이 없는 것이다. 전형적으로, 그러한 단백질은 예를 들어 코리네박테리움 글루타미쿰과 같은 미생물 내에서 코리네박테리움 글루타미쿰 MCT 단백질의 재조합 발현에 의해 생산된다.
본 발명의 단리된 MCT 단백질 또는 그의 일부는 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여할 수 있거나, 또는 표 1에 기재된 하나 이상의 활성을 가질 수 있다. 바람직한 실시 태양에서, 상기 단백질 또는 그의 단편은 본 발명의 아미노산 서열과 충분히 상동성인 (예, 서열 목록에서 서열 번호가 짝수인 서열) 아미노산 서열을 포함하며 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여하는 능력을 유지한다. 상기 단백질의 일부는 바람직하게는 본 명세서에서 기술한 것처럼 생물학적 활성 부위이다. 다른 바람직한 실시 태양에서, 본 발명의 MCT 단백질은 서열 목록에서 서열 번호가 짝수인 서열에 기재된 아미노산 서열을 갖는다. 또다른 바람직한 실시 태양에서, MCT 단백질은 본 발명의 뉴클레오티드 서열 (예, 서열 목록에서 서열 번호가 홀수인 서열)에 혼성화하는 (예를 들어, 엄격 조건 하에서 혼성화하는) 뉴클레오티드 서열에 의해 코딩되는 아미노산 서열을 갖는다. 또다른 바람직한 실시 태양에서, MCT 단백질은 본 발명의 핵산 서열 또는 그의 일부 중 하나와의 상동성이 약 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59% 또는 60% 이상, 바람직하게는 약 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69% 또는 70% 이상, 보다 바람직하게는 약 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79% 또는 80% 이 상, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% 또는 90% 이상, 또는 91%, 92%, 93%, 94% 이상이고, 더욱 바람직하게는 약 95%, 96%, 97%, 98%, 99% 또는 그 이상인 뉴클레오티드 서열에 의해 코딩되는 아미노산 서열을 갖는다. 또한, 상기 언급된 범위에 대해 중간 정도의 범위 및 동일성 수치 (예를 들어, 70 내지 90% 동일 또는 80 내지 95% 동일)는 본 발명에 포함되는 것이다. 예를 들어, 상기에서 상한치 및(또는) 하한치로 언급된 수치들 중 임의 조합을 이용한 동일성 수치 범위는 본 발명에 포함되는 것이다. 또한, 본 발명의 바람직한 MCT 단백질은 본 명세서에 기술된 하나 이상의 MCT 활성을 보유하는 것이 바람직하다. 예를 들어, 본 발명의 바람직한 MCT 단백질은 본 발명의 뉴클레오티드 서열에 혼성화 (예, 엄격 조건 하에서 혼성화)하는 뉴클레오티드 서열에 의해 코딩된 아미노산 서열을 포함하며, 코리네박테리움 글루타미쿰에서 세포막의 구성에 필요한 화합물의 대사 또는 이 막을 통한 분자의 운반에 관여할 수 있거나, 또는 표 1에 기재된 하나 이상의 활성을 가질 수 있다.
다른 실시 태양에서, MCT 단백질은 실질적으로 본 발명의 아미노산 서열 (예, 서열 목록에서 서열 번호가 짝수인 서열)과 상동성이며, 상기 I란에서 상술한 것처럼 자연적 변이나 돌연변이 발생으로 인하여 아미노산 서열이 다름에도 본 발명의 아미노산 서열 중 하나의 단백질의 기능적 활성을 보유한다. 따라서, 다른 실시 태양에서, MCT 단백질은 본 발명의 전체 아미노산 서열과의 상동성이 약 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59% 또는 60% 이상, 바람직하게는 약 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69% 또는 70% 이 상, 보다 바람직하게는 약 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79% 또는 80% 이상, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% 또는 90% 이상, 또는 91%, 92%, 93%, 94% 이상이고, 더욱 바람직하게는 약 95%, 96%, 97%, 98%, 99% 또는 그 이상인 아미노산 서열을 포함하며, 본 명세서에 기술된 MCT 활성 중 하나 이상을 가지고 있다. 또한, 상기 언급된 범위에 대해 중간 정도의 범위 및 동일성 수치 (예를 들어, 70 내지 90% 동일 또는 80 내지 95% 동일)는 본 발명에 포함되는 것이다. 예를 들어, 상기에서 상한치 및(또는) 하한치로 언급된 수치들 중 임의 조합을 이용한 동일성 수치 범위는 본 발명에 포함되는 것이다. 다른 실시 태양에서, 본 발명은 본 발명의 전체 아미노산 서열과 실질적으로 상동성인 전장의 코리네박테리움 글루타미쿰 단백질에 관한 것이다.
MCT 단백질의 생물학적 활성 부위는 MCT 단백질의 아미노산 서열 (예, 서열 목록에서 서열 번호가 짝수인 서열)로부터 유래된 아미노산 서열을 포함하거나 MCT 단백질과 상동성인 단백질의 아미노산 서열을 포함하며 전장 MCT 단백질 또는 MCT 단백질과 상동성이며 하나 이상의 MCT 단백질 활성을 보이는 전장 단백질보다 적은 수의 아미노산을 함유한다. 전형적으로, 생물학적 활성 부위 (펩티드, 예를 들어 5, 10, 15, 20, 30, 35, 36, 37, 38, 39, 40, 50, 100 또는 그 이상의 아미노산 길이를 갖는 펩티드)은 MCT 단백질의 하나 이상의 활성을 갖는 도메인 또는 모티프를 포함한다. 또한, 상기 단백질의 다른 영역이 결실되어 다른 생물학적 활성 부위는 재조합 기술에 의해 제조할 수 있으며 본원에서 기술한 하나 이상의 활성을 측정할 수 있다. 바람직하게는, MCT 단백질의 생물학적 활성 부위는 생물학적 활성이 있 는 하나 이상의 선택된 도메인/모티프 또는 그의 일부를 포함한다.
MCT 단백질은 바람직하게는 재조합 DNA 기술에 의해 생산된다. 예를 들어, 상기 단백질을 코딩하는 핵산 분자는 발현 벡터 (상기 기술된 바와 같음) 내로 클로닝되고, 상기 발현 벡터는 숙주 세포 (상기 기술된 바와 같음) 내로 도입되고, MCT 단백질은 상기 숙주 세포 내에서 발현된다. 그후 상기 MCT 단백질은 표준 단백질 정제 기술을 이용하여 적절한 정제 단계를 통해 세포로부터 단리될 수 있다. 재조합 발현과는 별법으로, MCT 단백질, 폴리펩티드 또는 펩티드는 표준 펩티드 합성 기술을 이용하여 화학적으로 합성할 수 있다. 게다가, 천연 MCT 단백질은, 예를 들어 본 발명의 MCT 단백질 또는 그의 일부를 사용한 표준 방법에 의해 생산될 수 있는 항-MCT 항체를 사용하여 세포 (예, 내피 세포)로부터 단리할 수 있다.
또한 본 발명은 MCT 키메라 또는 융합 단백질을 제공한다. 본 명세서에서 사용된 MCT "키메라 단백질" 또는 "융합 단백질"은 비-MCT 폴리펩티드에 작동가능하게 연결된 MCT 폴리펩티드를 포함한다. "MCT 폴리펩티드"란 MCT에 대응하는 아미노산 서열을 갖는 폴리펩티드를 지칭하며, "비-MCT 폴리펩티드"란 실질적으로 MCT 단백질과 상동성이 없는 단백질, 예를 들어 MCT 단백질과 다르며 동일한 또는 상이한 생물체로부터 유래된 단백질에 대응하는 아미노산 서열을 갖는 폴리펩티드를 의미한다. 융합 단백질에서, 용어 "작동가능하게 연결된"이란 MCT 폴리펩티드 및 비-MCT 폴리펩티드가 프레임 내에서 서로 융합된 것을 의미한다. 상기 비-MCT 폴리펩티드는 MCT 폴리펩티드의 N-말단 또는 C-말단에 융합될 수 있다. 예를 들어 한 실시 태양에서, 융합 단백질은 MCT 서열이 GST 서열의 C-말단에 융합된 GST-MCT 융합 단백질이다. 그러한 융합 단백질은 재조합 MCT 단백질의 정제를 용이하게 할 수 있다. 다른 실시 태양에서, 융합 단백질은 그의 N-말단에 이종 신호 서열을 함유하는 MCT 단백질이다. 특정한 숙주 세포 (예, 포유류 숙주 세포) 내에서, MCT 단백질의 발현 및(또는) 분비는 이종 신호 서열을 이용함으로써 증가될 수 있다.
바람직하게는, 본 발명의 MCT 키메라 또는 융합 단백질은 표준 재조합 DNA 기술에 의해 생산된다. 예를 들어, 별개의 폴리펩티드 서열을 코딩하는 DNA 단편을 통상적인 기술에 따라, 예를 들어 라이게이션을 위해 블런트-말단 또는 엇갈린 (stagger-ended) 말단을 이용는데, 적절한 말단을 만들기 위해 제한 효소로 절단하고, 경우에 따라 접착 말단을 채워 넣고, 바람직하지 않은 연결을 피하기 위해 알칼라인 포스파타제를 처리하고, 효소로 라이게이션시킴으로써 동일 프레임 내에 함께 라이게이션시킨다. 다른 실시양태에서, 융합 유전자는 자동 DNA 합성기 등을 사용하는 통상적인 기술로 합성될 수 있다. 별법으로, 2개의 연속된 유전자 단편 사이에 상보적인 오버행을 생성케하는 앵커 프라이머를 사용하여 유전자 단편을 PCR 증폭할 수 있으며, 이는 추후 어닐링되고 재증폭되어 키메라 유전자 서열을 생성한다 (예를 들어, 문헌 [Current Protocols in Molecular Biology, eds. Ausubel et al. John Wiley & Sons: 1992] 참조). 또한, 융합 부분 (예를 들면, GST 폴리펩티드)을 이미 코딩하고 있는 발현 벡터들이 많이 시판되고 있다. MCT 코딩 핵산을 그러한 발현 벡터 내로 클로닝시켜 융합 부분을 MCT 단백질로 동일 프레임 내에서 연결시킬 수 있다.
MCT 단백질의 상동체는 돌연변이유발법, 예를 들어 분별 점 돌연변이 또는 MCT 단백질의 말단의 절단에 의해 생성될 수 있다. 본원에서 사용된 바와 같이, 용어 "상동체"란, MCT 단백질의 활성에 대한 아고니스트 또는 길항제로 작용하는 MCT 단백질의 변이체 형태를 지칭하는 것이다. MCT 단백질 아고니스트의 생물학적 활성은 MCT 단백질의 것과 실질적으로 동일하거나, 그에 버금갈 수 있다. MCT 단백질의 길항제는 예를 들어 MCT 단백질을 포함하는 세포막 성분 대사의 캐스캐이드의 하류 또는 상류 구성원에 경쟁적으로 결합함으로써, 또는 이 막을 통한 화합물의 운반을 조절하는 MCT 단백질과 결합하여 전위를 방지함으로써 MCT 단백질 자연 발생 형태의 활성 하나 이상을 억제할 수 있다.
다른 실시양태에서, 상기 MCT 단백질의 상동체는 MCT 단백질 돌연변이체 (예를 들면, 말단 절단 돌연변이체)의 조합 라이브러리를 MCT 단백질 아고니스트 또는 길항제 활성에 대해 스크리닝함으로써 확인할 수 있다. 한 실시양태에서, MCT 변이체의 혼재된 (variegated) 라이브러리는 핵산 수준에서의 조합 돌연변이유발법으로 생성되며, 혼재된 유전자 라이브러리에 의해 코딩된다. MCT 변이체의 혼재된 라이브러리는 예를 들어 합성 올리고뉴클레오티드 혼합물을 유전자 서열에 효소적으로 라이게이션시켜 잠재적 MCT 서열의 다의성 (degenerate) 세트가 개별적인 폴리펩티드로서 발현가능하게 하거나, 별법으로 그 안에 MCT 서열의 세트를 함유한 거대 융합 단백질 (예를 들면, 파지 디스플레이)로서 발현가능하게 할 수 있다. 다양한 방법들을 사용하여 다의성 올리고뉴클레오티드 서열로부터 잠재적 MCT 상동체의 라이브러리를 생산할 수 있다. 자동 DNA 합성기를 사용하여 다의성 유전자 서열을 화학적으로 합성할 수 있고, 그 다음, 상기 합성 유전자를 적절한 발현 벡 터 내로 라이게이션시킬 수 있다. 유전자 다의성 세트를 이용하면 원하는 세트의 가능한 MCT 서열을 코딩하는 모든 서열을 하나의 혼합물 내에 제공할 수 있다. 다의성 올리고뉴클레오티드를 합성하는 방법은 당업계에 공지되어 있다 (예를 들면, 문헌 [Narang, S.A. (1983) Tetrahedron 39:3], 문헌 [Itakura et al. (1984) Annu. Rev. Biochem. 53:323], 문헌 [Itakura et al. (1983) Science 198:1056], 문헌 [Ike et al. (1983) Nucleic Acid Res. 11:477] 참조).
또한, MCT 단백질 코딩 유전자의 단편 라이브러리를 이용하여 MCT 단백질 상동체에 대한 스크리닝 및 그 후의 선별을 위한 MCT 단편의 혼재된 집단을 생성할 수 있다. 한 실시양태에서, 새김눈 (nick)이 분자 당 약 한 번만 일어나는 조건 하에서 뉴클레아제를 MCT 코딩 서열의 이중 가닥 PCR 단편에 처리하고, 상기 이중 가닥 DNA를 변성시키고, 상기 DNA를 탈변성 (renaturation)시켜 다른 새김눈 생성물로부터의 센스/안티센스 쌍을 포함할 수 있는 이중 가닥 DNA를 형성케하고, S1 뉴클레아제를 처리하여 재형성된 이중 가닥으로부터 단일 가닥 부분을 제거하고, 생성된 단편 라이브러리를 발현 벡터 내로 라이게이션시킴으로써 코딩 서열 단편의 라이브러리를 제조할 수 있다. 이 방법에 의해, 다양한 크기를 갖는 MCT 단백질의 N-말단, C-말단 및 내부 단편을 코딩하는 발현 라이브러리를 유도할 수 있다.
점 돌연변이 또는 말단의 절단에 의해 만들어진 조합 라이브러리의 유전자 산물 스크리닝 및 선택된 특성을 갖는 유전자 산물에 대한 cDNA 라이브러리 스크리닝을 위한 몇몇 기술이 당업계에 공지되어 있다. 그러한 기술은 MCT 상동체의 조합 돌연변이유발에 의해 생성된 유전자 라이브러리를 신속하게 스크리닝하는 데 사 용할 수 있다. 가장 널리 사용되는 기술로서, 거대 유전자 라이브러리를 스크리닝하기 위한 고처리능 분석에서 사용가능한 기술로는 대표적으로 유전자 라이브러리를 복제가능한 발현 벡터 내로 클로닝하고, 생성된 벡터 라이브러리로 적절한 세포를 형질전환시키고, 원하는 활성의 검출이 검출되는 유전자 산물을 코딩하는 벡터의 단리를 용이하게 하는 조건 하에서 조합 유전자를 발현시키는 것을 포함한다. 라이브러리 내 기능성 돌연변이의 빈도를 증가시키는 새로운 기술인 재귀적 앙상블 돌연변이유발법 (Recursive ensemble mutagenesis) (REM)을 스크리닝 분석 시험과 함께 사용하여 MCT 상동체를 확인할 수 있다 (문헌 [Arkin and Yourvan (1992) PNAS 89:7811-7815], 문헌 [Delgrave et al. (1993) Protein Engineering 6(3):327-331] 참조).
또다른 실시양태에서, 당업계에 공지된 방법을 이용한 세포계 분석법을 이용하여 변화된 MCT 라이브러리를 분석할 수 있다.
D. 본 발명의 용도 및 방법
본원에 기재한 핵산 분자, 단백질, 단백질 상동체, 융합 단백질, 프라이머, 벡터 및 숙주세포는 코리네박테리움 글루타미쿰 및 연관된 생물체의 동정, 코리네박테리움 글루타미쿰과 연관된 생물체의 게놈 맵핑, 코리네박테리움 글루타미쿰의 목적 서열의 동정 및 위치 확인, 진화 연구, 기능에 필요한 MCT 단백질 부위의 결정, MCT 단백질 활성의 조절, 1종 이상의 세포막 성분의 대사 조절, 1종 이상의 화합물의 막횡단 운반의 조절, 및 정밀 화학물질과 같은 목적 화합물의 세포 생산 조절 등의 방법 중 하나 이상에 사용할 수 있다.
본 발명의 MCT 핵산 분자는 다양한 용도를 갖는다. 첫째, 코리네박테리움 글루타미쿰 또는 그의 가까운 동족체의 존재를 확인하는데 사용할 수 있다. 또한, 혼합된 미생물군에서 코리네박테리움 글루타미쿰 또는 그의 가까운 동족체의 존재를 확인하는 데에 사용할 수 있다. 본 발명은 단일 또는 혼합된 미생물군 배양물에서 추출한 게놈 DNA를 엄격한 조건하에서 코리네박테리움 글루타미쿰에 고유한 유전자 영역에 걸친 프로브를 사용하여 탐침함으로써 상기 생물체의 존재를 확인할 수 있는 다수의 코리네박테리움 글루타미쿰 유전자의 핵산 서열을 제공한다.
코리네박테리움 글루타미쿰 자체는 병원성이 아니지만, 코리네박테리움 디프테리아 (Corynebacterium diphtheriae)와 관련이 있다. 코리네박테리움 디프테리아는 국부 및 전신성 병변을 수반하여 급속도로 진행되는 급성 발열 감염인 디프테리아의 원인균이다. 이러한 질병에서는, 호흡관 상부에 국소 병변이 발생하고 상피 세포에 괴사성 손상을 수반하고, 바실러스가 독소를 분비하여 상기 병변을 통해 신체 말단에 감염되기 쉬운 조직으로 퍼지게 된다. 심장, 근육 말초 신경, 부신, 신장, 간 및 비장을 비롯한 상기 조직에서 단백질 합성의 억제에 의해 발생하는 퇴행성 변화는 질병의 전신성 병리 현상을 일으킨다. 디프테리아는 아프리카, 아시아, 동유럽 및 구 소련 연합의 독립 국가를 비롯한 세계의 여러 지역에서 높은 발병율을 유지하고 있다. 동유럽 및 구 소련의 독립 국가에서 계속되는 유행성 디프테리아는 1990년 이래 5,000명 이상의 사망자를 가져왔다.
한 실시 태양에서, 본 발명은 개체에서 코리네박테리움 디프테리아의 존재 또는 활성을 확인하는 방법을 제공한다. 본 발명은 개체에서 본 발명의 1종 이상 의 핵산 또는 아미노산 서열 (서열 목록에 홀수 또는 짝수 서열 번호로 각각 나타냄)을 검출함으로써 개체에서 코리네박테리움 디프테리아의 존재 또는 활성을 검출하는 것을 포함한다. 코리네박테리움 글루타미쿰과 코리네박테리움 디프테리아는 관련있는 박테리아이며, 코리네박테리움 글루타미쿰의 많은 핵산 및 단백질 분자는 코리네박테리움 디프테리아의 핵산 및 단백질 분자와 상동성을 가지므로 개체에서 코리네박테리움 디프테리아를 검출하는데 사용할 수 있다.
또한, 본 발명의 핵산 및 단백질 분자는 게놈의 특정 영역의 마커로 기능을 한다. 이러한 기능은 게놈 맵핑뿐 아니라 코리네박테리움 글루타미쿰 단백질의 기능 연구에서도 유용성이 있다. 예를 들어, 코리네박테리움 글루타미쿰 게놈을 절단하여 단편을 DNA 결합 단백질과 인큐베이션시켜, 코리네박테리움 글루타미쿰의 특정 DNA 결합 단백질이 결합하는 게놈 영역을 확인할 수 있다. 단백질에 결합하는 영역은 또한 본 발명의 핵산 분자, 바람직하게는 용이하게 검출할 수 있는 표지로 탐침할 수 있다. 이와 같은 게놈 단편에 대한 핵산 분자의 결합으로 코리네박테리움 글루타미쿰의 게놈 맵에 단편의 위치를 정할 수 있으며, 상이한 효소로 여러번 수행하는 경우 단백질이 결합하는 핵산 서열을 신속하고 용이하게 결정한다. 또한, 본 발명의 핵산 분자는 연관된 종의 서열과 충분한 상동성을 가질 수 있어 브레비박테리움 락토페르멘툼 (Brevibacterium lactofermentum)과 같은 연관된 박테리아의 게놈 맵을 작성하기 위한 마커로 사용할 수 있다.
또한, 본 발명의 MCT 핵산 분자는 진화 및 단백질 구조 연구에 유용하다. 본 발명의 분자가 관여하는 대사 및 에너지 유리 과정은 매우 다양한 원핵 및 진핵 박테리아에 의해 이용된다. 다른 생물체와 유사한 효소를 코딩하는 핵산 분자 서열과 본 발명의 핵산 분자의 서열을 비교함으로써 생물체의 진화 연관성을 평가할 수 있다. 유사하게, 이러한 비교로 서열 영역의 보존 여부를 평가할 수 있으며, 이러한 보존 영역은 효소 기능에 필수적인 단백질 영역을 결정하는데 도움이 될 수 있다. 이러한 결정 방법은 단백질 공학에 유용하며, 단백질 기능의 손실없이 유발된 돌연변이에 내성을 가질 수 있는 지를 나타낼 수 있다.
본 발명의 MCT 핵산 분자의 조작으로 야생형 MCT 단백질과는 상이한 기능을 갖는 MCT 단백질을 제조할 수 있다. 이러한 단백질은 효율 또는 활성이 향상될 수 있으며, 정상 세포보다 과량으로 존재할 수 있거나 효율 또는 활성이 감소될 수 있다.
본 발명은 단백질 자체 또는 MCT 단백질의 기질 또는 결합 파트너와 상호작용시키거나 본 발명의 MCT 핵산 분자의 전사 또는 번역을 조절함으로써 MCT 단백질의 활성을 조절하는 분자를 스크리닝하는 방법을 제공한다. 상기 방법에서, 본 발명의 1종 이상의 MCT 단백질을 발현하는 생물체를 1종 이상의 시험 화합물과 접촉시켜 MCT 단백질의 활성 또는 발현수준에 대한 각각의 시험 화합물의 효과를 평가한다.
본 발명의 MCT 단백질의 변형에 의해 상기 변형된 단백질을 포함하는 코리네박테리움 글루타미쿰 균주로부터 정밀 화학물질의 수율, 생산 및(또는) 생산 효율에 직접적으로 영향을 줄 수 있는 여러 기작이 있다. 코리네박테리움 글루타미쿰의 대규모 배양으로부터 정밀 화학물질 화합물의 회수는 코리네박테리움 글루타미 쿰이 목적 화합물들을 분비하는 경우 상당히 향상되는데, 이는 이 화합물이 배양 배지로부터 (코리네박테리움 글루타미쿰 세포의 집단으로부터 추출한 것과는 반대로) 쉽게 정제될 수 있기 때문이다. 세포로부터 정밀 화학물질을 배출하는 운반체 분자의 수 또는 활성을 증가시킴으로써, 세포외 배지 중에 존재하는 생산된 정밀 화학물질의 양을 증가시키고, 따라서 더 쉽게 수획 및 정제할 수 있다. 반대로, 1종 이상의 정밀 화학물질을 효과적으로 과다생산하기 위해서는, 보조인자, 전구체 분자, 및 적절한 생합성 경로를 위한 중간체 화합물의 양을 증가시키는 것이 필요하다. 따라서, 탄소 공급원(즉, 당), 질소 공급원(즉, 아미노산, 암모늄 염), 포스페이트, 및 황 등의 영양분의 유입에 관여하는 운반체 단백질의 수 및(또는) 활성을 증가시킴으로써, 생합성 과정에서 임의 영양분 공급의 제한의 철폐로 인해, 정밀 화학물질의 생산을 증가시킬 수 있다. 또한, 지방산 및 지질은, 이러한 화합물의 생합성에 관여하는 본 발명의 1종 이상의 MCT 단백질의 활성을 최적화하거나 그의 수를 증가시킴으로써 또는 이러한 화합물의 분해에 관여하는 1종 이상의 MCT 단백질의 활성을 감소시킴으로써, 그 자체로 바람직한 정밀 화학물질이며, 코리네박테리움 글루타미쿰으로부터 지방산 및 지질 분자의 수율, 생산 및(또는) 생산 효율을 증가시킬 수 있다.
본 발명의 하나 이상의 MCT 유전자의 조작은 코리네박테리움 글루타미쿰으로부터 하나 이상의 목적하는 정밀 화학물질의 생산에 간접적으로 영향을 주는 변형된 활성을 갖는 MCT 단백질을 생성시킬 수도 있다. 예를 들어, 정상적인 생화학적 대사 과정은 이 동일한 대사 과정을 활성적으로 방해할 수 있는 다양한 폐 생성물( 예를 들어, 과산화수소 및 기타 반응성 산소 종)을 생성시킨다(예를 들어, 페록시니트리트는 티로신 측쇄를 질소화함으로써 활성 부위내에 티로신을 갖는 몇몇 효소를 실활화하는 것으로 알려져 있다(Groves,J.T. (1999) Curr. Opin. Chem. Biol. 3(2):226-235)). 이러한 폐 생성물은 통상적으로 배출되며, 대규모 발효 생산에 이용되는 코리네박테리움 글루타미쿰 균주는 하나 이상의 정밀 화학물질의 과다생산을 위해 최적화됨으로써 야생형 코리네박테리움 글루타미쿰에서 통상적으로 생산되는 것보다 더 많은 폐 생성물을 생산할 수 있다. 폐 생성물 분자의 배출에 관여하는 하나 이상의 본 발명의 MCT 분자의 활성을 최적화함으로써, 세포의 생존율을 향상시키고 효과적인 대사 활성을 유지할 수 있다. 또한, 세포내에서 높은 수준으로 존재하는 목적 정밀 화학물질은 실제로 세포에 독성을 띨 수 있어서, 이러한 화합물을 분비하는 세포의 활성을 증가시킴으로써 세포의 생존율을 향상시킬 수 있다.
또한, 적절한 양의 여러 지질 및 지방산 분자가 생산되도록 본 발명의 MCT 단백질을을 조작할 수 있다. 이는 세포막의 지질 조성에 상당한 영향을 줄 수 있다. 각 지질 타입은 다른 물리적 특성을 가질 수 있기 때문에, 막 지질 조성의 변화는 막의 유동성을 상당히 변화시킬 수 있다. 막 유동성의 변화는 막을 통한 분자의 운반에 영향을 줄 수 있으며, 이는, 상기에서 설명한 바와 같이, 폐 생성물 또는 생성된 정밀 화학물질의 유출 또는 필수 영양분의 유입을 변화시킬 수 있다. 이러한 막 유동성의 변화는 세포의 일체성에 상당한 영향을 줄 수도 있으며, 비교적 약한 막을 갖는 세포는 대규모 발효기 환경에서 세포를 손상시키거나 사멸시킬 수 있는 기계적 응력에 대해 보다 치명적이게 된다. 생성된 막이 정밀 화학물질을 생산하는데 이용되는 배양물에 존재하는 환경 조건에 대해 보다 적합하도록 막 구성을 위한 지방산 및 지질의 생산에 관여하는 MCT 단백질을 조작함으로써, 더 높은 비율이 코리네박테리움 글루타미쿰이 생존하고 증식하게 된다. 배양물 중 더 많은 수의 코리네박테리움 글루타미쿰은 배양물로부터 정밀 화학물질의 수율, 생산 또는 생산 효율을 더 크게 증가시킨다.
MCT 단백질이 코리네박테리움 글루타미쿰으로부터 정밀 화학물질의 수율을 증가시키기 위한 상기한 돌연변이 유발 방법은 한정적이지 않으며, 이러한 방법의 변형은 당업자에게 자명할 것이다. 이러한 방법의 이용, 본원에 개시된 기작의 포함, 본 발명의 핵산 및 단백질 분자를 돌연변이된 MCT 핵산 및 단백질 분자를 발현하는 코리네박테리움 글루타미쿰 또는 연관 균주의 제조에 이용하여 목적하는 화합물의 수율, 생산 및(또는) 생산 효율을 향상시킨다. 상기 목적하는 화합물은 생합성 경로의 최종 산물 및 천연 대사 경로의 중간체뿐 아니라 코리네박테리움 글루타미쿰 대사에서는 본래 일어나지 않으나 본 발명의 코리네박테리움 글루타미쿰 균주에 의해 생산되는 분자를 포함한 코리네박테리움 글루타미쿰에 의해 생산되는 모든 산물이 될 수 있다.
또한, 본 발명은 하기 실시예에 의해 예시되나, 이에 한정되는 것으로 해석해서는 안된다. 본원에 인용된 모든 참고 문헌, 특허 출원, 특허, 공개된 특허 출원의 모든 내용, 표 및 서열 목록은 참고문헌에 포함된다.
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실시예
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코리네박테리움
글루타미쿰
ATCC
13032의 전체 게놈
DNA
의
프렙
BHI 배지 (Difco 제품) 중의 코리네박테리움 글루타미쿰 (ATCC 13032) 배양물을 30℃에서 격렬히 진탕시키면서 밤새 성장시켰다. 원심분리하여 세포를 회수하여 상층액은 버리고, 세포를 5 ml 완충액-I (배양물 처음 부피의 5%에 해당함-나타낸 모든 부피는 배양 부피 100 ml에 대해 계산한 값임) 중에 재현탁했다. 완충액-I의 조성은 다음과 같았다: 140.34 g/L 수크로스, 2.46 g/L MgS04 ×7 H2O, 10 ml/L KH2PO4 용액 (100 g/L, KOH를 사용하여 pH 6.7로 조정), 50 ml/L M12 농축물 (10 g/L (NH4)2SO4, 1 g/L NaCl, 2 g/L MgSO4 ×7 H2O, 0.2 g/L CaCl2, 0.5 g/L 효모 추출물 (Difco 제품), 10 ml/L 미량 원소 혼합물 (200 mg/L FeSO4 ×H2O, 10 mg/L ZnSO4 ×7 H2O, 3 mg/L MnCl2 ×4 H2O, 30 mg/L H3BO3, 20 mg/L CoCl2 ×6 H2O, 1 mg/L NiCl2 ×6 H2O, 3 mg/L Na2MoO4 ×2 H2O, 500 mg/L 착화제 (EDTA 또는 시트르산), 100 ml/L 비타민 혼합물 (0.2 mg/L 비오틴, 0.2 mg/L 엽산, 20 mg/L p-아미노 벤조산, 20 mg/L 리보플라빈, 40 mg/L ca-판토테네이트, 140 mg/L 니코틴산, 40 mg/L 피리독솔 히드로클로라이드, 200 mg/L 미오-이노시톨). 상기 현탁액에 리소짐을 최종 농도 2.5 mg/ml로 첨가했다. 37℃에서 대략 4 시간 동안 인큐베이션시킨 다음, 세포벽을 파괴하고 원심분리하여, 원형질체를 수거했다. 펠렛을 5 ml 완충액-I으로 1 회 세척하고, 5 ml TE-완충액 (10 mM 트리스-HCl, 1 mM EDTA, pH 8)으로 1 회 세척했다. 펠렛을 4 ml TE-완충액 중에 재현탁하고, 0.5 ml SDS 용액 (10%) 및 0.5 ml NaCl 용액 (5 M)을 첨가했다. 프로테이나제 K를 최종 농도 200 ㎍/ml로 첨가한 다음, 상기 현탁액을 37℃에서 약 18 시간 동안 인큐베이션시켰다. 표준 방법을 이용하여, 페놀, 페놀-클로로포름-이소아밀알콜 및 클로로포름-이소아밀알콜로 추출하여 DNA를 정제했다. 그 다음, 1/50 부피의 3 M 아세트산 나트륨 및 2 배 부피의 에탄올을 첨가하여 DNA를 침전시킨 후, -20℃에서 30 분 동안 인큐베이션시키고, SS34 회전자 (Sorvall 제품)를 사용한 고속 원심분리기로 12,000 rpm에서 30 분 동안 원심분리했다. 상기 DNA를 20 ㎍/ml RNaseA를 함유한 1 ml TE-완충액 중에 용해시키고, 4℃에서 3 시간 이상 동안 1000 ml TE-완충액 중에 투석했다. 투석 동안, 상기 완충액을 3 회 갈아주었다. 투석된 DNA 용액을 0.4 ml씩 분취하여, 0.4 ml 2 M LiCl 및 0.8 ml 에탄올을 첨가했다. -20℃에서 30 분 동안 인큐베이션시킨 다음, 원심분리 (13,000 rpm, 독일 하나우 헤래우스 소재의 Biofuge Fresco 제품)하여 DNA를 수집했다. DNA 펠렛을 TE-완충액 중에 용해했다. 이 방법으로 프렙된 DNA를 서던 블럿팅 또는 게놈 라이브러리 제작 등의 모든 목적에 이용했다.
실시예
2:
대장균에서
코리네박테리움
글루타미쿰
ATCC13032
의 게놈 라이브러리 제작
실시예 1에 기재한 바와 같이 프렙된 DNA를 사용하여, 공지되고 수립된 방법 (예를 들면, 문헌 [Sambrook, J. et al. (1989) "Molecular Cloning: A Laboratory Manual", Cold Spring Harbor Laboratory Press] 또는 문헌 [Ausubel, F.M. et al. (1994) "Current Protocols in Molecular Biology", John Wiley & Sons] 참조)에 따라 코스미드 및 플라스미드 라이브러리를 제작했다.
임의의 플라스미드 또는 코스미드를 사용할 수 있었다. 특히, 플라스미드 pBR322 (문헌 [Sutcliffe, J.G. (1979) Proc. Natl. Acad. Sci. USA, 75:3737-3741]); pACYC177 (문헌 [Change & Cohen (1978) J. Bacteriol 134:1141-1156]), pBS 계열의 플라스미드 (pBSSK+, pBSSK- 등; 문헌 [Stratagene, LaJolla, USA]), 또는 SuperCos I (문헌 [Stratagene, LaJolla, USA]) 또는 Lorist6 (문헌 [Gibson, T.J., Rosenthal A. and Waterson, R.H. (1987) Gene 53:283-286]) 등의 코스미드를 사용했다. 구체적으로, 코리네박테리움 글루타미쿰에 사용하기 위한 유전자 라이브러리는 플라스미드 pSL 109 (문헌 [Lee, H.-S. and A.J. Sinskey (1994) J. Microbiol. Biotechnol. 4:256-263])를 사용하여 제작할 수 있다.
실시예
3:
DNA
서열분석 및 컴퓨터를 이용한 기능 분석
실시예 2에 기재한 바와 같은 게놈 라이브러리를 사용하여, 표준 방법에 따른 DNA 서열분석, 특히 ABI377 서열분석기를 사용한 쇄 종결 방법 (예를 들면, 문헌 [Fleischman, R.D. et al. (1995) "Whole-genome Random Sequencing and Assembly of Haemophilus Influenzae Rd., Science, 269:496-512)에 의한 DNA 서열분석을 수행했다. 다음의 뉴클레오티드 서열을 갖는 서열분석 프라이머를 사용했다: 5'-GGAAACAGTATGACCATG-3' (서열 677) 또는 5'-GTAAAACGACGGCCAGT-3' (서열 678).
실시예
4:
생체내
돌연변이유발법
코리네박테리움 글루타미쿰의 생체내 돌연변이유발법은 완전한 유전 정보 유지 능력이 손상된 대장균 또는 다른 미생물 (예를 들면, 바실루스 종 (Bacillus spp.) 또는 사카로마이세스 세레비지애 (Saccharomyces cerevisiae) 등의 효모)에 플라스미드 (또는 다른 벡터) DNA를 계대접종하여 수행할 수 있다. 전형적인 돌연변이유발 균주는 DNA 복구 시스템에 관한 유전자 (예를 들면, mutHLS, mutD, mutT 등; 참고를 위해서는, 문헌 [Rupp, W.D. (1996) DNA repair mechanisms, in: Escherichia coli and Salmonella, p.2277-2294, ASM: Washington]을 참조한다)에 돌연변이가 있다. 이러한 균주들은 당업자에게 공지되어 있다. 이런 균주의 사용법은 예를 들어, 문헌 [Greener, A. and Callahan, M. (1994) Strategies 7:32-34]에 설명되어 있다.
실시예
5: 대장균과
코리네박테리움
글루타미쿰
사이의
DNA
전달
여러 코리네박테리움 및 브레비박테리움 종은 자율적으로 복제되는 내인성 플라스미드 (예를 들면, pHM1519 또는 pBL1 등)를 함유하고 있다 (이에 관해 살펴보기 위해서는, 예를 들어 문헌 [Martin, J.F. et al. (1987) Biotechnology, 5:137-146]을 참조한다). 대장균 및 코리네박테리움 글루타미쿰에 사용하기 위한 셔틀 벡터는 코리네박테리움 글루타미쿰을 위한 복제 기점 및 코리네박테리움 글루타미쿰으로부터의 적당한 마커를 첨가한, 대장균에 사용하는 표준 벡터 (문헌 [Sambrook, J. et al. (1989), "Molecular Cloning: A Laboratory Manual", Cold Spring Harbor Laboratory Press] 또는 문헌 [Ausubel, F.M. et al. (1994) "Current Protocols in Molecular Biology", John Wiley & Sons])를 사용하여 쉽게 제작할 수 있다. 상기 복제 기점은 코리네박테리움 및 브레비박테리움 종에서 단리한 내인성 플라스미드로부터 얻는 것이 바람직하다. 특히, 상기 종에 관한 형질전환 마커로 사용하는 유전자는 카나마이신 내성 유전자 (예를 들면, Tn5 또는 Tn903 트란스포손 등에서 유래) 또는 클로람페니콜 내성 유전자 (문헌 [Winnacker, E.L. (1987) "From Genes to Clones-Introduction to Gene Technology, VCH, Weinheim])이다. 대장균 및 코리네박테리움 글루타미쿰 모두에서 복제되고, 유전자 과다발현 등을 포함하는 여러 목적에 사용할 수 있는 매우 다양한 셔틀 벡터의 제작법에 관한 수많은 문헌이 있다 (참고를 위해서는, 예를 들어 문헌 [Yoshihama, M. et al. (1985) J. Bacteriol. 162:591-597], 문헌 [Martin J.F. et al. (1987) Biotechnology, 5:137-146] 및 문헌 [Eikmanns, B.J. et al. (1991) Gene, 102:93-98]을 참조한다).
표준 방법을 사용하여, 관심 유전자를 상기 기재된 셔틀 벡터들 중 하나에 클로닝하고 이러한 하이브리드 벡터를 코리네박테리움 글루타미쿰 균주에 도입할 수 있다. 코리네박테리움 글루타미쿰의 형질전환은 원형질체 형질전환법 (문헌 [Kastsumata, R. et al. (1984) J. Bacteriol. 159:306-311]), 전기천공법 (문헌 [Liebl, E. et al. (1989) FEMS Microbiol. Letters, 53:399-303]) 및 특정 벡터가 사용되는 경우에는 접합법 (예를 들면, 문헌 [Schaefer, A et al. (1990) J. Bacteriol. 172:1663-1666]에 기재된 바와 같음)에 의해서도 달성될 수 있다. 또한, 코리네박테리움 글루타미쿰으로부터 플라스미드 DNA를 프렙 (당업계에 공지된 표준 방법을 사용)하고, 이것을 대장균으로 형질전환시켜 코리네박테리움 글루타미쿰에 사용하기 위한 셔틀 벡터를 대장균에 전달할 수도 있다. 이러한 형질전환 단계는 표준 방법을 사용하여 수행할 수 있지만, NM522 (문헌 [Gough & Murray (1983) J. Mol. Biol. 166:1-19]) 등과 같은 Mcr-결핍 대장균 균주를 사용하는 것이 유리하다.
pCGl (문헌 [미국 특허 제4,617,267호]) 또는 이의 단편, 및 경우에 따라 TN903으로부터의 카나마이신 내성 유전자 (문헌 [Grindley, N.D. and Joyce, C.M. (1980) Proc. Natl. Acad. Sci. USA 77 (12):7176-7180])를 포함하는 플라스미드를 사용하여 코리네박테리움 글루타미쿰 균주에서 유전자를 과다발현시킬 수 있다. 또한, 플라스미드 pSL 109 (문헌 [Lee, H.-S. and A.J.Sinskey (1994) J. Microbiol. Biotechnol. 4:256-263])를 사용하여 코리네박테리움 글루타미쿰 균주에서 유전자를 과다발현시킬 수 있다.
복제성 플라스미드를 사용하는 것 이외에도, 유전자 과다발현은 게놈으로의 통합으로 달성될 수도 있다. 코리네박테리움 글루타미쿰 또는 다른 코리네박테리움 또는 브레비박테리움 종에서의 게놈 통합은 게놈 영역(들)과의 상동성 재조합, 제한 엔도뉴클레아제 매개 통합 (REMI) (예를 들어 문헌 [독일 특허 제19823834호] 참조), 또는 트란스포손을 사용하는 등의 공지된 방법으로 수행할 수 있다. 또한, 위치 지정 방법 (예를 들면, 상동성 재조합) 또는 무작위 사건에 기초한 방법 (예를 들면, 트란스포손 돌연변이유발법 또는 REMI)을 사용한 서열의 변형, 삽입, 또는 결실에 의해 조절 영역 (예를 들면, 프로모터, 억제자, 및(또는) 인핸서)을 변형하여 관심 유전자의 활성을 조정할 수도 있다. 또한, 전사 종결자로 기능하는 핵산 서열을 본 발명의 유전자 하나 이상의 코딩 영역 3'에 삽입할 수도 있다; 이러한 종결자는 당업계에 공지되어 있으며, 예를 들면 문헌 [Winnacker, E.L. (1987) From Genes to Clones-Introduction to Gene Technology. VCH: Weinheim]에 기재되어 있다.
실시예
6: 돌연변이 단백질의 발현 평가
돌연변이된 단백질이 형질전환된 숙주 세포에서 그 단백질의 활성을 관찰한 결과, 상기 돌연변이 단백질이 야생형 단백질과 유사한 방식 및 유사한 양으로 발현된다는 사실을 알아냈다. 돌연변이 유전자의 전사 수준 (유전자 산물로의 번역에 이용가능한 mRNA 양에 관한 지표)을 확인하는 유용한 방법은 노던 블럿팅 (참고를 위해서는, 예를 들어 문헌 [Ausubel et al. (1988) Current Protocols in Molecular Biology, Wiley: New York]을 참조한다)을 수행하는 것인데, 이는 생물 배양물의 전체 RNA를 추출하여 겔상에서 전개시키고, 이를 안정한 매트릭스로 전달한 후, 관심 유전자에 결합하도록 고안하여 검출가능한 태그 (통상적으로 방사성 또는 화학발광성 태그)로 표지한 프라이머와 인큐베이션시켜, 상기 프로브의 결합 및 그 결합량이 상기 관심 유전자의 mRNA 존재 여부 및 양을 또한 지시하는 방법이다. 이러한 정보는 돌연변이 유전자의 전사 정도에 관한 증거가 된다. 코리네박테리움 글루타미쿰의 세포내 전체 RNA는 예를 들면, 문헌 [Bormann, E.R. et al. (1992) Mol. Microbiol. 6:317-326]에 기재된 것과 같이 당업계에 공지된 여러 방법들을 이용하여 프렙할 수 있다.
이 mRNA로부터 번역된 단백질의 존재 여부 또는 그 상대량을 평가하기 위해서는, 웨스턴 블럿팅과 같은 표준 기술을 사용할 수 있다 (예를 들어, 문헌 [Ausubel et al. (1988) Current Protocols in Molecular Biology, Wiley: New York]을 참조한다). 이 방법에서, 세포내 전체 단백질을 추출하고, 겔 전기영동법으로 분리한 후, 이를 니트로셀룰로스 등과 같은 매트릭스로 전달하여, 원하는 단백질에 특이적으로 결합하는 항체 등의 프로브와 인큐베이션시킨다. 통상적으로, 이 프로브는 쉽게 검출될 수 있는 화학발광성 또는 비색성 표지로 태그된 것이다. 관찰된 표지의 존재 여부 및 양은 그 세포 내에서 원하는 돌연변이 단백질의 존재 여부 및 양을 지시한다.
실시예 7: 유전적으로 변형된 코리네박테리움 글루타미쿰의 성장-배지 및 배양 조건
유전적으로 변형된 코리네박테리아를 합성 또는 천연 성장 배지에서 배양한다. 코리네박테리아의 수많은 상이한 성장 배지는 당업계에 공지되어 있으며, 또한 쉽게 이용가능하다 (문헌 [Lieb et al. (1989) Appl. Microbiol. Biotechnol., 32:205-210], 문헌 [von der Osten et al. (1998) Biotechnology Letters, 11:11-16], 문헌 [독일 특허 제4,120,867호], 문헌 [Liebl (1992) "The Genus Corynebacterium", in: The Procaryotes, Volume II, Balows, A. et al., eds. Springer-Verlag]). 상기 배지는 1 종 이상의 탄소 공급원, 질소 공급원, 무기염, 비타민 및 미량 원소로 구성된다. 바람직한 탄소 공급원은 단당류, 이당류, 또는 다당류 등의 당이다. 예를 들면, 글루코스, 프룩토스, 만노스, 갈락토스, 리보스, 소르보스, 리불로스, 락토스, 말토스, 수크로스, 라피노스, 녹말 또는 셀룰로스가 매우 훌륭한 탄소 공급원으로 기능한다. 또한, 당 정제시 생성되는 당밀 또는 기타 부산물 등과 같은 복합 화합물 등을 통해 당을 배지에 공급할 수도 있다. 또한, 상이한 탄소 공급원들의 혼합물을 공급하는 것도 유리할 수 있다. 다른 가능한 탄소 공급원은 메탄올, 에탄올, 아세트산 또는 락트산 등의 알콜 및 유기산이다. 질소 공급원은 통상적으로 유기 또는 무기 질소 화합물, 또는 이러한 화합물을 함유하는 물질이다. 질소 공급원의 예로는 암모니아 기체 또는 NH4Cl 또는 (NH4)2SO4, NH40H 등의 암모니아염, 질산염, 우레아, 아미노산 또는 옥수수 침유 (steep liquor), 대두 가루, 대두 단백질, 효모 추출물, 육류 추출물 등의 복합 질소 공급원 등이 있다.
배지에 포함될 수 있는 무기 염 화합물로는 칼슘, 마그네슘, 나트륨, 코발트, 몰리브데늄, 칼륨, 망간, 아연, 구리 및 철의 염산염, 인산염, 또는 황산염 등이 있다. 킬레이트 화합물을 배지에 첨가하여 금속 이온을 용액 상태로 유지할 수 있다. 특히 유용한 킬레이트 화합물로는 카테콜 또는 프로토카테쿠에이트 등의 디히드록시페놀, 또는 시트르산 등의 유기산 등이 있다. 또한, 통상적으로 배지에는 비타민 또는 성장 촉진제 등의 다른 성장 요소가 포함되어 있고, 이들의 예로는 비오틴, 리보플라빈, 티아민, 엽산, 니코틴산, 판토페네이트 및 피리독신 등이 있다. 성장 요소 및 염은 흔히 효모 추출물, 당밀, 옥수수 침유 등과 같은 복합 배지 성분에서 생긴다. 배지 화합물의 정확한 조성은 이후의 실험에 따라 크게 달라지고, 각각의 특정 경우마다 따로 결정된다. 배지의 최적화에 관한 정보는 문헌 ["Applied Microbiol. Physiology, A Practical Approach (eds. P.M. Rhodes, P.F. Stanbury, IRL Press (1997) pp.53-73, ISBN 0 19 963577 3)]에서 찾을 수 있다. 또한, 스탠다드 1 (Merck 제품) 또는 BHI (곡물 속 침출물, DIFCO 제품) 등과 같이 제조 회사로부터의 성장배지 중에서 선택할 수도 있다.
모든 배지 성분들을 열처리 (1.5 bar 및 121℃에서 20 분) 또는 멸균 여과로 멸균시킨다. 이 성분들을 한꺼번에 멸균하거나, 필요에 따라 따로따로 멸균할 수 있다. 모든 배지 성분들은 배양 초기부터 존재하거나, 경우에 따라 연속적으로 또는 배치식으로 (batchwise) 첨가될 수 있다.
배양 조건은 각 실험마다 따로 정의된다. 온도는 15℃와 45℃ 사이의 범위여야 한다. 온도는 일정하게 유지하거나 실험하는 동안 변경할 수 있다. 배지의 pH는 5 내지 8.5의 범위, 바람직하게는 약 7.0이어야 하며, 배지에 완충액을 첨가하여 유지시킬 수 있다. 이러한 목적으로 사용할 수 있는 완충액의 예로는 인산 칼륨 완충액 등이 있다. MOPS, HEPES, ACES 등과 같은 합성 완충액을 대안적으로 사용하거나 동시에 사용할 수 있다. 또한, 배양하는 동안 NaOH 또는 NH4OH를 첨가하여 배양물의 pH를 일정하게 유지시킬 수도 있다. 효모 추출물 등의 복합 배지 성분이 사용되는 경우, 많은 복합 화합물들은 완충 성능이 높기 때문에, 추가의 완충액에 대한 요구를 감소시킬 수 있다. 미생물 배양에 발효기를 사용하는 경우, pH는 암모니아 기체를 사용하여 제어할 수도 있다.
인큐베이션 시간 범위는 통상적으로 수 시간 내지 수 일이다. 이 시간은 브로스 (broth)에 축적되는 생성물의 양이 최대가 되도록 선택한다. 개시한 배양 실험을 상이한 크기의 마이크로타이터 플레이트, 유리관, 유리 플라스크 또는 유리 또는 금속 발효기 등의 다양한 용기에서 수행할 수 있다. 수많은 클론을 스크리닝하기 위해서는, 미생물을 배플 (baffle)이 있거나 없는 마이크로타이터 플레이트, 유리관 또는 진탕 플라스크에서 배양해야 한다. 요구되는 성장 배지를 100 ml 진탕 플라스크에 10% (부피비) 채워 사용하는 것이 바람직하다. 이 플라스크들은 속도 범위 100-300 rpm의 회전 진탕기 상에서 진탕 (진폭 25 mm)되어야 한다. 증발에 의한 손실량은 대기를 습하게 유지함으로써 감소될 수 있다; 별법으로, 증발에 의한 손실량을 정확하게 보정해야 한다.
유전적으로 변형된 클론을 시험하는 경우, 비변형된 대조 클론 또는 임의의 인서트가 없는 기본 플라스미드를 함유하는 대조 클론도 시험해야 한다. 30℃에서 인큐베이션한 CM 플레이트 (10 g/L 글루코스, 2.5 g/L NaCl, 2 g/L 우레아, 10 g/L 폴리펩톤, 5 g/L 효모 추출물, 5 g/L 육류 추출물, 22 g/L 아가, 2 M NaOH을 사용하여 pH 6.8로 조정) 등과 같은 아가 플레이트 상의 세포를 OD600 0.5-1.5이 되도록 배지에 접종한다. 배지 접종은 CM 플레이트로부터의 코리네박테리움 글루타미쿰 세포의 염수 현탁액을 도입하거나, 이 박테리아의 예비배양물을 첨가하여 수행한다.
실시예
8: 돌연변이 단백질의 기능에 관한
시험관내
분석
효소의 활성 및 반응 속도 파라미터의 측정 방법은 당업계에 잘 수립되어 있다. 임의의 주어진 변경된 효소의 활성 측정 실험은 야생형 효소의 비활성(比活性)에 맞추어야 하며, 당업자라면 이를 잘 수행할 수 있다. 효소의 구조, 반응 속도, 원리, 방법, 적용에 관한 구체적인 세부사항 뿐 아니라 효소에 관한 통상적인 개요 및 많은 효소들의 활성 측정 방법의 예를 하기의 참고문헌 등에서 찾을 수 있다: 문헌 [Dixon, M., and Webb, E.C., (1979) Enzymes. Longmans: London; Fersht, (1985) Enzyme Structure and Mechanism. Freeman: New York], 문헌 [Walsh, (1979) Enzymatic Reaction Mechanisms. Freeman: SanFrancisco], 문헌 [Price, N.C., Stevens, L. (1982) Fundamentals of Enzymology. Oxford Univ. Press: Oxford], 문헌 [Boyer, P.D., ed. (1983) The Enzymes, 3rd ed. Academic Press: New York], 문헌 [Bisswanger, H., (1994) Enzymkinetik, 2nd ed. VCH: Weinheim (ISBN 3527300325)], 문헌 [Bergmeyer, H.U., Bergmeyer, J., Grassl, M., eds. (1983-1986) Methods of Enzymatic Analysis, 3rd ed., vol.I-XII, Verlag Chemie: Weinheim], 및 문헌 [Ullmann's Encyclopedia of Industrial Chemistry (1987) vol.A9, "Enzymes". VCH: Weinheim, p.352-363].
DNA에 결합하는 단백질 활성은 DNA 밴드-변위 분석법 (겔 지연 분석법 (gel retardation assays)으로 지칭되기도 함) 등과 같이 잘 수립된 여러 방법들을 사용하여 측정할 수 있다. 상기 단백질들이 다른 분자들의 발현에 미치는 영향은 리포터 유전자 분석법 (예를 들면, 문헌 [Kolmar, H. et al. (1995) EMBO J. 14:3895-3904] 및 이 문헌에서 인용한 참고 문헌에 기재된 바와 같음)을 사용하여 측정할 수 있다. β-갈락토시다제 등의 효소, 녹색 형광 단백질 및 기타 여러가지를 사용하는 리포터 유전자 시험 시스템은 원핵 세포 및 진핵 세포 모두에의 적용에 대해 공지되어 있으며, 잘 수립되어 있다.
막 수송 단백질의 활성 측정은 문헌 [Gennis, R.B. (1989) "Pores, Channels and Transporters", in Biomembranes, Molecular Structure and Function, Springer: Heidelberg, p.85-137, 199-234, 및 270-322]에 기재된 기술 등에 따라 수행될 수 있다.
실시예
9: 원하는 생성물 생산에 대한 돌연변이 단백질의 영향 분석
코리네박테리움 글루타미쿰에서의 유전적 변형이 원하는 화합물 (예를 들면, 아미노산)의 생산에 미치는 영향은 변형된 미생물을 적당한 조건 (예를 들면, 상기 기재한 바와 같음) 하에 배양하고, 원하는 생성물 (즉, 아미노산)의 생성 증가에 관여한 배지 성분 및(또는) 세포내 성분을 분석하여 평가할 수 있다. 이러한 분석 기술은 당업자에게 공지되어 있으며, 분광분석법, 박층크로마토그래피법, 각종 염색법, 효소적 및 미생물학적 방법, 및 고성능 액체 크로마토그래피법 등과 같은 분석용 크로마토그래피법 등이 있다 (예를 들면, 문헌 [Ullman, Encyclopedia of Industrial Chemistry, vol.A2, p.89-90 및 p.443-613, VCH: Weinheim (1985)], 문헌 [Fallon, A. et al., (1987) "Applications of HPLC in Biochemistry" in: Laboratory Techniques in Biochemistry and Molecular Biology, vol.17], 문헌 [Rehm et al. (1993) Biotechnology, vol.3, Chapter III: "Product recovery and purification", page 469-714, VCH: Weinheim], 문헌 [Belter, P.A. et al. (1988) Bioseparations: downstream processing for biotechnology, John Wiley and Sons], 문헌 [Kennedy, J.F. and Cabral, J.M.S. (1992) Recovery processes for biological materials, John Wiley and Sons], 문헌 [Shaeiwitz, J.A. and Henry, J.D. (1988) Biochemical separations, in: Ulmann's Encyclopedia of Industrial Chemistry, vol.B3, Chapter 11, page 1-27, VCH: Weinheim], 및 문헌 [Dechow, F.J. (1989) Separation and purification techniques in biotechnology, Noyes Publications] 참조).
최종 발효 생성물의 측정 뿐 아니라, 중간체 및 부산물 등과 같이 원하는 화합물의 생성에 이용된 대사 경로 중의 다른 성분들의 분석, 전체적인 화합물 생성 효율의 측정 또한 가능하다. 분석 방법으로는 배지 내의 영양분 (예를 들면, 당, 탄화수소, 질소 공급원, 인산염 및 기타 이온) 함량 측정, 생물집단 (biomass)의 조성 및 증식량 측정, 생합성 경로의 공통 대사물질의 생성 분석, 및 발효 동안에 생성된 기체 측정 등이 있다. 이러한 측정을 위한 표준 방법은 문헌 [Applied Microbial Physiology, A Practical Approach, P.M.Rhodes and P.F.Stanbury, eds., IRL Press, p.103-129, 131-163, 및 165-192 (ISBN:0199635773) 및 이 문헌에서 인용한 참고 문헌]에 약술되어 있다.
실시예
10:
코리네박테리움
글루타미쿰
배양물로부터의 원하는 생성물 정제
당업계에 공지된 각종 방법을 사용하여, 코리네박테리움 글루타미쿰 세포 또는 상기 기재한 배양물의 상층액으로부터 원하는 생성물을 회수할 수 있다. 원하는 생성물이 세포로부터 분비되지 않는 경우, 배양물을 저속 원심분리하여 세포를 수거하고, 기계적인 힘 또는 초음파 등의 표준 기술로 세포를 용균시킬 수 있다. 원심분리로 세포 부스러기를 제거하고, 가용성 단백질을 함유하는 상층액 부분은 남겨 원하는 화합물의 추가의 정제에 사용한다. 코리네박테리움 글루타미쿰 세포로부터 생성물이 분비되는 경우, 배양물을 저속 원심분리하여 세포를 제거하고, 상층액 부분은 남겨 추가의 정제에 사용한다.
상기 두 가지 정제 방법 중 임의의 방법에 의한 상층액 부분을 적당한 수지를 사용한 크로마토그래피에 적용하여, 원하는 분자는 크로마토그래피 수지 상에 남지만 샘플 중의 많은 불순물은 남지 않게 하거나, 불순물들은 수지에 남지만 원하는 분자는 남지 않게 한다. 필요에 따라, 동일하거나 상이한 크로마토그래피 수지를 사용하여 이러한 크로마토그래피 단계를 반복할 수 있다. 당업자라면, 적합한 크로마토그래피 수지를 선택하고 특정 분자의 정제에 대해 가장 효과적으로 이를 적용하는 것에 숙달되어 있을 것이다. 정제된 생성물을 여과법 또는 한외여과법으로 농축시켜, 생성물의 안정성이 최대가 되는 온도에 보관할 수 있다.
당업계에 공지된 정제 방법은 다양하며, 상기 기재한 정제법에 제한되지 않는다. 이러한 정제 기술은 예를 들어 문헌 [Bailey, J.E. & Ollis, D.F. Biochemical Engineering Fundamentals, McGraw-Hill: New York (1986)]에 기재되어 있다.
단리된 화합물의 확인 및 순도는 당업계의 표준 기술로 평가될 수 있다. 여기에는 고성능 액체 크로마토그래피 (HPLC)법, 분광분석법, 염색법, 박층 크로마토그래피법, NIRS, 효소적 분석법, 또는 미생물학적 방법 등이 있다. 상기 분석 방법은 하기 문헌에서 검토된다: 문헌 [Patek et al. (1994) Appl. Environ. Microbiol. 60:133-140], 문헌 [Malakhova et al. (1996) Biotekhnologiya 11:27-32], 문헌 [Schmidt et al. (1998) Bioprocess Engineer. 19:67-70], 문헌 [Ulmann's Encyclopedia of Industrial Chemistry, (1996) vol.A27, VCH: Weinheim, p.89-90, p.521-540, p.540547, p.559-566, p.575-581 및 p.581-587], 문헌 [Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley and Sons], 및 문헌 [Fallon, A. et al. (1987) Applications of HPLC in Biochemistry in: Laboratory Techniques in Biochemistry and Molecular Biology, vol.17].
실시예
11: 본 발명의 유전자 서열 분석
서열 비교 및 2 가지 서열 사이의 상동성 (%) 측정은 당업계에 공지된 기술이며, 이는 문헌 [Karlin and Altschul (1990) Proc. Natl. Acad. Sci. USA 87:2264-68]의 알고리즘을 문헌 [Karlin and Altschul (1993) Proc. Natl. Acad. Sci. USA 90:5873-77]에서와 같이 변형시킨 알고리즘 등의 수리적 알고리즘을 사용하여 수행할 수 있다. 상기 알고리즘을 문헌 [Altschul, et al. (1990) J. Mol. Biol. 215:403-10]의 NBLAST 및 XBLAST 프로그램 (버젼 2.0)에 도입한다. 스코어 = 100, 워드렝쓰 (wordlength) = 12의 NBLAST 프로그램으로 BLAST 뉴클레오티드를 검색하여 본 발명의 MCT 핵산 분자에 상동성인 뉴클레오티드 서열을 얻을 수 있다. 스코어 = 50, 워드렝쓰 = 3의 XBLAST 프로그램으로 BLAST 단백질을 검색하여 본 발명의 MCT 단백질 분자에 상동성인 아미노산 서열을 얻을 수 있다. 문헌 [Altschul et al., (1997) Nucleic Acids Res. 25 (17):3389-3402]에 기재된 바와 같이 갭 BLAST를 이용하여 비교용 갭 정렬을 얻을 수 있다. 당업자라면, BLAST 및 갭 BLAST 프로그램을 이용할 때, 분석할 구체적인 서열에 대해 프로그램 (예를 들면, XBLAST 및 NBLAST)의 파라미터를 최적화하는 방법을 알 것이다.
서열 비교에 이용되는 수리적 알고리즘의 다른 예로는 문헌 [Meyers and Miller (1988) Comput. Appl. Biosci. 4:11-17]의 알고리즘이 있다. 이 알고리즘을 GCG 서열 정렬 소프트웨어 패키지의 일부인 ALIGN 프로그램 (버젼 2.0)에 도입한다. 아미노산 서열 비교를 위해 ALIGN 프로그램을 이용하는 경우, PAM 120 중량 잔기 표, 갭 길이 패널티 12, 및 갭 패널티 4를 사용할 수 있다. 추가의 서열 분석용 알고리즘이 당업계에 공지되어 있으며, 문헌 [Torelli and Robotti (1994) Comput. Appl. Biosci. 10:3-5]에 기재된 ADVANCE 및 ADAM., 및 문헌 [Pearson and Lipman (1988) P.N.A.S. 85:2444-8]에 기재된 FASTA를 포함한다.
또한, 2 개의 아미노산 서열 사이의 상동성 (%) 비교는 Blosum 62 매트릭스 또는 PAM250 매트릭스, 및 갭 중량 12, 10, 8, 6, 또는 4 및 길이 중량 2, 3, 또는 4를 사용하는 GCG 소프트웨어 패키지 (http://www.gcg.com에서 이용가능함) 중의 GAP 프로그램을 사용하여 수행할 수도 있다. 2 개의 핵산 서열 사이의 상동성 (%) 비교는 갭 중량 50 및 길이 중량 3 등의 표준 파라미터로 GCG 소프트웨어 패키지 중의 GAP 프로그램을 사용하여 수행할 수 있다.
당업계에 공지된 기술을 사용하여 본 발명의 유전자 서열과 젠뱅크 (Genbank)의 유전자 서열을 비교 분석했다 (예를 들면, 문헌 [Bexevanis and Ouellette, eds. (1998) Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins. John Wiley and Sons: New York] 참조). 본 발명의 유전자 서열과 젠뱅크의 유전자 서열을 3-단계 방법으로 비교했다. 제1단계에서, 본 발명의 서열 각각을 젠뱅크의 뉴클레오티드 서열에 대해 BLASTN 분석 (예를 들면, 국소 정렬 분석)하고, 추가의 분석을 위해 상위 500 개의 히트 (hit)를 남겨 두었다. 그 다음에, 상기 500 히트에 대해 FASTA 검색 (예를 들면, 서열 중 한정된 영역을 정렬하는, 조합된 국소 및 전반적 정렬 분석)을 수행했다. 이어서, GCG 소프트웨어 패키지 중의 GAP 프로그램을 사용하여 (표준 파라미터 사용), 본 발명의 각 유전자 서열을 상위 3 개의 FASTA 히트 각각에 전반적으로 정렬했다. 정확한 결과를 얻기 위해서, 젠뱅크에서 선별한 서열들의 길이를 당업계에 공지된 방법을 사용하여 해당 서열의 길이에 맞춰 조정했다. 상기 분석 결과를 표 4에 기재했다. 이렇게 얻은 데이타는 GAP (전반적) 분석 단독만을 수행하여 본 발명의 각 유전자를 젠뱅크의 참고 서열 각각과 비교하여 얻은 데이터와 동일하였으나, 상기 데이타베이스 - 광범위한 GAP (전반적) 분석과 비교할 때, 필요한 컴퓨터 이용 시간은 훨씬 감소했다. 본 발명의 서열 중 정렬이 되지 않은 것은 표 4에서 정렬 정보가 없는 컷오프 (cutoff) 값으로 나타냈다. 또한, 당업자라면, 표 4에서 GAP 정렬 상동성 (%)을 "상동성 (%) (GAP)"란 표제 하에 유럽식 숫자 포맷으로 열거하였으며, 여기서, ','는 소수점을 의미한다는 것을 이해할 것이다. 예를 들어, 이 단(段)에서 "40,345"란 값은 "40.345%"를 뜻한다.
실시예
12:
DNA
미세배열체의
제작 및 시행
본 발명의 서열은 DNA 미세배열체 (microarray) (DNA 배열체 (array)의 고안, 방법, 및 용도는 당업계에 공지되어 있으며, 문헌 [Schena, M. et al. (1995) Science 270:467-470], 문헌 [Wodicka, L. et al. (1997) Nature Biotechnology 15:1359-1367], 문헌 [DeSaizieu, A. et al. (1998) Nature Biotechnology 16:45-48], 및 문헌 [DeRisi, J.L. et al. (1997) Science 278:680-686)] 등에 기재되어 있음)의 제작 및 적용에 추가로 이용될 수 있다.
DNA 미세배열체는 니트로셀룰로스, 나일론, 유리, 실리콘, 또는 기타 물질로 구성된 고체 또는 유연한 지지체이다. 핵산 분자들은 이 표면에 순차적인 방식으로 부착될 수 있다. 적절하게 표지한 후, 다른 핵산 또는 핵산 혼합물을 상기 고정된 핵산 분자에 혼성화시킬 수 있고, 상기 표지를 이용하여 한정된 영역에서 혼성화된 분자들의 개별적 신호 강도를 모니터링하고 측정할 수 있다. 이 방법을 이용하면, 적용한 핵산 샘플 또는 혼합물 중의 모든 핵산 또는 선택된 핵산의 상대량 또는 절대량을 동시에 정량할 수 있다. 그러므로, DNA 미세배열체는 대량의 (6800 개 이상) 핵산 발현의 동시 분석을 가능케한다 (예를 들면, 문헌 [Schena, M. (1996) BioEssays 18 (5):427-431] 참조).
본 발명의 서열은 중합효소 연쇄 반응 등의 핵산 증폭 반응으로 1 종 이상의 코리네박테리움 글루타미쿰 유전자의 한정된 영역을 증폭시킬 수 있는 올리고뉴클레오티드 프라이머의 고안에 이용될 수 있다. 5' 또는 3' 올리고뉴클레오티드 프라이머 또는 적절한 링커 (linker)의 선택 및 고안으로 PCR 산물을 상기 기재한 (또한, 예를 들어 문헌 [Schena, M. et al. (1995) Science 270:467-470]에도 기재되어 있음) 지지체 매질의 표면에 공유결합으로 부착할 수 있다.
또한, 핵산 미세배열체는 문헌 [Wodicka, L. et al. (1997) Nature Biotechnology 15:1359-1367]에 기재된 바와 같이, 계내 올리고뉴클레오티드 합성법으로 제작될 수도 있다. 사진석판법 (photolithographic method)에 따라, 정확히 한정된 영역의 매트릭스를 빛에 노출시킨다. 이로써, 빛에 불안정한 보호기가 활성화되어 뉴클레오티드 첨가가 일어나지만, 빛이 차폐된 영역에는 어떠한 변형도 일어나지 않는다. 그 후의 보호 및 광 활성화 사이클에 의해 한정된 위치에서 상이한 올리고뉴클레오티드가 합성된다. 본 발명의 유전자의 작은 한정 영역을 미세배열체 상에서의 고상 올리고뉴클레오티드 합성법으로 합성할 수 있다.
샘플 또는 뉴클레오티드 혼합물에 존재하는 본 발명의 핵산 분자는 미세배열체와 혼성화할 수 있다. 이러한 핵산 분자들은 표준 방법에 따라 표지될 수 있다. 간략하게, 동위원소 또는 형광 표지한 뉴클레오티드를 예를 들어, 역전사 동안 또는 DNA 합성 동안 혼입하여 핵산 분자 (예를 들면, mRNA 분자 또는 DNA 분자)를 표지한다. 표지된 핵산을 미세배열체에 혼성화하는 방법은 문헌 (예를 들어, 문헌 [Schena, M. et al. (1995) 상기 문헌], 문헌 [Wodicka, L. et al. (1997), 상기 문헌] 및 문헌 [DeSaizieu A. et al. (1998), 상기 문헌])에 기재되어 있다. 혼성화된 분자의 검출 및 정량화 방법은 혼입된 특정 표지에 따라 달라진다. 방사성 표지는 예를 들어, 문헌 [Schena, M. et al. (1995) 상기 문헌]에 기재된 방법으로 검출할 수 있고, 형광 표지는 예를 들어, 문헌 [Shalon et al. (1996) Genome Research 6:639-645]의 방법으로 검출할 수 있다.
상기 기재한 바와 같이, 본 발명의 서열을 DNA 미세배열체 기술에 적용하면 상이한 균주의 코리네박테리움 글루타미쿰 또는 다른 코리네박테리아를 비교 분석할 수 있다. 예를 들어, 개개의 전사체 프로필에 기초한 균주들 사이의 변이체 연구 및 병원성, 생산성 및 스트레스 내성 등과 같은 특정 및(또는) 원하는 균주 특성에 중요한 유전자의 확인은 핵산 배열법으로 용이해진다. 또한, 핵산 배열 기술을 사용하여, 발효 반응 과정 동안 본 발명의 유전자 발현 프로필을 비교할 수 있다.
실시예
13:
세포내
단백질 집단의
동력학
(動力學) 분석 (프로테오믹스)
본 발명의 유전자, 조성물, 및 방법을 '프로테오믹스 (proteomics)'라 지칭되는, 단백질 집단의 상호작용 및 동력학 연구에 적용할 수 있다. 관심 단백질 집단에는 코리네박테리움 글루타미쿰의 전체 단백질 집단 (예를 들면, 다른 생물의 단백질 집단과의 비교시), 특정 환경 조건 또는 대사 조건 (예를 들면, 발효동안, 고온 또는 저온에서, 또는 높은 pH 또는 낮은 pH) 하에서 활성인 단백질 집단, 또는 성장 및 발생의 특정 시기 동안 활성인 단백질 집단 등이 있으나 이에 제한되는 것은 아니다.
겔 전기영동법 등의 각종 공지된 기술로 단백질 집단을 분석할 수 있다. 세포내 단백질은 용균 또는 추출 등으로 얻을 수 있고, 다양한 전기영동 기술을 사용하여 서로 분리해낼 수 있다. 소듐 도데실 술페이트 (sodium dodecyl sulfate) 폴리아크릴아미드 겔 전기영동 (SDS-PAGE)은 단백질들을 주로 이들의 분자량에 따라 분리한다. 등전점 포커싱 (isoelectric focusing) 폴리아크릴아미드 겔 전기영동법 (IEF-PAGE)은 단백질들을 그들의 등전점에 따라 분리한다 (아미노산 서열 뿐 아니라 그 단백질의 번역후 변형체도 분리해냄을 의미함). 또한, 더욱 바람직한 단백질 분석법은 2D-겔 전기영동법으로 공지된, IEF-PAGE 및 SDS-PAGE 둘다의 연속 병행법이다 (예를 들면, 문헌 [Hermann et al. (1998) Electrophoresis 19:3217-3221], 문헌 [Fountoulakis et al. (1998) Electrophoresis 19:1193-1202], 문헌 [Langen et al. (1997) Electrophoresis 18:1184-1192], 문헌 [Antelmann et al. (1997) Electrophoresis 18:1451-1463]에 기재되어 있음). 또한, 모세관 겔 전기영동법 등과 같이 당업계에 공지된 다른 분리 기술을 이용하여 단백질을 분리할 수도 있다.
이러한 방법으로 분리된 단백질을 염색 또는 표지 등의 표준 기술로 가시화할 수 있다. 적당한 염색약은 당업계에 공지되어 있으며, 쿠마시 브릴리안트 블루, 실버 염색약, 또는 시프로 루비 (Sypro Ruby) (Molecular Probes 제품) 등과 같은 형광 염료 등이 있다. 방사성 표지된 아미노산 또는 기타의 단백질 전구체 (예를 들면, 35S-메티오닌, 35S-시스테인, 14C-표지된 아미노산, 15N-아미노산, 15NO3 또는 15NH4 + 또는 13C-표지된 아미노산)를 코리네박테리움 글루타미쿰 배지에 포함시키면, 세포로부터의 단백질을 분리해내기 전에 이들을 표지할 수 있다. 유사하게, 형광 표지를 이용할 수 있다. 이렇게 표지된 단백질을 상기 기재한 기술에 따라 추출, 단리 및 분리할 수 있다.
상기 기술로 가시화된 단백질은 사용된 염료 또는 표지의 양을 측정하여 더욱 분석될 수 있다. 주어진 단백질의 양은 광학적 방법 등을 이용하여 정량적으로 측정할 수 있고, 동일 겔 또는 다른 겔 중의 다른 단백질 양과 비교할 수 있다. 광학적 비교법, 분광법, 이미지 스캐닝 및 겔 분석, 또는 사진용 필름 및 스크린의 사용 등을 통해 겔 상의 단백질을 비교할 수 있다. 상기 기술들은 당업계에 공지되어 있다.
임의의 주어진 단백질이 무엇인지 결정하기 위해, 직접적인 서열분석법 또는 다른 표준 기술을 이용할 수 있다. 예를 들면, N- 및(또는) C-말단 아미노산 서열분석법 (예를 들면, 에드만 분해법) 및 질량 분광분석법 (특히, MALDI 또는 ESI 기술 (예를 들면, 문헌 [Langen et al. (1997) Electrophoresis 18:1184-1192] 참조))을 이용할 수 있다. 이러한 기술들을 사용하여, 본원에서 제공되는 단백질 서열을 코리네박테리움 글루타미쿰 단백질 확인에 사용할 수 있다.
상기 방법으로 얻은 정보를 사용하여 각종 생물학적 조건 (예를 들면, 상이한 생물, 발효 시점, 배지 조건, 또는 서로간의 상이한 환경 (biotope))으로부터의 상이한 샘플들 사이에서 단백질 존재 여부, 활성 또는 변형의 양상들을 비교할 수 있다. 상기 실험 단독으로 또는 다른 기술들과 병행하여 얻어진 데이타는 주어진 상태 (예를 들면, 대사 상태)에서 각종 생물의 반응 비교, 정밀 화학물질을 생성하는 균주의 생산성 증가, 또는 정밀 화학물질의 생성 효율 증가 등 여러가지 목적을 위해 적용할 수 있다.
등가법
당업자라면, 일상적인 실험 방법 뿐 아니라 본원에 기재한 본 발명의 특정 실시양태와 등가인 많은 실험 방법들을 알고 있거나, 알아낼 수 있을 것이다. 이러한 동등한 방법들은 하기의 청구항에 포함될 것이다.
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230 235 240 245
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Tyr Glu Glu Asn Gly Thr Tyr
250
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Met Thr Ala Gln Ile Asp Asp Ser Ile Leu Thr His Arg Leu Ala Gln
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Gly Thr Gly Glu Ile Leu Lys Gly Val Arg Asn Val Gly Val Leu Arg
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Gly Arg Asn Leu Gly Asp Ala Gly Asp Glu Leu Ala Gln Ser Trp Ile
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Ala Arg Val Leu Glu Gln His Arg Pro Asn Asp Gly Phe Leu Ser Glu
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Glu Ala Ala Asp Asn Pro Asp Arg Leu Ser Lys Asp Arg Val Trp Ile
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Ile Asp Pro Leu Asp Gly Thr Lys Glu Phe Ala Thr Gly Arg Gln Asp
85 90 95
Trp Ala Val His Ile Ala Leu Val Glu Asn Gly Val Pro Thr His Ala
100 105 110
Ala Val Gly Leu Pro Asp Leu Gly Val Val Phe His Ser Ala Asp Ala
115 120 125
Arg Ala Val Thr Gly Pro Tyr Ser Lys Val Ile Ala Ile Ser His Asn
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Arg Pro Pro Lys Val Ala Leu Ser Cys Ala Glu Gln Leu Gly Phe Glu
145 150 155 160
Thr Lys Ala Leu Gly Ser Ala Gly Ala Lys Ala Met His Val Leu Leu
165 170 175
Gly Asp Tyr Asp Ala Tyr Ile His Ala Gly Gly Gln Tyr Glu Trp Asp
180 185 190
Ser Ala Ala Pro Val Gly Val Cys Lys Ala Ala Gly Leu His Cys Ser
195 200 205
Arg Leu Asp Gly Ser Glu Leu Thr Tyr Asn Asn Lys Asp Thr Tyr Met
210 215 220
Pro Asp Ile Leu Ile Cys Arg Pro Glu Leu Ala Asp Glu Leu Leu Glu
225 230 235 240
Met Cys Ala Lys Phe Tyr Glu Glu Asn Gly Thr Tyr
245 250
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cgaagttcac gactacaggc attacctggg tgctgatttt gcgcgagtaa agctgtggct 60
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Thr Phe Pro Leu Phe Ile Pro Leu Val Arg Lys Val Lys Gly Val Gly
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Phe Val Pro Arg Leu Trp Asp Thr Asn Val Ser Pro Val Ala Glu Val
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His Ala Asp Pro Val Trp Phe Met Gln Glu Glu Ile Pro Val Leu Glu
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Ser Tyr Trp Leu Ser Tyr Tyr Phe Pro Leu Thr Arg Leu Ile Glu Phe
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Tyr Leu Gly Val Phe Gly Ala Lys Leu Val Ala Glu Gly Met Phe Lys
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Asn Thr Asn Ile Thr Ile Pro Leu Ile Ala Leu Ala Val Ser Phe Val
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150 155 160 165
ctg cca atg gct ttt gtt gtg gca acg ctt gcg gtg aga gac att gaa 643
Leu Pro Met Ala Phe Val Val Ala Thr Leu Ala Val Arg Asp Ile Glu
170 175 180
ggc aag agt ggg gaa atc gcc tcg cct cgc gca gtt ttg ttg ggt aat 691
Gly Lys Ser Gly Glu Ile Ala Ser Pro Arg Ala Val Leu Leu Gly Asn
185 190 195
att tcc ttt gcc ttc tac atg gtg caa ttc ccc gtc atg gtg ttt gtg 739
Ile Ser Phe Ala Phe Tyr Met Val Gln Phe Pro Val Met Val Phe Val
200 205 210
cag cgc tat ttc att gct ggc aaa gaa tac ggc ttc ctt ggc tgg gca 787
Gln Arg Tyr Phe Ile Ala Gly Lys Glu Tyr Gly Phe Leu Gly Trp Ala
215 220 225
ttc tat gca gtg gtg tgt ttc atc gtg tcg gtc att ctc gcg tgg gtg 835
Phe Tyr Ala Val Val Cys Phe Ile Val Ser Val Ile Leu Ala Trp Val
230 235 240 245
ctg tta cct tcg ttg atg atc ctt taataaggcc acggaa 875
Leu Leu Pro Ser Leu Met Ile Leu
250
<210> 8
<211> 253
<212> PRT
<213> Corynebacterium glutamicum
<400> 8
Val Thr Leu Gly Gly Leu Asn Val Pro Ser Trp Ser Leu Gly Ala Glu
1 5 10 15
Met Leu Phe Tyr Leu Thr Phe Pro Leu Phe Ile Pro Leu Val Arg Lys
20 25 30
Val Lys Gly Val Gly Asn Trp Trp Ala Phe Gly Ile Thr Phe Ala Val
35 40 45
Ser Leu Ala Leu Ile Thr Val Ile His Phe Tyr Ala Asp Gly Pro Lys
50 55 60
Gly Ile Glu Asn Phe Phe Val Pro Arg Leu Trp Asp Thr Asn Val Ser
65 70 75 80
Pro Val Ala Glu Val His Ala Asp Pro Val Trp Phe Met Gln Glu Glu
85 90 95
Ile Pro Val Leu Glu Ser Tyr Trp Leu Ser Tyr Tyr Phe Pro Leu Thr
100 105 110
Arg Leu Ile Glu Phe Tyr Leu Gly Val Phe Gly Ala Lys Leu Val Ala
115 120 125
Glu Gly Met Phe Lys Asn Thr Asn Ile Thr Ile Pro Leu Ile Ala Leu
130 135 140
Ala Val Ser Phe Val Ala Thr Trp Phe Val Pro Leu Ala Phe Lys Met
145 150 155 160
Ser Val Ile Met Ser Leu Pro Met Ala Phe Val Val Ala Thr Leu Ala
165 170 175
Val Arg Asp Ile Glu Gly Lys Ser Gly Glu Ile Ala Ser Pro Arg Ala
180 185 190
Val Leu Leu Gly Asn Ile Ser Phe Ala Phe Tyr Met Val Gln Phe Pro
195 200 205
Val Met Val Phe Val Gln Arg Tyr Phe Ile Ala Gly Lys Glu Tyr Gly
210 215 220
Phe Leu Gly Trp Ala Phe Tyr Ala Val Val Cys Phe Ile Val Ser Val
225 230 235 240
Ile Leu Ala Trp Val Leu Leu Pro Ser Leu Met Ile Leu
245 250
<210> 9
<211> 1983
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1960)
<223> RXN02581
<400> 9
acggtcactc gctcaagtag tgttagtttg caaaagtaat aaaatgttca tctttgtcga 60
tggtcacaat agtcattaaa gaattgtaag aggggttcac atg gat tta gat aaa 115
Met Asp Leu Asp Lys
1 5
gcg att ggt tca ttc ttc gat gag aat gga gaa atc aac ctt cct cca 163
Ala Ile Gly Ser Phe Phe Asp Glu Asn Gly Glu Ile Asn Leu Pro Pro
10 15 20
ttc cta act ttg gca gcc atg ggt gag ttc atg tac cag gct gac atc 211
Phe Leu Thr Leu Ala Ala Met Gly Glu Phe Met Tyr Gln Ala Asp Ile
25 30 35
gct gaa ggc ggc ggg gat aaa cca cgc atg cat ttc tgg gac ttc tcc 259
Ala Glu Gly Gly Gly Asp Lys Pro Arg Met His Phe Trp Asp Phe Ser
40 45 50
gaa gac cgc gat ggc aag ctg att cag tac acc cga aac gag atc gat 307
Glu Asp Arg Asp Gly Lys Leu Ile Gln Tyr Thr Arg Asn Glu Ile Asp
55 60 65
act cgt atc aag gct gta gca ggc cgt ttg cag cag gtc gcc acc ctg 355
Thr Arg Ile Lys Ala Val Ala Gly Arg Leu Gln Gln Val Ala Thr Leu
70 75 80 85
ggt gat cgt gca gcg atc ctg gct aac aac agc cct gag tac att ttc 403
Gly Asp Arg Ala Ala Ile Leu Ala Asn Asn Ser Pro Glu Tyr Ile Phe
90 95 100
agc ttc ctc ggc gcg atc tac gct ggc atg gtc cct gtg ccg ctt tat 451
Ser Phe Leu Gly Ala Ile Tyr Ala Gly Met Val Pro Val Pro Leu Tyr
105 110 115
gat cca aac gag cca gga cac gca gac cac ctc aac gct gtt ttc gca 499
Asp Pro Asn Glu Pro Gly His Ala Asp His Leu Asn Ala Val Phe Ala
120 125 130
gac agc gag cca gtt gtc gtt ctg acc aac tcc aag tcc gca ggt gcc 547
Asp Ser Glu Pro Val Val Val Leu Thr Asn Ser Lys Ser Ala Gly Ala
135 140 145
gtg cgc aag cac ttc tcc agc ctt cca gct gca gaa cgc cca cgc atc 595
Val Arg Lys His Phe Ser Ser Leu Pro Ala Ala Glu Arg Pro Arg Ile
150 155 160 165
ctc tct gta gat tcc ttg cct gat tct ctc gcg gat tct tac gag aac 643
Leu Ser Val Asp Ser Leu Pro Asp Ser Leu Ala Asp Ser Tyr Glu Asn
170 175 180
cca atg ctg acc gaa gcc ggc cgc cgc ctg gct gct ctg cgc cag tcc 691
Pro Met Leu Thr Glu Ala Gly Arg Arg Leu Ala Ala Leu Arg Gln Ser
185 190 195
gcg ccc att gat ctg acc gca ttc ctg cag tac acc tcc ggc tcc acc 739
Ala Pro Ile Asp Leu Thr Ala Phe Leu Gln Tyr Thr Ser Gly Ser Thr
200 205 210
cga acc cca gct ggc gtt gtt ctg acc aac cgc tcc atc ctg acc aac 787
Arg Thr Pro Ala Gly Val Val Leu Thr Asn Arg Ser Ile Leu Thr Asn
215 220 225
gtc ttg cag atc ttc agc gcc gca cag ctg aaa acc cca ctg cgc ctg 835
Val Leu Gln Ile Phe Ser Ala Ala Gln Leu Lys Thr Pro Leu Arg Leu
230 235 240 245
gtt tca tgg ctg cca ctg cac cac gac atg ggc att atc ctc gcg gcg 883
Val Ser Trp Leu Pro Leu His His Asp Met Gly Ile Ile Leu Ala Ala
250 255 260
ttt gtc act atg ctt ggc ctg gac aac gag ttc atg aac cca cgc gat 931
Phe Val Thr Met Leu Gly Leu Asp Asn Glu Phe Met Asn Pro Arg Asp
265 270 275
ttc gtg cag cag cct tcc cgc tgg att aag cag ctc aac cgt cgc gaa 979
Phe Val Gln Gln Pro Ser Arg Trp Ile Lys Gln Leu Asn Arg Arg Glu
280 285 290
agc gac gtg gac gtt aac gtc tac acc gtg gtt cct aac ttc gcc ctc 1027
Ser Asp Val Asp Val Asn Val Tyr Thr Val Val Pro Asn Phe Ala Leu
295 300 305
gag ctt gca gca cgc tac gca aag cca gca gag gga gag acc ctg gat 1075
Glu Leu Ala Ala Arg Tyr Ala Lys Pro Ala Glu Gly Glu Thr Leu Asp
310 315 320 325
ctt tcc gca ttg gat gcc atc att atc ggt tcc gag cca gtc aca gaa 1123
Leu Ser Ala Leu Asp Ala Ile Ile Ile Gly Ser Glu Pro Val Thr Glu
330 335 340
aac gct ctg acc acc ttc cgt gaa gct ttc gag cct tac ggc ctg cct 1171
Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe Glu Pro Tyr Gly Leu Pro
345 350 355
gtt cag acc ctg cgt cct tcc tac ggt ctt gca gaa gca tcc ctg ctg 1219
Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu Ala Glu Ala Ser Leu Leu
360 365 370
gtc acc acc cca cag acc gaa aac cgc cca ctg atc tcc tac ttc gac 1267
Val Thr Thr Pro Gln Thr Glu Asn Arg Pro Leu Ile Ser Tyr Phe Asp
375 380 385
cgc gag gcc ttg gcc gaa aac cgc gtt gag ctt gta gaa aag ggc aat 1315
Arg Glu Ala Leu Ala Glu Asn Arg Val Glu Leu Val Glu Lys Gly Asn
390 395 400 405
aac aag gct gtt gct ttc gtc tcc aac ggc cag gtt gca gcc cca cag 1363
Asn Lys Ala Val Ala Phe Val Ser Asn Gly Gln Val Ala Ala Pro Gln
410 415 420
cag ctg gtc atc gtt gat tcc gaa acc gga acc gag ctg gca gac ggc 1411
Gln Leu Val Ile Val Asp Ser Glu Thr Gly Thr Glu Leu Ala Asp Gly
425 430 435
cag atc ggc gaa atc tgg acc cac ggc gaa aac act gct gca ggt tac 1459
Gln Ile Gly Glu Ile Trp Thr His Gly Glu Asn Thr Ala Ala Gly Tyr
440 445 450
ctc gac cgc gag gaa gac acc gca gaa acc ttc cgc aac cgt ctg acc 1507
Leu Asp Arg Glu Glu Asp Thr Ala Glu Thr Phe Arg Asn Arg Leu Thr
455 460 465
acc cgc ctg gaa gaa aac tcc cgc gca gaa ggt gct gcc gac gac aac 1555
Thr Arg Leu Glu Glu Asn Ser Arg Ala Glu Gly Ala Ala Asp Asp Asn
470 475 480 485
tac tgg atg gcc acc ggt gac ctc ggc gtc atc gta gac aac gag ctc 1603
Tyr Trp Met Ala Thr Gly Asp Leu Gly Val Ile Val Asp Asn Glu Leu
490 495 500
tac atc acc ggt cgt ctg aag gac ctc atc gtt gtc gca ggc cga aac 1651
Tyr Ile Thr Gly Arg Leu Lys Asp Leu Ile Val Val Ala Gly Arg Asn
505 510 515
cac tac cca cag gac atc gag tac acc gtc cag gct gct tcc gca cac 1699
His Tyr Pro Gln Asp Ile Glu Tyr Thr Val Gln Ala Ala Ser Ala His
520 525 530
atc cgt gca gat tcc gtc gca gca ttc gca gtc cca ggc gat gac att 1747
Ile Arg Ala Asp Ser Val Ala Ala Phe Ala Val Pro Gly Asp Asp Ile
535 540 545
gaa aag ctc atc atc ctg gca gaa cgc gac acc act gca aac gaa gcc 1795
Glu Lys Leu Ile Ile Leu Ala Glu Arg Asp Thr Thr Ala Asn Glu Ala
550 555 560 565
gac gat gca gct gct gaa gaa gca atc cgc tcc gcc gtt ggc act gca 1843
Asp Asp Ala Ala Ala Glu Glu Ala Ile Arg Ser Ala Val Gly Thr Ala
570 575 580
cac ggt gtt gtt cca gaa gag atc cgt atc ctc gca cct gac gag atc 1891
His Gly Val Val Pro Glu Glu Ile Arg Ile Leu Ala Pro Asp Glu Ile
585 590 595
gcg cgt tcc tcc tcc gga aag atc gca cgc cgc gtc aac cag cgc aac 1939
Ala Arg Ser Ser Ser Gly Lys Ile Ala Arg Arg Val Asn Gln Arg Asn
600 605 610
tac att cag gaa caa gct aac tagttctttg cagacaccgc agg 1983
Tyr Ile Gln Glu Gln Ala Asn
615 620
<210> 10
<211> 620
<212> PRT
<213> Corynebacterium glutamicum
<400> 10
Met Asp Leu Asp Lys Ala Ile Gly Ser Phe Phe Asp Glu Asn Gly Glu
1 5 10 15
Ile Asn Leu Pro Pro Phe Leu Thr Leu Ala Ala Met Gly Glu Phe Met
20 25 30
Tyr Gln Ala Asp Ile Ala Glu Gly Gly Gly Asp Lys Pro Arg Met His
35 40 45
Phe Trp Asp Phe Ser Glu Asp Arg Asp Gly Lys Leu Ile Gln Tyr Thr
50 55 60
Arg Asn Glu Ile Asp Thr Arg Ile Lys Ala Val Ala Gly Arg Leu Gln
65 70 75 80
Gln Val Ala Thr Leu Gly Asp Arg Ala Ala Ile Leu Ala Asn Asn Ser
85 90 95
Pro Glu Tyr Ile Phe Ser Phe Leu Gly Ala Ile Tyr Ala Gly Met Val
100 105 110
Pro Val Pro Leu Tyr Asp Pro Asn Glu Pro Gly His Ala Asp His Leu
115 120 125
Asn Ala Val Phe Ala Asp Ser Glu Pro Val Val Val Leu Thr Asn Ser
130 135 140
Lys Ser Ala Gly Ala Val Arg Lys His Phe Ser Ser Leu Pro Ala Ala
145 150 155 160
Glu Arg Pro Arg Ile Leu Ser Val Asp Ser Leu Pro Asp Ser Leu Ala
165 170 175
Asp Ser Tyr Glu Asn Pro Met Leu Thr Glu Ala Gly Arg Arg Leu Ala
180 185 190
Ala Leu Arg Gln Ser Ala Pro Ile Asp Leu Thr Ala Phe Leu Gln Tyr
195 200 205
Thr Ser Gly Ser Thr Arg Thr Pro Ala Gly Val Val Leu Thr Asn Arg
210 215 220
Ser Ile Leu Thr Asn Val Leu Gln Ile Phe Ser Ala Ala Gln Leu Lys
225 230 235 240
Thr Pro Leu Arg Leu Val Ser Trp Leu Pro Leu His His Asp Met Gly
245 250 255
Ile Ile Leu Ala Ala Phe Val Thr Met Leu Gly Leu Asp Asn Glu Phe
260 265 270
Met Asn Pro Arg Asp Phe Val Gln Gln Pro Ser Arg Trp Ile Lys Gln
275 280 285
Leu Asn Arg Arg Glu Ser Asp Val Asp Val Asn Val Tyr Thr Val Val
290 295 300
Pro Asn Phe Ala Leu Glu Leu Ala Ala Arg Tyr Ala Lys Pro Ala Glu
305 310 315 320
Gly Glu Thr Leu Asp Leu Ser Ala Leu Asp Ala Ile Ile Ile Gly Ser
325 330 335
Glu Pro Val Thr Glu Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe Glu
340 345 350
Pro Tyr Gly Leu Pro Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu Ala
355 360 365
Glu Ala Ser Leu Leu Val Thr Thr Pro Gln Thr Glu Asn Arg Pro Leu
370 375 380
Ile Ser Tyr Phe Asp Arg Glu Ala Leu Ala Glu Asn Arg Val Glu Leu
385 390 395 400
Val Glu Lys Gly Asn Asn Lys Ala Val Ala Phe Val Ser Asn Gly Gln
405 410 415
Val Ala Ala Pro Gln Gln Leu Val Ile Val Asp Ser Glu Thr Gly Thr
420 425 430
Glu Leu Ala Asp Gly Gln Ile Gly Glu Ile Trp Thr His Gly Glu Asn
435 440 445
Thr Ala Ala Gly Tyr Leu Asp Arg Glu Glu Asp Thr Ala Glu Thr Phe
450 455 460
Arg Asn Arg Leu Thr Thr Arg Leu Glu Glu Asn Ser Arg Ala Glu Gly
465 470 475 480
Ala Ala Asp Asp Asn Tyr Trp Met Ala Thr Gly Asp Leu Gly Val Ile
485 490 495
Val Asp Asn Glu Leu Tyr Ile Thr Gly Arg Leu Lys Asp Leu Ile Val
500 505 510
Val Ala Gly Arg Asn His Tyr Pro Gln Asp Ile Glu Tyr Thr Val Gln
515 520 525
Ala Ala Ser Ala His Ile Arg Ala Asp Ser Val Ala Ala Phe Ala Val
530 535 540
Pro Gly Asp Asp Ile Glu Lys Leu Ile Ile Leu Ala Glu Arg Asp Thr
545 550 555 560
Thr Ala Asn Glu Ala Asp Asp Ala Ala Ala Glu Glu Ala Ile Arg Ser
565 570 575
Ala Val Gly Thr Ala His Gly Val Val Pro Glu Glu Ile Arg Ile Leu
580 585 590
Ala Pro Asp Glu Ile Ala Arg Ser Ser Ser Gly Lys Ile Ala Arg Arg
595 600 605
Val Asn Gln Arg Asn Tyr Ile Gln Glu Gln Ala Asn
610 615 620
<210> 11
<211> 1550
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(1527)
<223> FRXA02581
<400> 11
gtc cct gtg ccg ctt tat gat cca aac gag cca gga cac gca gac cac 48
Val Pro Val Pro Leu Tyr Asp Pro Asn Glu Pro Gly His Ala Asp His
1 5 10 15
ctc aac gct gtt ttc gca gac agc gag cca gtt gtc gtt ctg acc aac 96
Leu Asn Ala Val Phe Ala Asp Ser Glu Pro Val Val Val Leu Thr Asn
20 25 30
tcc aag tcc gca ggt gcc gtg cgc aag cac ttc tcc agc ctt cca gct 144
Ser Lys Ser Ala Gly Ala Val Arg Lys His Phe Ser Ser Leu Pro Ala
35 40 45
gca gaa cgc cca cgc atc ctc tct gta gat tcc ttg cct gat tct ctc 192
Ala Glu Arg Pro Arg Ile Leu Ser Val Asp Ser Leu Pro Asp Ser Leu
50 55 60
gcg gat tct tac gag aac cca atg ctg acc gaa gcc ggc cgc cgc ctg 240
Ala Asp Ser Tyr Glu Asn Pro Met Leu Thr Glu Ala Gly Arg Arg Leu
65 70 75 80
gct gct ctg cgc cag tcc gcg ccc att gat ctg acc gca ttc ctg cag 288
Ala Ala Leu Arg Gln Ser Ala Pro Ile Asp Leu Thr Ala Phe Leu Gln
85 90 95
tac acc tcc ggc tcc acc cga acc cca gct ggc gtt gtt ctg acc aac 336
Tyr Thr Ser Gly Ser Thr Arg Thr Pro Ala Gly Val Val Leu Thr Asn
100 105 110
cgc tcc atc ctg acc aac gtc ttg cag atc ttc agc gcc gca cag ctg 384
Arg Ser Ile Leu Thr Asn Val Leu Gln Ile Phe Ser Ala Ala Gln Leu
115 120 125
aaa acc cca ctg cgc ctg gtt tca tgg ctg cca ctg cac cac gac atg 432
Lys Thr Pro Leu Arg Leu Val Ser Trp Leu Pro Leu His His Asp Met
130 135 140
ggc att atc ctc gcg gcg ttt gtc act atg ctt ggc ctg gac aac gag 480
Gly Ile Ile Leu Ala Ala Phe Val Thr Met Leu Gly Leu Asp Asn Glu
145 150 155 160
ttc atg aac cca cgc gat ttc gtg cag cag cct tcc cgc tgg att aag 528
Phe Met Asn Pro Arg Asp Phe Val Gln Gln Pro Ser Arg Trp Ile Lys
165 170 175
cag ctc aac cgt cgc gaa agc gac gtg gac gtt aac gtc tac acc gtg 576
Gln Leu Asn Arg Arg Glu Ser Asp Val Asp Val Asn Val Tyr Thr Val
180 185 190
gtt cct aac ttc gcc ctc gag ctt gca gca cgc tac gca aag cca gca 624
Val Pro Asn Phe Ala Leu Glu Leu Ala Ala Arg Tyr Ala Lys Pro Ala
195 200 205
gag gga gag acc ctg gat ctt tcc gca ttg gat gcc atc att atc ggt 672
Glu Gly Glu Thr Leu Asp Leu Ser Ala Leu Asp Ala Ile Ile Ile Gly
210 215 220
tcc gag cca gtc aca gaa aac gct ctg acc acc ttc cgt gaa gct ttc 720
Ser Glu Pro Val Thr Glu Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe
225 230 235 240
gag cct tac ggc ctg cct gtt cag acc ctg cgt cct tcc tac ggt ctt 768
Glu Pro Tyr Gly Leu Pro Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu
245 250 255
gca gaa gca tcc ctg ctg gtc acc acc cca cag acc gaa aac cgc cca 816
Ala Glu Ala Ser Leu Leu Val Thr Thr Pro Gln Thr Glu Asn Arg Pro
260 265 270
ctg atc tcc tac ttc gac cgc gag gcc ttg gcc gaa aac cgc gtt gag 864
Leu Ile Ser Tyr Phe Asp Arg Glu Ala Leu Ala Glu Asn Arg Val Glu
275 280 285
ctt gta gaa aag ggc aat aac aag gct gtt gct ttc gtc tcc aac ggc 912
Leu Val Glu Lys Gly Asn Asn Lys Ala Val Ala Phe Val Ser Asn Gly
290 295 300
cag gtt gca gcc cca cag cag ctg gtc atc gtt gat tcc gaa acc gga 960
Gln Val Ala Ala Pro Gln Gln Leu Val Ile Val Asp Ser Glu Thr Gly
305 310 315 320
acc gag ctg gca gac ggc cag atc ggc gaa atc tgg acc cac ggc gaa 1008
Thr Glu Leu Ala Asp Gly Gln Ile Gly Glu Ile Trp Thr His Gly Glu
325 330 335
aac act gct gca ggt tac ctc gac cgc gag gaa gac acc gca gaa acc 1056
Asn Thr Ala Ala Gly Tyr Leu Asp Arg Glu Glu Asp Thr Ala Glu Thr
340 345 350
ttc cgc aac cgt ctg acc acc cgc ctg gaa gaa aac tcc cgc gca gaa 1104
Phe Arg Asn Arg Leu Thr Thr Arg Leu Glu Glu Asn Ser Arg Ala Glu
355 360 365
ggt gct gcc gac gac aac tac tgg atg gcc acc ggt gac ctc ggc gtc 1152
Gly Ala Ala Asp Asp Asn Tyr Trp Met Ala Thr Gly Asp Leu Gly Val
370 375 380
atc gta gac aac gag ctc tac atc acc ggt cgt ctg aag gac ctc atc 1200
Ile Val Asp Asn Glu Leu Tyr Ile Thr Gly Arg Leu Lys Asp Leu Ile
385 390 395 400
gtt gtc gca ggc cga aac cac tac cca cag gac atc gag tac acc gtc 1248
Val Val Ala Gly Arg Asn His Tyr Pro Gln Asp Ile Glu Tyr Thr Val
405 410 415
cag gct gct tcc gca cac atc cgt gca gat tcc gtc gca gca ttc gca 1296
Gln Ala Ala Ser Ala His Ile Arg Ala Asp Ser Val Ala Ala Phe Ala
420 425 430
gtc cca ggc gat gac att gaa aag ctc atc atc ctg gca gaa cgc gac 1344
Val Pro Gly Asp Asp Ile Glu Lys Leu Ile Ile Leu Ala Glu Arg Asp
435 440 445
acc act gca aac gaa gcc gac gat gca gct gct gaa gaa gca atc cgc 1392
Thr Thr Ala Asn Glu Ala Asp Asp Ala Ala Ala Glu Glu Ala Ile Arg
450 455 460
tcc gcc gtt ggc act gca cac ggt gtt gtt cca gaa gag atc cgt atc 1440
Ser Ala Val Gly Thr Ala His Gly Val Val Pro Glu Glu Ile Arg Ile
465 470 475 480
ctc gca cct gac gag atc gcg cgt tcc tcc tcc gga aag atc gca cgc 1488
Leu Ala Pro Asp Glu Ile Ala Arg Ser Ser Ser Gly Lys Ile Ala Arg
485 490 495
cgc gtc aac cag cgc aac tac att cag gaa caa gct aac tagttctttg 1537
Arg Val Asn Gln Arg Asn Tyr Ile Gln Glu Gln Ala Asn
500 505
cagacaccgc agg 1550
<210> 12
<211> 509
<212> PRT
<213> Corynebacterium glutamicum
<400> 12
Val Pro Val Pro Leu Tyr Asp Pro Asn Glu Pro Gly His Ala Asp His
1 5 10 15
Leu Asn Ala Val Phe Ala Asp Ser Glu Pro Val Val Val Leu Thr Asn
20 25 30
Ser Lys Ser Ala Gly Ala Val Arg Lys His Phe Ser Ser Leu Pro Ala
35 40 45
Ala Glu Arg Pro Arg Ile Leu Ser Val Asp Ser Leu Pro Asp Ser Leu
50 55 60
Ala Asp Ser Tyr Glu Asn Pro Met Leu Thr Glu Ala Gly Arg Arg Leu
65 70 75 80
Ala Ala Leu Arg Gln Ser Ala Pro Ile Asp Leu Thr Ala Phe Leu Gln
85 90 95
Tyr Thr Ser Gly Ser Thr Arg Thr Pro Ala Gly Val Val Leu Thr Asn
100 105 110
Arg Ser Ile Leu Thr Asn Val Leu Gln Ile Phe Ser Ala Ala Gln Leu
115 120 125
Lys Thr Pro Leu Arg Leu Val Ser Trp Leu Pro Leu His His Asp Met
130 135 140
Gly Ile Ile Leu Ala Ala Phe Val Thr Met Leu Gly Leu Asp Asn Glu
145 150 155 160
Phe Met Asn Pro Arg Asp Phe Val Gln Gln Pro Ser Arg Trp Ile Lys
165 170 175
Gln Leu Asn Arg Arg Glu Ser Asp Val Asp Val Asn Val Tyr Thr Val
180 185 190
Val Pro Asn Phe Ala Leu Glu Leu Ala Ala Arg Tyr Ala Lys Pro Ala
195 200 205
Glu Gly Glu Thr Leu Asp Leu Ser Ala Leu Asp Ala Ile Ile Ile Gly
210 215 220
Ser Glu Pro Val Thr Glu Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe
225 230 235 240
Glu Pro Tyr Gly Leu Pro Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu
245 250 255
Ala Glu Ala Ser Leu Leu Val Thr Thr Pro Gln Thr Glu Asn Arg Pro
260 265 270
Leu Ile Ser Tyr Phe Asp Arg Glu Ala Leu Ala Glu Asn Arg Val Glu
275 280 285
Leu Val Glu Lys Gly Asn Asn Lys Ala Val Ala Phe Val Ser Asn Gly
290 295 300
Gln Val Ala Ala Pro Gln Gln Leu Val Ile Val Asp Ser Glu Thr Gly
305 310 315 320
Thr Glu Leu Ala Asp Gly Gln Ile Gly Glu Ile Trp Thr His Gly Glu
325 330 335
Asn Thr Ala Ala Gly Tyr Leu Asp Arg Glu Glu Asp Thr Ala Glu Thr
340 345 350
Phe Arg Asn Arg Leu Thr Thr Arg Leu Glu Glu Asn Ser Arg Ala Glu
355 360 365
Gly Ala Ala Asp Asp Asn Tyr Trp Met Ala Thr Gly Asp Leu Gly Val
370 375 380
Ile Val Asp Asn Glu Leu Tyr Ile Thr Gly Arg Leu Lys Asp Leu Ile
385 390 395 400
Val Val Ala Gly Arg Asn His Tyr Pro Gln Asp Ile Glu Tyr Thr Val
405 410 415
Gln Ala Ala Ser Ala His Ile Arg Ala Asp Ser Val Ala Ala Phe Ala
420 425 430
Val Pro Gly Asp Asp Ile Glu Lys Leu Ile Ile Leu Ala Glu Arg Asp
435 440 445
Thr Thr Ala Asn Glu Ala Asp Asp Ala Ala Ala Glu Glu Ala Ile Arg
450 455 460
Ser Ala Val Gly Thr Ala His Gly Val Val Pro Glu Glu Ile Arg Ile
465 470 475 480
Leu Ala Pro Asp Glu Ile Ala Arg Ser Ser Ser Gly Lys Ile Ala Arg
485 490 495
Arg Val Asn Gln Arg Asn Tyr Ile Gln Glu Gln Ala Asn
500 505
<210> 13
<211> 4953
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(4930)
<223> RXA02582
<400> 13
tggatgtcta ttctcctcag cctcgttttg gttgaggcgg atagttttaa tattttttta 60
agtttaagtt gtaatcgagc tgaaaggctg aggcctcaat atg gaa cag agc caa 115
Met Glu Gln Ser Gln
1 5
tcg tcg gat cag aag atg acc gtt gaa cag gtt cgc acc tgg ctc cgt 163
Ser Ser Asp Gln Lys Met Thr Val Glu Gln Val Arg Thr Trp Leu Arg
10 15 20
gat tgg gtt gtc cgc acc acg ggt att ccg gtg gag gaa gtt acg gat 211
Asp Trp Val Val Arg Thr Thr Gly Ile Pro Val Glu Glu Val Thr Asp
25 30 35
gac aag gca atg gag acc ttt ggc ctt tcc tct cgc gat gtt gtt gtg 259
Asp Lys Ala Met Glu Thr Phe Gly Leu Ser Ser Arg Asp Val Val Val
40 45 50
ttg tct ggt gag ctg gaa aac ctg ctg gac acc tcc ttg gat gcc acc 307
Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr Ser Leu Asp Ala Thr
55 60 65
atc gct tat gag tac cca acg atc cgt agt ttg gcg cag cgc ctt gtt 355
Ile Ala Tyr Glu Tyr Pro Thr Ile Arg Ser Leu Ala Gln Arg Leu Val
70 75 80 85
gag ggc gag cct cgt cgt gca cat acc cag cgt gaa ttg aat ttc tcc 403
Glu Gly Glu Pro Arg Arg Ala His Thr Gln Arg Glu Leu Asn Phe Ser
90 95 100
gcg gtg agc gat tcc cca ggt tcc cac gat att gcg gtt gtc ggt atg 451
Ala Val Ser Asp Ser Pro Gly Ser His Asp Ile Ala Val Val Gly Met
105 110 115
gct gcg cgt tac cca ggc gct gag agc ctg gag gat atg tgg aag cta 499
Ala Ala Arg Tyr Pro Gly Ala Glu Ser Leu Glu Asp Met Trp Lys Leu
120 125 130
ctc gtc gag ggc cgt gac ggt atc tcg gat cta ccg att ggc cgt tgg 547
Leu Val Glu Gly Arg Asp Gly Ile Ser Asp Leu Pro Ile Gly Arg Trp
135 140 145
tct gag tat gca ggc gat gag gtt atg tct cgg aag atg gaa gag ttt 595
Ser Glu Tyr Ala Gly Asp Glu Val Met Ser Arg Lys Met Glu Glu Phe
150 155 160 165
tct acc atc ggt ggc tac ctg tca gat atc tct agc ttt gat gcg gag 643
Ser Thr Ile Gly Gly Tyr Leu Ser Asp Ile Ser Ser Phe Asp Ala Glu
170 175 180
ttc ttt ggt ctg tct ccg ctc gag gcc gcc aac atg gat cct cag cag 691
Phe Phe Gly Leu Ser Pro Leu Glu Ala Ala Asn Met Asp Pro Gln Gln
185 190 195
cgt att ttg ctg gag cta acg tgg gag gct ttg gag tac gct cgc atc 739
Arg Ile Leu Leu Glu Leu Thr Trp Glu Ala Leu Glu Tyr Ala Arg Ile
200 205 210
gca cca aac act ttg cgt ggc gaa gcc gtg ggc gtg ttc ata ggt tcc 787
Ala Pro Asn Thr Leu Arg Gly Glu Ala Val Gly Val Phe Ile Gly Ser
215 220 225
tcc aac aac gat tac ggc atg atg atc gct gcc gat cca gca gaa gca 835
Ser Asn Asn Asp Tyr Gly Met Met Ile Ala Ala Asp Pro Ala Glu Ala
230 235 240 245
cat cct tat gcg ctg act ggt act tct agt gcg att gtc gct aac cgc 883
His Pro Tyr Ala Leu Thr Gly Thr Ser Ser Ala Ile Val Ala Asn Arg
250 255 260
att aac tac gct ttc gat ttc cgc ggt cct tcc gtc aac gtg gat acc 931
Ile Asn Tyr Ala Phe Asp Phe Arg Gly Pro Ser Val Asn Val Asp Thr
265 270 275
gca tgt tct tct tct ctg gta gcg gtt cac cag gct gtc cgt gcg ctg 979
Ala Cys Ser Ser Ser Leu Val Ala Val His Gln Ala Val Arg Ala Leu
280 285 290
cgt aat ggc gaa gcg gat cac gct atc gct ggt gga gtg aac att ttg 1027
Arg Asn Gly Glu Ala Asp His Ala Ile Ala Gly Gly Val Asn Ile Leu
295 300 305
gca tct cca ttt gtc aca act gca ttc gct gag ctc ggt gtg atc agc 1075
Ala Ser Pro Phe Val Thr Thr Ala Phe Ala Glu Leu Gly Val Ile Ser
310 315 320 325
cca acc ggc aag atc cac gca ttc tct gat gat gcc gat ggt ttc gtg 1123
Pro Thr Gly Lys Ile His Ala Phe Ser Asp Asp Ala Asp Gly Phe Val
330 335 340
cgt tcc gac ggc gcc gga gtc gtt gtg ctg aag cgc gtg gat gac gca 1171
Arg Ser Asp Gly Ala Gly Val Val Val Leu Lys Arg Val Asp Asp Ala
345 350 355
atc cgc gac ggc gac aag atc atc ggt gtg atc aag ggt tct gca gtg 1219
Ile Arg Asp Gly Asp Lys Ile Ile Gly Val Ile Lys Gly Ser Ala Val
360 365 370
aac tcc gat ggt cac tcc aac gga ctg acc gct cca aac cct gac gca 1267
Asn Ser Asp Gly His Ser Asn Gly Leu Thr Ala Pro Asn Pro Asp Ala
375 380 385
cag gtt gat gtg ctg cag cgt gca tat gtt gac gct cag gtt gat ccc 1315
Gln Val Asp Val Leu Gln Arg Ala Tyr Val Asp Ala Gln Val Asp Pro
390 395 400 405
acc acc gtg gat tac gtt gag gct cac ggc acc ggc acc atc ctg ggt 1363
Thr Thr Val Asp Tyr Val Glu Ala His Gly Thr Gly Thr Ile Leu Gly
410 415 420
gac ccc att gaa gca act gcc ctg ggt gct gtt ttg ggc tat ggc cgt 1411
Asp Pro Ile Glu Ala Thr Ala Leu Gly Ala Val Leu Gly Tyr Gly Arg
425 430 435
gac gca tcc acc cca act ctt ctg ggc tct gca aag tcc aac ttc ggc 1459
Asp Ala Ser Thr Pro Thr Leu Leu Gly Ser Ala Lys Ser Asn Phe Gly
440 445 450
cac act gag tca gct gcg ggt att gca ggt gtc atc aag gtg ctg ctt 1507
His Thr Glu Ser Ala Ala Gly Ile Ala Gly Val Ile Lys Val Leu Leu
455 460 465
gct ttg cag aac aag act ctg cca cca acc gtg aac ttt gca ggt cca 1555
Ala Leu Gln Asn Lys Thr Leu Pro Pro Thr Val Asn Phe Ala Gly Pro
470 475 480 485
aac cgc tac atc gat ttc gat gct gag cgt ttg gaa gtt gtg gaa gat 1603
Asn Arg Tyr Ile Asp Phe Asp Ala Glu Arg Leu Glu Val Val Glu Asp
490 495 500
cca cgt gaa tgg ccg gaa tac aac ggt cac gca gta gct ggt gtg tct 1651
Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Ala Val Ala Gly Val Ser
505 510 515
gcg ttc ggg ttc ggt gga acc aac gcg cac gtg gtg atc tct gag tac 1699
Ala Phe Gly Phe Gly Gly Thr Asn Ala His Val Val Ile Ser Glu Tyr
520 525 530
aac gca gaa gac tac gaa acc cgt gcc ccg aag gag gcg ttg ctt cct 1747
Asn Ala Glu Asp Tyr Glu Thr Arg Ala Pro Lys Glu Ala Leu Leu Pro
535 540 545
gac cag cag gtt gcc ctg ccg gtg tct ggt cac ctg cca tcc agg cgt 1795
Asp Gln Gln Val Ala Leu Pro Val Ser Gly His Leu Pro Ser Arg Arg
550 555 560 565
cga caa gca gct gct gac ttg gcg gac ttc ttg gag ggc cgc aaa gat 1843
Arg Gln Ala Ala Ala Asp Leu Ala Asp Phe Leu Glu Gly Arg Lys Asp
570 575 580
tgc gac cta acc cca gta gcc cgc gcg ctg gca ggc cgc aat cat ggc 1891
Cys Asp Leu Thr Pro Val Ala Arg Ala Leu Ala Gly Arg Asn His Gly
585 590 595
cgc tcc cgc gca gtc gtg ctt gca agc act atc gag gaa gcc gta aag 1939
Arg Ser Arg Ala Val Val Leu Ala Ser Thr Ile Glu Glu Ala Val Lys
600 605 610
cgc ctg cgc cag gtc gca gaa ggc aag gtc agc gtc ggt atc tcc gca 1987
Arg Leu Arg Gln Val Ala Glu Gly Lys Val Ser Val Gly Ile Ser Ala
615 620 625
gct gat tcc cca gcg gcc aac ggt cct gtg ttt gtg tac tcc ggt ttc 2035
Ala Asp Ser Pro Ala Ala Asn Gly Pro Val Phe Val Tyr Ser Gly Phe
630 635 640 645
gga tcc cag cac cgc ctc atg atc aag gaa ttg tgc tca att tcg cca 2083
Gly Ser Gln His Arg Leu Met Ile Lys Glu Leu Cys Ser Ile Ser Pro
650 655 660
cag ttc cgc gag cgc atc gaa gag ctc gat gaa atg gtt aag ttc gag 2131
Gln Phe Arg Glu Arg Ile Glu Glu Leu Asp Glu Met Val Lys Phe Glu
665 670 675
tcc ggc tgg tcc atc atg aaa ctt gtt ttg gat gat gag caa act tac 2179
Ser Gly Trp Ser Ile Met Lys Leu Val Leu Asp Asp Glu Gln Thr Tyr
680 685 690
gac acc gag acc gcg cag gtt gtg atc acc gca atc cag atc gca ctg 2227
Asp Thr Glu Thr Ala Gln Val Val Ile Thr Ala Ile Gln Ile Ala Leu
695 700 705
act gac ctg ttg gca agc ttc ggt gta aag cca gct gcc gtc atg ggc 2275
Thr Asp Leu Leu Ala Ser Phe Gly Val Lys Pro Ala Ala Val Met Gly
710 715 720 725
atg tcg atg ggt gag atc gct gcc gct tac gct gcc ggt gga ctc agc 2323
Met Ser Met Gly Glu Ile Ala Ala Ala Tyr Ala Ala Gly Gly Leu Ser
730 735 740
gac cgc gat acc atg ctc att gcc agc cac cgt tcc cgc cta atg ggc 2371
Asp Arg Asp Thr Met Leu Ile Ala Ser His Arg Ser Arg Leu Met Gly
745 750 755
gag ggc gag aag tcc ctg gct gag gat cag ctg ggt gcc atg gct gtg 2419
Glu Gly Glu Lys Ser Leu Ala Glu Asp Gln Leu Gly Ala Met Ala Val
760 765 770
gtg gaa ttc gcc gct gcg gac ctg gat aag ttc atc gaa gaa aac cct 2467
Val Glu Phe Ala Ala Ala Asp Leu Asp Lys Phe Ile Glu Glu Asn Pro
775 780 785
gag tac aag ggc att gag cct gct gtt tat gca ggc cca ggc atg act 2515
Glu Tyr Lys Gly Ile Glu Pro Ala Val Tyr Ala Gly Pro Gly Met Thr
790 795 800 805
acc gtg ggt gga cct cgc gac gcc gtg gtt cag ttc gta gag aag ctg 2563
Thr Val Gly Gly Pro Arg Asp Ala Val Val Gln Phe Val Glu Lys Leu
810 815 820
gaa tct gaa gac aag ttt gcc cgc ctg ctc aac gtc aag ggc gct ggc 2611
Glu Ser Glu Asp Lys Phe Ala Arg Leu Leu Asn Val Lys Gly Ala Gly
825 830 835
cac acc tct gct gtg gaa cca ctt ctt ggt gag ctc gct ggc gaa atc 2659
His Thr Ser Ala Val Glu Pro Leu Leu Gly Glu Leu Ala Gly Glu Ile
840 845 850
gct ggc atc gag cca ctt ccg ctg cag atc ccg ttg ttc agc tct gtc 2707
Ala Gly Ile Glu Pro Leu Pro Leu Gln Ile Pro Leu Phe Ser Ser Val
855 860 865
gat cag ggt gtt acc tac cca gtt gga gca gtg gtc cac gac gcc gat 2755
Asp Gln Gly Val Thr Tyr Pro Val Gly Ala Val Val His Asp Ala Asp
870 875 880 885
tac atg ctc cgc tgt acc cgc cag tcc gtg tac ttc cag gac tcc acc 2803
Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr Phe Gln Asp Ser Thr
890 895 900
gaa gct gca ttc gct gca ggc cac aac acc ttg gtg gaa att tcc ccg 2851
Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu Val Glu Ile Ser Pro
905 910 915
aac cca gtt gca ctc atg ggc atg atg aac acc gcg ttc acc gtg ggc 2899
Asn Pro Val Ala Leu Met Gly Met Met Asn Thr Ala Phe Thr Val Gly
920 925 930
aag cct gat gca cag ctg ctg ttc agc ctg aag cga aaa gtc cca gag 2947
Lys Pro Asp Ala Gln Leu Leu Phe Ser Leu Lys Arg Lys Val Pro Glu
935 940 945
gca gaa tcc ctc cgc gac ctt ctg gcg aag ctg tac gtc aac ggc gca 2995
Ala Glu Ser Leu Arg Asp Leu Leu Ala Lys Leu Tyr Val Asn Gly Ala
950 955 960 965
aac gtt gat ttc tcc gcg ctg tac ggc gaa ggt gaa acc atc gat ccg 3043
Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu Gly Glu Thr Ile Asp Pro
970 975 980
cca cac atc acc tgg aag cac cag cgc ttc tgg act tcc gca cgc cca 3091
Pro His Ile Thr Trp Lys His Gln Arg Phe Trp Thr Ser Ala Arg Pro
985 990 995
tcc tct ggc gca tcc ctg gat ctg ccg ggc ttc cgc gtg aat ctg cca 3139
Ser Ser Gly Ala Ser Leu Asp Leu Pro Gly Phe Arg Val Asn Leu Pro
1000 1005 1010
aac aac act gtg gcg ttt tcc acc gca gcc gaa ctg gca cca tcc gca 3187
Asn Asn Thr Val Ala Phe Ser Thr Ala Ala Glu Leu Ala Pro Ser Ala
1015 1020 1025
gtg gca atc atg gaa gca gcc gcc atg gct gtc acc cca ggt tcc tcc 3235
Val Ala Ile Met Glu Ala Ala Ala Met Ala Val Thr Pro Gly Ser Ser
1030 1035 1040 1045
gtc gac gca gtg gac gag cgc gac atg ctg cca cca agc ggc gaa atc 3283
Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro Pro Ser Gly Glu Ile
1050 1055 1060
acc acc atc gtg act cgc tcc ttg ggc ggt ttg agc ctg tcc gta tac 3331
Thr Thr Ile Val Thr Arg Ser Leu Gly Gly Leu Ser Leu Ser Val Tyr
1065 1070 1075
aag att gag gga acc acc agc act ctt gtc gcc gaa ggt ttc gca gcc 3379
Lys Ile Glu Gly Thr Thr Ser Thr Leu Val Ala Glu Gly Phe Ala Ala
1080 1085 1090
aac cca gga ttc gcc gca gca tct tcc ttc gac ggt cca ggc tac gac 3427
Asn Pro Gly Phe Ala Ala Ala Ser Ser Phe Asp Gly Pro Gly Tyr Asp
1095 1100 1105
gga ttc aac acc gat tac agc gac cag cca gac cct cgc tcc gac ctg 3475
Gly Phe Asn Thr Asp Tyr Ser Asp Gln Pro Asp Pro Arg Ser Asp Leu
1110 1115 1120 1125
cct ttg gac atc gaa gca gtc cgc tgg gac cca gcg acc gaa acc gtc 3523
Pro Leu Asp Ile Glu Ala Val Arg Trp Asp Pro Ala Thr Glu Thr Val
1130 1135 1140
gaa gag cgc atg cgc gcc atc gtc tcc gaa gca atg ggc tac gac gtg 3571
Glu Glu Arg Met Arg Ala Ile Val Ser Glu Ala Met Gly Tyr Asp Val
1145 1150 1155
gat gac ctc cca cgc gaa ctc cca ctg att gac ctc ggc ctc gac tcc 3619
Asp Asp Leu Pro Arg Glu Leu Pro Leu Ile Asp Leu Gly Leu Asp Ser
1160 1165 1170
ctc atg ggc atg cgc atc aaa aac cgc atc gaa aat gac ttc cag atc 3667
Leu Met Gly Met Arg Ile Lys Asn Arg Ile Glu Asn Asp Phe Gln Ile
1175 1180 1185
cca cca ctc cag gtc caa gcg ctc cgc gat gca tcc gtc gct gac gtg 3715
Pro Pro Leu Gln Val Gln Ala Leu Arg Asp Ala Ser Val Ala Asp Val
1190 1195 1200 1205
gta atc atg gtg gaa aac atg gtc gct ggc cgc tcc tct gag acg ctt 3763
Val Ile Met Val Glu Asn Met Val Ala Gly Arg Ser Ser Glu Thr Leu
1210 1215 1220
gtc gac gcc acc ccg cag gtg cca gct gag gca gca ggg gag gct caa 3811
Val Asp Ala Thr Pro Gln Val Pro Ala Glu Ala Ala Gly Glu Ala Gln
1225 1230 1235
gct gct gag tct tct gct tcg ggc gag gac gtg cag ggc gtt ggc gtt 3859
Ala Ala Glu Ser Ser Ala Ser Gly Glu Asp Val Gln Gly Val Gly Val
1240 1245 1250
gca ccg cga gat gcg tcg gaa cgc atg gtc ttt ggt act tgg gca ggc 3907
Ala Pro Arg Asp Ala Ser Glu Arg Met Val Phe Gly Thr Trp Ala Gly
1255 1260 1265
ctg act ggc gct gcg gca gct ggc gtg acc agc aag ttg cca cag atc 3955
Leu Thr Gly Ala Ala Ala Ala Gly Val Thr Ser Lys Leu Pro Gln Ile
1270 1275 1280 1285
gat gtc gat act gca acc gca att gcc gag cgc ctc acc gag cgt tcc 4003
Asp Val Asp Thr Ala Thr Ala Ile Ala Glu Arg Leu Thr Glu Arg Ser
1290 1295 1300
gga att gaa atc agc act gaa cag gtg ttg gct gca gaa acc ctc gaa 4051
Gly Ile Glu Ile Ser Thr Glu Gln Val Leu Ala Ala Glu Thr Leu Glu
1305 1310 1315
cca ctg tct gac ctg gtg cgt gaa ggc ctc gaa act gaa gtt cag ggc 4099
Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu Thr Glu Val Gln Gly
1320 1325 1330
aac att cgt gtg ctg cgt gga cgt gca gaa ggc tcc acc aag cct gca 4147
Asn Ile Arg Val Leu Arg Gly Arg Ala Glu Gly Ser Thr Lys Pro Ala
1335 1340 1345
gtg ttc atg ttc cac cca gct ggc ggt tct tcc gtg gtc tac caa cca 4195
Val Phe Met Phe His Pro Ala Gly Gly Ser Ser Val Val Tyr Gln Pro
1350 1355 1360 1365
cta atg cgt cgt ctg cct gaa gat gtc cct gtc tat ggc gtt gag cgt 4243
Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val Tyr Gly Val Glu Arg
1370 1375 1380
ctg gaa ggc gat ctc gct gac cgc gcg gca gca tat gtt gat gac atc 4291
Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala Tyr Val Asp Asp Ile
1385 1390 1395
aag aag tac tcc gat ggc ttc cca gta gtt ttg ggt ggc tgg agc ttc 4339
Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu Gly Gly Trp Ser Phe
1400 1405 1410
ggc ggt gcc gtt gcc ttc gag gtt gcc cac caa ctg gtt ggc tcc gat 4387
Gly Gly Ala Val Ala Phe Glu Val Ala His Gln Leu Val Gly Ser Asp
1415 1420 1425
gtt gag gta gct acc gtg gcg ttg ctg gat act gtg cag cct tca aac 4435
Val Glu Val Ala Thr Val Ala Leu Leu Asp Thr Val Gln Pro Ser Asn
1430 1435 1440 1445
cca gca cca gat acc gct gag gaa act cgt gca cgc tgg act cgc tac 4483
Pro Ala Pro Asp Thr Ala Glu Glu Thr Arg Ala Arg Trp Thr Arg Tyr
1450 1455 1460
gcg gac ttc gcc aag aag acc tac ggc ctt gat ttc gag gta cct ttt 4531
Ala Asp Phe Ala Lys Lys Thr Tyr Gly Leu Asp Phe Glu Val Pro Phe
1465 1470 1475
gaa atc ttg gac acc atc ggt gaa gac gga atg ctg tcc atg atg acc 4579
Glu Ile Leu Asp Thr Ile Gly Glu Asp Gly Met Leu Ser Met Met Thr
1480 1485 1490
gac ttc ctg gcc aac acc gac gcc tcc gag cac gga ttg tcc gca ggt 4627
Asp Phe Leu Ala Asn Thr Asp Ala Ser Glu His Gly Leu Ser Ala Gly
1495 1500 1505
gtg ctt gaa cac cag cgc gct tct ttt gtg gac aac cgc atc ctg gct 4675
Val Leu Glu His Gln Arg Ala Ser Phe Val Asp Asn Arg Ile Leu Ala
1510 1515 1520 1525
aaa ctt aat ttt gca gac tgg gcc aac gtt gaa gcc cct gtc atc ctg 4723
Lys Leu Asn Phe Ala Asp Trp Ala Asn Val Glu Ala Pro Val Ile Leu
1530 1535 1540
ttc cgc gcg gaa cgc atg cat gat gga gct atc gaa ctt gaa cca aac 4771
Phe Arg Ala Glu Arg Met His Asp Gly Ala Ile Glu Leu Glu Pro Asn
1545 1550 1555
tat gcc aag att gat caa gat gga gga tgg tcc gga att gtc aac gat 4819
Tyr Ala Lys Ile Asp Gln Asp Gly Gly Trp Ser Gly Ile Val Asn Asp
1560 1565 1570
ttg gaa att gtt cag ctg aat ggt gac cac ctg gca gtt gtc gat gaa 4867
Leu Glu Ile Val Gln Leu Asn Gly Asp His Leu Ala Val Val Asp Glu
1575 1580 1585
cca gaa atc ggc aca gtc gga gct cat ttg agt cgc cgc att gat gag 4915
Pro Glu Ile Gly Thr Val Gly Ala His Leu Ser Arg Arg Ile Asp Glu
1590 1595 1600 1605
att tct cgg aag aat tagtaacgga gagctgacgg aag 4953
Ile Ser Arg Lys Asn
1610
<210> 14
<211> 1610
<212> PRT
<213> Corynebacterium glutamicum
<400> 14
Met Glu Gln Ser Gln Ser Ser Asp Gln Lys Met Thr Val Glu Gln Val
1 5 10 15
Arg Thr Trp Leu Arg Asp Trp Val Val Arg Thr Thr Gly Ile Pro Val
20 25 30
Glu Glu Val Thr Asp Asp Lys Ala Met Glu Thr Phe Gly Leu Ser Ser
35 40 45
Arg Asp Val Val Val Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr
50 55 60
Ser Leu Asp Ala Thr Ile Ala Tyr Glu Tyr Pro Thr Ile Arg Ser Leu
65 70 75 80
Ala Gln Arg Leu Val Glu Gly Glu Pro Arg Arg Ala His Thr Gln Arg
85 90 95
Glu Leu Asn Phe Ser Ala Val Ser Asp Ser Pro Gly Ser His Asp Ile
100 105 110
Ala Val Val Gly Met Ala Ala Arg Tyr Pro Gly Ala Glu Ser Leu Glu
115 120 125
Asp Met Trp Lys Leu Leu Val Glu Gly Arg Asp Gly Ile Ser Asp Leu
130 135 140
Pro Ile Gly Arg Trp Ser Glu Tyr Ala Gly Asp Glu Val Met Ser Arg
145 150 155 160
Lys Met Glu Glu Phe Ser Thr Ile Gly Gly Tyr Leu Ser Asp Ile Ser
165 170 175
Ser Phe Asp Ala Glu Phe Phe Gly Leu Ser Pro Leu Glu Ala Ala Asn
180 185 190
Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Leu Thr Trp Glu Ala Leu
195 200 205
Glu Tyr Ala Arg Ile Ala Pro Asn Thr Leu Arg Gly Glu Ala Val Gly
210 215 220
Val Phe Ile Gly Ser Ser Asn Asn Asp Tyr Gly Met Met Ile Ala Ala
225 230 235 240
Asp Pro Ala Glu Ala His Pro Tyr Ala Leu Thr Gly Thr Ser Ser Ala
245 250 255
Ile Val Ala Asn Arg Ile Asn Tyr Ala Phe Asp Phe Arg Gly Pro Ser
260 265 270
Val Asn Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Val His Gln
275 280 285
Ala Val Arg Ala Leu Arg Asn Gly Glu Ala Asp His Ala Ile Ala Gly
290 295 300
Gly Val Asn Ile Leu Ala Ser Pro Phe Val Thr Thr Ala Phe Ala Glu
305 310 315 320
Leu Gly Val Ile Ser Pro Thr Gly Lys Ile His Ala Phe Ser Asp Asp
325 330 335
Ala Asp Gly Phe Val Arg Ser Asp Gly Ala Gly Val Val Val Leu Lys
340 345 350
Arg Val Asp Asp Ala Ile Arg Asp Gly Asp Lys Ile Ile Gly Val Ile
355 360 365
Lys Gly Ser Ala Val Asn Ser Asp Gly His Ser Asn Gly Leu Thr Ala
370 375 380
Pro Asn Pro Asp Ala Gln Val Asp Val Leu Gln Arg Ala Tyr Val Asp
385 390 395 400
Ala Gln Val Asp Pro Thr Thr Val Asp Tyr Val Glu Ala His Gly Thr
405 410 415
Gly Thr Ile Leu Gly Asp Pro Ile Glu Ala Thr Ala Leu Gly Ala Val
420 425 430
Leu Gly Tyr Gly Arg Asp Ala Ser Thr Pro Thr Leu Leu Gly Ser Ala
435 440 445
Lys Ser Asn Phe Gly His Thr Glu Ser Ala Ala Gly Ile Ala Gly Val
450 455 460
Ile Lys Val Leu Leu Ala Leu Gln Asn Lys Thr Leu Pro Pro Thr Val
465 470 475 480
Asn Phe Ala Gly Pro Asn Arg Tyr Ile Asp Phe Asp Ala Glu Arg Leu
485 490 495
Glu Val Val Glu Asp Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Ala
500 505 510
Val Ala Gly Val Ser Ala Phe Gly Phe Gly Gly Thr Asn Ala His Val
515 520 525
Val Ile Ser Glu Tyr Asn Ala Glu Asp Tyr Glu Thr Arg Ala Pro Lys
530 535 540
Glu Ala Leu Leu Pro Asp Gln Gln Val Ala Leu Pro Val Ser Gly His
545 550 555 560
Leu Pro Ser Arg Arg Arg Gln Ala Ala Ala Asp Leu Ala Asp Phe Leu
565 570 575
Glu Gly Arg Lys Asp Cys Asp Leu Thr Pro Val Ala Arg Ala Leu Ala
580 585 590
Gly Arg Asn His Gly Arg Ser Arg Ala Val Val Leu Ala Ser Thr Ile
595 600 605
Glu Glu Ala Val Lys Arg Leu Arg Gln Val Ala Glu Gly Lys Val Ser
610 615 620
Val Gly Ile Ser Ala Ala Asp Ser Pro Ala Ala Asn Gly Pro Val Phe
625 630 635 640
Val Tyr Ser Gly Phe Gly Ser Gln His Arg Leu Met Ile Lys Glu Leu
645 650 655
Cys Ser Ile Ser Pro Gln Phe Arg Glu Arg Ile Glu Glu Leu Asp Glu
660 665 670
Met Val Lys Phe Glu Ser Gly Trp Ser Ile Met Lys Leu Val Leu Asp
675 680 685
Asp Glu Gln Thr Tyr Asp Thr Glu Thr Ala Gln Val Val Ile Thr Ala
690 695 700
Ile Gln Ile Ala Leu Thr Asp Leu Leu Ala Ser Phe Gly Val Lys Pro
705 710 715 720
Ala Ala Val Met Gly Met Ser Met Gly Glu Ile Ala Ala Ala Tyr Ala
725 730 735
Ala Gly Gly Leu Ser Asp Arg Asp Thr Met Leu Ile Ala Ser His Arg
740 745 750
Ser Arg Leu Met Gly Glu Gly Glu Lys Ser Leu Ala Glu Asp Gln Leu
755 760 765
Gly Ala Met Ala Val Val Glu Phe Ala Ala Ala Asp Leu Asp Lys Phe
770 775 780
Ile Glu Glu Asn Pro Glu Tyr Lys Gly Ile Glu Pro Ala Val Tyr Ala
785 790 795 800
Gly Pro Gly Met Thr Thr Val Gly Gly Pro Arg Asp Ala Val Val Gln
805 810 815
Phe Val Glu Lys Leu Glu Ser Glu Asp Lys Phe Ala Arg Leu Leu Asn
820 825 830
Val Lys Gly Ala Gly His Thr Ser Ala Val Glu Pro Leu Leu Gly Glu
835 840 845
Leu Ala Gly Glu Ile Ala Gly Ile Glu Pro Leu Pro Leu Gln Ile Pro
850 855 860
Leu Phe Ser Ser Val Asp Gln Gly Val Thr Tyr Pro Val Gly Ala Val
865 870 875 880
Val His Asp Ala Asp Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr
885 890 895
Phe Gln Asp Ser Thr Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu
900 905 910
Val Glu Ile Ser Pro Asn Pro Val Ala Leu Met Gly Met Met Asn Thr
915 920 925
Ala Phe Thr Val Gly Lys Pro Asp Ala Gln Leu Leu Phe Ser Leu Lys
930 935 940
Arg Lys Val Pro Glu Ala Glu Ser Leu Arg Asp Leu Leu Ala Lys Leu
945 950 955 960
Tyr Val Asn Gly Ala Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu Gly
965 970 975
Glu Thr Ile Asp Pro Pro His Ile Thr Trp Lys His Gln Arg Phe Trp
980 985 990
Thr Ser Ala Arg Pro Ser Ser Gly Ala Ser Leu Asp Leu Pro Gly Phe
995 1000 1005
Arg Val Asn Leu Pro Asn Asn Thr Val Ala Phe Ser Thr Ala Ala Glu
1010 1015 1020
Leu Ala Pro Ser Ala Val Ala Ile Met Glu Ala Ala Ala Met Ala Val
1025 1030 1035 1040
Thr Pro Gly Ser Ser Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro
1045 1050 1055
Pro Ser Gly Glu Ile Thr Thr Ile Val Thr Arg Ser Leu Gly Gly Leu
1060 1065 1070
Ser Leu Ser Val Tyr Lys Ile Glu Gly Thr Thr Ser Thr Leu Val Ala
1075 1080 1085
Glu Gly Phe Ala Ala Asn Pro Gly Phe Ala Ala Ala Ser Ser Phe Asp
1090 1095 1100
Gly Pro Gly Tyr Asp Gly Phe Asn Thr Asp Tyr Ser Asp Gln Pro Asp
1105 1110 1115 1120
Pro Arg Ser Asp Leu Pro Leu Asp Ile Glu Ala Val Arg Trp Asp Pro
1125 1130 1135
Ala Thr Glu Thr Val Glu Glu Arg Met Arg Ala Ile Val Ser Glu Ala
1140 1145 1150
Met Gly Tyr Asp Val Asp Asp Leu Pro Arg Glu Leu Pro Leu Ile Asp
1155 1160 1165
Leu Gly Leu Asp Ser Leu Met Gly Met Arg Ile Lys Asn Arg Ile Glu
1170 1175 1180
Asn Asp Phe Gln Ile Pro Pro Leu Gln Val Gln Ala Leu Arg Asp Ala
1185 1190 1195 1200
Ser Val Ala Asp Val Val Ile Met Val Glu Asn Met Val Ala Gly Arg
1205 1210 1215
Ser Ser Glu Thr Leu Val Asp Ala Thr Pro Gln Val Pro Ala Glu Ala
1220 1225 1230
Ala Gly Glu Ala Gln Ala Ala Glu Ser Ser Ala Ser Gly Glu Asp Val
1235 1240 1245
Gln Gly Val Gly Val Ala Pro Arg Asp Ala Ser Glu Arg Met Val Phe
1250 1255 1260
Gly Thr Trp Ala Gly Leu Thr Gly Ala Ala Ala Ala Gly Val Thr Ser
1265 1270 1275 1280
Lys Leu Pro Gln Ile Asp Val Asp Thr Ala Thr Ala Ile Ala Glu Arg
1285 1290 1295
Leu Thr Glu Arg Ser Gly Ile Glu Ile Ser Thr Glu Gln Val Leu Ala
1300 1305 1310
Ala Glu Thr Leu Glu Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu
1315 1320 1325
Thr Glu Val Gln Gly Asn Ile Arg Val Leu Arg Gly Arg Ala Glu Gly
1330 1335 1340
Ser Thr Lys Pro Ala Val Phe Met Phe His Pro Ala Gly Gly Ser Ser
1345 1350 1355 1360
Val Val Tyr Gln Pro Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val
1365 1370 1375
Tyr Gly Val Glu Arg Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala
1380 1385 1390
Tyr Val Asp Asp Ile Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu
1395 1400 1405
Gly Gly Trp Ser Phe Gly Gly Ala Val Ala Phe Glu Val Ala His Gln
1410 1415 1420
Leu Val Gly Ser Asp Val Glu Val Ala Thr Val Ala Leu Leu Asp Thr
1425 1430 1435 1440
Val Gln Pro Ser Asn Pro Ala Pro Asp Thr Ala Glu Glu Thr Arg Ala
1445 1450 1455
Arg Trp Thr Arg Tyr Ala Asp Phe Ala Lys Lys Thr Tyr Gly Leu Asp
1460 1465 1470
Phe Glu Val Pro Phe Glu Ile Leu Asp Thr Ile Gly Glu Asp Gly Met
1475 1480 1485
Leu Ser Met Met Thr Asp Phe Leu Ala Asn Thr Asp Ala Ser Glu His
1490 1495 1500
Gly Leu Ser Ala Gly Val Leu Glu His Gln Arg Ala Ser Phe Val Asp
1505 1510 1515 1520
Asn Arg Ile Leu Ala Lys Leu Asn Phe Ala Asp Trp Ala Asn Val Glu
1525 1530 1535
Ala Pro Val Ile Leu Phe Arg Ala Glu Arg Met His Asp Gly Ala Ile
1540 1545 1550
Glu Leu Glu Pro Asn Tyr Ala Lys Ile Asp Gln Asp Gly Gly Trp Ser
1555 1560 1565
Gly Ile Val Asn Asp Leu Glu Ile Val Gln Leu Asn Gly Asp His Leu
1570 1575 1580
Ala Val Val Asp Glu Pro Glu Ile Gly Thr Val Gly Ala His Leu Ser
1585 1590 1595 1600
Arg Arg Ile Asp Glu Ile Ser Arg Lys Asn
1605 1610
<210> 15
<211> 540
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(517)
<223> RXA01138
<400> 15
cttattcaag tttttggaaa gataattaac tatgacttta aaaacagtaa acggaacgca 60
gctgcgagac actgtcggat cgttcccttc aggtgtcacg gtg gtc acc act acc 115
Val Val Thr Thr Thr
1 5
gat ggg gaa gtg gac cac ggg ttg act gtg agt gcg ttc gtg tcc ttg 163
Asp Gly Glu Val Asp His Gly Leu Thr Val Ser Ala Phe Val Ser Leu
10 15 20
tcg ttg gag cct gcc atg gtg ttg gtg agt atc gat aag aaa tca agc 211
Ser Leu Glu Pro Ala Met Val Leu Val Ser Ile Asp Lys Lys Ser Ser
25 30 35
gtt gtg ccg ttt ttg gag cag ggt tca cca gtt gct gtg tct gtg tta 259
Val Val Pro Phe Leu Glu Gln Gly Ser Pro Val Ala Val Ser Val Leu
40 45 50
tcg gaa gag cag agc gat ttg gcc atc aca ttt ggc cgt cat ctg gaa 307
Ser Glu Glu Gln Ser Asp Leu Ala Ile Thr Phe Gly Arg His Leu Glu
55 60 65
aac aaa ttc gac ggc gtt tcc att aag cgt tca aca aac agg gca gcg 355
Asn Lys Phe Asp Gly Val Ser Ile Lys Arg Ser Thr Asn Arg Ala Ala
70 75 80 85
gtc ttg gaa ggt gcg tca gca tgg ttg agt ggc gct gtg gtg gat aaa 403
Val Leu Glu Gly Ala Ser Ala Trp Leu Ser Gly Ala Val Val Asp Lys
90 95 100
tac cca ggt gga gat cac ttt att atc acc att gcc gtg gaa gag tgt 451
Tyr Pro Gly Gly Asp His Phe Ile Ile Thr Ile Ala Val Glu Glu Cys
105 110 115
gct cac gac gag gag caa aag cca ctt ctt tac cac cgt ggc agg ctt 499
Ala His Asp Glu Glu Gln Lys Pro Leu Leu Tyr His Arg Gly Arg Leu
120 125 130
ttt cag tgg caa gaa gat taattctcca ccccttcatt ttc 540
Phe Gln Trp Gln Glu Asp
135
<210> 16
<211> 139
<212> PRT
<213> Corynebacterium glutamicum
<400> 16
Val Val Thr Thr Thr Asp Gly Glu Val Asp His Gly Leu Thr Val Ser
1 5 10 15
Ala Phe Val Ser Leu Ser Leu Glu Pro Ala Met Val Leu Val Ser Ile
20 25 30
Asp Lys Lys Ser Ser Val Val Pro Phe Leu Glu Gln Gly Ser Pro Val
35 40 45
Ala Val Ser Val Leu Ser Glu Glu Gln Ser Asp Leu Ala Ile Thr Phe
50 55 60
Gly Arg His Leu Glu Asn Lys Phe Asp Gly Val Ser Ile Lys Arg Ser
65 70 75 80
Thr Asn Arg Ala Ala Val Leu Glu Gly Ala Ser Ala Trp Leu Ser Gly
85 90 95
Ala Val Val Asp Lys Tyr Pro Gly Gly Asp His Phe Ile Ile Thr Ile
100 105 110
Ala Val Glu Glu Cys Ala His Asp Glu Glu Gln Lys Pro Leu Leu Tyr
115 120 125
His Arg Gly Arg Leu Phe Gln Trp Gln Glu Asp
130 135
<210> 17
<211> 756
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(733)
<223> RXA01980
<400> 17
aggatcgtac caaataaggc aataaactct ttttactttt cctcaacttc ctgaaaagtc 60
gccgccctag aattcactaa gtttccgata tctttaaccc atg cag atc att gat 115
Met Gln Ile Ile Asp
1 5
ctc tct cat gcg ttc gcg ccc gga caa ccc cac tac cct ggg gat cca 163
Leu Ser His Ala Phe Ala Pro Gly Gln Pro His Tyr Pro Gly Asp Pro
10 15 20
gat caa gaa att aag acg gtc tcc acg att gaa aac gat ggc ttt tta 211
Asp Gln Glu Ile Lys Thr Val Ser Thr Ile Glu Asn Asp Gly Phe Leu
25 30 35
atg cat caa tac aga ctt gtt ggt ccc tgg gga acg cat gta gat gca 259
Met His Gln Tyr Arg Leu Val Gly Pro Trp Gly Thr His Val Asp Ala
40 45 50
cct gca cat ttc gat cca caa ggt cgg acg ctt gat cag atc cct gtg 307
Pro Ala His Phe Asp Pro Gln Gly Arg Thr Leu Asp Gln Ile Pro Val
55 60 65
gag gaa acg cat tta ccc ctt tat tgc ctg agg ttt tct cgc ccc gat 355
Glu Glu Thr His Leu Pro Leu Tyr Cys Leu Arg Phe Ser Arg Pro Asp
70 75 80 85
cta tgt act gct gct gat ata gaa gcg ttt gaa cat aca cac ggg aaa 403
Leu Cys Thr Ala Ala Asp Ile Glu Ala Phe Glu His Thr His Gly Lys
90 95 100
atc gaa cca gga tcc ttc gtc gca ctc cac act gga tgg gaa tgg ggt 451
Ile Glu Pro Gly Ser Phe Val Ala Leu His Thr Gly Trp Glu Trp Gly
105 110 115
aaa caa ggg atc gca ccc ggc tgg tct atc gag gct tta gaa atc ctc 499
Lys Gln Gly Ile Ala Pro Gly Trp Ser Ile Glu Ala Leu Glu Ile Leu
120 125 130
cat gcc cgt gga gtc att gcc att ggc cac gat ctt ccc gat aca gat 547
His Ala Arg Gly Val Ile Ala Ile Gly His Asp Leu Pro Asp Thr Asp
135 140 145
cct tca ctg gag gca cag cgc tgg tgg ctg tgc cgt gac cat tgg cag 595
Pro Ser Leu Glu Ala Gln Arg Trp Trp Leu Cys Arg Asp His Trp Gln
150 155 160 165
att gaa aac ctc acc aat ttg gac aag gtt cct gca acg ggt gcg atg 643
Ile Glu Asn Leu Thr Asn Leu Asp Lys Val Pro Ala Thr Gly Ala Met
170 175 180
att gct tgt cct tgg cca gtt cca aaa gat ggt gct agt ttc cca gtg 691
Ile Ala Cys Pro Trp Pro Val Pro Lys Asp Gly Ala Ser Phe Pro Val
185 190 195
cgt cca att gct ctc gtc cca gag cac cta tcc cct act cgc 733
Arg Pro Ile Ala Leu Val Pro Glu His Leu Ser Pro Thr Arg
200 205 210
taaagcgaac ggcagcacct tct 756
<210> 18
<211> 211
<212> PRT
<213> Corynebacterium glutamicum
<400> 18
Met Gln Ile Ile Asp Leu Ser His Ala Phe Ala Pro Gly Gln Pro His
1 5 10 15
Tyr Pro Gly Asp Pro Asp Gln Glu Ile Lys Thr Val Ser Thr Ile Glu
20 25 30
Asn Asp Gly Phe Leu Met His Gln Tyr Arg Leu Val Gly Pro Trp Gly
35 40 45
Thr His Val Asp Ala Pro Ala His Phe Asp Pro Gln Gly Arg Thr Leu
50 55 60
Asp Gln Ile Pro Val Glu Glu Thr His Leu Pro Leu Tyr Cys Leu Arg
65 70 75 80
Phe Ser Arg Pro Asp Leu Cys Thr Ala Ala Asp Ile Glu Ala Phe Glu
85 90 95
His Thr His Gly Lys Ile Glu Pro Gly Ser Phe Val Ala Leu His Thr
100 105 110
Gly Trp Glu Trp Gly Lys Gln Gly Ile Ala Pro Gly Trp Ser Ile Glu
115 120 125
Ala Leu Glu Ile Leu His Ala Arg Gly Val Ile Ala Ile Gly His Asp
130 135 140
Leu Pro Asp Thr Asp Pro Ser Leu Glu Ala Gln Arg Trp Trp Leu Cys
145 150 155 160
Arg Asp His Trp Gln Ile Glu Asn Leu Thr Asn Leu Asp Lys Val Pro
165 170 175
Ala Thr Gly Ala Met Ile Ala Cys Pro Trp Pro Val Pro Lys Asp Gly
180 185 190
Ala Ser Phe Pro Val Arg Pro Ile Ala Leu Val Pro Glu His Leu Ser
195 200 205
Pro Thr Arg
210
<210> 19
<211> 1830
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1807)
<223> RXN01007
<400> 19
tctgaaccaa tataccgatc agtctaaaag tgtgttaagt tctggaacat aaattagctg 60
acacgtaaag taacttaaag attcactgga ggtaagccta gtg ttt aaa aag cac 115
Val Phe Lys Lys His
1 5
aga cac ggt ctc ggc tcc ccc gaa acc aaa cca cgc tca ata acc cgc 163
Arg His Gly Leu Gly Ser Pro Glu Thr Lys Pro Arg Ser Ile Thr Arg
10 15 20
cgg ttt ttc acc gcg gcc gcc gct acg ctg gca gga ttg gca gtc ctg 211
Arg Phe Phe Thr Ala Ala Ala Ala Thr Leu Ala Gly Leu Ala Val Leu
25 30 35
tcc ggc tgc aca gca caa ccc tca caa gca gaa gac aac acg ctc act 259
Ser Gly Cys Thr Ala Gln Pro Ser Gln Ala Glu Asp Asn Thr Leu Thr
40 45 50
tac tta gag cca cag ttc ttc cgc acc ctg tac cca cca tca gcg ggc 307
Tyr Leu Glu Pro Gln Phe Phe Arg Thr Leu Tyr Pro Pro Ser Ala Gly
55 60 65
ttt tac ccc aac ggc agt gtg gtg aac aac att gca gac cgc ttg ctc 355
Phe Tyr Pro Asn Gly Ser Val Val Asn Asn Ile Ala Asp Arg Leu Leu
70 75 80 85
tac cag gat cct gaa acc ttg gaa ctc aag ccg tgg atc gcc acc gaa 403
Tyr Gln Asp Pro Glu Thr Leu Glu Leu Lys Pro Trp Ile Ala Thr Glu
90 95 100
ctc cca gaa gta aac gaa gac gcc acg gaa ttt acc ttc aac atc cgc 451
Leu Pro Glu Val Asn Glu Asp Ala Thr Glu Phe Thr Phe Asn Ile Arg
105 110 115
acc gat gtc acc tac tcc gat ggc acc ccg ctg acg gct gaa aac gtg 499
Thr Asp Val Thr Tyr Ser Asp Gly Thr Pro Leu Thr Ala Glu Asn Val
120 125 130
gtg aaa aac ttc gat ctc tat ggc ctc ggc gat caa gat cga cgc ctc 547
Val Lys Asn Phe Asp Leu Tyr Gly Leu Gly Asp Gln Asp Arg Arg Leu
135 140 145
acc atc tct gag cag atc acc aac tac gac cac ggc gaa gta gta gat 595
Thr Ile Ser Glu Gln Ile Thr Asn Tyr Asp His Gly Glu Val Val Asp
150 155 160 165
gag gac acc gtc cga ttc cac ttc tct gag cct gca cct ggt ttt gct 643
Glu Asp Thr Val Arg Phe His Phe Ser Glu Pro Ala Pro Gly Phe Ala
170 175 180
cag gcc acc agc tcc ttc aac gct ggc ctt tat gcc gat tcc acc ttg 691
Gln Ala Thr Ser Ser Phe Asn Ala Gly Leu Tyr Ala Asp Ser Thr Leu
185 190 195
gag ttc gcc aat gag gat ttc gcg cca ggc aac gcc caa aac gtc atc 739
Glu Phe Ala Asn Glu Asp Phe Ala Pro Gly Asn Ala Gln Asn Val Ile
200 205 210
ggc tcc ggt cct ttc gtg atc acc gat gaa acc cta ggc acc aac ctc 787
Gly Ser Gly Pro Phe Val Ile Thr Asp Glu Thr Leu Gly Thr Asn Leu
215 220 225
acc ttg act gcg cgt gag gat tac gat tgg gca cca cca tca cgc gaa 835
Thr Leu Thr Ala Arg Glu Asp Tyr Asp Trp Ala Pro Pro Ser Arg Glu
230 235 240 245
cat caa ggt cgc gcg aag ctt gac gcc gtc aat tat gtc ctc gcg ggt 883
His Gln Gly Arg Ala Lys Leu Asp Ala Val Asn Tyr Val Leu Ala Gly
250 255 260
gaa gaa tcc gtc cgc atc gga gcc atc gtt gct ggc caa ggt gat atc 931
Glu Glu Ser Val Arg Ile Gly Ala Ile Val Ala Gly Gln Gly Asp Ile
265 270 275
gcc cgc cag atc gaa gcg cca gtg gag gca cac ctg aag gat gca ggc 979
Ala Arg Gln Ile Glu Ala Pro Val Glu Ala His Leu Lys Asp Ala Gly
280 285 290
atc ccg atc atc tcc gca gcc acc aac ggt gtg aac aac agc ttc aac 1027
Ile Pro Ile Ile Ser Ala Ala Thr Asn Gly Val Asn Asn Ser Phe Asn
295 300 305
ttc cgc ttc aaa aac gag ctg ctc tca gac atc cgt gtt cgc caa gct 1075
Phe Arg Phe Lys Asn Glu Leu Leu Ser Asp Ile Arg Val Arg Gln Ala
310 315 320 325
ctg atc cac gcg atc gac cgc gaa aag atc atg cgt gtg ctg ttt agt 1123
Leu Ile His Ala Ile Asp Arg Glu Lys Ile Met Arg Val Leu Phe Ser
330 335 340
gat tcc tat ccg ctg gca act tct gtg ctt gcg caa aat gca ctg ggc 1171
Asp Ser Tyr Pro Leu Ala Thr Ser Val Leu Ala Gln Asn Ala Leu Gly
345 350 355
tac aaa gaa caa gta gat gcc tat gtc tac gac cta gac aaa gca aca 1219
Tyr Lys Glu Gln Val Asp Ala Tyr Val Tyr Asp Leu Asp Lys Ala Thr
360 365 370
gct ctg ctt gac gaa gcc ggc tgg acc ctt gat agc gac ggc atg cgt 1267
Ala Leu Leu Asp Glu Ala Gly Trp Thr Leu Asp Ser Asp Gly Met Arg
375 380 385
cgc aag gac ggt gaa ctt cta gag ctc acc ttc aac gaa gcc ctc cca 1315
Arg Lys Asp Gly Glu Leu Leu Glu Leu Thr Phe Asn Glu Ala Leu Pro
390 395 400 405
cag cct cgt tca cgc gaa gtt gtc acc atg gtc caa gaa cag ctc ggt 1363
Gln Pro Arg Ser Arg Glu Val Val Thr Met Val Gln Glu Gln Leu Gly
410 415 420
gat ctg ggc atc aag gtc aac ctc aac cca ggt gac caa gca gcc cag 1411
Asp Leu Gly Ile Lys Val Asn Leu Asn Pro Gly Asp Gln Ala Ala Gln
425 430 435
gac gct gac tcc aag gat ctc aac aag atc cag gtt cgc cac acc atg 1459
Asp Ala Asp Ser Lys Asp Leu Asn Lys Ile Gln Val Arg His Thr Met
440 445 450
gtg ggt cgc gca gac tat gac gtg ctg aaa tcc cag ctg tac tcc acc 1507
Val Gly Arg Ala Asp Tyr Asp Val Leu Lys Ser Gln Leu Tyr Ser Thr
455 460 465
aac cgc aac gag ctg ttg aac atg acc gtg gaa ggg gag acc gcc gat 1555
Asn Arg Asn Glu Leu Leu Asn Met Thr Val Glu Gly Glu Thr Ala Asp
470 475 480 485
att ggc gat cct cat ttg gag gaa ctc ctc atg gct att gca tcc agc 1603
Ile Gly Asp Pro His Leu Glu Glu Leu Leu Met Ala Ile Ala Ser Ser
490 495 500
cca cgc gaa gag gac cgt gca gca gca tct gcc gca gca cag gat tac 1651
Pro Arg Glu Glu Asp Arg Ala Ala Ala Ser Ala Ala Ala Gln Asp Tyr
505 510 515
atc acc gag cag gca tat gtt ctt cca ctg ttt gaa gag cca gtt gtc 1699
Ile Thr Glu Gln Ala Tyr Val Leu Pro Leu Phe Glu Glu Pro Val Val
520 525 530
tac ggc gtg cag cct tac gtg aag ggc ttt agc ccc gaa gtg atc ggc 1747
Tyr Gly Val Gln Pro Tyr Val Lys Gly Phe Ser Pro Glu Val Ile Gly
535 540 545
cgc ccc agc ttc tat gag acc tac att gac cat tcc agc gac cat tcc 1795
Arg Pro Ser Phe Tyr Glu Thr Tyr Ile Asp His Ser Ser Asp His Ser
550 555 560 565
agt gag gag gac taaatgacta cctcgcagat tct 1830
Ser Glu Glu Asp
<210> 20
<211> 569
<212> PRT
<213> Corynebacterium glutamicum
<400> 20
Val Phe Lys Lys His Arg His Gly Leu Gly Ser Pro Glu Thr Lys Pro
1 5 10 15
Arg Ser Ile Thr Arg Arg Phe Phe Thr Ala Ala Ala Ala Thr Leu Ala
20 25 30
Gly Leu Ala Val Leu Ser Gly Cys Thr Ala Gln Pro Ser Gln Ala Glu
35 40 45
Asp Asn Thr Leu Thr Tyr Leu Glu Pro Gln Phe Phe Arg Thr Leu Tyr
50 55 60
Pro Pro Ser Ala Gly Phe Tyr Pro Asn Gly Ser Val Val Asn Asn Ile
65 70 75 80
Ala Asp Arg Leu Leu Tyr Gln Asp Pro Glu Thr Leu Glu Leu Lys Pro
85 90 95
Trp Ile Ala Thr Glu Leu Pro Glu Val Asn Glu Asp Ala Thr Glu Phe
100 105 110
Thr Phe Asn Ile Arg Thr Asp Val Thr Tyr Ser Asp Gly Thr Pro Leu
115 120 125
Thr Ala Glu Asn Val Val Lys Asn Phe Asp Leu Tyr Gly Leu Gly Asp
130 135 140
Gln Asp Arg Arg Leu Thr Ile Ser Glu Gln Ile Thr Asn Tyr Asp His
145 150 155 160
Gly Glu Val Val Asp Glu Asp Thr Val Arg Phe His Phe Ser Glu Pro
165 170 175
Ala Pro Gly Phe Ala Gln Ala Thr Ser Ser Phe Asn Ala Gly Leu Tyr
180 185 190
Ala Asp Ser Thr Leu Glu Phe Ala Asn Glu Asp Phe Ala Pro Gly Asn
195 200 205
Ala Gln Asn Val Ile Gly Ser Gly Pro Phe Val Ile Thr Asp Glu Thr
210 215 220
Leu Gly Thr Asn Leu Thr Leu Thr Ala Arg Glu Asp Tyr Asp Trp Ala
225 230 235 240
Pro Pro Ser Arg Glu His Gln Gly Arg Ala Lys Leu Asp Ala Val Asn
245 250 255
Tyr Val Leu Ala Gly Glu Glu Ser Val Arg Ile Gly Ala Ile Val Ala
260 265 270
Gly Gln Gly Asp Ile Ala Arg Gln Ile Glu Ala Pro Val Glu Ala His
275 280 285
Leu Lys Asp Ala Gly Ile Pro Ile Ile Ser Ala Ala Thr Asn Gly Val
290 295 300
Asn Asn Ser Phe Asn Phe Arg Phe Lys Asn Glu Leu Leu Ser Asp Ile
305 310 315 320
Arg Val Arg Gln Ala Leu Ile His Ala Ile Asp Arg Glu Lys Ile Met
325 330 335
Arg Val Leu Phe Ser Asp Ser Tyr Pro Leu Ala Thr Ser Val Leu Ala
340 345 350
Gln Asn Ala Leu Gly Tyr Lys Glu Gln Val Asp Ala Tyr Val Tyr Asp
355 360 365
Leu Asp Lys Ala Thr Ala Leu Leu Asp Glu Ala Gly Trp Thr Leu Asp
370 375 380
Ser Asp Gly Met Arg Arg Lys Asp Gly Glu Leu Leu Glu Leu Thr Phe
385 390 395 400
Asn Glu Ala Leu Pro Gln Pro Arg Ser Arg Glu Val Val Thr Met Val
405 410 415
Gln Glu Gln Leu Gly Asp Leu Gly Ile Lys Val Asn Leu Asn Pro Gly
420 425 430
Asp Gln Ala Ala Gln Asp Ala Asp Ser Lys Asp Leu Asn Lys Ile Gln
435 440 445
Val Arg His Thr Met Val Gly Arg Ala Asp Tyr Asp Val Leu Lys Ser
450 455 460
Gln Leu Tyr Ser Thr Asn Arg Asn Glu Leu Leu Asn Met Thr Val Glu
465 470 475 480
Gly Glu Thr Ala Asp Ile Gly Asp Pro His Leu Glu Glu Leu Leu Met
485 490 495
Ala Ile Ala Ser Ser Pro Arg Glu Glu Asp Arg Ala Ala Ala Ser Ala
500 505 510
Ala Ala Gln Asp Tyr Ile Thr Glu Gln Ala Tyr Val Leu Pro Leu Phe
515 520 525
Glu Glu Pro Val Val Tyr Gly Val Gln Pro Tyr Val Lys Gly Phe Ser
530 535 540
Pro Glu Val Ile Gly Arg Pro Ser Phe Tyr Glu Thr Tyr Ile Asp His
545 550 555 560
Ser Ser Asp His Ser Ser Glu Glu Asp
565
<210> 21
<211> 858
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(835)
<223> RXN00784
<400> 21
gtcacatcag ttatcgcgcg gaatagttag cgggcgcatg tggttgggat atatgaataa 60
atctattcca actacgcgta aaacgaggac gtttaaagct atg tct att gaa ttc 115
Met Ser Ile Glu Phe
1 5
tcc gca cca gca aaa atg aaa atc gaa gtg tgg agc gac atc atg tgc 163
Ser Ala Pro Ala Lys Met Lys Ile Glu Val Trp Ser Asp Ile Met Cys
10 15 20
ccc ttc tgc tac atc ggc aaa aag cgc ctc gac gac gcc cta agt acc 211
Pro Phe Cys Tyr Ile Gly Lys Lys Arg Leu Asp Asp Ala Leu Ser Thr
25 30 35
ttt gac cag gcc gga cgc atc gaa gtg gaa tac aag agc ttc gaa ctc 259
Phe Asp Gln Ala Gly Arg Ile Glu Val Glu Tyr Lys Ser Phe Glu Leu
40 45 50
atg cca ggc cta gaa acc cac cca ctg cgt tcc gac gtt gaa tac ctc 307
Met Pro Gly Leu Glu Thr His Pro Leu Arg Ser Asp Val Glu Tyr Leu
55 60 65
gcc gac gcc aag ggc atg agc ctc gag cag gcc cgc caa atg aac ggc 355
Ala Asp Ala Lys Gly Met Ser Leu Glu Gln Ala Arg Gln Met Asn Gly
70 75 80 85
caa gtc caa gca atg gca caa gcc acc gga ctt gaa atg aat cct gac 403
Gln Val Gln Ala Met Ala Gln Ala Thr Gly Leu Glu Met Asn Pro Asp
90 95 100
gaa acc atc gcg gcc aac acc atc aac gcg cac cgc ctt acc cac ttc 451
Glu Thr Ile Ala Ala Asn Thr Ile Asn Ala His Arg Leu Thr His Phe
105 110 115
gcg aaa gcc cac ggc aag caa caa gaa gtg gcg cag gaa ctc ttc aag 499
Ala Lys Ala His Gly Lys Gln Gln Glu Val Ala Gln Glu Leu Phe Lys
120 125 130
gct cac ttc gta gac ggc aag aac gtt gat gac ctc gat gtg ctg gtc 547
Ala His Phe Val Asp Gly Lys Asn Val Asp Asp Leu Asp Val Leu Val
135 140 145
tcc att gct gca gag gtt ggt ctc gat gcc agt gca gcc cgc gaa gct 595
Ser Ile Ala Ala Glu Val Gly Leu Asp Ala Ser Ala Ala Arg Glu Ala
150 155 160 165
ctc gaa tcc gac gtg tac acc aac gaa gtc caa caa gac gtc cac gaa 643
Leu Glu Ser Asp Val Tyr Thr Asn Glu Val Gln Gln Asp Val His Glu
170 175 180
gcc cgc caa ctc ggc gtc caa ggt gtg ccc ttc ttt gta ttc gac cgc 691
Ala Arg Gln Leu Gly Val Gln Gly Val Pro Phe Phe Val Phe Asp Arg
185 190 195
aaa tac gcc atc aac ggc gcc caa caa gaa gaa gta ttc acc ggc acc 739
Lys Tyr Ala Ile Asn Gly Ala Gln Gln Glu Glu Val Phe Thr Gly Thr
200 205 210
gta gaa aaa gcc ttc gaa gag tgg gca gcc gaa aac cca gtc agc cca 787
Val Glu Lys Ala Phe Glu Glu Trp Ala Ala Glu Asn Pro Val Ser Pro
215 220 225
ttt gag gtc att gac ggc caa agc tgc tcc gtc gac ggc acc tgc aac 835
Phe Glu Val Ile Asp Gly Gln Ser Cys Ser Val Asp Gly Thr Cys Asn
230 235 240 245
taacttttgg gacctatgtg cgt 858
<210> 22
<211> 245
<212> PRT
<213> Corynebacterium glutamicum
<400> 22
Met Ser Ile Glu Phe Ser Ala Pro Ala Lys Met Lys Ile Glu Val Trp
1 5 10 15
Ser Asp Ile Met Cys Pro Phe Cys Tyr Ile Gly Lys Lys Arg Leu Asp
20 25 30
Asp Ala Leu Ser Thr Phe Asp Gln Ala Gly Arg Ile Glu Val Glu Tyr
35 40 45
Lys Ser Phe Glu Leu Met Pro Gly Leu Glu Thr His Pro Leu Arg Ser
50 55 60
Asp Val Glu Tyr Leu Ala Asp Ala Lys Gly Met Ser Leu Glu Gln Ala
65 70 75 80
Arg Gln Met Asn Gly Gln Val Gln Ala Met Ala Gln Ala Thr Gly Leu
85 90 95
Glu Met Asn Pro Asp Glu Thr Ile Ala Ala Asn Thr Ile Asn Ala His
100 105 110
Arg Leu Thr His Phe Ala Lys Ala His Gly Lys Gln Gln Glu Val Ala
115 120 125
Gln Glu Leu Phe Lys Ala His Phe Val Asp Gly Lys Asn Val Asp Asp
130 135 140
Leu Asp Val Leu Val Ser Ile Ala Ala Glu Val Gly Leu Asp Ala Ser
145 150 155 160
Ala Ala Arg Glu Ala Leu Glu Ser Asp Val Tyr Thr Asn Glu Val Gln
165 170 175
Gln Asp Val His Glu Ala Arg Gln Leu Gly Val Gln Gly Val Pro Phe
180 185 190
Phe Val Phe Asp Arg Lys Tyr Ala Ile Asn Gly Ala Gln Gln Glu Glu
195 200 205
Val Phe Thr Gly Thr Val Glu Lys Ala Phe Glu Glu Trp Ala Ala Glu
210 215 220
Asn Pro Val Ser Pro Phe Glu Val Ile Asp Gly Gln Ser Cys Ser Val
225 230 235 240
Asp Gly Thr Cys Asn
245
<210> 23
<211> 1896
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1873)
<223> RXA02335
<400> 23
tggttgagtt cttcggggtt gagtgtgcaa gaatattcac tattggtcag gcaactatgt 60
gtctacccac tgagtcatca atttaaatca ggagttatta gtg tca gtc gag act 115
Val Ser Val Glu Thr
1 5
agg aag atc acc aag gtt ctt gtc gct aac cgt ggt gag att gca atc 163
Arg Lys Ile Thr Lys Val Leu Val Ala Asn Arg Gly Glu Ile Ala Ile
10 15 20
cgc gtg ttc cgt gca gct cga gat gaa ggc atg gga tct gtc gcc gtc 211
Arg Val Phe Arg Ala Ala Arg Asp Glu Gly Met Gly Ser Val Ala Val
25 30 35
tac gca gag cca gat gca gat gca cca ttc gtg tca tat gca gac gag 259
Tyr Ala Glu Pro Asp Ala Asp Ala Pro Phe Val Ser Tyr Ala Asp Glu
40 45 50
gct ttt gcc ctc ggt ggc caa aca tcc gct gag tcc tac ctt gtc att 307
Ala Phe Ala Leu Gly Gly Gln Thr Ser Ala Glu Ser Tyr Leu Val Ile
55 60 65
gac aag atc atc gat gcg gcc cgc aag tcc ggc gcc gac gcc atc cac 355
Asp Lys Ile Ile Asp Ala Ala Arg Lys Ser Gly Ala Asp Ala Ile His
70 75 80 85
ccc ggc tac ggc ttc ctc gca gaa aac gct gac ttc gca gaa gca gtc 403
Pro Gly Tyr Gly Phe Leu Ala Glu Asn Ala Asp Phe Ala Glu Ala Val
90 95 100
atc aac gaa ggc ctg atc tgg att gga cct tca cct gag tcc atc cgc 451
Ile Asn Glu Gly Leu Ile Trp Ile Gly Pro Ser Pro Glu Ser Ile Arg
105 110 115
tcc ctc ggc gac aag gtc acc gct cgc cac atc gca gat acc gcc aag 499
Ser Leu Gly Asp Lys Val Thr Ala Arg His Ile Ala Asp Thr Ala Lys
120 125 130
gct cca atg gct cct ggc acc aag gaa cca gta aaa gac gca gca gaa 547
Ala Pro Met Ala Pro Gly Thr Lys Glu Pro Val Lys Asp Ala Ala Glu
135 140 145
gtt gtg gct ttc gct gaa gaa ttc ggt ctc cca atc gcc atc aag gca 595
Val Val Ala Phe Ala Glu Glu Phe Gly Leu Pro Ile Ala Ile Lys Ala
150 155 160 165
gct ttc ggt ggc ggc gga cgt ggc atg aag gtt gcc tac aag atg gaa 643
Ala Phe Gly Gly Gly Gly Arg Gly Met Lys Val Ala Tyr Lys Met Glu
170 175 180
gaa gtc gct gac ctc ttc gag tcc gca acc cgt gaa gca acc gca gcg 691
Glu Val Ala Asp Leu Phe Glu Ser Ala Thr Arg Glu Ala Thr Ala Ala
185 190 195
ttc ggc cgc ggc gag tgc ttc gtg gag cgc tac ctg gac aag gca cgc 739
Phe Gly Arg Gly Glu Cys Phe Val Glu Arg Tyr Leu Asp Lys Ala Arg
200 205 210
cac gtt gag gct cag gtc atc gcc gat aag cac ggc aac gtt gtt gtc 787
His Val Glu Ala Gln Val Ile Ala Asp Lys His Gly Asn Val Val Val
215 220 225
gcc gga acc cgt gac tgc tcc ctg cag cgc cgt ttc cag aag ctc gtc 835
Ala Gly Thr Arg Asp Cys Ser Leu Gln Arg Arg Phe Gln Lys Leu Val
230 235 240 245
gaa gaa gca cca gca cca ttc ctc acc gat gac cag cgc gag cgt ctc 883
Glu Glu Ala Pro Ala Pro Phe Leu Thr Asp Asp Gln Arg Glu Arg Leu
250 255 260
cac tcc tcc gcg aag gct atc tgt aag gaa gct ggc tac tac ggt gca 931
His Ser Ser Ala Lys Ala Ile Cys Lys Glu Ala Gly Tyr Tyr Gly Ala
265 270 275
ggc acc gtt gag tac ctc gtt ggc tcc gac ggc ctg atc tcc ttc ctc 979
Gly Thr Val Glu Tyr Leu Val Gly Ser Asp Gly Leu Ile Ser Phe Leu
280 285 290
gag gtc aac acc cgc ctc cag gtg gaa cac cca gtc acc gaa gag acc 1027
Glu Val Asn Thr Arg Leu Gln Val Glu His Pro Val Thr Glu Glu Thr
295 300 305
acc ggc atc gac ctg gtc cgc gaa atg ttc cgc atc gca gaa ggc cac 1075
Thr Gly Ile Asp Leu Val Arg Glu Met Phe Arg Ile Ala Glu Gly His
310 315 320 325
gag ctc tcc atc aag gaa gat cca gct cca cgc ggc cac gca ttc gag 1123
Glu Leu Ser Ile Lys Glu Asp Pro Ala Pro Arg Gly His Ala Phe Glu
330 335 340
ttc cgc atc aac ggc gaa gac gct ggc tcc aac ttc atg cct gca cca 1171
Phe Arg Ile Asn Gly Glu Asp Ala Gly Ser Asn Phe Met Pro Ala Pro
345 350 355
ggc aag atc acc agc tac cgc gag cca cag ggc cca ggc gtc cgc atg 1219
Gly Lys Ile Thr Ser Tyr Arg Glu Pro Gln Gly Pro Gly Val Arg Met
360 365 370
gac tcc ggt gtc gtt gaa ggt tcc gaa atc tcc gga cag ttc gac tcc 1267
Asp Ser Gly Val Val Glu Gly Ser Glu Ile Ser Gly Gln Phe Asp Ser
375 380 385
atg ctg gca aag ctg atc gtt tgg ggc gac acc cgc gag cag gct ctc 1315
Met Leu Ala Lys Leu Ile Val Trp Gly Asp Thr Arg Glu Gln Ala Leu
390 395 400 405
cag cgc tcc cgc cgt gca ctt gca gag tac gtt gtc gag ggc atg cca 1363
Gln Arg Ser Arg Arg Ala Leu Ala Glu Tyr Val Val Glu Gly Met Pro
410 415 420
acc gtt atc cca ttc cac cag cac atc gtg gaa aac cca gca ttc gtg 1411
Thr Val Ile Pro Phe His Gln His Ile Val Glu Asn Pro Ala Phe Val
425 430 435
ggc aac gac gaa ggc ttc gag atc tac acc aag tgg atc gaa gag gtt 1459
Gly Asn Asp Glu Gly Phe Glu Ile Tyr Thr Lys Trp Ile Glu Glu Val
440 445 450
tgg gat aac cca atc gca cct tac gtt gac gct tcc gag ctc gac gaa 1507
Trp Asp Asn Pro Ile Ala Pro Tyr Val Asp Ala Ser Glu Leu Asp Glu
455 460 465
gat gag gac aag acc cca gca cag aag gtt gtt gtg gag atc aac ggc 1555
Asp Glu Asp Lys Thr Pro Ala Gln Lys Val Val Val Glu Ile Asn Gly
470 475 480 485
cgt cgc gtt gag gtt gca ctc cca ggc gat ctg gca ctc ggt ggc acc 1603
Arg Arg Val Glu Val Ala Leu Pro Gly Asp Leu Ala Leu Gly Gly Thr
490 495 500
gct ggt cct aag aag aag gcc aag aag cgt cgc gca ggt ggt gca aag 1651
Ala Gly Pro Lys Lys Lys Ala Lys Lys Arg Arg Ala Gly Gly Ala Lys
505 510 515
gct ggc gta tcc ggc gat gca gtg gca gct cca atg cag ggc act gtc 1699
Ala Gly Val Ser Gly Asp Ala Val Ala Ala Pro Met Gln Gly Thr Val
520 525 530
atc aag gtc aac gtc gaa gaa ggc gct gaa gtc aac gaa ggc gac acc 1747
Ile Lys Val Asn Val Glu Glu Gly Ala Glu Val Asn Glu Gly Asp Thr
535 540 545
gtt gtt gtc ctc gag gct atg aag atg gaa aac cct gtg aag gct cat 1795
Val Val Val Leu Glu Ala Met Lys Met Glu Asn Pro Val Lys Ala His
550 555 560 565
aag tcc gga acc gta acc ggc ctt act gtc gct gca ggc gag ggt gtc 1843
Lys Ser Gly Thr Val Thr Gly Leu Thr Val Ala Ala Gly Glu Gly Val
570 575 580
aac aag ggc gtt gtt ctc ctc gag atc aag taagttcttg gattcctgtt 1893
Asn Lys Gly Val Val Leu Leu Glu Ile Lys
585 590
agt 1896
<210> 24
<211> 591
<212> PRT
<213> Corynebacterium glutamicum
<400> 24
Val Ser Val Glu Thr Arg Lys Ile Thr Lys Val Leu Val Ala Asn Arg
1 5 10 15
Gly Glu Ile Ala Ile Arg Val Phe Arg Ala Ala Arg Asp Glu Gly Met
20 25 30
Gly Ser Val Ala Val Tyr Ala Glu Pro Asp Ala Asp Ala Pro Phe Val
35 40 45
Ser Tyr Ala Asp Glu Ala Phe Ala Leu Gly Gly Gln Thr Ser Ala Glu
50 55 60
Ser Tyr Leu Val Ile Asp Lys Ile Ile Asp Ala Ala Arg Lys Ser Gly
65 70 75 80
Ala Asp Ala Ile His Pro Gly Tyr Gly Phe Leu Ala Glu Asn Ala Asp
85 90 95
Phe Ala Glu Ala Val Ile Asn Glu Gly Leu Ile Trp Ile Gly Pro Ser
100 105 110
Pro Glu Ser Ile Arg Ser Leu Gly Asp Lys Val Thr Ala Arg His Ile
115 120 125
Ala Asp Thr Ala Lys Ala Pro Met Ala Pro Gly Thr Lys Glu Pro Val
130 135 140
Lys Asp Ala Ala Glu Val Val Ala Phe Ala Glu Glu Phe Gly Leu Pro
145 150 155 160
Ile Ala Ile Lys Ala Ala Phe Gly Gly Gly Gly Arg Gly Met Lys Val
165 170 175
Ala Tyr Lys Met Glu Glu Val Ala Asp Leu Phe Glu Ser Ala Thr Arg
180 185 190
Glu Ala Thr Ala Ala Phe Gly Arg Gly Glu Cys Phe Val Glu Arg Tyr
195 200 205
Leu Asp Lys Ala Arg His Val Glu Ala Gln Val Ile Ala Asp Lys His
210 215 220
Gly Asn Val Val Val Ala Gly Thr Arg Asp Cys Ser Leu Gln Arg Arg
225 230 235 240
Phe Gln Lys Leu Val Glu Glu Ala Pro Ala Pro Phe Leu Thr Asp Asp
245 250 255
Gln Arg Glu Arg Leu His Ser Ser Ala Lys Ala Ile Cys Lys Glu Ala
260 265 270
Gly Tyr Tyr Gly Ala Gly Thr Val Glu Tyr Leu Val Gly Ser Asp Gly
275 280 285
Leu Ile Ser Phe Leu Glu Val Asn Thr Arg Leu Gln Val Glu His Pro
290 295 300
Val Thr Glu Glu Thr Thr Gly Ile Asp Leu Val Arg Glu Met Phe Arg
305 310 315 320
Ile Ala Glu Gly His Glu Leu Ser Ile Lys Glu Asp Pro Ala Pro Arg
325 330 335
Gly His Ala Phe Glu Phe Arg Ile Asn Gly Glu Asp Ala Gly Ser Asn
340 345 350
Phe Met Pro Ala Pro Gly Lys Ile Thr Ser Tyr Arg Glu Pro Gln Gly
355 360 365
Pro Gly Val Arg Met Asp Ser Gly Val Val Glu Gly Ser Glu Ile Ser
370 375 380
Gly Gln Phe Asp Ser Met Leu Ala Lys Leu Ile Val Trp Gly Asp Thr
385 390 395 400
Arg Glu Gln Ala Leu Gln Arg Ser Arg Arg Ala Leu Ala Glu Tyr Val
405 410 415
Val Glu Gly Met Pro Thr Val Ile Pro Phe His Gln His Ile Val Glu
420 425 430
Asn Pro Ala Phe Val Gly Asn Asp Glu Gly Phe Glu Ile Tyr Thr Lys
435 440 445
Trp Ile Glu Glu Val Trp Asp Asn Pro Ile Ala Pro Tyr Val Asp Ala
450 455 460
Ser Glu Leu Asp Glu Asp Glu Asp Lys Thr Pro Ala Gln Lys Val Val
465 470 475 480
Val Glu Ile Asn Gly Arg Arg Val Glu Val Ala Leu Pro Gly Asp Leu
485 490 495
Ala Leu Gly Gly Thr Ala Gly Pro Lys Lys Lys Ala Lys Lys Arg Arg
500 505 510
Ala Gly Gly Ala Lys Ala Gly Val Ser Gly Asp Ala Val Ala Ala Pro
515 520 525
Met Gln Gly Thr Val Ile Lys Val Asn Val Glu Glu Gly Ala Glu Val
530 535 540
Asn Glu Gly Asp Thr Val Val Val Leu Glu Ala Met Lys Met Glu Asn
545 550 555 560
Pro Val Lys Ala His Lys Ser Gly Thr Val Thr Gly Leu Thr Val Ala
565 570 575
Ala Gly Glu Gly Val Asn Lys Gly Val Val Leu Leu Glu Ile Lys
580 585 590
<210> 25
<211> 1575
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1552)
<223> RXA02173
<400> 25
ctaaattggg cttagatctt ccgcctctaa ataggtatgc agagacattc gaattaatta 60
acaaagccat ttttcggccg tggagaagcg ttttccgact atg gtg tgg ggc atg 115
Met Val Trp Gly Met
1 5
gaa cac act tca gca ttg acg ctc ata gac tcg gtt ttg gac cct gac 163
Glu His Thr Ser Ala Leu Thr Leu Ile Asp Ser Val Leu Asp Pro Asp
10 15 20
agc ttc att tct tgg aat gaa act ccc caa tat gac aac ctc aat caa 211
Ser Phe Ile Ser Trp Asn Glu Thr Pro Gln Tyr Asp Asn Leu Asn Gln
25 30 35
ggc tat gca gag acc ttg gag cgg gct cga agc aag gcc aaa tgc gat 259
Gly Tyr Ala Glu Thr Leu Glu Arg Ala Arg Ser Lys Ala Lys Cys Asp
40 45 50
gaa tcg gta att act gga gaa ggc acc gtg gag ggc att ccg gta gcc 307
Glu Ser Val Ile Thr Gly Glu Gly Thr Val Glu Gly Ile Pro Val Ala
55 60 65
gtt att ttg tcc gat ttt tcc ttc ctc ggc ggt tct ttg ggc acg gtc 355
Val Ile Leu Ser Asp Phe Ser Phe Leu Gly Gly Ser Leu Gly Thr Val
70 75 80 85
gcg tcg gtg cgc atc atg aag gcg att cac cgc gcc aca gag ctg aaa 403
Ala Ser Val Arg Ile Met Lys Ala Ile His Arg Ala Thr Glu Leu Lys
90 95 100
ctc cca ctg ctg gtc tcc cct gct tcc ggt ggt gcg cgc atg cag gaa 451
Leu Pro Leu Leu Val Ser Pro Ala Ser Gly Gly Ala Arg Met Gln Glu
105 110 115
gac aat cga gct ttt gtc atg atg gtg tcc ata acc gcg gct gtg cag 499
Asp Asn Arg Ala Phe Val Met Met Val Ser Ile Thr Ala Ala Val Gln
120 125 130
cgt cac cgc gag gcg cat ttg ccg ttc ctg gtg tat ttg cgc aat ccc 547
Arg His Arg Glu Ala His Leu Pro Phe Leu Val Tyr Leu Arg Asn Pro
135 140 145
acg atg ggt ggc gcc atg gcc tcg tgg ggt tca tct ggg cat ctc act 595
Thr Met Gly Gly Ala Met Ala Ser Trp Gly Ser Ser Gly His Leu Thr
150 155 160 165
ttt gcg gaa ccc ggc gcg cag ata ggt ttc ctg ggt cct cgc gtg gtg 643
Phe Ala Glu Pro Gly Ala Gln Ile Gly Phe Leu Gly Pro Arg Val Val
170 175 180
gag tta acc act ggg cat gcg ctt cca gac ggt gtg cag cag gcg gag 691
Glu Leu Thr Thr Gly His Ala Leu Pro Asp Gly Val Gln Gln Ala Glu
185 190 195
aat ttg gtg aaa act ggt gtg att gat gga att gtg tcg cca ctc caa 739
Asn Leu Val Lys Thr Gly Val Ile Asp Gly Ile Val Ser Pro Leu Gln
200 205 210
ttg cgt gca gcg gtg gca aaa acc ctc aag gtt att cag ccg gta gag 787
Leu Arg Ala Ala Val Ala Lys Thr Leu Lys Val Ile Gln Pro Val Glu
215 220 225
gca acg gat cgt ttt tct cca aca act cct ggc gtg gca ctt ccg gtg 835
Ala Thr Asp Arg Phe Ser Pro Thr Thr Pro Gly Val Ala Leu Pro Val
230 235 240 245
atg gag gcg att gcg cgt tct cgt gac ccg cag agg cct gga atc ggg 883
Met Glu Ala Ile Ala Arg Ser Arg Asp Pro Gln Arg Pro Gly Ile Gly
250 255 260
gag att atg gaa acg ttg ggg gca gac gtc gtc aag ctt tct ggt gcg 931
Glu Ile Met Glu Thr Leu Gly Ala Asp Val Val Lys Leu Ser Gly Ala
265 270 275
cgt gct ggc gca ttg agc ccg gct gtg cgc gtt gcc ctg gcg cgc atc 979
Arg Ala Gly Ala Leu Ser Pro Ala Val Arg Val Ala Leu Ala Arg Ile
280 285 290
ggg ggc cgg ccc gtg gtg ctg att ggg cag gat cgc cgc ttc acg ctt 1027
Gly Gly Arg Pro Val Val Leu Ile Gly Gln Asp Arg Arg Phe Thr Leu
295 300 305
ggg ccg cag gag ctg cgt ttt gcg cgt cgt ggc att tcg ctg gcg cgc 1075
Gly Pro Gln Glu Leu Arg Phe Ala Arg Arg Gly Ile Ser Leu Ala Arg
310 315 320 325
gag cta aac ctg ccg atc gtg tcc atc atc gac acc tcc ggc gcc gaa 1123
Glu Leu Asn Leu Pro Ile Val Ser Ile Ile Asp Thr Ser Gly Ala Glu
330 335 340
ttg tcg cag gcg gct gag gag ctc ggc atc gca agc tcg att gcg cgc 1171
Leu Ser Gln Ala Ala Glu Glu Leu Gly Ile Ala Ser Ser Ile Ala Arg
345 350 355
acc ttg tcc aag ctt atc gac gct ccc ctc ccc acc gtt tcg gtc att 1219
Thr Leu Ser Lys Leu Ile Asp Ala Pro Leu Pro Thr Val Ser Val Ile
360 365 370
att ggt cag ggc gtt ggc ggt ggc gcg ctg gcc atg ctg ccc gcc gat 1267
Ile Gly Gln Gly Val Gly Gly Gly Ala Leu Ala Met Leu Pro Ala Asp
375 380 385
ctg gtc tac gcg gcc gaa aac gcg tgg ctg tcc gca ttg cca cca gag 1315
Leu Val Tyr Ala Ala Glu Asn Ala Trp Leu Ser Ala Leu Pro Pro Glu
390 395 400 405
ggc gcc tcg gcc atc ctc ttc cgc gac acc aac cac gcc gcg gaa atc 1363
Gly Ala Ser Ala Ile Leu Phe Arg Asp Thr Asn His Ala Ala Glu Ile
410 415 420
ata gag cga caa ggc gtg cag gcg cac gca ctt tta agc caa ggg ctt 1411
Ile Glu Arg Gln Gly Val Gln Ala His Ala Leu Leu Ser Gln Gly Leu
425 430 435
atc gac ggg atc gtc gcc gaa acc gag cac ttt gtt gaa gaa att ctc 1459
Ile Asp Gly Ile Val Ala Glu Thr Glu His Phe Val Glu Glu Ile Leu
440 445 450
ggc aca atc agc aac gcc ctc tcc gaa ttg gat aac aat ccg gag agg 1507
Gly Thr Ile Ser Asn Ala Leu Ser Glu Leu Asp Asn Asn Pro Glu Arg
455 460 465
gcg gga cgc gac agt cgc ttc aca cga ttt gag cgt tta gcg cag 1552
Ala Gly Arg Asp Ser Arg Phe Thr Arg Phe Glu Arg Leu Ala Gln
470 475 480
taaagaaaat tatgcgctga tca 1575
<210> 26
<211> 484
<212> PRT
<213> Corynebacterium glutamicum
<400> 26
Met Val Trp Gly Met Glu His Thr Ser Ala Leu Thr Leu Ile Asp Ser
1 5 10 15
Val Leu Asp Pro Asp Ser Phe Ile Ser Trp Asn Glu Thr Pro Gln Tyr
20 25 30
Asp Asn Leu Asn Gln Gly Tyr Ala Glu Thr Leu Glu Arg Ala Arg Ser
35 40 45
Lys Ala Lys Cys Asp Glu Ser Val Ile Thr Gly Glu Gly Thr Val Glu
50 55 60
Gly Ile Pro Val Ala Val Ile Leu Ser Asp Phe Ser Phe Leu Gly Gly
65 70 75 80
Ser Leu Gly Thr Val Ala Ser Val Arg Ile Met Lys Ala Ile His Arg
85 90 95
Ala Thr Glu Leu Lys Leu Pro Leu Leu Val Ser Pro Ala Ser Gly Gly
100 105 110
Ala Arg Met Gln Glu Asp Asn Arg Ala Phe Val Met Met Val Ser Ile
115 120 125
Thr Ala Ala Val Gln Arg His Arg Glu Ala His Leu Pro Phe Leu Val
130 135 140
Tyr Leu Arg Asn Pro Thr Met Gly Gly Ala Met Ala Ser Trp Gly Ser
145 150 155 160
Ser Gly His Leu Thr Phe Ala Glu Pro Gly Ala Gln Ile Gly Phe Leu
165 170 175
Gly Pro Arg Val Val Glu Leu Thr Thr Gly His Ala Leu Pro Asp Gly
180 185 190
Val Gln Gln Ala Glu Asn Leu Val Lys Thr Gly Val Ile Asp Gly Ile
195 200 205
Val Ser Pro Leu Gln Leu Arg Ala Ala Val Ala Lys Thr Leu Lys Val
210 215 220
Ile Gln Pro Val Glu Ala Thr Asp Arg Phe Ser Pro Thr Thr Pro Gly
225 230 235 240
Val Ala Leu Pro Val Met Glu Ala Ile Ala Arg Ser Arg Asp Pro Gln
245 250 255
Arg Pro Gly Ile Gly Glu Ile Met Glu Thr Leu Gly Ala Asp Val Val
260 265 270
Lys Leu Ser Gly Ala Arg Ala Gly Ala Leu Ser Pro Ala Val Arg Val
275 280 285
Ala Leu Ala Arg Ile Gly Gly Arg Pro Val Val Leu Ile Gly Gln Asp
290 295 300
Arg Arg Phe Thr Leu Gly Pro Gln Glu Leu Arg Phe Ala Arg Arg Gly
305 310 315 320
Ile Ser Leu Ala Arg Glu Leu Asn Leu Pro Ile Val Ser Ile Ile Asp
325 330 335
Thr Ser Gly Ala Glu Leu Ser Gln Ala Ala Glu Glu Leu Gly Ile Ala
340 345 350
Ser Ser Ile Ala Arg Thr Leu Ser Lys Leu Ile Asp Ala Pro Leu Pro
355 360 365
Thr Val Ser Val Ile Ile Gly Gln Gly Val Gly Gly Gly Ala Leu Ala
370 375 380
Met Leu Pro Ala Asp Leu Val Tyr Ala Ala Glu Asn Ala Trp Leu Ser
385 390 395 400
Ala Leu Pro Pro Glu Gly Ala Ser Ala Ile Leu Phe Arg Asp Thr Asn
405 410 415
His Ala Ala Glu Ile Ile Glu Arg Gln Gly Val Gln Ala His Ala Leu
420 425 430
Leu Ser Gln Gly Leu Ile Asp Gly Ile Val Ala Glu Thr Glu His Phe
435 440 445
Val Glu Glu Ile Leu Gly Thr Ile Ser Asn Ala Leu Ser Glu Leu Asp
450 455 460
Asn Asn Pro Glu Arg Ala Gly Arg Asp Ser Arg Phe Thr Arg Phe Glu
465 470 475 480
Arg Leu Ala Gln
<210> 27
<211> 1056
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1033)
<223> RXA01764
<400> 27
ttttcaaaat taatagttga cattttcaac gttatgagtt ttcattggta tcacgccccg 60
acgaagtgtc tgggatcaca aaccttcaaa ggagtttgaa atg tct ctc aat gga 115
Met Ser Leu Asn Gly
1 5
aaa gtc gcc atc gtt acc gga tct ggt gca gga ctt ggt cgt tcc ttc 163
Lys Val Ala Ile Val Thr Gly Ser Gly Ala Gly Leu Gly Arg Ser Phe
10 15 20
gct cag gag ctt gcc cgt cag ggt gca tct gtc atc gtc aat gac gta 211
Ala Gln Glu Leu Ala Arg Gln Gly Ala Ser Val Ile Val Asn Asp Val
25 30 35
aac cag gca gcc gca gat gag act gtc gca gca atc acc gaa gcc ggc 259
Asn Gln Ala Ala Ala Asp Glu Thr Val Ala Ala Ile Thr Glu Ala Gly
40 45 50
ggc aaa gcc gcc gcc gtt atc gcc ccc gtt gga ccc tct gaa agc gcc 307
Gly Lys Ala Ala Ala Val Ile Ala Pro Val Gly Pro Ser Glu Ser Ala
55 60 65
gca ttg ctg gtg cgg gag gcc gtc gac aag ttc ggt tct ttg gac att 355
Ala Leu Leu Val Arg Glu Ala Val Asp Lys Phe Gly Ser Leu Asp Ile
70 75 80 85
ctt gtc aca aac gcg ggc atc ctt cgt gat agg tcc ctg ctg aag atg 403
Leu Val Thr Asn Ala Gly Ile Leu Arg Asp Arg Ser Leu Leu Lys Met
90 95 100
acg gac gat gat ttc gat gca gtc att aac gtg cac ctc aag ggc act 451
Thr Asp Asp Asp Phe Asp Ala Val Ile Asn Val His Leu Lys Gly Thr
105 110 115
ttc acc tgt gtt cgc gag gca ttt gga tac ttc aag gag aat gga atc 499
Phe Thr Cys Val Arg Glu Ala Phe Gly Tyr Phe Lys Glu Asn Gly Ile
120 125 130
gcg ggg cgc atc gtc acg att ggt tct ccc acc ggg cag cgc ggc aac 547
Ala Gly Arg Ile Val Thr Ile Gly Ser Pro Thr Gly Gln Arg Gly Asn
135 140 145
ttc gga cag agc aat tac gct gca gct aag gcg ggc att gtg ggt atg 595
Phe Gly Gln Ser Asn Tyr Ala Ala Ala Lys Ala Gly Ile Val Gly Met
150 155 160 165
gtt cgc acg tgg gcg ctg gag atg aag cgc gca ggt gtc acc att aac 643
Val Arg Thr Trp Ala Leu Glu Met Lys Arg Ala Gly Val Thr Ile Asn
170 175 180
gcg atc att ccg gaa gca gcc acc gat atg acc aag acg gtg cca tat 691
Ala Ile Ile Pro Glu Ala Ala Thr Asp Met Thr Lys Thr Val Pro Tyr
185 190 195
ttc cag aag gct gta gag gcc gat gag cgt ggc gag gcc atg cca gca 739
Phe Gln Lys Ala Val Glu Ala Asp Glu Arg Gly Glu Ala Met Pro Ala
200 205 210
ttc ttc cgc gag acc cta ggt ttt ggc act cct cag gat gtt gcg gga 787
Phe Phe Arg Glu Thr Leu Gly Phe Gly Thr Pro Gln Asp Val Ala Gly
215 220 225
ctt gtg gcc ttc ctt tcc tct gat gag gca gcg aat att tct gga cag 835
Leu Val Ala Phe Leu Ser Ser Asp Glu Ala Ala Asn Ile Ser Gly Gln
230 235 240 245
gcc atc ggt gca ggc ggc gac cgc atg cag gtg tgg aag cac cca gag 883
Ala Ile Gly Ala Gly Gly Asp Arg Met Gln Val Trp Lys His Pro Glu
250 255 260
cca gca gtt act gaa ttt aac cca ggt ggc tgg acc tat gaa gca ctg 931
Pro Ala Val Thr Glu Phe Asn Pro Gly Gly Trp Thr Tyr Glu Ala Leu
265 270 275
cag gaa cgt ggc aag aac att att gag ggc aac ctg cag tcc gtc ggt 979
Gln Glu Arg Gly Lys Asn Ile Ile Glu Gly Asn Leu Gln Ser Val Gly
280 285 290
gtc gtt ttc cct gaa ctg ccg gca gag ctt cag cca caa atc cca gtc 1027
Val Val Phe Pro Glu Leu Pro Ala Glu Leu Gln Pro Gln Ile Pro Val
295 300 305
aag gca taacaccgca caccaagaat ttt 1056
Lys Ala
310
<210> 28
<211> 311
<212> PRT
<213> Corynebacterium glutamicum
<400> 28
Met Ser Leu Asn Gly Lys Val Ala Ile Val Thr Gly Ser Gly Ala Gly
1 5 10 15
Leu Gly Arg Ser Phe Ala Gln Glu Leu Ala Arg Gln Gly Ala Ser Val
20 25 30
Ile Val Asn Asp Val Asn Gln Ala Ala Ala Asp Glu Thr Val Ala Ala
35 40 45
Ile Thr Glu Ala Gly Gly Lys Ala Ala Ala Val Ile Ala Pro Val Gly
50 55 60
Pro Ser Glu Ser Ala Ala Leu Leu Val Arg Glu Ala Val Asp Lys Phe
65 70 75 80
Gly Ser Leu Asp Ile Leu Val Thr Asn Ala Gly Ile Leu Arg Asp Arg
85 90 95
Ser Leu Leu Lys Met Thr Asp Asp Asp Phe Asp Ala Val Ile Asn Val
100 105 110
His Leu Lys Gly Thr Phe Thr Cys Val Arg Glu Ala Phe Gly Tyr Phe
115 120 125
Lys Glu Asn Gly Ile Ala Gly Arg Ile Val Thr Ile Gly Ser Pro Thr
130 135 140
Gly Gln Arg Gly Asn Phe Gly Gln Ser Asn Tyr Ala Ala Ala Lys Ala
145 150 155 160
Gly Ile Val Gly Met Val Arg Thr Trp Ala Leu Glu Met Lys Arg Ala
165 170 175
Gly Val Thr Ile Asn Ala Ile Ile Pro Glu Ala Ala Thr Asp Met Thr
180 185 190
Lys Thr Val Pro Tyr Phe Gln Lys Ala Val Glu Ala Asp Glu Arg Gly
195 200 205
Glu Ala Met Pro Ala Phe Phe Arg Glu Thr Leu Gly Phe Gly Thr Pro
210 215 220
Gln Asp Val Ala Gly Leu Val Ala Phe Leu Ser Ser Asp Glu Ala Ala
225 230 235 240
Asn Ile Ser Gly Gln Ala Ile Gly Ala Gly Gly Asp Arg Met Gln Val
245 250 255
Trp Lys His Pro Glu Pro Ala Val Thr Glu Phe Asn Pro Gly Gly Trp
260 265 270
Thr Tyr Glu Ala Leu Gln Glu Arg Gly Lys Asn Ile Ile Glu Gly Asn
275 280 285
Leu Gln Ser Val Gly Val Val Phe Pro Glu Leu Pro Ala Glu Leu Gln
290 295 300
Pro Gln Ile Pro Val Lys Ala
305 310
<210> 29
<211> 1827
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1804)
<223> RXN02487
<400> 29
tcatagctac gcgcatgccc acattctaga tcgccgaaga aagcagcggg acgtctctat 60
atactaaagg gcactaaagc aacgcagttg aagggacacc atg tca gca tac gaa 115
Met Ser Ala Tyr Glu
1 5
acc aaa gaa tgg ctc cag cac tac cca gag tgg acg cca cac tcg ctg 163
Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp Thr Pro His Ser Leu
10 15 20
gaa tat ggc gac acc acc ctg ctg gac gtt tac gac aac aac ctg gcc 211
Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr Asp Asn Asn Leu Ala
25 30 35
att aac gca gac aag cca gcc acc tac ttt ttc ggt cgt tca caa acc 259
Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe Gly Arg Ser Gln Thr
40 45 50
tac ggt gaa ctg gac aaa gaa gtc cgc aaa act gcc gct ggc ctg cgc 307
Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr Ala Ala Gly Leu Arg
55 60 65
gca cta ggt gtc cgc ccc ggc gat cac gta gcg att atc ctc ccc aac 355
Ala Leu Gly Val Arg Pro Gly Asp His Val Ala Ile Ile Leu Pro Asn
70 75 80 85
tgc cca cag cac atc gca gct ttc tac gca gtg ctg aaa ctc ggc gca 403
Cys Pro Gln His Ile Ala Ala Phe Tyr Ala Val Leu Lys Leu Gly Ala
90 95 100
gta gtc att gag cac aac ccg ctc tac acc gcc cac gaa ctg ctc gaa 451
Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala His Glu Leu Leu Glu
105 110 115
ccc ttc aaa gac cac ggt gcc cgc gtt gcc atc gtc tgg gac aaa gcc 499
Pro Phe Lys Asp His Gly Ala Arg Val Ala Ile Val Trp Asp Lys Ala
120 125 130
tcc ccc acc gtc gaa cag cta cgt gga cag acc cag ttg gaa acc atc 547
Ser Pro Thr Val Glu Gln Leu Arg Gly Gln Thr Gln Leu Glu Thr Ile
135 140 145
gtg tcg gtc aac atg atc aac gcg atg cca cca ctc cag cgc cta gca 595
Val Ser Val Asn Met Ile Asn Ala Met Pro Pro Leu Gln Arg Leu Ala
150 155 160 165
ctt cgg ctc cca atc cct gca ctg cgc aag agc cgc gaa tcc ctc tcc 643
Leu Arg Leu Pro Ile Pro Ala Leu Arg Lys Ser Arg Glu Ser Leu Ser
170 175 180
ggc gca gcc ccc aac acc gtt cct ttt gaa acc ctg acc agc gca gca 691
Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr Leu Thr Ser Ala Ala
185 190 195
atg ggc ggc gac ggc gac gac gta gtt tca gaa ccc acc gtg acc aaa 739
Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu Pro Thr Val Thr Lys
200 205 210
gaa tcc gtc gcg ctg atc ctc tac acc tcc ggc acc acc gga cgc ccc 787
Glu Ser Val Ala Leu Ile Leu Tyr Thr Ser Gly Thr Thr Gly Arg Pro
215 220 225
aag ggt gcc cag ctc acc cac gga aac ctg ttc ttc aat ctt ctt caa 835
Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe Phe Asn Leu Leu Gln
230 235 240 245
gga aag cac tgg gtt cca ggt ctc gga gac aaa cca gaa cgc atg ctt 883
Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys Pro Glu Arg Met Leu
250 255 260
gca gcc cta cca atg ttc cac gca tac ggt ctg acc atg gtc ggc aca 931
Ala Ala Leu Pro Met Phe His Ala Tyr Gly Leu Thr Met Val Gly Thr
265 270 275
ctg tcc gtg ttc atc ggt ggc gaa atg gtg cta ctt ccc acc cca cgc 979
Leu Ser Val Phe Ile Gly Gly Glu Met Val Leu Leu Pro Thr Pro Arg
280 285 290
atc gac ctg atc atg aac gta atg aaa aag cac acc cca acc tgg cta 1027
Ile Asp Leu Ile Met Asn Val Met Lys Lys His Thr Pro Thr Trp Leu
295 300 305
cca ggc gtg ccc acc ctt tac gaa aaa atc gtc gac gcc tcc gaa aaa 1075
Pro Gly Val Pro Thr Leu Tyr Glu Lys Ile Val Asp Ala Ser Glu Lys
310 315 320 325
gaa gga atc ccc atc aag gga gtc cgc aac gcc ttc tcc ggt gca tcc 1123
Glu Gly Ile Pro Ile Lys Gly Val Arg Asn Ala Phe Ser Gly Ala Ser
330 335 340
aca ctc tcc cag cgc acc gtt gaa cgc tgg gaa aag cac acc ggc gga 1171
Thr Leu Ser Gln Arg Thr Val Glu Arg Trp Glu Lys His Thr Gly Gly
345 350 355
cgc ctc gtc gaa ggc tac ggc ctc acc gaa acc tcc ccc atc atc gtg 1219
Arg Leu Val Glu Gly Tyr Gly Leu Thr Glu Thr Ser Pro Ile Ile Val
360 365 370
ggt aac ccc atg agc gat cac cga cgc caa ggc tac gta gga atc ccc 1267
Gly Asn Pro Met Ser Asp His Arg Arg Gln Gly Tyr Val Gly Ile Pro
375 380 385
ttc ccc gac acc atc gtg cgc atc gca aac cca gaa aac ctc gac gaa 1315
Phe Pro Asp Thr Ile Val Arg Ile Ala Asn Pro Glu Asn Leu Asp Glu
390 395 400 405
acc atg ccc gac ggc agc gaa ggc gaa gtc cta gtc aag ggc cca cag 1363
Thr Met Pro Asp Gly Ser Glu Gly Glu Val Leu Val Lys Gly Pro Gln
410 415 420
gtg ttc aag ggt tac ctc aac cag gaa gaa gcc acc aag aac agc ttc 1411
Val Phe Lys Gly Tyr Leu Asn Gln Glu Glu Ala Thr Lys Asn Ser Phe
425 430 435
cac ggc gag tgg tac cgc acc ggc gac gtc gga gtg atg gaa gaa gac 1459
His Gly Glu Trp Tyr Arg Thr Gly Asp Val Gly Val Met Glu Glu Asp
440 445 450
ggg ttc atc cgc cta gtt gct cgc atc aag gaa gtc atc atc act ggc 1507
Gly Phe Ile Arg Leu Val Ala Arg Ile Lys Glu Val Ile Ile Thr Gly
455 460 465
ggt ttc aac gtg tac cca gct gag gtt gaa gaa gtc ctc gca gag cac 1555
Gly Phe Asn Val Tyr Pro Ala Glu Val Glu Glu Val Leu Ala Glu His
470 475 480 485
cca gac att gaa gat tcc gca gtc gtt ggt atc ccg cgt gaa gac ggc 1603
Pro Asp Ile Glu Asp Ser Ala Val Val Gly Ile Pro Arg Glu Asp Gly
490 495 500
tcc gaa aac gtc gtt gct gcc atc act ttg gtg gaa ggt gca gcg ctg 1651
Ser Glu Asn Val Val Ala Ala Ile Thr Leu Val Glu Gly Ala Ala Leu
505 510 515
gat ccg gat ggc ctg aag gaa ttc gcc cgc aag aac ctc acc cgc tac 1699
Asp Pro Asp Gly Leu Lys Glu Phe Ala Arg Lys Asn Leu Thr Arg Tyr
520 525 530
aag gtt ccg cgc act ttc tac cac ttt gag gag atg ccg cgg gat cag 1747
Lys Val Pro Arg Thr Phe Tyr His Phe Glu Glu Met Pro Arg Asp Gln
535 540 545
atg ggc aag att agg cgt cgt gaa gtg cag gcg gag ttg ttg aag aag 1795
Met Gly Lys Ile Arg Arg Arg Glu Val Gln Ala Glu Leu Leu Lys Lys
550 555 560 565
ctc ggc aag tagacgccga tttaagaggt cga 1827
Leu Gly Lys
<210> 30
<211> 568
<212> PRT
<213> Corynebacterium glutamicum
<400> 30
Met Ser Ala Tyr Glu Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp
1 5 10 15
Thr Pro His Ser Leu Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr
20 25 30
Asp Asn Asn Leu Ala Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe
35 40 45
Gly Arg Ser Gln Thr Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr
50 55 60
Ala Ala Gly Leu Arg Ala Leu Gly Val Arg Pro Gly Asp His Val Ala
65 70 75 80
Ile Ile Leu Pro Asn Cys Pro Gln His Ile Ala Ala Phe Tyr Ala Val
85 90 95
Leu Lys Leu Gly Ala Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala
100 105 110
His Glu Leu Leu Glu Pro Phe Lys Asp His Gly Ala Arg Val Ala Ile
115 120 125
Val Trp Asp Lys Ala Ser Pro Thr Val Glu Gln Leu Arg Gly Gln Thr
130 135 140
Gln Leu Glu Thr Ile Val Ser Val Asn Met Ile Asn Ala Met Pro Pro
145 150 155 160
Leu Gln Arg Leu Ala Leu Arg Leu Pro Ile Pro Ala Leu Arg Lys Ser
165 170 175
Arg Glu Ser Leu Ser Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr
180 185 190
Leu Thr Ser Ala Ala Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu
195 200 205
Pro Thr Val Thr Lys Glu Ser Val Ala Leu Ile Leu Tyr Thr Ser Gly
210 215 220
Thr Thr Gly Arg Pro Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe
225 230 235 240
Phe Asn Leu Leu Gln Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys
245 250 255
Pro Glu Arg Met Leu Ala Ala Leu Pro Met Phe His Ala Tyr Gly Leu
260 265 270
Thr Met Val Gly Thr Leu Ser Val Phe Ile Gly Gly Glu Met Val Leu
275 280 285
Leu Pro Thr Pro Arg Ile Asp Leu Ile Met Asn Val Met Lys Lys His
290 295 300
Thr Pro Thr Trp Leu Pro Gly Val Pro Thr Leu Tyr Glu Lys Ile Val
305 310 315 320
Asp Ala Ser Glu Lys Glu Gly Ile Pro Ile Lys Gly Val Arg Asn Ala
325 330 335
Phe Ser Gly Ala Ser Thr Leu Ser Gln Arg Thr Val Glu Arg Trp Glu
340 345 350
Lys His Thr Gly Gly Arg Leu Val Glu Gly Tyr Gly Leu Thr Glu Thr
355 360 365
Ser Pro Ile Ile Val Gly Asn Pro Met Ser Asp His Arg Arg Gln Gly
370 375 380
Tyr Val Gly Ile Pro Phe Pro Asp Thr Ile Val Arg Ile Ala Asn Pro
385 390 395 400
Glu Asn Leu Asp Glu Thr Met Pro Asp Gly Ser Glu Gly Glu Val Leu
405 410 415
Val Lys Gly Pro Gln Val Phe Lys Gly Tyr Leu Asn Gln Glu Glu Ala
420 425 430
Thr Lys Asn Ser Phe His Gly Glu Trp Tyr Arg Thr Gly Asp Val Gly
435 440 445
Val Met Glu Glu Asp Gly Phe Ile Arg Leu Val Ala Arg Ile Lys Glu
450 455 460
Val Ile Ile Thr Gly Gly Phe Asn Val Tyr Pro Ala Glu Val Glu Glu
465 470 475 480
Val Leu Ala Glu His Pro Asp Ile Glu Asp Ser Ala Val Val Gly Ile
485 490 495
Pro Arg Glu Asp Gly Ser Glu Asn Val Val Ala Ala Ile Thr Leu Val
500 505 510
Glu Gly Ala Ala Leu Asp Pro Asp Gly Leu Lys Glu Phe Ala Arg Lys
515 520 525
Asn Leu Thr Arg Tyr Lys Val Pro Arg Thr Phe Tyr His Phe Glu Glu
530 535 540
Met Pro Arg Asp Gln Met Gly Lys Ile Arg Arg Arg Glu Val Gln Ala
545 550 555 560
Glu Leu Leu Lys Lys Leu Gly Lys
565
<210> 31
<211> 411
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(388)
<223> FRXA02487
<400> 31
ggcgagtggt accgcaccgc gacgtcggag tgatgaagaa gccgggttca tccgcctagt 60
tgctcgcatc aagaaagtca tcatcactgg cggtttcaac gtg tac cca gct gag 115
Val Tyr Pro Ala Glu
1 5
gtt gaa gaa gtc ctc gca gag cac cca gac att gaa gat tcc gca gtc 163
Val Glu Glu Val Leu Ala Glu His Pro Asp Ile Glu Asp Ser Ala Val
10 15 20
gtt ggt atc ccg cgt gaa gac ggc tcc gaa aac gtc gtt gct gcc atc 211
Val Gly Ile Pro Arg Glu Asp Gly Ser Glu Asn Val Val Ala Ala Ile
25 30 35
act ttg gtg gaa ggt gca gcg ctg gat ccg gat ggc ctg aag gaa ttc 259
Thr Leu Val Glu Gly Ala Ala Leu Asp Pro Asp Gly Leu Lys Glu Phe
40 45 50
gcc cgc aag aac ctc acc cgc tac aag gtt ccg cgc act ttc tac cac 307
Ala Arg Lys Asn Leu Thr Arg Tyr Lys Val Pro Arg Thr Phe Tyr His
55 60 65
ttt gag gag atg ccg cgg gat cag atg ggc aag att agg cgt cgt gaa 355
Phe Glu Glu Met Pro Arg Asp Gln Met Gly Lys Ile Arg Arg Arg Glu
70 75 80 85
gtg cag gcg gag ttg ttg aag aag ctc ggc aag tagacgccga tttaagaggt 408
Val Gln Ala Glu Leu Leu Lys Lys Leu Gly Lys
90 95
cga 411
<210> 32
<211> 96
<212> PRT
<213> Corynebacterium glutamicum
<400> 32
Val Tyr Pro Ala Glu Val Glu Glu Val Leu Ala Glu His Pro Asp Ile
1 5 10 15
Glu Asp Ser Ala Val Val Gly Ile Pro Arg Glu Asp Gly Ser Glu Asn
20 25 30
Val Val Ala Ala Ile Thr Leu Val Glu Gly Ala Ala Leu Asp Pro Asp
35 40 45
Gly Leu Lys Glu Phe Ala Arg Lys Asn Leu Thr Arg Tyr Lys Val Pro
50 55 60
Arg Thr Phe Tyr His Phe Glu Glu Met Pro Arg Asp Gln Met Gly Lys
65 70 75 80
Ile Arg Arg Arg Glu Val Gln Ala Glu Leu Leu Lys Lys Leu Gly Lys
85 90 95
<210> 33
<211> 913
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(913)
<223> FRXA02490
<400> 33
tcatagctac gcgcatgccc acattctaga tcgccgaaga aagcagcggg acgtctctat 60
atactaaagg gcactaaagc aacgcagttg aagggacacc atg tca gca tac gaa 115
Met Ser Ala Tyr Glu
1 5
acc aaa gaa tgg ctc cag cac tac cca gag tgg acg cca cac tcg ctg 163
Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp Thr Pro His Ser Leu
10 15 20
gaa tat ggc gac acc acc ctg ctg gac gtt tac gac aac aac ctg gcc 211
Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr Asp Asn Asn Leu Ala
25 30 35
att aac gca gac aag cca gcc acc tac ttt ttc ggt cgt tca caa acc 259
Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe Gly Arg Ser Gln Thr
40 45 50
tac ggt gaa ctg gac aaa gaa gtc cgc aaa act gcc gct ggc ctg cgc 307
Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr Ala Ala Gly Leu Arg
55 60 65
gca cta ggt gtc cgc ccc ggc gat cac gta gcg att atc ctc ccc aac 355
Ala Leu Gly Val Arg Pro Gly Asp His Val Ala Ile Ile Leu Pro Asn
70 75 80 85
tgc cca cag cac atc gca gct ttc tac gca gtg ctg aaa ctc ggc gca 403
Cys Pro Gln His Ile Ala Ala Phe Tyr Ala Val Leu Lys Leu Gly Ala
90 95 100
gta gtc att gag cac aac ccg ctc tac acc gcc cac gaa ctg ctc gaa 451
Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala His Glu Leu Leu Glu
105 110 115
ccc ttc aaa gac cac ggt gcc cgc gtt gcc atc gtc tgg gac aaa gcc 499
Pro Phe Lys Asp His Gly Ala Arg Val Ala Ile Val Trp Asp Lys Ala
120 125 130
tcc ccc acc gtc gaa cag cta cgt gga cag acc cag ttg gaa acc atc 547
Ser Pro Thr Val Glu Gln Leu Arg Gly Gln Thr Gln Leu Glu Thr Ile
135 140 145
gtg tcg gtc aac atg atc aac gcg atg cca cca ctc cag cgc cta gca 595
Val Ser Val Asn Met Ile Asn Ala Met Pro Pro Leu Gln Arg Leu Ala
150 155 160 165
ctt cgg ctc cca atc cct gca ctg cgc aag agc cgc gaa tcc ctc tcc 643
Leu Arg Leu Pro Ile Pro Ala Leu Arg Lys Ser Arg Glu Ser Leu Ser
170 175 180
ggc gca gcc ccc aac acc gtt cct ttt gaa acc ctg acc agc gca gca 691
Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr Leu Thr Ser Ala Ala
185 190 195
atg ggc ggc gac ggc gac gac gta gtt tca gaa ccc acc gtg acc aaa 739
Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu Pro Thr Val Thr Lys
200 205 210
gaa tcc gtc gcg ctg atc ctc tac acc tcc ggc acc acc gga cgc ccc 787
Glu Ser Val Ala Leu Ile Leu Tyr Thr Ser Gly Thr Thr Gly Arg Pro
215 220 225
aag ggt gcc cag ctc acc cac gga aac ctg ttc tcc aat ctc ctc caa 835
Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe Ser Asn Leu Leu Gln
230 235 240 245
gga aag cac tgg gtt cca ggt ctc gga gac aaa cca gaa cgc atg ctt 883
Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys Pro Glu Arg Met Leu
250 255 260
gca gcc cta cca atg ttc cac gca tac ggt 913
Ala Ala Leu Pro Met Phe His Ala Tyr Gly
265 270
<210> 34
<211> 271
<212> PRT
<213> Corynebacterium glutamicum
<400> 34
Met Ser Ala Tyr Glu Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp
1 5 10 15
Thr Pro His Ser Leu Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr
20 25 30
Asp Asn Asn Leu Ala Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe
35 40 45
Gly Arg Ser Gln Thr Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr
50 55 60
Ala Ala Gly Leu Arg Ala Leu Gly Val Arg Pro Gly Asp His Val Ala
65 70 75 80
Ile Ile Leu Pro Asn Cys Pro Gln His Ile Ala Ala Phe Tyr Ala Val
85 90 95
Leu Lys Leu Gly Ala Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala
100 105 110
His Glu Leu Leu Glu Pro Phe Lys Asp His Gly Ala Arg Val Ala Ile
115 120 125
Val Trp Asp Lys Ala Ser Pro Thr Val Glu Gln Leu Arg Gly Gln Thr
130 135 140
Gln Leu Glu Thr Ile Val Ser Val Asn Met Ile Asn Ala Met Pro Pro
145 150 155 160
Leu Gln Arg Leu Ala Leu Arg Leu Pro Ile Pro Ala Leu Arg Lys Ser
165 170 175
Arg Glu Ser Leu Ser Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr
180 185 190
Leu Thr Ser Ala Ala Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu
195 200 205
Pro Thr Val Thr Lys Glu Ser Val Ala Leu Ile Leu Tyr Thr Ser Gly
210 215 220
Thr Thr Gly Arg Pro Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe
225 230 235 240
Ser Asn Leu Leu Gln Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys
245 250 255
Pro Glu Arg Met Leu Ala Ala Leu Pro Met Phe His Ala Tyr Gly
260 265 270
<210> 35
<211> 414
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(391)
<223> RXA01467
<400> 35
gcgtcatctt tagccttgct ttatgagctt ttccccgcaa tgagccgcgt tgtgtatcca 60
taagtcttag cctacaagcg ctttgaggta gtttgggatc atg gat ttc aac gac 115
Met Asp Phe Asn Asp
1 5
aaa gcc gct tca gaa aac gct gta aag act ggc gca gaa ggc ccc aac 163
Lys Ala Ala Ser Glu Asn Ala Val Lys Thr Gly Ala Glu Gly Pro Asn
10 15 20
gtt ttc gcg agc gtg gcc aag att ttg cag gat gtt ggc gga att tca 211
Val Phe Ala Ser Val Ala Lys Ile Leu Gln Asp Val Gly Gly Ile Ser
25 30 35
gcc gaa gac gtc act ccg gaa tct cgt ttt act gag gat ttg gca gtg 259
Ala Glu Asp Val Thr Pro Glu Ser Arg Phe Thr Glu Asp Leu Ala Val
40 45 50
agc tca ctc aat tac atc gag ttg att gtc aat gcg gag gac gca ttt 307
Ser Ser Leu Asn Tyr Ile Glu Leu Ile Val Asn Ala Glu Asp Ala Phe
55 60 65
ggt gtt cgc att gag gac gcc gat gcc aag gat ttg acc acc gtg cag 355
Gly Val Arg Ile Glu Asp Ala Asp Ala Lys Asp Leu Thr Thr Val Gln
70 75 80 85
gat ttg att gac ttt att aac acc aat aag gct gat tagcgggaaa 401
Asp Leu Ile Asp Phe Ile Asn Thr Asn Lys Ala Asp
90 95
atttcgccca aaa 414
<210> 36
<211> 97
<212> PRT
<213> Corynebacterium glutamicum
<400> 36
Met Asp Phe Asn Asp Lys Ala Ala Ser Glu Asn Ala Val Lys Thr Gly
1 5 10 15
Ala Glu Gly Pro Asn Val Phe Ala Ser Val Ala Lys Ile Leu Gln Asp
20 25 30
Val Gly Gly Ile Ser Ala Glu Asp Val Thr Pro Glu Ser Arg Phe Thr
35 40 45
Glu Asp Leu Ala Val Ser Ser Leu Asn Tyr Ile Glu Leu Ile Val Asn
50 55 60
Ala Glu Asp Ala Phe Gly Val Arg Ile Glu Asp Ala Asp Ala Lys Asp
65 70 75 80
Leu Thr Thr Val Gln Asp Leu Ile Asp Phe Ile Asn Thr Asn Lys Ala
85 90 95
Asp
<210> 37
<211> 298
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(298)
<223> RXA00796
<400> 37
ctggaatccc aaagcgcttg catgacgcgg aaagttaaca taggctaggt acgtcaagtt 60
gttgatacat caacttaatt aacttttaga ggagtacacc atg agc aag atc gcc 115
Met Ser Lys Ile Ala
1 5
atc atc acc ggt tcc acc cgt cca ggc cgc gtc aac att gac gta gcc 163
Ile Ile Thr Gly Ser Thr Arg Pro Gly Arg Val Asn Ile Asp Val Ala
10 15 20
aac tgg gtt ctc gag cgc gca caa gag cgc aac gat gca cag tac gag 211
Asn Trp Val Leu Glu Arg Ala Gln Glu Arg Asn Asp Ala Gln Tyr Glu
25 30 35
ctc gtt gat atc gcc gat ttc aac ttc ccc gtc ctc gac gaa gca atg 259
Leu Val Asp Ile Ala Asp Phe Asn Phe Pro Val Leu Asp Glu Ala Met
40 45 50
cca gcc ggc tac ggc cag tat gca aac gag cac acc aag 298
Pro Ala Gly Tyr Gly Gln Tyr Ala Asn Glu His Thr Lys
55 60 65
<210> 38
<211> 66
<212> PRT
<213> Corynebacterium glutamicum
<400> 38
Met Ser Lys Ile Ala Ile Ile Thr Gly Ser Thr Arg Pro Gly Arg Val
1 5 10 15
Asn Ile Asp Val Ala Asn Trp Val Leu Glu Arg Ala Gln Glu Arg Asn
20 25 30
Asp Ala Gln Tyr Glu Leu Val Asp Ile Ala Asp Phe Asn Phe Pro Val
35 40 45
Leu Asp Glu Ala Met Pro Ala Gly Tyr Gly Gln Tyr Ala Asn Glu His
50 55 60
Thr Lys
65
<210> 39
<211> 666
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(643)
<223> RXA01897
<400> 39
ctatttagat cgttccggaa ccgatccacg cgccgatatc cactccctgg atgaactctt 60
tcactaggct ggcctttatt gtttccggaa aggggttgct atg aaa att ggt gtc 115
Met Lys Ile Gly Val
1 5
atc ctg ggc agt atc cgc gaa ggc cgc ttc ggc caa ggc gtt gcc gat 163
Ile Leu Gly Ser Ile Arg Glu Gly Arg Phe Gly Gln Gly Val Ala Asp
10 15 20
tgg gtc atg gaa caa atc ggg gct tat gac gca ccc gat gtg gaa ttt 211
Trp Val Met Glu Gln Ile Gly Ala Tyr Asp Ala Pro Asp Val Glu Phe
25 30 35
gaa ctc atc gac ctc aaa gct ttc aac gtg ccc ctg ttg gaa tcc gcg 259
Glu Leu Ile Asp Leu Lys Ala Phe Asn Val Pro Leu Leu Glu Ser Ala
40 45 50
aca gtt cca ggt tcc gcg gat aaa cag tac gac gac ccg cgc gta act 307
Thr Val Pro Gly Ser Ala Asp Lys Gln Tyr Asp Asp Pro Arg Val Thr
55 60 65
gcc tgg tca cag gcc att gat gcc tgc gat gcc ttc ctt ttc atc acc 355
Ala Trp Ser Gln Ala Ile Asp Ala Cys Asp Ala Phe Leu Phe Ile Thr
70 75 80 85
ccg gaa tac aac cac ggt gtg ccc ggc gcg ttc aaa aat gcg tat gac 403
Pro Glu Tyr Asn His Gly Val Pro Gly Ala Phe Lys Asn Ala Tyr Asp
90 95 100
atc ctg ggc aat gaa tgg ctg aac aaa acc gtc ggt ttc att tcc tac 451
Ile Leu Gly Asn Glu Trp Leu Asn Lys Thr Val Gly Phe Ile Ser Tyr
105 110 115
ggt gca gtc gaa ggg atc cgt gtt gtc gaa cag tgg cgt cag atc gtc 499
Gly Ala Val Glu Gly Ile Arg Val Val Glu Gln Trp Arg Gln Ile Val
120 125 130
gcc acc ttc aac atg tac gat atc cgc agc cag cta tcc ttt tcc acc 547
Ala Thr Phe Asn Met Tyr Asp Ile Arg Ser Gln Leu Ser Phe Ser Thr
135 140 145
ttc acc gag aac aac aac ggc act ttt gcg ccc aat gat cga cgc ccc 595
Phe Thr Glu Asn Asn Asn Gly Thr Phe Ala Pro Asn Asp Arg Arg Pro
150 155 160 165
ggt gaa cta atc cgc ctc ctt gat agc ctc cta acg gct gtc cgc gat 643
Gly Glu Leu Ile Arg Leu Leu Asp Ser Leu Leu Thr Ala Val Arg Asp
170 175 180
taaggctctg aaatactaat gag 666
<210> 40
<211> 181
<212> PRT
<213> Corynebacterium glutamicum
<400> 40
Met Lys Ile Gly Val Ile Leu Gly Ser Ile Arg Glu Gly Arg Phe Gly
1 5 10 15
Gln Gly Val Ala Asp Trp Val Met Glu Gln Ile Gly Ala Tyr Asp Ala
20 25 30
Pro Asp Val Glu Phe Glu Leu Ile Asp Leu Lys Ala Phe Asn Val Pro
35 40 45
Leu Leu Glu Ser Ala Thr Val Pro Gly Ser Ala Asp Lys Gln Tyr Asp
50 55 60
Asp Pro Arg Val Thr Ala Trp Ser Gln Ala Ile Asp Ala Cys Asp Ala
65 70 75 80
Phe Leu Phe Ile Thr Pro Glu Tyr Asn His Gly Val Pro Gly Ala Phe
85 90 95
Lys Asn Ala Tyr Asp Ile Leu Gly Asn Glu Trp Leu Asn Lys Thr Val
100 105 110
Gly Phe Ile Ser Tyr Gly Ala Val Glu Gly Ile Arg Val Val Glu Gln
115 120 125
Trp Arg Gln Ile Val Ala Thr Phe Asn Met Tyr Asp Ile Arg Ser Gln
130 135 140
Leu Ser Phe Ser Thr Phe Thr Glu Asn Asn Asn Gly Thr Phe Ala Pro
145 150 155 160
Asn Asp Arg Arg Pro Gly Glu Leu Ile Arg Leu Leu Asp Ser Leu Leu
165 170 175
Thr Ala Val Arg Asp
180
<210> 41
<211> 375
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(375)
<223> RXN02809
<400> 41
aac ctc tcc gtc cca gca gca cta acc aac gcc ctt tcc tac ctc tcc 48
Asn Leu Ser Val Pro Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser
1 5 10 15
gca gag tgg aac aac aag gct gca ggc atc gtc tcc tac ggc tcc gca 96
Ala Glu Trp Asn Asn Lys Ala Ala Gly Ile Val Ser Tyr Gly Ser Ala
20 25 30
atg ggc gtt cgc gca gct gag cac ctc cgc ggc atc ctt tcc gag ctt 144
Met Gly Val Arg Ala Ala Glu His Leu Arg Gly Ile Leu Ser Glu Leu
35 40 45
cag atc gca cac gtt caa aag acc ggc ctg ctg agc atc ttc acc gac 192
Gln Ile Ala His Val Gln Lys Thr Gly Leu Leu Ser Ile Phe Thr Asp
50 55 60
ttc gaa tac cct aac ttc aag cct tcc gag cag ggc atc tcc tct gtg 240
Phe Glu Tyr Pro Asn Phe Lys Pro Ser Glu Gln Gly Ile Ser Ser Val
65 70 75 80
gac gct atg ctt gag cag ctt gtt gtc tgg acc aag gca atg tcc acc 288
Asp Ala Met Leu Glu Gln Leu Val Val Trp Thr Lys Ala Met Ser Thr
85 90 95
att cgc gag tct gcg aac gtc tat cac tta aga acc cct cac aaa agt 336
Ile Arg Glu Ser Ala Asn Val Tyr His Leu Arg Thr Pro His Lys Ser
100 105 110
ggc gag ctc ccc gac tgg gac tcg cct ctt ttc gta ttc 375
Gly Glu Leu Pro Asp Trp Asp Ser Pro Leu Phe Val Phe
115 120 125
<210> 42
<211> 125
<212> PRT
<213> Corynebacterium glutamicum
<400> 42
Asn Leu Ser Val Pro Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser
1 5 10 15
Ala Glu Trp Asn Asn Lys Ala Ala Gly Ile Val Ser Tyr Gly Ser Ala
20 25 30
Met Gly Val Arg Ala Ala Glu His Leu Arg Gly Ile Leu Ser Glu Leu
35 40 45
Gln Ile Ala His Val Gln Lys Thr Gly Leu Leu Ser Ile Phe Thr Asp
50 55 60
Phe Glu Tyr Pro Asn Phe Lys Pro Ser Glu Gln Gly Ile Ser Ser Val
65 70 75 80
Asp Ala Met Leu Glu Gln Leu Val Val Trp Thr Lys Ala Met Ser Thr
85 90 95
Ile Arg Glu Ser Ala Asn Val Tyr His Leu Arg Thr Pro His Lys Ser
100 105 110
Gly Glu Leu Pro Asp Trp Asp Ser Pro Leu Phe Val Phe
115 120 125
<210> 43
<211> 273
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(273)
<223> FRXA02809
<400> 43
gca gca cta acc aac gcc ctt tcc tac ctc tcc gca gag tgg aac aac 48
Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser Ala Glu Trp Asn Asn
1 5 10 15
aag gct gca ggc atc gtc tcc tac ggc tcc gca atg ggc gtt cgc gca 96
Lys Ala Ala Gly Ile Val Ser Tyr Gly Ser Ala Met Gly Val Arg Ala
20 25 30
gct gag cac ctc cgc ggc atc ctt tcc gag ctt cag atc gca cac gtt 144
Ala Glu His Leu Arg Gly Ile Leu Ser Glu Leu Gln Ile Ala His Val
35 40 45
caa aag acc ggc ctg ctg agc atc ttc acc gac ttc gaa tac cct aac 192
Gln Lys Thr Gly Leu Leu Ser Ile Phe Thr Asp Phe Glu Tyr Pro Asn
50 55 60
ttc aag cct tcc gag cag ggc atc tcc tct gtg gac gct atg ctt gag 240
Phe Lys Pro Ser Glu Gln Gly Ile Ser Ser Val Asp Ala Met Leu Glu
65 70 75 80
cag ctt gtt gtc tgg acc aag gca atg tcc acc 273
Gln Leu Val Val Trp Thr Lys Ala Met Ser Thr
85 90
<210> 44
<211> 91
<212> PRT
<213> Corynebacterium glutamicum
<400> 44
Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser Ala Glu Trp Asn Asn
1 5 10 15
Lys Ala Ala Gly Ile Val Ser Tyr Gly Ser Ala Met Gly Val Arg Ala
20 25 30
Ala Glu His Leu Arg Gly Ile Leu Ser Glu Leu Gln Ile Ala His Val
35 40 45
Gln Lys Thr Gly Leu Leu Ser Ile Phe Thr Asp Phe Glu Tyr Pro Asn
50 55 60
Phe Lys Pro Ser Glu Gln Gly Ile Ser Ser Val Asp Ala Met Leu Glu
65 70 75 80
Gln Leu Val Val Trp Thr Lys Ala Met Ser Thr
85 90
<210> 45
<211> 5745
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(5722)
<223> RXN00113
<400> 45
tctgcgcatc ccactcgagg agctggcaaa cggccgcacc atcgatgttg aggcacgcac 60
cgactccatc gaagagtccg catccggccg tatcgttacc gtg cgc atc gtg ctc 115
Val Arg Ile Val Leu
1 5
acc acc gaa ggc gaa gta gca gcc aag ctg gtt acc cgc ttc gca att 163
Thr Thr Glu Gly Glu Val Ala Ala Lys Leu Val Thr Arg Phe Ala Ile
10 15 20
cgt gga cgc atc acc acc aac gaa atg gct gca cca gca gat tcc tac 211
Arg Gly Arg Ile Thr Thr Asn Glu Met Ala Ala Pro Ala Asp Ser Tyr
25 30 35
ggc gca cgc gac gaa gtt gtc gag gca acc cct cgt tcc ttc atc cgc 259
Gly Ala Arg Asp Glu Val Val Glu Ala Thr Pro Arg Ser Phe Ile Arg
40 45 50
cag gca act gtt tct gca cct gca gac atg acc cca ttc gcc atg gtt 307
Gln Ala Thr Val Ser Ala Pro Ala Asp Met Thr Pro Phe Ala Met Val
55 60 65
tct ggt gac tac aac cca att cac acc tct gac aac gct gca aag ctt 355
Ser Gly Asp Tyr Asn Pro Ile His Thr Ser Asp Asn Ala Ala Lys Leu
70 75 80 85
gtt ggc ctg gac gca gct ctt gtc cac ggc atg tgg ctg tcc gct acc 403
Val Gly Leu Asp Ala Ala Leu Val His Gly Met Trp Leu Ser Ala Thr
90 95 100
gca cag cac ctc gct ggt ctt ggc tct gag gtc att ggt tgg acc tac 451
Ala Gln His Leu Ala Gly Leu Gly Ser Glu Val Ile Gly Trp Thr Tyr
105 110 115
tcc atg tac ggc atg gtt caa ctc aac gac gtt gtt gac atc acc gtc 499
Ser Met Tyr Gly Met Val Gln Leu Asn Asp Val Val Asp Ile Thr Val
120 125 130
gag cgt gtt ggc cgc gca ggt ctg aag cct gca tac gag gtc acc tgc 547
Glu Arg Val Gly Arg Ala Gly Leu Lys Pro Ala Tyr Glu Val Thr Cys
135 140 145
cgc att gat ggc aac gtt gtc tcc cgc gga cag gca ctg ctc aag gct 595
Arg Ile Asp Gly Asn Val Val Ser Arg Gly Gln Ala Leu Leu Lys Ala
150 155 160 165
cct tcc acc gct tat gtt tac cca agc cag ggc atc cag gct aag ggc 643
Pro Ser Thr Ala Tyr Val Tyr Pro Ser Gln Gly Ile Gln Ala Lys Gly
170 175 180
atg ggc caa ggc gat cgc acc gca agc gca gag gct cgc gct gtg tgg 691
Met Gly Gln Gly Asp Arg Thr Ala Ser Ala Glu Ala Arg Ala Val Trp
185 190 195
gag cgt gca gat gca cac acc cgc gca aac ctg ggc ttc tcc atc cag 739
Glu Arg Ala Asp Ala His Thr Arg Ala Asn Leu Gly Phe Ser Ile Gln
200 205 210
cag gtc att gat gaa aac cca act gag ctg aag gtc ggg gac acc acc 787
Gln Val Ile Asp Glu Asn Pro Thr Glu Leu Lys Val Gly Asp Thr Thr
215 220 225
ttc gtg cac cca gct ggg gtt ttg aac ctc acc cag ttc acg cag gtc 835
Phe Val His Pro Ala Gly Val Leu Asn Leu Thr Gln Phe Thr Gln Val
230 235 240 245
gcg ctc gcc gtg gtt gcc tac gct cag acc gag cgc ctc aag gct gca 883
Ala Leu Ala Val Val Ala Tyr Ala Gln Thr Glu Arg Leu Lys Ala Ala
250 255 260
aac gca att gtc gac ggc tcc ctc tac gca ggc cac tcc ctc ggc gag 931
Asn Ala Ile Val Asp Gly Ser Leu Tyr Ala Gly His Ser Leu Gly Glu
265 270 275
tac acc gca ctg gca tcc ttg ggc aac atc ttc gaa ctc gaa ggc gtc 979
Tyr Thr Ala Leu Ala Ser Leu Gly Asn Ile Phe Glu Leu Glu Gly Val
280 285 290
atc gac gtt gtg ttc tcc cgc ggt tcc gca atg cac tcc ctg gtt cca 1027
Ile Asp Val Val Phe Ser Arg Gly Ser Ala Met His Ser Leu Val Pro
295 300 305
cgt gat gag aag ggc cgt tcc aac tac ggt ctt gcc gca ttc cgt ccg 1075
Arg Asp Glu Lys Gly Arg Ser Asn Tyr Gly Leu Ala Ala Phe Arg Pro
310 315 320 325
aac atg atc aac gtt gca gcc acc gag gtg gag aac tgg gtt gac cgt 1123
Asn Met Ile Asn Val Ala Ala Thr Glu Val Glu Asn Trp Val Asp Arg
330 335 340
gtc gct gaa gaa tcc ggc gaa ttc ctg cag atc gtt aac tac aac gtt 1171
Val Ala Glu Glu Ser Gly Glu Phe Leu Gln Ile Val Asn Tyr Asn Val
345 350 355
gat ggc cag cag tac gca gtc gca ggt acc ttg gct ggc ctg aag gcc 1219
Asp Gly Gln Gln Tyr Ala Val Ala Gly Thr Leu Ala Gly Leu Lys Ala
360 365 370
ctc aag gct tct gca tct gca aac cca cgt gct tac gtg aac att cca 1267
Leu Lys Ala Ser Ala Ser Ala Asn Pro Arg Ala Tyr Val Asn Ile Pro
375 380 385
ggc att gac gtg cca ttc cac tcc agc gtc ctg cgc cca ggc gtt cct 1315
Gly Ile Asp Val Pro Phe His Ser Ser Val Leu Arg Pro Gly Val Pro
390 395 400 405
gct ttc gca gag aag ctg gac gag ctg ctg cca gag acc atc gac att 1363
Ala Phe Ala Glu Lys Leu Asp Glu Leu Leu Pro Glu Thr Ile Asp Ile
410 415 420
gat gct ctt cgc ggc cgc tac atc ccg aac ctg gtt gct cgt cct ttc 1411
Asp Ala Leu Arg Gly Arg Tyr Ile Pro Asn Leu Val Ala Arg Pro Phe
425 430 435
gag ctc acc cag agc ttc gtg gat gcc atc ctt gct gtt gtt cca tcc 1459
Glu Leu Thr Gln Ser Phe Val Asp Ala Ile Leu Ala Val Val Pro Ser
440 445 450
gag cgc ctc aag ggc atc aag gtg gag gac acc gac gag aac acc ctg 1507
Glu Arg Leu Lys Gly Ile Lys Val Glu Asp Thr Asp Glu Asn Thr Leu
455 460 465
gca cgt ctg ctc ctc atc gag ctg ctg tct tgg cag ttc gca tcc cct 1555
Ala Arg Leu Leu Leu Ile Glu Leu Leu Ser Trp Gln Phe Ala Ser Pro
470 475 480 485
gtg cgt tgg atc gaa acc cag gct ctg atc atc gat acc gtc gat cag 1603
Val Arg Trp Ile Glu Thr Gln Ala Leu Ile Ile Asp Thr Val Asp Gln
490 495 500
atc atc gag gtc ggc ttg gca gca tcg cca acc ctg acc aac ctg gca 1651
Ile Ile Glu Val Gly Leu Ala Ala Ser Pro Thr Leu Thr Asn Leu Ala
505 510 515
ctg cgc acc atg gat gtc att ggc aag tcc cgc cca gta ttc aac gtg 1699
Leu Arg Thr Met Asp Val Ile Gly Lys Ser Arg Pro Val Phe Asn Val
520 525 530
gag cgc gac cag gac acc gtt atg ctc aac gat gtt cgc cag gca cct 1747
Glu Arg Asp Gln Asp Thr Val Met Leu Asn Asp Val Arg Gln Ala Pro
535 540 545
gtt gct gag gtt gaa gaa gaa gca gtt gag gaa gca cct gca gca gcc 1795
Val Ala Glu Val Glu Glu Glu Ala Val Glu Glu Ala Pro Ala Ala Ala
550 555 560 565
gca gct cca gca gct gag gca cca gtt gct gca gct cca gta gcc gca 1843
Ala Ala Pro Ala Ala Glu Ala Pro Val Ala Ala Ala Pro Val Ala Ala
570 575 580
gcc gca cct gca cct gtt gga aac gca cct gaa ctg aag ttc aac gct 1891
Ala Ala Pro Ala Pro Val Gly Asn Ala Pro Glu Leu Lys Phe Asn Ala
585 590 595
gcc aat gcc atc atg gtt ctc ttc gct gtc cag aac aag atc aac att 1939
Ala Asn Ala Ile Met Val Leu Phe Ala Val Gln Asn Lys Ile Asn Ile
600 605 610
gat cag atc acc gca gcg gat acc tct gag acc ctg acc aac ggt gtg 1987
Asp Gln Ile Thr Ala Ala Asp Thr Ser Glu Thr Leu Thr Asn Gly Val
615 620 625
tcc tca cgc cgt aac cag atg ctc atg gac atg tcc acc gag ctg tcc 2035
Ser Ser Arg Arg Asn Gln Met Leu Met Asp Met Ser Thr Glu Leu Ser
630 635 640 645
gtc cca acc atc gac ggc gca gct gac gct gac gta gct acc ctg cag 2083
Val Pro Thr Ile Asp Gly Ala Ala Asp Ala Asp Val Ala Thr Leu Gln
650 655 660
gga cgt gtt gtc acc gca gct cct ggc tac aag cct ttc gga cca gtt 2131
Gly Arg Val Val Thr Ala Ala Pro Gly Tyr Lys Pro Phe Gly Pro Val
665 670 675
ctt tcc gag acc gtt cgt gca cgt ctt cgc gca ctg acc ggt gca gca 2179
Leu Ser Glu Thr Val Arg Ala Arg Leu Arg Ala Leu Thr Gly Ala Ala
680 685 690
ggt ctg aag acc tcc tac atc ggc gat cgc gtg acc ggc acc tgg gga 2227
Gly Leu Lys Thr Ser Tyr Ile Gly Asp Arg Val Thr Gly Thr Trp Gly
695 700 705
ctt cca gaa agc tgg acc gca cac gtt gag gtt gaa ttg ctg ctg ggc 2275
Leu Pro Glu Ser Trp Thr Ala His Val Glu Val Glu Leu Leu Leu Gly
710 715 720 725
acc cgc gaa ggc gag tcc gtc cgc ggc ggc aac ctg ggt agc ctg cct 2323
Thr Arg Glu Gly Glu Ser Val Arg Gly Gly Asn Leu Gly Ser Leu Pro
730 735 740
gct aac gca tcc agc aag ggc gac gtc gat gcg ctt atc gac gca gcc 2371
Ala Asn Ala Ser Ser Lys Gly Asp Val Asp Ala Leu Ile Asp Ala Ala
745 750 755
gtg cag aat gtt gct gca gcc aac ggc acc agc gtc tcc atg tcc tcc 2419
Val Gln Asn Val Ala Ala Ala Asn Gly Thr Ser Val Ser Met Ser Ser
760 765 770
ggc ggt gca gct tca ggt ggc gga gtt gtt gat tcc gca gca ctt gat 2467
Gly Gly Ala Ala Ser Gly Gly Gly Val Val Asp Ser Ala Ala Leu Asp
775 780 785
gcc tac gca tcc acc gtc act ggt gaa gaa ggc gtc ctg gca aac gtt 2515
Ala Tyr Ala Ser Thr Val Thr Gly Glu Glu Gly Val Leu Ala Asn Val
790 795 800 805
gct cgc ggc atc ctg tct cag ctt ggt ctc gac acc aag gac gag gtt 2563
Ala Arg Gly Ile Leu Ser Gln Leu Gly Leu Asp Thr Lys Asp Glu Val
810 815 820
gaa ggc gca gag atc gac acc gaa ctc tac gac gct gtc gaa gca gaa 2611
Glu Gly Ala Glu Ile Asp Thr Glu Leu Tyr Asp Ala Val Glu Ala Glu
825 830 835
ctg ggc acc ggc tgg ctg aag ctt gtc acc cca gtg ttc tcc gct gat 2659
Leu Gly Thr Gly Trp Leu Lys Leu Val Thr Pro Val Phe Ser Ala Asp
840 845 850
cgt gcg atc ttg ttc gac gac cgt tgg gca tct gca cgt gaa gat ctg 2707
Arg Ala Ile Leu Phe Asp Asp Arg Trp Ala Ser Ala Arg Glu Asp Leu
855 860 865
gca cgc ctt gcc aac ggc gag gat att gcc gtc gag cgc ttt gct gga 2755
Ala Arg Leu Ala Asn Gly Glu Asp Ile Ala Val Glu Arg Phe Ala Gly
870 875 880 885
acg ggg gag acc gtc gtc aag caa gct gca tgg tgg gct gag cac gtt 2803
Thr Gly Glu Thr Val Val Lys Gln Ala Ala Trp Trp Ala Glu His Val
890 895 900
gaa gac acc gct ctc gct gca acc ctg aag cag gtt tcc gag gtg gct 2851
Glu Asp Thr Ala Leu Ala Ala Thr Leu Lys Gln Val Ser Glu Val Ala
905 910 915
gcg aag cca gcc aac gag cca cac atc gac gat gtt gcg ctg gtt acc 2899
Ala Lys Pro Ala Asn Glu Pro His Ile Asp Asp Val Ala Leu Val Thr
920 925 930
ggt gcg gct cct gag tcg atc gcc ggt gca gtt gcg gct cgc ctg ctg 2947
Gly Ala Ala Pro Glu Ser Ile Ala Gly Ala Val Ala Ala Arg Leu Leu
935 940 945
tcc cag ggc gcg acc gtc att ctc acc gca tcg aac gtc tcc cag gcg 2995
Ser Gln Gly Ala Thr Val Ile Leu Thr Ala Ser Asn Val Ser Gln Ala
950 955 960 965
cgt aag gaa tac gca cgc aag ctc tac gct gcg aac gca acc cct aac 3043
Arg Lys Glu Tyr Ala Arg Lys Leu Tyr Ala Ala Asn Ala Thr Pro Asn
970 975 980
gca aag ctg tgg att gtt cct gcg aac atg tcc tcc tac cgc gat gtt 3091
Ala Lys Leu Trp Ile Val Pro Ala Asn Met Ser Ser Tyr Arg Asp Val
985 990 995
gat gca gtc atc gat tgg atc ggc aac gag cag cgc gtc acc gtc ggc 3139
Asp Ala Val Ile Asp Trp Ile Gly Asn Glu Gln Arg Val Thr Val Gly
1000 1005 1010
agc acc gtc acc gtg acc aag cca gct ctg acc cca acc ctt gcg tac 3187
Ser Thr Val Thr Val Thr Lys Pro Ala Leu Thr Pro Thr Leu Ala Tyr
1015 1020 1025
cca ttc gca gct cca tcc gta tcc ggt acc ttg gcg gat gca ggc cca 3235
Pro Phe Ala Ala Pro Ser Val Ser Gly Thr Leu Ala Asp Ala Gly Pro
1030 1035 1040 1045
cag gct gaa aac cag gca cgc ctg ctc ctc tgg tcc gtg gag cgc acc 3283
Gln Ala Glu Asn Gln Ala Arg Leu Leu Leu Trp Ser Val Glu Arg Thr
1050 1055 1060
atc gca gga ctt gca gat ctt gca tcc cgc ggt gtc gat gga cgc gtc 3331
Ile Ala Gly Leu Ala Asp Leu Ala Ser Arg Gly Val Asp Gly Arg Val
1065 1070 1075
cac gtt gta ctc cca ggt tcc ccg aac cgc gga atg ttc ggt ggc gac 3379
His Val Val Leu Pro Gly Ser Pro Asn Arg Gly Met Phe Gly Gly Asp
1080 1085 1090
ggc gct tac ggc gaa gtc aag gct gct ttc gac gcc atc ctt gcc aag 3427
Gly Ala Tyr Gly Glu Val Lys Ala Ala Phe Asp Ala Ile Leu Ala Lys
1095 1100 1105
tgg ggc tcc gag acc ggc tgg cca cag ttt gtc tcc ctc gca cag gca 3475
Trp Gly Ser Glu Thr Gly Trp Pro Gln Phe Val Ser Leu Ala Gln Ala
1110 1115 1120 1125
cgc atc ggc tgg gtc gca ggc acc ggc ctc atg ggt cgc aac gac gtg 3523
Arg Ile Gly Trp Val Ala Gly Thr Gly Leu Met Gly Arg Asn Asp Val
1130 1135 1140
ctc atc cct gcc gct gaa aag ctg ggc atc cac gtc tac acc cct gaa 3571
Leu Ile Pro Ala Ala Glu Lys Leu Gly Ile His Val Tyr Thr Pro Glu
1145 1150 1155
gag atc tct tcc gaa ctg ctg ggt ctt gca tcc gca gaa tcc cgc gaa 3619
Glu Ile Ser Ser Glu Leu Leu Gly Leu Ala Ser Ala Glu Ser Arg Glu
1160 1165 1170
aag gct ctg gaa gca ccg atc gat tac gac ctg acc ggt gga ctt tcc 3667
Lys Ala Leu Glu Ala Pro Ile Asp Tyr Asp Leu Thr Gly Gly Leu Ser
1175 1180 1185
ggt ggc gta tcc atc gca gca ctg gca gca tcc ctc gag tcc gac gca 3715
Gly Gly Val Ser Ile Ala Ala Leu Ala Ala Ser Leu Glu Ser Asp Ala
1190 1195 1200 1205
gta gag acc acc tct gca gca gaa gac acc atc aag gcg ctt cca tca 3763
Val Glu Thr Thr Ser Ala Ala Glu Asp Thr Ile Lys Ala Leu Pro Ser
1210 1215 1220
cct aag cac cca gag cag cca gtg ggc acg cca gtt gga gag gtc aag 3811
Pro Lys His Pro Glu Gln Pro Val Gly Thr Pro Val Gly Glu Val Lys
1225 1230 1235
acc gat ctc gaa gac atg gtt gtc atg gtt ggc gtt ggc gaa gtc tcc 3859
Thr Asp Leu Glu Asp Met Val Val Met Val Gly Val Gly Glu Val Ser
1240 1245 1250
tca tgg ggc tcc gga cgt acc cgc ttc gaa gct gag tac ggc atc cag 3907
Ser Trp Gly Ser Gly Arg Thr Arg Phe Glu Ala Glu Tyr Gly Ile Gln
1255 1260 1265
cgc gac ggc tcc gtt gac ctc acc gca gca ggc gtc ctt gag ctt gca 3955
Arg Asp Gly Ser Val Asp Leu Thr Ala Ala Gly Val Leu Glu Leu Ala
1270 1275 1280 1285
tgg atg atg ggt ctg atc tcc tgg agc gaa gat cca aag cca gcc tgg 4003
Trp Met Met Gly Leu Ile Ser Trp Ser Glu Asp Pro Lys Pro Ala Trp
1290 1295 1300
tac gac gct gac ggc acc gaa gtg cct gaa gaa gag atc tac gag cgc 4051
Tyr Asp Ala Asp Gly Thr Glu Val Pro Glu Glu Glu Ile Tyr Glu Arg
1305 1310 1315
ttc cgc gac gaa gtc atc gca cga tgc ggt gtt cgt gag ctt gtc gac 4099
Phe Arg Asp Glu Val Ile Ala Arg Cys Gly Val Arg Glu Leu Val Asp
1320 1325 1330
gac gca ttc ctc gtc gac ggc ggc tcc ctc gac gca gct gaa gtc ttc 4147
Asp Ala Phe Leu Val Asp Gly Gly Ser Leu Asp Ala Ala Glu Val Phe
1335 1340 1345
ctc gac cgc gac atc tcc ttc tcc gta acc tct gct gaa gaa gca cag 4195
Leu Asp Arg Asp Ile Ser Phe Ser Val Thr Ser Ala Glu Glu Ala Gln
1350 1355 1360 1365
gcc tac gtc gat gca gat gct tcc gtg acc gtt gaa gaa gca gac ggc 4243
Ala Tyr Val Asp Ala Asp Ala Ser Val Thr Val Glu Glu Ala Asp Gly
1370 1375 1380
gaa tgg atc gtg acc aag aag aag ggc tcc acc tcc ttc gtg cca cgc 4291
Glu Trp Ile Val Thr Lys Lys Lys Gly Ser Thr Ser Phe Val Pro Arg
1385 1390 1395
aag gca acc ctg acc cgc tcc gta gca ggc cag ctg cca acc gac ttc 4339
Lys Ala Thr Leu Thr Arg Ser Val Ala Gly Gln Leu Pro Thr Asp Phe
1400 1405 1410
gac cct gcc aag tgg ggt atc cca gcc tcc atg atc gat gca ctc gac 4387
Asp Pro Ala Lys Trp Gly Ile Pro Ala Ser Met Ile Asp Ala Leu Asp
1415 1420 1425
aac atc gca gcg tgg aac ctg gtc act gca gtc gac gcc ttc ctg tcc 4435
Asn Ile Ala Ala Trp Asn Leu Val Thr Ala Val Asp Ala Phe Leu Ser
1430 1435 1440 1445
tcc ggc ttc agc cca gca gaa ctc ctg cag tcc atc cac cca gct gac 4483
Ser Gly Phe Ser Pro Ala Glu Leu Leu Gln Ser Ile His Pro Ala Asp
1450 1455 1460
gtg tcc tcc acc cag ggc acc ggt atc ggt ggc atg cag tcc cta cgc 4531
Val Ser Ser Thr Gln Gly Thr Gly Ile Gly Gly Met Gln Ser Leu Arg
1465 1470 1475
aag ctg ttc gtc aac cgc ttc ctc ggc cag gat cgt cca tcc gac atc 4579
Lys Leu Phe Val Asn Arg Phe Leu Gly Gln Asp Arg Pro Ser Asp Ile
1480 1485 1490
ctc cag gag acc ctg cca aac gtt gtg gct gca cac acc atg cag tcc 4627
Leu Gln Glu Thr Leu Pro Asn Val Val Ala Ala His Thr Met Gln Ser
1495 1500 1505
tac gtc ggt ggc tac ggc cag atg atc cac cca gtg gca gca tgt gca 4675
Tyr Val Gly Gly Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys Ala
1510 1515 1520 1525
acc gca gct gtc tcc gtg gaa gaa ggc gtg gac aag atc cgc ctc aac 4723
Thr Ala Ala Val Ser Val Glu Glu Gly Val Asp Lys Ile Arg Leu Asn
1530 1535 1540
aag gca gat ttc gtt gtc gcc ggt ggt atc gat gac atc cag gtt gaa 4771
Lys Ala Asp Phe Val Val Ala Gly Gly Ile Asp Asp Ile Gln Val Glu
1545 1550 1555
tcc ctg acc ggc ttc ggt gac atg aac gcc acc gca gac acc cag gca 4819
Ser Leu Thr Gly Phe Gly Asp Met Asn Ala Thr Ala Asp Thr Gln Ala
1560 1565 1570
atg ctg gac aag ggc atc gac cca cgc ttc atc tcc cgc gca aac gat 4867
Met Leu Asp Lys Gly Ile Asp Pro Arg Phe Ile Ser Arg Ala Asn Asp
1575 1580 1585
cga cgt cgc gca ggc ttc ctc gaa gca gca ggt ggc ggt acc gtc ctc 4915
Arg Arg Arg Ala Gly Phe Leu Glu Ala Ala Gly Gly Gly Thr Val Leu
1590 1595 1600 1605
ctg gca cgt gca tcc gtt gct gct gaa ctg gga ctg cca gtt ctc gca 4963
Leu Ala Arg Ala Ser Val Ala Ala Glu Leu Gly Leu Pro Val Leu Ala
1610 1615 1620
gtt gtt gca cac gca cag tcc tac gcc gat ggt gct cac acc tcc atc 5011
Val Val Ala His Ala Gln Ser Tyr Ala Asp Gly Ala His Thr Ser Ile
1625 1630 1635
cca gca ccg gga ctt ggc gca ctg ggt gca gca cgt ggt ggc aag aag 5059
Pro Ala Pro Gly Leu Gly Ala Leu Gly Ala Ala Arg Gly Gly Lys Lys
1640 1645 1650
tcc gta ctt gct cgc gaa ctg aac aaa ttg ggt ctg acc cca gat gac 5107
Ser Val Leu Ala Arg Glu Leu Asn Lys Leu Gly Leu Thr Pro Asp Asp
1655 1660 1665
gtt cgc gtg gtc tcg aag cac gac acc tcc acc aac gcc aac gat cca 5155
Val Arg Val Val Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp Pro
1670 1675 1680 1685
aac gag tcc gag ctg cac aac ctg ctg tgg aag acc att gga cgc gaa 5203
Asn Glu Ser Glu Leu His Asn Leu Leu Trp Lys Thr Ile Gly Arg Glu
1690 1695 1700
gcc gac aac ccg atg ttc gtc gtc tcc cag aag tcc ctt acc gga cac 5251
Ala Asp Asn Pro Met Phe Val Val Ser Gln Lys Ser Leu Thr Gly His
1705 1710 1715
tca aag ggc ggt gca gca ctc ttc cag atc ggt gga ctt gtc tcc atc 5299
Ser Lys Gly Gly Ala Ala Leu Phe Gln Ile Gly Gly Leu Val Ser Ile
1720 1725 1730
ctg gaa acc ggc aag ctg cca cag aac gca tcc ctt gac tgc gtt gac 5347
Leu Glu Thr Gly Lys Leu Pro Gln Asn Ala Ser Leu Asp Cys Val Asp
1735 1740 1745
cca gag atg gaa gca aag ggc gag aac ttc gtc tgg ctg cgc aag cca 5395
Pro Glu Met Glu Ala Lys Gly Glu Asn Phe Val Trp Leu Arg Lys Pro
1750 1755 1760 1765
ctg gat ctc ggc gca ggc tcc att aag gcc ggc gta ctt acc tca ctg 5443
Leu Asp Leu Gly Ala Gly Ser Ile Lys Ala Gly Val Leu Thr Ser Leu
1770 1775 1780
ggc ttc ggc cac gtg gct gca gtc gtc gtg ctg gca acc agc ggc atc 5491
Gly Phe Gly His Val Ala Ala Val Val Val Leu Ala Thr Ser Gly Ile
1785 1790 1795
ttc gag cag gca atg cgc aac gca ggc ctc gac gtc gaa gca tgg cgt 5539
Phe Glu Gln Ala Met Arg Asn Ala Gly Leu Asp Val Glu Ala Trp Arg
1800 1805 1810
gca cgc gca acc cag cgc ctg cgc acc ggt gca aac cgc cta gaa gct 5587
Ala Arg Ala Thr Gln Arg Leu Arg Thr Gly Ala Asn Arg Leu Glu Ala
1815 1820 1825
ggc atg gtt ggc cga gca cca ttg ttc gag cag gtc gac gga cgt cgc 5635
Gly Met Val Gly Arg Ala Pro Leu Phe Glu Gln Val Asp Gly Arg Arg
1830 1835 1840 1845
ctg cca gag cat ggc gct cac caa gca gag atc aac ttg ctt atc gac 5683
Leu Pro Glu His Gly Ala His Gln Ala Glu Ile Asn Leu Leu Ile Asp
1850 1855 1860
gct gac gct cgc ctc ggt gct gac ggc atc tac cag ggc taaacgttag 5732
Ala Asp Ala Arg Leu Gly Ala Asp Gly Ile Tyr Gln Gly
1865 1870
atagctaaga aag 5745
<210> 46
<211> 1874
<212> PRT
<213> Corynebacterium glutamicum
<400> 46
Val Arg Ile Val Leu Thr Thr Glu Gly Glu Val Ala Ala Lys Leu Val
1 5 10 15
Thr Arg Phe Ala Ile Arg Gly Arg Ile Thr Thr Asn Glu Met Ala Ala
20 25 30
Pro Ala Asp Ser Tyr Gly Ala Arg Asp Glu Val Val Glu Ala Thr Pro
35 40 45
Arg Ser Phe Ile Arg Gln Ala Thr Val Ser Ala Pro Ala Asp Met Thr
50 55 60
Pro Phe Ala Met Val Ser Gly Asp Tyr Asn Pro Ile His Thr Ser Asp
65 70 75 80
Asn Ala Ala Lys Leu Val Gly Leu Asp Ala Ala Leu Val His Gly Met
85 90 95
Trp Leu Ser Ala Thr Ala Gln His Leu Ala Gly Leu Gly Ser Glu Val
100 105 110
Ile Gly Trp Thr Tyr Ser Met Tyr Gly Met Val Gln Leu Asn Asp Val
115 120 125
Val Asp Ile Thr Val Glu Arg Val Gly Arg Ala Gly Leu Lys Pro Ala
130 135 140
Tyr Glu Val Thr Cys Arg Ile Asp Gly Asn Val Val Ser Arg Gly Gln
145 150 155 160
Ala Leu Leu Lys Ala Pro Ser Thr Ala Tyr Val Tyr Pro Ser Gln Gly
165 170 175
Ile Gln Ala Lys Gly Met Gly Gln Gly Asp Arg Thr Ala Ser Ala Glu
180 185 190
Ala Arg Ala Val Trp Glu Arg Ala Asp Ala His Thr Arg Ala Asn Leu
195 200 205
Gly Phe Ser Ile Gln Gln Val Ile Asp Glu Asn Pro Thr Glu Leu Lys
210 215 220
Val Gly Asp Thr Thr Phe Val His Pro Ala Gly Val Leu Asn Leu Thr
225 230 235 240
Gln Phe Thr Gln Val Ala Leu Ala Val Val Ala Tyr Ala Gln Thr Glu
245 250 255
Arg Leu Lys Ala Ala Asn Ala Ile Val Asp Gly Ser Leu Tyr Ala Gly
260 265 270
His Ser Leu Gly Glu Tyr Thr Ala Leu Ala Ser Leu Gly Asn Ile Phe
275 280 285
Glu Leu Glu Gly Val Ile Asp Val Val Phe Ser Arg Gly Ser Ala Met
290 295 300
His Ser Leu Val Pro Arg Asp Glu Lys Gly Arg Ser Asn Tyr Gly Leu
305 310 315 320
Ala Ala Phe Arg Pro Asn Met Ile Asn Val Ala Ala Thr Glu Val Glu
325 330 335
Asn Trp Val Asp Arg Val Ala Glu Glu Ser Gly Glu Phe Leu Gln Ile
340 345 350
Val Asn Tyr Asn Val Asp Gly Gln Gln Tyr Ala Val Ala Gly Thr Leu
355 360 365
Ala Gly Leu Lys Ala Leu Lys Ala Ser Ala Ser Ala Asn Pro Arg Ala
370 375 380
Tyr Val Asn Ile Pro Gly Ile Asp Val Pro Phe His Ser Ser Val Leu
385 390 395 400
Arg Pro Gly Val Pro Ala Phe Ala Glu Lys Leu Asp Glu Leu Leu Pro
405 410 415
Glu Thr Ile Asp Ile Asp Ala Leu Arg Gly Arg Tyr Ile Pro Asn Leu
420 425 430
Val Ala Arg Pro Phe Glu Leu Thr Gln Ser Phe Val Asp Ala Ile Leu
435 440 445
Ala Val Val Pro Ser Glu Arg Leu Lys Gly Ile Lys Val Glu Asp Thr
450 455 460
Asp Glu Asn Thr Leu Ala Arg Leu Leu Leu Ile Glu Leu Leu Ser Trp
465 470 475 480
Gln Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gln Ala Leu Ile Ile
485 490 495
Asp Thr Val Asp Gln Ile Ile Glu Val Gly Leu Ala Ala Ser Pro Thr
500 505 510
Leu Thr Asn Leu Ala Leu Arg Thr Met Asp Val Ile Gly Lys Ser Arg
515 520 525
Pro Val Phe Asn Val Glu Arg Asp Gln Asp Thr Val Met Leu Asn Asp
530 535 540
Val Arg Gln Ala Pro Val Ala Glu Val Glu Glu Glu Ala Val Glu Glu
545 550 555 560
Ala Pro Ala Ala Ala Ala Ala Pro Ala Ala Glu Ala Pro Val Ala Ala
565 570 575
Ala Pro Val Ala Ala Ala Ala Pro Ala Pro Val Gly Asn Ala Pro Glu
580 585 590
Leu Lys Phe Asn Ala Ala Asn Ala Ile Met Val Leu Phe Ala Val Gln
595 600 605
Asn Lys Ile Asn Ile Asp Gln Ile Thr Ala Ala Asp Thr Ser Glu Thr
610 615 620
Leu Thr Asn Gly Val Ser Ser Arg Arg Asn Gln Met Leu Met Asp Met
625 630 635 640
Ser Thr Glu Leu Ser Val Pro Thr Ile Asp Gly Ala Ala Asp Ala Asp
645 650 655
Val Ala Thr Leu Gln Gly Arg Val Val Thr Ala Ala Pro Gly Tyr Lys
660 665 670
Pro Phe Gly Pro Val Leu Ser Glu Thr Val Arg Ala Arg Leu Arg Ala
675 680 685
Leu Thr Gly Ala Ala Gly Leu Lys Thr Ser Tyr Ile Gly Asp Arg Val
690 695 700
Thr Gly Thr Trp Gly Leu Pro Glu Ser Trp Thr Ala His Val Glu Val
705 710 715 720
Glu Leu Leu Leu Gly Thr Arg Glu Gly Glu Ser Val Arg Gly Gly Asn
725 730 735
Leu Gly Ser Leu Pro Ala Asn Ala Ser Ser Lys Gly Asp Val Asp Ala
740 745 750
Leu Ile Asp Ala Ala Val Gln Asn Val Ala Ala Ala Asn Gly Thr Ser
755 760 765
Val Ser Met Ser Ser Gly Gly Ala Ala Ser Gly Gly Gly Val Val Asp
770 775 780
Ser Ala Ala Leu Asp Ala Tyr Ala Ser Thr Val Thr Gly Glu Glu Gly
785 790 795 800
Val Leu Ala Asn Val Ala Arg Gly Ile Leu Ser Gln Leu Gly Leu Asp
805 810 815
Thr Lys Asp Glu Val Glu Gly Ala Glu Ile Asp Thr Glu Leu Tyr Asp
820 825 830
Ala Val Glu Ala Glu Leu Gly Thr Gly Trp Leu Lys Leu Val Thr Pro
835 840 845
Val Phe Ser Ala Asp Arg Ala Ile Leu Phe Asp Asp Arg Trp Ala Ser
850 855 860
Ala Arg Glu Asp Leu Ala Arg Leu Ala Asn Gly Glu Asp Ile Ala Val
865 870 875 880
Glu Arg Phe Ala Gly Thr Gly Glu Thr Val Val Lys Gln Ala Ala Trp
885 890 895
Trp Ala Glu His Val Glu Asp Thr Ala Leu Ala Ala Thr Leu Lys Gln
900 905 910
Val Ser Glu Val Ala Ala Lys Pro Ala Asn Glu Pro His Ile Asp Asp
915 920 925
Val Ala Leu Val Thr Gly Ala Ala Pro Glu Ser Ile Ala Gly Ala Val
930 935 940
Ala Ala Arg Leu Leu Ser Gln Gly Ala Thr Val Ile Leu Thr Ala Ser
945 950 955 960
Asn Val Ser Gln Ala Arg Lys Glu Tyr Ala Arg Lys Leu Tyr Ala Ala
965 970 975
Asn Ala Thr Pro Asn Ala Lys Leu Trp Ile Val Pro Ala Asn Met Ser
980 985 990
Ser Tyr Arg Asp Val Asp Ala Val Ile Asp Trp Ile Gly Asn Glu Gln
995 1000 1005
Arg Val Thr Val Gly Ser Thr Val Thr Val Thr Lys Pro Ala Leu Thr
1010 1015 1020
Pro Thr Leu Ala Tyr Pro Phe Ala Ala Pro Ser Val Ser Gly Thr Leu
1025 1030 1035 1040
Ala Asp Ala Gly Pro Gln Ala Glu Asn Gln Ala Arg Leu Leu Leu Trp
1045 1050 1055
Ser Val Glu Arg Thr Ile Ala Gly Leu Ala Asp Leu Ala Ser Arg Gly
1060 1065 1070
Val Asp Gly Arg Val His Val Val Leu Pro Gly Ser Pro Asn Arg Gly
1075 1080 1085
Met Phe Gly Gly Asp Gly Ala Tyr Gly Glu Val Lys Ala Ala Phe Asp
1090 1095 1100
Ala Ile Leu Ala Lys Trp Gly Ser Glu Thr Gly Trp Pro Gln Phe Val
1105 1110 1115 1120
Ser Leu Ala Gln Ala Arg Ile Gly Trp Val Ala Gly Thr Gly Leu Met
1125 1130 1135
Gly Arg Asn Asp Val Leu Ile Pro Ala Ala Glu Lys Leu Gly Ile His
1140 1145 1150
Val Tyr Thr Pro Glu Glu Ile Ser Ser Glu Leu Leu Gly Leu Ala Ser
1155 1160 1165
Ala Glu Ser Arg Glu Lys Ala Leu Glu Ala Pro Ile Asp Tyr Asp Leu
1170 1175 1180
Thr Gly Gly Leu Ser Gly Gly Val Ser Ile Ala Ala Leu Ala Ala Ser
1185 1190 1195 1200
Leu Glu Ser Asp Ala Val Glu Thr Thr Ser Ala Ala Glu Asp Thr Ile
1205 1210 1215
Lys Ala Leu Pro Ser Pro Lys His Pro Glu Gln Pro Val Gly Thr Pro
1220 1225 1230
Val Gly Glu Val Lys Thr Asp Leu Glu Asp Met Val Val Met Val Gly
1235 1240 1245
Val Gly Glu Val Ser Ser Trp Gly Ser Gly Arg Thr Arg Phe Glu Ala
1250 1255 1260
Glu Tyr Gly Ile Gln Arg Asp Gly Ser Val Asp Leu Thr Ala Ala Gly
1265 1270 1275 1280
Val Leu Glu Leu Ala Trp Met Met Gly Leu Ile Ser Trp Ser Glu Asp
1285 1290 1295
Pro Lys Pro Ala Trp Tyr Asp Ala Asp Gly Thr Glu Val Pro Glu Glu
1300 1305 1310
Glu Ile Tyr Glu Arg Phe Arg Asp Glu Val Ile Ala Arg Cys Gly Val
1315 1320 1325
Arg Glu Leu Val Asp Asp Ala Phe Leu Val Asp Gly Gly Ser Leu Asp
1330 1335 1340
Ala Ala Glu Val Phe Leu Asp Arg Asp Ile Ser Phe Ser Val Thr Ser
1345 1350 1355 1360
Ala Glu Glu Ala Gln Ala Tyr Val Asp Ala Asp Ala Ser Val Thr Val
1365 1370 1375
Glu Glu Ala Asp Gly Glu Trp Ile Val Thr Lys Lys Lys Gly Ser Thr
1380 1385 1390
Ser Phe Val Pro Arg Lys Ala Thr Leu Thr Arg Ser Val Ala Gly Gln
1395 1400 1405
Leu Pro Thr Asp Phe Asp Pro Ala Lys Trp Gly Ile Pro Ala Ser Met
1410 1415 1420
Ile Asp Ala Leu Asp Asn Ile Ala Ala Trp Asn Leu Val Thr Ala Val
1425 1430 1435 1440
Asp Ala Phe Leu Ser Ser Gly Phe Ser Pro Ala Glu Leu Leu Gln Ser
1445 1450 1455
Ile His Pro Ala Asp Val Ser Ser Thr Gln Gly Thr Gly Ile Gly Gly
1460 1465 1470
Met Gln Ser Leu Arg Lys Leu Phe Val Asn Arg Phe Leu Gly Gln Asp
1475 1480 1485
Arg Pro Ser Asp Ile Leu Gln Glu Thr Leu Pro Asn Val Val Ala Ala
1490 1495 1500
His Thr Met Gln Ser Tyr Val Gly Gly Tyr Gly Gln Met Ile His Pro
1505 1510 1515 1520
Val Ala Ala Cys Ala Thr Ala Ala Val Ser Val Glu Glu Gly Val Asp
1525 1530 1535
Lys Ile Arg Leu Asn Lys Ala Asp Phe Val Val Ala Gly Gly Ile Asp
1540 1545 1550
Asp Ile Gln Val Glu Ser Leu Thr Gly Phe Gly Asp Met Asn Ala Thr
1555 1560 1565
Ala Asp Thr Gln Ala Met Leu Asp Lys Gly Ile Asp Pro Arg Phe Ile
1570 1575 1580
Ser Arg Ala Asn Asp Arg Arg Arg Ala Gly Phe Leu Glu Ala Ala Gly
1585 1590 1595 1600
Gly Gly Thr Val Leu Leu Ala Arg Ala Ser Val Ala Ala Glu Leu Gly
1605 1610 1615
Leu Pro Val Leu Ala Val Val Ala His Ala Gln Ser Tyr Ala Asp Gly
1620 1625 1630
Ala His Thr Ser Ile Pro Ala Pro Gly Leu Gly Ala Leu Gly Ala Ala
1635 1640 1645
Arg Gly Gly Lys Lys Ser Val Leu Ala Arg Glu Leu Asn Lys Leu Gly
1650 1655 1660
Leu Thr Pro Asp Asp Val Arg Val Val Ser Lys His Asp Thr Ser Thr
1665 1670 1675 1680
Asn Ala Asn Asp Pro Asn Glu Ser Glu Leu His Asn Leu Leu Trp Lys
1685 1690 1695
Thr Ile Gly Arg Glu Ala Asp Asn Pro Met Phe Val Val Ser Gln Lys
1700 1705 1710
Ser Leu Thr Gly His Ser Lys Gly Gly Ala Ala Leu Phe Gln Ile Gly
1715 1720 1725
Gly Leu Val Ser Ile Leu Glu Thr Gly Lys Leu Pro Gln Asn Ala Ser
1730 1735 1740
Leu Asp Cys Val Asp Pro Glu Met Glu Ala Lys Gly Glu Asn Phe Val
1745 1750 1755 1760
Trp Leu Arg Lys Pro Leu Asp Leu Gly Ala Gly Ser Ile Lys Ala Gly
1765 1770 1775
Val Leu Thr Ser Leu Gly Phe Gly His Val Ala Ala Val Val Val Leu
1780 1785 1790
Ala Thr Ser Gly Ile Phe Glu Gln Ala Met Arg Asn Ala Gly Leu Asp
1795 1800 1805
Val Glu Ala Trp Arg Ala Arg Ala Thr Gln Arg Leu Arg Thr Gly Ala
1810 1815 1820
Asn Arg Leu Glu Ala Gly Met Val Gly Arg Ala Pro Leu Phe Glu Gln
1825 1830 1835 1840
Val Asp Gly Arg Arg Leu Pro Glu His Gly Ala His Gln Ala Glu Ile
1845 1850 1855
Asn Leu Leu Ile Asp Ala Asp Ala Arg Leu Gly Ala Asp Gly Ile Tyr
1860 1865 1870
Gln Gly
<210> 47
<211> 3317
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(3294)
<223> FRXA00113
<400> 47
gct tca ggt ggc gga gtt gtt gat tcc gca gca ctt gat gcc tac gca 48
Ala Ser Gly Gly Gly Val Val Asp Ser Ala Ala Leu Asp Ala Tyr Ala
1 5 10 15
tcc acc gtc act ggt gaa gaa ggc gtc ctg gca aac gtt gct cgc ggc 96
Ser Thr Val Thr Gly Glu Glu Gly Val Leu Ala Asn Val Ala Arg Gly
20 25 30
att ctg tct cag ctt ggt ctc gac acc aag gac gag gtt gaa ggc gca 144
Ile Leu Ser Gln Leu Gly Leu Asp Thr Lys Asp Glu Val Glu Gly Ala
35 40 45
gag atc gac acc gaa ctc tac gac gct gtc gaa gca gaa ctg ggc acc 192
Glu Ile Asp Thr Glu Leu Tyr Asp Ala Val Glu Ala Glu Leu Gly Thr
50 55 60
ggc tgg ctg aag ctt gtc acc cca gtg ttc tcc gct gat cgt gcg atc 240
Gly Trp Leu Lys Leu Val Thr Pro Val Phe Ser Ala Asp Arg Ala Ile
65 70 75 80
ttg ttc gac gac cgt tgg gca tct gca cgt gaa gat ctg gca cgc ctt 288
Leu Phe Asp Asp Arg Trp Ala Ser Ala Arg Glu Asp Leu Ala Arg Leu
85 90 95
gcc aac ggc gag gat att gcc gtc gag cgc ttt gct gga acg ggg gag 336
Ala Asn Gly Glu Asp Ile Ala Val Glu Arg Phe Ala Gly Thr Gly Glu
100 105 110
acc gtc gtc aag caa gct gca tgg tgg gct gag cac gtt gaa gac acc 384
Thr Val Val Lys Gln Ala Ala Trp Trp Ala Glu His Val Glu Asp Thr
115 120 125
gct ctc gct gca acc ctg aag cag gtt tcc gag gtg gct gcg aag cca 432
Ala Leu Ala Ala Thr Leu Lys Gln Val Ser Glu Val Ala Ala Lys Pro
130 135 140
gcc aac gag cca cac atc gac gat gtt gcg ctg gtt acc ggt gcg gct 480
Ala Asn Glu Pro His Ile Asp Asp Val Ala Leu Val Thr Gly Ala Ala
145 150 155 160
cct gag tcg atc gcc ggt gca gtt gcg gct cgc ctg ctg tcc cag ggc 528
Pro Glu Ser Ile Ala Gly Ala Val Ala Ala Arg Leu Leu Ser Gln Gly
165 170 175
gcg acc gtc att ctc acc gca tcg aac gtc tcc cag gcg cgt aag gaa 576
Ala Thr Val Ile Leu Thr Ala Ser Asn Val Ser Gln Ala Arg Lys Glu
180 185 190
tac gca cgc aag ctc tac gct gcg aac gca acc cct aac gca aag ctg 624
Tyr Ala Arg Lys Leu Tyr Ala Ala Asn Ala Thr Pro Asn Ala Lys Leu
195 200 205
tgg att gtt cct gcg aac atg tcc tcc tac cgc gat gtt gat gca gtc 672
Trp Ile Val Pro Ala Asn Met Ser Ser Tyr Arg Asp Val Asp Ala Val
210 215 220
atc gat tgg atc ggc aac gag cag cgc gtc acc gtc ggc agc acc gtc 720
Ile Asp Trp Ile Gly Asn Glu Gln Arg Val Thr Val Gly Ser Thr Val
225 230 235 240
acc gtg acc aag cca gct ctg acc cca acc ctt gcg tac cca ttc gca 768
Thr Val Thr Lys Pro Ala Leu Thr Pro Thr Leu Ala Tyr Pro Phe Ala
245 250 255
gct cca tcc gta tcc ggt acc ttg gcg gat gca ggc cca cag gct gaa 816
Ala Pro Ser Val Ser Gly Thr Leu Ala Asp Ala Gly Pro Gln Ala Glu
260 265 270
aac cag gca cgc ctg ctc ctc tgg tcc gtg gag cgc acc atc gca gga 864
Asn Gln Ala Arg Leu Leu Leu Trp Ser Val Glu Arg Thr Ile Ala Gly
275 280 285
ctt gca gat ctt gca tcc cgc ggt gtc gat gga cgc gtc cac gtt gta 912
Leu Ala Asp Leu Ala Ser Arg Gly Val Asp Gly Arg Val His Val Val
290 295 300
ctc cca ggt tcc ccg aac cgc gga atg ttc ggt ggc gac ggc gct tac 960
Leu Pro Gly Ser Pro Asn Arg Gly Met Phe Gly Gly Asp Gly Ala Tyr
305 310 315 320
ggc gaa gtc aag gct gct ttc gac gcc atc ctt gcc aag tgg ggc tcc 1008
Gly Glu Val Lys Ala Ala Phe Asp Ala Ile Leu Ala Lys Trp Gly Ser
325 330 335
gag acc ggc tgg cca cag ttt gtc tcc ctc gca cag gca cgc atc ggc 1056
Glu Thr Gly Trp Pro Gln Phe Val Ser Leu Ala Gln Ala Arg Ile Gly
340 345 350
tgg gtc gca ggc acc ggc ctc atg ggt cgc aac gac gtg ctc atc cct 1104
Trp Val Ala Gly Thr Gly Leu Met Gly Arg Asn Asp Val Leu Ile Pro
355 360 365
gcc gct gaa aag ctg ggc atc cac gtc tac acc cct gaa gag atc tct 1152
Ala Ala Glu Lys Leu Gly Ile His Val Tyr Thr Pro Glu Glu Ile Ser
370 375 380
tcc gaa ctg ctg ggt ctt gca tcc gca gaa tcc cgc gaa aag gct ctg 1200
Ser Glu Leu Leu Gly Leu Ala Ser Ala Glu Ser Arg Glu Lys Ala Leu
385 390 395 400
gaa gca ccg atc gat tac gac ctg acc ggt gga ctt tcc ggt ggc gta 1248
Glu Ala Pro Ile Asp Tyr Asp Leu Thr Gly Gly Leu Ser Gly Gly Val
405 410 415
tcc atc gca gca ctg gca gca tcc ctc gag tcc gac gca gta gag acc 1296
Ser Ile Ala Ala Leu Ala Ala Ser Leu Glu Ser Asp Ala Val Glu Thr
420 425 430
acc tct gca gca gaa gac acc atc aag gcg ctt cca tca cct aag cac 1344
Thr Ser Ala Ala Glu Asp Thr Ile Lys Ala Leu Pro Ser Pro Lys His
435 440 445
cca gag cag cca gtg ggc acg cca gtt gga gag gtc aag acc gat ctc 1392
Pro Glu Gln Pro Val Gly Thr Pro Val Gly Glu Val Lys Thr Asp Leu
450 455 460
gaa gac atg gtt gtc atg gtt ggc gtt ggc gaa gtc tcc tca tgg ggc 1440
Glu Asp Met Val Val Met Val Gly Val Gly Glu Val Ser Ser Trp Gly
465 470 475 480
tcc gga cgt acc cgc ttc gaa gct gag tac ggc atc cag cgc gac ggc 1488
Ser Gly Arg Thr Arg Phe Glu Ala Glu Tyr Gly Ile Gln Arg Asp Gly
485 490 495
tcc gtt gac ctc acc gca gca ggc gtc ctt gag ctt gca tgg atg atg 1536
Ser Val Asp Leu Thr Ala Ala Gly Val Leu Glu Leu Ala Trp Met Met
500 505 510
ggt ctg atc tcc tgg agc gaa gat cca aag cca gcc tgg tac gac gct 1584
Gly Leu Ile Ser Trp Ser Glu Asp Pro Lys Pro Ala Trp Tyr Asp Ala
515 520 525
gac ggc acc gaa gtg cct gaa gaa gag atc tac gag cgc ttc cgc gac 1632
Asp Gly Thr Glu Val Pro Glu Glu Glu Ile Tyr Glu Arg Phe Arg Asp
530 535 540
gaa gtc atc gca cga tgc ggt gtt cgt gag ctt gtc gac gac gca ttc 1680
Glu Val Ile Ala Arg Cys Gly Val Arg Glu Leu Val Asp Asp Ala Phe
545 550 555 560
ctc gtc gac ggc ggc tcc ctc gac gca gct gaa gtc ttc ctc gac cgc 1728
Leu Val Asp Gly Gly Ser Leu Asp Ala Ala Glu Val Phe Leu Asp Arg
565 570 575
gac atc tcc ttc tcc gta acc tct gct gaa gaa gca cag gcc tac gtc 1776
Asp Ile Ser Phe Ser Val Thr Ser Ala Glu Glu Ala Gln Ala Tyr Val
580 585 590
gat gca gat gct tcc gtg acc gtt gaa gaa gca gac ggc gaa tgg atc 1824
Asp Ala Asp Ala Ser Val Thr Val Glu Glu Ala Asp Gly Glu Trp Ile
595 600 605
gtg acc aag aag aag ggc tcc acc tcc ttc gtg cca cgc aag gca acc 1872
Val Thr Lys Lys Lys Gly Ser Thr Ser Phe Val Pro Arg Lys Ala Thr
610 615 620
ctg acc cgc tcc gta gca ggc cag ctg cca acc gac ttc gac cct gcc 1920
Leu Thr Arg Ser Val Ala Gly Gln Leu Pro Thr Asp Phe Asp Pro Ala
625 630 635 640
aag tgg ggt atc cca gcc tcc atg atc gat gca ctc gac aac atc gca 1968
Lys Trp Gly Ile Pro Ala Ser Met Ile Asp Ala Leu Asp Asn Ile Ala
645 650 655
gcg tgg aac ctg gtc act gca gtc gac gcc ttc ctg tcc tcc ggc ttc 2016
Ala Trp Asn Leu Val Thr Ala Val Asp Ala Phe Leu Ser Ser Gly Phe
660 665 670
agc cca gca gaa ctc ctg cag tcc atc cac cca gct gac gtg tcc tcc 2064
Ser Pro Ala Glu Leu Leu Gln Ser Ile His Pro Ala Asp Val Ser Ser
675 680 685
acc cag ggc acc ggt atc ggt ggc atg cag tcc cta cgc aag ctg ttc 2112
Thr Gln Gly Thr Gly Ile Gly Gly Met Gln Ser Leu Arg Lys Leu Phe
690 695 700
gtc aac cgc ttc ctc ggc cag gat cgt cca tcc gac atc ctc cag gag 2160
Val Asn Arg Phe Leu Gly Gln Asp Arg Pro Ser Asp Ile Leu Gln Glu
705 710 715 720
acc ctg cca aac gtt gtg gct gca cac acc atg cag tcc tac gtc ggt 2208
Thr Leu Pro Asn Val Val Ala Ala His Thr Met Gln Ser Tyr Val Gly
725 730 735
ggc tac ggc cag atg atc cac cca gtg gca gca tgt gca acc gca gct 2256
Gly Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys Ala Thr Ala Ala
740 745 750
gtc tcc gtg gaa gaa ggc gtg gac aag atc cgc ctc aac aag gca gat 2304
Val Ser Val Glu Glu Gly Val Asp Lys Ile Arg Leu Asn Lys Ala Asp
755 760 765
ttc gtt gtc gcc ggt ggt atc gat gac atc cag gtt gaa tcc ctg acc 2352
Phe Val Val Ala Gly Gly Ile Asp Asp Ile Gln Val Glu Ser Leu Thr
770 775 780
ggc ttc ggt gac atg aac gcc acc gca gac acc cag gca atg ctg gac 2400
Gly Phe Gly Asp Met Asn Ala Thr Ala Asp Thr Gln Ala Met Leu Asp
785 790 795 800
aag ggc atc gac cca cgc ttc atc tcc cgc gca aac gat cga cgt cgc 2448
Lys Gly Ile Asp Pro Arg Phe Ile Ser Arg Ala Asn Asp Arg Arg Arg
805 810 815
gca ggc ttc ctc gaa gca gca ggt ggc ggt acc gtc ctc ctg gca cgt 2496
Ala Gly Phe Leu Glu Ala Ala Gly Gly Gly Thr Val Leu Leu Ala Arg
820 825 830
gca tcc gtt gct gct gaa ctg gga ctg cca gtt ctc gca gtt gtt gca 2544
Ala Ser Val Ala Ala Glu Leu Gly Leu Pro Val Leu Ala Val Val Ala
835 840 845
cac gca cag tcc tac gcc gat ggt gct cac acc tcc atc cca gca ccg 2592
His Ala Gln Ser Tyr Ala Asp Gly Ala His Thr Ser Ile Pro Ala Pro
850 855 860
gga ctt ggc gca ctg ggt gca gca cgt ggt ggc aag aag tcc gta ctt 2640
Gly Leu Gly Ala Leu Gly Ala Ala Arg Gly Gly Lys Lys Ser Val Leu
865 870 875 880
gct cgc gaa ctg aac aaa ttg ggt ctg acc cca gat gac gtt cgc gtg 2688
Ala Arg Glu Leu Asn Lys Leu Gly Leu Thr Pro Asp Asp Val Arg Val
885 890 895
gtc tcg aag cac gac acc tcc acc aac gcc aac gat cca aac gag tcc 2736
Val Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp Pro Asn Glu Ser
900 905 910
gag ctg cac aac ctg ctg tgg aag acc att gga cgc gaa gcc gac aac 2784
Glu Leu His Asn Leu Leu Trp Lys Thr Ile Gly Arg Glu Ala Asp Asn
915 920 925
ccg atg ttc gtc gtc tcc cag aag tcc ctt acc gga cac tca aag ggc 2832
Pro Met Phe Val Val Ser Gln Lys Ser Leu Thr Gly His Ser Lys Gly
930 935 940
ggt gca gca ctc ttc cag atc ggt gga ctt gtc tcc atc ctg gaa acc 2880
Gly Ala Ala Leu Phe Gln Ile Gly Gly Leu Val Ser Ile Leu Glu Thr
945 950 955 960
ggc aag ctg cca cag aac gca tcc ctt gac tgc gtt gac cca gag atg 2928
Gly Lys Leu Pro Gln Asn Ala Ser Leu Asp Cys Val Asp Pro Glu Met
965 970 975
gaa gca aag ggc gag aac ttc gtc tgg ctg cgc aag cca ctg gat ctc 2976
Glu Ala Lys Gly Glu Asn Phe Val Trp Leu Arg Lys Pro Leu Asp Leu
980 985 990
ggc gca ggc tcc att aag gcc ggc gta ctt acc tca ctg ggc ttc ggc 3024
Gly Ala Gly Ser Ile Lys Ala Gly Val Leu Thr Ser Leu Gly Phe Gly
995 1000 1005
cac gtg gct gca gtc gtc gtg ctg gca acc agc ggc atc ttc gag cag 3072
His Val Ala Ala Val Val Val Leu Ala Thr Ser Gly Ile Phe Glu Gln
1010 1015 1020
gca atg cgc aac gca ggc ctc gac gtc gaa gca tgg cgt gca cgc gca 3120
Ala Met Arg Asn Ala Gly Leu Asp Val Glu Ala Trp Arg Ala Arg Ala
1025 1030 1035 1040
acc cag cgc ctg cgc acc ggt gca aac cgc cta gaa gct ggc atg gtt 3168
Thr Gln Arg Leu Arg Thr Gly Ala Asn Arg Leu Glu Ala Gly Met Val
1045 1050 1055
ggc cga gca cca ttg ttc gag cag gtc gac gga cgt cgc ctg cca gag 3216
Gly Arg Ala Pro Leu Phe Glu Gln Val Asp Gly Arg Arg Leu Pro Glu
1060 1065 1070
cat ggc gct cac caa gca gag atc aac ttg ctt atc gac gct gac gct 3264
His Gly Ala His Gln Ala Glu Ile Asn Leu Leu Ile Asp Ala Asp Ala
1075 1080 1085
cgc ctc ggt gct gac ggc atc tac cag ggc taaacgttag atagctaaga 3314
Arg Leu Gly Ala Asp Gly Ile Tyr Gln Gly
1090 1095
aag 3317
<210> 48
<211> 1098
<212> PRT
<213> Corynebacterium glutamicum
<400> 48
Ala Ser Gly Gly Gly Val Val Asp Ser Ala Ala Leu Asp Ala Tyr Ala
1 5 10 15
Ser Thr Val Thr Gly Glu Glu Gly Val Leu Ala Asn Val Ala Arg Gly
20 25 30
Ile Leu Ser Gln Leu Gly Leu Asp Thr Lys Asp Glu Val Glu Gly Ala
35 40 45
Glu Ile Asp Thr Glu Leu Tyr Asp Ala Val Glu Ala Glu Leu Gly Thr
50 55 60
Gly Trp Leu Lys Leu Val Thr Pro Val Phe Ser Ala Asp Arg Ala Ile
65 70 75 80
Leu Phe Asp Asp Arg Trp Ala Ser Ala Arg Glu Asp Leu Ala Arg Leu
85 90 95
Ala Asn Gly Glu Asp Ile Ala Val Glu Arg Phe Ala Gly Thr Gly Glu
100 105 110
Thr Val Val Lys Gln Ala Ala Trp Trp Ala Glu His Val Glu Asp Thr
115 120 125
Ala Leu Ala Ala Thr Leu Lys Gln Val Ser Glu Val Ala Ala Lys Pro
130 135 140
Ala Asn Glu Pro His Ile Asp Asp Val Ala Leu Val Thr Gly Ala Ala
145 150 155 160
Pro Glu Ser Ile Ala Gly Ala Val Ala Ala Arg Leu Leu Ser Gln Gly
165 170 175
Ala Thr Val Ile Leu Thr Ala Ser Asn Val Ser Gln Ala Arg Lys Glu
180 185 190
Tyr Ala Arg Lys Leu Tyr Ala Ala Asn Ala Thr Pro Asn Ala Lys Leu
195 200 205
Trp Ile Val Pro Ala Asn Met Ser Ser Tyr Arg Asp Val Asp Ala Val
210 215 220
Ile Asp Trp Ile Gly Asn Glu Gln Arg Val Thr Val Gly Ser Thr Val
225 230 235 240
Thr Val Thr Lys Pro Ala Leu Thr Pro Thr Leu Ala Tyr Pro Phe Ala
245 250 255
Ala Pro Ser Val Ser Gly Thr Leu Ala Asp Ala Gly Pro Gln Ala Glu
260 265 270
Asn Gln Ala Arg Leu Leu Leu Trp Ser Val Glu Arg Thr Ile Ala Gly
275 280 285
Leu Ala Asp Leu Ala Ser Arg Gly Val Asp Gly Arg Val His Val Val
290 295 300
Leu Pro Gly Ser Pro Asn Arg Gly Met Phe Gly Gly Asp Gly Ala Tyr
305 310 315 320
Gly Glu Val Lys Ala Ala Phe Asp Ala Ile Leu Ala Lys Trp Gly Ser
325 330 335
Glu Thr Gly Trp Pro Gln Phe Val Ser Leu Ala Gln Ala Arg Ile Gly
340 345 350
Trp Val Ala Gly Thr Gly Leu Met Gly Arg Asn Asp Val Leu Ile Pro
355 360 365
Ala Ala Glu Lys Leu Gly Ile His Val Tyr Thr Pro Glu Glu Ile Ser
370 375 380
Ser Glu Leu Leu Gly Leu Ala Ser Ala Glu Ser Arg Glu Lys Ala Leu
385 390 395 400
Glu Ala Pro Ile Asp Tyr Asp Leu Thr Gly Gly Leu Ser Gly Gly Val
405 410 415
Ser Ile Ala Ala Leu Ala Ala Ser Leu Glu Ser Asp Ala Val Glu Thr
420 425 430
Thr Ser Ala Ala Glu Asp Thr Ile Lys Ala Leu Pro Ser Pro Lys His
435 440 445
Pro Glu Gln Pro Val Gly Thr Pro Val Gly Glu Val Lys Thr Asp Leu
450 455 460
Glu Asp Met Val Val Met Val Gly Val Gly Glu Val Ser Ser Trp Gly
465 470 475 480
Ser Gly Arg Thr Arg Phe Glu Ala Glu Tyr Gly Ile Gln Arg Asp Gly
485 490 495
Ser Val Asp Leu Thr Ala Ala Gly Val Leu Glu Leu Ala Trp Met Met
500 505 510
Gly Leu Ile Ser Trp Ser Glu Asp Pro Lys Pro Ala Trp Tyr Asp Ala
515 520 525
Asp Gly Thr Glu Val Pro Glu Glu Glu Ile Tyr Glu Arg Phe Arg Asp
530 535 540
Glu Val Ile Ala Arg Cys Gly Val Arg Glu Leu Val Asp Asp Ala Phe
545 550 555 560
Leu Val Asp Gly Gly Ser Leu Asp Ala Ala Glu Val Phe Leu Asp Arg
565 570 575
Asp Ile Ser Phe Ser Val Thr Ser Ala Glu Glu Ala Gln Ala Tyr Val
580 585 590
Asp Ala Asp Ala Ser Val Thr Val Glu Glu Ala Asp Gly Glu Trp Ile
595 600 605
Val Thr Lys Lys Lys Gly Ser Thr Ser Phe Val Pro Arg Lys Ala Thr
610 615 620
Leu Thr Arg Ser Val Ala Gly Gln Leu Pro Thr Asp Phe Asp Pro Ala
625 630 635 640
Lys Trp Gly Ile Pro Ala Ser Met Ile Asp Ala Leu Asp Asn Ile Ala
645 650 655
Ala Trp Asn Leu Val Thr Ala Val Asp Ala Phe Leu Ser Ser Gly Phe
660 665 670
Ser Pro Ala Glu Leu Leu Gln Ser Ile His Pro Ala Asp Val Ser Ser
675 680 685
Thr Gln Gly Thr Gly Ile Gly Gly Met Gln Ser Leu Arg Lys Leu Phe
690 695 700
Val Asn Arg Phe Leu Gly Gln Asp Arg Pro Ser Asp Ile Leu Gln Glu
705 710 715 720
Thr Leu Pro Asn Val Val Ala Ala His Thr Met Gln Ser Tyr Val Gly
725 730 735
Gly Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys Ala Thr Ala Ala
740 745 750
Val Ser Val Glu Glu Gly Val Asp Lys Ile Arg Leu Asn Lys Ala Asp
755 760 765
Phe Val Val Ala Gly Gly Ile Asp Asp Ile Gln Val Glu Ser Leu Thr
770 775 780
Gly Phe Gly Asp Met Asn Ala Thr Ala Asp Thr Gln Ala Met Leu Asp
785 790 795 800
Lys Gly Ile Asp Pro Arg Phe Ile Ser Arg Ala Asn Asp Arg Arg Arg
805 810 815
Ala Gly Phe Leu Glu Ala Ala Gly Gly Gly Thr Val Leu Leu Ala Arg
820 825 830
Ala Ser Val Ala Ala Glu Leu Gly Leu Pro Val Leu Ala Val Val Ala
835 840 845
His Ala Gln Ser Tyr Ala Asp Gly Ala His Thr Ser Ile Pro Ala Pro
850 855 860
Gly Leu Gly Ala Leu Gly Ala Ala Arg Gly Gly Lys Lys Ser Val Leu
865 870 875 880
Ala Arg Glu Leu Asn Lys Leu Gly Leu Thr Pro Asp Asp Val Arg Val
885 890 895
Val Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp Pro Asn Glu Ser
900 905 910
Glu Leu His Asn Leu Leu Trp Lys Thr Ile Gly Arg Glu Ala Asp Asn
915 920 925
Pro Met Phe Val Val Ser Gln Lys Ser Leu Thr Gly His Ser Lys Gly
930 935 940
Gly Ala Ala Leu Phe Gln Ile Gly Gly Leu Val Ser Ile Leu Glu Thr
945 950 955 960
Gly Lys Leu Pro Gln Asn Ala Ser Leu Asp Cys Val Asp Pro Glu Met
965 970 975
Glu Ala Lys Gly Glu Asn Phe Val Trp Leu Arg Lys Pro Leu Asp Leu
980 985 990
Gly Ala Gly Ser Ile Lys Ala Gly Val Leu Thr Ser Leu Gly Phe Gly
995 1000 1005
His Val Ala Ala Val Val Val Leu Ala Thr Ser Gly Ile Phe Glu Gln
1010 1015 1020
Ala Met Arg Asn Ala Gly Leu Asp Val Glu Ala Trp Arg Ala Arg Ala
1025 1030 1035 1040
Thr Gln Arg Leu Arg Thr Gly Ala Asn Arg Leu Glu Ala Gly Met Val
1045 1050 1055
Gly Arg Ala Pro Leu Phe Glu Gln Val Asp Gly Arg Arg Leu Pro Glu
1060 1065 1070
His Gly Ala His Gln Ala Glu Ile Asn Leu Leu Ile Asp Ala Asp Ala
1075 1080 1085
Arg Leu Gly Ala Asp Gly Ile Tyr Gln Gly
1090 1095
<210> 49
<211> 6136
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(6136)
<223> RXN03111
<400> 49
cgtgaccgaa ttgagcagga acttcggggc cagccgactg attaaccgct ttggccagga 60
gccttttgcc ttcgctttcg ccggccaagg atatgactgg ttg aag acc ctt cgt 115
Leu Lys Thr Leu Arg
1 5
gcc gcg gtt gcc gca ggt gca ggc acc aat gtt agt gac atc gtc gag 163
Ala Ala Val Ala Ala Gly Ala Gly Thr Asn Val Ser Asp Ile Val Glu
10 15 20
cgc gca aat gcg ctg ctt gca cta gtt gca gat gat ctc att ggc acc 211
Arg Ala Asn Ala Leu Leu Ala Leu Val Ala Asp Asp Leu Ile Gly Thr
25 30 35
ctt cca ttt ggt ttc gat cca gtg gct tgg gct aac aac tcc gaa gat 259
Leu Pro Phe Gly Phe Asp Pro Val Ala Trp Ala Asn Asn Ser Glu Asp
40 45 50
cca gct ttc gat act gca caa tct gca gtg agc gtg ccg ggt atc ttt 307
Pro Ala Phe Asp Thr Ala Gln Ser Ala Val Ser Val Pro Gly Ile Phe
55 60 65
gtc tcc cag atc gca acc ctg gat tcc ctt gag gcg cag cgc ctt gat 355
Val Ser Gln Ile Ala Thr Leu Asp Ser Leu Glu Ala Gln Arg Leu Asp
70 75 80 85
gtg gat cag gct gtg tcc agc att ggt cat tcc cag ggc gta ttg ggc 403
Val Asp Gln Ala Val Ser Ser Ile Gly His Ser Gln Gly Val Leu Gly
90 95 100
gtg cac ctg ctc aat gat gcg act cgt gct gat gaa ctc gtt gcc att 451
Val His Leu Leu Asn Asp Ala Thr Arg Ala Asp Glu Leu Val Ala Ile
105 110 115
gcg cag ttg atc ggt gca gcg atc acc cgc acc gca cgc atg acg ggc 499
Ala Gln Leu Ile Gly Ala Ala Ile Thr Arg Thr Ala Arg Met Thr Gly
120 125 130
ctg atc gcg cag ggc gac aac atg ccg atg ctg tcg atc gcc gga att 547
Leu Ile Ala Gln Gly Asp Asn Met Pro Met Leu Ser Ile Ala Gly Ile
135 140 145
tcc cgc gaa cag ctt cag caa gct atc gac gcg gcc tgc gcc gaa gtc 595
Ser Arg Glu Gln Leu Gln Gln Ala Ile Asp Ala Ala Cys Ala Glu Val
150 155 160 165
cct gcg gag atc cgc ccg gtt atc ggt ctg cgc aac tca cgc gat tct 643
Pro Ala Glu Ile Arg Pro Val Ile Gly Leu Arg Asn Ser Arg Asp Ser
170 175 180
tat gtt ttg gtt ggc cgc cca gac gac aac gct cgc gtt gtt aag gtc 691
Tyr Val Leu Val Gly Arg Pro Asp Asp Asn Ala Arg Val Val Lys Val
185 190 195
att gag gca atg gct gcc aag gat aag aag gcc att gaa gat aag ctg 739
Ile Glu Ala Met Ala Ala Lys Asp Lys Lys Ala Ile Glu Asp Lys Leu
200 205 210
cgc ggc ggt tcc gcg ttc agc ccc cgt att act ccg ctg aag gtg cag 787
Arg Gly Gly Ser Ala Phe Ser Pro Arg Ile Thr Pro Leu Lys Val Gln
215 220 225
gct gct ttc cat cac cca gct atg aac atg gct gtg gag cag acc gtg 835
Ala Ala Phe His His Pro Ala Met Asn Met Ala Val Glu Gln Thr Val
230 235 240 245
gcg tgg gca acc act gct ggt ttg gat gtg gaa ctc acc cgc gag atc 883
Ala Trp Ala Thr Thr Ala Gly Leu Asp Val Glu Leu Thr Arg Glu Ile
250 255 260
gcc gct gat gtt ttg gtt aac cct gtc gat tgg gta gca cgc gtc aac 931
Ala Ala Asp Val Leu Val Asn Pro Val Asp Trp Val Ala Arg Val Asn
265 270 275
gaa gcg tat gag gct ggc gct cgc tgg ttc ctc gac gtt gga cca gat 979
Glu Ala Tyr Glu Ala Gly Ala Arg Trp Phe Leu Asp Val Gly Pro Asp
280 285 290
ggt ggc atc gtt aag ctg act gcc aac atc ctt gag ggc cgc ggc gcg 1027
Gly Gly Ile Val Lys Leu Thr Ala Asn Ile Leu Glu Gly Arg Gly Ala
295 300 305
gat tcc ttc tat gtt ggt gac gcc gca ggc cag gcc aag ata ttt gat 1075
Asp Ser Phe Tyr Val Gly Asp Ala Ala Gly Gln Ala Lys Ile Phe Asp
310 315 320 325
gct ggc atg gca cct gaa ctt cca gtg gat tac cag gag ttc gca cca 1123
Ala Gly Met Ala Pro Glu Leu Pro Val Asp Tyr Gln Glu Phe Ala Pro
330 335 340
cgc gtt gag cac gtt gat gga acc cca cgc ctg gtt acc aag ttc act 1171
Arg Val Glu His Val Asp Gly Thr Pro Arg Leu Val Thr Lys Phe Thr
345 350 355
gag ctg acc ggc cgc acc cca atg atg ctg gct ggc atg acc cca acc 1219
Glu Leu Thr Gly Arg Thr Pro Met Met Leu Ala Gly Met Thr Pro Thr
360 365 370
acc gtt gac cct gcc att gtt gca gcc gct gca aac ggt gga cac tgg 1267
Thr Val Asp Pro Ala Ile Val Ala Ala Ala Ala Asn Gly Gly His Trp
375 380 385
gct gag ctc gct ggt ggc gga cag gtt acc cca gag ctg ctg gaa acc 1315
Ala Glu Leu Ala Gly Gly Gly Gln Val Thr Pro Glu Leu Leu Glu Thr
390 395 400 405
cac atc gca cag ctc acc gac atg ctt gag cca ggt atc aac gcc cag 1363
His Ile Ala Gln Leu Thr Asp Met Leu Glu Pro Gly Ile Asn Ala Gln
410 415 420
ttc aac tcc atg ttc ttg gat cca tac ctg tgg aag atg cag att ggt 1411
Phe Asn Ser Met Phe Leu Asp Pro Tyr Leu Trp Lys Met Gln Ile Gly
425 430 435
ggc aag cgc ctt gtt cct aag gcc cgc gct aat ggt gca tcc atc gac 1459
Gly Lys Arg Leu Val Pro Lys Ala Arg Ala Asn Gly Ala Ser Ile Asp
440 445 450
ggc atc gtc atc acc gcc ggc att cct gaa aag gat gaa gct gtt gca 1507
Gly Ile Val Ile Thr Ala Gly Ile Pro Glu Lys Asp Glu Ala Val Ala
455 460 465
ttg gtc aag gaa ctg atg cgt gat ggt ttc cct tgg atc gca ttc aag 1555
Leu Val Lys Glu Leu Met Arg Asp Gly Phe Pro Trp Ile Ala Phe Lys
470 475 480 485
cca ggt gcc atc aag cag gtt aac tct gtg ttg gct atc gct aag gaa 1603
Pro Gly Ala Ile Lys Gln Val Asn Ser Val Leu Ala Ile Ala Lys Glu
490 495 500
gtt cca gaa ctc ccc atc atc att cag att gag ggt ggc gtt gca ggt 1651
Val Pro Glu Leu Pro Ile Ile Ile Gln Ile Glu Gly Gly Val Ala Gly
505 510 515
gga cac cac tct tgg gaa gac ctc gat gag ctg ctg atc gcc acc tac 1699
Gly His His Ser Trp Glu Asp Leu Asp Glu Leu Leu Ile Ala Thr Tyr
520 525 530
ggc aag gtc cgc gca ctg gat aac gtg gtg ctg tgt gtc ggc ggt ggc 1747
Gly Lys Val Arg Ala Leu Asp Asn Val Val Leu Cys Val Gly Gly Gly
535 540 545
att ggc tca cct gag cgc gct gct gat tac gtc acc ggt tcc tgg tcc 1795
Ile Gly Ser Pro Glu Arg Ala Ala Asp Tyr Val Thr Gly Ser Trp Ser
550 555 560 565
act tcc tac ggc ctg cca gct atg cct gtt gat ggc atc ttg gtg ggt 1843
Thr Ser Tyr Gly Leu Pro Ala Met Pro Val Asp Gly Ile Leu Val Gly
570 575 580
acc gct gcg atg gca acc aag gaa gca acc acc tcc cag gcc gtc aag 1891
Thr Ala Ala Met Ala Thr Lys Glu Ala Thr Thr Ser Gln Ala Val Lys
585 590 595
gaa ctt ctt gtt tcc acc cag ggc tct gat gaa tgg gtt cct gct ggt 1939
Glu Leu Leu Val Ser Thr Gln Gly Ser Asp Glu Trp Val Pro Ala Gly
600 605 610
ggc gca aag aac gga atg gca tct ggc cgt tcc cag ctt ggc gca gac 1987
Gly Ala Lys Asn Gly Met Ala Ser Gly Arg Ser Gln Leu Gly Ala Asp
615 620 625
atc cac gag atc gac aac tcc ttt gct aag gct gga cgc ctt ctt gat 2035
Ile His Glu Ile Asp Asn Ser Phe Ala Lys Ala Gly Arg Leu Leu Asp
630 635 640 645
gag gtt gca ggc gat gag acg gct gtg cag gcg cgc cgg gat gag atc 2083
Glu Val Ala Gly Asp Glu Thr Ala Val Gln Ala Arg Arg Asp Glu Ile
650 655 660
att gaa gcg att ggc aag acc gcc aag gtg tac ttc ggt gac atc gga 2131
Ile Glu Ala Ile Gly Lys Thr Ala Lys Val Tyr Phe Gly Asp Ile Gly
665 670 675
tcc atg act tac gag cag tgg ctc aac cgc tac ctc gag ctg tct ggc 2179
Ser Met Thr Tyr Glu Gln Trp Leu Asn Arg Tyr Leu Glu Leu Ser Gly
680 685 690
cct gtt gat ggt cag tgg att gat gct tcc tgg gct gca cgt ttt gcc 2227
Pro Val Asp Gly Gln Trp Ile Asp Ala Ser Trp Ala Ala Arg Phe Ala
695 700 705
cag atg ctg gag cgt gcc gag gcg cgt ttg atc gag cag gat cat ggc 2275
Gln Met Leu Glu Arg Ala Glu Ala Arg Leu Ile Glu Gln Asp His Gly
710 715 720 725
caa ttt gag cca agc ctg acg gtg gag gat ggc gtc gac aag ctt gtt 2323
Gln Phe Glu Pro Ser Leu Thr Val Glu Asp Gly Val Asp Lys Leu Val
730 735 740
gct gct tac ccg cat gcc gca acc gac ctg ctc acc ccg gct gat gtc 2371
Ala Ala Tyr Pro His Ala Ala Thr Asp Leu Leu Thr Pro Ala Asp Val
745 750 755
gcc tgg ttc ttg ggc ctg tgc cgc acg ccg ggc aag cct gtg aac ttt 2419
Ala Trp Phe Leu Gly Leu Cys Arg Thr Pro Gly Lys Pro Val Asn Phe
760 765 770
gtg ccc gtc att gat aag gac gtg cgt cgc tgg tgg cgc tcg gac tcc 2467
Val Pro Val Ile Asp Lys Asp Val Arg Arg Trp Trp Arg Ser Asp Ser
775 780 785
ctg tgg cag tcc cac gat gat cgc tac acc gct gat cag gtg gct att 2515
Leu Trp Gln Ser His Asp Asp Arg Tyr Thr Ala Asp Gln Val Ala Ile
790 795 800 805
atc cct ggt gtc gtc gcc gtt gct ggc atc acc aag gcc aac gaa cct 2563
Ile Pro Gly Val Val Ala Val Ala Gly Ile Thr Lys Ala Asn Glu Pro
810 815 820
gtc gct gac ctg ctt gat cgc ttt gtc gac gcc acc atc gag cgc atc 2611
Val Ala Asp Leu Leu Asp Arg Phe Val Asp Ala Thr Ile Glu Arg Ile
825 830 835
gat gag cac gat tcc cgc tcc cgc gac atc atg ggc aaa gtg ctt tcc 2659
Asp Glu His Asp Ser Arg Ser Arg Asp Ile Met Gly Lys Val Leu Ser
840 845 850
tca cct ggc aca ttc tgg gct ggc cgc aac atc cca tcg gtg atc cac 2707
Ser Pro Gly Thr Phe Trp Ala Gly Arg Asn Ile Pro Ser Val Ile His
855 860 865
agc ctt ggg cat gct gac aag tgg tcc cgc tcc gaa ttc gaa gca ttc 2755
Ser Leu Gly His Ala Asp Lys Trp Ser Arg Ser Glu Phe Glu Ala Phe
870 875 880 885
cat agc cca acc ggc gcc aac ttg gtg tac gaa gac gcc gag cac gcg 2803
His Ser Pro Thr Gly Ala Asn Leu Val Tyr Glu Asp Ala Glu His Ala
890 895 900
atg ctg act gtg cct ttg gcg ggt tcc acc gca ttc ggc acc acc gct 2851
Met Leu Thr Val Pro Leu Ala Gly Ser Thr Ala Phe Gly Thr Thr Ala
905 910 915
gag ctg aaa atc cgt ttc acc agc ccc atc gac gct ctg cca agc gct 2899
Glu Leu Lys Ile Arg Phe Thr Ser Pro Ile Asp Ala Leu Pro Ser Ala
920 925 930
gtc cca ctg gtc acc cag gaa gac gct gaa gcc gcg atg ggt gaa ctg 2947
Val Pro Leu Val Thr Gln Glu Asp Ala Glu Ala Ala Met Gly Glu Leu
935 940 945
acc cgc atc gca gct ggc ggc acc ctg gca act gtg aac aat ggc acc 2995
Thr Arg Ile Ala Ala Gly Gly Thr Leu Ala Thr Val Asn Asn Gly Thr
950 955 960 965
gct acc tgg gaa acc tcc gtc gat gcc ggc gtc atc gct gac tac aac 3043
Ala Thr Trp Glu Thr Ser Val Asp Ala Gly Val Ile Ala Asp Tyr Asn
970 975 980
aac gtc acc gca ggc tac ctg cca gca tcc gtt gtt cct gca cac acc 3091
Asn Val Thr Ala Gly Tyr Leu Pro Ala Ser Val Val Pro Ala His Thr
985 990 995
gca cct gac gtg ctg gtt ggc cgc gca tgg cca gca gtt ttc gct gcc 3139
Ala Pro Asp Val Leu Val Gly Arg Ala Trp Pro Ala Val Phe Ala Ala
1000 1005 1010
gta aag tcc gca gtc atc cca ggc acc gat tcc gca tcc gtt gtg gaa 3187
Val Lys Ser Ala Val Ile Pro Gly Thr Asp Ser Ala Ser Val Val Glu
1015 1020 1025
ggc atg ctg tcc ctg gtt cac ctg gag cac cac att gtg ctc aag tcc 3235
Gly Met Leu Ser Leu Val His Leu Glu His His Ile Val Leu Lys Ser
1030 1035 1040 1045
gat gtc cca acc gac ggc gcg ctg aag gtt tcc gcg act gcc gat gag 3283
Asp Val Pro Thr Asp Gly Ala Leu Lys Val Ser Ala Thr Ala Asp Glu
1050 1055 1060
gta gtc gat acc gac ctg ggt cgc ctc gtg atc gtg cgc gca gaa atc 3331
Val Val Asp Thr Asp Leu Gly Arg Leu Val Ile Val Arg Ala Glu Ile
1065 1070 1075
gcc gac gca gaa ggc aac ctg att gct acg ttg gct gag cgt ttc gcg 3379
Ala Asp Ala Glu Gly Asn Leu Ile Ala Thr Leu Ala Glu Arg Phe Ala
1080 1085 1090
atc cgc gga cgc aag ggc aac gct gtc gca cgc acc aac acc tcc gca 3427
Ile Arg Gly Arg Lys Gly Asn Ala Val Ala Arg Thr Asn Thr Ser Ala
1095 1100 1105
ctg cca acc acc gtg gac acc cca cgc tca gct cgc gca gtg gca acc 3475
Leu Pro Thr Thr Val Asp Thr Pro Arg Ser Ala Arg Ala Val Ala Thr
1110 1115 1120 1125
gtt gtt gca cct gaa tcc atg cgc cca ttc gct gtg atc tcc ggt gac 3523
Val Val Ala Pro Glu Ser Met Arg Pro Phe Ala Val Ile Ser Gly Asp
1130 1135 1140
cgc aac cca att cac gtc tct gat gtt gcg gct tcc ctg gct ggt ctg 3571
Arg Asn Pro Ile His Val Ser Asp Val Ala Ala Ser Leu Ala Gly Leu
1145 1150 1155
cca ggt gtg atc gtg cac ggc atg tgg acc tct gcc atc ggt gaa ctg 3619
Pro Gly Val Ile Val His Gly Met Trp Thr Ser Ala Ile Gly Glu Leu
1160 1165 1170
atc gcc ggt gca gca ttc aac gat gag cag atc caa act ccc gca gcc 3667
Ile Ala Gly Ala Ala Phe Asn Asp Glu Gln Ile Gln Thr Pro Ala Ala
1175 1180 1185
aag gtc gtg gaa tac acc gca acc atg ctg gca cca gtt ctt cca ggt 3715
Lys Val Val Glu Tyr Thr Ala Thr Met Leu Ala Pro Val Leu Pro Gly
1190 1195 1200 1205
gaa gaa att gag ttc agc gtt gag cgc tcc gca gtg gac aac cgc cca 3763
Glu Glu Ile Glu Phe Ser Val Glu Arg Ser Ala Val Asp Asn Arg Pro
1210 1215 1220
gga atg gga gag gtc cgc acc gtt acc gca acc gtc aac ggc aac tta 3811
Gly Met Gly Glu Val Arg Thr Val Thr Ala Thr Val Asn Gly Asn Leu
1225 1230 1235
gtg ctt acc gcc acc gct gtt gtg gca gct cca tct act ttc tac gca 3859
Val Leu Thr Ala Thr Ala Val Val Ala Ala Pro Ser Thr Phe Tyr Ala
1240 1245 1250
ttc cca ggc cag ggc att cag tcc cag ggc atg ggt atg gaa gca cgc 3907
Phe Pro Gly Gln Gly Ile Gln Ser Gln Gly Met Gly Met Glu Ala Arg
1255 1260 1265
cgt aac tct cag gca gct cgc gct atc tgg gac cgc gcc gat gca cac 3955
Arg Asn Ser Gln Ala Ala Arg Ala Ile Trp Asp Arg Ala Asp Ala His
1270 1275 1280 1285
acc cgc aat aag ctg ggc ttc tcc atc gtg gaa atc gtg gaa aac aac 4003
Thr Arg Asn Lys Leu Gly Phe Ser Ile Val Glu Ile Val Glu Asn Asn
1290 1295 1300
cca cgc gaa gta acc gtg gca ggg gag aag ttc ttc cac cca gac ggc 4051
Pro Arg Glu Val Thr Val Ala Gly Glu Lys Phe Phe His Pro Asp Gly
1305 1310 1315
gtt ttg tac ctc acc cag ttc acc cag gtg ggc atg gca act ctg ggc 4099
Val Leu Tyr Leu Thr Gln Phe Thr Gln Val Gly Met Ala Thr Leu Gly
1320 1325 1330
gtt gct cag atc gct gaa atg cgt gaa gca cat gcc ttg aac cag cgt 4147
Val Ala Gln Ile Ala Glu Met Arg Glu Ala His Ala Leu Asn Gln Arg
1335 1340 1345
gca tac ttt gct gga cac tcc gtt ggt gag tac aac gcg ctt gct gca 4195
Ala Tyr Phe Ala Gly His Ser Val Gly Glu Tyr Asn Ala Leu Ala Ala
1350 1355 1360 1365
tat gct ggt gtg ctg tcc ctg gaa tcc gtt ctg gag atc gtt tac cgt 4243
Tyr Ala Gly Val Leu Ser Leu Glu Ser Val Leu Glu Ile Val Tyr Arg
1370 1375 1380
cgt ggc ttg acc atg cac cgc ttg gtg gat cgc gat gaa aac ggt ctg 4291
Arg Gly Leu Thr Met His Arg Leu Val Asp Arg Asp Glu Asn Gly Leu
1385 1390 1395
tcc aac tac gcg ctc gca gct ctt cgc ccc aac aag atg ggt ctg acc 4339
Ser Asn Tyr Ala Leu Ala Ala Leu Arg Pro Asn Lys Met Gly Leu Thr
1400 1405 1410
gca gac aac gtt ttc gat tac gtt gcg tct gtt tcc gaa gct tcc ggt 4387
Ala Asp Asn Val Phe Asp Tyr Val Ala Ser Val Ser Glu Ala Ser Gly
1415 1420 1425
gaa ttc ctg gag atc gtt aac tac aac ttg gct ggc ctg cag tac gca 4435
Glu Phe Leu Glu Ile Val Asn Tyr Asn Leu Ala Gly Leu Gln Tyr Ala
1430 1435 1440 1445
gtt gct gga acc cag gct ggt ctt gcc gcc ctt cgt gcc gat gtt gag 4483
Val Ala Gly Thr Gln Ala Gly Leu Ala Ala Leu Arg Ala Asp Val Glu
1450 1455 1460
aac cgt gca cca ggt cag cgt gcc ttc att ttg atc cct ggc att gac 4531
Asn Arg Ala Pro Gly Gln Arg Ala Phe Ile Leu Ile Pro Gly Ile Asp
1465 1470 1475
gtg cca ttc cac tcc tcc aag ctg cgc gac ggt gtg ggc gcg ttc cgt 4579
Val Pro Phe His Ser Ser Lys Leu Arg Asp Gly Val Gly Ala Phe Arg
1480 1485 1490
gag cac ctt gat tcc ctg atc cca gct gag ctg gat ctg gat gtg ctg 4627
Glu His Leu Asp Ser Leu Ile Pro Ala Glu Leu Asp Leu Asp Val Leu
1495 1500 1505
gtt ggc cgc tac att cca aac ttg gtg gct cgc cca ttc gaa ctc act 4675
Val Gly Arg Tyr Ile Pro Asn Leu Val Ala Arg Pro Phe Glu Leu Thr
1510 1515 1520 1525
gaa gag ttc gtg gca tcc atg gca gaa gtg gtg gag tcc acc tat gtc 4723
Glu Glu Phe Val Ala Ser Met Ala Glu Val Val Glu Ser Thr Tyr Val
1530 1535 1540
aat gag atc ttg gct gat ttc aag gct gct tcc gcc gat aag cag aag 4771
Asn Glu Ile Leu Ala Asp Phe Lys Ala Ala Ser Ala Asp Lys Gln Lys
1545 1550 1555
ctt gcc cgc acg ttg ctt att gag ctg ctt gca tgg cag ttc gca tca 4819
Leu Ala Arg Thr Leu Leu Ile Glu Leu Leu Ala Trp Gln Phe Ala Ser
1560 1565 1570
cct gtg cgc tgg atc gag act cag gat ctg ttg atc aag ggc ctt caa 4867
Pro Val Arg Trp Ile Glu Thr Gln Asp Leu Leu Ile Lys Gly Leu Gln
1575 1580 1585
gct gag cgt ttc gtg gag gtc ggt gtt ggc tct gct cca acg ctt gcc 4915
Ala Glu Arg Phe Val Glu Val Gly Val Gly Ser Ala Pro Thr Leu Ala
1590 1595 1600 1605
aac atg atg ggc cag acc ctg cgc ctt cct cag tac gcg gac gcc acc 4963
Asn Met Met Gly Gln Thr Leu Arg Leu Pro Gln Tyr Ala Asp Ala Thr
1610 1615 1620
att gag gtg tta aac att gag cgc gat cgc cca gtt gtg ttc gct acc 5011
Ile Glu Val Leu Asn Ile Glu Arg Asp Arg Pro Val Val Phe Ala Thr
1625 1630 1635
gat gag gtt gtg cgt gaa gtg gcg gtt gaa gag acc cca gca gct cct 5059
Asp Glu Val Val Arg Glu Val Ala Val Glu Glu Thr Pro Ala Ala Pro
1640 1645 1650
gca gaa acc act gaa acc cca gca acc cca gca acc cca gcc cct gtt 5107
Ala Glu Thr Thr Glu Thr Pro Ala Thr Pro Ala Thr Pro Ala Pro Val
1655 1660 1665
gca gct gca gcc cct gcc acc ggc ggc cct cgc cca gat gac atc agc 5155
Ala Ala Ala Ala Pro Ala Thr Gly Gly Pro Arg Pro Asp Asp Ile Ser
1670 1675 1680 1685
ttc act cct tct gat gcc act gaa atg ctc atc gct atc tgg acc aag 5203
Phe Thr Pro Ser Asp Ala Thr Glu Met Leu Ile Ala Ile Trp Thr Lys
1690 1695 1700
gtt cgc cca gat cag atg ggt gcc act gat tcc atc gag acc ctg gtt 5251
Val Arg Pro Asp Gln Met Gly Ala Thr Asp Ser Ile Glu Thr Leu Val
1705 1710 1715
gag ggc gtg tcc tct cgc cgt aac cag ctc ctg ctg gat ctt ggt gtg 5299
Glu Gly Val Ser Ser Arg Arg Asn Gln Leu Leu Leu Asp Leu Gly Val
1720 1725 1730
gag ttc ggc ctc ggc gca att gac gga gca gcc gat gct gag ctc ggt 5347
Glu Phe Gly Leu Gly Ala Ile Asp Gly Ala Ala Asp Ala Glu Leu Gly
1735 1740 1745
gat cta aag gtc acc gtg tcc aag atg gct aag ggc tac aag gcg ttt 5395
Asp Leu Lys Val Thr Val Ser Lys Met Ala Lys Gly Tyr Lys Ala Phe
1750 1755 1760 1765
ggc cct gtg ctc tcc gat gct gca gct gat gcc ctg cgt cgc ctc act 5443
Gly Pro Val Leu Ser Asp Ala Ala Ala Asp Ala Leu Arg Arg Leu Thr
1770 1775 1780
ggt cct acc ggt aag cgc ccg gga tac atc gca gag cgc gtc acc ggc 5491
Gly Pro Thr Gly Lys Arg Pro Gly Tyr Ile Ala Glu Arg Val Thr Gly
1785 1790 1795
acg tgg gaa ttg ggc cag ggc tgg gct gac cac gtg gtc gct gaa gtt 5539
Thr Trp Glu Leu Gly Gln Gly Trp Ala Asp His Val Val Ala Glu Val
1800 1805 1810
gtg atc ggc gcc cgc gaa ggc gca tcc ctg cgc ggc ggc gac ctg gcg 5587
Val Ile Gly Ala Arg Glu Gly Ala Ser Leu Arg Gly Gly Asp Leu Ala
1815 1820 1825
tca ctg tct cct gca agc cca gcg tct gca tca gat ctt gat tcg ctt 5635
Ser Leu Ser Pro Ala Ser Pro Ala Ser Ala Ser Asp Leu Asp Ser Leu
1830 1835 1840 1845
atc gac gca gcc gtc cag gcc gta gcc tcc cgc cgc ggc gtt gcg gtc 5683
Ile Asp Ala Ala Val Gln Ala Val Ala Ser Arg Arg Gly Val Ala Val
1850 1855 1860
tcc ctg cct tca gca ggc ggc gct gcc ggt ggc gtg gtt gat tcc gca 5731
Ser Leu Pro Ser Ala Gly Gly Ala Ala Gly Gly Val Val Asp Ser Ala
1865 1870 1875
gct ctt ggc gag ttt gca gag cag gtc acc gga cac gat ggt gtg ctt 5779
Ala Leu Gly Glu Phe Ala Glu Gln Val Thr Gly His Asp Gly Val Leu
1880 1885 1890
gct cag gca gcc cgc acc atc ttg acc cag ttg ggt ctt gat aag cca 5827
Ala Gln Ala Ala Arg Thr Ile Leu Thr Gln Leu Gly Leu Asp Lys Pro
1895 1900 1905
gca acc gtt tcc gtg gaa gac acc gca gag gaa gac ctc tac gag ttg 5875
Ala Thr Val Ser Val Glu Asp Thr Ala Glu Glu Asp Leu Tyr Glu Leu
1910 1915 1920 1925
gtc tcc aag gaa ctc ggt tct gat tgg cca cgt cag gtt gca cca agc 5923
Val Ser Lys Glu Leu Gly Ser Asp Trp Pro Arg Gln Val Ala Pro Ser
1930 1935 1940
ttc gat gaa gaa aag gtt gtt ctg ctt gat gac cgt tgg gct tct gcg 5971
Phe Asp Glu Glu Lys Val Val Leu Leu Asp Asp Arg Trp Ala Ser Ala
1945 1950 1955
cgt gag gat ctc tcc gcg ttg ctc ttg gcg aac tcg cag caa ctg ata 6019
Arg Glu Asp Leu Ser Ala Leu Leu Leu Ala Asn Ser Gln Gln Leu Ile
1960 1965 1970
tcg atg tca cag gcg cag gcg aag ctg ttg cag cac aag ctg aat tct 6067
Ser Met Ser Gln Ala Gln Ala Lys Leu Leu Gln His Lys Leu Asn Ser
1975 1980 1985
ttg gac ttg atg atc tcg cag cta ggc tcg cga aca aag ctt ctt gga 6115
Leu Asp Leu Met Ile Ser Gln Leu Gly Ser Arg Thr Lys Leu Leu Gly
1990 1995 2000 2005
cta cgc cga caa tgt tgc ggc 6136
Leu Arg Arg Gln Cys Cys Gly
2010
<210> 50
<211> 2012
<212> PRT
<213> Corynebacterium glutamicum
<400> 50
Leu Lys Thr Leu Arg Ala Ala Val Ala Ala Gly Ala Gly Thr Asn Val
1 5 10 15
Ser Asp Ile Val Glu Arg Ala Asn Ala Leu Leu Ala Leu Val Ala Asp
20 25 30
Asp Leu Ile Gly Thr Leu Pro Phe Gly Phe Asp Pro Val Ala Trp Ala
35 40 45
Asn Asn Ser Glu Asp Pro Ala Phe Asp Thr Ala Gln Ser Ala Val Ser
50 55 60
Val Pro Gly Ile Phe Val Ser Gln Ile Ala Thr Leu Asp Ser Leu Glu
65 70 75 80
Ala Gln Arg Leu Asp Val Asp Gln Ala Val Ser Ser Ile Gly His Ser
85 90 95
Gln Gly Val Leu Gly Val His Leu Leu Asn Asp Ala Thr Arg Ala Asp
100 105 110
Glu Leu Val Ala Ile Ala Gln Leu Ile Gly Ala Ala Ile Thr Arg Thr
115 120 125
Ala Arg Met Thr Gly Leu Ile Ala Gln Gly Asp Asn Met Pro Met Leu
130 135 140
Ser Ile Ala Gly Ile Ser Arg Glu Gln Leu Gln Gln Ala Ile Asp Ala
145 150 155 160
Ala Cys Ala Glu Val Pro Ala Glu Ile Arg Pro Val Ile Gly Leu Arg
165 170 175
Asn Ser Arg Asp Ser Tyr Val Leu Val Gly Arg Pro Asp Asp Asn Ala
180 185 190
Arg Val Val Lys Val Ile Glu Ala Met Ala Ala Lys Asp Lys Lys Ala
195 200 205
Ile Glu Asp Lys Leu Arg Gly Gly Ser Ala Phe Ser Pro Arg Ile Thr
210 215 220
Pro Leu Lys Val Gln Ala Ala Phe His His Pro Ala Met Asn Met Ala
225 230 235 240
Val Glu Gln Thr Val Ala Trp Ala Thr Thr Ala Gly Leu Asp Val Glu
245 250 255
Leu Thr Arg Glu Ile Ala Ala Asp Val Leu Val Asn Pro Val Asp Trp
260 265 270
Val Ala Arg Val Asn Glu Ala Tyr Glu Ala Gly Ala Arg Trp Phe Leu
275 280 285
Asp Val Gly Pro Asp Gly Gly Ile Val Lys Leu Thr Ala Asn Ile Leu
290 295 300
Glu Gly Arg Gly Ala Asp Ser Phe Tyr Val Gly Asp Ala Ala Gly Gln
305 310 315 320
Ala Lys Ile Phe Asp Ala Gly Met Ala Pro Glu Leu Pro Val Asp Tyr
325 330 335
Gln Glu Phe Ala Pro Arg Val Glu His Val Asp Gly Thr Pro Arg Leu
340 345 350
Val Thr Lys Phe Thr Glu Leu Thr Gly Arg Thr Pro Met Met Leu Ala
355 360 365
Gly Met Thr Pro Thr Thr Val Asp Pro Ala Ile Val Ala Ala Ala Ala
370 375 380
Asn Gly Gly His Trp Ala Glu Leu Ala Gly Gly Gly Gln Val Thr Pro
385 390 395 400
Glu Leu Leu Glu Thr His Ile Ala Gln Leu Thr Asp Met Leu Glu Pro
405 410 415
Gly Ile Asn Ala Gln Phe Asn Ser Met Phe Leu Asp Pro Tyr Leu Trp
420 425 430
Lys Met Gln Ile Gly Gly Lys Arg Leu Val Pro Lys Ala Arg Ala Asn
435 440 445
Gly Ala Ser Ile Asp Gly Ile Val Ile Thr Ala Gly Ile Pro Glu Lys
450 455 460
Asp Glu Ala Val Ala Leu Val Lys Glu Leu Met Arg Asp Gly Phe Pro
465 470 475 480
Trp Ile Ala Phe Lys Pro Gly Ala Ile Lys Gln Val Asn Ser Val Leu
485 490 495
Ala Ile Ala Lys Glu Val Pro Glu Leu Pro Ile Ile Ile Gln Ile Glu
500 505 510
Gly Gly Val Ala Gly Gly His His Ser Trp Glu Asp Leu Asp Glu Leu
515 520 525
Leu Ile Ala Thr Tyr Gly Lys Val Arg Ala Leu Asp Asn Val Val Leu
530 535 540
Cys Val Gly Gly Gly Ile Gly Ser Pro Glu Arg Ala Ala Asp Tyr Val
545 550 555 560
Thr Gly Ser Trp Ser Thr Ser Tyr Gly Leu Pro Ala Met Pro Val Asp
565 570 575
Gly Ile Leu Val Gly Thr Ala Ala Met Ala Thr Lys Glu Ala Thr Thr
580 585 590
Ser Gln Ala Val Lys Glu Leu Leu Val Ser Thr Gln Gly Ser Asp Glu
595 600 605
Trp Val Pro Ala Gly Gly Ala Lys Asn Gly Met Ala Ser Gly Arg Ser
610 615 620
Gln Leu Gly Ala Asp Ile His Glu Ile Asp Asn Ser Phe Ala Lys Ala
625 630 635 640
Gly Arg Leu Leu Asp Glu Val Ala Gly Asp Glu Thr Ala Val Gln Ala
645 650 655
Arg Arg Asp Glu Ile Ile Glu Ala Ile Gly Lys Thr Ala Lys Val Tyr
660 665 670
Phe Gly Asp Ile Gly Ser Met Thr Tyr Glu Gln Trp Leu Asn Arg Tyr
675 680 685
Leu Glu Leu Ser Gly Pro Val Asp Gly Gln Trp Ile Asp Ala Ser Trp
690 695 700
Ala Ala Arg Phe Ala Gln Met Leu Glu Arg Ala Glu Ala Arg Leu Ile
705 710 715 720
Glu Gln Asp His Gly Gln Phe Glu Pro Ser Leu Thr Val Glu Asp Gly
725 730 735
Val Asp Lys Leu Val Ala Ala Tyr Pro His Ala Ala Thr Asp Leu Leu
740 745 750
Thr Pro Ala Asp Val Ala Trp Phe Leu Gly Leu Cys Arg Thr Pro Gly
755 760 765
Lys Pro Val Asn Phe Val Pro Val Ile Asp Lys Asp Val Arg Arg Trp
770 775 780
Trp Arg Ser Asp Ser Leu Trp Gln Ser His Asp Asp Arg Tyr Thr Ala
785 790 795 800
Asp Gln Val Ala Ile Ile Pro Gly Val Val Ala Val Ala Gly Ile Thr
805 810 815
Lys Ala Asn Glu Pro Val Ala Asp Leu Leu Asp Arg Phe Val Asp Ala
820 825 830
Thr Ile Glu Arg Ile Asp Glu His Asp Ser Arg Ser Arg Asp Ile Met
835 840 845
Gly Lys Val Leu Ser Ser Pro Gly Thr Phe Trp Ala Gly Arg Asn Ile
850 855 860
Pro Ser Val Ile His Ser Leu Gly His Ala Asp Lys Trp Ser Arg Ser
865 870 875 880
Glu Phe Glu Ala Phe His Ser Pro Thr Gly Ala Asn Leu Val Tyr Glu
885 890 895
Asp Ala Glu His Ala Met Leu Thr Val Pro Leu Ala Gly Ser Thr Ala
900 905 910
Phe Gly Thr Thr Ala Glu Leu Lys Ile Arg Phe Thr Ser Pro Ile Asp
915 920 925
Ala Leu Pro Ser Ala Val Pro Leu Val Thr Gln Glu Asp Ala Glu Ala
930 935 940
Ala Met Gly Glu Leu Thr Arg Ile Ala Ala Gly Gly Thr Leu Ala Thr
945 950 955 960
Val Asn Asn Gly Thr Ala Thr Trp Glu Thr Ser Val Asp Ala Gly Val
965 970 975
Ile Ala Asp Tyr Asn Asn Val Thr Ala Gly Tyr Leu Pro Ala Ser Val
980 985 990
Val Pro Ala His Thr Ala Pro Asp Val Leu Val Gly Arg Ala Trp Pro
995 1000 1005
Ala Val Phe Ala Ala Val Lys Ser Ala Val Ile Pro Gly Thr Asp Ser
1010 1015 1020
Ala Ser Val Val Glu Gly Met Leu Ser Leu Val His Leu Glu His His
1025 1030 1035 1040
Ile Val Leu Lys Ser Asp Val Pro Thr Asp Gly Ala Leu Lys Val Ser
1045 1050 1055
Ala Thr Ala Asp Glu Val Val Asp Thr Asp Leu Gly Arg Leu Val Ile
1060 1065 1070
Val Arg Ala Glu Ile Ala Asp Ala Glu Gly Asn Leu Ile Ala Thr Leu
1075 1080 1085
Ala Glu Arg Phe Ala Ile Arg Gly Arg Lys Gly Asn Ala Val Ala Arg
1090 1095 1100
Thr Asn Thr Ser Ala Leu Pro Thr Thr Val Asp Thr Pro Arg Ser Ala
1105 1110 1115 1120
Arg Ala Val Ala Thr Val Val Ala Pro Glu Ser Met Arg Pro Phe Ala
1125 1130 1135
Val Ile Ser Gly Asp Arg Asn Pro Ile His Val Ser Asp Val Ala Ala
1140 1145 1150
Ser Leu Ala Gly Leu Pro Gly Val Ile Val His Gly Met Trp Thr Ser
1155 1160 1165
Ala Ile Gly Glu Leu Ile Ala Gly Ala Ala Phe Asn Asp Glu Gln Ile
1170 1175 1180
Gln Thr Pro Ala Ala Lys Val Val Glu Tyr Thr Ala Thr Met Leu Ala
1185 1190 1195 1200
Pro Val Leu Pro Gly Glu Glu Ile Glu Phe Ser Val Glu Arg Ser Ala
1205 1210 1215
Val Asp Asn Arg Pro Gly Met Gly Glu Val Arg Thr Val Thr Ala Thr
1220 1225 1230
Val Asn Gly Asn Leu Val Leu Thr Ala Thr Ala Val Val Ala Ala Pro
1235 1240 1245
Ser Thr Phe Tyr Ala Phe Pro Gly Gln Gly Ile Gln Ser Gln Gly Met
1250 1255 1260
Gly Met Glu Ala Arg Arg Asn Ser Gln Ala Ala Arg Ala Ile Trp Asp
1265 1270 1275 1280
Arg Ala Asp Ala His Thr Arg Asn Lys Leu Gly Phe Ser Ile Val Glu
1285 1290 1295
Ile Val Glu Asn Asn Pro Arg Glu Val Thr Val Ala Gly Glu Lys Phe
1300 1305 1310
Phe His Pro Asp Gly Val Leu Tyr Leu Thr Gln Phe Thr Gln Val Gly
1315 1320 1325
Met Ala Thr Leu Gly Val Ala Gln Ile Ala Glu Met Arg Glu Ala His
1330 1335 1340
Ala Leu Asn Gln Arg Ala Tyr Phe Ala Gly His Ser Val Gly Glu Tyr
1345 1350 1355 1360
Asn Ala Leu Ala Ala Tyr Ala Gly Val Leu Ser Leu Glu Ser Val Leu
1365 1370 1375
Glu Ile Val Tyr Arg Arg Gly Leu Thr Met His Arg Leu Val Asp Arg
1380 1385 1390
Asp Glu Asn Gly Leu Ser Asn Tyr Ala Leu Ala Ala Leu Arg Pro Asn
1395 1400 1405
Lys Met Gly Leu Thr Ala Asp Asn Val Phe Asp Tyr Val Ala Ser Val
1410 1415 1420
Ser Glu Ala Ser Gly Glu Phe Leu Glu Ile Val Asn Tyr Asn Leu Ala
1425 1430 1435 1440
Gly Leu Gln Tyr Ala Val Ala Gly Thr Gln Ala Gly Leu Ala Ala Leu
1445 1450 1455
Arg Ala Asp Val Glu Asn Arg Ala Pro Gly Gln Arg Ala Phe Ile Leu
1460 1465 1470
Ile Pro Gly Ile Asp Val Pro Phe His Ser Ser Lys Leu Arg Asp Gly
1475 1480 1485
Val Gly Ala Phe Arg Glu His Leu Asp Ser Leu Ile Pro Ala Glu Leu
1490 1495 1500
Asp Leu Asp Val Leu Val Gly Arg Tyr Ile Pro Asn Leu Val Ala Arg
1505 1510 1515 1520
Pro Phe Glu Leu Thr Glu Glu Phe Val Ala Ser Met Ala Glu Val Val
1525 1530 1535
Glu Ser Thr Tyr Val Asn Glu Ile Leu Ala Asp Phe Lys Ala Ala Ser
1540 1545 1550
Ala Asp Lys Gln Lys Leu Ala Arg Thr Leu Leu Ile Glu Leu Leu Ala
1555 1560 1565
Trp Gln Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gln Asp Leu Leu
1570 1575 1580
Ile Lys Gly Leu Gln Ala Glu Arg Phe Val Glu Val Gly Val Gly Ser
1585 1590 1595 1600
Ala Pro Thr Leu Ala Asn Met Met Gly Gln Thr Leu Arg Leu Pro Gln
1605 1610 1615
Tyr Ala Asp Ala Thr Ile Glu Val Leu Asn Ile Glu Arg Asp Arg Pro
1620 1625 1630
Val Val Phe Ala Thr Asp Glu Val Val Arg Glu Val Ala Val Glu Glu
1635 1640 1645
Thr Pro Ala Ala Pro Ala Glu Thr Thr Glu Thr Pro Ala Thr Pro Ala
1650 1655 1660
Thr Pro Ala Pro Val Ala Ala Ala Ala Pro Ala Thr Gly Gly Pro Arg
1665 1670 1675 1680
Pro Asp Asp Ile Ser Phe Thr Pro Ser Asp Ala Thr Glu Met Leu Ile
1685 1690 1695
Ala Ile Trp Thr Lys Val Arg Pro Asp Gln Met Gly Ala Thr Asp Ser
1700 1705 1710
Ile Glu Thr Leu Val Glu Gly Val Ser Ser Arg Arg Asn Gln Leu Leu
1715 1720 1725
Leu Asp Leu Gly Val Glu Phe Gly Leu Gly Ala Ile Asp Gly Ala Ala
1730 1735 1740
Asp Ala Glu Leu Gly Asp Leu Lys Val Thr Val Ser Lys Met Ala Lys
1745 1750 1755 1760
Gly Tyr Lys Ala Phe Gly Pro Val Leu Ser Asp Ala Ala Ala Asp Ala
1765 1770 1775
Leu Arg Arg Leu Thr Gly Pro Thr Gly Lys Arg Pro Gly Tyr Ile Ala
1780 1785 1790
Glu Arg Val Thr Gly Thr Trp Glu Leu Gly Gln Gly Trp Ala Asp His
1795 1800 1805
Val Val Ala Glu Val Val Ile Gly Ala Arg Glu Gly Ala Ser Leu Arg
1810 1815 1820
Gly Gly Asp Leu Ala Ser Leu Ser Pro Ala Ser Pro Ala Ser Ala Ser
1825 1830 1835 1840
Asp Leu Asp Ser Leu Ile Asp Ala Ala Val Gln Ala Val Ala Ser Arg
1845 1850 1855
Arg Gly Val Ala Val Ser Leu Pro Ser Ala Gly Gly Ala Ala Gly Gly
1860 1865 1870
Val Val Asp Ser Ala Ala Leu Gly Glu Phe Ala Glu Gln Val Thr Gly
1875 1880 1885
His Asp Gly Val Leu Ala Gln Ala Ala Arg Thr Ile Leu Thr Gln Leu
1890 1895 1900
Gly Leu Asp Lys Pro Ala Thr Val Ser Val Glu Asp Thr Ala Glu Glu
1905 1910 1915 1920
Asp Leu Tyr Glu Leu Val Ser Lys Glu Leu Gly Ser Asp Trp Pro Arg
1925 1930 1935
Gln Val Ala Pro Ser Phe Asp Glu Glu Lys Val Val Leu Leu Asp Asp
1940 1945 1950
Arg Trp Ala Ser Ala Arg Glu Asp Leu Ser Ala Leu Leu Leu Ala Asn
1955 1960 1965
Ser Gln Gln Leu Ile Ser Met Ser Gln Ala Gln Ala Lys Leu Leu Gln
1970 1975 1980
His Lys Leu Asn Ser Leu Asp Leu Met Ile Ser Gln Leu Gly Ser Arg
1985 1990 1995 2000
Thr Lys Leu Leu Gly Leu Arg Arg Gln Cys Cys Gly
2005 2010
<210> 51
<211> 2185
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(2185)
<223> FRXA00158
<400> 51
cgtgccattt tctttacaaa agagtattaa ccgaaacttc aggtcaggat ccacgccctg 60
cgttcatccc ggctaagtta tacaaggagc gagttctcac gtg acc gaa ttg agc 115
Val Thr Glu Leu Ser
1 5
agg aac ttc ggg gcc agc cga ctg att aac cgc ttt ggc cag gag cct 163
Arg Asn Phe Gly Ala Ser Arg Leu Ile Asn Arg Phe Gly Gln Glu Pro
10 15 20
ttt gcc ttc gct ttc gcc ggc caa gga tat gac tgg ttg aag acc ctt 211
Phe Ala Phe Ala Phe Ala Gly Gln Gly Tyr Asp Trp Leu Lys Thr Leu
25 30 35
cgt gcc gcg gtt gcc gca ggt gca ggc acc aat gtt agt gac atc gtc 259
Arg Ala Ala Val Ala Ala Gly Ala Gly Thr Asn Val Ser Asp Ile Val
40 45 50
gag cgc gca aat gcg ctg ctt gca cta gtt gca gat gat ctc att ggc 307
Glu Arg Ala Asn Ala Leu Leu Ala Leu Val Ala Asp Asp Leu Ile Gly
55 60 65
acc ctt cca ttt ggt ttc gat cca gtg gct tgg gct aac aac tcc gaa 355
Thr Leu Pro Phe Gly Phe Asp Pro Val Ala Trp Ala Asn Asn Ser Glu
70 75 80 85
gat cca gct ttc gat act gca caa tct gca gtg agc gtg ccg ggt atc 403
Asp Pro Ala Phe Asp Thr Ala Gln Ser Ala Val Ser Val Pro Gly Ile
90 95 100
ttt gtc tcc cag atc gca acc ctg gat tcc ctt gag gcg cag cgc ctt 451
Phe Val Ser Gln Ile Ala Thr Leu Asp Ser Leu Glu Ala Gln Arg Leu
105 110 115
gat gtg gat cag gct gtg tcc agc att ggt cat tcc cag ggc gta ttg 499
Asp Val Asp Gln Ala Val Ser Ser Ile Gly His Ser Gln Gly Val Leu
120 125 130
ggc gtg cac ctg ctc aat gat gcg act cgt gct gat gaa ctc gtt gcc 547
Gly Val His Leu Leu Asn Asp Ala Thr Arg Ala Asp Glu Leu Val Ala
135 140 145
att gcg cag ttg atc ggt gca gcg atc acc cgc acc gca cgc atg acg 595
Ile Ala Gln Leu Ile Gly Ala Ala Ile Thr Arg Thr Ala Arg Met Thr
150 155 160 165
ggc ctg atc gcg cag ggc gac aac atg ccg atg ctg tcg atc gcc gga 643
Gly Leu Ile Ala Gln Gly Asp Asn Met Pro Met Leu Ser Ile Ala Gly
170 175 180
att tcc cgc gaa cag ctt cag caa gct atc gac gcg gcc tgc gcc gaa 691
Ile Ser Arg Glu Gln Leu Gln Gln Ala Ile Asp Ala Ala Cys Ala Glu
185 190 195
gtc cct gcg gag atc cgc ccg gtt atc ggt ctg cgc aac tca cgc gat 739
Val Pro Ala Glu Ile Arg Pro Val Ile Gly Leu Arg Asn Ser Arg Asp
200 205 210
tct tat gtt ttg gtt ggc cgc cca gac gac aac gct cgc gtt gtt aag 787
Ser Tyr Val Leu Val Gly Arg Pro Asp Asp Asn Ala Arg Val Val Lys
215 220 225
gtc att gag gca atg gct gcc aag gat aag aag gcc att gaa gat aag 835
Val Ile Glu Ala Met Ala Ala Lys Asp Lys Lys Ala Ile Glu Asp Lys
230 235 240 245
ctg cgc ggc ggt tcc gcg ttc agc ccc cgt att act ccg ctg aag gtg 883
Leu Arg Gly Gly Ser Ala Phe Ser Pro Arg Ile Thr Pro Leu Lys Val
250 255 260
cag gct gct ttc cat cac cca gct atg aac atg gct gtg gag cag acc 931
Gln Ala Ala Phe His His Pro Ala Met Asn Met Ala Val Glu Gln Thr
265 270 275
gtg gcg tgg gca acc act gct ggt ttg gat gtg gaa ctc acc cgc gag 979
Val Ala Trp Ala Thr Thr Ala Gly Leu Asp Val Glu Leu Thr Arg Glu
280 285 290
atc gcc gct gat gtt ttg gtt aac cct gtc gat tgg gta gca cgc gtc 1027
Ile Ala Ala Asp Val Leu Val Asn Pro Val Asp Trp Val Ala Arg Val
295 300 305
aac gaa gcg tat gag gct ggc gct cgc tgg ttc ctc gac gtt gga cca 1075
Asn Glu Ala Tyr Glu Ala Gly Ala Arg Trp Phe Leu Asp Val Gly Pro
310 315 320 325
gat ggt ggc atc gtt aag ctg act gcc aac atc ctt gag ggc cgc ggc 1123
Asp Gly Gly Ile Val Lys Leu Thr Ala Asn Ile Leu Glu Gly Arg Gly
330 335 340
gcg gat tcc ttc tat gtt ggt gac gcc gca ggc cag gcc aag ata ttt 1171
Ala Asp Ser Phe Tyr Val Gly Asp Ala Ala Gly Gln Ala Lys Ile Phe
345 350 355
gat gct ggc atg gca cct gaa ctt cca gtg gat tac cag gag ttc gca 1219
Asp Ala Gly Met Ala Pro Glu Leu Pro Val Asp Tyr Gln Glu Phe Ala
360 365 370
cca cgc gtt gag cac gtt gat gga acc cca cgc ctg gtt acc aag ttc 1267
Pro Arg Val Glu His Val Asp Gly Thr Pro Arg Leu Val Thr Lys Phe
375 380 385
act gag ctg acc ggc cgc acc cca atg atg ctg gct ggc atg acc cca 1315
Thr Glu Leu Thr Gly Arg Thr Pro Met Met Leu Ala Gly Met Thr Pro
390 395 400 405
acc acc gtt gac cct gcc att gtt gca gcc gct gca aac ggt gga cac 1363
Thr Thr Val Asp Pro Ala Ile Val Ala Ala Ala Ala Asn Gly Gly His
410 415 420
tgg gct gag ctc gct ggt ggc gga cag gtt acc cca gag ctg ctg gaa 1411
Trp Ala Glu Leu Ala Gly Gly Gly Gln Val Thr Pro Glu Leu Leu Glu
425 430 435
acc cac atc gca cag ctc acc gac atg ctt gag cca ggt atc aac gcc 1459
Thr His Ile Ala Gln Leu Thr Asp Met Leu Glu Pro Gly Ile Asn Ala
440 445 450
cag ttc aac tcc atg ttc ttg gat cca tac ctg tgg aag atg cag att 1507
Gln Phe Asn Ser Met Phe Leu Asp Pro Tyr Leu Trp Lys Met Gln Ile
455 460 465
ggt ggc aag cgc ctt gtt cct aag gcc cgc gct aat ggt gca tcc atc 1555
Gly Gly Lys Arg Leu Val Pro Lys Ala Arg Ala Asn Gly Ala Ser Ile
470 475 480 485
gac ggc atc gtc atc acc gcc ggc att cct gaa aag gat gaa gct gtt 1603
Asp Gly Ile Val Ile Thr Ala Gly Ile Pro Glu Lys Asp Glu Ala Val
490 495 500
gca ttg gtc aag gaa ctg atg cgt gat ggt ttc cct tgg atc gca ttc 1651
Ala Leu Val Lys Glu Leu Met Arg Asp Gly Phe Pro Trp Ile Ala Phe
505 510 515
aag cca ggt gcc atc aag cag gtt aac tct gtg ttg gct atc gct aag 1699
Lys Pro Gly Ala Ile Lys Gln Val Asn Ser Val Leu Ala Ile Ala Lys
520 525 530
gaa gtt cca gaa ctc ccc atc atc att cag att gag ggt ggc gtt gca 1747
Glu Val Pro Glu Leu Pro Ile Ile Ile Gln Ile Glu Gly Gly Val Ala
535 540 545
ggt gga cac cac tct tgg gaa gac ctc gat gag ctg ctg atc gcc acc 1795
Gly Gly His His Ser Trp Glu Asp Leu Asp Glu Leu Leu Ile Ala Thr
550 555 560 565
tac ggc aag gtc cgc gca ctg gat aac gtg gtg ctg tgt gtc ggc ggt 1843
Tyr Gly Lys Val Arg Ala Leu Asp Asn Val Val Leu Cys Val Gly Gly
570 575 580
ggc att ggc tca cct gag cgc gct gct gat tac gtc acc ggt tcc tgg 1891
Gly Ile Gly Ser Pro Glu Arg Ala Ala Asp Tyr Val Thr Gly Ser Trp
585 590 595
tcc act tcc tac ggc ctg cca gct atg cct gtt gat ggc atc ttg gtg 1939
Ser Thr Ser Tyr Gly Leu Pro Ala Met Pro Val Asp Gly Ile Leu Val
600 605 610
ggt acc gct gcg atg gca acc aag gaa gca acc acc tcc cag gcc gtc 1987
Gly Thr Ala Ala Met Ala Thr Lys Glu Ala Thr Thr Ser Gln Ala Val
615 620 625
aag gaa ctt ctt gtt tcc acc cag ggc tct gat gaa tgg gtt cct gct 2035
Lys Glu Leu Leu Val Ser Thr Gln Gly Ser Asp Glu Trp Val Pro Ala
630 635 640 645
ggt ggc gca aag aac gga atg gca tat ggc cgt tcc cag ctt ggc gca 2083
Gly Gly Ala Lys Asn Gly Met Ala Tyr Gly Arg Ser Gln Leu Gly Ala
650 655 660
gac atc cac gag atc gac aac tcc ttt gct aag gct gga cgc ctt ctt 2131
Asp Ile His Glu Ile Asp Asn Ser Phe Ala Lys Ala Gly Arg Leu Leu
665 670 675
gat gag gtt gca ggc cat gaa acg gat ttg caa gcg cgc ccg gat gag 2179
Asp Glu Val Ala Gly His Glu Thr Asp Leu Gln Ala Arg Pro Asp Glu
680 685 690
atc att 2185
Ile Ile
695
<210> 52
<211> 695
<212> PRT
<213> Corynebacterium glutamicum
<400> 52
Val Thr Glu Leu Ser Arg Asn Phe Gly Ala Ser Arg Leu Ile Asn Arg
1 5 10 15
Phe Gly Gln Glu Pro Phe Ala Phe Ala Phe Ala Gly Gln Gly Tyr Asp
20 25 30
Trp Leu Lys Thr Leu Arg Ala Ala Val Ala Ala Gly Ala Gly Thr Asn
35 40 45
Val Ser Asp Ile Val Glu Arg Ala Asn Ala Leu Leu Ala Leu Val Ala
50 55 60
Asp Asp Leu Ile Gly Thr Leu Pro Phe Gly Phe Asp Pro Val Ala Trp
65 70 75 80
Ala Asn Asn Ser Glu Asp Pro Ala Phe Asp Thr Ala Gln Ser Ala Val
85 90 95
Ser Val Pro Gly Ile Phe Val Ser Gln Ile Ala Thr Leu Asp Ser Leu
100 105 110
Glu Ala Gln Arg Leu Asp Val Asp Gln Ala Val Ser Ser Ile Gly His
115 120 125
Ser Gln Gly Val Leu Gly Val His Leu Leu Asn Asp Ala Thr Arg Ala
130 135 140
Asp Glu Leu Val Ala Ile Ala Gln Leu Ile Gly Ala Ala Ile Thr Arg
145 150 155 160
Thr Ala Arg Met Thr Gly Leu Ile Ala Gln Gly Asp Asn Met Pro Met
165 170 175
Leu Ser Ile Ala Gly Ile Ser Arg Glu Gln Leu Gln Gln Ala Ile Asp
180 185 190
Ala Ala Cys Ala Glu Val Pro Ala Glu Ile Arg Pro Val Ile Gly Leu
195 200 205
Arg Asn Ser Arg Asp Ser Tyr Val Leu Val Gly Arg Pro Asp Asp Asn
210 215 220
Ala Arg Val Val Lys Val Ile Glu Ala Met Ala Ala Lys Asp Lys Lys
225 230 235 240
Ala Ile Glu Asp Lys Leu Arg Gly Gly Ser Ala Phe Ser Pro Arg Ile
245 250 255
Thr Pro Leu Lys Val Gln Ala Ala Phe His His Pro Ala Met Asn Met
260 265 270
Ala Val Glu Gln Thr Val Ala Trp Ala Thr Thr Ala Gly Leu Asp Val
275 280 285
Glu Leu Thr Arg Glu Ile Ala Ala Asp Val Leu Val Asn Pro Val Asp
290 295 300
Trp Val Ala Arg Val Asn Glu Ala Tyr Glu Ala Gly Ala Arg Trp Phe
305 310 315 320
Leu Asp Val Gly Pro Asp Gly Gly Ile Val Lys Leu Thr Ala Asn Ile
325 330 335
Leu Glu Gly Arg Gly Ala Asp Ser Phe Tyr Val Gly Asp Ala Ala Gly
340 345 350
Gln Ala Lys Ile Phe Asp Ala Gly Met Ala Pro Glu Leu Pro Val Asp
355 360 365
Tyr Gln Glu Phe Ala Pro Arg Val Glu His Val Asp Gly Thr Pro Arg
370 375 380
Leu Val Thr Lys Phe Thr Glu Leu Thr Gly Arg Thr Pro Met Met Leu
385 390 395 400
Ala Gly Met Thr Pro Thr Thr Val Asp Pro Ala Ile Val Ala Ala Ala
405 410 415
Ala Asn Gly Gly His Trp Ala Glu Leu Ala Gly Gly Gly Gln Val Thr
420 425 430
Pro Glu Leu Leu Glu Thr His Ile Ala Gln Leu Thr Asp Met Leu Glu
435 440 445
Pro Gly Ile Asn Ala Gln Phe Asn Ser Met Phe Leu Asp Pro Tyr Leu
450 455 460
Trp Lys Met Gln Ile Gly Gly Lys Arg Leu Val Pro Lys Ala Arg Ala
465 470 475 480
Asn Gly Ala Ser Ile Asp Gly Ile Val Ile Thr Ala Gly Ile Pro Glu
485 490 495
Lys Asp Glu Ala Val Ala Leu Val Lys Glu Leu Met Arg Asp Gly Phe
500 505 510
Pro Trp Ile Ala Phe Lys Pro Gly Ala Ile Lys Gln Val Asn Ser Val
515 520 525
Leu Ala Ile Ala Lys Glu Val Pro Glu Leu Pro Ile Ile Ile Gln Ile
530 535 540
Glu Gly Gly Val Ala Gly Gly His His Ser Trp Glu Asp Leu Asp Glu
545 550 555 560
Leu Leu Ile Ala Thr Tyr Gly Lys Val Arg Ala Leu Asp Asn Val Val
565 570 575
Leu Cys Val Gly Gly Gly Ile Gly Ser Pro Glu Arg Ala Ala Asp Tyr
580 585 590
Val Thr Gly Ser Trp Ser Thr Ser Tyr Gly Leu Pro Ala Met Pro Val
595 600 605
Asp Gly Ile Leu Val Gly Thr Ala Ala Met Ala Thr Lys Glu Ala Thr
610 615 620
Thr Ser Gln Ala Val Lys Glu Leu Leu Val Ser Thr Gln Gly Ser Asp
625 630 635 640
Glu Trp Val Pro Ala Gly Gly Ala Lys Asn Gly Met Ala Tyr Gly Arg
645 650 655
Ser Gln Leu Gly Ala Asp Ile His Glu Ile Asp Asn Ser Phe Ala Lys
660 665 670
Ala Gly Arg Leu Leu Asp Glu Val Ala Gly His Glu Thr Asp Leu Gln
675 680 685
Ala Arg Pro Asp Glu Ile Ile
690 695
<210> 53
<211> 3831
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(3831)
<223> FRXA00572
<400> 53
cag tgg ctc aac cgc tac ctc gag ctg tct ggc cct gtt gat ggt cag 48
Gln Trp Leu Asn Arg Tyr Leu Glu Leu Ser Gly Pro Val Asp Gly Gln
1 5 10 15
tgg att gat gct tcc tgg gct gca cgt ttt gcc cag atg ctg gag cgt 96
Trp Ile Asp Ala Ser Trp Ala Ala Arg Phe Ala Gln Met Leu Glu Arg
20 25 30
gcc gag gcg cgt ttg atc gag cag gat cat ggc caa ttt gag cca agc 144
Ala Glu Ala Arg Leu Ile Glu Gln Asp His Gly Gln Phe Glu Pro Ser
35 40 45
ctg acg gtg gag gat ggc gtc gac aag ctt gtt gct gct tac ccg cat 192
Leu Thr Val Glu Asp Gly Val Asp Lys Leu Val Ala Ala Tyr Pro His
50 55 60
gcc gca acc gac ctg ctc acc ccg gct gat gtc gcc tgg ttc ttg ggc 240
Ala Ala Thr Asp Leu Leu Thr Pro Ala Asp Val Ala Trp Phe Leu Gly
65 70 75 80
ctg tgc cgc acg ccg ggc aag cct gtg aac ttt gtg ccc gtc att gat 288
Leu Cys Arg Thr Pro Gly Lys Pro Val Asn Phe Val Pro Val Ile Asp
85 90 95
aag gac gtg cgt cgc tgg tgg cgc tcg gac tcc ctg tgg cag tcc cac 336
Lys Asp Val Arg Arg Trp Trp Arg Ser Asp Ser Leu Trp Gln Ser His
100 105 110
gat gat cgc tac acc gct gat cag gtg gct att atc cct ggt gtc gtc 384
Asp Asp Arg Tyr Thr Ala Asp Gln Val Ala Ile Ile Pro Gly Val Val
115 120 125
gcc gtt gct ggc atc acc aag gcc aac gaa cct gtc gct gac ctg ctt 432
Ala Val Ala Gly Ile Thr Lys Ala Asn Glu Pro Val Ala Asp Leu Leu
130 135 140
gat cgc ttt gtc gac gcc acc atc gag cgc atc gat gag cac gat tcc 480
Asp Arg Phe Val Asp Ala Thr Ile Glu Arg Ile Asp Glu His Asp Ser
145 150 155 160
cgc tcc cgc gac atc atg ggc aaa gtg ctt tcc tca cct ggc aca ttc 528
Arg Ser Arg Asp Ile Met Gly Lys Val Leu Ser Ser Pro Gly Thr Phe
165 170 175
tgg gct ggc cgc aac atc cca tcg gtg atc cac agc ctt ggg cat gct 576
Trp Ala Gly Arg Asn Ile Pro Ser Val Ile His Ser Leu Gly His Ala
180 185 190
gac aag tgg tcc cgc tcc gaa ttc gaa gca ttc cat agc cca acc ggc 624
Asp Lys Trp Ser Arg Ser Glu Phe Glu Ala Phe His Ser Pro Thr Gly
195 200 205
gcc aac ttg gtg tac gaa gac gcc gag cac gcg atg ctg act gtg cct 672
Ala Asn Leu Val Tyr Glu Asp Ala Glu His Ala Met Leu Thr Val Pro
210 215 220
ttg gcg ggt tcc acc gca ttc ggc acc acc gct gag ctg aaa atc cgt 720
Leu Ala Gly Ser Thr Ala Phe Gly Thr Thr Ala Glu Leu Lys Ile Arg
225 230 235 240
ttc acc agc ccc atc gac gct ctg cca agc gct gtc cca ctg gtc acc 768
Phe Thr Ser Pro Ile Asp Ala Leu Pro Ser Ala Val Pro Leu Val Thr
245 250 255
cag gaa gac gct gaa gcc gcg atg ggt gaa ctg acc cgc atc gca gct 816
Gln Glu Asp Ala Glu Ala Ala Met Gly Glu Leu Thr Arg Ile Ala Ala
260 265 270
ggc ggc acc ctg gca act gtg aac aat ggc acc gct acc tgg gaa acc 864
Gly Gly Thr Leu Ala Thr Val Asn Asn Gly Thr Ala Thr Trp Glu Thr
275 280 285
tcc gtc gat gcc ggc gtc atc gct gac tac aac aac gtc acc gca ggc 912
Ser Val Asp Ala Gly Val Ile Ala Asp Tyr Asn Asn Val Thr Ala Gly
290 295 300
tac ctg cca gca tcc gtt gtt cct gca cac acc gca cct gac gtg ctg 960
Tyr Leu Pro Ala Ser Val Val Pro Ala His Thr Ala Pro Asp Val Leu
305 310 315 320
gtt ggc cgc gca tgg cca gca gtt ttc gct gcc gta aag tcc gca gtc 1008
Val Gly Arg Ala Trp Pro Ala Val Phe Ala Ala Val Lys Ser Ala Val
325 330 335
atc cca ggc acc gat tcc gca tcc gtt gtg gaa ggc atg ctg tcc ctg 1056
Ile Pro Gly Thr Asp Ser Ala Ser Val Val Glu Gly Met Leu Ser Leu
340 345 350
gtt cac ctg gag cac cac att gtg ctc aag tcc gat gtc cca acc gac 1104
Val His Leu Glu His His Ile Val Leu Lys Ser Asp Val Pro Thr Asp
355 360 365
ggc gcg ctg aag gtt tcc gcg act gcc gat gag gta gtc gat acc gac 1152
Gly Ala Leu Lys Val Ser Ala Thr Ala Asp Glu Val Val Asp Thr Asp
370 375 380
ctg ggt cgc ctc gtg atc gtg cgc gca gaa atc gcc gac gca gaa ggc 1200
Leu Gly Arg Leu Val Ile Val Arg Ala Glu Ile Ala Asp Ala Glu Gly
385 390 395 400
aac ctg att gct acg ttg gct gag cgt ttc gcg atc cgc gga cgc aag 1248
Asn Leu Ile Ala Thr Leu Ala Glu Arg Phe Ala Ile Arg Gly Arg Lys
405 410 415
ggc aac gct gtc gca cgc acc aac acc tcc gca ctg cca acc acc gtg 1296
Gly Asn Ala Val Ala Arg Thr Asn Thr Ser Ala Leu Pro Thr Thr Val
420 425 430
gac acc cca cgc tca gct cgc gca gtg gca acc gtt gtt gca cct gaa 1344
Asp Thr Pro Arg Ser Ala Arg Ala Val Ala Thr Val Val Ala Pro Glu
435 440 445
tcc atg cgc cca ttc gct gtg atc tcc ggt gac cgc aac cca att cac 1392
Ser Met Arg Pro Phe Ala Val Ile Ser Gly Asp Arg Asn Pro Ile His
450 455 460
gtc tct gat gtt gcg gct tcc ctg gct ggt ctg cca ggt gtg atc gtg 1440
Val Ser Asp Val Ala Ala Ser Leu Ala Gly Leu Pro Gly Val Ile Val
465 470 475 480
cac ggc atg tgg acc tct gcc atc ggt gaa ctg atc gcc ggt gca gca 1488
His Gly Met Trp Thr Ser Ala Ile Gly Glu Leu Ile Ala Gly Ala Ala
485 490 495
ttc aac gat gag cag atc caa act ccc gca gcc aag gtc gtg gaa tac 1536
Phe Asn Asp Glu Gln Ile Gln Thr Pro Ala Ala Lys Val Val Glu Tyr
500 505 510
acc gca acc atg ctg gca cca gtt ctt cca ggt gaa gaa att gag ttc 1584
Thr Ala Thr Met Leu Ala Pro Val Leu Pro Gly Glu Glu Ile Glu Phe
515 520 525
agc gtt gag cgc tcc gca gtg gac aac cgc cca gga atg gga gag gtc 1632
Ser Val Glu Arg Ser Ala Val Asp Asn Arg Pro Gly Met Gly Glu Val
530 535 540
cgc acc gtt acc gca acc gtc aac ggc aac tta gtg ctt acc gcc acc 1680
Arg Thr Val Thr Ala Thr Val Asn Gly Asn Leu Val Leu Thr Ala Thr
545 550 555 560
gct gtt gtg gca gct cca tct act ttc tac gca ttc cca ggc cag ggc 1728
Ala Val Val Ala Ala Pro Ser Thr Phe Tyr Ala Phe Pro Gly Gln Gly
565 570 575
att cag tcc cag ggc atg ggt atg gaa gca cgc cgt aac tct cag gca 1776
Ile Gln Ser Gln Gly Met Gly Met Glu Ala Arg Arg Asn Ser Gln Ala
580 585 590
gct cgc gct atc tgg gac cgc gcc gat gca cac acc cgc aat aag ctg 1824
Ala Arg Ala Ile Trp Asp Arg Ala Asp Ala His Thr Arg Asn Lys Leu
595 600 605
ggc ttc tcc atc gtg gaa atc gtg gaa aac aac cca cgc gaa gta acc 1872
Gly Phe Ser Ile Val Glu Ile Val Glu Asn Asn Pro Arg Glu Val Thr
610 615 620
gtg gca ggg gag aag ttc ttc cac cca gac ggc gtt ttg tac ctc acc 1920
Val Ala Gly Glu Lys Phe Phe His Pro Asp Gly Val Leu Tyr Leu Thr
625 630 635 640
cag ttc acc cag gtg ggc atg gca act ctg ggc gtt gct cag atc gct 1968
Gln Phe Thr Gln Val Gly Met Ala Thr Leu Gly Val Ala Gln Ile Ala
645 650 655
gaa atg cgt gaa gca cat gcc ttg aac cag cgt gca tac ttt gct gga 2016
Glu Met Arg Glu Ala His Ala Leu Asn Gln Arg Ala Tyr Phe Ala Gly
660 665 670
cac tcc gtt ggt gag tac aac gcg ctt gct gca tat gct ggt gtg ctg 2064
His Ser Val Gly Glu Tyr Asn Ala Leu Ala Ala Tyr Ala Gly Val Leu
675 680 685
tcc ctg gaa tcc gtt ctg gag atc gtt tac cgt cgt ggc ttg acc atg 2112
Ser Leu Glu Ser Val Leu Glu Ile Val Tyr Arg Arg Gly Leu Thr Met
690 695 700
cac cgc ttg gtg gat cgc gat gaa aac ggt ctg tcc aac tac gcg ctc 2160
His Arg Leu Val Asp Arg Asp Glu Asn Gly Leu Ser Asn Tyr Ala Leu
705 710 715 720
gca gct ctt cgc ccc aac aag atg ggt ctg acc gca gac aac gtt ttc 2208
Ala Ala Leu Arg Pro Asn Lys Met Gly Leu Thr Ala Asp Asn Val Phe
725 730 735
gat tac gtt gcg tct gtt tcc gaa gct tcc ggt gaa ttc ctg gag atc 2256
Asp Tyr Val Ala Ser Val Ser Glu Ala Ser Gly Glu Phe Leu Glu Ile
740 745 750
gtt aac tac aac ttg gct ggc ctg cag tac gca gtt gct gga acc cag 2304
Val Asn Tyr Asn Leu Ala Gly Leu Gln Tyr Ala Val Ala Gly Thr Gln
755 760 765
gct ggt ctt gcc gcc ctt cgt gcc gat gtt gag aac cgt gca cca ggt 2352
Ala Gly Leu Ala Ala Leu Arg Ala Asp Val Glu Asn Arg Ala Pro Gly
770 775 780
cag cgt gcc ttc att ttg atc cct ggc att gac gtg cca ttc cac tcc 2400
Gln Arg Ala Phe Ile Leu Ile Pro Gly Ile Asp Val Pro Phe His Ser
785 790 795 800
tcc aag ctg cgc gac ggt gtg ggc gcg ttc cgt gag cac ctt gat tcc 2448
Ser Lys Leu Arg Asp Gly Val Gly Ala Phe Arg Glu His Leu Asp Ser
805 810 815
ctg atc cca gct gag ctg gat ctg gat gtg ctg gtt ggc cgc tac att 2496
Leu Ile Pro Ala Glu Leu Asp Leu Asp Val Leu Val Gly Arg Tyr Ile
820 825 830
cca aac ttg gtg gct cgc cca ttc gaa ctc act gaa gag ttc gtg gca 2544
Pro Asn Leu Val Ala Arg Pro Phe Glu Leu Thr Glu Glu Phe Val Ala
835 840 845
tcc atg gca gaa gtg gtg gag tcc acc tat gtc aat gag atc ttg gct 2592
Ser Met Ala Glu Val Val Glu Ser Thr Tyr Val Asn Glu Ile Leu Ala
850 855 860
gat ttc aag gct gct tcc gcc gat aag cag aag ctt gcc cgc acg ttg 2640
Asp Phe Lys Ala Ala Ser Ala Asp Lys Gln Lys Leu Ala Arg Thr Leu
865 870 875 880
ctt att gag ctg ctt gca tgg cag ttc gca tca cct gtg cgc tgg atc 2688
Leu Ile Glu Leu Leu Ala Trp Gln Phe Ala Ser Pro Val Arg Trp Ile
885 890 895
gag act cag gat ctg ttg atc aag ggc ctt caa gct gag cgt ttc gtg 2736
Glu Thr Gln Asp Leu Leu Ile Lys Gly Leu Gln Ala Glu Arg Phe Val
900 905 910
gag gtc ggt gtt ggc tct gct cca acg ctt gcc aac atg atg ggc cag 2784
Glu Val Gly Val Gly Ser Ala Pro Thr Leu Ala Asn Met Met Gly Gln
915 920 925
acc ctg cgc ctt cct cag tac gcg gac gcc acc att gag gtg tta aac 2832
Thr Leu Arg Leu Pro Gln Tyr Ala Asp Ala Thr Ile Glu Val Leu Asn
930 935 940
att gag cgc gat cgc cca gtt gtg ttc gct acc gat gag gtt gtg cgt 2880
Ile Glu Arg Asp Arg Pro Val Val Phe Ala Thr Asp Glu Val Val Arg
945 950 955 960
gaa gtg gcg gtt gaa gag acc cca gca gct cct gca gaa acc act gaa 2928
Glu Val Ala Val Glu Glu Thr Pro Ala Ala Pro Ala Glu Thr Thr Glu
965 970 975
acc cca gca acc cca gca acc cca gcc cct gtt gca gct gca gcc cct 2976
Thr Pro Ala Thr Pro Ala Thr Pro Ala Pro Val Ala Ala Ala Ala Pro
980 985 990
gcc acc ggc ggc cct cgc cca gat gac atc agc ttc act cct tct gat 3024
Ala Thr Gly Gly Pro Arg Pro Asp Asp Ile Ser Phe Thr Pro Ser Asp
995 1000 1005
gcc act gaa atg ctc atc gct atc tgg acc aag gtt cgc cca gat cag 3072
Ala Thr Glu Met Leu Ile Ala Ile Trp Thr Lys Val Arg Pro Asp Gln
1010 1015 1020
atg ggt gcc act gat tcc atc gag acc ctg gtt gag ggc gtg tcc tct 3120
Met Gly Ala Thr Asp Ser Ile Glu Thr Leu Val Glu Gly Val Ser Ser
1025 1030 1035 1040
cgc cgt aac cag ctc ctg ctg gat ctt ggt gtg gag ttc ggc ctc ggc 3168
Arg Arg Asn Gln Leu Leu Leu Asp Leu Gly Val Glu Phe Gly Leu Gly
1045 1050 1055
gca att gac gga gca gcc gat gct gag ctc ggt gat cta aag gtc acc 3216
Ala Ile Asp Gly Ala Ala Asp Ala Glu Leu Gly Asp Leu Lys Val Thr
1060 1065 1070
gtg tcc aag atg gct aag ggc tac aag gcg ttt ggc cct gtg ctc tcc 3264
Val Ser Lys Met Ala Lys Gly Tyr Lys Ala Phe Gly Pro Val Leu Ser
1075 1080 1085
gat gct gca gct gat gcc ctg cgt cgc ctc act ggt cct acc ggt aag 3312
Asp Ala Ala Ala Asp Ala Leu Arg Arg Leu Thr Gly Pro Thr Gly Lys
1090 1095 1100
cgc ccg gga tac atc gca gag cgc gtc acc ggc acg tgg gaa ttg ggc 3360
Arg Pro Gly Tyr Ile Ala Glu Arg Val Thr Gly Thr Trp Glu Leu Gly
1105 1110 1115 1120
cag ggc tgg gct gac cac gtg gtc gct gaa gtt gtg atc ggc gcc cgc 3408
Gln Gly Trp Ala Asp His Val Val Ala Glu Val Val Ile Gly Ala Arg
1125 1130 1135
gaa ggc gca tcc ctg cgc ggc ggc gac ctg gcg tca ctg tct cct gca 3456
Glu Gly Ala Ser Leu Arg Gly Gly Asp Leu Ala Ser Leu Ser Pro Ala
1140 1145 1150
agc cca gcg tct gca tca gat ctt gat tcg ctt atc gac gca gcc gtc 3504
Ser Pro Ala Ser Ala Ser Asp Leu Asp Ser Leu Ile Asp Ala Ala Val
1155 1160 1165
cag gcc gta gcc tcc cgc cgc ggc gtt gcg gtc tcc ctg cct tca gca 3552
Gln Ala Val Ala Ser Arg Arg Gly Val Ala Val Ser Leu Pro Ser Ala
1170 1175 1180
ggc ggc gct gcc ggt ggc gtg gtt gat tcc gca gct ctt ggc gag ttt 3600
Gly Gly Ala Ala Gly Gly Val Val Asp Ser Ala Ala Leu Gly Glu Phe
1185 1190 1195 1200
gca gag cag gtc acc gga cac gat ggt gtg ctt gct cag gca gcc cgc 3648
Ala Glu Gln Val Thr Gly His Asp Gly Val Leu Ala Gln Ala Ala Arg
1205 1210 1215
acc atc ttg acc cag ttg ggt ctt gat aag cca gca acc gtt tcc gtg 3696
Thr Ile Leu Thr Gln Leu Gly Leu Asp Lys Pro Ala Thr Val Ser Val
1220 1225 1230
gaa gac acc gca gag gaa gac ctc tac gag ttg gtc tcc aag gaa ctc 3744
Glu Asp Thr Ala Glu Glu Asp Leu Tyr Glu Leu Val Ser Lys Glu Leu
1235 1240 1245
ggt tct gat tgg cca cgt cag gtt gca cca agc ttc gat gaa gaa aag 3792
Gly Ser Asp Trp Pro Arg Gln Val Ala Pro Ser Phe Asp Glu Glu Lys
1250 1255 1260
gtt gtt ctg ctt gat gac cgt tgg gct tct gcg cgt gag 3831
Val Val Leu Leu Asp Asp Arg Trp Ala Ser Ala Arg Glu
1265 1270 1275
<210> 54
<211> 1277
<212> PRT
<213> Corynebacterium glutamicum
<400> 54
Gln Trp Leu Asn Arg Tyr Leu Glu Leu Ser Gly Pro Val Asp Gly Gln
1 5 10 15
Trp Ile Asp Ala Ser Trp Ala Ala Arg Phe Ala Gln Met Leu Glu Arg
20 25 30
Ala Glu Ala Arg Leu Ile Glu Gln Asp His Gly Gln Phe Glu Pro Ser
35 40 45
Leu Thr Val Glu Asp Gly Val Asp Lys Leu Val Ala Ala Tyr Pro His
50 55 60
Ala Ala Thr Asp Leu Leu Thr Pro Ala Asp Val Ala Trp Phe Leu Gly
65 70 75 80
Leu Cys Arg Thr Pro Gly Lys Pro Val Asn Phe Val Pro Val Ile Asp
85 90 95
Lys Asp Val Arg Arg Trp Trp Arg Ser Asp Ser Leu Trp Gln Ser His
100 105 110
Asp Asp Arg Tyr Thr Ala Asp Gln Val Ala Ile Ile Pro Gly Val Val
115 120 125
Ala Val Ala Gly Ile Thr Lys Ala Asn Glu Pro Val Ala Asp Leu Leu
130 135 140
Asp Arg Phe Val Asp Ala Thr Ile Glu Arg Ile Asp Glu His Asp Ser
145 150 155 160
Arg Ser Arg Asp Ile Met Gly Lys Val Leu Ser Ser Pro Gly Thr Phe
165 170 175
Trp Ala Gly Arg Asn Ile Pro Ser Val Ile His Ser Leu Gly His Ala
180 185 190
Asp Lys Trp Ser Arg Ser Glu Phe Glu Ala Phe His Ser Pro Thr Gly
195 200 205
Ala Asn Leu Val Tyr Glu Asp Ala Glu His Ala Met Leu Thr Val Pro
210 215 220
Leu Ala Gly Ser Thr Ala Phe Gly Thr Thr Ala Glu Leu Lys Ile Arg
225 230 235 240
Phe Thr Ser Pro Ile Asp Ala Leu Pro Ser Ala Val Pro Leu Val Thr
245 250 255
Gln Glu Asp Ala Glu Ala Ala Met Gly Glu Leu Thr Arg Ile Ala Ala
260 265 270
Gly Gly Thr Leu Ala Thr Val Asn Asn Gly Thr Ala Thr Trp Glu Thr
275 280 285
Ser Val Asp Ala Gly Val Ile Ala Asp Tyr Asn Asn Val Thr Ala Gly
290 295 300
Tyr Leu Pro Ala Ser Val Val Pro Ala His Thr Ala Pro Asp Val Leu
305 310 315 320
Val Gly Arg Ala Trp Pro Ala Val Phe Ala Ala Val Lys Ser Ala Val
325 330 335
Ile Pro Gly Thr Asp Ser Ala Ser Val Val Glu Gly Met Leu Ser Leu
340 345 350
Val His Leu Glu His His Ile Val Leu Lys Ser Asp Val Pro Thr Asp
355 360 365
Gly Ala Leu Lys Val Ser Ala Thr Ala Asp Glu Val Val Asp Thr Asp
370 375 380
Leu Gly Arg Leu Val Ile Val Arg Ala Glu Ile Ala Asp Ala Glu Gly
385 390 395 400
Asn Leu Ile Ala Thr Leu Ala Glu Arg Phe Ala Ile Arg Gly Arg Lys
405 410 415
Gly Asn Ala Val Ala Arg Thr Asn Thr Ser Ala Leu Pro Thr Thr Val
420 425 430
Asp Thr Pro Arg Ser Ala Arg Ala Val Ala Thr Val Val Ala Pro Glu
435 440 445
Ser Met Arg Pro Phe Ala Val Ile Ser Gly Asp Arg Asn Pro Ile His
450 455 460
Val Ser Asp Val Ala Ala Ser Leu Ala Gly Leu Pro Gly Val Ile Val
465 470 475 480
His Gly Met Trp Thr Ser Ala Ile Gly Glu Leu Ile Ala Gly Ala Ala
485 490 495
Phe Asn Asp Glu Gln Ile Gln Thr Pro Ala Ala Lys Val Val Glu Tyr
500 505 510
Thr Ala Thr Met Leu Ala Pro Val Leu Pro Gly Glu Glu Ile Glu Phe
515 520 525
Ser Val Glu Arg Ser Ala Val Asp Asn Arg Pro Gly Met Gly Glu Val
530 535 540
Arg Thr Val Thr Ala Thr Val Asn Gly Asn Leu Val Leu Thr Ala Thr
545 550 555 560
Ala Val Val Ala Ala Pro Ser Thr Phe Tyr Ala Phe Pro Gly Gln Gly
565 570 575
Ile Gln Ser Gln Gly Met Gly Met Glu Ala Arg Arg Asn Ser Gln Ala
580 585 590
Ala Arg Ala Ile Trp Asp Arg Ala Asp Ala His Thr Arg Asn Lys Leu
595 600 605
Gly Phe Ser Ile Val Glu Ile Val Glu Asn Asn Pro Arg Glu Val Thr
610 615 620
Val Ala Gly Glu Lys Phe Phe His Pro Asp Gly Val Leu Tyr Leu Thr
625 630 635 640
Gln Phe Thr Gln Val Gly Met Ala Thr Leu Gly Val Ala Gln Ile Ala
645 650 655
Glu Met Arg Glu Ala His Ala Leu Asn Gln Arg Ala Tyr Phe Ala Gly
660 665 670
His Ser Val Gly Glu Tyr Asn Ala Leu Ala Ala Tyr Ala Gly Val Leu
675 680 685
Ser Leu Glu Ser Val Leu Glu Ile Val Tyr Arg Arg Gly Leu Thr Met
690 695 700
His Arg Leu Val Asp Arg Asp Glu Asn Gly Leu Ser Asn Tyr Ala Leu
705 710 715 720
Ala Ala Leu Arg Pro Asn Lys Met Gly Leu Thr Ala Asp Asn Val Phe
725 730 735
Asp Tyr Val Ala Ser Val Ser Glu Ala Ser Gly Glu Phe Leu Glu Ile
740 745 750
Val Asn Tyr Asn Leu Ala Gly Leu Gln Tyr Ala Val Ala Gly Thr Gln
755 760 765
Ala Gly Leu Ala Ala Leu Arg Ala Asp Val Glu Asn Arg Ala Pro Gly
770 775 780
Gln Arg Ala Phe Ile Leu Ile Pro Gly Ile Asp Val Pro Phe His Ser
785 790 795 800
Ser Lys Leu Arg Asp Gly Val Gly Ala Phe Arg Glu His Leu Asp Ser
805 810 815
Leu Ile Pro Ala Glu Leu Asp Leu Asp Val Leu Val Gly Arg Tyr Ile
820 825 830
Pro Asn Leu Val Ala Arg Pro Phe Glu Leu Thr Glu Glu Phe Val Ala
835 840 845
Ser Met Ala Glu Val Val Glu Ser Thr Tyr Val Asn Glu Ile Leu Ala
850 855 860
Asp Phe Lys Ala Ala Ser Ala Asp Lys Gln Lys Leu Ala Arg Thr Leu
865 870 875 880
Leu Ile Glu Leu Leu Ala Trp Gln Phe Ala Ser Pro Val Arg Trp Ile
885 890 895
Glu Thr Gln Asp Leu Leu Ile Lys Gly Leu Gln Ala Glu Arg Phe Val
900 905 910
Glu Val Gly Val Gly Ser Ala Pro Thr Leu Ala Asn Met Met Gly Gln
915 920 925
Thr Leu Arg Leu Pro Gln Tyr Ala Asp Ala Thr Ile Glu Val Leu Asn
930 935 940
Ile Glu Arg Asp Arg Pro Val Val Phe Ala Thr Asp Glu Val Val Arg
945 950 955 960
Glu Val Ala Val Glu Glu Thr Pro Ala Ala Pro Ala Glu Thr Thr Glu
965 970 975
Thr Pro Ala Thr Pro Ala Thr Pro Ala Pro Val Ala Ala Ala Ala Pro
980 985 990
Ala Thr Gly Gly Pro Arg Pro Asp Asp Ile Ser Phe Thr Pro Ser Asp
995 1000 1005
Ala Thr Glu Met Leu Ile Ala Ile Trp Thr Lys Val Arg Pro Asp Gln
1010 1015 1020
Met Gly Ala Thr Asp Ser Ile Glu Thr Leu Val Glu Gly Val Ser Ser
1025 1030 1035 1040
Arg Arg Asn Gln Leu Leu Leu Asp Leu Gly Val Glu Phe Gly Leu Gly
1045 1050 1055
Ala Ile Asp Gly Ala Ala Asp Ala Glu Leu Gly Asp Leu Lys Val Thr
1060 1065 1070
Val Ser Lys Met Ala Lys Gly Tyr Lys Ala Phe Gly Pro Val Leu Ser
1075 1080 1085
Asp Ala Ala Ala Asp Ala Leu Arg Arg Leu Thr Gly Pro Thr Gly Lys
1090 1095 1100
Arg Pro Gly Tyr Ile Ala Glu Arg Val Thr Gly Thr Trp Glu Leu Gly
1105 1110 1115 1120
Gln Gly Trp Ala Asp His Val Val Ala Glu Val Val Ile Gly Ala Arg
1125 1130 1135
Glu Gly Ala Ser Leu Arg Gly Gly Asp Leu Ala Ser Leu Ser Pro Ala
1140 1145 1150
Ser Pro Ala Ser Ala Ser Asp Leu Asp Ser Leu Ile Asp Ala Ala Val
1155 1160 1165
Gln Ala Val Ala Ser Arg Arg Gly Val Ala Val Ser Leu Pro Ser Ala
1170 1175 1180
Gly Gly Ala Ala Gly Gly Val Val Asp Ser Ala Ala Leu Gly Glu Phe
1185 1190 1195 1200
Ala Glu Gln Val Thr Gly His Asp Gly Val Leu Ala Gln Ala Ala Arg
1205 1210 1215
Thr Ile Leu Thr Gln Leu Gly Leu Asp Lys Pro Ala Thr Val Ser Val
1220 1225 1230
Glu Asp Thr Ala Glu Glu Asp Leu Tyr Glu Leu Val Ser Lys Glu Leu
1235 1240 1245
Gly Ser Asp Trp Pro Arg Gln Val Ala Pro Ser Phe Asp Glu Glu Lys
1250 1255 1260
Val Val Leu Leu Asp Asp Arg Trp Ala Ser Ala Arg Glu
1265 1270 1275
<210> 55
<211> 4953
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(4930)
<223> RXA02582
<400> 55
tggatgtcta ttctcctcag cctcgttttg gttgaggcgg atagttttaa tattttttta 60
agtttaagtt gtaatcgagc tgaaaggctg aggcctcaat atg gaa cag agc caa 115
Met Glu Gln Ser Gln
1 5
tcg tcg gat cag aag atg acc gtt gaa cag gtt cgc acc tgg ctc cgt 163
Ser Ser Asp Gln Lys Met Thr Val Glu Gln Val Arg Thr Trp Leu Arg
10 15 20
gat tgg gtt gtc cgc acc acg ggt att ccg gtg gag gaa gtt acg gat 211
Asp Trp Val Val Arg Thr Thr Gly Ile Pro Val Glu Glu Val Thr Asp
25 30 35
gac aag gca atg gag acc ttt ggc ctt tcc tct cgc gat gtt gtt gtg 259
Asp Lys Ala Met Glu Thr Phe Gly Leu Ser Ser Arg Asp Val Val Val
40 45 50
ttg tct ggt gag ctg gaa aac ctg ctg gac acc tcc ttg gat gcc acc 307
Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr Ser Leu Asp Ala Thr
55 60 65
atc gct tat gag tac cca acg atc cgt agt ttg gcg cag cgc ctt gtt 355
Ile Ala Tyr Glu Tyr Pro Thr Ile Arg Ser Leu Ala Gln Arg Leu Val
70 75 80 85
gag ggc gag cct cgt cgt gca cat acc cag cgt gaa ttg aat ttc tcc 403
Glu Gly Glu Pro Arg Arg Ala His Thr Gln Arg Glu Leu Asn Phe Ser
90 95 100
gcg gtg agc gat tcc cca ggt tcc cac gat att gcg gtt gtc ggt atg 451
Ala Val Ser Asp Ser Pro Gly Ser His Asp Ile Ala Val Val Gly Met
105 110 115
gct gcg cgt tac cca ggc gct gag agc ctg gag gat atg tgg aag cta 499
Ala Ala Arg Tyr Pro Gly Ala Glu Ser Leu Glu Asp Met Trp Lys Leu
120 125 130
ctc gtc gag ggc cgt gac ggt atc tcg gat cta ccg att ggc cgt tgg 547
Leu Val Glu Gly Arg Asp Gly Ile Ser Asp Leu Pro Ile Gly Arg Trp
135 140 145
tct gag tat gca ggc gat gag gtt atg tct cgg aag atg gaa gag ttt 595
Ser Glu Tyr Ala Gly Asp Glu Val Met Ser Arg Lys Met Glu Glu Phe
150 155 160 165
tct acc atc ggt ggc tac ctg tca gat atc tct agc ttt gat gcg gag 643
Ser Thr Ile Gly Gly Tyr Leu Ser Asp Ile Ser Ser Phe Asp Ala Glu
170 175 180
ttc ttt ggt ctg tct ccg ctc gag gcc gcc aac atg gat cct cag cag 691
Phe Phe Gly Leu Ser Pro Leu Glu Ala Ala Asn Met Asp Pro Gln Gln
185 190 195
cgt att ttg ctg gag cta acg tgg gag gct ttg gag tac gct cgc atc 739
Arg Ile Leu Leu Glu Leu Thr Trp Glu Ala Leu Glu Tyr Ala Arg Ile
200 205 210
gca cca aac act ttg cgt ggc gaa gcc gtg ggc gtg ttc ata ggt tcc 787
Ala Pro Asn Thr Leu Arg Gly Glu Ala Val Gly Val Phe Ile Gly Ser
215 220 225
tcc aac aac gat tac ggc atg atg atc gct gcc gat cca gca gaa gca 835
Ser Asn Asn Asp Tyr Gly Met Met Ile Ala Ala Asp Pro Ala Glu Ala
230 235 240 245
cat cct tat gcg ctg act ggt act tct agt gcg att gtc gct aac cgc 883
His Pro Tyr Ala Leu Thr Gly Thr Ser Ser Ala Ile Val Ala Asn Arg
250 255 260
att aac tac gct ttc gat ttc cgc ggt cct tcc gtc aac gtg gat acc 931
Ile Asn Tyr Ala Phe Asp Phe Arg Gly Pro Ser Val Asn Val Asp Thr
265 270 275
gca tgt tct tct tct ctg gta gcg gtt cac cag gct gtc cgt gcg ctg 979
Ala Cys Ser Ser Ser Leu Val Ala Val His Gln Ala Val Arg Ala Leu
280 285 290
cgt aat ggc gaa gcg gat cac gct atc gct ggt gga gtg aac att ttg 1027
Arg Asn Gly Glu Ala Asp His Ala Ile Ala Gly Gly Val Asn Ile Leu
295 300 305
gca tct cca ttt gtc aca act gca ttc gct gag ctc ggt gtg atc agc 1075
Ala Ser Pro Phe Val Thr Thr Ala Phe Ala Glu Leu Gly Val Ile Ser
310 315 320 325
cca acc ggc aag atc cac gca ttc tct gat gat gcc gat ggt ttc gtg 1123
Pro Thr Gly Lys Ile His Ala Phe Ser Asp Asp Ala Asp Gly Phe Val
330 335 340
cgt tcc gac ggc gcc gga gtc gtt gtg ctg aag cgc gtg gat gac gca 1171
Arg Ser Asp Gly Ala Gly Val Val Val Leu Lys Arg Val Asp Asp Ala
345 350 355
atc cgc gac ggc gac aag atc atc ggt gtg atc aag ggt tct gca gtg 1219
Ile Arg Asp Gly Asp Lys Ile Ile Gly Val Ile Lys Gly Ser Ala Val
360 365 370
aac tcc gat ggt cac tcc aac gga ctg acc gct cca aac cct gac gca 1267
Asn Ser Asp Gly His Ser Asn Gly Leu Thr Ala Pro Asn Pro Asp Ala
375 380 385
cag gtt gat gtg ctg cag cgt gca tat gtt gac gct cag gtt gat ccc 1315
Gln Val Asp Val Leu Gln Arg Ala Tyr Val Asp Ala Gln Val Asp Pro
390 395 400 405
acc acc gtg gat tac gtt gag gct cac ggc acc ggc acc atc ctg ggt 1363
Thr Thr Val Asp Tyr Val Glu Ala His Gly Thr Gly Thr Ile Leu Gly
410 415 420
gac ccc att gaa gca act gcc ctg ggt gct gtt ttg ggc tat ggc cgt 1411
Asp Pro Ile Glu Ala Thr Ala Leu Gly Ala Val Leu Gly Tyr Gly Arg
425 430 435
gac gca tcc acc cca act ctt ctg ggc tct gca aag tcc aac ttc ggc 1459
Asp Ala Ser Thr Pro Thr Leu Leu Gly Ser Ala Lys Ser Asn Phe Gly
440 445 450
cac act gag tca gct gcg ggt att gca ggt gtc atc aag gtg ctg ctt 1507
His Thr Glu Ser Ala Ala Gly Ile Ala Gly Val Ile Lys Val Leu Leu
455 460 465
gct ttg cag aac aag act ctg cca cca acc gtg aac ttt gca ggt cca 1555
Ala Leu Gln Asn Lys Thr Leu Pro Pro Thr Val Asn Phe Ala Gly Pro
470 475 480 485
aac cgc tac atc gat ttc gat gct gag cgt ttg gaa gtt gtg gaa gat 1603
Asn Arg Tyr Ile Asp Phe Asp Ala Glu Arg Leu Glu Val Val Glu Asp
490 495 500
cca cgt gaa tgg ccg gaa tac aac ggt cac gca gta gct ggt gtg tct 1651
Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Ala Val Ala Gly Val Ser
505 510 515
gcg ttc ggg ttc ggt gga acc aac gcg cac gtg gtg atc tct gag tac 1699
Ala Phe Gly Phe Gly Gly Thr Asn Ala His Val Val Ile Ser Glu Tyr
520 525 530
aac gca gaa gac tac gaa acc cgt gcc ccg aag gag gcg ttg ctt cct 1747
Asn Ala Glu Asp Tyr Glu Thr Arg Ala Pro Lys Glu Ala Leu Leu Pro
535 540 545
gac cag cag gtt gcc ctg ccg gtg tct ggt cac ctg cca tcc agg cgt 1795
Asp Gln Gln Val Ala Leu Pro Val Ser Gly His Leu Pro Ser Arg Arg
550 555 560 565
cga caa gca gct gct gac ttg gcg gac ttc ttg gag ggc cgc aaa gat 1843
Arg Gln Ala Ala Ala Asp Leu Ala Asp Phe Leu Glu Gly Arg Lys Asp
570 575 580
tgc gac cta acc cca gta gcc cgc gcg ctg gca ggc cgc aat cat ggc 1891
Cys Asp Leu Thr Pro Val Ala Arg Ala Leu Ala Gly Arg Asn His Gly
585 590 595
cgc tcc cgc gca gtc gtg ctt gca agc act atc gag gaa gcc gta aag 1939
Arg Ser Arg Ala Val Val Leu Ala Ser Thr Ile Glu Glu Ala Val Lys
600 605 610
cgc ctg cgc cag gtc gca gaa ggc aag gtc agc gtc ggt atc tcc gca 1987
Arg Leu Arg Gln Val Ala Glu Gly Lys Val Ser Val Gly Ile Ser Ala
615 620 625
gct gat tcc cca gcg gcc aac ggt cct gtg ttt gtg tac tcc ggt ttc 2035
Ala Asp Ser Pro Ala Ala Asn Gly Pro Val Phe Val Tyr Ser Gly Phe
630 635 640 645
gga tcc cag cac cgc ctc atg atc aag gaa ttg tgc tca att tcg cca 2083
Gly Ser Gln His Arg Leu Met Ile Lys Glu Leu Cys Ser Ile Ser Pro
650 655 660
cag ttc cgc gag cgc atc gaa gag ctc gat gaa atg gtt aag ttc gag 2131
Gln Phe Arg Glu Arg Ile Glu Glu Leu Asp Glu Met Val Lys Phe Glu
665 670 675
tcc ggc tgg tcc atc atg aaa ctt gtt ttg gat gat gag caa act tac 2179
Ser Gly Trp Ser Ile Met Lys Leu Val Leu Asp Asp Glu Gln Thr Tyr
680 685 690
gac acc gag acc gcg cag gtt gtg atc acc gca atc cag atc gca ctg 2227
Asp Thr Glu Thr Ala Gln Val Val Ile Thr Ala Ile Gln Ile Ala Leu
695 700 705
act gac ctg ttg gca agc ttc ggt gta aag cca gct gcc gtc atg ggc 2275
Thr Asp Leu Leu Ala Ser Phe Gly Val Lys Pro Ala Ala Val Met Gly
710 715 720 725
atg tcg atg ggt gag atc gct gcc gct tac gct gcc ggt gga ctc agc 2323
Met Ser Met Gly Glu Ile Ala Ala Ala Tyr Ala Ala Gly Gly Leu Ser
730 735 740
gac cgc gat acc atg ctc att gcc agc cac cgt tcc cgc cta atg ggc 2371
Asp Arg Asp Thr Met Leu Ile Ala Ser His Arg Ser Arg Leu Met Gly
745 750 755
gag ggc gag aag tcc ctg gct gag gat cag ctg ggt gcc atg gct gtg 2419
Glu Gly Glu Lys Ser Leu Ala Glu Asp Gln Leu Gly Ala Met Ala Val
760 765 770
gtg gaa ttc gcc gct gcg gac ctg gat aag ttc atc gaa gaa aac cct 2467
Val Glu Phe Ala Ala Ala Asp Leu Asp Lys Phe Ile Glu Glu Asn Pro
775 780 785
gag tac aag ggc att gag cct gct gtt tat gca ggc cca ggc atg act 2515
Glu Tyr Lys Gly Ile Glu Pro Ala Val Tyr Ala Gly Pro Gly Met Thr
790 795 800 805
acc gtg ggt gga cct cgc gac gcc gtg gtt cag ttc gta gag aag ctg 2563
Thr Val Gly Gly Pro Arg Asp Ala Val Val Gln Phe Val Glu Lys Leu
810 815 820
gaa tct gaa gac aag ttt gcc cgc ctg ctc aac gtc aag ggc gct ggc 2611
Glu Ser Glu Asp Lys Phe Ala Arg Leu Leu Asn Val Lys Gly Ala Gly
825 830 835
cac acc tct gct gtg gaa cca ctt ctt ggt gag ctc gct ggc gaa atc 2659
His Thr Ser Ala Val Glu Pro Leu Leu Gly Glu Leu Ala Gly Glu Ile
840 845 850
gct ggc atc gag cca ctt ccg ctg cag atc ccg ttg ttc agc tct gtc 2707
Ala Gly Ile Glu Pro Leu Pro Leu Gln Ile Pro Leu Phe Ser Ser Val
855 860 865
gat cag ggt gtt acc tac cca gtt gga gca gtg gtc cac gac gcc gat 2755
Asp Gln Gly Val Thr Tyr Pro Val Gly Ala Val Val His Asp Ala Asp
870 875 880 885
tac atg ctc cgc tgt acc cgc cag tcc gtg tac ttc cag gac tcc acc 2803
Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr Phe Gln Asp Ser Thr
890 895 900
gaa gct gca ttc gct gca ggc cac aac acc ttg gtg gaa att tcc ccg 2851
Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu Val Glu Ile Ser Pro
905 910 915
aac cca gtt gca ctc atg ggc atg atg aac acc gcg ttc acc gtg ggc 2899
Asn Pro Val Ala Leu Met Gly Met Met Asn Thr Ala Phe Thr Val Gly
920 925 930
aag cct gat gca cag ctg ctg ttc agc ctg aag cga aaa gtc cca gag 2947
Lys Pro Asp Ala Gln Leu Leu Phe Ser Leu Lys Arg Lys Val Pro Glu
935 940 945
gca gaa tcc ctc cgc gac ctt ctg gcg aag ctg tac gtc aac ggc gca 2995
Ala Glu Ser Leu Arg Asp Leu Leu Ala Lys Leu Tyr Val Asn Gly Ala
950 955 960 965
aac gtt gat ttc tcc gcg ctg tac ggc gaa ggt gaa acc atc gat ccg 3043
Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu Gly Glu Thr Ile Asp Pro
970 975 980
cca cac atc acc tgg aag cac cag cgc ttc tgg act tcc gca cgc cca 3091
Pro His Ile Thr Trp Lys His Gln Arg Phe Trp Thr Ser Ala Arg Pro
985 990 995
tcc tct ggc gca tcc ctg gat ctg ccg ggc ttc cgc gtg aat ctg cca 3139
Ser Ser Gly Ala Ser Leu Asp Leu Pro Gly Phe Arg Val Asn Leu Pro
1000 1005 1010
aac aac act gtg gcg ttt tcc acc gca gcc gaa ctg gca cca tcc gca 3187
Asn Asn Thr Val Ala Phe Ser Thr Ala Ala Glu Leu Ala Pro Ser Ala
1015 1020 1025
gtg gca atc atg gaa gca gcc gcc atg gct gtc acc cca ggt tcc tcc 3235
Val Ala Ile Met Glu Ala Ala Ala Met Ala Val Thr Pro Gly Ser Ser
1030 1035 1040 1045
gtc gac gca gtg gac gag cgc gac atg ctg cca cca agc ggc gaa atc 3283
Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro Pro Ser Gly Glu Ile
1050 1055 1060
acc acc atc gtg act cgc tcc ttg ggc ggt ttg agc ctg tcc gta tac 3331
Thr Thr Ile Val Thr Arg Ser Leu Gly Gly Leu Ser Leu Ser Val Tyr
1065 1070 1075
aag att gag gga acc acc agc act ctt gtc gcc gaa ggt ttc gca gcc 3379
Lys Ile Glu Gly Thr Thr Ser Thr Leu Val Ala Glu Gly Phe Ala Ala
1080 1085 1090
aac cca gga ttc gcc gca gca tct tcc ttc gac ggt cca ggc tac gac 3427
Asn Pro Gly Phe Ala Ala Ala Ser Ser Phe Asp Gly Pro Gly Tyr Asp
1095 1100 1105
gga ttc aac acc gat tac agc gac cag cca gac cct cgc tcc gac ctg 3475
Gly Phe Asn Thr Asp Tyr Ser Asp Gln Pro Asp Pro Arg Ser Asp Leu
1110 1115 1120 1125
cct ttg gac atc gaa gca gtc cgc tgg gac cca gcg acc gaa acc gtc 3523
Pro Leu Asp Ile Glu Ala Val Arg Trp Asp Pro Ala Thr Glu Thr Val
1130 1135 1140
gaa gag cgc atg cgc gcc atc gtc tcc gaa gca atg ggc tac gac gtg 3571
Glu Glu Arg Met Arg Ala Ile Val Ser Glu Ala Met Gly Tyr Asp Val
1145 1150 1155
gat gac ctc cca cgc gaa ctc cca ctg att gac ctc ggc ctc gac tcc 3619
Asp Asp Leu Pro Arg Glu Leu Pro Leu Ile Asp Leu Gly Leu Asp Ser
1160 1165 1170
ctc atg ggc atg cgc atc aaa aac cgc atc gaa aat gac ttc cag atc 3667
Leu Met Gly Met Arg Ile Lys Asn Arg Ile Glu Asn Asp Phe Gln Ile
1175 1180 1185
cca cca ctc cag gtc caa gcg ctc cgc gat gca tcc gtc gct gac gtg 3715
Pro Pro Leu Gln Val Gln Ala Leu Arg Asp Ala Ser Val Ala Asp Val
1190 1195 1200 1205
gta atc atg gtg gaa aac atg gtc gct ggc cgc tcc tct gag acg ctt 3763
Val Ile Met Val Glu Asn Met Val Ala Gly Arg Ser Ser Glu Thr Leu
1210 1215 1220
gtc gac gcc acc ccg cag gtg cca gct gag gca gca ggg gag gct caa 3811
Val Asp Ala Thr Pro Gln Val Pro Ala Glu Ala Ala Gly Glu Ala Gln
1225 1230 1235
gct gct gag tct tct gct tcg ggc gag gac gtg cag ggc gtt ggc gtt 3859
Ala Ala Glu Ser Ser Ala Ser Gly Glu Asp Val Gln Gly Val Gly Val
1240 1245 1250
gca ccg cga gat gcg tcg gaa cgc atg gtc ttt ggt act tgg gca ggc 3907
Ala Pro Arg Asp Ala Ser Glu Arg Met Val Phe Gly Thr Trp Ala Gly
1255 1260 1265
ctg act ggc gct gcg gca gct ggc gtg acc agc aag ttg cca cag atc 3955
Leu Thr Gly Ala Ala Ala Ala Gly Val Thr Ser Lys Leu Pro Gln Ile
1270 1275 1280 1285
gat gtc gat act gca acc gca att gcc gag cgc ctc acc gag cgt tcc 4003
Asp Val Asp Thr Ala Thr Ala Ile Ala Glu Arg Leu Thr Glu Arg Ser
1290 1295 1300
gga att gaa atc agc act gaa cag gtg ttg gct gca gaa acc ctc gaa 4051
Gly Ile Glu Ile Ser Thr Glu Gln Val Leu Ala Ala Glu Thr Leu Glu
1305 1310 1315
cca ctg tct gac ctg gtg cgt gaa ggc ctc gaa act gaa gtt cag ggc 4099
Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu Thr Glu Val Gln Gly
1320 1325 1330
aac att cgt gtg ctg cgt gga cgt gca gaa ggc tcc acc aag cct gca 4147
Asn Ile Arg Val Leu Arg Gly Arg Ala Glu Gly Ser Thr Lys Pro Ala
1335 1340 1345
gtg ttc atg ttc cac cca gct ggc ggt tct tcc gtg gtc tac caa cca 4195
Val Phe Met Phe His Pro Ala Gly Gly Ser Ser Val Val Tyr Gln Pro
1350 1355 1360 1365
cta atg cgt cgt ctg cct gaa gat gtc cct gtc tat ggc gtt gag cgt 4243
Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val Tyr Gly Val Glu Arg
1370 1375 1380
ctg gaa ggc gat ctc gct gac cgc gcg gca gca tat gtt gat gac atc 4291
Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala Tyr Val Asp Asp Ile
1385 1390 1395
aag aag tac tcc gat ggc ttc cca gta gtt ttg ggt ggc tgg agc ttc 4339
Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu Gly Gly Trp Ser Phe
1400 1405 1410
ggc ggt gcc gtt gcc ttc gag gtt gcc cac caa ctg gtt ggc tcc gat 4387
Gly Gly Ala Val Ala Phe Glu Val Ala His Gln Leu Val Gly Ser Asp
1415 1420 1425
gtt gag gta gct acc gtg gcg ttg ctg gat act gtg cag cct tca aac 4435
Val Glu Val Ala Thr Val Ala Leu Leu Asp Thr Val Gln Pro Ser Asn
1430 1435 1440 1445
cca gca cca gat acc gct gag gaa act cgt gca cgc tgg act cgc tac 4483
Pro Ala Pro Asp Thr Ala Glu Glu Thr Arg Ala Arg Trp Thr Arg Tyr
1450 1455 1460
gcg gac ttc gcc aag aag acc tac ggc ctt gat ttc gag gta cct ttt 4531
Ala Asp Phe Ala Lys Lys Thr Tyr Gly Leu Asp Phe Glu Val Pro Phe
1465 1470 1475
gaa atc ttg gac acc atc ggt gaa gac gga atg ctg tcc atg atg acc 4579
Glu Ile Leu Asp Thr Ile Gly Glu Asp Gly Met Leu Ser Met Met Thr
1480 1485 1490
gac ttc ctg gcc aac acc gac gcc tcc gag cac gga ttg tcc gca ggt 4627
Asp Phe Leu Ala Asn Thr Asp Ala Ser Glu His Gly Leu Ser Ala Gly
1495 1500 1505
gtg ctt gaa cac cag cgc gct tct ttt gtg gac aac cgc atc ctg gct 4675
Val Leu Glu His Gln Arg Ala Ser Phe Val Asp Asn Arg Ile Leu Ala
1510 1515 1520 1525
aaa ctt aat ttt gca gac tgg gcc aac gtt gaa gcc cct gtc atc ctg 4723
Lys Leu Asn Phe Ala Asp Trp Ala Asn Val Glu Ala Pro Val Ile Leu
1530 1535 1540
ttc cgc gcg gaa cgc atg cat gat gga gct atc gaa ctt gaa cca aac 4771
Phe Arg Ala Glu Arg Met His Asp Gly Ala Ile Glu Leu Glu Pro Asn
1545 1550 1555
tat gcc aag att gat caa gat gga gga tgg tcc gga att gtc aac gat 4819
Tyr Ala Lys Ile Asp Gln Asp Gly Gly Trp Ser Gly Ile Val Asn Asp
1560 1565 1570
ttg gaa att gtt cag ctg aat ggt gac cac ctg gca gtt gtc gat gaa 4867
Leu Glu Ile Val Gln Leu Asn Gly Asp His Leu Ala Val Val Asp Glu
1575 1580 1585
cca gaa atc ggc aca gtc gga gct cat ttg agt cgc cgc att gat gag 4915
Pro Glu Ile Gly Thr Val Gly Ala His Leu Ser Arg Arg Ile Asp Glu
1590 1595 1600 1605
att tct cgg aag aat tagtaacgga gagctgacgg aag 4953
Ile Ser Arg Lys Asn
1610
<210> 56
<211> 1610
<212> PRT
<213> Corynebacterium glutamicum
<400> 56
Met Glu Gln Ser Gln Ser Ser Asp Gln Lys Met Thr Val Glu Gln Val
1 5 10 15
Arg Thr Trp Leu Arg Asp Trp Val Val Arg Thr Thr Gly Ile Pro Val
20 25 30
Glu Glu Val Thr Asp Asp Lys Ala Met Glu Thr Phe Gly Leu Ser Ser
35 40 45
Arg Asp Val Val Val Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr
50 55 60
Ser Leu Asp Ala Thr Ile Ala Tyr Glu Tyr Pro Thr Ile Arg Ser Leu
65 70 75 80
Ala Gln Arg Leu Val Glu Gly Glu Pro Arg Arg Ala His Thr Gln Arg
85 90 95
Glu Leu Asn Phe Ser Ala Val Ser Asp Ser Pro Gly Ser His Asp Ile
100 105 110
Ala Val Val Gly Met Ala Ala Arg Tyr Pro Gly Ala Glu Ser Leu Glu
115 120 125
Asp Met Trp Lys Leu Leu Val Glu Gly Arg Asp Gly Ile Ser Asp Leu
130 135 140
Pro Ile Gly Arg Trp Ser Glu Tyr Ala Gly Asp Glu Val Met Ser Arg
145 150 155 160
Lys Met Glu Glu Phe Ser Thr Ile Gly Gly Tyr Leu Ser Asp Ile Ser
165 170 175
Ser Phe Asp Ala Glu Phe Phe Gly Leu Ser Pro Leu Glu Ala Ala Asn
180 185 190
Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Leu Thr Trp Glu Ala Leu
195 200 205
Glu Tyr Ala Arg Ile Ala Pro Asn Thr Leu Arg Gly Glu Ala Val Gly
210 215 220
Val Phe Ile Gly Ser Ser Asn Asn Asp Tyr Gly Met Met Ile Ala Ala
225 230 235 240
Asp Pro Ala Glu Ala His Pro Tyr Ala Leu Thr Gly Thr Ser Ser Ala
245 250 255
Ile Val Ala Asn Arg Ile Asn Tyr Ala Phe Asp Phe Arg Gly Pro Ser
260 265 270
Val Asn Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Val His Gln
275 280 285
Ala Val Arg Ala Leu Arg Asn Gly Glu Ala Asp His Ala Ile Ala Gly
290 295 300
Gly Val Asn Ile Leu Ala Ser Pro Phe Val Thr Thr Ala Phe Ala Glu
305 310 315 320
Leu Gly Val Ile Ser Pro Thr Gly Lys Ile His Ala Phe Ser Asp Asp
325 330 335
Ala Asp Gly Phe Val Arg Ser Asp Gly Ala Gly Val Val Val Leu Lys
340 345 350
Arg Val Asp Asp Ala Ile Arg Asp Gly Asp Lys Ile Ile Gly Val Ile
355 360 365
Lys Gly Ser Ala Val Asn Ser Asp Gly His Ser Asn Gly Leu Thr Ala
370 375 380
Pro Asn Pro Asp Ala Gln Val Asp Val Leu Gln Arg Ala Tyr Val Asp
385 390 395 400
Ala Gln Val Asp Pro Thr Thr Val Asp Tyr Val Glu Ala His Gly Thr
405 410 415
Gly Thr Ile Leu Gly Asp Pro Ile Glu Ala Thr Ala Leu Gly Ala Val
420 425 430
Leu Gly Tyr Gly Arg Asp Ala Ser Thr Pro Thr Leu Leu Gly Ser Ala
435 440 445
Lys Ser Asn Phe Gly His Thr Glu Ser Ala Ala Gly Ile Ala Gly Val
450 455 460
Ile Lys Val Leu Leu Ala Leu Gln Asn Lys Thr Leu Pro Pro Thr Val
465 470 475 480
Asn Phe Ala Gly Pro Asn Arg Tyr Ile Asp Phe Asp Ala Glu Arg Leu
485 490 495
Glu Val Val Glu Asp Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Ala
500 505 510
Val Ala Gly Val Ser Ala Phe Gly Phe Gly Gly Thr Asn Ala His Val
515 520 525
Val Ile Ser Glu Tyr Asn Ala Glu Asp Tyr Glu Thr Arg Ala Pro Lys
530 535 540
Glu Ala Leu Leu Pro Asp Gln Gln Val Ala Leu Pro Val Ser Gly His
545 550 555 560
Leu Pro Ser Arg Arg Arg Gln Ala Ala Ala Asp Leu Ala Asp Phe Leu
565 570 575
Glu Gly Arg Lys Asp Cys Asp Leu Thr Pro Val Ala Arg Ala Leu Ala
580 585 590
Gly Arg Asn His Gly Arg Ser Arg Ala Val Val Leu Ala Ser Thr Ile
595 600 605
Glu Glu Ala Val Lys Arg Leu Arg Gln Val Ala Glu Gly Lys Val Ser
610 615 620
Val Gly Ile Ser Ala Ala Asp Ser Pro Ala Ala Asn Gly Pro Val Phe
625 630 635 640
Val Tyr Ser Gly Phe Gly Ser Gln His Arg Leu Met Ile Lys Glu Leu
645 650 655
Cys Ser Ile Ser Pro Gln Phe Arg Glu Arg Ile Glu Glu Leu Asp Glu
660 665 670
Met Val Lys Phe Glu Ser Gly Trp Ser Ile Met Lys Leu Val Leu Asp
675 680 685
Asp Glu Gln Thr Tyr Asp Thr Glu Thr Ala Gln Val Val Ile Thr Ala
690 695 700
Ile Gln Ile Ala Leu Thr Asp Leu Leu Ala Ser Phe Gly Val Lys Pro
705 710 715 720
Ala Ala Val Met Gly Met Ser Met Gly Glu Ile Ala Ala Ala Tyr Ala
725 730 735
Ala Gly Gly Leu Ser Asp Arg Asp Thr Met Leu Ile Ala Ser His Arg
740 745 750
Ser Arg Leu Met Gly Glu Gly Glu Lys Ser Leu Ala Glu Asp Gln Leu
755 760 765
Gly Ala Met Ala Val Val Glu Phe Ala Ala Ala Asp Leu Asp Lys Phe
770 775 780
Ile Glu Glu Asn Pro Glu Tyr Lys Gly Ile Glu Pro Ala Val Tyr Ala
785 790 795 800
Gly Pro Gly Met Thr Thr Val Gly Gly Pro Arg Asp Ala Val Val Gln
805 810 815
Phe Val Glu Lys Leu Glu Ser Glu Asp Lys Phe Ala Arg Leu Leu Asn
820 825 830
Val Lys Gly Ala Gly His Thr Ser Ala Val Glu Pro Leu Leu Gly Glu
835 840 845
Leu Ala Gly Glu Ile Ala Gly Ile Glu Pro Leu Pro Leu Gln Ile Pro
850 855 860
Leu Phe Ser Ser Val Asp Gln Gly Val Thr Tyr Pro Val Gly Ala Val
865 870 875 880
Val His Asp Ala Asp Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr
885 890 895
Phe Gln Asp Ser Thr Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu
900 905 910
Val Glu Ile Ser Pro Asn Pro Val Ala Leu Met Gly Met Met Asn Thr
915 920 925
Ala Phe Thr Val Gly Lys Pro Asp Ala Gln Leu Leu Phe Ser Leu Lys
930 935 940
Arg Lys Val Pro Glu Ala Glu Ser Leu Arg Asp Leu Leu Ala Lys Leu
945 950 955 960
Tyr Val Asn Gly Ala Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu Gly
965 970 975
Glu Thr Ile Asp Pro Pro His Ile Thr Trp Lys His Gln Arg Phe Trp
980 985 990
Thr Ser Ala Arg Pro Ser Ser Gly Ala Ser Leu Asp Leu Pro Gly Phe
995 1000 1005
Arg Val Asn Leu Pro Asn Asn Thr Val Ala Phe Ser Thr Ala Ala Glu
1010 1015 1020
Leu Ala Pro Ser Ala Val Ala Ile Met Glu Ala Ala Ala Met Ala Val
1025 1030 1035 1040
Thr Pro Gly Ser Ser Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro
1045 1050 1055
Pro Ser Gly Glu Ile Thr Thr Ile Val Thr Arg Ser Leu Gly Gly Leu
1060 1065 1070
Ser Leu Ser Val Tyr Lys Ile Glu Gly Thr Thr Ser Thr Leu Val Ala
1075 1080 1085
Glu Gly Phe Ala Ala Asn Pro Gly Phe Ala Ala Ala Ser Ser Phe Asp
1090 1095 1100
Gly Pro Gly Tyr Asp Gly Phe Asn Thr Asp Tyr Ser Asp Gln Pro Asp
1105 1110 1115 1120
Pro Arg Ser Asp Leu Pro Leu Asp Ile Glu Ala Val Arg Trp Asp Pro
1125 1130 1135
Ala Thr Glu Thr Val Glu Glu Arg Met Arg Ala Ile Val Ser Glu Ala
1140 1145 1150
Met Gly Tyr Asp Val Asp Asp Leu Pro Arg Glu Leu Pro Leu Ile Asp
1155 1160 1165
Leu Gly Leu Asp Ser Leu Met Gly Met Arg Ile Lys Asn Arg Ile Glu
1170 1175 1180
Asn Asp Phe Gln Ile Pro Pro Leu Gln Val Gln Ala Leu Arg Asp Ala
1185 1190 1195 1200
Ser Val Ala Asp Val Val Ile Met Val Glu Asn Met Val Ala Gly Arg
1205 1210 1215
Ser Ser Glu Thr Leu Val Asp Ala Thr Pro Gln Val Pro Ala Glu Ala
1220 1225 1230
Ala Gly Glu Ala Gln Ala Ala Glu Ser Ser Ala Ser Gly Glu Asp Val
1235 1240 1245
Gln Gly Val Gly Val Ala Pro Arg Asp Ala Ser Glu Arg Met Val Phe
1250 1255 1260
Gly Thr Trp Ala Gly Leu Thr Gly Ala Ala Ala Ala Gly Val Thr Ser
1265 1270 1275 1280
Lys Leu Pro Gln Ile Asp Val Asp Thr Ala Thr Ala Ile Ala Glu Arg
1285 1290 1295
Leu Thr Glu Arg Ser Gly Ile Glu Ile Ser Thr Glu Gln Val Leu Ala
1300 1305 1310
Ala Glu Thr Leu Glu Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu
1315 1320 1325
Thr Glu Val Gln Gly Asn Ile Arg Val Leu Arg Gly Arg Ala Glu Gly
1330 1335 1340
Ser Thr Lys Pro Ala Val Phe Met Phe His Pro Ala Gly Gly Ser Ser
1345 1350 1355 1360
Val Val Tyr Gln Pro Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val
1365 1370 1375
Tyr Gly Val Glu Arg Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala
1380 1385 1390
Tyr Val Asp Asp Ile Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu
1395 1400 1405
Gly Gly Trp Ser Phe Gly Gly Ala Val Ala Phe Glu Val Ala His Gln
1410 1415 1420
Leu Val Gly Ser Asp Val Glu Val Ala Thr Val Ala Leu Leu Asp Thr
1425 1430 1435 1440
Val Gln Pro Ser Asn Pro Ala Pro Asp Thr Ala Glu Glu Thr Arg Ala
1445 1450 1455
Arg Trp Thr Arg Tyr Ala Asp Phe Ala Lys Lys Thr Tyr Gly Leu Asp
1460 1465 1470
Phe Glu Val Pro Phe Glu Ile Leu Asp Thr Ile Gly Glu Asp Gly Met
1475 1480 1485
Leu Ser Met Met Thr Asp Phe Leu Ala Asn Thr Asp Ala Ser Glu His
1490 1495 1500
Gly Leu Ser Ala Gly Val Leu Glu His Gln Arg Ala Ser Phe Val Asp
1505 1510 1515 1520
Asn Arg Ile Leu Ala Lys Leu Asn Phe Ala Asp Trp Ala Asn Val Glu
1525 1530 1535
Ala Pro Val Ile Leu Phe Arg Ala Glu Arg Met His Asp Gly Ala Ile
1540 1545 1550
Glu Leu Glu Pro Asn Tyr Ala Lys Ile Asp Gln Asp Gly Gly Trp Ser
1555 1560 1565
Gly Ile Val Asn Asp Leu Glu Ile Val Gln Leu Asn Gly Asp His Leu
1570 1575 1580
Ala Val Val Asp Glu Pro Glu Ile Gly Thr Val Gly Ala His Leu Ser
1585 1590 1595 1600
Arg Arg Ile Asp Glu Ile Ser Arg Lys Asn
1605 1610
<210> 57
<211> 930
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(907)
<223> RXA02691
<400> 57
cttagggctt atctgttttc cagccttgct ttttactagg cgctcctgtc ccgcttcagt 60
caccaaaacc acacccctgg ttatgaccag atcggctaaa atg aac acc atg cct 115
Met Asn Thr Met Pro
1 5
gac caa ccg ctc aac cag gac gga ttc cct acc gca tcc aaa ggg gtg 163
Asp Gln Pro Leu Asn Gln Asp Gly Phe Pro Thr Ala Ser Lys Gly Val
10 15 20
gaa ccc gac aac ctc ccc gac cgc gtt ctc gtg gac ggc ctt aaa cca 211
Glu Pro Asp Asn Leu Pro Asp Arg Val Leu Val Asp Gly Leu Lys Pro
25 30 35
aag cat cag cag ctt cgt gaa att ttg gag gaa atc tgc acc acc cag 259
Lys His Gln Gln Leu Arg Glu Ile Leu Glu Glu Ile Cys Thr Thr Gln
40 45 50
ctt cag cct ggg gac atg ctg cct ggt gag cgc atc ctg gaa gaa aag 307
Leu Gln Pro Gly Asp Met Leu Pro Gly Glu Arg Ile Leu Glu Glu Lys
55 60 65
tat ggc gtc agc cga att acg gtt cgt cgg gcg att ggt gat ctg gtc 355
Tyr Gly Val Ser Arg Ile Thr Val Arg Arg Ala Ile Gly Asp Leu Val
70 75 80 85
gcg tcc ggc agg ttg aag cga gct cgc ggc aaa ggt acc ttc gtg gcc 403
Ala Ser Gly Arg Leu Lys Arg Ala Arg Gly Lys Gly Thr Phe Val Ala
90 95 100
cac tcg ccg ttg att tcc cgc ctg cat ttg gcc tcg ttt tcc gca gag 451
His Ser Pro Leu Ile Ser Arg Leu His Leu Ala Ser Phe Ser Ala Glu
105 110 115
atg gcc gcc cag aag cta tcg gct acc agc agg att ttg agt tct tcc 499
Met Ala Ala Gln Lys Leu Ser Ala Thr Ser Arg Ile Leu Ser Ser Ser
120 125 130
cgc ggt ccc gcc cca gat gat att gct gat ttc ttt ggt acc gat cgc 547
Arg Gly Pro Ala Pro Asp Asp Ile Ala Asp Phe Phe Gly Thr Asp Arg
135 140 145
gcg gcc cag cac atc acg ttg cgc cgc ctg cgc ttt gga aat ggt cga 595
Ala Ala Gln His Ile Thr Leu Arg Arg Leu Arg Phe Gly Asn Gly Arg
150 155 160 165
ccc tat gcc att gac aac ggt tgg tac aac tcc gaa ttc gca cct gac 643
Pro Tyr Ala Ile Asp Asn Gly Trp Tyr Asn Ser Glu Phe Ala Pro Asp
170 175 180
ctg ctg gaa aat gat gtg tac aac tcc gtg tac tcc atc ctg gac cgc 691
Leu Leu Glu Asn Asp Val Tyr Asn Ser Val Tyr Ser Ile Leu Asp Arg
185 190 195
gtc tat ggc gtc ccc gtc acc cag gcc gag caa acg gtc acc gcc gta 739
Val Tyr Gly Val Pro Val Thr Gln Ala Glu Gln Thr Val Thr Ala Val
200 205 210
gca gcc gac gaa gac acc gca cgg ctt ctg gac gtc acc ccc ggc gcc 787
Ala Ala Asp Glu Asp Thr Ala Arg Leu Leu Asp Val Thr Pro Gly Ala
215 220 225
cca ctc ctt cgt atc ctt cga cag tca ctt tct ggc gat aag ccc gtg 835
Pro Leu Leu Arg Ile Leu Arg Gln Ser Leu Ser Gly Asp Lys Pro Val
230 235 240 245
gaa tgg tgc gtt tcc ttg tac cga acc gac cga tat tct tta aaa aca 883
Glu Trp Cys Val Ser Leu Tyr Arg Thr Asp Arg Tyr Ser Leu Lys Thr
250 255 260
ttg gtt aca cgc tcc gaa gat ctc tgacgtgaac ccattttggt ggc 930
Leu Val Thr Arg Ser Glu Asp Leu
265
<210> 58
<211> 269
<212> PRT
<213> Corynebacterium glutamicum
<400> 58
Met Asn Thr Met Pro Asp Gln Pro Leu Asn Gln Asp Gly Phe Pro Thr
1 5 10 15
Ala Ser Lys Gly Val Glu Pro Asp Asn Leu Pro Asp Arg Val Leu Val
20 25 30
Asp Gly Leu Lys Pro Lys His Gln Gln Leu Arg Glu Ile Leu Glu Glu
35 40 45
Ile Cys Thr Thr Gln Leu Gln Pro Gly Asp Met Leu Pro Gly Glu Arg
50 55 60
Ile Leu Glu Glu Lys Tyr Gly Val Ser Arg Ile Thr Val Arg Arg Ala
65 70 75 80
Ile Gly Asp Leu Val Ala Ser Gly Arg Leu Lys Arg Ala Arg Gly Lys
85 90 95
Gly Thr Phe Val Ala His Ser Pro Leu Ile Ser Arg Leu His Leu Ala
100 105 110
Ser Phe Ser Ala Glu Met Ala Ala Gln Lys Leu Ser Ala Thr Ser Arg
115 120 125
Ile Leu Ser Ser Ser Arg Gly Pro Ala Pro Asp Asp Ile Ala Asp Phe
130 135 140
Phe Gly Thr Asp Arg Ala Ala Gln His Ile Thr Leu Arg Arg Leu Arg
145 150 155 160
Phe Gly Asn Gly Arg Pro Tyr Ala Ile Asp Asn Gly Trp Tyr Asn Ser
165 170 175
Glu Phe Ala Pro Asp Leu Leu Glu Asn Asp Val Tyr Asn Ser Val Tyr
180 185 190
Ser Ile Leu Asp Arg Val Tyr Gly Val Pro Val Thr Gln Ala Glu Gln
195 200 205
Thr Val Thr Ala Val Ala Ala Asp Glu Asp Thr Ala Arg Leu Leu Asp
210 215 220
Val Thr Pro Gly Ala Pro Leu Leu Arg Ile Leu Arg Gln Ser Leu Ser
225 230 235 240
Gly Asp Lys Pro Val Glu Trp Cys Val Ser Leu Tyr Arg Thr Asp Arg
245 250 255
Tyr Ser Leu Lys Thr Leu Val Thr Arg Ser Glu Asp Leu
260 265
<210> 59
<211> 1968
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1945)
<223> RXA00880
<400> 59
tccatgtggt taaagatatg cctaaagatc tgaccaaaaa cgtgactaaa gacgtgacga 60
cacaagtaca gccaaattaa aggaaaggtt gaatttgacc atg act tca cct aat 115
Met Thr Ser Pro Asn
1 5
acc ctg cag gaa tac act gaa cct gcc aag tac acc atc gga gaa tct 163
Thr Leu Gln Glu Tyr Thr Glu Pro Ala Lys Tyr Thr Ile Gly Glu Ser
10 15 20
gaa acc tgc ctg acc gcc ctt cta gat cag att aag act cga cct tac 211
Glu Thr Cys Leu Thr Ala Leu Leu Asp Gln Ile Lys Thr Arg Pro Tyr
25 30 35
gga gtt ttg ttc agc aag cct gcc aac tat gag tgg gtg aat gta act 259
Gly Val Leu Phe Ser Lys Pro Ala Asn Tyr Glu Trp Val Asn Val Thr
40 45 50
gcc aaa gaa ttt cag gac gag gtt ttt gcg gtt gca aaa gga att att 307
Ala Lys Glu Phe Gln Asp Glu Val Phe Ala Val Ala Lys Gly Ile Ile
55 60 65
tca gtc ggc gta gag cag gga gac cgt gtc gcg ctg ctg tcc aat act 355
Ser Val Gly Val Glu Gln Gly Asp Arg Val Ala Leu Leu Ser Asn Thr
70 75 80 85
cgc tat gag tgg gct gtg ctt gat ttc gct atc tgg gcc gct ggc gca 403
Arg Tyr Glu Trp Ala Val Leu Asp Phe Ala Ile Trp Ala Ala Gly Ala
90 95 100
gtg agc gtg cct atc tac agc tcc tct tca ctg tcc caa att gag tgg 451
Val Ser Val Pro Ile Tyr Ser Ser Ser Ser Leu Ser Gln Ile Glu Trp
105 110 115
atc att gag gat tcc ggc gct gtt ttg gcc att acc gaa acc cct gat 499
Ile Ile Glu Asp Ser Gly Ala Val Leu Ala Ile Thr Glu Thr Pro Asp
120 125 130
cat acc gac ttg atg aag aac ctg gtc atc ggt gaa gac gga act cca 547
His Thr Asp Leu Met Lys Asn Leu Val Ile Gly Glu Asp Gly Thr Pro
135 140 145
gcg att aag ggt tca cct tcc aag ctg cgc cgc att cta gag atc aac 595
Ala Ile Lys Gly Ser Pro Ser Lys Leu Arg Arg Ile Leu Glu Ile Asn
150 155 160 165
tct tcg gcg ttg gag acc ttg aag ttt gag ggc cgc gag ctt tct gat 643
Ser Ser Ala Leu Glu Thr Leu Lys Phe Glu Gly Arg Glu Leu Ser Asp
170 175 180
gag ctg gtg tgg gaa cgc att cat gca acc aag gcc gct gac ctg gcg 691
Glu Leu Val Trp Glu Arg Ile His Ala Thr Lys Ala Ala Asp Leu Ala
185 190 195
tct ttg gtg tac acc tct ggc aca act ggt agg ccg aag ggc tgc gag 739
Ser Leu Val Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Cys Glu
200 205 210
ttg tcc cac tac cac tgg ttg gct gag gtc cga gcg ctg atc acc aat 787
Leu Ser His Tyr His Trp Leu Ala Glu Val Arg Ala Leu Ile Thr Asn
215 220 225
gac atc gga gcg atc gcg atg cca ggt tca agg ttg ctc acc ttc ctt 835
Asp Ile Gly Ala Ile Ala Met Pro Gly Ser Arg Leu Leu Thr Phe Leu
230 235 240 245
cct ttg gcg cac gtt ctt gct cgc gca gtg cac ttg gcc ttc gct gtc 883
Pro Leu Ala His Val Leu Ala Arg Ala Val His Leu Ala Phe Ala Val
250 255 260
acc ggt gca acc cag tcc cac tgg tct gat ttc agc acc ctt act ttg 931
Thr Gly Ala Thr Gln Ser His Trp Ser Asp Phe Ser Thr Leu Thr Leu
265 270 275
gaa ctg cag cgt tcc cgc ccg aac ctg att ttg ggt gtt cca cgc gtg 979
Glu Leu Gln Arg Ser Arg Pro Asn Leu Ile Leu Gly Val Pro Arg Val
280 285 290
ttt gaa aag gtc cgc aac gcc gct gct gct aat gct gct gac ggt ggc 1027
Phe Glu Lys Val Arg Asn Ala Ala Ala Ala Asn Ala Ala Asp Gly Gly
295 300 305
gca atc aag cgc atc atg ttt gag cgt gcc gaa aag gcg gcc att gaa 1075
Ala Ile Lys Arg Ile Met Phe Glu Arg Ala Glu Lys Ala Ala Ile Glu
310 315 320 325
tac tcc atg gct ctt gat act gca gaa ggc cca agc aag tcc cag gtt 1123
Tyr Ser Met Ala Leu Asp Thr Ala Glu Gly Pro Ser Lys Ser Gln Val
330 335 340
atg gca cat aaa gcg ttt gac aag ctg gtg tac tcc aag atc cgt gca 1171
Met Ala His Lys Ala Phe Asp Lys Leu Val Tyr Ser Lys Ile Arg Ala
345 350 355
gct gtc ggt ggc gat gtg cag tac gcc atc acc ggt ggt tca gcg atg 1219
Ala Val Gly Gly Asp Val Gln Tyr Ala Ile Thr Gly Gly Ser Ala Met
360 365 370
ggg cag gag ctg ctg cac ttc ttc cgc ggt gtg ggc atg acc atc tac 1267
Gly Gln Glu Leu Leu His Phe Phe Arg Gly Val Gly Met Thr Ile Tyr
375 380 385
gaa ggt tat ggt ctg acg gaa tct gcg gct gct gca gcg gtg gac ttc 1315
Glu Gly Tyr Gly Leu Thr Glu Ser Ala Ala Ala Ala Ala Val Asp Phe
390 395 400 405
act gat caa aag atc ggc act gtg ggt aag ccg atg ggt ggc atg acc 1363
Thr Asp Gln Lys Ile Gly Thr Val Gly Lys Pro Met Gly Gly Met Thr
410 415 420
atc aag atc aat gaa gat ggc gaa atc atg cta aaa ggc gag atg ttg 1411
Ile Lys Ile Asn Glu Asp Gly Glu Ile Met Leu Lys Gly Glu Met Leu
425 430 435
ttc cag gga tat tgg aac aac cca gaa gcc aca gca gaa gcc ctc cac 1459
Phe Gln Gly Tyr Trp Asn Asn Pro Glu Ala Thr Ala Glu Ala Leu His
440 445 450
gac ggt tgg ttc aac acc ggc gat ctg ggt gag ctg ttg gag tct gga 1507
Asp Gly Trp Phe Asn Thr Gly Asp Leu Gly Glu Leu Leu Glu Ser Gly
455 460 465
cac ctg gtg atc acc gga cgt aag aaa gat ctg atc gtg acc gcg ggc 1555
His Leu Val Ile Thr Gly Arg Lys Lys Asp Leu Ile Val Thr Ala Gly
470 475 480 485
ggc aag aac gtt tcc cca gga ccc atg gaa gac atc atc cgc gca cac 1603
Gly Lys Asn Val Ser Pro Gly Pro Met Glu Asp Ile Ile Arg Ala His
490 495 500
cca ctg gtc agc cag gcc atg gtg gtg ggc gat ggt aaa cca ttc gtt 1651
Pro Leu Val Ser Gln Ala Met Val Val Gly Asp Gly Lys Pro Phe Val
505 510 515
ggc ctg ctg gtg acc ttg gat cca gat atg ttg aag cgg tgg aag ctg 1699
Gly Leu Leu Val Thr Leu Asp Pro Asp Met Leu Lys Arg Trp Lys Leu
520 525 530
aac cac aac att gcg gaa tcc cgc acg gtt tct gag att gct act gat 1747
Asn His Asn Ile Ala Glu Ser Arg Thr Val Ser Glu Ile Ala Thr Asp
535 540 545
cct gca ctg cgt gcg gaa atc cag gat gca gtc aac aac gct aat gcc 1795
Pro Ala Leu Arg Ala Glu Ile Gln Asp Ala Val Asn Asn Ala Asn Ala
550 555 560 565
acg gtg tct cat tca gag gcg atc aag cgg ttc tac atc ctt gat cgc 1843
Thr Val Ser His Ser Glu Ala Ile Lys Arg Phe Tyr Ile Leu Asp Arg
570 575 580
gac ctg acc gag gaa gcc gac gag ctg acc cca acg ctg aag gtc aag 1891
Asp Leu Thr Glu Glu Ala Asp Glu Leu Thr Pro Thr Leu Lys Val Lys
585 590 595
cgc aac gtt gtt gtt cgc cgt tac gca gac gcc atc gac cac atc tac 1939
Arg Asn Val Val Val Arg Arg Tyr Ala Asp Ala Ile Asp His Ile Tyr
600 605 610
aac cga tgagtaacac agagacccaa ttt 1968
Asn Arg
615
<210> 60
<211> 615
<212> PRT
<213> Corynebacterium glutamicum
<400> 60
Met Thr Ser Pro Asn Thr Leu Gln Glu Tyr Thr Glu Pro Ala Lys Tyr
1 5 10 15
Thr Ile Gly Glu Ser Glu Thr Cys Leu Thr Ala Leu Leu Asp Gln Ile
20 25 30
Lys Thr Arg Pro Tyr Gly Val Leu Phe Ser Lys Pro Ala Asn Tyr Glu
35 40 45
Trp Val Asn Val Thr Ala Lys Glu Phe Gln Asp Glu Val Phe Ala Val
50 55 60
Ala Lys Gly Ile Ile Ser Val Gly Val Glu Gln Gly Asp Arg Val Ala
65 70 75 80
Leu Leu Ser Asn Thr Arg Tyr Glu Trp Ala Val Leu Asp Phe Ala Ile
85 90 95
Trp Ala Ala Gly Ala Val Ser Val Pro Ile Tyr Ser Ser Ser Ser Leu
100 105 110
Ser Gln Ile Glu Trp Ile Ile Glu Asp Ser Gly Ala Val Leu Ala Ile
115 120 125
Thr Glu Thr Pro Asp His Thr Asp Leu Met Lys Asn Leu Val Ile Gly
130 135 140
Glu Asp Gly Thr Pro Ala Ile Lys Gly Ser Pro Ser Lys Leu Arg Arg
145 150 155 160
Ile Leu Glu Ile Asn Ser Ser Ala Leu Glu Thr Leu Lys Phe Glu Gly
165 170 175
Arg Glu Leu Ser Asp Glu Leu Val Trp Glu Arg Ile His Ala Thr Lys
180 185 190
Ala Ala Asp Leu Ala Ser Leu Val Tyr Thr Ser Gly Thr Thr Gly Arg
195 200 205
Pro Lys Gly Cys Glu Leu Ser His Tyr His Trp Leu Ala Glu Val Arg
210 215 220
Ala Leu Ile Thr Asn Asp Ile Gly Ala Ile Ala Met Pro Gly Ser Arg
225 230 235 240
Leu Leu Thr Phe Leu Pro Leu Ala His Val Leu Ala Arg Ala Val His
245 250 255
Leu Ala Phe Ala Val Thr Gly Ala Thr Gln Ser His Trp Ser Asp Phe
260 265 270
Ser Thr Leu Thr Leu Glu Leu Gln Arg Ser Arg Pro Asn Leu Ile Leu
275 280 285
Gly Val Pro Arg Val Phe Glu Lys Val Arg Asn Ala Ala Ala Ala Asn
290 295 300
Ala Ala Asp Gly Gly Ala Ile Lys Arg Ile Met Phe Glu Arg Ala Glu
305 310 315 320
Lys Ala Ala Ile Glu Tyr Ser Met Ala Leu Asp Thr Ala Glu Gly Pro
325 330 335
Ser Lys Ser Gln Val Met Ala His Lys Ala Phe Asp Lys Leu Val Tyr
340 345 350
Ser Lys Ile Arg Ala Ala Val Gly Gly Asp Val Gln Tyr Ala Ile Thr
355 360 365
Gly Gly Ser Ala Met Gly Gln Glu Leu Leu His Phe Phe Arg Gly Val
370 375 380
Gly Met Thr Ile Tyr Glu Gly Tyr Gly Leu Thr Glu Ser Ala Ala Ala
385 390 395 400
Ala Ala Val Asp Phe Thr Asp Gln Lys Ile Gly Thr Val Gly Lys Pro
405 410 415
Met Gly Gly Met Thr Ile Lys Ile Asn Glu Asp Gly Glu Ile Met Leu
420 425 430
Lys Gly Glu Met Leu Phe Gln Gly Tyr Trp Asn Asn Pro Glu Ala Thr
435 440 445
Ala Glu Ala Leu His Asp Gly Trp Phe Asn Thr Gly Asp Leu Gly Glu
450 455 460
Leu Leu Glu Ser Gly His Leu Val Ile Thr Gly Arg Lys Lys Asp Leu
465 470 475 480
Ile Val Thr Ala Gly Gly Lys Asn Val Ser Pro Gly Pro Met Glu Asp
485 490 495
Ile Ile Arg Ala His Pro Leu Val Ser Gln Ala Met Val Val Gly Asp
500 505 510
Gly Lys Pro Phe Val Gly Leu Leu Val Thr Leu Asp Pro Asp Met Leu
515 520 525
Lys Arg Trp Lys Leu Asn His Asn Ile Ala Glu Ser Arg Thr Val Ser
530 535 540
Glu Ile Ala Thr Asp Pro Ala Leu Arg Ala Glu Ile Gln Asp Ala Val
545 550 555 560
Asn Asn Ala Asn Ala Thr Val Ser His Ser Glu Ala Ile Lys Arg Phe
565 570 575
Tyr Ile Leu Asp Arg Asp Leu Thr Glu Glu Ala Asp Glu Leu Thr Pro
580 585 590
Thr Leu Lys Val Lys Arg Asn Val Val Val Arg Arg Tyr Ala Asp Ala
595 600 605
Ile Asp His Ile Tyr Asn Arg
610 615
<210> 61
<211> 1047
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1024)
<223> RXA01060
<400> 61
ttccatttac acatctgttc gactcgcgcc cgaatgatgt cgcatcaaca tgagaagcta 60
cttccatact tttactgatt gataagaatg gacaaagaca atg aac cgc aca ctc 115
Met Asn Arg Thr Leu
1 5
cga aca ctt ggc tgg ctt gct gcc gta att caa gaa gat ccg gag ccc 163
Arg Thr Leu Gly Trp Leu Ala Ala Val Ile Gln Glu Asp Pro Glu Pro
10 15 20
tgg ttc acc act gat ccc gac acc gat tat gtc cct tat gta aat agt 211
Trp Phe Thr Thr Asp Pro Asp Thr Asp Tyr Val Pro Tyr Val Asn Ser
25 30 35
ttc tca ttt gaa tcc ctt tcc ctc gtt cca gat gct ctg atg ctg ctc 259
Phe Ser Phe Glu Ser Leu Ser Leu Val Pro Asp Ala Leu Met Leu Leu
40 45 50
aaa cgt tct ctt cac ctt gcg atg gag caa cag gac ctc cca gtg aag 307
Lys Arg Ser Leu His Leu Ala Met Glu Gln Gln Asp Leu Pro Val Lys
55 60 65
gat cta caa gaa gca ctg agg cac gta cta gtt ttc aaa ttc cac ttc 355
Asp Leu Gln Glu Ala Leu Arg His Val Leu Val Phe Lys Phe His Phe
70 75 80 85
agg gaa gaa tgg gag ctg gaa tta gca tgg gac tcc gag cgg acc aag 403
Arg Glu Glu Trp Glu Leu Glu Leu Ala Trp Asp Ser Glu Arg Thr Lys
90 95 100
tct gcg gtg aga att att gag agc aca aaa gaa tct ctt gcc gat caa 451
Ser Ala Val Arg Ile Ile Glu Ser Thr Lys Glu Ser Leu Ala Asp Gln
105 110 115
tac aga gat tac aaa tac gca ttc ttg cct gag cta att ttc cag gaa 499
Tyr Arg Asp Tyr Lys Tyr Ala Phe Leu Pro Glu Leu Ile Phe Gln Glu
120 125 130
tca cgc ggg atc ttt gac ttt gag ctg gag gga tac acc ctc aaa gta 547
Ser Arg Gly Ile Phe Asp Phe Glu Leu Glu Gly Tyr Thr Leu Lys Val
135 140 145
gga caa agc acg ctt tcc att cct tgg gac atg atc gcc aat ggt tat 595
Gly Gln Ser Thr Leu Ser Ile Pro Trp Asp Met Ile Ala Asn Gly Tyr
150 155 160 165
gtc cct gca agt ctt cgg aat ttt gga gaa tta atg gac cgt gac acc 643
Val Pro Ala Ser Leu Arg Asn Phe Gly Glu Leu Met Asp Arg Asp Thr
170 175 180
gga gat ctt gat gca gat ccc att ctg aga cct cga gaa ctc aaa ttt 691
Gly Asp Leu Asp Ala Asp Pro Ile Leu Arg Pro Arg Glu Leu Lys Phe
185 190 195
gag atc cat aat tgt cca gat ctt aat cct tgg ata atg cgg gaa act 739
Glu Ile His Asn Cys Pro Asp Leu Asn Pro Trp Ile Met Arg Glu Thr
200 205 210
ttt gat ttc atg atg gaa atc gca act gaa aca gga tgg ttc cat gct 787
Phe Asp Phe Met Met Glu Ile Ala Thr Glu Thr Gly Trp Phe His Ala
215 220 225
ctc aac ccc gca tat aat tcc gtc tac acc tac gat ctt att tct cgc 835
Leu Asn Pro Ala Tyr Asn Ser Val Tyr Thr Tyr Asp Leu Ile Ser Arg
230 235 240 245
atg cca gat ttc ctt gtt gaa ggg agc ttt cgt ccg cat tca gtg aaa 883
Met Pro Asp Phe Leu Val Glu Gly Ser Phe Arg Pro His Ser Val Lys
250 255 260
cga tct tgg gaa aaa att caa aag ata gct aaa gct gtt gag tct tat 931
Arg Ser Trp Glu Lys Ile Gln Lys Ile Ala Lys Ala Val Glu Ser Tyr
265 270 275
gca tct cac gat tac tgc atg tca acg ctg aca cat gac tac agg gca 979
Ala Ser His Asp Tyr Cys Met Ser Thr Leu Thr His Asp Tyr Arg Ala
280 285 290
atc gag tta tcc ctg acg cct aca aaa act gag gaa cca agc aca 1024
Ile Glu Leu Ser Leu Thr Pro Thr Lys Thr Glu Glu Pro Ser Thr
295 300 305
taagaaaacc tcgcctgccc act 1047
<210> 62
<211> 308
<212> PRT
<213> Corynebacterium glutamicum
<400> 62
Met Asn Arg Thr Leu Arg Thr Leu Gly Trp Leu Ala Ala Val Ile Gln
1 5 10 15
Glu Asp Pro Glu Pro Trp Phe Thr Thr Asp Pro Asp Thr Asp Tyr Val
20 25 30
Pro Tyr Val Asn Ser Phe Ser Phe Glu Ser Leu Ser Leu Val Pro Asp
35 40 45
Ala Leu Met Leu Leu Lys Arg Ser Leu His Leu Ala Met Glu Gln Gln
50 55 60
Asp Leu Pro Val Lys Asp Leu Gln Glu Ala Leu Arg His Val Leu Val
65 70 75 80
Phe Lys Phe His Phe Arg Glu Glu Trp Glu Leu Glu Leu Ala Trp Asp
85 90 95
Ser Glu Arg Thr Lys Ser Ala Val Arg Ile Ile Glu Ser Thr Lys Glu
100 105 110
Ser Leu Ala Asp Gln Tyr Arg Asp Tyr Lys Tyr Ala Phe Leu Pro Glu
115 120 125
Leu Ile Phe Gln Glu Ser Arg Gly Ile Phe Asp Phe Glu Leu Glu Gly
130 135 140
Tyr Thr Leu Lys Val Gly Gln Ser Thr Leu Ser Ile Pro Trp Asp Met
145 150 155 160
Ile Ala Asn Gly Tyr Val Pro Ala Ser Leu Arg Asn Phe Gly Glu Leu
165 170 175
Met Asp Arg Asp Thr Gly Asp Leu Asp Ala Asp Pro Ile Leu Arg Pro
180 185 190
Arg Glu Leu Lys Phe Glu Ile His Asn Cys Pro Asp Leu Asn Pro Trp
195 200 205
Ile Met Arg Glu Thr Phe Asp Phe Met Met Glu Ile Ala Thr Glu Thr
210 215 220
Gly Trp Phe His Ala Leu Asn Pro Ala Tyr Asn Ser Val Tyr Thr Tyr
225 230 235 240
Asp Leu Ile Ser Arg Met Pro Asp Phe Leu Val Glu Gly Ser Phe Arg
245 250 255
Pro His Ser Val Lys Arg Ser Trp Glu Lys Ile Gln Lys Ile Ala Lys
260 265 270
Ala Val Glu Ser Tyr Ala Ser His Asp Tyr Cys Met Ser Thr Leu Thr
275 280 285
His Asp Tyr Arg Ala Ile Glu Leu Ser Leu Thr Pro Thr Lys Thr Glu
290 295 300
Glu Pro Ser Thr
305
<210> 63
<211> 1848
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1825)
<223> RXN01722
<400> 63
ctcattcccc tcgctaaaag ctgcataaag tttcgacgtt ttcaaagttg attgcttgca 60
ctgtcgttgc gtgtcgcatg ccccggctat tgttgattgc atg ctc agc acg atg 115
Met Leu Ser Thr Met
1 5
cag gac gtc cca ctg tca tta acc aga atc ctc gag tac ggg tcc act 163
Gln Asp Val Pro Leu Ser Leu Thr Arg Ile Leu Glu Tyr Gly Ser Thr
10 15 20
gtt cac ggt gat act ttg atc acc acg tgg ggc ggt gcc gat ggc att 211
Val His Gly Asp Thr Leu Ile Thr Thr Trp Gly Gly Ala Asp Gly Ile
25 30 35
gaa caa gca cag caa act ttt agt gct gtg ggg gct aga gct gcg gct 259
Glu Gln Ala Gln Gln Thr Phe Ser Ala Val Gly Ala Arg Ala Ala Ala
40 45 50
ttg gct cat gcg ctg cat gat tct tta ggt att act ggg gat cag cga 307
Leu Ala His Ala Leu His Asp Ser Leu Gly Ile Thr Gly Asp Gln Arg
55 60 65
gtg gcg tcg atg ctc tat aac tgc gcg gaa cac atg gaa act atg ttt 355
Val Ala Ser Met Leu Tyr Asn Cys Ala Glu His Met Glu Thr Met Phe
70 75 80 85
gca gtc gca tgc atg ggt gcc gtg ttt aat ccg ctg aac aag cag ttg 403
Ala Val Ala Cys Met Gly Ala Val Phe Asn Pro Leu Asn Lys Gln Leu
90 95 100
atg aat gat cag att gtg ttc att ctc aat cac tct gaa gct gaa gtg 451
Met Asn Asp Gln Ile Val Phe Ile Leu Asn His Ser Glu Ala Glu Val
105 110 115
gtt atc gct gat ccg cgc atg gct gaa caa ttg ggt gag atc tta aaa 499
Val Ile Ala Asp Pro Arg Met Ala Glu Gln Leu Gly Glu Ile Leu Lys
120 125 130
gaa aca cca aaa gtt cgt gcc gtg gtg ttt att gga ccg aat gat ttc 547
Glu Thr Pro Lys Val Arg Ala Val Val Phe Ile Gly Pro Asn Asp Phe
135 140 145
tct agc gcg gcg gcc cac atg ccg gag gga atg aag ctg tat tcc tat 595
Ser Ser Ala Ala Ala His Met Pro Glu Gly Met Lys Leu Tyr Ser Tyr
150 155 160 165
gaa gcg ctc ctt gac ggc cgt tcc act gtt tac aac tgg ccc gag cag 643
Glu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr Asn Trp Pro Glu Gln
170 175 180
gat gaa cgc act gct gct gca att tgc tat tcc acc ggt aca tcg gga 691
Asp Glu Arg Thr Ala Ala Ala Ile Cys Tyr Ser Thr Gly Thr Ser Gly
185 190 195
ccg ccg aag ggt gtg gtg tat tcc cac cgc tcg ctt tat tta cag tcg 739
Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser Leu Tyr Leu Gln Ser
200 205 210
ttg agc ttg cgc acc acg gat tcc ctc gca gtg gaa cac ggc gaa acg 787
Leu Ser Leu Arg Thr Thr Asp Ser Leu Ala Val Glu His Gly Glu Thr
215 220 225
ttc ctg tgc tgt gtg ccg att tac cac gtc ctc agc tgg ggc gtg ccg 835
Phe Leu Cys Cys Val Pro Ile Tyr His Val Leu Ser Trp Gly Val Pro
230 235 240 245
atc gca gcg ttt atg tcc ggc act ccc ctg gtg ctt cct gga ccg gat 883
Ile Ala Ala Phe Met Ser Gly Thr Pro Leu Val Leu Pro Gly Pro Asp
250 255 260
ctt tct gcg ccg aca ttg gca aag atc att tcc acc acg ctg cct cgc 931
Leu Ser Ala Pro Thr Leu Ala Lys Ile Ile Ser Thr Thr Leu Pro Arg
265 270 275
gtg gcg cat ggc gtg cct act ctc tgg att cag ctg atg gtt cac tac 979
Val Ala His Gly Val Pro Thr Leu Trp Ile Gln Leu Met Val His Tyr
280 285 290
ctg aaa aat ccc cca gag cgt atg tct ctg cgt gag cta tac gtg ggc 1027
Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg Glu Leu Tyr Val Gly
295 300 305
ggt tct gcg gtg cct cca atc gtg atc acc atg tgg gag cag cgc tat 1075
Gly Ser Ala Val Pro Pro Ile Val Ile Thr Met Trp Glu Gln Arg Tyr
310 315 320 325
ggc gtg gat gtt gtc cac gtg tgg ggt atg acg gaa acc tcc acc gtg 1123
Gly Val Asp Val Val His Val Trp Gly Met Thr Glu Thr Ser Thr Val
330 335 340
ggt act gtg tct cgc cca cca tca ggt gtt tct ggt gaa agc cgg tgg 1171
Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser Gly Glu Ser Arg Trp
345 350 355
aat tat cga gtc tcc cag ggc cga ttc ccc gcc tcc ctg cag tac cgc 1219
Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Ala Ser Leu Gln Tyr Arg
360 365 370
att gtc aac gac ggc cag gtc atg gcg tcc acc gac cgc aac gag ggc 1267
Ile Val Asn Asp Gly Gln Val Met Ala Ser Thr Asp Arg Asn Glu Gly
375 380 385
gag att cag gtc cgc ggt ccg tgg gtg act gca agt tac ttc cac ccc 1315
Glu Ile Gln Val Arg Gly Pro Trp Val Thr Ala Ser Tyr Phe His Pro
390 395 400 405
gat gtg gaa aaa gaa ggt ggc acc gcc tca aca ttc cgc gac cat gac 1363
Asp Val Glu Lys Glu Gly Gly Thr Ala Ser Thr Phe Arg Asp His Asp
410 415 420
gtt gaa gag gaa aac gat gag ctc ttc acc gcc gac ggc tgg ctg cgc 1411
Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Ala Asp Gly Trp Leu Arg
425 430 435
acc ggg gac gtt gga tct gtc acc agc gat gga ttc ctc acc atc caa 1459
Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly Phe Leu Thr Ile Gln
440 445 450
gac cgc gcc cgc gat gtc atc cgt tct ggc ggc gag tgg att tac tcc 1507
Asp Arg Ala Arg Asp Val Ile Arg Ser Gly Gly Glu Trp Ile Tyr Ser
455 460 465
gct cag ctg gaa aac ctc atc gtg gct acg gaa gag gtt gtc gaa tgc 1555
Ala Gln Leu Glu Asn Leu Ile Val Ala Thr Glu Glu Val Val Glu Cys
470 475 480 485
gcc gtc att ggc ttc ccc gat gac aag tgg gtg gaa cgt ccc ctc gca 1603
Ala Val Ile Gly Phe Pro Asp Asp Lys Trp Val Glu Arg Pro Leu Ala
490 495 500
gtc acc atg ctc tac ccc ggc att gaa cgc acc cgg gaa acc gcc gag 1651
Val Thr Met Leu Tyr Pro Gly Ile Glu Arg Thr Arg Glu Thr Ala Glu
505 510 515
cgc ctc cgc gat caa ctt cgc gac cgc cta ccc aac tgg atg ctg cca 1699
Arg Leu Arg Asp Gln Leu Arg Asp Arg Leu Pro Asn Trp Met Leu Pro
520 525 530
gaa tat tgg aca ttt gtt gat gag gtg gat aaa acc tcc gtc ggt aaa 1747
Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys Thr Ser Val Gly Lys
535 540 545
tat gac aag aag gac ctc cgc aac cac ctg cgc aac ggc gat ttc gaa 1795
Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg Asn Gly Asp Phe Glu
550 555 560 565
gta att aag ctt aaa ggg cca ggt gaa aaa taacttccct atttattccg 1845
Val Ile Lys Leu Lys Gly Pro Gly Glu Lys
570 575
gct 1848
<210> 64
<211> 575
<212> PRT
<213> Corynebacterium glutamicum
<400> 64
Met Leu Ser Thr Met Gln Asp Val Pro Leu Ser Leu Thr Arg Ile Leu
1 5 10 15
Glu Tyr Gly Ser Thr Val His Gly Asp Thr Leu Ile Thr Thr Trp Gly
20 25 30
Gly Ala Asp Gly Ile Glu Gln Ala Gln Gln Thr Phe Ser Ala Val Gly
35 40 45
Ala Arg Ala Ala Ala Leu Ala His Ala Leu His Asp Ser Leu Gly Ile
50 55 60
Thr Gly Asp Gln Arg Val Ala Ser Met Leu Tyr Asn Cys Ala Glu His
65 70 75 80
Met Glu Thr Met Phe Ala Val Ala Cys Met Gly Ala Val Phe Asn Pro
85 90 95
Leu Asn Lys Gln Leu Met Asn Asp Gln Ile Val Phe Ile Leu Asn His
100 105 110
Ser Glu Ala Glu Val Val Ile Ala Asp Pro Arg Met Ala Glu Gln Leu
115 120 125
Gly Glu Ile Leu Lys Glu Thr Pro Lys Val Arg Ala Val Val Phe Ile
130 135 140
Gly Pro Asn Asp Phe Ser Ser Ala Ala Ala His Met Pro Glu Gly Met
145 150 155 160
Lys Leu Tyr Ser Tyr Glu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr
165 170 175
Asn Trp Pro Glu Gln Asp Glu Arg Thr Ala Ala Ala Ile Cys Tyr Ser
180 185 190
Thr Gly Thr Ser Gly Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser
195 200 205
Leu Tyr Leu Gln Ser Leu Ser Leu Arg Thr Thr Asp Ser Leu Ala Val
210 215 220
Glu His Gly Glu Thr Phe Leu Cys Cys Val Pro Ile Tyr His Val Leu
225 230 235 240
Ser Trp Gly Val Pro Ile Ala Ala Phe Met Ser Gly Thr Pro Leu Val
245 250 255
Leu Pro Gly Pro Asp Leu Ser Ala Pro Thr Leu Ala Lys Ile Ile Ser
260 265 270
Thr Thr Leu Pro Arg Val Ala His Gly Val Pro Thr Leu Trp Ile Gln
275 280 285
Leu Met Val His Tyr Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg
290 295 300
Glu Leu Tyr Val Gly Gly Ser Ala Val Pro Pro Ile Val Ile Thr Met
305 310 315 320
Trp Glu Gln Arg Tyr Gly Val Asp Val Val His Val Trp Gly Met Thr
325 330 335
Glu Thr Ser Thr Val Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser
340 345 350
Gly Glu Ser Arg Trp Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Ala
355 360 365
Ser Leu Gln Tyr Arg Ile Val Asn Asp Gly Gln Val Met Ala Ser Thr
370 375 380
Asp Arg Asn Glu Gly Glu Ile Gln Val Arg Gly Pro Trp Val Thr Ala
385 390 395 400
Ser Tyr Phe His Pro Asp Val Glu Lys Glu Gly Gly Thr Ala Ser Thr
405 410 415
Phe Arg Asp His Asp Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Ala
420 425 430
Asp Gly Trp Leu Arg Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly
435 440 445
Phe Leu Thr Ile Gln Asp Arg Ala Arg Asp Val Ile Arg Ser Gly Gly
450 455 460
Glu Trp Ile Tyr Ser Ala Gln Leu Glu Asn Leu Ile Val Ala Thr Glu
465 470 475 480
Glu Val Val Glu Cys Ala Val Ile Gly Phe Pro Asp Asp Lys Trp Val
485 490 495
Glu Arg Pro Leu Ala Val Thr Met Leu Tyr Pro Gly Ile Glu Arg Thr
500 505 510
Arg Glu Thr Ala Glu Arg Leu Arg Asp Gln Leu Arg Asp Arg Leu Pro
515 520 525
Asn Trp Met Leu Pro Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys
530 535 540
Thr Ser Val Gly Lys Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg
545 550 555 560
Asn Gly Asp Phe Glu Val Ile Lys Leu Lys Gly Pro Gly Glu Lys
565 570 575
<210> 65
<211> 1848
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1825)
<223> FRXA01722
<220>
<221> VARIANT
<222> 479
<223> Xaa = Thr
<220>
<221> VARIANT
<222> 574
<223> Xaa = Glu
<400> 65
ctcattcccc tcgctaaaag ctgcataaag tttcgacgtt ttcaaagttg attgcttgca 60
ctgtcgttgc gtgtcgcatg ccccggctat tgttgattgc atg ctc agc acg atg 115
Met Leu Ser Thr Met
1 5
cag gac gtc cca ctg tca tta acc aga atc ctc gag tac ggg tcc act 163
Gln Asp Val Pro Leu Ser Leu Thr Arg Ile Leu Glu Tyr Gly Ser Thr
10 15 20
gtt cac ggt gat act ttg atc acc acg tgg ggc ggt gcc gat ggc att 211
Val His Gly Asp Thr Leu Ile Thr Thr Trp Gly Gly Ala Asp Gly Ile
25 30 35
gaa caa gca cag caa act ttt agt gct gtg ggg gct aga gct gcg gct 259
Glu Gln Ala Gln Gln Thr Phe Ser Ala Val Gly Ala Arg Ala Ala Ala
40 45 50
ttg gct cat gcg ctg cat gat tct tta ggt att act ggg gat cag cga 307
Leu Ala His Ala Leu His Asp Ser Leu Gly Ile Thr Gly Asp Gln Arg
55 60 65
gtg gcg tcg atg ctc tat aac tgc gcg gaa cac atg gaa act atg ttt 355
Val Ala Ser Met Leu Tyr Asn Cys Ala Glu His Met Glu Thr Met Phe
70 75 80 85
gca gtc gca tgc atg ggt gcc gtg ttt aat ccg ctg aac aag cag ttg 403
Ala Val Ala Cys Met Gly Ala Val Phe Asn Pro Leu Asn Lys Gln Leu
90 95 100
atg aat gat cag att gtg ttc att ctc aat cac tct gaa gct gaa gtg 451
Met Asn Asp Gln Ile Val Phe Ile Leu Asn His Ser Glu Ala Glu Val
105 110 115
gtt atc gct gat ccg cgc atg gct gaa caa ttg ggt gag atc tta aaa 499
Val Ile Ala Asp Pro Arg Met Ala Glu Gln Leu Gly Glu Ile Leu Lys
120 125 130
gaa aca cca aaa gtt cgt gcc gtg gtg ttt att gga ccg aat gat ttc 547
Glu Thr Pro Lys Val Arg Ala Val Val Phe Ile Gly Pro Asn Asp Phe
135 140 145
tct agc gcg gcg gcc cac atg ccg gag gga atg aag ctg tat tcc tat 595
Ser Ser Ala Ala Ala His Met Pro Glu Gly Met Lys Leu Tyr Ser Tyr
150 155 160 165
gaa gcg ctc ctt gac ggc cgt tcc act gtt tac aac tgg ccc gag cag 643
Glu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr Asn Trp Pro Glu Gln
170 175 180
gat gaa cgc act gct gct gca att tgc tat tcc acc ggt aca tcg gga 691
Asp Glu Arg Thr Ala Ala Ala Ile Cys Tyr Ser Thr Gly Thr Ser Gly
185 190 195
ccg ccg aag ggt gtg gtg tat tcc cac cgc tcg ctt tat tta cag tcg 739
Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser Leu Tyr Leu Gln Ser
200 205 210
ttg agc ttg cgc acc acg gat tcc ctc gca gtg gaa cac ggc gaa acg 787
Leu Ser Leu Arg Thr Thr Asp Ser Leu Ala Val Glu His Gly Glu Thr
215 220 225
ttc ctg tgc tgt gtg ccg att tac cac gtc ctc agc tgg ggc gtg ccg 835
Phe Leu Cys Cys Val Pro Ile Tyr His Val Leu Ser Trp Gly Val Pro
230 235 240 245
atc gca gcg ttt atg tcc ggc act ccc ctg gtg ctt cct gga ccg gat 883
Ile Ala Ala Phe Met Ser Gly Thr Pro Leu Val Leu Pro Gly Pro Asp
250 255 260
ctt tct gcg ccg aca ttg gca aag atc att tcc acc acg ctg cct cgc 931
Leu Ser Ala Pro Thr Leu Ala Lys Ile Ile Ser Thr Thr Leu Pro Arg
265 270 275
gtg gcg cat ggc gtg cct act ctc tgg att cag ctg atg gtt cac tac 979
Val Ala His Gly Val Pro Thr Leu Trp Ile Gln Leu Met Val His Tyr
280 285 290
ctg aaa aat ccc cca gag cgt atg tct ctg cgt gag cta tac gtg ggc 1027
Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg Glu Leu Tyr Val Gly
295 300 305
ggt tct gcg gtg cct cca atc gtg atc acc atg tgg gag cag cgc tat 1075
Gly Ser Ala Val Pro Pro Ile Val Ile Thr Met Trp Glu Gln Arg Tyr
310 315 320 325
ggc gtg gat gtt gtc cac gtg tgg ggt atg acg gaa acc tcc acc gtg 1123
Gly Val Asp Val Val His Val Trp Gly Met Thr Glu Thr Ser Thr Val
330 335 340
ggt act gtg tct cgc cca cca tca ggt gtt tct ggt gaa agc cgg tgg 1171
Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser Gly Glu Ser Arg Trp
345 350 355
aat tat cga gtc tcc cag ggc cga ttc ccc gcc tcc ctg cag tac cgc 1219
Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Ala Ser Leu Gln Tyr Arg
360 365 370
att gtc aac gac ggc cag gtc atg gcg tcc acc gac cgc aac gag ggc 1267
Ile Val Asn Asp Gly Gln Val Met Ala Ser Thr Asp Arg Asn Glu Gly
375 380 385
gag att cag gtc cgc ggt ccg tgg gtg act gca agt tac ttc cac ccc 1315
Glu Ile Gln Val Arg Gly Pro Trp Val Thr Ala Ser Tyr Phe His Pro
390 395 400 405
gat gtg gaa aaa gaa ggt ggc acc gcc tca aca ttc cgc gac cat gac 1363
Asp Val Glu Lys Glu Gly Gly Thr Ala Ser Thr Phe Arg Asp His Asp
410 415 420
gtt gaa gag gaa aac gat gag ctc ttc acc gcc gac ggc tgg ctg cgc 1411
Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Ala Asp Gly Trp Leu Arg
425 430 435
acc ggg gac gtt gga tct gtc acc agc gat gga ttc ctc acc atc caa 1459
Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly Phe Leu Thr Ile Gln
440 445 450
gac cgc gcc cgc gat gtc atc cgt tct ggc ggc gag tgg att tac tcc 1507
Asp Arg Ala Arg Asp Val Ile Arg Ser Gly Gly Glu Trp Ile Tyr Ser
455 460 465
gct cag ctg gaa aac ctc atc gtg gct acs gaa gag gtt gtc gaa tgc 1555
Ala Gln Leu Glu Asn Leu Ile Val Ala Xaa Glu Glu Val Val Glu Cys
470 475 480 485
gcc gtc att ggc ttc ccc gat gac aag tgg gtg gaa cgt ccc ctc gca 1603
Ala Val Ile Gly Phe Pro Asp Asp Lys Trp Val Glu Arg Pro Leu Ala
490 495 500
gtc acc atg ctc tac ccc ggc att gaa cgc acc cgg gaa acc gcc gag 1651
Val Thr Met Leu Tyr Pro Gly Ile Glu Arg Thr Arg Glu Thr Ala Glu
505 510 515
cgc ctc cgc gat caa ctt cgc gac cgc cta ccc aac tgg atg ctg cca 1699
Arg Leu Arg Asp Gln Leu Arg Asp Arg Leu Pro Asn Trp Met Leu Pro
520 525 530
gaa tat tgg aca ttt gtt gat gag gtg gat aaa acc tcc gtc ggt aaa 1747
Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys Thr Ser Val Gly Lys
535 540 545
tat gac aag aag gac ctc cgc aac cac ctg cgc aac ggc gat ttc gaa 1795
Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg Asn Gly Asp Phe Glu
550 555 560 565
gta att aag ctt aaa ggg cca ggt gar aaa taacttccct atttattccg 1845
Val Ile Lys Leu Lys Gly Pro Gly Xaa Lys
570 575
gct 1848
<210> 66
<211> 575
<212> PRT
<213> Corynebacterium glutamicum
<220>
<221> VARIANT
<222> 479
<223> Xaa = Thr
<220>
<221> VARIANT
<222> 574
<223> Xaa = Glu
<400> 66
Met Leu Ser Thr Met Gln Asp Val Pro Leu Ser Leu Thr Arg Ile Leu
1 5 10 15
Glu Tyr Gly Ser Thr Val His Gly Asp Thr Leu Ile Thr Thr Trp Gly
20 25 30
Gly Ala Asp Gly Ile Glu Gln Ala Gln Gln Thr Phe Ser Ala Val Gly
35 40 45
Ala Arg Ala Ala Ala Leu Ala His Ala Leu His Asp Ser Leu Gly Ile
50 55 60
Thr Gly Asp Gln Arg Val Ala Ser Met Leu Tyr Asn Cys Ala Glu His
65 70 75 80
Met Glu Thr Met Phe Ala Val Ala Cys Met Gly Ala Val Phe Asn Pro
85 90 95
Leu Asn Lys Gln Leu Met Asn Asp Gln Ile Val Phe Ile Leu Asn His
100 105 110
Ser Glu Ala Glu Val Val Ile Ala Asp Pro Arg Met Ala Glu Gln Leu
115 120 125
Gly Glu Ile Leu Lys Glu Thr Pro Lys Val Arg Ala Val Val Phe Ile
130 135 140
Gly Pro Asn Asp Phe Ser Ser Ala Ala Ala His Met Pro Glu Gly Met
145 150 155 160
Lys Leu Tyr Ser Tyr Glu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr
165 170 175
Asn Trp Pro Glu Gln Asp Glu Arg Thr Ala Ala Ala Ile Cys Tyr Ser
180 185 190
Thr Gly Thr Ser Gly Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser
195 200 205
Leu Tyr Leu Gln Ser Leu Ser Leu Arg Thr Thr Asp Ser Leu Ala Val
210 215 220
Glu His Gly Glu Thr Phe Leu Cys Cys Val Pro Ile Tyr His Val Leu
225 230 235 240
Ser Trp Gly Val Pro Ile Ala Ala Phe Met Ser Gly Thr Pro Leu Val
245 250 255
Leu Pro Gly Pro Asp Leu Ser Ala Pro Thr Leu Ala Lys Ile Ile Ser
260 265 270
Thr Thr Leu Pro Arg Val Ala His Gly Val Pro Thr Leu Trp Ile Gln
275 280 285
Leu Met Val His Tyr Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg
290 295 300
Glu Leu Tyr Val Gly Gly Ser Ala Val Pro Pro Ile Val Ile Thr Met
305 310 315 320
Trp Glu Gln Arg Tyr Gly Val Asp Val Val His Val Trp Gly Met Thr
325 330 335
Glu Thr Ser Thr Val Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser
340 345 350
Gly Glu Ser Arg Trp Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Ala
355 360 365
Ser Leu Gln Tyr Arg Ile Val Asn Asp Gly Gln Val Met Ala Ser Thr
370 375 380
Asp Arg Asn Glu Gly Glu Ile Gln Val Arg Gly Pro Trp Val Thr Ala
385 390 395 400
Ser Tyr Phe His Pro Asp Val Glu Lys Glu Gly Gly Thr Ala Ser Thr
405 410 415
Phe Arg Asp His Asp Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Ala
420 425 430
Asp Gly Trp Leu Arg Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly
435 440 445
Phe Leu Thr Ile Gln Asp Arg Ala Arg Asp Val Ile Arg Ser Gly Gly
450 455 460
Glu Trp Ile Tyr Ser Ala Gln Leu Glu Asn Leu Ile Val Ala Xaa Glu
465 470 475 480
Glu Val Val Glu Cys Ala Val Ile Gly Phe Pro Asp Asp Lys Trp Val
485 490 495
Glu Arg Pro Leu Ala Val Thr Met Leu Tyr Pro Gly Ile Glu Arg Thr
500 505 510
Arg Glu Thr Ala Glu Arg Leu Arg Asp Gln Leu Arg Asp Arg Leu Pro
515 520 525
Asn Trp Met Leu Pro Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys
530 535 540
Thr Ser Val Gly Lys Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg
545 550 555 560
Asn Gly Asp Phe Glu Val Ile Lys Leu Lys Gly Pro Gly Xaa Lys
565 570 575
<210> 67
<211> 1401
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1378)
<223> RXA01644
<400> 67
gtaggtagag gcttgtggtc actacttgtg gccacatttt aaaaaaatgc acaagaagag 60
aaagcaaagc attatgagta acgccgtagc gcaggacctc atg acc atc gcc gac 115
Met Thr Ile Ala Asp
1 5
atc gtc gag gcc acg acc act gca ccc atc cca ttc cac atc act gcc 163
Ile Val Glu Ala Thr Thr Thr Ala Pro Ile Pro Phe His Ile Thr Ala
10 15 20
ttc gat gga agc ttc act ggc cct gaa gat gct ccc tac cag ctg ttt 211
Phe Asp Gly Ser Phe Thr Gly Pro Glu Asp Ala Pro Tyr Gln Leu Phe
25 30 35
gtt gcc aac acg gat gca gta tcc tac atc gca aca gcg cca gga gat 259
Val Ala Asn Thr Asp Ala Val Ser Tyr Ile Ala Thr Ala Pro Gly Asp
40 45 50
ttg ggt ttg gca cgt gcc tac ctc atg gga gac ctc atc gtg gaa ggt 307
Leu Gly Leu Ala Arg Ala Tyr Leu Met Gly Asp Leu Ile Val Glu Gly
55 60 65
gag cat ccc ggc cat cct tat ggg atc ttt gat gcg ttg aag gag ttc 355
Glu His Pro Gly His Pro Tyr Gly Ile Phe Asp Ala Leu Lys Glu Phe
70 75 80 85
tac cgc tgc ttc aaa cgc cca gat gca tcc acc acc ttg cag atc atg 403
Tyr Arg Cys Phe Lys Arg Pro Asp Ala Ser Thr Thr Leu Gln Ile Met
90 95 100
tgg act ctg cgg aaa atg aat gcc tta aaa ttc cag gaa att cca cca 451
Trp Thr Leu Arg Lys Met Asn Ala Leu Lys Phe Gln Glu Ile Pro Pro
105 110 115
atg gaa caa gcc cct gca tgg cgt aaa gca ctg atc aac ggg cta gca 499
Met Glu Gln Ala Pro Ala Trp Arg Lys Ala Leu Ile Asn Gly Leu Ala
120 125 130
tcc agg cac tcg aaa tcc cgc gac aag aaa gcc att agc tac cac tac 547
Ser Arg His Ser Lys Ser Arg Asp Lys Lys Ala Ile Ser Tyr His Tyr
135 140 145
gac gtg ggc aat gag ttc tac tcc ctg ttt tta gat gat tcc atg acc 595
Asp Val Gly Asn Glu Phe Tyr Ser Leu Phe Leu Asp Asp Ser Met Thr
150 155 160 165
tat acc tgc gcg tat tat cca acg cca gaa tca agt ttg gaa gaa gcc 643
Tyr Thr Cys Ala Tyr Tyr Pro Thr Pro Glu Ser Ser Leu Glu Glu Ala
170 175 180
caa gaa aac aaa tac cgc ctc atc ttt gaa aaa ctg cgt ctg aaa gaa 691
Gln Glu Asn Lys Tyr Arg Leu Ile Phe Glu Lys Leu Arg Leu Lys Glu
185 190 195
ggc gat cgc ctc cta gac gtg gga tgc ggt tgg gga ggc atg gtc cgc 739
Gly Asp Arg Leu Leu Asp Val Gly Cys Gly Trp Gly Gly Met Val Arg
200 205 210
tac gcc gcc aaa cac ggt gtg aaa gcc atc gga gtt acg ctg tct gaa 787
Tyr Ala Ala Lys His Gly Val Lys Ala Ile Gly Val Thr Leu Ser Glu
215 220 225
cag caa tat gag tgg ggt caa gca gag atc aaa cgc caa ggt ttg gaa 835
Gln Gln Tyr Glu Trp Gly Gln Ala Glu Ile Lys Arg Gln Gly Leu Glu
230 235 240 245
gac ctc gcg gaa att cgc ttc atg gat tac cgc gat gtt cca gaa act 883
Asp Leu Ala Glu Ile Arg Phe Met Asp Tyr Arg Asp Val Pro Glu Thr
250 255 260
gga ttc gat gcg atc tca gca atc ggc atc att gaa cac atc ggt gtg 931
Gly Phe Asp Ala Ile Ser Ala Ile Gly Ile Ile Glu His Ile Gly Val
265 270 275
aac aac tat ccc gac tac ttt gaa ttg ctc agc agc aaa ctc aaa aca 979
Asn Asn Tyr Pro Asp Tyr Phe Glu Leu Leu Ser Ser Lys Leu Lys Thr
280 285 290
ggc gga ctg atg ctc aac cac agc atc acc tac cca gac aac cgc ccc 1027
Gly Gly Leu Met Leu Asn His Ser Ile Thr Tyr Pro Asp Asn Arg Pro
295 300 305
cgc cac gca ggt gca ttt att gat cgc tac att ttc ccc gac ggt gaa 1075
Arg His Ala Gly Ala Phe Ile Asp Arg Tyr Ile Phe Pro Asp Gly Glu
310 315 320 325
ctc act ggc tct ggc acc ctg atc aag cac atg cag gac aac ggt ttc 1123
Leu Thr Gly Ser Gly Thr Leu Ile Lys His Met Gln Asp Asn Gly Phe
330 335 340
gaa gtg ctg cac gaa gaa aac ctc cgc ttt gat tac caa cgc acc ctg 1171
Glu Val Leu His Glu Glu Asn Leu Arg Phe Asp Tyr Gln Arg Thr Leu
345 350 355
cac gcg tgg tgc gaa aac ctc aaa gaa aat tgg gag gaa gca gtt gaa 1219
His Ala Trp Cys Glu Asn Leu Lys Glu Asn Trp Glu Glu Ala Val Glu
360 365 370
ctc gcc ggt gaa ccc act gca cga ctc ttt ggc ctg tac atg gca ggt 1267
Leu Ala Gly Glu Pro Thr Ala Arg Leu Phe Gly Leu Tyr Met Ala Gly
375 380 385
tcg gaa tgg gga ttt gcc cac aac atc gtc cag ctg cac caa gta ctg 1315
Ser Glu Trp Gly Phe Ala His Asn Ile Val Gln Leu His Gln Val Leu
390 395 400 405
ggt gtg aaa ctc gat gag cag gga agt cgc gga gaa gtt cct gaa aga 1363
Gly Val Lys Leu Asp Glu Gln Gly Ser Arg Gly Glu Val Pro Glu Arg
410 415 420
atg tgg tgg act atc taaagaaaca atgtttcttt tta 1401
Met Trp Trp Thr Ile
425
<210> 68
<211> 426
<212> PRT
<213> Corynebacterium glutamicum
<400> 68
Met Thr Ile Ala Asp Ile Val Glu Ala Thr Thr Thr Ala Pro Ile Pro
1 5 10 15
Phe His Ile Thr Ala Phe Asp Gly Ser Phe Thr Gly Pro Glu Asp Ala
20 25 30
Pro Tyr Gln Leu Phe Val Ala Asn Thr Asp Ala Val Ser Tyr Ile Ala
35 40 45
Thr Ala Pro Gly Asp Leu Gly Leu Ala Arg Ala Tyr Leu Met Gly Asp
50 55 60
Leu Ile Val Glu Gly Glu His Pro Gly His Pro Tyr Gly Ile Phe Asp
65 70 75 80
Ala Leu Lys Glu Phe Tyr Arg Cys Phe Lys Arg Pro Asp Ala Ser Thr
85 90 95
Thr Leu Gln Ile Met Trp Thr Leu Arg Lys Met Asn Ala Leu Lys Phe
100 105 110
Gln Glu Ile Pro Pro Met Glu Gln Ala Pro Ala Trp Arg Lys Ala Leu
115 120 125
Ile Asn Gly Leu Ala Ser Arg His Ser Lys Ser Arg Asp Lys Lys Ala
130 135 140
Ile Ser Tyr His Tyr Asp Val Gly Asn Glu Phe Tyr Ser Leu Phe Leu
145 150 155 160
Asp Asp Ser Met Thr Tyr Thr Cys Ala Tyr Tyr Pro Thr Pro Glu Ser
165 170 175
Ser Leu Glu Glu Ala Gln Glu Asn Lys Tyr Arg Leu Ile Phe Glu Lys
180 185 190
Leu Arg Leu Lys Glu Gly Asp Arg Leu Leu Asp Val Gly Cys Gly Trp
195 200 205
Gly Gly Met Val Arg Tyr Ala Ala Lys His Gly Val Lys Ala Ile Gly
210 215 220
Val Thr Leu Ser Glu Gln Gln Tyr Glu Trp Gly Gln Ala Glu Ile Lys
225 230 235 240
Arg Gln Gly Leu Glu Asp Leu Ala Glu Ile Arg Phe Met Asp Tyr Arg
245 250 255
Asp Val Pro Glu Thr Gly Phe Asp Ala Ile Ser Ala Ile Gly Ile Ile
260 265 270
Glu His Ile Gly Val Asn Asn Tyr Pro Asp Tyr Phe Glu Leu Leu Ser
275 280 285
Ser Lys Leu Lys Thr Gly Gly Leu Met Leu Asn His Ser Ile Thr Tyr
290 295 300
Pro Asp Asn Arg Pro Arg His Ala Gly Ala Phe Ile Asp Arg Tyr Ile
305 310 315 320
Phe Pro Asp Gly Glu Leu Thr Gly Ser Gly Thr Leu Ile Lys His Met
325 330 335
Gln Asp Asn Gly Phe Glu Val Leu His Glu Glu Asn Leu Arg Phe Asp
340 345 350
Tyr Gln Arg Thr Leu His Ala Trp Cys Glu Asn Leu Lys Glu Asn Trp
355 360 365
Glu Glu Ala Val Glu Leu Ala Gly Glu Pro Thr Ala Arg Leu Phe Gly
370 375 380
Leu Tyr Met Ala Gly Ser Glu Trp Gly Phe Ala His Asn Ile Val Gln
385 390 395 400
Leu His Gln Val Leu Gly Val Lys Leu Asp Glu Gln Gly Ser Arg Gly
405 410 415
Glu Val Pro Glu Arg Met Trp Trp Thr Ile
420 425
<210> 69
<211> 1437
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1414)
<223> RXA02029
<400> 69
cgcacgtaca ctacttttag cagttaaccc gccgaacttt cttgattaag tattcattga 60
gcgttcttgg cataaatccc actggaggtg catcaaacgt atg gca gag gca cgt 115
Met Ala Glu Ala Arg
1 5
ttg cgc cat ctt gaa ccc att gat gtg gaa gag tgg cct ggg gtg gcg 163
Leu Arg His Leu Glu Pro Ile Asp Val Glu Glu Trp Pro Gly Val Ala
10 15 20
tca gtg ccc aac cta gcg ttt gct ggt gca cgc gca cgg caa gca gaa 211
Ser Val Pro Asn Leu Ala Phe Ala Gly Ala Arg Ala Arg Gln Ala Glu
25 30 35
tat cga ttt gcc aag gcc tgc agc aac gca ggt tta gtt ctg cta gga 259
Tyr Arg Phe Ala Lys Ala Cys Ser Asn Ala Gly Leu Val Leu Leu Gly
40 45 50
aat gac ccg gat ctc att att gat cat gag gaa tta ttc tca cgt ttg 307
Asn Asp Pro Asp Leu Ile Ile Asp His Glu Glu Leu Phe Ser Arg Leu
55 60 65
gcc gca tcg ggc tgg ctg ggg ctc gct gag agc tac atg gca ggc gag 355
Ala Ala Ser Gly Trp Leu Gly Leu Ala Glu Ser Tyr Met Ala Gly Glu
70 75 80 85
tgg cgc agc gag agg ctt gcc gac gtc ttg acc gct ttg ttg gga act 403
Trp Arg Ser Glu Arg Leu Ala Asp Val Leu Thr Ala Leu Leu Gly Thr
90 95 100
ggg ttt aaa ccc cgc ggc aaa cta tct gga tcg ttc acc ctg cca ggg 451
Gly Phe Lys Pro Arg Gly Lys Leu Ser Gly Ser Phe Thr Leu Pro Gly
105 110 115
caa gct gtg gat gcc gga ggc gca cta ccc aat gaa ctc att cgt tta 499
Gln Ala Val Asp Ala Gly Gly Ala Leu Pro Asn Glu Leu Ile Arg Leu
120 125 130
agt tca ggt gat ggc atg agc gca ttt ggt gga gtt ttt gcc tcc ggt 547
Ser Ser Gly Asp Gly Met Ser Ala Phe Gly Gly Val Phe Ala Ser Gly
135 140 145
gtt cca acc act tta cgt acc gca gtg aaa agc cat gtg ccg gga gct 595
Val Pro Thr Thr Leu Arg Thr Ala Val Lys Ser His Val Pro Gly Ala
150 155 160 165
ggt cgc aat agg gag ccc gca tct cac ttt gtg gat atc acc aag atc 643
Gly Arg Asn Arg Glu Pro Ala Ser His Phe Val Asp Ile Thr Lys Ile
170 175 180
tcg gag cct gtg gcc gtg gag cgt gaa gac ctc ggc gag gct cag cgc 691
Ser Glu Pro Val Ala Val Glu Arg Glu Asp Leu Gly Glu Ala Gln Arg
185 190 195
cga gca gcg tcc ttt ttg ctt gac ggc gcc aaa gtt aaa gcc gga agc 739
Arg Ala Ala Ser Phe Leu Leu Asp Gly Ala Lys Val Lys Ala Gly Ser
200 205 210
cat gtg ttg gag ttt ccc agc agt ggt gga gct tta gct att ttg gct 787
His Val Leu Glu Phe Pro Ser Ser Gly Gly Ala Leu Ala Ile Leu Ala
215 220 225
gct cga cgc cag gga act gtt gac gct tta acg gct gat ccc gcg caa 835
Ala Arg Arg Gln Gly Thr Val Asp Ala Leu Thr Ala Asp Pro Ala Gln
230 235 240 245
gtt tca agc ctg gag gag acg ttt gtg ctc gcc ggt gtg gag gag gat 883
Val Ser Ser Leu Glu Glu Thr Phe Val Leu Ala Gly Val Glu Glu Asp
250 255 260
att cac atc gag gtc att ccc cag gcg att ccc tcg cca cgc gaa tgg 931
Ile His Ile Glu Val Ile Pro Gln Ala Ile Pro Ser Pro Arg Glu Trp
265 270 275
ggt ggc gcc tac gat tcg ata gtc gcc atg gag aag cta gaa gtg gtg 979
Gly Gly Ala Tyr Asp Ser Ile Val Ala Met Glu Lys Leu Glu Val Val
280 285 290
ggc aag cac ggt tcc aag cgg ttt att aaa gct atc gac aga atg ctc 1027
Gly Lys His Gly Ser Lys Arg Phe Ile Lys Ala Ile Asp Arg Met Leu
295 300 305
acc acc ggc ggc aac gta gcc atg caa tcc ttg gta gct act gac caa 1075
Thr Thr Gly Gly Asn Val Ala Met Gln Ser Leu Val Ala Thr Asp Gln
310 315 320 325
tgg agt cct gtg tgt tct gaa gcg att tct ttg ctc aag gcc tat att 1123
Trp Ser Pro Val Cys Ser Glu Ala Ile Ser Leu Leu Lys Ala Tyr Ile
330 335 340
tgg cct gcg ctg cat tac cca act gtt gat gaa gtt cat cag ctt gtt 1171
Trp Pro Ala Leu His Tyr Pro Thr Val Asp Glu Val His Gln Leu Val
345 350 355
gat agg gat tct tct ctg cgc gtg gtg aag gaa aca cac ttt gcg ggc 1219
Asp Arg Asp Ser Ser Leu Arg Val Val Lys Glu Thr His Phe Ala Gly
360 365 370
cat tac cta aaa agc gtg cag ttg caa cgt gaa gtg ttt gaa ggc cag 1267
His Tyr Leu Lys Ser Val Gln Leu Gln Arg Glu Val Phe Glu Gly Gln
375 380 385
ata cgc gaa gcg gcg gca gat ggc ttt gat gcc gtc tac cgc cgc atg 1315
Ile Arg Glu Ala Ala Ala Asp Gly Phe Asp Ala Val Tyr Arg Arg Met
390 395 400 405
tgg gtg tat cac tac gcg ctt att gaa gcc ctg tta cgc ctg gga tgt 1363
Trp Val Tyr His Tyr Ala Leu Ile Glu Ala Leu Leu Arg Leu Gly Cys
410 415 420
ctc aat gca gtg caa ttt gcg ttg acg aca aga aac aga agg ggg cgt 1411
Leu Asn Ala Val Gln Phe Ala Leu Thr Thr Arg Asn Arg Arg Gly Arg
425 430 435
cga taagcaaaaa tcttttagac ctc 1437
Arg
<210> 70
<211> 438
<212> PRT
<213> Corynebacterium glutamicum
<400> 70
Met Ala Glu Ala Arg Leu Arg His Leu Glu Pro Ile Asp Val Glu Glu
1 5 10 15
Trp Pro Gly Val Ala Ser Val Pro Asn Leu Ala Phe Ala Gly Ala Arg
20 25 30
Ala Arg Gln Ala Glu Tyr Arg Phe Ala Lys Ala Cys Ser Asn Ala Gly
35 40 45
Leu Val Leu Leu Gly Asn Asp Pro Asp Leu Ile Ile Asp His Glu Glu
50 55 60
Leu Phe Ser Arg Leu Ala Ala Ser Gly Trp Leu Gly Leu Ala Glu Ser
65 70 75 80
Tyr Met Ala Gly Glu Trp Arg Ser Glu Arg Leu Ala Asp Val Leu Thr
85 90 95
Ala Leu Leu Gly Thr Gly Phe Lys Pro Arg Gly Lys Leu Ser Gly Ser
100 105 110
Phe Thr Leu Pro Gly Gln Ala Val Asp Ala Gly Gly Ala Leu Pro Asn
115 120 125
Glu Leu Ile Arg Leu Ser Ser Gly Asp Gly Met Ser Ala Phe Gly Gly
130 135 140
Val Phe Ala Ser Gly Val Pro Thr Thr Leu Arg Thr Ala Val Lys Ser
145 150 155 160
His Val Pro Gly Ala Gly Arg Asn Arg Glu Pro Ala Ser His Phe Val
165 170 175
Asp Ile Thr Lys Ile Ser Glu Pro Val Ala Val Glu Arg Glu Asp Leu
180 185 190
Gly Glu Ala Gln Arg Arg Ala Ala Ser Phe Leu Leu Asp Gly Ala Lys
195 200 205
Val Lys Ala Gly Ser His Val Leu Glu Phe Pro Ser Ser Gly Gly Ala
210 215 220
Leu Ala Ile Leu Ala Ala Arg Arg Gln Gly Thr Val Asp Ala Leu Thr
225 230 235 240
Ala Asp Pro Ala Gln Val Ser Ser Leu Glu Glu Thr Phe Val Leu Ala
245 250 255
Gly Val Glu Glu Asp Ile His Ile Glu Val Ile Pro Gln Ala Ile Pro
260 265 270
Ser Pro Arg Glu Trp Gly Gly Ala Tyr Asp Ser Ile Val Ala Met Glu
275 280 285
Lys Leu Glu Val Val Gly Lys His Gly Ser Lys Arg Phe Ile Lys Ala
290 295 300
Ile Asp Arg Met Leu Thr Thr Gly Gly Asn Val Ala Met Gln Ser Leu
305 310 315 320
Val Ala Thr Asp Gln Trp Ser Pro Val Cys Ser Glu Ala Ile Ser Leu
325 330 335
Leu Lys Ala Tyr Ile Trp Pro Ala Leu His Tyr Pro Thr Val Asp Glu
340 345 350
Val His Gln Leu Val Asp Arg Asp Ser Ser Leu Arg Val Val Lys Glu
355 360 365
Thr His Phe Ala Gly His Tyr Leu Lys Ser Val Gln Leu Gln Arg Glu
370 375 380
Val Phe Glu Gly Gln Ile Arg Glu Ala Ala Ala Asp Gly Phe Asp Ala
385 390 395 400
Val Tyr Arg Arg Met Trp Val Tyr His Tyr Ala Leu Ile Glu Ala Leu
405 410 415
Leu Arg Leu Gly Cys Leu Asn Ala Val Gln Phe Ala Leu Thr Thr Arg
420 425 430
Asn Arg Arg Gly Arg Arg
435
<210> 71
<211> 1140
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1117)
<223> RXA01801
<400> 71
tttggattcc tttccgatta tgtcttgatc gcccattctg tcacatccgg gttgtctaaa 60
cacccgcgaa gatttcctgt gatgtgccac actggttctc atg tct aac gta gtg 115
Met Ser Asn Val Val
1 5
aac act ttt gtc cag aat tcc acc ggt atg gtg gag ctt aat cgt ccc 163
Asn Thr Phe Val Gln Asn Ser Thr Gly Met Val Glu Leu Asn Arg Pro
10 15 20
aaa gcg ctc aat tct ctt aat cag gaa atg atc gat ctc gtt cag gaa 211
Lys Ala Leu Asn Ser Leu Asn Gln Glu Met Ile Asp Leu Val Gln Glu
25 30 35
gct cta acc act tgg gct gat gat gat cag gtg cag cag gtt ctc att 259
Ala Leu Thr Thr Trp Ala Asp Asp Asp Gln Val Gln Gln Val Leu Ile
40 45 50
tac tca tcc tcg gag cgt gca ttt tgt gcc ggc ggt gat gtg cgc gcg 307
Tyr Ser Ser Ser Glu Arg Ala Phe Cys Ala Gly Gly Asp Val Arg Ala
55 60 65
gtc cgt gag agc gtg ttg gag ggc gat gtt gcg gcc ggc gat aag tat 355
Val Arg Glu Ser Val Leu Glu Gly Asp Val Ala Ala Gly Asp Lys Tyr
70 75 80 85
ttc atc gat gag ttc gcg atg aac aac acg ttg gga acc tat ccg aag 403
Phe Ile Asp Glu Phe Ala Met Asn Asn Thr Leu Gly Thr Tyr Pro Lys
90 95 100
ccg gtc att tct gtg atc aac ggc gtc gcg atg ggt ggc gga atg gga 451
Pro Val Ile Ser Val Ile Asn Gly Val Ala Met Gly Gly Gly Met Gly
105 110 115
att tcc atg cat gga tcg cac cgg atc gtc acg gaa aaa gcg ttc gcg 499
Ile Ser Met His Gly Ser His Arg Ile Val Thr Glu Lys Ala Phe Ala
120 125 130
tcg atg cct gag atg gcg atc ggc tat gtt ccc gat gtg ggc ttt act 547
Ser Met Pro Glu Met Ala Ile Gly Tyr Val Pro Asp Val Gly Phe Thr
135 140 145
tat ttc ggt cag cgt gca tcg tcg ctg gcc atc gcc aca ttt ttg gcg 595
Tyr Phe Gly Gln Arg Ala Ser Ser Leu Ala Ile Ala Thr Phe Leu Ala
150 155 160 165
gtg acc ggg tgg cgc atg agc cct gcc gat atg ctg tgg gct ggc gtc 643
Val Thr Gly Trp Arg Met Ser Pro Ala Asp Met Leu Trp Ala Gly Val
170 175 180
gca acg cat ttt gtt gag gat gcg cag ggg ttc att gat gcg gtc ttg 691
Ala Thr His Phe Val Glu Asp Ala Gln Gly Phe Ile Asp Ala Val Leu
185 190 195
aac gag tcg ctt gat ggc gcg ctg gag aaa ttc tcc acg caa cct acg 739
Asn Glu Ser Leu Asp Gly Ala Leu Glu Lys Phe Ser Thr Gln Pro Thr
200 205 210
ggc agc agc gag ctg gcc ggc gtc gcc agc cag att gag gag acc ttt 787
Gly Ser Ser Glu Leu Ala Gly Val Ala Ser Gln Ile Glu Glu Thr Phe
215 220 225
ggg cac agc tct tgg gcg ctt atc gac gcc tcc ctc cgg tct cac ccc 835
Gly His Ser Ser Trp Ala Leu Ile Asp Ala Ser Leu Arg Ser His Pro
230 235 240 245
gat gct gaa ttt gtt gcc aag gtg gat ggg ctg atg gcg tcg gca gca 883
Asp Ala Glu Phe Val Ala Lys Val Asp Gly Leu Met Ala Ser Ala Ala
250 255 260
ccg gca tcg gtg gtg gct acc gtg aag ctg atg cat caa aac agt gag 931
Pro Ala Ser Val Val Ala Thr Val Lys Leu Met His Gln Asn Ser Glu
265 270 275
gcg acc act ctg cgt gaa ggc ttg gac aat gaa ttg gcg atg tct ctt 979
Ala Thr Thr Leu Arg Glu Gly Leu Asp Asn Glu Leu Ala Met Ser Leu
280 285 290
tat atg atc cgc cag cct gat ttt gct gaa ggt gtg cgt gca gtg ttg 1027
Tyr Met Ile Arg Gln Pro Asp Phe Ala Glu Gly Val Arg Ala Val Leu
295 300 305
gtt gat aaa gac cgc aat gca gcc ttc tcc cca gcc aac tac gaa gat 1075
Val Asp Lys Asp Arg Asn Ala Ala Phe Ser Pro Ala Asn Tyr Glu Asp
310 315 320 325
gtt gat gag tca cat ttt gtg acc ttg ttc cag cgc agt tca 1117
Val Asp Glu Ser His Phe Val Thr Leu Phe Gln Arg Ser Ser
330 335
taaaaccgcc aaacttttga tag 1140
<210> 72
<211> 339
<212> PRT
<213> Corynebacterium glutamicum
<400> 72
Met Ser Asn Val Val Asn Thr Phe Val Gln Asn Ser Thr Gly Met Val
1 5 10 15
Glu Leu Asn Arg Pro Lys Ala Leu Asn Ser Leu Asn Gln Glu Met Ile
20 25 30
Asp Leu Val Gln Glu Ala Leu Thr Thr Trp Ala Asp Asp Asp Gln Val
35 40 45
Gln Gln Val Leu Ile Tyr Ser Ser Ser Glu Arg Ala Phe Cys Ala Gly
50 55 60
Gly Asp Val Arg Ala Val Arg Glu Ser Val Leu Glu Gly Asp Val Ala
65 70 75 80
Ala Gly Asp Lys Tyr Phe Ile Asp Glu Phe Ala Met Asn Asn Thr Leu
85 90 95
Gly Thr Tyr Pro Lys Pro Val Ile Ser Val Ile Asn Gly Val Ala Met
100 105 110
Gly Gly Gly Met Gly Ile Ser Met His Gly Ser His Arg Ile Val Thr
115 120 125
Glu Lys Ala Phe Ala Ser Met Pro Glu Met Ala Ile Gly Tyr Val Pro
130 135 140
Asp Val Gly Phe Thr Tyr Phe Gly Gln Arg Ala Ser Ser Leu Ala Ile
145 150 155 160
Ala Thr Phe Leu Ala Val Thr Gly Trp Arg Met Ser Pro Ala Asp Met
165 170 175
Leu Trp Ala Gly Val Ala Thr His Phe Val Glu Asp Ala Gln Gly Phe
180 185 190
Ile Asp Ala Val Leu Asn Glu Ser Leu Asp Gly Ala Leu Glu Lys Phe
195 200 205
Ser Thr Gln Pro Thr Gly Ser Ser Glu Leu Ala Gly Val Ala Ser Gln
210 215 220
Ile Glu Glu Thr Phe Gly His Ser Ser Trp Ala Leu Ile Asp Ala Ser
225 230 235 240
Leu Arg Ser His Pro Asp Ala Glu Phe Val Ala Lys Val Asp Gly Leu
245 250 255
Met Ala Ser Ala Ala Pro Ala Ser Val Val Ala Thr Val Lys Leu Met
260 265 270
His Gln Asn Ser Glu Ala Thr Thr Leu Arg Glu Gly Leu Asp Asn Glu
275 280 285
Leu Ala Met Ser Leu Tyr Met Ile Arg Gln Pro Asp Phe Ala Glu Gly
290 295 300
Val Arg Ala Val Leu Val Asp Lys Asp Arg Asn Ala Ala Phe Ser Pro
305 310 315 320
Ala Asn Tyr Glu Asp Val Asp Glu Ser His Phe Val Thr Leu Phe Gln
325 330 335
Arg Ser Ser
<210> 73
<211> 1086
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1063)
<223> RXN02512
<400> 73
gctggaaagt ccccattggc taaggaattt accaaggcac cagcaggtgc gaaggcagat 60
tacagcaaca ccaaataaaa attagccgag ggagcatcgc atg aag ccg aag gat 115
Met Lys Pro Lys Asp
1 5
ttc tgc aca gcg gaa aat tgg gcg gag aat tta agc gca ctg ggc tat 163
Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu Ser Ala Leu Gly Tyr
10 15 20
cta gct ggt tgg cgt ttt gtc cgg atg ctc cct ttg cct att gct cgc 211
Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro Leu Pro Ile Ala Arg
25 30 35
cgg gtg ttt gac ctt ggg gcg gat ctg gcg tcg aaa agc gga aaa ggc 259
Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser Lys Ser Gly Lys Gly
40 45 50
atg ggg cag cta cgc gct aat ctg gcg cgg gtg gtc ggt gcg gaa aac 307
Met Gly Gln Leu Arg Ala Asn Leu Ala Arg Val Val Gly Ala Glu Asn
55 60 65
gtt acg cag gcg ctg gtg aag caa gca acg cgc agc tat gcg cgg tat 355
Val Thr Gln Ala Leu Val Lys Gln Ala Thr Arg Ser Tyr Ala Arg Tyr
70 75 80 85
tgg ctg gaa gcg ttc cgg cta ccg gcg atc gcg cga gat cct gag ctg 403
Trp Leu Glu Ala Phe Arg Leu Pro Ala Ile Ala Arg Asp Pro Glu Leu
90 95 100
ctt gcg cgg ttg cgt aag gga act gtt ggc cta gat ttg ttg gat gaa 451
Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu Asp Leu Leu Asp Glu
105 110 115
tct ttg gct gcc ggc aag ggc gta gtt ttg acg ctc cca cac agc ggc 499
Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr Leu Pro His Ser Gly
120 125 130
aac tgg gat atg gct ggc gct ttt ctg att agc cat cat ggg caa ttc 547
Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser His His Gly Gln Phe
135 140 145
acc acc gtt gca gaa agg gtc aag ccg gaa cgc ttg ttt gaa gcg ttc 595
Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg Leu Phe Glu Ala Phe
150 155 160 165
gtg gag ttt cga gaa agc ctt gga ttt gag gtg ctg cct ctc acc ggt 643
Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val Leu Pro Leu Thr Gly
170 175 180
ggc gag cgt ccg ccg ttt gaa aag ctg aaa gag cgc ctg aca tct gga 691
Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu Arg Leu Thr Ser Gly
185 190 195
ggt atc gtg tgc ctt ctt ggg gag cgt gac ctg cgg cat tcc ggc gtg 739
Gly Ile Val Cys Leu Leu Gly Glu Arg Asp Leu Arg His Ser Gly Val
200 205 210
gag acc act ttt ttt ggt gag aag acc tcc atg cca gca gga cct gcg 787
Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met Pro Ala Gly Pro Ala
215 220 225
cag ctg gcc att gaa aca ggt gcg gcg ctg cac gtg gtg cat cca tgg 835
Gln Leu Ala Ile Glu Thr Gly Ala Ala Leu His Val Val His Pro Trp
230 235 240 245
ttc gat gac gac ggc tgg ggt ctc agc gta tcc gat gcc gtg acc gtg 883
Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser Asp Ala Val Thr Val
250 255 260
gat aat tta tcc gac acg gtg cag cgg atc gca cat ctt ttt atg gca 931
Asp Asn Leu Ser Asp Thr Val Gln Arg Ile Ala His Leu Phe Met Ala
265 270 275
aat att acg gcg cac ccc gct gat tgg cat atg ctc caa ccc ctg tgg 979
Asn Ile Thr Ala His Pro Ala Asp Trp His Met Leu Gln Pro Leu Trp
280 285 290
ttt ggt gat ttg gat ccg gag cgt ctc aag cgc tct agg gag cag aca 1027
Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg Ser Arg Glu Gln Thr
295 300 305
aat gtt cac aaa ccg gtg gca tta cag gag gac aat taggtgcgaa 1073
Asn Val His Lys Pro Val Ala Leu Gln Glu Asp Asn
310 315 320
ttggaatggt ctg 1086
<210> 74
<211> 321
<212> PRT
<213> Corynebacterium glutamicum
<400> 74
Met Lys Pro Lys Asp Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu
1 5 10 15
Ser Ala Leu Gly Tyr Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro
20 25 30
Leu Pro Ile Ala Arg Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser
35 40 45
Lys Ser Gly Lys Gly Met Gly Gln Leu Arg Ala Asn Leu Ala Arg Val
50 55 60
Val Gly Ala Glu Asn Val Thr Gln Ala Leu Val Lys Gln Ala Thr Arg
65 70 75 80
Ser Tyr Ala Arg Tyr Trp Leu Glu Ala Phe Arg Leu Pro Ala Ile Ala
85 90 95
Arg Asp Pro Glu Leu Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu
100 105 110
Asp Leu Leu Asp Glu Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr
115 120 125
Leu Pro His Ser Gly Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser
130 135 140
His His Gly Gln Phe Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg
145 150 155 160
Leu Phe Glu Ala Phe Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val
165 170 175
Leu Pro Leu Thr Gly Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu
180 185 190
Arg Leu Thr Ser Gly Gly Ile Val Cys Leu Leu Gly Glu Arg Asp Leu
195 200 205
Arg His Ser Gly Val Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met
210 215 220
Pro Ala Gly Pro Ala Gln Leu Ala Ile Glu Thr Gly Ala Ala Leu His
225 230 235 240
Val Val His Pro Trp Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser
245 250 255
Asp Ala Val Thr Val Asp Asn Leu Ser Asp Thr Val Gln Arg Ile Ala
260 265 270
His Leu Phe Met Ala Asn Ile Thr Ala His Pro Ala Asp Trp His Met
275 280 285
Leu Gln Pro Leu Trp Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg
290 295 300
Ser Arg Glu Gln Thr Asn Val His Lys Pro Val Ala Leu Gln Glu Asp
305 310 315 320
Asn
<210> 75
<211> 1057
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1057)
<223> FRXA02512
<400> 75
gctggaaagt ccccattggc taaggaattt accaaggcac cagcaggtgc gaaggcagat 60
tacagcaaca ccaaataaaa attagccgag ggagcatcgc atg aag ccg aag gat 115
Met Lys Pro Lys Asp
1 5
ttc tgc aca gcg gaa aat tgg gcg gag aat tta agc gca ctg ggc tat 163
Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu Ser Ala Leu Gly Tyr
10 15 20
cta gct ggt tgg cgt ttt gtc cgg atg ctc cct ttg cct att gct cgc 211
Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro Leu Pro Ile Ala Arg
25 30 35
cgg gtg ttt gac ctt ggg gcg gat ctg gcg tcg aaa agc gga aaa ggc 259
Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser Lys Ser Gly Lys Gly
40 45 50
atg ggg cag cta cgc gct aat ctg gcg cgg gtg gtc ggt gcg gaa aac 307
Met Gly Gln Leu Arg Ala Asn Leu Ala Arg Val Val Gly Ala Glu Asn
55 60 65
gtt acg cag gcg ctg gtg aag caa gca acg cgc agc tat gcg cgg tat 355
Val Thr Gln Ala Leu Val Lys Gln Ala Thr Arg Ser Tyr Ala Arg Tyr
70 75 80 85
tgg ctg gaa gcg ttc cgg cta ccg gcg atc gcg cga gat cct gag ctg 403
Trp Leu Glu Ala Phe Arg Leu Pro Ala Ile Ala Arg Asp Pro Glu Leu
90 95 100
ctt gcg cgg ttg cgt aag gga act gtt ggc cta gat ttg ttg gat gaa 451
Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu Asp Leu Leu Asp Glu
105 110 115
tct ttg gct gcc ggc aag ggc gta gtt ttg acg ctc cca cac agc ggc 499
Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr Leu Pro His Ser Gly
120 125 130
aac tgg gat atg gct ggc gct ttt ctg att agc cat cat ggg caa ttc 547
Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser His His Gly Gln Phe
135 140 145
acc acc gtt gca gaa agg gtc aag ccg gaa cgc ttg ttt gaa gcg ttc 595
Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg Leu Phe Glu Ala Phe
150 155 160 165
gtg gag ttt cga gaa agc ctt gga ttt gag gtg ctg cct ctc acc ggt 643
Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val Leu Pro Leu Thr Gly
170 175 180
ggc gag cgt ccg ccg ttt gaa aag ctg aaa gag cgc ctg aca tct gga 691
Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu Arg Leu Thr Ser Gly
185 190 195
ggt atc gtg tgc ctt ctt ggg gag cgt gac ctg cgg cat tcc ggc gtg 739
Gly Ile Val Cys Leu Leu Gly Glu Arg Asp Leu Arg His Ser Gly Val
200 205 210
gag acc act ttt ttt ggt gag aag acc tcc atg cca gca gga cct gcg 787
Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met Pro Ala Gly Pro Ala
215 220 225
cag ctg gcc att gaa aca ggt gcg gcg ctg cac gtg gtg cat cca tgg 835
Gln Leu Ala Ile Glu Thr Gly Ala Ala Leu His Val Val His Pro Trp
230 235 240 245
ttc gat gac gac ggc tgg ggt ctc agc gta tcc gat gcc gtg acc gtg 883
Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser Asp Ala Val Thr Val
250 255 260
gat aat tta tcc gac acg gtg cag cgg atc gca cat ctt ttt atg gca 931
Asp Asn Leu Ser Asp Thr Val Gln Arg Ile Ala His Leu Phe Met Ala
265 270 275
aat att acg gcg cac ccc gct gat tgg cat atg ctc caa ccc ctg tgg 979
Asn Ile Thr Ala His Pro Ala Asp Trp His Met Leu Gln Pro Leu Trp
280 285 290
ttt ggt gat ttg gat ccg gag cgt ctc aag cgc tct agg gag cag aca 1027
Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg Ser Arg Glu Gln Thr
295 300 305
aat gtt cac aaa ccg gtg gca tta cag gag 1057
Asn Val His Lys Pro Val Ala Leu Gln Glu
310 315
<210> 76
<211> 319
<212> PRT
<213> Corynebacterium glutamicum
<400> 76
Met Lys Pro Lys Asp Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu
1 5 10 15
Ser Ala Leu Gly Tyr Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro
20 25 30
Leu Pro Ile Ala Arg Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser
35 40 45
Lys Ser Gly Lys Gly Met Gly Gln Leu Arg Ala Asn Leu Ala Arg Val
50 55 60
Val Gly Ala Glu Asn Val Thr Gln Ala Leu Val Lys Gln Ala Thr Arg
65 70 75 80
Ser Tyr Ala Arg Tyr Trp Leu Glu Ala Phe Arg Leu Pro Ala Ile Ala
85 90 95
Arg Asp Pro Glu Leu Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu
100 105 110
Asp Leu Leu Asp Glu Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr
115 120 125
Leu Pro His Ser Gly Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser
130 135 140
His His Gly Gln Phe Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg
145 150 155 160
Leu Phe Glu Ala Phe Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val
165 170 175
Leu Pro Leu Thr Gly Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu
180 185 190
Arg Leu Thr Ser Gly Gly Ile Val Cys Leu Leu Gly Glu Arg Asp Leu
195 200 205
Arg His Ser Gly Val Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met
210 215 220
Pro Ala Gly Pro Ala Gln Leu Ala Ile Glu Thr Gly Ala Ala Leu His
225 230 235 240
Val Val His Pro Trp Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser
245 250 255
Asp Ala Val Thr Val Asp Asn Leu Ser Asp Thr Val Gln Arg Ile Ala
260 265 270
His Leu Phe Met Ala Asn Ile Thr Ala His Pro Ala Asp Trp His Met
275 280 285
Leu Gln Pro Leu Trp Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg
290 295 300
Ser Arg Glu Gln Thr Asn Val His Lys Pro Val Ala Leu Gln Glu
305 310 315
<210> 77
<211> 1389
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1366)
<223> RXA00899
<400> 77
tttgctgctc ccctacgtcg gactcccact gttcctgctt atgggatcgc catacatcaa 60
ccggtgacgc caccgcatcc aacaagaaat caacgacctc atg gaa gac gtc cac 115
Met Glu Asp Val His
1 5
gac gac gtc ccc gac atc ccc acc gga atg gat gtc tcc gcg gaa gtt 163
Asp Asp Val Pro Asp Ile Pro Thr Gly Met Asp Val Ser Ala Glu Val
10 15 20
gaa tct gtc atc aaa ctc aac cgc cgc ctc acc cgc atg cca gca gtg 211
Glu Ser Val Ile Lys Leu Asn Arg Arg Leu Thr Arg Met Pro Ala Val
25 30 35
acc ggc gga aac aac ggc ttc tac tcc gac tac cgt gaa tcc ctc aaa 259
Thr Gly Gly Asn Asn Gly Phe Tyr Ser Asp Tyr Arg Glu Ser Leu Lys
40 45 50
cgg atg acc gcc gca atc gac gaa gcc gaa gaa tac atc tac gtc gag 307
Arg Met Thr Ala Ala Ile Asp Glu Ala Glu Glu Tyr Ile Tyr Val Glu
55 60 65
atc tac atc atg gcc tgg gat tcc tac acc caa cca ttc ttc gca gca 355
Ile Tyr Ile Met Ala Trp Asp Ser Tyr Thr Gln Pro Phe Phe Ala Ala
70 75 80 85
ctc gaa cga gcc cac aac cgc ggc gtc aaa gtc cga ctc ctt ttc gac 403
Leu Glu Arg Ala His Asn Arg Gly Val Lys Val Arg Leu Leu Phe Asp
90 95 100
cac gtc ggc agc tgg aaa tac ccc ggc tac cac cgc ctc aaa aaa gaa 451
His Val Gly Ser Trp Lys Tyr Pro Gly Tyr His Arg Leu Lys Lys Glu
105 110 115
ctc aac cgc atg ggc ttc gcc tgg tac ctc atg ctc ccc ctc caa ccc 499
Leu Asn Arg Met Gly Phe Ala Trp Tyr Leu Met Leu Pro Leu Gln Pro
120 125 130
tgg cga cgc cgc ttc cgc cga ccc gac ctg cgc aac cac cgc aaa atg 547
Trp Arg Arg Arg Phe Arg Arg Pro Asp Leu Arg Asn His Arg Lys Met
135 140 145
ctc atc atc gac ggc cac acc gca ttc atg ggc tcc caa aat ctc atc 595
Leu Ile Ile Asp Gly His Thr Ala Phe Met Gly Ser Gln Asn Leu Ile
150 155 160 165
gcc ccg agt tac cta caa aag aaa aac atc aaa ctc ggc cgc gaa tgg 643
Ala Pro Ser Tyr Leu Gln Lys Lys Asn Ile Lys Leu Gly Arg Glu Trp
170 175 180
aaa gac ctc atg gtc gaa ctc acc ggc ccc atc gtc tcc tcc atg gaa 691
Lys Asp Leu Met Val Glu Leu Thr Gly Pro Ile Val Ser Ser Met Glu
185 190 195
atg atc ttc gcc ggc gac tgg tac gtc gaa tcc aac gaa gcc ctc gac 739
Met Ile Phe Ala Gly Asp Trp Tyr Val Glu Ser Asn Glu Ala Leu Asp
200 205 210
atc cgc gac cac gca gaa gcc cac ggc tac atc ggc aac act caa aaa 787
Ile Arg Asp His Ala Glu Ala His Gly Tyr Ile Gly Asn Thr Gln Lys
215 220 225
gac tcc gcc acc aac ctc gtg cag ctc atc ccc tcc ggc cct ggt tac 835
Asp Ser Ala Thr Asn Leu Val Gln Leu Ile Pro Ser Gly Pro Gly Tyr
230 235 240 245
acc aca gaa ccc aac ctg cgc atg ttc aac tcc atc gtt cac cac gcc 883
Thr Thr Glu Pro Asn Leu Arg Met Phe Asn Ser Ile Val His His Ala
250 255 260
aaa gaa cga ctc atc ttg tgc agc ccc tac ttc atc ccc gac gaa tcc 931
Lys Glu Arg Leu Ile Leu Cys Ser Pro Tyr Phe Ile Pro Asp Glu Ser
265 270 275
ctc ctc gaa gcc gtc acc tca gcc tgc tac cgc gga gta acc gtc gaa 979
Leu Leu Glu Ala Val Thr Ser Ala Cys Tyr Arg Gly Val Thr Val Glu
280 285 290
cta ttc gtc tct gaa caa gcc gac caa ttc gcc atc gac cac gcc caa 1027
Leu Phe Val Ser Glu Gln Ala Asp Gln Phe Ala Ile Asp His Ala Gln
295 300 305
tcc tcc tac tac cag gca ctc ctt gaa gcc ggc gtg aaa atc tac caa 1075
Ser Ser Tyr Tyr Gln Ala Leu Leu Glu Ala Gly Val Lys Ile Tyr Gln
310 315 320 325
ttc ccc aaa ccc gac gtc ctc cac acc aag tac atg atc gcc gac ccc 1123
Phe Pro Lys Pro Asp Val Leu His Thr Lys Tyr Met Ile Ala Asp Pro
330 335 340
gac gac acc acc ggc aac gaa gcc ctc gga gtc ctc gga tcc tcc aac 1171
Asp Asp Thr Thr Gly Asn Glu Ala Leu Gly Val Leu Gly Ser Ser Asn
345 350 355
ctc gac atc cgc agc ttt ggc ctc aac tac gaa atc tcc ctg atg atc 1219
Leu Asp Ile Arg Ser Phe Gly Leu Asn Tyr Glu Ile Ser Leu Met Ile
360 365 370
gcc aaa ggc aac ctc atc cac gaa ctc aac gcc ctc acc gac cgt tac 1267
Ala Lys Gly Asn Leu Ile His Glu Leu Asn Ala Leu Thr Asp Arg Tyr
375 380 385
cgc aca gta agt ttc aag ctc acc ttg gat aag tgg aac cag cgc agt 1315
Arg Thr Val Ser Phe Lys Leu Thr Leu Asp Lys Trp Asn Gln Arg Ser
390 395 400 405
tgg cgg cgc cgc tac gtg gac aat gtc atg cgt ttg acc tcg gcg ctg 1363
Trp Arg Arg Arg Tyr Val Asp Asn Val Met Arg Leu Thr Ser Ala Leu
410 415 420
cag tagtttggcg cgtttggagt gcg 1389
Gln
<210> 78
<211> 422
<212> PRT
<213> Corynebacterium glutamicum
<400> 78
Met Glu Asp Val His Asp Asp Val Pro Asp Ile Pro Thr Gly Met Asp
1 5 10 15
Val Ser Ala Glu Val Glu Ser Val Ile Lys Leu Asn Arg Arg Leu Thr
20 25 30
Arg Met Pro Ala Val Thr Gly Gly Asn Asn Gly Phe Tyr Ser Asp Tyr
35 40 45
Arg Glu Ser Leu Lys Arg Met Thr Ala Ala Ile Asp Glu Ala Glu Glu
50 55 60
Tyr Ile Tyr Val Glu Ile Tyr Ile Met Ala Trp Asp Ser Tyr Thr Gln
65 70 75 80
Pro Phe Phe Ala Ala Leu Glu Arg Ala His Asn Arg Gly Val Lys Val
85 90 95
Arg Leu Leu Phe Asp His Val Gly Ser Trp Lys Tyr Pro Gly Tyr His
100 105 110
Arg Leu Lys Lys Glu Leu Asn Arg Met Gly Phe Ala Trp Tyr Leu Met
115 120 125
Leu Pro Leu Gln Pro Trp Arg Arg Arg Phe Arg Arg Pro Asp Leu Arg
130 135 140
Asn His Arg Lys Met Leu Ile Ile Asp Gly His Thr Ala Phe Met Gly
145 150 155 160
Ser Gln Asn Leu Ile Ala Pro Ser Tyr Leu Gln Lys Lys Asn Ile Lys
165 170 175
Leu Gly Arg Glu Trp Lys Asp Leu Met Val Glu Leu Thr Gly Pro Ile
180 185 190
Val Ser Ser Met Glu Met Ile Phe Ala Gly Asp Trp Tyr Val Glu Ser
195 200 205
Asn Glu Ala Leu Asp Ile Arg Asp His Ala Glu Ala His Gly Tyr Ile
210 215 220
Gly Asn Thr Gln Lys Asp Ser Ala Thr Asn Leu Val Gln Leu Ile Pro
225 230 235 240
Ser Gly Pro Gly Tyr Thr Thr Glu Pro Asn Leu Arg Met Phe Asn Ser
245 250 255
Ile Val His His Ala Lys Glu Arg Leu Ile Leu Cys Ser Pro Tyr Phe
260 265 270
Ile Pro Asp Glu Ser Leu Leu Glu Ala Val Thr Ser Ala Cys Tyr Arg
275 280 285
Gly Val Thr Val Glu Leu Phe Val Ser Glu Gln Ala Asp Gln Phe Ala
290 295 300
Ile Asp His Ala Gln Ser Ser Tyr Tyr Gln Ala Leu Leu Glu Ala Gly
305 310 315 320
Val Lys Ile Tyr Gln Phe Pro Lys Pro Asp Val Leu His Thr Lys Tyr
325 330 335
Met Ile Ala Asp Pro Asp Asp Thr Thr Gly Asn Glu Ala Leu Gly Val
340 345 350
Leu Gly Ser Ser Asn Leu Asp Ile Arg Ser Phe Gly Leu Asn Tyr Glu
355 360 365
Ile Ser Leu Met Ile Ala Lys Gly Asn Leu Ile His Glu Leu Asn Ala
370 375 380
Leu Thr Asp Arg Tyr Arg Thr Val Ser Phe Lys Leu Thr Leu Asp Lys
385 390 395 400
Trp Asn Gln Arg Ser Trp Arg Arg Arg Tyr Val Asp Asn Val Met Arg
405 410 415
Leu Thr Ser Ala Leu Gln
420
<210> 79
<211> 1452
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1429)
<223> RXN00819
<220>
<221> misc_feature
<222> 1264
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 1267
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 1268
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 1279
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 1281
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 1285
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 1301
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 1304
<223> n indicates any nucleotide
<220>
<221> VARIANT
<222> 390
<223> Xaa = Ser, Pro, Thr, or Ala
<220>
<221> VARIANT
<222> 394
<223> Xaa = Leu, Pro, His, or Arg
<220>
<221> VARIANT
<222> 401
<223> Xaa = Tyr, His, Asn, or Asp
<220>
<221> VARIANT
<222> 402
<223> Xaa = Ser, Pro, Thr, or Ala
<400> 79
gatgaggttc gtccgggaat cctcaaagac aatgcggtga aggtacttgg cctagccgct 60
agcactgagc gcggatctca agcagaaaag gtcgtgcaac atg cgt gat ccc att 115
Met Arg Asp Pro Ile
1 5
caa ggt gct gtt att cct tct gat ctt ttt ggt ttc gca gaa gtt ctc 163
Gln Gly Ala Val Ile Pro Ser Asp Leu Phe Gly Phe Ala Glu Val Leu
10 15 20
acc gaa gcc gaa cgc gca gtt ctt ctg gaa acc cgc agg gtg ctt gag 211
Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr Arg Arg Val Leu Glu
25 30 35
gaa gag gtg aag cct tat att aat gag gcc tgg gat aag gca gtc ttc 259
Glu Glu Val Lys Pro Tyr Ile Asn Glu Ala Trp Asp Lys Ala Val Phe
40 45 50
ccc gat gag atc gtg cag ccc ctc caa gat ctg caa ttg ctt gat ccg 307
Pro Asp Glu Ile Val Gln Pro Leu Gln Asp Leu Gln Leu Leu Asp Pro
55 60 65
cct gca ctt cgg gaa gca ggg gag tcg gtt cga gac att ttc act ggt 355
Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg Asp Ile Phe Thr Gly
70 75 80 85
ttc cgc aat ttt gaa ctc gcg cgc tgt gac atc aat gtt ggt acc tat 403
Phe Arg Asn Phe Glu Leu Ala Arg Cys Asp Ile Asn Val Gly Thr Tyr
90 95 100
tac aac gca tct gct ggt ctc ttc cga acg gcc tgc atg gtt ggt ggc 451
Tyr Asn Ala Ser Ala Gly Leu Phe Arg Thr Ala Cys Met Val Gly Gly
105 110 115
tcc ccg gag cag gcg cag cga ttg gat gcg cag atc aaa tct ggt gag 499
Ser Pro Glu Gln Ala Gln Arg Leu Asp Ala Gln Ile Lys Ser Gly Glu
120 125 130
gtc aag ggc gtt ttt gca ctg acg gaa cct gat cat ggc tct gat atc 547
Val Lys Gly Val Phe Ala Leu Thr Glu Pro Asp His Gly Ser Asp Ile
135 140 145
gca ggt ggt ctg gca acc acg gcc act aag gac gca gac acc ggc gag 595
Ala Gly Gly Leu Ala Thr Thr Ala Thr Lys Asp Ala Asp Thr Gly Glu
150 155 160 165
tgg att atc aat ggt gaa aaa cgg tgg atc ggt ggt gct tcc act gct 643
Trp Ile Ile Asn Gly Glu Lys Arg Trp Ile Gly Gly Ala Ser Thr Ala
170 175 180
gat ttg atc gct acc ttc gcc agg gat aca gcc gat aac cag gtg aaa 691
Asp Leu Ile Ala Thr Phe Ala Arg Asp Thr Ala Asp Asn Gln Val Lys
185 190 195
tgc ttc ctc gtg gca cct cag gca gag ggc gtg tcc atg gag att att 739
Cys Phe Leu Val Ala Pro Gln Ala Glu Gly Val Ser Met Glu Ile Ile
200 205 210
gat cgc aaa gcc tca ctg cgc atc atg caa aat gca cac att acc tat 787
Asp Arg Lys Ala Ser Leu Arg Ile Met Gln Asn Ala His Ile Thr Tyr
215 220 225
aac aat gtc cgg gtg tct ggg gat gcg cgg ctg cac aac atc aat tct 835
Asn Asn Val Arg Val Ser Gly Asp Ala Arg Leu His Asn Ile Asn Ser
230 235 240 245
ttc aag gat gtt tcg gaa tgc ctg cgc cgt atg cgt tcc gat gtg gcg 883
Phe Lys Asp Val Ser Glu Cys Leu Arg Arg Met Arg Ser Asp Val Ala
250 255 260
tgg atg gcg gtc ggt gcg cag gca ggt gcc tat gaa gca gcc gtg aag 931
Trp Met Ala Val Gly Ala Gln Ala Gly Ala Tyr Glu Ala Ala Val Lys
265 270 275
tat gtg cgc agc agg gaa cag ttt ggc cgt ccg atc gcg ggg ttc cag 979
Tyr Val Arg Ser Arg Glu Gln Phe Gly Arg Pro Ile Ala Gly Phe Gln
280 285 290
ttg att cag gaa aag ctc gcg ctc atg ctg ggc aat ctc acg gcg tcg 1027
Leu Ile Gln Glu Lys Leu Ala Leu Met Leu Gly Asn Leu Thr Ala Ser
295 300 305
ctg ggc atg atg gtc aaa ctc acc gat cag cag cag gcg gga att ttc 1075
Leu Gly Met Met Val Lys Leu Thr Asp Gln Gln Gln Ala Gly Ile Phe
310 315 320 325
aaa gag gaa aac tcc gcg ctg gcg aaa atg ttt acc tcg ctc aaa ctt 1123
Lys Glu Glu Asn Ser Ala Leu Ala Lys Met Phe Thr Ser Leu Lys Leu
330 335 340
cgg gag acc gct agt tgg gcg cgg gaa atc tgc gga ggc aac ggc atc 1171
Arg Glu Thr Ala Ser Trp Ala Arg Glu Ile Cys Gly Gly Asn Gly Ile
345 350 355
att ttg gac aac gat gtt gcc cgg ttc cat gcc gat gca gaa gcc gtc 1219
Ile Leu Asp Asn Asp Val Ala Arg Phe His Ala Asp Ala Glu Ala Val
360 365 370
tat tca tat gaa ggc acc cac gaa atc aat gca ctc atc gtt ggn cgn 1267
Tyr Ser Tyr Glu Gly Thr His Glu Ile Asn Ala Leu Ile Val Gly Arg
375 380 385
ncc att ctg ggn cnt ctn ttc ttt tta tat tat nac nct ttt gag gag 1315
Xaa Ile Leu Gly Xaa Leu Phe Phe Leu Tyr Tyr Xaa Xaa Phe Glu Glu
390 395 400 405
gat ctt cat gac tac ttc cac cac ccc aaa cca tcg ttt ctt tcg aag 1363
Asp Leu His Asp Tyr Phe His His Pro Lys Pro Ser Phe Leu Ser Lys
410 415 420
acg cac caa ccc tca ccg gcc agg acc tgg gct ttt cgc agt ggc gca 1411
Thr His Gln Pro Ser Pro Ala Arg Thr Trp Ala Phe Arg Ser Gly Ala
425 430 435
ctg tca ccc agg aga tgg tgaacacctt ggcggacgca act 1452
Leu Ser Pro Arg Arg Trp
440
<210> 80
<211> 443
<212> PRT
<213> Corynebacterium glutamicum
<220>
<221> VARIANT
<222> 390
<223> Xaa = Ser, Pro, Thr, or Ala
<220>
<221> VARIANT
<222> 394
<223> Xaa = Leu, Pro, His, or Arg
<220>
<221> VARIANT
<222> 401
<223> Xaa = Tyr, His, Asn, or Asp
<220>
<221> VARIANT
<222> 402
<223> Xaa = Ser, Pro, Thr, or Ala
<400> 80
Met Arg Asp Pro Ile Gln Gly Ala Val Ile Pro Ser Asp Leu Phe Gly
1 5 10 15
Phe Ala Glu Val Leu Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr
20 25 30
Arg Arg Val Leu Glu Glu Glu Val Lys Pro Tyr Ile Asn Glu Ala Trp
35 40 45
Asp Lys Ala Val Phe Pro Asp Glu Ile Val Gln Pro Leu Gln Asp Leu
50 55 60
Gln Leu Leu Asp Pro Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg
65 70 75 80
Asp Ile Phe Thr Gly Phe Arg Asn Phe Glu Leu Ala Arg Cys Asp Ile
85 90 95
Asn Val Gly Thr Tyr Tyr Asn Ala Ser Ala Gly Leu Phe Arg Thr Ala
100 105 110
Cys Met Val Gly Gly Ser Pro Glu Gln Ala Gln Arg Leu Asp Ala Gln
115 120 125
Ile Lys Ser Gly Glu Val Lys Gly Val Phe Ala Leu Thr Glu Pro Asp
130 135 140
His Gly Ser Asp Ile Ala Gly Gly Leu Ala Thr Thr Ala Thr Lys Asp
145 150 155 160
Ala Asp Thr Gly Glu Trp Ile Ile Asn Gly Glu Lys Arg Trp Ile Gly
165 170 175
Gly Ala Ser Thr Ala Asp Leu Ile Ala Thr Phe Ala Arg Asp Thr Ala
180 185 190
Asp Asn Gln Val Lys Cys Phe Leu Val Ala Pro Gln Ala Glu Gly Val
195 200 205
Ser Met Glu Ile Ile Asp Arg Lys Ala Ser Leu Arg Ile Met Gln Asn
210 215 220
Ala His Ile Thr Tyr Asn Asn Val Arg Val Ser Gly Asp Ala Arg Leu
225 230 235 240
His Asn Ile Asn Ser Phe Lys Asp Val Ser Glu Cys Leu Arg Arg Met
245 250 255
Arg Ser Asp Val Ala Trp Met Ala Val Gly Ala Gln Ala Gly Ala Tyr
260 265 270
Glu Ala Ala Val Lys Tyr Val Arg Ser Arg Glu Gln Phe Gly Arg Pro
275 280 285
Ile Ala Gly Phe Gln Leu Ile Gln Glu Lys Leu Ala Leu Met Leu Gly
290 295 300
Asn Leu Thr Ala Ser Leu Gly Met Met Val Lys Leu Thr Asp Gln Gln
305 310 315 320
Gln Ala Gly Ile Phe Lys Glu Glu Asn Ser Ala Leu Ala Lys Met Phe
325 330 335
Thr Ser Leu Lys Leu Arg Glu Thr Ala Ser Trp Ala Arg Glu Ile Cys
340 345 350
Gly Gly Asn Gly Ile Ile Leu Asp Asn Asp Val Ala Arg Phe His Ala
355 360 365
Asp Ala Glu Ala Val Tyr Ser Tyr Glu Gly Thr His Glu Ile Asn Ala
370 375 380
Leu Ile Val Gly Arg Xaa Ile Leu Gly Xaa Leu Phe Phe Leu Tyr Tyr
385 390 395 400
Xaa Xaa Phe Glu Glu Asp Leu His Asp Tyr Phe His His Pro Lys Pro
405 410 415
Ser Phe Leu Ser Lys Thr His Gln Pro Ser Pro Ala Arg Thr Trp Ala
420 425 430
Phe Arg Ser Gly Ala Leu Ser Pro Arg Arg Trp
435 440
<210> 81
<211> 1030
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (18)..(1007)
<223> FRXA00819
<220>
<221> misc_feature
<222> 842
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 845
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 846
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 857
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 859
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 863
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 879
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 882
<223> n indicates any nucleotide
<220>
<221> VARIANT
<222> 277
<223> Xaa = Ser, Pro, Thr, or Ala
<220>
<221> VARIANT
<222> 281
<223> Xaa = Leu, Pro, His, or Arg
<220>
<221> VARIANT
<222> 288
<223> Xaa = Tyr, His, Asn, or Asp
<220>
<221> VARIANT
<222> 289
<223> Xaa = Ser, Pro, Thr, or Ala
<400> 81
tcttccgaac ggcctgc atg gtt ggt ggc tcc ccg gag cag gcg cag cga 50
Met Val Gly Gly Ser Pro Glu Gln Ala Gln Arg
1 5 10
ttg gat gcg cag atc aaa tct ggt gag gtc aag ggc gtt ttt gca ctg 98
Leu Asp Ala Gln Ile Lys Ser Gly Glu Val Lys Gly Val Phe Ala Leu
15 20 25
acg gaa cct gat cat ggc tct gat atc gca ggt ggt ctg gca acc acg 146
Thr Glu Pro Asp His Gly Ser Asp Ile Ala Gly Gly Leu Ala Thr Thr
30 35 40
gcc act aag gac gca gac acc ggc gag tgg att atc aat ggt gaa aaa 194
Ala Thr Lys Asp Ala Asp Thr Gly Glu Trp Ile Ile Asn Gly Glu Lys
45 50 55
cgg tgg atc ggt ggt gct tcc act gct gat ttg atc gct acc ttc gcc 242
Arg Trp Ile Gly Gly Ala Ser Thr Ala Asp Leu Ile Ala Thr Phe Ala
60 65 70 75
agg gat aca gcc gat aac cag gtg aaa tgc ttc ctc gtg gca cct cag 290
Arg Asp Thr Ala Asp Asn Gln Val Lys Cys Phe Leu Val Ala Pro Gln
80 85 90
gca gag ggc gtg tcc atg gag att att gat cgc aaa gcc tca ctg cgc 338
Ala Glu Gly Val Ser Met Glu Ile Ile Asp Arg Lys Ala Ser Leu Arg
95 100 105
atc atg caa aat gca cac att acc tat aac aat gtc cgg gtg tct ggg 386
Ile Met Gln Asn Ala His Ile Thr Tyr Asn Asn Val Arg Val Ser Gly
110 115 120
gat gcg cgg ctg cac aac atc aat tct ttc aag gat gtt tcg gaa tgc 434
Asp Ala Arg Leu His Asn Ile Asn Ser Phe Lys Asp Val Ser Glu Cys
125 130 135
ctg cgc cgt atg cgt tcc gat gtg gcg tgg atg gcg gtc ggt gcg cag 482
Leu Arg Arg Met Arg Ser Asp Val Ala Trp Met Ala Val Gly Ala Gln
140 145 150 155
gca ggt gcc tat gaa gca gcc gtg aag tat gtg cgc agc agg gaa cag 530
Ala Gly Ala Tyr Glu Ala Ala Val Lys Tyr Val Arg Ser Arg Glu Gln
160 165 170
ttt ggc cgt ccg atc gcg ggg ttc cag ttg att cag gaa aag ctc gcg 578
Phe Gly Arg Pro Ile Ala Gly Phe Gln Leu Ile Gln Glu Lys Leu Ala
175 180 185
ctc atg ctg ggc aat ctc acg gcg tcg ctg ggc atg atg gtc aaa ctc 626
Leu Met Leu Gly Asn Leu Thr Ala Ser Leu Gly Met Met Val Lys Leu
190 195 200
acc gat cag cag cag gcg gga att ttc aaa gag gaa aac tcc gcg ctg 674
Thr Asp Gln Gln Gln Ala Gly Ile Phe Lys Glu Glu Asn Ser Ala Leu
205 210 215
gcg aaa atg ttt acc tcg ctc aaa ctt cgg gag acc gct agt tgg gcg 722
Ala Lys Met Phe Thr Ser Leu Lys Leu Arg Glu Thr Ala Ser Trp Ala
220 225 230 235
cgg gaa atc tgc gga ggc aac ggc atc att ttg gac aac gat gtt gcc 770
Arg Glu Ile Cys Gly Gly Asn Gly Ile Ile Leu Asp Asn Asp Val Ala
240 245 250
cgg ttc cat gcc gat gca gaa gcc gtc tat tca tat gaa ggc acc cac 818
Arg Phe His Ala Asp Ala Glu Ala Val Tyr Ser Tyr Glu Gly Thr His
255 260 265
gaa atc aat gca ctc atc gtt ggn cgn ncc att ctg ggn cnt ctn ttc 866
Glu Ile Asn Ala Leu Ile Val Gly Arg Xaa Ile Leu Gly Xaa Leu Phe
270 275 280
ttt tta tat tat nac nct ttt gag gag gat ctt cat gac tac ttc cac 914
Phe Leu Tyr Tyr Xaa Xaa Phe Glu Glu Asp Leu His Asp Tyr Phe His
285 290 295
cac ccc aaa cca tcg ttt ctt tcg aag acg cac caa ccc tca ccg gcc 962
His Pro Lys Pro Ser Phe Leu Ser Lys Thr His Gln Pro Ser Pro Ala
300 305 310 315
agg acc tgg gct ttt cgc agt ggc gca ctg tca ccc agg aga tgg 1007
Arg Thr Trp Ala Phe Arg Ser Gly Ala Leu Ser Pro Arg Arg Trp
320 325 330
tgaacacctt cgcggacgca act 1030
<210> 82
<211> 330
<212> PRT
<213> Corynebacterium glutamicum
<220>
<221> VARIANT
<222> 277
<223> Xaa = Ser, Pro, Thr, or Ala
<220>
<221> VARIANT
<222> 281
<223> Xaa = Leu, Pro, His, or Arg
<220>
<221> VARIANT
<222> 288
<223> Xaa = Tyr, His, Asn, or Asp
<220>
<221> VARIANT
<222> 289
<223> Xaa = Ser, Pro, Thr, or Ala
<400> 82
Met Val Gly Gly Ser Pro Glu Gln Ala Gln Arg Leu Asp Ala Gln Ile
1 5 10 15
Lys Ser Gly Glu Val Lys Gly Val Phe Ala Leu Thr Glu Pro Asp His
20 25 30
Gly Ser Asp Ile Ala Gly Gly Leu Ala Thr Thr Ala Thr Lys Asp Ala
35 40 45
Asp Thr Gly Glu Trp Ile Ile Asn Gly Glu Lys Arg Trp Ile Gly Gly
50 55 60
Ala Ser Thr Ala Asp Leu Ile Ala Thr Phe Ala Arg Asp Thr Ala Asp
65 70 75 80
Asn Gln Val Lys Cys Phe Leu Val Ala Pro Gln Ala Glu Gly Val Ser
85 90 95
Met Glu Ile Ile Asp Arg Lys Ala Ser Leu Arg Ile Met Gln Asn Ala
100 105 110
His Ile Thr Tyr Asn Asn Val Arg Val Ser Gly Asp Ala Arg Leu His
115 120 125
Asn Ile Asn Ser Phe Lys Asp Val Ser Glu Cys Leu Arg Arg Met Arg
130 135 140
Ser Asp Val Ala Trp Met Ala Val Gly Ala Gln Ala Gly Ala Tyr Glu
145 150 155 160
Ala Ala Val Lys Tyr Val Arg Ser Arg Glu Gln Phe Gly Arg Pro Ile
165 170 175
Ala Gly Phe Gln Leu Ile Gln Glu Lys Leu Ala Leu Met Leu Gly Asn
180 185 190
Leu Thr Ala Ser Leu Gly Met Met Val Lys Leu Thr Asp Gln Gln Gln
195 200 205
Ala Gly Ile Phe Lys Glu Glu Asn Ser Ala Leu Ala Lys Met Phe Thr
210 215 220
Ser Leu Lys Leu Arg Glu Thr Ala Ser Trp Ala Arg Glu Ile Cys Gly
225 230 235 240
Gly Asn Gly Ile Ile Leu Asp Asn Asp Val Ala Arg Phe His Ala Asp
245 250 255
Ala Glu Ala Val Tyr Ser Tyr Glu Gly Thr His Glu Ile Asn Ala Leu
260 265 270
Ile Val Gly Arg Xaa Ile Leu Gly Xaa Leu Phe Phe Leu Tyr Tyr Xaa
275 280 285
Xaa Phe Glu Glu Asp Leu His Asp Tyr Phe His His Pro Lys Pro Ser
290 295 300
Phe Leu Ser Lys Thr His Gln Pro Ser Pro Ala Arg Thr Trp Ala Phe
305 310 315 320
Arg Ser Gly Ala Leu Ser Pro Arg Arg Trp
325 330
<210> 83
<211> 391
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(391)
<223> FRXA01766
<400> 83
gatgaggttc gtccgggaat cctcaaagac aatgcggtga aggtacttgg cctagccgct 60
agcactgagc gcggatctca agcagaaaag gtcgtgcaac atg cgt gat ccc att 115
Met Arg Asp Pro Ile
1 5
caa ggt gct gtt att cct tct gat ctt ttt ggt ttc gca gaa gtt ctc 163
Gln Gly Ala Val Ile Pro Ser Asp Leu Phe Gly Phe Ala Glu Val Leu
10 15 20
acc gaa gcc gaa cgc gca gtt ctt ctg gaa acc cgc agg gtg ctt gag 211
Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr Arg Arg Val Leu Glu
25 30 35
gaa gag gtg aag cct tat att aat gag gcc tgg gat aag gca gtc ttc 259
Glu Glu Val Lys Pro Tyr Ile Asn Glu Ala Trp Asp Lys Ala Val Phe
40 45 50
ccc gat gag atc gtg cag ccc ctc caa gat ctg caa ttg ctt gat ccg 307
Pro Asp Glu Ile Val Gln Pro Leu Gln Asp Leu Gln Leu Leu Asp Pro
55 60 65
cct gca ctt cgg gaa gca ggg gag tcg gtt cga gac att ttc act ggt 355
Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg Asp Ile Phe Thr Gly
70 75 80 85
ttc cgc aat ttt gaa ctc gcg cgc tgt gac atc aat 391
Phe Arg Asn Phe Glu Leu Ala Arg Cys Asp Ile Asn
90 95
<210> 84
<211> 97
<212> PRT
<213> Corynebacterium glutamicum
<400> 84
Met Arg Asp Pro Ile Gln Gly Ala Val Ile Pro Ser Asp Leu Phe Gly
1 5 10 15
Phe Ala Glu Val Leu Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr
20 25 30
Arg Arg Val Leu Glu Glu Glu Val Lys Pro Tyr Ile Asn Glu Ala Trp
35 40 45
Asp Lys Ala Val Phe Pro Asp Glu Ile Val Gln Pro Leu Gln Asp Leu
50 55 60
Gln Leu Leu Asp Pro Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg
65 70 75 80
Asp Ile Phe Thr Gly Phe Arg Asn Phe Glu Leu Ala Arg Cys Asp Ile
85 90 95
Asn
<210> 85
<211> 1659
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1636)
<223> RXN01762
<400> 85
tggagtgatg aattttccta tagaacgttt tttaaacgat tgacttttta aacgtttacg 60
cttttaatga cttcaaacgt gatctaaagc acaaaggaga atg aaa gtg aac ctc 115
Met Lys Val Asn Leu
1 5
gga ata gga agc tac cca cga cgc agg gca act gtt cga cca gag tcc 163
Gly Ile Gly Ser Tyr Pro Arg Arg Arg Ala Thr Val Arg Pro Glu Ser
10 15 20
act gca atc gaa ttc gaa ggc acc agc atc acc tac gga gaa ttc agc 211
Thr Ala Ile Glu Phe Glu Gly Thr Ser Ile Thr Tyr Gly Glu Phe Ser
25 30 35
aaa cga gtc aat cgg ctt gga cat gct ctt cta gac ctc ggc gtt gcg 259
Lys Arg Val Asn Arg Leu Gly His Ala Leu Leu Asp Leu Gly Val Ala
40 45 50
cac caa gat cga gta gct tat gtc gga ttc aac cac cct gcc ctg cta 307
His Gln Asp Arg Val Ala Tyr Val Gly Phe Asn His Pro Ala Leu Leu
55 60 65
gaa gtg ttc ttt tca acg aac ctc att ggg gca aca ccc gtg ctt gtt 355
Glu Val Phe Phe Ser Thr Asn Leu Ile Gly Ala Thr Pro Val Leu Val
70 75 80 85
aac cct cgc cta tcg gca aac gaa atc gat tac atc atc caa gac agc 403
Asn Pro Arg Leu Ser Ala Asn Glu Ile Asp Tyr Ile Ile Gln Asp Ser
90 95 100
ggt gcg agc atc gtg ttt tac gga atc gac ctc atc gag cac gcc act 451
Gly Ala Ser Ile Val Phe Tyr Gly Ile Asp Leu Ile Glu His Ala Thr
105 110 115
tac ctc caa gaa ctc cat cca gag atc atc atg gtg gcc gtt gaa ggc 499
Tyr Leu Gln Glu Leu His Pro Glu Ile Ile Met Val Ala Val Glu Gly
120 125 130
gat gag ggt cca ggt ttg cgt cga aaa gcg ctt att gaa gcg gcg agc 547
Asp Glu Gly Pro Gly Leu Arg Arg Lys Ala Leu Ile Glu Ala Ala Ser
135 140 145
gac gcc gac atc gac cta gaa gtc agc gat gat gac ctg gtg ctg ctc 595
Asp Ala Asp Ile Asp Leu Glu Val Ser Asp Asp Asp Leu Val Leu Leu
150 155 160 165
atg tac acc tcc gga acc act ggc cgc cca aag ggc gcc atg tta tcc 643
Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Ala Met Leu Ser
170 175 180
cac cga aac ctc ttc ttt aac tac ttc aat gcc ctg ctc agc cag gaa 691
His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Ala Leu Leu Ser Gln Glu
185 190 195
att gaa caa ggc gcg gta ctt tta tcc act gcg ccg tta ttc cac atc 739
Ile Glu Gln Gly Ala Val Leu Leu Ser Thr Ala Pro Leu Phe His Ile
200 205 210
gcg ggc ctc aac atg acc acc atc ccg gtg atg atg aag ggc gga aag 787
Ala Gly Leu Asn Met Thr Thr Ile Pro Val Met Met Lys Gly Gly Lys
215 220 225
gtg atc atc cac cgc gaa ttc cgg gca gag cac gtc ctc gac gaa atc 835
Val Ile Ile His Arg Glu Phe Arg Ala Glu His Val Leu Asp Glu Ile
230 235 240 245
gaa cgc tcc aag gta tcc gaa tcc ttc atg gtg cca gcg atg atc gac 883
Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val Pro Ala Met Ile Asp
250 255 260
atg ttg tcc aac cac cca tca ttt gcc gaa cgc gac ctt tct tcc ctt 931
Met Leu Ser Asn His Pro Ser Phe Ala Glu Arg Asp Leu Ser Ser Leu
265 270 275
cgc gcc atc atg gtg ggc ggc tct ccc ctt agc gaa cgt gcg ctg cga 979
Arg Ala Ile Met Val Gly Gly Ser Pro Leu Ser Glu Arg Ala Leu Arg
280 285 290
atc tgg caa gga cgc gac gta aaa att gtc caa ggc ttc ggc atg aca 1027
Ile Trp Gln Gly Arg Asp Val Lys Ile Val Gln Gly Phe Gly Met Thr
295 300 305
gaa acc gca ccg ggc gcc tgt atc ctc gag gca aca gac aca agc aca 1075
Glu Thr Ala Pro Gly Ala Cys Ile Leu Glu Ala Thr Asp Thr Ser Thr
310 315 320 325
cac ctt gga acc gca ggt cga gcc cac ttc ttc acc gac atc aaa cta 1123
His Leu Gly Thr Ala Gly Arg Ala His Phe Phe Thr Asp Ile Lys Leu
330 335 340
gtg gac ccg aaa acc ggc gaa gaa gtc ccc acc gga gag gcc ggc gaa 1171
Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr Gly Glu Ala Gly Glu
345 350 355
gtt ctc atc cgc gga cca cat gtg atg acc gga tac tgg aac cga cca 1219
Val Leu Ile Arg Gly Pro His Val Met Thr Gly Tyr Trp Asn Arg Pro
360 365 370
gaa gac acc gcc agc gca cta caa aat ggc tgg tac cac tcc gga gat 1267
Glu Asp Thr Ala Ser Ala Leu Gln Asn Gly Trp Tyr His Ser Gly Asp
375 380 385
atc gcc atc aaa gat gaa gac ggc tac tac acc atc aaa gac cgc atc 1315
Ile Ala Ile Lys Asp Glu Asp Gly Tyr Tyr Thr Ile Lys Asp Arg Ile
390 395 400 405
aaa gac atg tac atc tcc ggc ggc gaa aac att tac ccc gca gaa gtc 1363
Lys Asp Met Tyr Ile Ser Gly Gly Glu Asn Ile Tyr Pro Ala Glu Val
410 415 420
gaa caa gca ctc cag gaa ctg gaa gca gtc ctt gat gcc gca gtc atc 1411
Glu Gln Ala Leu Gln Glu Leu Glu Ala Val Leu Asp Ala Ala Val Ile
425 430 435
gga gtc ccc gat gaa cga tgg ggc gaa act ggc atc gcc ttt gtc tcc 1459
Gly Val Pro Asp Glu Arg Trp Gly Glu Thr Gly Ile Ala Phe Val Ser
440 445 450
atc cga gaa agc tac ctg acc aac cca cca acc gga ccg gaa cta cga 1507
Ile Arg Glu Ser Tyr Leu Thr Asn Pro Pro Thr Gly Pro Glu Leu Arg
455 460 465
gaa cta cta ggc agt gtc cta gcc aga tac aaa ctt cca cga gaa atc 1555
Glu Leu Leu Gly Ser Val Leu Ala Arg Tyr Lys Leu Pro Arg Glu Ile
470 475 480 485
cac atc atc gaa gaa ctc ccc cgc aac gcc aca ggc aaa atc caa aag 1603
His Ile Ile Glu Glu Leu Pro Arg Asn Ala Thr Gly Lys Ile Gln Lys
490 495 500
aac atc ctg cga gac ttc acc atc ccc gtt tca taaacccccc aacgtcactt 1656
Asn Ile Leu Arg Asp Phe Thr Ile Pro Val Ser
505 510
tga 1659
<210> 86
<211> 512
<212> PRT
<213> Corynebacterium glutamicum
<400> 86
Met Lys Val Asn Leu Gly Ile Gly Ser Tyr Pro Arg Arg Arg Ala Thr
1 5 10 15
Val Arg Pro Glu Ser Thr Ala Ile Glu Phe Glu Gly Thr Ser Ile Thr
20 25 30
Tyr Gly Glu Phe Ser Lys Arg Val Asn Arg Leu Gly His Ala Leu Leu
35 40 45
Asp Leu Gly Val Ala His Gln Asp Arg Val Ala Tyr Val Gly Phe Asn
50 55 60
His Pro Ala Leu Leu Glu Val Phe Phe Ser Thr Asn Leu Ile Gly Ala
65 70 75 80
Thr Pro Val Leu Val Asn Pro Arg Leu Ser Ala Asn Glu Ile Asp Tyr
85 90 95
Ile Ile Gln Asp Ser Gly Ala Ser Ile Val Phe Tyr Gly Ile Asp Leu
100 105 110
Ile Glu His Ala Thr Tyr Leu Gln Glu Leu His Pro Glu Ile Ile Met
115 120 125
Val Ala Val Glu Gly Asp Glu Gly Pro Gly Leu Arg Arg Lys Ala Leu
130 135 140
Ile Glu Ala Ala Ser Asp Ala Asp Ile Asp Leu Glu Val Ser Asp Asp
145 150 155 160
Asp Leu Val Leu Leu Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys
165 170 175
Gly Ala Met Leu Ser His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Ala
180 185 190
Leu Leu Ser Gln Glu Ile Glu Gln Gly Ala Val Leu Leu Ser Thr Ala
195 200 205
Pro Leu Phe His Ile Ala Gly Leu Asn Met Thr Thr Ile Pro Val Met
210 215 220
Met Lys Gly Gly Lys Val Ile Ile His Arg Glu Phe Arg Ala Glu His
225 230 235 240
Val Leu Asp Glu Ile Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val
245 250 255
Pro Ala Met Ile Asp Met Leu Ser Asn His Pro Ser Phe Ala Glu Arg
260 265 270
Asp Leu Ser Ser Leu Arg Ala Ile Met Val Gly Gly Ser Pro Leu Ser
275 280 285
Glu Arg Ala Leu Arg Ile Trp Gln Gly Arg Asp Val Lys Ile Val Gln
290 295 300
Gly Phe Gly Met Thr Glu Thr Ala Pro Gly Ala Cys Ile Leu Glu Ala
305 310 315 320
Thr Asp Thr Ser Thr His Leu Gly Thr Ala Gly Arg Ala His Phe Phe
325 330 335
Thr Asp Ile Lys Leu Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr
340 345 350
Gly Glu Ala Gly Glu Val Leu Ile Arg Gly Pro His Val Met Thr Gly
355 360 365
Tyr Trp Asn Arg Pro Glu Asp Thr Ala Ser Ala Leu Gln Asn Gly Trp
370 375 380
Tyr His Ser Gly Asp Ile Ala Ile Lys Asp Glu Asp Gly Tyr Tyr Thr
385 390 395 400
Ile Lys Asp Arg Ile Lys Asp Met Tyr Ile Ser Gly Gly Glu Asn Ile
405 410 415
Tyr Pro Ala Glu Val Glu Gln Ala Leu Gln Glu Leu Glu Ala Val Leu
420 425 430
Asp Ala Ala Val Ile Gly Val Pro Asp Glu Arg Trp Gly Glu Thr Gly
435 440 445
Ile Ala Phe Val Ser Ile Arg Glu Ser Tyr Leu Thr Asn Pro Pro Thr
450 455 460
Gly Pro Glu Leu Arg Glu Leu Leu Gly Ser Val Leu Ala Arg Tyr Lys
465 470 475 480
Leu Pro Arg Glu Ile His Ile Ile Glu Glu Leu Pro Arg Asn Ala Thr
485 490 495
Gly Lys Ile Gln Lys Asn Ile Leu Arg Asp Phe Thr Ile Pro Val Ser
500 505 510
<210> 87
<211> 1372
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1363)
<223> FRXA01762
<400> 87
tggagtgatg aattttccta tagaacgttt tttaaacgat tgacttttta aacgtttacg 60
cttttaatga cttcaaacgt gatctaaagc acaaaggaga atg aaa gtg aac ctc 115
Met Lys Val Asn Leu
1 5
gga ata gga agc tac cca cga cgc agg gca act gtt cga cca gag tcc 163
Gly Ile Gly Ser Tyr Pro Arg Arg Arg Ala Thr Val Arg Pro Glu Ser
10 15 20
act gca atc gaa ttc gaa ggc acc agc atc acc tac gga gaa ttc agc 211
Thr Ala Ile Glu Phe Glu Gly Thr Ser Ile Thr Tyr Gly Glu Phe Ser
25 30 35
aaa cga gtc aat cgg ctt gga cat gct ctt cta gac ctc ggc gtt gcg 259
Lys Arg Val Asn Arg Leu Gly His Ala Leu Leu Asp Leu Gly Val Ala
40 45 50
cac caa gat cga gta gct tat gtc gga ttc aac cac cct gcc ctg cta 307
His Gln Asp Arg Val Ala Tyr Val Gly Phe Asn His Pro Ala Leu Leu
55 60 65
gaa gtg ttc ttt tca acg aac ctc att ggg gca aca ccc gtg ctt gtt 355
Glu Val Phe Phe Ser Thr Asn Leu Ile Gly Ala Thr Pro Val Leu Val
70 75 80 85
aac cct cgc cta tcg gca aac gaa atc gat tac atc atc caa gac agc 403
Asn Pro Arg Leu Ser Ala Asn Glu Ile Asp Tyr Ile Ile Gln Asp Ser
90 95 100
ggt gcg agc atc gtg ttt tac gga atc gac ctc atc gag cac gcc act 451
Gly Ala Ser Ile Val Phe Tyr Gly Ile Asp Leu Ile Glu His Ala Thr
105 110 115
tac ctc caa gaa ctc cat cca gag atc atc atg gtg gcc gtt gaa ggc 499
Tyr Leu Gln Glu Leu His Pro Glu Ile Ile Met Val Ala Val Glu Gly
120 125 130
gat gag ggt cca ggt ttg cgt cga aaa gcg ctt att gaa gcg gcg agc 547
Asp Glu Gly Pro Gly Leu Arg Arg Lys Ala Leu Ile Glu Ala Ala Ser
135 140 145
gac gcc gac atc gac cta gaa gtc agc gat gat gac ctg gtg ctg ctc 595
Asp Ala Asp Ile Asp Leu Glu Val Ser Asp Asp Asp Leu Val Leu Leu
150 155 160 165
atg tac acc tcc gga acc act ggc cgc cca aag ggc gcc atg tta tcc 643
Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Ala Met Leu Ser
170 175 180
cac cga aac ctc ttc ttt aac tac ttc aat gcc ctg ctc agc cag gaa 691
His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Ala Leu Leu Ser Gln Glu
185 190 195
att gaa caa ggc gcg gta ctt tta tcc act gcg ccg tta ttc cac atc 739
Ile Glu Gln Gly Ala Val Leu Leu Ser Thr Ala Pro Leu Phe His Ile
200 205 210
gcg ggc ctc aac atg acc acc atc ccg gtg atg atg aag ggc gga aag 787
Ala Gly Leu Asn Met Thr Thr Ile Pro Val Met Met Lys Gly Gly Lys
215 220 225
gtg atc atc cac cgc gaa ttc cgg gca gag cac gtc ctc gac gaa atc 835
Val Ile Ile His Arg Glu Phe Arg Ala Glu His Val Leu Asp Glu Ile
230 235 240 245
gaa cgc tcc aag gta tcc gaa tcc ttc atg gtg cca gcg atg atc gac 883
Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val Pro Ala Met Ile Asp
250 255 260
atg ttg tcc aac cac cca tca ttt gcc gaa cgc gac ctt tct tcc ctt 931
Met Leu Ser Asn His Pro Ser Phe Ala Glu Arg Asp Leu Ser Ser Leu
265 270 275
cgc gcc atc atg gtg ggc ggc tct ccc ctt agc gaa cgt gcg ctg cga 979
Arg Ala Ile Met Val Gly Gly Ser Pro Leu Ser Glu Arg Ala Leu Arg
280 285 290
atc tgg caa gga cgc gac gta aaa att gtc caa ggc ttc ggc atg aca 1027
Ile Trp Gln Gly Arg Asp Val Lys Ile Val Gln Gly Phe Gly Met Thr
295 300 305
gaa acc gca ccg ggc gcc tgt atc ctc gag gca aca gac aca agc aca 1075
Glu Thr Ala Pro Gly Ala Cys Ile Leu Glu Ala Thr Asp Thr Ser Thr
310 315 320 325
cac ctt gga acc gca ggt cga gcc cac ttc ttc acc gac atc aaa cta 1123
His Leu Gly Thr Ala Gly Arg Ala His Phe Phe Thr Asp Ile Lys Leu
330 335 340
gtg gac ccg aaa acc ggc gaa gaa gtc ccc acc gga gag gcc ggc gaa 1171
Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr Gly Glu Ala Gly Glu
345 350 355
gtt ctc atc cgc gga cca cat gtg atg acc gga tac tgg aac cga cca 1219
Val Leu Ile Arg Gly Pro His Val Met Thr Gly Tyr Trp Asn Arg Pro
360 365 370
gaa gac acc gcc agc gca cta caa aat ggc tgg tac cac tcc gga gat 1267
Glu Asp Thr Ala Ser Ala Leu Gln Asn Gly Trp Tyr His Ser Gly Asp
375 380 385
atc gcc atc aaa gat gaa gac ggc tac tac acc atc aaa gac cgc atc 1315
Ile Ala Ile Lys Asp Glu Asp Gly Tyr Tyr Thr Ile Lys Asp Arg Ile
390 395 400 405
aaa gac atg tac atc tcc ggc ggc gaa aac att tac ccc gca gaa gtc 1363
Lys Asp Met Tyr Ile Ser Gly Gly Glu Asn Ile Tyr Pro Ala Glu Val
410 415 420
taagtaccc 1372
<210> 88
<211> 421
<212> PRT
<213> Corynebacterium glutamicum
<400> 88
Met Lys Val Asn Leu Gly Ile Gly Ser Tyr Pro Arg Arg Arg Ala Thr
1 5 10 15
Val Arg Pro Glu Ser Thr Ala Ile Glu Phe Glu Gly Thr Ser Ile Thr
20 25 30
Tyr Gly Glu Phe Ser Lys Arg Val Asn Arg Leu Gly His Ala Leu Leu
35 40 45
Asp Leu Gly Val Ala His Gln Asp Arg Val Ala Tyr Val Gly Phe Asn
50 55 60
His Pro Ala Leu Leu Glu Val Phe Phe Ser Thr Asn Leu Ile Gly Ala
65 70 75 80
Thr Pro Val Leu Val Asn Pro Arg Leu Ser Ala Asn Glu Ile Asp Tyr
85 90 95
Ile Ile Gln Asp Ser Gly Ala Ser Ile Val Phe Tyr Gly Ile Asp Leu
100 105 110
Ile Glu His Ala Thr Tyr Leu Gln Glu Leu His Pro Glu Ile Ile Met
115 120 125
Val Ala Val Glu Gly Asp Glu Gly Pro Gly Leu Arg Arg Lys Ala Leu
130 135 140
Ile Glu Ala Ala Ser Asp Ala Asp Ile Asp Leu Glu Val Ser Asp Asp
145 150 155 160
Asp Leu Val Leu Leu Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys
165 170 175
Gly Ala Met Leu Ser His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Ala
180 185 190
Leu Leu Ser Gln Glu Ile Glu Gln Gly Ala Val Leu Leu Ser Thr Ala
195 200 205
Pro Leu Phe His Ile Ala Gly Leu Asn Met Thr Thr Ile Pro Val Met
210 215 220
Met Lys Gly Gly Lys Val Ile Ile His Arg Glu Phe Arg Ala Glu His
225 230 235 240
Val Leu Asp Glu Ile Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val
245 250 255
Pro Ala Met Ile Asp Met Leu Ser Asn His Pro Ser Phe Ala Glu Arg
260 265 270
Asp Leu Ser Ser Leu Arg Ala Ile Met Val Gly Gly Ser Pro Leu Ser
275 280 285
Glu Arg Ala Leu Arg Ile Trp Gln Gly Arg Asp Val Lys Ile Val Gln
290 295 300
Gly Phe Gly Met Thr Glu Thr Ala Pro Gly Ala Cys Ile Leu Glu Ala
305 310 315 320
Thr Asp Thr Ser Thr His Leu Gly Thr Ala Gly Arg Ala His Phe Phe
325 330 335
Thr Asp Ile Lys Leu Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr
340 345 350
Gly Glu Ala Gly Glu Val Leu Ile Arg Gly Pro His Val Met Thr Gly
355 360 365
Tyr Trp Asn Arg Pro Glu Asp Thr Ala Ser Ala Leu Gln Asn Gly Trp
370 375 380
Tyr His Ser Gly Asp Ile Ala Ile Lys Asp Glu Asp Gly Tyr Tyr Thr
385 390 395 400
Ile Lys Asp Arg Ile Lys Asp Met Tyr Ile Ser Gly Gly Glu Asn Ile
405 410 415
Tyr Pro Ala Glu Val
420
<210> 89
<211> 867
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(844)
<223> RXA00681
<400> 89
aagggcaagg ttgtcattgt tgatccagat gcgccacgca tcgaaggacc cggcgcgcac 60
agccatgcgc actcagtagc agcacatggg gtggatacac atg cct agt cca cgc 115
Met Pro Ser Pro Arg
1 5
act gtt ctt atc act ggt gcc gct ggc ggt ttg ggt cgg gca ttc gct 163
Thr Val Leu Ile Thr Gly Ala Ala Gly Gly Leu Gly Arg Ala Phe Ala
10 15 20
gaa ggt ttc gca gcc caa gga gac cgt atc gcg gtg gcg gat atc aat 211
Glu Gly Phe Ala Ala Gln Gly Asp Arg Ile Ala Val Ala Asp Ile Asn
25 30 35
ctg gat ggg gcg caa gag acc gtt gac aag ctg aaa gca ttg ggc gca 259
Leu Asp Gly Ala Gln Glu Thr Val Asp Lys Leu Lys Ala Leu Gly Ala
40 45 50
gat gcc gca gcc ttt gaa gtt gat gtc acg tct ttg gag tcc acc gag 307
Asp Ala Ala Ala Phe Glu Val Asp Val Thr Ser Leu Glu Ser Thr Glu
55 60 65
gcc cta gcc gcc ggt gcc gct gag ttt ggc ggt ggc cga att gat gtc 355
Ala Leu Ala Ala Gly Ala Ala Glu Phe Gly Gly Gly Arg Ile Asp Val
70 75 80 85
ctt att aat aac gca gcg ata tat gcg aca gtg act cgt tca ccg ttt 403
Leu Ile Asn Asn Ala Ala Ile Tyr Ala Thr Val Thr Arg Ser Pro Phe
90 95 100
gag gat att gac cct gcg gag tgg gat ttg gtc atg gga gtc aat ctc 451
Glu Asp Ile Asp Pro Ala Glu Trp Asp Leu Val Met Gly Val Asn Leu
105 110 115
aaa ggc ccg tgg ttg gtg acg cgt tct gtg agt ccg ttt ttg tcc gat 499
Lys Gly Pro Trp Leu Val Thr Arg Ser Val Ser Pro Phe Leu Ser Asp
120 125 130
aat gcc cgt gtg gtc aat ctt tcc agc gcg act gtg ttt tca gga tct 547
Asn Ala Arg Val Val Asn Leu Ser Ser Ala Thr Val Phe Ser Gly Ser
135 140 145
gca cac tgg gcg cac tac gtg gca tcc aaa ggt ggg gtc att gct tta 595
Ala His Trp Ala His Tyr Val Ala Ser Lys Gly Gly Val Ile Ala Leu
150 155 160 165
acc agg gtg ctt gct aaa gag ctg ggt ggt cgt ggg atc acg gtc aat 643
Thr Arg Val Leu Ala Lys Glu Leu Gly Gly Arg Gly Ile Thr Val Asn
170 175 180
gcg gtt gcg cct ggg ttt acg ctg act gaa gcc agc ttg gga ctc atg 691
Ala Val Ala Pro Gly Phe Thr Leu Thr Glu Ala Ser Leu Gly Leu Met
185 190 195
gat agc gcg gaa acg tac ggt gtc gat cgc gga tcc atc aag cgc gca 739
Asp Ser Ala Glu Thr Tyr Gly Val Asp Arg Gly Ser Ile Lys Arg Ala
200 205 210
agc caa ccg aaa gac atc gtc ggc acc acc atg ttt ctt gca tcc cca 787
Ser Gln Pro Lys Asp Ile Val Gly Thr Thr Met Phe Leu Ala Ser Pro
215 220 225
gaa gcc gaa tac atc act ggg caa aca ctc atc gtt gat ggt ggc cga 835
Glu Ala Glu Tyr Ile Thr Gly Gln Thr Leu Ile Val Asp Gly Gly Arg
230 235 240 245
cag ttc atc taagtactaa aagttctaag gag 867
Gln Phe Ile
<210> 90
<211> 248
<212> PRT
<213> Corynebacterium glutamicum
<400> 90
Met Pro Ser Pro Arg Thr Val Leu Ile Thr Gly Ala Ala Gly Gly Leu
1 5 10 15
Gly Arg Ala Phe Ala Glu Gly Phe Ala Ala Gln Gly Asp Arg Ile Ala
20 25 30
Val Ala Asp Ile Asn Leu Asp Gly Ala Gln Glu Thr Val Asp Lys Leu
35 40 45
Lys Ala Leu Gly Ala Asp Ala Ala Ala Phe Glu Val Asp Val Thr Ser
50 55 60
Leu Glu Ser Thr Glu Ala Leu Ala Ala Gly Ala Ala Glu Phe Gly Gly
65 70 75 80
Gly Arg Ile Asp Val Leu Ile Asn Asn Ala Ala Ile Tyr Ala Thr Val
85 90 95
Thr Arg Ser Pro Phe Glu Asp Ile Asp Pro Ala Glu Trp Asp Leu Val
100 105 110
Met Gly Val Asn Leu Lys Gly Pro Trp Leu Val Thr Arg Ser Val Ser
115 120 125
Pro Phe Leu Ser Asp Asn Ala Arg Val Val Asn Leu Ser Ser Ala Thr
130 135 140
Val Phe Ser Gly Ser Ala His Trp Ala His Tyr Val Ala Ser Lys Gly
145 150 155 160
Gly Val Ile Ala Leu Thr Arg Val Leu Ala Lys Glu Leu Gly Gly Arg
165 170 175
Gly Ile Thr Val Asn Ala Val Ala Pro Gly Phe Thr Leu Thr Glu Ala
180 185 190
Ser Leu Gly Leu Met Asp Ser Ala Glu Thr Tyr Gly Val Asp Arg Gly
195 200 205
Ser Ile Lys Arg Ala Ser Gln Pro Lys Asp Ile Val Gly Thr Thr Met
210 215 220
Phe Leu Ala Ser Pro Glu Ala Glu Tyr Ile Thr Gly Gln Thr Leu Ile
225 230 235 240
Val Asp Gly Gly Arg Gln Phe Ile
245
<210> 91
<211> 837
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(814)
<223> RXA00802
<400> 91
gccatggtga tcacaccagt gtgggggctg aggctccaca cttggaggaa tggattaaac 60
gcgggcacta agccccgaac gattagtagg cttgggcacc atg gat ctt aaa ctt 115
Met Asp Leu Lys Leu
1 5
ggt ggc caa gtc ata ctt gtt gtt ggc ggt gca gga act att ggt tct 163
Gly Gly Gln Val Ile Leu Val Val Gly Gly Ala Gly Thr Ile Gly Ser
10 15 20
gaa gtt gta aaa ctc tta act gaa gaa ggc gca acc gcg gta gcg gcg 211
Glu Val Val Lys Leu Leu Thr Glu Glu Gly Ala Thr Ala Val Ala Ala
25 30 35
tcg aga agc acg ccc tta tct att gac gct tcg gat gaa gcg tcc gtc 259
Ser Arg Ser Thr Pro Leu Ser Ile Asp Ala Ser Asp Glu Ala Ser Val
40 45 50
cgt gcg ggc att gat cag gtg atc gca gaa cat ggt cgc ctg gat ggg 307
Arg Ala Gly Ile Asp Gln Val Ile Ala Glu His Gly Arg Leu Asp Gly
55 60 65
ctg gtt gtt tct tct gca ccc gct gcg caa acg ctc agc gcg gag aca 355
Leu Val Val Ser Ser Ala Pro Ala Ala Gln Thr Leu Ser Ala Glu Thr
70 75 80 85
gca gat gat ccg gac act gtg ttg gct gct att gaa ggc aaa gcc atc 403
Ala Asp Asp Pro Asp Thr Val Leu Ala Ala Ile Glu Gly Lys Ala Ile
90 95 100
acg ttt atg aag gct gca acc gtg gcg ctc gag aag atg cgt gag gct 451
Thr Phe Met Lys Ala Ala Thr Val Ala Leu Glu Lys Met Arg Glu Ala
105 110 115
gga cat ggg cgc atc gtt gca ctt tcc ggc atg aac tca tac aaa aca 499
Gly His Gly Arg Ile Val Ala Leu Ser Gly Met Asn Ser Tyr Lys Thr
120 125 130
ttg agt act act gcg tcg gcg cga aat gct gcg ctg aat gtc gtg gtg 547
Leu Ser Thr Thr Ala Ser Ala Arg Asn Ala Ala Leu Asn Val Val Val
135 140 145
aaa aat ttg gcg gat cgt cac gcg ggc acc gga att aca gta aat gcg 595
Lys Asn Leu Ala Asp Arg His Ala Gly Thr Gly Ile Thr Val Asn Ala
150 155 160 165
att agc ccg gga ttc gtg gta gct gag cca gac gct gag gta aac cgc 643
Ile Ser Pro Gly Phe Val Val Ala Glu Pro Asp Ala Glu Val Asn Arg
170 175 180
gca aat ggt gac acc acg tgg agg agg tcg cgg agg cga tcg cgt ttt 691
Ala Asn Gly Asp Thr Thr Trp Arg Arg Ser Arg Arg Arg Ser Arg Phe
185 190 195
tgt tgt cgc cgc gca ccg cat caa ttt ctg gag aga tta ttt cgg tgg 739
Cys Cys Arg Arg Ala Pro His Gln Phe Leu Glu Arg Leu Phe Arg Trp
200 205 210
gac ata agg cga agg gca tca tcc ttc ctt agc tcg cgt gag ctt ccc 787
Asp Ile Arg Arg Arg Ala Ser Ser Phe Leu Ser Ser Arg Glu Leu Pro
215 220 225
aag cgt aag cac ccc cgt gtg agg gca taacggccgt tctgttaaag 834
Lys Arg Lys His Pro Arg Val Arg Ala
230 235
att 837
<210> 92
<211> 238
<212> PRT
<213> Corynebacterium glutamicum
<400> 92
Met Asp Leu Lys Leu Gly Gly Gln Val Ile Leu Val Val Gly Gly Ala
1 5 10 15
Gly Thr Ile Gly Ser Glu Val Val Lys Leu Leu Thr Glu Glu Gly Ala
20 25 30
Thr Ala Val Ala Ala Ser Arg Ser Thr Pro Leu Ser Ile Asp Ala Ser
35 40 45
Asp Glu Ala Ser Val Arg Ala Gly Ile Asp Gln Val Ile Ala Glu His
50 55 60
Gly Arg Leu Asp Gly Leu Val Val Ser Ser Ala Pro Ala Ala Gln Thr
65 70 75 80
Leu Ser Ala Glu Thr Ala Asp Asp Pro Asp Thr Val Leu Ala Ala Ile
85 90 95
Glu Gly Lys Ala Ile Thr Phe Met Lys Ala Ala Thr Val Ala Leu Glu
100 105 110
Lys Met Arg Glu Ala Gly His Gly Arg Ile Val Ala Leu Ser Gly Met
115 120 125
Asn Ser Tyr Lys Thr Leu Ser Thr Thr Ala Ser Ala Arg Asn Ala Ala
130 135 140
Leu Asn Val Val Val Lys Asn Leu Ala Asp Arg His Ala Gly Thr Gly
145 150 155 160
Ile Thr Val Asn Ala Ile Ser Pro Gly Phe Val Val Ala Glu Pro Asp
165 170 175
Ala Glu Val Asn Arg Ala Asn Gly Asp Thr Thr Trp Arg Arg Ser Arg
180 185 190
Arg Arg Ser Arg Phe Cys Cys Arg Arg Ala Pro His Gln Phe Leu Glu
195 200 205
Arg Leu Phe Arg Trp Asp Ile Arg Arg Arg Ala Ser Ser Phe Leu Ser
210 215 220
Ser Arg Glu Leu Pro Lys Arg Lys His Pro Arg Val Arg Ala
225 230 235
<210> 93
<211> 329
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(306)
<223> RXA02133
<400> 93
gaa aac ccc tac att ggc gga gct gga tac aac gca gca aaa ttc ggt 48
Glu Asn Pro Tyr Ile Gly Gly Ala Gly Tyr Asn Ala Ala Lys Phe Gly
1 5 10 15
gta gca gca ttc aac cgt gtg ctt cgc ttg gaa acc cac cag cag acc 96
Val Ala Ala Phe Asn Arg Val Leu Arg Leu Glu Thr His Gln Gln Thr
20 25 30
ctt cgc gta tct gag atc gat cca ggt cga gtt gcc acg gaa gaa ttc 144
Leu Arg Val Ser Glu Ile Asp Pro Gly Arg Val Ala Thr Glu Glu Phe
35 40 45
tcc ctc gtt cgt ttc ggc gga gat aaa gaa cgc gca gaa gca gtc tat 192
Ser Leu Val Arg Phe Gly Gly Asp Lys Glu Arg Ala Glu Ala Val Tyr
50 55 60
gac gac gtc ctc aac ctc acc gct gaa gac atc gca gag tct gtg cgt 240
Asp Asp Val Leu Asn Leu Thr Ala Glu Asp Ile Ala Glu Ser Val Arg
65 70 75 80
tgg gtc gcg agc ctt cca aag cac atg aac att gac cgc atg cgt att 288
Trp Val Ala Ser Leu Pro Lys His Met Asn Ile Asp Arg Met Arg Ile
85 90 95
aca cct cgc gat cag gtc taaaacccgc actcttttga aat 329
Thr Pro Arg Asp Gln Val
100
<210> 94
<211> 102
<212> PRT
<213> Corynebacterium glutamicum
<400> 94
Glu Asn Pro Tyr Ile Gly Gly Ala Gly Tyr Asn Ala Ala Lys Phe Gly
1 5 10 15
Val Ala Ala Phe Asn Arg Val Leu Arg Leu Glu Thr His Gln Gln Thr
20 25 30
Leu Arg Val Ser Glu Ile Asp Pro Gly Arg Val Ala Thr Glu Glu Phe
35 40 45
Ser Leu Val Arg Phe Gly Gly Asp Lys Glu Arg Ala Glu Ala Val Tyr
50 55 60
Asp Asp Val Leu Asn Leu Thr Ala Glu Asp Ile Ala Glu Ser Val Arg
65 70 75 80
Trp Val Ala Ser Leu Pro Lys His Met Asn Ile Asp Arg Met Arg Ile
85 90 95
Thr Pro Arg Asp Gln Val
100
<210> 95
<211> 1347
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1324)
<223> RXN01114
<400> 95
ttcggtggaa gatatccgca agctggtgct gccgcagctt ttagaaacgg ctcaagcaat 60
ttcgacagat ctctctgcac tctaaattaa ggatcaaaaa atg aac cct caa gat 115
Met Asn Pro Gln Asp
1 5
att gtc atc tgt tcc cca ttg cgc acc cca gtt ggt gct tac ggc gga 163
Ile Val Ile Cys Ser Pro Leu Arg Thr Pro Val Gly Ala Tyr Gly Gly
10 15 20
tcc ttc acc ggc gtc cct gtt gaa gaa ttg gcc acc acc gtg atc aac 211
Ser Phe Thr Gly Val Pro Val Glu Glu Leu Ala Thr Thr Val Ile Asn
25 30 35
gcg atc gtt gag gca acc ggc atc acc ggc gac gat gtg gac gat ctg 259
Ala Ile Val Glu Ala Thr Gly Ile Thr Gly Asp Asp Val Asp Asp Leu
40 45 50
atc ctc ggc cag gca tcc ccc aac ggt gcg gct cca gca ctg ggc cgt 307
Ile Leu Gly Gln Ala Ser Pro Asn Gly Ala Ala Pro Ala Leu Gly Arg
55 60 65
gtt gtt gct cta gat tcc aag ctt ggc caa aac gtt cca ggc atg cag 355
Val Val Ala Leu Asp Ser Lys Leu Gly Gln Asn Val Pro Gly Met Gln
70 75 80 85
ctt gat cgc cgc tgt ggt tcc ggc ctg cag gca atc gtc acc gct gct 403
Leu Asp Arg Arg Cys Gly Ser Gly Leu Gln Ala Ile Val Thr Ala Ala
90 95 100
gca cac gtt gca tcc ggc gct gct gat ctg atc atc gca ggt ggc gca 451
Ala His Val Ala Ser Gly Ala Ala Asp Leu Ile Ile Ala Gly Gly Ala
105 110 115
gaa tcc atg agc cgc gtt gag tac acc gtg tcc ggc gat atc cgt tgg 499
Glu Ser Met Ser Arg Val Glu Tyr Thr Val Ser Gly Asp Ile Arg Trp
120 125 130
ggt gtc aag ggc ggc gac atg cag ctt cgt gac cgc ctt gca gaa gca 547
Gly Val Lys Gly Gly Asp Met Gln Leu Arg Asp Arg Leu Ala Glu Ala
135 140 145
cgc gaa acc gct ggc gga cgc aac cac ccg atc cct ggt ggc atg atc 595
Arg Glu Thr Ala Gly Gly Arg Asn His Pro Ile Pro Gly Gly Met Ile
150 155 160 165
gag acc gct gag aac ctg cgt cgc gaa tac ggc atc tcc cgc gag gag 643
Glu Thr Ala Glu Asn Leu Arg Arg Glu Tyr Gly Ile Ser Arg Glu Glu
170 175 180
cag gac aag atc tcc gca gcg tcc cag cag cgt tgg ggc aag gct gct 691
Gln Asp Lys Ile Ser Ala Ala Ser Gln Gln Arg Trp Gly Lys Ala Ala
185 190 195
gat gcg ggg ctt ttc gac gac gag atc gtg cca gtc acc gtc cct gcc 739
Asp Ala Gly Leu Phe Asp Asp Glu Ile Val Pro Val Thr Val Pro Ala
200 205 210
aag aag cgc ggc cag gag cca acc atc gtt tct cga gac gag cat ggt 787
Lys Lys Arg Gly Gln Glu Pro Thr Ile Val Ser Arg Asp Glu His Gly
215 220 225
cga cca gga aca acc gtc gaa aag ctt gct gct ttg cgc ccc atc atg 835
Arg Pro Gly Thr Thr Val Glu Lys Leu Ala Ala Leu Arg Pro Ile Met
230 235 240 245
ggc cgc cag gat gcg gaa gca acc gtc acc gct ggc aac gcg tcc ggc 883
Gly Arg Gln Asp Ala Glu Ala Thr Val Thr Ala Gly Asn Ala Ser Gly
250 255 260
caa aat gat ggc gct gct gcc gtc atc gtg acc act cgc gcc aag gcc 931
Gln Asn Asp Gly Ala Ala Ala Val Ile Val Thr Thr Arg Ala Lys Ala
265 270 275
gag gag aag ggc ctg cgc cca gtc atg cgt ttg gct ggc tgg tct gtg 979
Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu Ala Gly Trp Ser Val
280 285 290
gct gct gtt ccc cca gag acc atg ggt att gga cct gtt cct gcc acc 1027
Ala Ala Val Pro Pro Glu Thr Met Gly Ile Gly Pro Val Pro Ala Thr
295 300 305
aag aag gtc ctg gat cgt ttg ggc ctt acc ctg gag gac atc ggc gcg 1075
Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu Glu Asp Ile Gly Ala
310 315 320 325
atc gaa ctc aac gaa gct ttc gca gct cag gca ctg tct gtg ctg aag 1123
Ile Glu Leu Asn Glu Ala Phe Ala Ala Gln Ala Leu Ser Val Leu Lys
330 335 340
gaa tgg aac att tct tgg gaa gat gag cgc gtc aac cca ctg ggt tcc 1171
Glu Trp Asn Ile Ser Trp Glu Asp Glu Arg Val Asn Pro Leu Gly Ser
345 350 355
ggt att tcc atg gga cac cca gtc ggt gcc acc ggt gct cgc atg gca 1219
Gly Ile Ser Met Gly His Pro Val Gly Ala Thr Gly Ala Arg Met Ala
360 365 370
gta acc ttg gct cac cgc atg cag cgt gaa aac act cag tac gga ctg 1267
Val Thr Leu Ala His Arg Met Gln Arg Glu Asn Thr Gln Tyr Gly Leu
375 380 385
gcc acc atg tgc atc ggt ggc ggc cag ggt ctt gca gct gtc ttt gaa 1315
Ala Thr Met Cys Ile Gly Gly Gly Gln Gly Leu Ala Ala Val Phe Glu
390 395 400 405
aag gag aac taaaaatggc tattttgcac agc 1347
Lys Glu Asn
<210> 96
<211> 408
<212> PRT
<213> Corynebacterium glutamicum
<400> 96
Met Asn Pro Gln Asp Ile Val Ile Cys Ser Pro Leu Arg Thr Pro Val
1 5 10 15
Gly Ala Tyr Gly Gly Ser Phe Thr Gly Val Pro Val Glu Glu Leu Ala
20 25 30
Thr Thr Val Ile Asn Ala Ile Val Glu Ala Thr Gly Ile Thr Gly Asp
35 40 45
Asp Val Asp Asp Leu Ile Leu Gly Gln Ala Ser Pro Asn Gly Ala Ala
50 55 60
Pro Ala Leu Gly Arg Val Val Ala Leu Asp Ser Lys Leu Gly Gln Asn
65 70 75 80
Val Pro Gly Met Gln Leu Asp Arg Arg Cys Gly Ser Gly Leu Gln Ala
85 90 95
Ile Val Thr Ala Ala Ala His Val Ala Ser Gly Ala Ala Asp Leu Ile
100 105 110
Ile Ala Gly Gly Ala Glu Ser Met Ser Arg Val Glu Tyr Thr Val Ser
115 120 125
Gly Asp Ile Arg Trp Gly Val Lys Gly Gly Asp Met Gln Leu Arg Asp
130 135 140
Arg Leu Ala Glu Ala Arg Glu Thr Ala Gly Gly Arg Asn His Pro Ile
145 150 155 160
Pro Gly Gly Met Ile Glu Thr Ala Glu Asn Leu Arg Arg Glu Tyr Gly
165 170 175
Ile Ser Arg Glu Glu Gln Asp Lys Ile Ser Ala Ala Ser Gln Gln Arg
180 185 190
Trp Gly Lys Ala Ala Asp Ala Gly Leu Phe Asp Asp Glu Ile Val Pro
195 200 205
Val Thr Val Pro Ala Lys Lys Arg Gly Gln Glu Pro Thr Ile Val Ser
210 215 220
Arg Asp Glu His Gly Arg Pro Gly Thr Thr Val Glu Lys Leu Ala Ala
225 230 235 240
Leu Arg Pro Ile Met Gly Arg Gln Asp Ala Glu Ala Thr Val Thr Ala
245 250 255
Gly Asn Ala Ser Gly Gln Asn Asp Gly Ala Ala Ala Val Ile Val Thr
260 265 270
Thr Arg Ala Lys Ala Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu
275 280 285
Ala Gly Trp Ser Val Ala Ala Val Pro Pro Glu Thr Met Gly Ile Gly
290 295 300
Pro Val Pro Ala Thr Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu
305 310 315 320
Glu Asp Ile Gly Ala Ile Glu Leu Asn Glu Ala Phe Ala Ala Gln Ala
325 330 335
Leu Ser Val Leu Lys Glu Trp Asn Ile Ser Trp Glu Asp Glu Arg Val
340 345 350
Asn Pro Leu Gly Ser Gly Ile Ser Met Gly His Pro Val Gly Ala Thr
355 360 365
Gly Ala Arg Met Ala Val Thr Leu Ala His Arg Met Gln Arg Glu Asn
370 375 380
Thr Gln Tyr Gly Leu Ala Thr Met Cys Ile Gly Gly Gly Gln Gly Leu
385 390 395 400
Ala Ala Val Phe Glu Lys Glu Asn
405
<210> 97
<211> 815
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(792)
<223> FRXA01114
<400> 97
cgc ctt gca gaa gca cgc gaa acc gct ggc gga cgc aac cac ccg atc 48
Arg Leu Ala Glu Ala Arg Glu Thr Ala Gly Gly Arg Asn His Pro Ile
1 5 10 15
cct ggt ggc atg atc gag acc gct gag aac ctg cgt cgc gaa tac ggc 96
Pro Gly Gly Met Ile Glu Thr Ala Glu Asn Leu Arg Arg Glu Tyr Gly
20 25 30
atc tcc cgc gag gag cag gac aag atc tcc gca gcg tcc cag cag cgt 144
Ile Ser Arg Glu Glu Gln Asp Lys Ile Ser Ala Ala Ser Gln Gln Arg
35 40 45
tgg ggc aag gct gct gat gcg ggg ctt ttc gac gac gag atc gtg cca 192
Trp Gly Lys Ala Ala Asp Ala Gly Leu Phe Asp Asp Glu Ile Val Pro
50 55 60
gtc acc gtc cct gcc aag aag cgc ggc cag gag cca acc atc gtt tct 240
Val Thr Val Pro Ala Lys Lys Arg Gly Gln Glu Pro Thr Ile Val Ser
65 70 75 80
cga gac gag cat ggt cga cca gga aca acc gtc gaa aag ctt gct gct 288
Arg Asp Glu His Gly Arg Pro Gly Thr Thr Val Glu Lys Leu Ala Ala
85 90 95
ttg cgc ccc atc atg ggc cgc cag gat gcg gaa gca acc gtc acc gct 336
Leu Arg Pro Ile Met Gly Arg Gln Asp Ala Glu Ala Thr Val Thr Ala
100 105 110
ggc aac gcg tcc ggc caa aat gat ggc gct gct gcc gtc atc gtg acc 384
Gly Asn Ala Ser Gly Gln Asn Asp Gly Ala Ala Ala Val Ile Val Thr
115 120 125
act cgc gcc aag gcc gag gag aag ggc ctg cgc cca gtc atg cgt ttg 432
Thr Arg Ala Lys Ala Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu
130 135 140
gct ggc tgg tct gtg gct gct gtt ccc cca gag acc atg ggt att gga 480
Ala Gly Trp Ser Val Ala Ala Val Pro Pro Glu Thr Met Gly Ile Gly
145 150 155 160
cct gtt cct gcc acc aag aag gtc ctg gat cgt ttg ggc ctt acc ctg 528
Pro Val Pro Ala Thr Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu
165 170 175
gag gac atc ggc gcg atc gaa ctc aac gaa gct ttc gca gct cag gca 576
Glu Asp Ile Gly Ala Ile Glu Leu Asn Glu Ala Phe Ala Ala Gln Ala
180 185 190
ctg tct gtg ctg aag gaa tgg aac att tct tgg gaa gat gag cgc gtc 624
Leu Ser Val Leu Lys Glu Trp Asn Ile Ser Trp Glu Asp Glu Arg Val
195 200 205
aac cca ctg ggt tcc ggt att tcc atg gga cac cca gtc ggt gcc acc 672
Asn Pro Leu Gly Ser Gly Ile Ser Met Gly His Pro Val Gly Ala Thr
210 215 220
ggt gct cgc atg gca gta acc ttg gct cac cgc atg cag cgt gaa aac 720
Gly Ala Arg Met Ala Val Thr Leu Ala His Arg Met Gln Arg Glu Asn
225 230 235 240
act cag tac gga ctg gcc acc atg tgc atc ggt ggc ggc cag ggt ctt 768
Thr Gln Tyr Gly Leu Ala Thr Met Cys Ile Gly Gly Gly Gln Gly Leu
245 250 255
gca gct gtc ttt gaa aag gag aac taaaaatggc tattttgcac agc 815
Ala Ala Val Phe Glu Lys Glu Asn
260
<210> 98
<211> 264
<212> PRT
<213> Corynebacterium glutamicum
<400> 98
Arg Leu Ala Glu Ala Arg Glu Thr Ala Gly Gly Arg Asn His Pro Ile
1 5 10 15
Pro Gly Gly Met Ile Glu Thr Ala Glu Asn Leu Arg Arg Glu Tyr Gly
20 25 30
Ile Ser Arg Glu Glu Gln Asp Lys Ile Ser Ala Ala Ser Gln Gln Arg
35 40 45
Trp Gly Lys Ala Ala Asp Ala Gly Leu Phe Asp Asp Glu Ile Val Pro
50 55 60
Val Thr Val Pro Ala Lys Lys Arg Gly Gln Glu Pro Thr Ile Val Ser
65 70 75 80
Arg Asp Glu His Gly Arg Pro Gly Thr Thr Val Glu Lys Leu Ala Ala
85 90 95
Leu Arg Pro Ile Met Gly Arg Gln Asp Ala Glu Ala Thr Val Thr Ala
100 105 110
Gly Asn Ala Ser Gly Gln Asn Asp Gly Ala Ala Ala Val Ile Val Thr
115 120 125
Thr Arg Ala Lys Ala Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu
130 135 140
Ala Gly Trp Ser Val Ala Ala Val Pro Pro Glu Thr Met Gly Ile Gly
145 150 155 160
Pro Val Pro Ala Thr Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu
165 170 175
Glu Asp Ile Gly Ala Ile Glu Leu Asn Glu Ala Phe Ala Ala Gln Ala
180 185 190
Leu Ser Val Leu Lys Glu Trp Asn Ile Ser Trp Glu Asp Glu Arg Val
195 200 205
Asn Pro Leu Gly Ser Gly Ile Ser Met Gly His Pro Val Gly Ala Thr
210 215 220
Gly Ala Arg Met Ala Val Thr Leu Ala His Arg Met Gln Arg Glu Asn
225 230 235 240
Thr Gln Tyr Gly Leu Ala Thr Met Cys Ile Gly Gly Gly Gln Gly Leu
245 250 255
Ala Ala Val Phe Glu Lys Glu Asn
260
<210> 99
<211> 978
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(955)
<223> RXA01894
<400> 99
agaatttttt cgaaaatgct ggcaccatca acagtgacat tgttagaaac ttcaaggaga 60
acccatgaat gaaccggagc aacatcaccg gtccatgagg atg ccc aaa ccc aaa 115
Met Pro Lys Pro Lys
1 5
aat aat gcg ggt cga gat ctc aaa gct gcc att gct gtg ggg atc gga 163
Asn Asn Ala Gly Arg Asp Leu Lys Ala Ala Ile Ala Val Gly Ile Gly
10 15 20
ctg ggg gtc ctg gtt ctt ttg ggg att gtc cta agc cca tgg ggt tgg 211
Leu Gly Val Leu Val Leu Leu Gly Ile Val Leu Ser Pro Trp Gly Trp
25 30 35
tac atc ctc gtt gca ggt ttt atg gct gca gca aca tgg gaa gtt ggt 259
Tyr Ile Leu Val Ala Gly Phe Met Ala Ala Ala Thr Trp Glu Val Gly
40 45 50
agc aga ctt aaa gaa ggc ggc tat cat ttg cca ctg ccg att atg atc 307
Ser Arg Leu Lys Glu Gly Gly Tyr His Leu Pro Leu Pro Ile Met Ile
55 60 65
atc ggc ggt cag gca atc atc tgg ctg tca tgg cca ttt ggc acg atg 355
Ile Gly Gly Gln Ala Ile Ile Trp Leu Ser Trp Pro Phe Gly Thr Met
70 75 80 85
ggc att ttg gcg tct ttt gtg gcc act gtg ttg gtg ctg atg tat ttc 403
Gly Ile Leu Ala Ser Phe Val Ala Thr Val Leu Val Leu Met Tyr Phe
90 95 100
cga att ttc tac aat ggc acg gaa aaa gaa gcc cgc aac tat ttg agg 451
Arg Ile Phe Tyr Asn Gly Thr Glu Lys Glu Ala Arg Asn Tyr Leu Arg
105 110 115
gac acc tct gtg ggc atc ttc gtg ctc acc tgg att cca ttg ttc gga 499
Asp Thr Ser Val Gly Ile Phe Val Leu Thr Trp Ile Pro Leu Phe Gly
120 125 130
agc ttc gct gcg atg ctg tcg ctg atg caa aac aat tcc atc ccg ggt 547
Ser Phe Ala Ala Met Leu Ser Leu Met Gln Asn Asn Ser Ile Pro Gly
135 140 145
aca tat ttc att ttg acg ttc atg ctg tgt gtg atc gca tcg gat gtg 595
Thr Tyr Phe Ile Leu Thr Phe Met Leu Cys Val Ile Ala Ser Asp Val
150 155 160 165
ggc ggg tat atc gcg ggt gtg ttc ttt gga tcg cac cca atg gcg ccg 643
Gly Gly Tyr Ile Ala Gly Val Phe Phe Gly Ser His Pro Met Ala Pro
170 175 180
ttg gtg agt ccg aag aag tct tgg gaa ggc ttt gcc ggc tcc att gtc 691
Leu Val Ser Pro Lys Lys Ser Trp Glu Gly Phe Ala Gly Ser Ile Val
185 190 195
tta gga tcg gtc act ggt gca ctc agt gtt cac ttc ctg ctc gat cac 739
Leu Gly Ser Val Thr Gly Ala Leu Ser Val His Phe Leu Leu Asp His
200 205 210
cac tgg tgg atg ggt gtg atc ttg ggt tgt gcc cta gtt gtg tgc gcc 787
His Trp Trp Met Gly Val Ile Leu Gly Cys Ala Leu Val Val Cys Ala
215 220 225
acg ttg ggt gac ttg gtt gag tcg cag ttc aaa cgc gat ttg ggc atc 835
Thr Leu Gly Asp Leu Val Glu Ser Gln Phe Lys Arg Asp Leu Gly Ile
230 235 240 245
aag gat atg tcg aac ctt ctt cca ggc cac ggc gga ttg atg gac cgt 883
Lys Asp Met Ser Asn Leu Leu Pro Gly His Gly Gly Leu Met Asp Arg
250 255 260
ttg gat ggc atg ctc ccg gcc gcg atg gtg acg tgg ttg atc ctg agt 931
Leu Asp Gly Met Leu Pro Ala Ala Met Val Thr Trp Leu Ile Leu Ser
265 270 275
gtg atc agc agc tcg tat ccg tcg taaagcttgg gccagcttta agt 978
Val Ile Ser Ser Ser Tyr Pro Ser
280 285
<210> 100
<211> 285
<212> PRT
<213> Corynebacterium glutamicum
<400> 100
Met Pro Lys Pro Lys Asn Asn Ala Gly Arg Asp Leu Lys Ala Ala Ile
1 5 10 15
Ala Val Gly Ile Gly Leu Gly Val Leu Val Leu Leu Gly Ile Val Leu
20 25 30
Ser Pro Trp Gly Trp Tyr Ile Leu Val Ala Gly Phe Met Ala Ala Ala
35 40 45
Thr Trp Glu Val Gly Ser Arg Leu Lys Glu Gly Gly Tyr His Leu Pro
50 55 60
Leu Pro Ile Met Ile Ile Gly Gly Gln Ala Ile Ile Trp Leu Ser Trp
65 70 75 80
Pro Phe Gly Thr Met Gly Ile Leu Ala Ser Phe Val Ala Thr Val Leu
85 90 95
Val Leu Met Tyr Phe Arg Ile Phe Tyr Asn Gly Thr Glu Lys Glu Ala
100 105 110
Arg Asn Tyr Leu Arg Asp Thr Ser Val Gly Ile Phe Val Leu Thr Trp
115 120 125
Ile Pro Leu Phe Gly Ser Phe Ala Ala Met Leu Ser Leu Met Gln Asn
130 135 140
Asn Ser Ile Pro Gly Thr Tyr Phe Ile Leu Thr Phe Met Leu Cys Val
145 150 155 160
Ile Ala Ser Asp Val Gly Gly Tyr Ile Ala Gly Val Phe Phe Gly Ser
165 170 175
His Pro Met Ala Pro Leu Val Ser Pro Lys Lys Ser Trp Glu Gly Phe
180 185 190
Ala Gly Ser Ile Val Leu Gly Ser Val Thr Gly Ala Leu Ser Val His
195 200 205
Phe Leu Leu Asp His His Trp Trp Met Gly Val Ile Leu Gly Cys Ala
210 215 220
Leu Val Val Cys Ala Thr Leu Gly Asp Leu Val Glu Ser Gln Phe Lys
225 230 235 240
Arg Asp Leu Gly Ile Lys Asp Met Ser Asn Leu Leu Pro Gly His Gly
245 250 255
Gly Leu Met Asp Arg Leu Asp Gly Met Leu Pro Ala Ala Met Val Thr
260 265 270
Trp Leu Ile Leu Ser Val Ile Ser Ser Ser Tyr Pro Ser
275 280 285
<210> 101
<211> 600
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(577)
<223> RXA02599
<400> 101
gatcaagcat catacgatgt cggagattgt ggcgggcgtt gttacaggag cagttgcaac 60
cggcatttgt tatgcactcc tacttgcgta aaggagaatt atg gat cag cta atc 115
Met Asp Gln Leu Ile
1 5
ctc gac gca ttt atc ggc ttg aga gtg act tgg ctg agt ccg gtg att 163
Leu Asp Ala Phe Ile Gly Leu Arg Val Thr Trp Leu Ser Pro Val Ile
10 15 20
att ttg ttc acc cag ctc acc ggg cca aca ctg atg ttt gtg tat gcg 211
Ile Leu Phe Thr Gln Leu Thr Gly Pro Thr Leu Met Phe Val Tyr Ala
25 30 35
ctt gtg tgg ggc ttg ttg cgc aag agc gcc act gcc ccg atc gcg gtg 259
Leu Val Trp Gly Leu Leu Arg Lys Ser Ala Thr Ala Pro Ile Ala Val
40 45 50
ggg ctg gct aat ctg atc agt cat ttt ctc aag agg gcg ttt gaa cgg 307
Gly Leu Ala Asn Leu Ile Ser His Phe Leu Lys Arg Ala Phe Glu Arg
55 60 65
cct cga cca aat aca gca gag cac ttg gtt gta gaa act aac ttt tca 355
Pro Arg Pro Asn Thr Ala Glu His Leu Val Val Glu Thr Asn Phe Ser
70 75 80 85
ttc cct tct ggt cat gct gtg ggc gct gca gca tgt gcc gtg gca gtg 403
Phe Pro Ser Gly His Ala Val Gly Ala Ala Ala Cys Ala Val Ala Val
90 95 100
ggg tac tcc gtg aac cgg tgg tgg aaa ctc acg ctg tgg gta atc gcg 451
Gly Tyr Ser Val Asn Arg Trp Trp Lys Leu Thr Leu Trp Val Ile Ala
105 110 115
ctg ctt gtg ggg ctg tct cgg ttg tat gtc ggt gtg cat tgg ccc agc 499
Leu Leu Val Gly Leu Ser Arg Leu Tyr Val Gly Val His Trp Pro Ser
120 125 130
gat gtg ctt gcc ggc tgg gcc atc ggt gcg ttg act tca gtg gtg gtg 547
Asp Val Leu Ala Gly Trp Ala Ile Gly Ala Leu Thr Ser Val Val Val
135 140 145
ttt acc agc tgg aac ctc ctc cag cgc cgc tgaaaccact gctgaaagtg 597
Phe Thr Ser Trp Asn Leu Leu Gln Arg Arg
150 155
gta 600
<210> 102
<211> 159
<212> PRT
<213> Corynebacterium glutamicum
<400> 102
Met Asp Gln Leu Ile Leu Asp Ala Phe Ile Gly Leu Arg Val Thr Trp
1 5 10 15
Leu Ser Pro Val Ile Ile Leu Phe Thr Gln Leu Thr Gly Pro Thr Leu
20 25 30
Met Phe Val Tyr Ala Leu Val Trp Gly Leu Leu Arg Lys Ser Ala Thr
35 40 45
Ala Pro Ile Ala Val Gly Leu Ala Asn Leu Ile Ser His Phe Leu Lys
50 55 60
Arg Ala Phe Glu Arg Pro Arg Pro Asn Thr Ala Glu His Leu Val Val
65 70 75 80
Glu Thr Asn Phe Ser Phe Pro Ser Gly His Ala Val Gly Ala Ala Ala
85 90 95
Cys Ala Val Ala Val Gly Tyr Ser Val Asn Arg Trp Trp Lys Leu Thr
100 105 110
Leu Trp Val Ile Ala Leu Leu Val Gly Leu Ser Arg Leu Tyr Val Gly
115 120 125
Val His Trp Pro Ser Asp Val Leu Ala Gly Trp Ala Ile Gly Ala Leu
130 135 140
Thr Ser Val Val Val Phe Thr Ser Trp Asn Leu Leu Gln Arg Arg
145 150 155
<210> 103
<211> 999
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(976)
<223> RXN02638
<400> 103
ctctgttgtt gttcctgagg cgcttcgtcc attcgtgggc aaagacgtgc tcaagccagt 60
gaaacaagcc ggttaattaa gcggaaagct cgtggtcgac atg gtc aaa agg ttt 115
Met Val Lys Arg Phe
1 5
ggc ttt ttc gta gag gat tcc ctg cct aag gtt ccg ctg cat ccc gaa 163
Gly Phe Phe Val Glu Asp Ser Leu Pro Lys Val Pro Leu His Pro Glu
10 15 20
gag tca cgg gag acg ttt tat ggg cgc atc atc att agt gct gtg cgg 211
Glu Ser Arg Glu Thr Phe Tyr Gly Arg Ile Ile Ile Ser Ala Val Arg
25 30 35
acg gtg atg aaa gcc cag gat gtg cag att tcc atc ttc ggt gcg gag 259
Thr Val Met Lys Ala Gln Asp Val Gln Ile Ser Ile Phe Gly Ala Glu
40 45 50
aac att ccg acc acc ggc ggc gca ctt ttc gca tca acc aca ctg gtt 307
Asn Ile Pro Thr Thr Gly Gly Ala Leu Phe Ala Ser Thr Thr Leu Val
55 60 65
att atg act tca ttc tgg gtg gta tcc ccc gca ttc gtg cgg ggt aag 355
Ile Met Thr Ser Phe Trp Val Val Ser Pro Ala Phe Val Arg Gly Lys
70 75 80 85
cgc ctg gtt cga ttc atg gcg aag aag gaa att ttc gac acc cca gtt 403
Arg Leu Val Arg Phe Met Ala Lys Lys Glu Ile Phe Asp Thr Pro Val
90 95 100
gtc ggc acc ctc atg cgc tgg atg aag cac gtc tct gtg gac cgc tcc 451
Val Gly Thr Leu Met Arg Trp Met Lys His Val Ser Val Asp Arg Ser
105 110 115
gca ggt gcc ggt tcc atg gaa gat gcg cgg aag cgt ctc gac gcc ggc 499
Ala Gly Ala Gly Ser Met Glu Asp Ala Arg Lys Arg Leu Asp Ala Gly
120 125 130
agc ctc gtc ggt atc ttc cct gag gcg acg gtg tca cgg tcc ttt gaa 547
Ser Leu Val Gly Ile Phe Pro Glu Ala Thr Val Ser Arg Ser Phe Glu
135 140 145
atc aag gaa cta aaa act ggc gcc gtc cgc atc gcc gac agc gct aac 595
Ile Lys Glu Leu Lys Thr Gly Ala Val Arg Ile Ala Asp Ser Ala Asn
150 155 160 165
gtt ccg ctg ctg cca ctt att att tgg ggc ggc cag cgc atc atc acc 643
Val Pro Leu Leu Pro Leu Ile Ile Trp Gly Gly Gln Arg Ile Ile Thr
170 175 180
aaa gac atc gag cgc gac ttc ggc cgc tcc cac atc ccc gta ttc atc 691
Lys Asp Ile Glu Arg Asp Phe Gly Arg Ser His Ile Pro Val Phe Ile
185 190 195
agc gtg ggt gaa ccc gtc gac gcc agc ggc gat ccc gac gaa gca acg 739
Ser Val Gly Glu Pro Val Asp Ala Ser Gly Asp Pro Asp Glu Ala Thr
200 205 210
gaa cgc ctc tac gag gct atg aaa aag ctt ctc gac gaa acc cgc acc 787
Glu Arg Leu Tyr Glu Ala Met Lys Lys Leu Leu Asp Glu Thr Arg Thr
215 220 225
gcc tac gaa caa aag tat ggc cca ttc gaa ggt gga gaa ttg tgg cgc 835
Ala Tyr Glu Gln Lys Tyr Gly Pro Phe Glu Gly Gly Glu Leu Trp Arg
230 235 240 245
ccg aaa tcc ctc ggc ggc ggc gcc cca acg ttg gag cag gcg aaa atg 883
Pro Lys Ser Leu Gly Gly Gly Ala Pro Thr Leu Glu Gln Ala Lys Met
250 255 260
ttg gaa atc gcc gaa cgg gaa cgt cga caa gca aaa cgc gcg gca aag 931
Leu Glu Ile Ala Glu Arg Glu Arg Arg Gln Ala Lys Arg Ala Ala Lys
265 270 275
gtc gcc aag aaa cgc acc acc ttt ata agg aaa atc ttt aaa aaa 976
Val Ala Lys Lys Arg Thr Thr Phe Ile Arg Lys Ile Phe Lys Lys
280 285 290
tgattgcact gggttcagcg ccc 999
<210> 104
<211> 292
<212> PRT
<213> Corynebacterium glutamicum
<400> 104
Met Val Lys Arg Phe Gly Phe Phe Val Glu Asp Ser Leu Pro Lys Val
1 5 10 15
Pro Leu His Pro Glu Glu Ser Arg Glu Thr Phe Tyr Gly Arg Ile Ile
20 25 30
Ile Ser Ala Val Arg Thr Val Met Lys Ala Gln Asp Val Gln Ile Ser
35 40 45
Ile Phe Gly Ala Glu Asn Ile Pro Thr Thr Gly Gly Ala Leu Phe Ala
50 55 60
Ser Thr Thr Leu Val Ile Met Thr Ser Phe Trp Val Val Ser Pro Ala
65 70 75 80
Phe Val Arg Gly Lys Arg Leu Val Arg Phe Met Ala Lys Lys Glu Ile
85 90 95
Phe Asp Thr Pro Val Val Gly Thr Leu Met Arg Trp Met Lys His Val
100 105 110
Ser Val Asp Arg Ser Ala Gly Ala Gly Ser Met Glu Asp Ala Arg Lys
115 120 125
Arg Leu Asp Ala Gly Ser Leu Val Gly Ile Phe Pro Glu Ala Thr Val
130 135 140
Ser Arg Ser Phe Glu Ile Lys Glu Leu Lys Thr Gly Ala Val Arg Ile
145 150 155 160
Ala Asp Ser Ala Asn Val Pro Leu Leu Pro Leu Ile Ile Trp Gly Gly
165 170 175
Gln Arg Ile Ile Thr Lys Asp Ile Glu Arg Asp Phe Gly Arg Ser His
180 185 190
Ile Pro Val Phe Ile Ser Val Gly Glu Pro Val Asp Ala Ser Gly Asp
195 200 205
Pro Asp Glu Ala Thr Glu Arg Leu Tyr Glu Ala Met Lys Lys Leu Leu
210 215 220
Asp Glu Thr Arg Thr Ala Tyr Glu Gln Lys Tyr Gly Pro Phe Glu Gly
225 230 235 240
Gly Glu Leu Trp Arg Pro Lys Ser Leu Gly Gly Gly Ala Pro Thr Leu
245 250 255
Glu Gln Ala Lys Met Leu Glu Ile Ala Glu Arg Glu Arg Arg Gln Ala
260 265 270
Lys Arg Ala Ala Lys Val Ala Lys Lys Arg Thr Thr Phe Ile Arg Lys
275 280 285
Ile Phe Lys Lys
290
<210> 105
<211> 534
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (8)..(511)
<223> FRXA02638
<400> 105
atgaaga atg gcg cgg aag cgt ctt aac gcc ggc agc ctc gtc ggt atc 49
Met Ala Arg Lys Arg Leu Asn Ala Gly Ser Leu Val Gly Ile
1 5 10
ttc cct gag gcg acg gtg tca cgg tcc ttt gaa atc aag gaa cta aaa 97
Phe Pro Glu Ala Thr Val Ser Arg Ser Phe Glu Ile Lys Glu Leu Lys
15 20 25 30
act ggc gcc gtc cgc atc gcc gac agc gct aac gtt ccg ctg ctg cca 145
Thr Gly Ala Val Arg Ile Ala Asp Ser Ala Asn Val Pro Leu Leu Pro
35 40 45
ctt att att tgg ggc ggc cag cgc atc atc acc aaa gac atc gag cgc 193
Leu Ile Ile Trp Gly Gly Gln Arg Ile Ile Thr Lys Asp Ile Glu Arg
50 55 60
gac ttc ggc cgc tcc cac atc ccc gta ttc atc agc gtg ggt gaa ccc 241
Asp Phe Gly Arg Ser His Ile Pro Val Phe Ile Ser Val Gly Glu Pro
65 70 75
gtc gac gcc agc ggc gat ccc gac gaa gca acg gaa cgc ctc tac gag 289
Val Asp Ala Ser Gly Asp Pro Asp Glu Ala Thr Glu Arg Leu Tyr Glu
80 85 90
gct atg aaa aag ctt ctc gac gaa acc cgc acc gcc tac gaa caa aag 337
Ala Met Lys Lys Leu Leu Asp Glu Thr Arg Thr Ala Tyr Glu Gln Lys
95 100 105 110
tat ggc cca ttc gaa ggt gga gaa ttg tgg cgc ccg aaa tcc ctc ggc 385
Tyr Gly Pro Phe Glu Gly Gly Glu Leu Trp Arg Pro Lys Ser Leu Gly
115 120 125
ggc ggc gcc cca acg ttg gag cag gcg aaa atg ttg gaa atc gcc gaa 433
Gly Gly Ala Pro Thr Leu Glu Gln Ala Lys Met Leu Glu Ile Ala Glu
130 135 140
cgg gaa cgt cga caa gca aaa cgc gcg gca aag gtc gcc aag aaa cgc 481
Arg Glu Arg Arg Gln Ala Lys Arg Ala Ala Lys Val Ala Lys Lys Arg
145 150 155
acc acc ttt ata agg aaa atc ttt aaa aaa tgattgcact gggttcagcg 531
Thr Thr Phe Ile Arg Lys Ile Phe Lys Lys
160 165
ccc 534
<210> 106
<211> 168
<212> PRT
<213> Corynebacterium glutamicum
<400> 106
Met Ala Arg Lys Arg Leu Asn Ala Gly Ser Leu Val Gly Ile Phe Pro
1 5 10 15
Glu Ala Thr Val Ser Arg Ser Phe Glu Ile Lys Glu Leu Lys Thr Gly
20 25 30
Ala Val Arg Ile Ala Asp Ser Ala Asn Val Pro Leu Leu Pro Leu Ile
35 40 45
Ile Trp Gly Gly Gln Arg Ile Ile Thr Lys Asp Ile Glu Arg Asp Phe
50 55 60
Gly Arg Ser His Ile Pro Val Phe Ile Ser Val Gly Glu Pro Val Asp
65 70 75 80
Ala Ser Gly Asp Pro Asp Glu Ala Thr Glu Arg Leu Tyr Glu Ala Met
85 90 95
Lys Lys Leu Leu Asp Glu Thr Arg Thr Ala Tyr Glu Gln Lys Tyr Gly
100 105 110
Pro Phe Glu Gly Gly Glu Leu Trp Arg Pro Lys Ser Leu Gly Gly Gly
115 120 125
Ala Pro Thr Leu Glu Gln Ala Lys Met Leu Glu Ile Ala Glu Arg Glu
130 135 140
Arg Arg Gln Ala Lys Arg Ala Ala Lys Val Ala Lys Lys Arg Thr Thr
145 150 155 160
Phe Ile Arg Lys Ile Phe Lys Lys
165
<210> 107
<211> 637
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(637)
<223> RXA00856
<400> 107
gtttttagga atagagtggg ctcaagcttt gtgacaagtt ttttggagaa atcattacta 60
gtcgtagtct tcaatttggg tgcaggtagg gtggaacacc gtg agt gat gta tca 115
Val Ser Asp Val Ser
1 5
gca ggc gta aat ggc gca caa gat cca agc aat caa gcg gtc aag cct 163
Ala Gly Val Asn Gly Ala Gln Asp Pro Ser Asn Gln Ala Val Lys Pro
10 15 20
tcc aac tgg aac ctt ccg aac ttc ttg acc agc ttg cgt atc att gtc 211
Ser Asn Trp Asn Leu Pro Asn Phe Leu Thr Ser Leu Arg Ile Ile Val
25 30 35
atc cct ttg ttt gcg tgg ctt acg ctt aaa ggt gag acg gaa aac aat 259
Ile Pro Leu Phe Ala Trp Leu Thr Leu Lys Gly Glu Thr Glu Asn Asn
40 45 50
gct ttt gcc tgg tgg gcg ttg gtt gtt ttc att ttg ctc atg atc acc 307
Ala Phe Ala Trp Trp Ala Leu Val Val Phe Ile Leu Leu Met Ile Thr
55 60 65
gac aag ctt gac ggc gat att gcg cga gca cgt ggc ctg gtc act gac 355
Asp Lys Leu Asp Gly Asp Ile Ala Arg Ala Arg Gly Leu Val Thr Asp
70 75 80 85
ttt ggc aag atc gcg gat ccg att gcc gat aag gcg ttg atg acc aca 403
Phe Gly Lys Ile Ala Asp Pro Ile Ala Asp Lys Ala Leu Met Thr Thr
90 95 100
gca ttt gtc tgt ttc aac atc atc ggc att ttg ccc tgg tgg gtc act 451
Ala Phe Val Cys Phe Asn Ile Ile Gly Ile Leu Pro Trp Trp Val Thr
105 110 115
gcg ttg att gtg ctt cga gag ttc ggc att acc atc tgg cgt ttc ttc 499
Ala Leu Ile Val Leu Arg Glu Phe Gly Ile Thr Ile Trp Arg Phe Phe
120 125 130
caa ctg cgc gct gga aat gtt gtg cct gca tca aag ggg ggc aag ctt 547
Gln Leu Arg Ala Gly Asn Val Val Pro Ala Ser Lys Gly Gly Lys Leu
135 140 145
aag act gct ctg cag act gtt gcc gtt gct ctg tat ctg tgc cct ttc 595
Lys Thr Ala Leu Gln Thr Val Ala Val Ala Leu Tyr Leu Cys Pro Phe
150 155 160 165
cca agt tgg atg gat att cca agc cag atc gtc atg tat gca 637
Pro Ser Trp Met Asp Ile Pro Ser Gln Ile Val Met Tyr Ala
170 175
<210> 108
<211> 179
<212> PRT
<213> Corynebacterium glutamicum
<400> 108
Val Ser Asp Val Ser Ala Gly Val Asn Gly Ala Gln Asp Pro Ser Asn
1 5 10 15
Gln Ala Val Lys Pro Ser Asn Trp Asn Leu Pro Asn Phe Leu Thr Ser
20 25 30
Leu Arg Ile Ile Val Ile Pro Leu Phe Ala Trp Leu Thr Leu Lys Gly
35 40 45
Glu Thr Glu Asn Asn Ala Phe Ala Trp Trp Ala Leu Val Val Phe Ile
50 55 60
Leu Leu Met Ile Thr Asp Lys Leu Asp Gly Asp Ile Ala Arg Ala Arg
65 70 75 80
Gly Leu Val Thr Asp Phe Gly Lys Ile Ala Asp Pro Ile Ala Asp Lys
85 90 95
Ala Leu Met Thr Thr Ala Phe Val Cys Phe Asn Ile Ile Gly Ile Leu
100 105 110
Pro Trp Trp Val Thr Ala Leu Ile Val Leu Arg Glu Phe Gly Ile Thr
115 120 125
Ile Trp Arg Phe Phe Gln Leu Arg Ala Gly Asn Val Val Pro Ala Ser
130 135 140
Lys Gly Gly Lys Leu Lys Thr Ala Leu Gln Thr Val Ala Val Ala Leu
145 150 155 160
Tyr Leu Cys Pro Phe Pro Ser Trp Met Asp Ile Pro Ser Gln Ile Val
165 170 175
Met Tyr Ala
<210> 109
<211> 780
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(757)
<223> RXA02511
<400> 109
ccatgcttgc gcaagcatgg ggcaccattg atggggcacc aggcactgtc gacccaacgc 60
tgacttcagc gatccgtacc gcagcaccga aggagcactg atg ctg gga ctt cat 115
Met Leu Gly Leu His
1 5
gga cgt aag cct gcg cag gtt att gtt gag cct gtt gcc aaa ttg atg 163
Gly Arg Lys Pro Ala Gln Val Ile Val Glu Pro Val Ala Lys Leu Met
10 15 20
atc aag ttg aag gtg acg cct aat cag ctc acc tta gtc agc gct ggc 211
Ile Lys Leu Lys Val Thr Pro Asn Gln Leu Thr Leu Val Ser Ala Gly
25 30 35
ctc acc gtt ggg gtg gct ttg ctg ctg att cct acg ggg cat ttg att 259
Leu Thr Val Gly Val Ala Leu Leu Leu Ile Pro Thr Gly His Leu Ile
40 45 50
tgg gcg gca gtt ttg acg ggc ctg ttt gcg gct ttc gac atg att gat 307
Trp Ala Ala Val Leu Thr Gly Leu Phe Ala Ala Phe Asp Met Ile Asp
55 60 65
ggc acg gtt gct cgc atg caa ggt ggt ggc acc aaa ttt ggt gcc acc 355
Gly Thr Val Ala Arg Met Gln Gly Gly Gly Thr Lys Phe Gly Ala Thr
70 75 80 85
ttg gat gcc acg tgt gac cgc atc act gat ggt gca cta ttt ggt gcg 403
Leu Asp Ala Thr Cys Asp Arg Ile Thr Asp Gly Ala Leu Phe Gly Ala
90 95 100
att acc tgg tgg ctg gtg tat tcc tac gat gca cca cag gca ttg gtc 451
Ile Thr Trp Trp Leu Val Tyr Ser Tyr Asp Ala Pro Gln Ala Leu Val
105 110 115
gct gcc tcc ttg gtt tgt ttg gtt gcc tcc cag gtg atc tct tac gtg 499
Ala Ala Ser Leu Val Cys Leu Val Ala Ser Gln Val Ile Ser Tyr Val
120 125 130
aaa gcc agg gga gag gcc tcc gga ttc acc atg gac ggc ggt ctc gtg 547
Lys Ala Arg Gly Glu Ala Ser Gly Phe Thr Met Asp Gly Gly Leu Val
135 140 145
gaa cgc cct gag cgt ctg att gtc agc ctt gtt ggt ttg ggg ctg acc 595
Glu Arg Pro Glu Arg Leu Ile Val Ser Leu Val Gly Leu Gly Leu Thr
150 155 160 165
gga atg ggc gtt cca tat gcc atc gat gtg gca ctg tgg gcc ctt gca 643
Gly Met Gly Val Pro Tyr Ala Ile Asp Val Ala Leu Trp Ala Leu Ala
170 175 180
gct ggc agt att tac act gtt gtg cag cgc ttg gtc atg gct gga aag 691
Ala Gly Ser Ile Tyr Thr Val Val Gln Arg Leu Val Met Ala Gly Lys
185 190 195
tcc cca ttg gct aag gaa ttt acc aag gca cca gca ggt gcg aag gca 739
Ser Pro Leu Ala Lys Glu Phe Thr Lys Ala Pro Ala Gly Ala Lys Ala
200 205 210
gat tac agc aac acc aaa taaaaattag ccgagggagc atc 780
Asp Tyr Ser Asn Thr Lys
215
<210> 110
<211> 219
<212> PRT
<213> Corynebacterium glutamicum
<400> 110
Met Leu Gly Leu His Gly Arg Lys Pro Ala Gln Val Ile Val Glu Pro
1 5 10 15
Val Ala Lys Leu Met Ile Lys Leu Lys Val Thr Pro Asn Gln Leu Thr
20 25 30
Leu Val Ser Ala Gly Leu Thr Val Gly Val Ala Leu Leu Leu Ile Pro
35 40 45
Thr Gly His Leu Ile Trp Ala Ala Val Leu Thr Gly Leu Phe Ala Ala
50 55 60
Phe Asp Met Ile Asp Gly Thr Val Ala Arg Met Gln Gly Gly Gly Thr
65 70 75 80
Lys Phe Gly Ala Thr Leu Asp Ala Thr Cys Asp Arg Ile Thr Asp Gly
85 90 95
Ala Leu Phe Gly Ala Ile Thr Trp Trp Leu Val Tyr Ser Tyr Asp Ala
100 105 110
Pro Gln Ala Leu Val Ala Ala Ser Leu Val Cys Leu Val Ala Ser Gln
115 120 125
Val Ile Ser Tyr Val Lys Ala Arg Gly Glu Ala Ser Gly Phe Thr Met
130 135 140
Asp Gly Gly Leu Val Glu Arg Pro Glu Arg Leu Ile Val Ser Leu Val
145 150 155 160
Gly Leu Gly Leu Thr Gly Met Gly Val Pro Tyr Ala Ile Asp Val Ala
165 170 175
Leu Trp Ala Leu Ala Ala Gly Ser Ile Tyr Thr Val Val Gln Arg Leu
180 185 190
Val Met Ala Gly Lys Ser Pro Leu Ala Lys Glu Phe Thr Lys Ala Pro
195 200 205
Ala Gly Ala Lys Ala Asp Tyr Ser Asn Thr Lys
210 215
<210> 111
<211> 678
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(655)
<223> RXN02836
<400> 111
ccatcactcg gcttcaccgt ctacggtgct gcccgcagga cagagcgccc ccaaaagctc 60
gcttcagacg ggatccaccc cctcgagatg gacgtcaccg atg aca atc gat gaa 115
Met Thr Ile Asp Glu
1 5
ggc cgt cgc cag ttc gag gtc aat gta ttc ggc gcg atg gcc ctc acc 163
Gly Arg Arg Gln Phe Glu Val Asn Val Phe Gly Ala Met Ala Leu Thr
10 15 20
cga ctc gtc ctg ccc cac atg cag aaa caa aag tgg ggg acg atc gtg 211
Arg Leu Val Leu Pro His Met Gln Lys Gln Lys Trp Gly Thr Ile Val
25 30 35
aac atc aca tcg atg ggc ggg aag atc tac acg cct ctc ggc ggc tgg 259
Asn Ile Thr Ser Met Gly Gly Lys Ile Tyr Thr Pro Leu Gly Gly Trp
40 45 50
tat cac ggc acc aag ttc gcc ctc gag gcc ctc tcg gac gcc ctc cgc 307
Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu Ser Asp Ala Leu Arg
55 60 65
ctg gag gtc gcc cca ttc ggc atc gac gtt gtt gtc atc gaa ccg ggc 355
Leu Glu Val Ala Pro Phe Gly Ile Asp Val Val Val Ile Glu Pro Gly
70 75 80 85
ggc atc gcc acc gag tgg gga gga atc gct gcc gac aat ctc gac gca 403
Gly Ile Ala Thr Glu Trp Gly Gly Ile Ala Ala Asp Asn Leu Asp Ala
90 95 100
gtg tcg aaa gac agc gca tac aag cgc cag gct gac gca gta tcg aag 451
Val Ser Lys Asp Ser Ala Tyr Lys Arg Gln Ala Asp Ala Val Ser Lys
105 110 115
tcg ttg cga tct gag gcg aac agc aac cgc aac tca cca ccg tcg gtt 499
Ser Leu Arg Ser Glu Ala Asn Ser Asn Arg Asn Ser Pro Pro Ser Val
120 125 130
gtc gcc gat gcg att gga aag gcc gtg acg gca cgt cac ccc aag acc 547
Val Ala Asp Ala Ile Gly Lys Ala Val Thr Ala Arg His Pro Lys Thr
135 140 145
cgc tat gcc atc ggc ttc ggt gcc aaa ccg ctg att gcc tcg cgc aac 595
Arg Tyr Ala Ile Gly Phe Gly Ala Lys Pro Leu Ile Ala Ser Arg Asn
150 155 160 165
atc ctc acc gat cgc cag ttc gac cca gtg atc act cga gcg act ggc 643
Ile Leu Thr Asp Arg Gln Phe Asp Pro Val Ile Thr Arg Ala Thr Gly
170 175 180
gtc ccc cgc gac tgaccactct tctgcgcccg tca 678
Val Pro Arg Asp
185
<210> 112
<211> 185
<212> PRT
<213> Corynebacterium glutamicum
<400> 112
Met Thr Ile Asp Glu Gly Arg Arg Gln Phe Glu Val Asn Val Phe Gly
1 5 10 15
Ala Met Ala Leu Thr Arg Leu Val Leu Pro His Met Gln Lys Gln Lys
20 25 30
Trp Gly Thr Ile Val Asn Ile Thr Ser Met Gly Gly Lys Ile Tyr Thr
35 40 45
Pro Leu Gly Gly Trp Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu
50 55 60
Ser Asp Ala Leu Arg Leu Glu Val Ala Pro Phe Gly Ile Asp Val Val
65 70 75 80
Val Ile Glu Pro Gly Gly Ile Ala Thr Glu Trp Gly Gly Ile Ala Ala
85 90 95
Asp Asn Leu Asp Ala Val Ser Lys Asp Ser Ala Tyr Lys Arg Gln Ala
100 105 110
Asp Ala Val Ser Lys Ser Leu Arg Ser Glu Ala Asn Ser Asn Arg Asn
115 120 125
Ser Pro Pro Ser Val Val Ala Asp Ala Ile Gly Lys Ala Val Thr Ala
130 135 140
Arg His Pro Lys Thr Arg Tyr Ala Ile Gly Phe Gly Ala Lys Pro Leu
145 150 155 160
Ile Ala Ser Arg Asn Ile Leu Thr Asp Arg Gln Phe Asp Pro Val Ile
165 170 175
Thr Arg Ala Thr Gly Val Pro Arg Asp
180 185
<210> 113
<211> 406
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(406)
<223> FRXA02836
<400> 113
ccatcactcg gcttcaccgt ctacggtgct gcccgcagga cagagcgccc ccaaaagctc 60
gcttcagacg ggatccaccc cctcgagatg gacgtcaccg atg aca atc gat gaa 115
Met Thr Ile Asp Glu
1 5
ggc cgt cgc cag ttc gag gtc aat gta ttc ggc gcg atg gcc ctc acc 163
Gly Arg Arg Gln Phe Glu Val Asn Val Phe Gly Ala Met Ala Leu Thr
10 15 20
cga ctc gtc ctg ccc cac atg cag aaa caa aag tgg ggg acg atc gtg 211
Arg Leu Val Leu Pro His Met Gln Lys Gln Lys Trp Gly Thr Ile Val
25 30 35
aac atc aca tcg atg ggc ggg aag atc tac acg cct ctc ggc ggc tgg 259
Asn Ile Thr Ser Met Gly Gly Lys Ile Tyr Thr Pro Leu Gly Gly Trp
40 45 50
tat cac ggc acc aag ttc gcc ctc gag gcc ctc tcg gac gcc ctc cgc 307
Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu Ser Asp Ala Leu Arg
55 60 65
ctg gag gtc gcc cca ttc ggc atc gac gtt gtt gtc atc gaa ccg ggc 355
Leu Glu Val Ala Pro Phe Gly Ile Asp Val Val Val Ile Glu Pro Gly
70 75 80 85
ggc atc gcc acc gag tgg gga gga atc gct gcc gac aat ctc gac gca 403
Gly Ile Ala Thr Glu Trp Gly Gly Ile Ala Ala Asp Asn Leu Asp Ala
90 95 100
gtg 406
Val
<210> 114
<211> 102
<212> PRT
<213> Corynebacterium glutamicum
<400> 114
Met Thr Ile Asp Glu Gly Arg Arg Gln Phe Glu Val Asn Val Phe Gly
1 5 10 15
Ala Met Ala Leu Thr Arg Leu Val Leu Pro His Met Gln Lys Gln Lys
20 25 30
Trp Gly Thr Ile Val Asn Ile Thr Ser Met Gly Gly Lys Ile Tyr Thr
35 40 45
Pro Leu Gly Gly Trp Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu
50 55 60
Ser Asp Ala Leu Arg Leu Glu Val Ala Pro Phe Gly Ile Asp Val Val
65 70 75 80
Val Ile Glu Pro Gly Gly Ile Ala Thr Glu Trp Gly Gly Ile Ala Ala
85 90 95
Asp Asn Leu Asp Ala Val
100
<210> 115
<211> 1227
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1204)
<223> RXA02578
<400> 115
ggcaaaaatg aggaacagca cgcccgcaat aatgaggacc gttgcagatc gcttcataaa 60
aacagcccac acctttccgc taaactcgca tgttgaaata atg tct acc caa tca 115
Met Ser Thr Gln Ser
1 5
tat gca ccc atc cgc cat cgc gga ttc atc agc tca ctc gag gga cta 163
Tyr Ala Pro Ile Arg His Arg Gly Phe Ile Ser Ser Leu Glu Gly Leu
10 15 20
cgc gca atc gcc tcc ctg gga gtc ttg gcg acc cac gtt gca ttc caa 211
Arg Ala Ile Ala Ser Leu Gly Val Leu Ala Thr His Val Ala Phe Gln
25 30 35
acc tcc gtc gac ccc gcc agc aac atc ggt gca gta ctc gcg cgt ttc 259
Thr Ser Val Asp Pro Ala Ser Asn Ile Gly Ala Val Leu Ala Arg Phe
40 45 50
gac ttt ttc gtc gcc gtc ttc ttc gcc ctc tcc gcc ttc gtt ctt tgg 307
Asp Phe Phe Val Ala Val Phe Phe Ala Leu Ser Ala Phe Val Leu Trp
55 60 65
cga cgc cgc gcc ggg caa cca gtg gga ctg tac tac ctc aaa cgc cta 355
Arg Arg Arg Ala Gly Gln Pro Val Gly Leu Tyr Tyr Leu Lys Arg Leu
70 75 80 85
gcc cgc atc atg ccc gca tac tgg gca acg gtc att gca gtc ctg ctg 403
Ala Arg Ile Met Pro Ala Tyr Trp Ala Thr Val Ile Ala Val Leu Leu
90 95 100
ttt att ccc acc ggc ccc tgg tta gcc aac ctg acg atg acc caa atc 451
Phe Ile Pro Thr Gly Pro Trp Leu Ala Asn Leu Thr Met Thr Gln Ile
105 110 115
tac tgg cca gac ggg ctc atg aca ggc ctc acc cac ctt tgg tcc ctg 499
Tyr Trp Pro Asp Gly Leu Met Thr Gly Leu Thr His Leu Trp Ser Leu
120 125 130
tgc gtg gaa gtg gcg ttt tac ctg gtg atg ccg ctt ctc gcg tgg gtg 547
Cys Val Glu Val Ala Phe Tyr Leu Val Met Pro Leu Leu Ala Trp Val
135 140 145
ttg gat agg ttt ggt cgg ccg gtg cgc atc ctg ttg att gtt ggt ggg 595
Leu Asp Arg Phe Gly Arg Pro Val Arg Ile Leu Leu Ile Val Gly Gly
150 155 160 165
gca gtg ttg agt ctg gcg tgg ccg tgg att ccc ctt gtg gag cat gcg 643
Ala Val Leu Ser Leu Ala Trp Pro Trp Ile Pro Leu Val Glu His Ala
170 175 180
ttg gac gag ggg tgg gcg aac atg cag atc tgg cca ccc gct tac gct 691
Leu Asp Glu Gly Trp Ala Asn Met Gln Ile Trp Pro Pro Ala Tyr Ala
185 190 195
tgc tgg ttt gca gtc ggc atg atc gcc gca gaa att gaa gga gtt cga 739
Cys Trp Phe Ala Val Gly Met Ile Ala Ala Glu Ile Glu Gly Val Arg
200 205 210
ttc cca cgg gtt ccg agc ttt gtg tgg gtg ggt tta gct tta gtg gtc 787
Phe Pro Arg Val Pro Ser Phe Val Trp Val Gly Leu Ala Leu Val Val
215 220 225
gct tgg atc gcg ggc caa gaa tgg ttc gga cca cta ggt tta gtg cac 835
Ala Trp Ile Ala Gly Gln Glu Trp Phe Gly Pro Leu Gly Leu Val His
230 235 240 245
ccc agc ccc tgg gaa ttc aac tta aga gtc ctc gcg ggc aca ctt ttc 883
Pro Ser Pro Trp Glu Phe Asn Leu Arg Val Leu Ala Gly Thr Leu Phe
250 255 260
gct gta ttt ctg gtg gtt ccc tac gcg ctg ggt acg ccc tct cgg ctt 931
Ala Val Phe Leu Val Val Pro Tyr Ala Leu Gly Thr Pro Ser Arg Leu
265 270 275
ctt gat tcc agt tgg atg aaa acg ctc ggc acc tgg tcg tat tcc atc 979
Leu Asp Ser Ser Trp Met Lys Thr Leu Gly Thr Trp Ser Tyr Ser Ile
280 285 290
ttc ctc tgg cac ctt ccc gtg ctg acg att gtg ttc cca ctg ctc ggg 1027
Phe Leu Trp His Leu Pro Val Leu Thr Ile Val Phe Pro Leu Leu Gly
295 300 305
ttg cct tta ttt agt gga aat ttc ctg ttg gtg ttc atc gtg acg gtc 1075
Leu Pro Leu Phe Ser Gly Asn Phe Leu Leu Val Phe Ile Val Thr Val
310 315 320 325
ttg ttg acg atc cca gtt gcc gcc atc agc tac acc ttc atc gaa gag 1123
Leu Leu Thr Ile Pro Val Ala Ala Ile Ser Tyr Thr Phe Ile Glu Glu
330 335 340
ccc atc agc ggt gga ccc ggc gcg cca ttc agg ctg ggg gtc gtt agg 1171
Pro Ile Ser Gly Gly Pro Gly Ala Pro Phe Arg Leu Gly Val Val Arg
345 350 355
att cac cat ttt tct ggg ggt agg tct gga aaa tgatgaattg gcaccacgtc 1224
Ile His His Phe Ser Gly Gly Arg Ser Gly Lys
360 365
aag 1227
<210> 116
<211> 368
<212> PRT
<213> Corynebacterium glutamicum
<400> 116
Met Ser Thr Gln Ser Tyr Ala Pro Ile Arg His Arg Gly Phe Ile Ser
1 5 10 15
Ser Leu Glu Gly Leu Arg Ala Ile Ala Ser Leu Gly Val Leu Ala Thr
20 25 30
His Val Ala Phe Gln Thr Ser Val Asp Pro Ala Ser Asn Ile Gly Ala
35 40 45
Val Leu Ala Arg Phe Asp Phe Phe Val Ala Val Phe Phe Ala Leu Ser
50 55 60
Ala Phe Val Leu Trp Arg Arg Arg Ala Gly Gln Pro Val Gly Leu Tyr
65 70 75 80
Tyr Leu Lys Arg Leu Ala Arg Ile Met Pro Ala Tyr Trp Ala Thr Val
85 90 95
Ile Ala Val Leu Leu Phe Ile Pro Thr Gly Pro Trp Leu Ala Asn Leu
100 105 110
Thr Met Thr Gln Ile Tyr Trp Pro Asp Gly Leu Met Thr Gly Leu Thr
115 120 125
His Leu Trp Ser Leu Cys Val Glu Val Ala Phe Tyr Leu Val Met Pro
130 135 140
Leu Leu Ala Trp Val Leu Asp Arg Phe Gly Arg Pro Val Arg Ile Leu
145 150 155 160
Leu Ile Val Gly Gly Ala Val Leu Ser Leu Ala Trp Pro Trp Ile Pro
165 170 175
Leu Val Glu His Ala Leu Asp Glu Gly Trp Ala Asn Met Gln Ile Trp
180 185 190
Pro Pro Ala Tyr Ala Cys Trp Phe Ala Val Gly Met Ile Ala Ala Glu
195 200 205
Ile Glu Gly Val Arg Phe Pro Arg Val Pro Ser Phe Val Trp Val Gly
210 215 220
Leu Ala Leu Val Val Ala Trp Ile Ala Gly Gln Glu Trp Phe Gly Pro
225 230 235 240
Leu Gly Leu Val His Pro Ser Pro Trp Glu Phe Asn Leu Arg Val Leu
245 250 255
Ala Gly Thr Leu Phe Ala Val Phe Leu Val Val Pro Tyr Ala Leu Gly
260 265 270
Thr Pro Ser Arg Leu Leu Asp Ser Ser Trp Met Lys Thr Leu Gly Thr
275 280 285
Trp Ser Tyr Ser Ile Phe Leu Trp His Leu Pro Val Leu Thr Ile Val
290 295 300
Phe Pro Leu Leu Gly Leu Pro Leu Phe Ser Gly Asn Phe Leu Leu Val
305 310 315 320
Phe Ile Val Thr Val Leu Leu Thr Ile Pro Val Ala Ala Ile Ser Tyr
325 330 335
Thr Phe Ile Glu Glu Pro Ile Ser Gly Gly Pro Gly Ala Pro Phe Arg
340 345 350
Leu Gly Val Val Arg Ile His His Phe Ser Gly Gly Arg Ser Gly Lys
355 360 365
<210> 117
<211> 924
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(901)
<223> RXA02150
<400> 117
gtgtttttcg gtgggctgcg atgacgcatg tccaccaaaa gagccacccc ttaaagaaat 60
taaaaagtgg ttttggtagc ttcgcagcaa aatacacatc gtg ggt aac gta ttc 115
Val Gly Asn Val Phe
1 5
tta gaa gtt cct aca gca gta aag cgc gaa gaa ggg gta aac cca aac 163
Leu Glu Val Pro Thr Ala Val Lys Arg Glu Glu Gly Val Asn Pro Asn
10 15 20
atc atg aaa aac aac tgg tat cgg ctt ttc aag tat gtg cta att ggc 211
Ile Met Lys Asn Asn Trp Tyr Arg Leu Phe Lys Tyr Val Leu Ile Gly
25 30 35
ccg ttt ttg cgt gtg tac aac cgc ccg gag atc gaa ggc aaa gaa aac 259
Pro Phe Leu Arg Val Tyr Asn Arg Pro Glu Ile Glu Gly Lys Glu Asn
40 45 50
atc cct gca gaa ggt gcc gcg atc atg gcg tcc aac cac gaa gca gtg 307
Ile Pro Ala Glu Gly Ala Ala Ile Met Ala Ser Asn His Glu Ala Val
55 60 65
atg gat tcc ttt tat ttt ccc ctg ctg tgc cca cgg cag ctg acc ttc 355
Met Asp Ser Phe Tyr Phe Pro Leu Leu Cys Pro Arg Gln Leu Thr Phe
70 75 80 85
cca gcg aag gcc gaa tac ttc aca tca cca ggt att aaa ggc aag atg 403
Pro Ala Lys Ala Glu Tyr Phe Thr Ser Pro Gly Ile Lys Gly Lys Met
90 95 100
cag aag tgg ttt ttt act tct gtg ggg caa gta ccc ctg gac cgc acc 451
Gln Lys Trp Phe Phe Thr Ser Val Gly Gln Val Pro Leu Asp Arg Thr
105 110 115
gca gat aat gcc atg gat tct ttg atg aat acc gcc aaa atg gtg ctg 499
Ala Asp Asn Ala Met Asp Ser Leu Met Asn Thr Ala Lys Met Val Leu
120 125 130
gat cgg gga gac ctc ttc ggt att tac cct gaa gga tct cgt tcg ccc 547
Asp Arg Gly Asp Leu Phe Gly Ile Tyr Pro Glu Gly Ser Arg Ser Pro
135 140 145
gat ggt cgc atc tac aag ggc aaa acc gga atg gcc tat gtt gcg atg 595
Asp Gly Arg Ile Tyr Lys Gly Lys Thr Gly Met Ala Tyr Val Ala Met
150 155 160 165
gaa act ggt acg aca gtt atc ccc gtt gcc atg att ggc agc cgg gac 643
Glu Thr Gly Thr Thr Val Ile Pro Val Ala Met Ile Gly Ser Arg Asp
170 175 180
gcg aac cct atc gga agt tgg ttt ccg aaa ccc gca aaa gtc agg atc 691
Ala Asn Pro Ile Gly Ser Trp Phe Pro Lys Pro Ala Lys Val Arg Ile
185 190 195
aag gta gga agc cca att gat ccc ctc gca ttc gtc aaa gaa cat ggg 739
Lys Val Gly Ser Pro Ile Asp Pro Leu Ala Phe Val Lys Glu His Gly
200 205 210
ttg aag cct gga acc tac gaa gca gcg cgc aag ctg aca gat cac gtt 787
Leu Lys Pro Gly Thr Tyr Glu Ala Ala Arg Lys Leu Thr Asp His Val
215 220 225
atg ttc att ctt gct gat ctc act ggt cag ccg tat gtt gat gcg tac 835
Met Phe Ile Leu Ala Asp Leu Thr Gly Gln Pro Tyr Val Asp Ala Tyr
230 235 240 245
tct aaa gat gtg aaa aac gct ctg gag gaa gga aaa gga tac ccg gag 883
Ser Lys Asp Val Lys Asn Ala Leu Glu Glu Gly Lys Gly Tyr Pro Glu
250 255 260
ggc aca gct cct tca cag taatcgggtc ttttctgtta aaa 924
Gly Thr Ala Pro Ser Gln
265
<210> 118
<211> 267
<212> PRT
<213> Corynebacterium glutamicum
<400> 118
Val Gly Asn Val Phe Leu Glu Val Pro Thr Ala Val Lys Arg Glu Glu
1 5 10 15
Gly Val Asn Pro Asn Ile Met Lys Asn Asn Trp Tyr Arg Leu Phe Lys
20 25 30
Tyr Val Leu Ile Gly Pro Phe Leu Arg Val Tyr Asn Arg Pro Glu Ile
35 40 45
Glu Gly Lys Glu Asn Ile Pro Ala Glu Gly Ala Ala Ile Met Ala Ser
50 55 60
Asn His Glu Ala Val Met Asp Ser Phe Tyr Phe Pro Leu Leu Cys Pro
65 70 75 80
Arg Gln Leu Thr Phe Pro Ala Lys Ala Glu Tyr Phe Thr Ser Pro Gly
85 90 95
Ile Lys Gly Lys Met Gln Lys Trp Phe Phe Thr Ser Val Gly Gln Val
100 105 110
Pro Leu Asp Arg Thr Ala Asp Asn Ala Met Asp Ser Leu Met Asn Thr
115 120 125
Ala Lys Met Val Leu Asp Arg Gly Asp Leu Phe Gly Ile Tyr Pro Glu
130 135 140
Gly Ser Arg Ser Pro Asp Gly Arg Ile Tyr Lys Gly Lys Thr Gly Met
145 150 155 160
Ala Tyr Val Ala Met Glu Thr Gly Thr Thr Val Ile Pro Val Ala Met
165 170 175
Ile Gly Ser Arg Asp Ala Asn Pro Ile Gly Ser Trp Phe Pro Lys Pro
180 185 190
Ala Lys Val Arg Ile Lys Val Gly Ser Pro Ile Asp Pro Leu Ala Phe
195 200 205
Val Lys Glu His Gly Leu Lys Pro Gly Thr Tyr Glu Ala Ala Arg Lys
210 215 220
Leu Thr Asp His Val Met Phe Ile Leu Ala Asp Leu Thr Gly Gln Pro
225 230 235 240
Tyr Val Asp Ala Tyr Ser Lys Asp Val Lys Asn Ala Leu Glu Glu Gly
245 250 255
Lys Gly Tyr Pro Glu Gly Thr Ala Pro Ser Gln
260 265
<210> 119
<211> 504
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(481)
<223> RXA00607
<400> 119
cactgccagc aacgccaacg gttgaacccg aaccagaagg cgatgaagac tggcccgaac 60
ccatcaaccc cgcaggcgat aacaaagagg aggcaaaccg atg att ctc gca ctg 115
Met Ile Leu Ala Leu
1 5
aca gtc gcg ata ctt ttc ggt gga ggt gtc tac ctc att cag caa cgc 163
Thr Val Ala Ile Leu Phe Gly Gly Gly Val Tyr Leu Ile Gln Gln Arg
10 15 20
gga atg gtg cgc atc gtc ttc ggc atg tca ctg atc ggc cac gca gcg 211
Gly Met Val Arg Ile Val Phe Gly Met Ser Leu Ile Gly His Ala Ala
25 30 35
aac ctg acc atc ctg tac gcc ggt gtg ccc acg tgg cgc ggc gaa gcc 259
Asn Leu Thr Ile Leu Tyr Ala Gly Val Pro Thr Trp Arg Gly Glu Ala
40 45 50
ttc ccc gac agg acc ccg ctt acc gac gcc gcc gat cca ctc ccc cag 307
Phe Pro Asp Arg Thr Pro Leu Thr Asp Ala Ala Asp Pro Leu Pro Gln
55 60 65
gcc ttc gtc ctc acc gcc atc gtc atc gcg atg gcc acc aca acc atc 355
Ala Phe Val Leu Thr Ala Ile Val Ile Ala Met Ala Thr Thr Thr Ile
70 75 80 85
atg ttg gcc ttg gca gca ctg gga cgc agc gac gac acc cgg tcc atc 403
Met Leu Ala Leu Ala Ala Leu Gly Arg Ser Asp Asp Thr Arg Ser Ile
90 95 100
gaa cca gat gac gat caa tcg cct ttg act act agc gct cgt tca gtc 451
Glu Pro Asp Asp Asp Gln Ser Pro Leu Thr Thr Ser Ala Arg Ser Val
105 110 115
acc aac cca aca gat cag gag gat aaa gct taaatggcca tggatgttct 501
Thr Asn Pro Thr Asp Gln Glu Asp Lys Ala
120 125
cct 504
<210> 120
<211> 127
<212> PRT
<213> Corynebacterium glutamicum
<400> 120
Met Ile Leu Ala Leu Thr Val Ala Ile Leu Phe Gly Gly Gly Val Tyr
1 5 10 15
Leu Ile Gln Gln Arg Gly Met Val Arg Ile Val Phe Gly Met Ser Leu
20 25 30
Ile Gly His Ala Ala Asn Leu Thr Ile Leu Tyr Ala Gly Val Pro Thr
35 40 45
Trp Arg Gly Glu Ala Phe Pro Asp Arg Thr Pro Leu Thr Asp Ala Ala
50 55 60
Asp Pro Leu Pro Gln Ala Phe Val Leu Thr Ala Ile Val Ile Ala Met
65 70 75 80
Ala Thr Thr Thr Ile Met Leu Ala Leu Ala Ala Leu Gly Arg Ser Asp
85 90 95
Asp Thr Arg Ser Ile Glu Pro Asp Asp Asp Gln Ser Pro Leu Thr Thr
100 105 110
Ser Ala Arg Ser Val Thr Asn Pro Thr Asp Gln Glu Asp Lys Ala
115 120 125
<210> 121
<211> 1119
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1096)
<223> RXA02397
<400> 121
gtgtgaataa aacttgtttc ctggtcattt cccctactga actgcgctta tgcctatgct 60
tagaaaccag agacaagctt aagaaggaca ggggccggcc atg aat gat ttc gaa 115
Met Asn Asp Phe Glu
1 5
aca acc atc gat cgg atc tct aaa gaa caa gat ccc gca gcc cga agc 163
Thr Thr Ile Asp Arg Ile Ser Lys Glu Gln Asp Pro Ala Ala Arg Ser
10 15 20
cgc gtg gaa cag ttc att gtg gaa aca gta cgt gca cta ccc aac ttg 211
Arg Val Glu Gln Phe Ile Val Glu Thr Val Arg Ala Leu Pro Asn Leu
25 30 35
acc acc aaa caa ggt gca tcg ttg gct atc caa ctt ctt gat gcg gta 259
Thr Thr Lys Gln Gly Ala Ser Leu Ala Ile Gln Leu Leu Asp Ala Val
40 45 50
cag ctc gcg gat gcg gcg gga acc aag ggg ggt gcg tcg aca agc aat 307
Gln Leu Ala Asp Ala Ala Gly Thr Lys Gly Gly Ala Ser Thr Ser Asn
55 60 65
gct tca tcg ctg cct gac acc ttt gac gcg ctg acc agc ctg att ggc 355
Ala Ser Ser Leu Pro Asp Thr Phe Asp Ala Leu Thr Ser Leu Ile Gly
70 75 80 85
aag ctc gat gtg cgc agc gat tct gaa tgg cgc tcg ttt ggg ttc cag 403
Lys Leu Asp Val Arg Ser Asp Ser Glu Trp Arg Ser Phe Gly Phe Gln
90 95 100
cct tct gaa act gcg cac ccg cta atg atc gct atc cct gag att gag 451
Pro Ser Glu Thr Ala His Pro Leu Met Ile Ala Ile Pro Glu Ile Glu
105 110 115
att ttt tat cag cac acc gat gtg gag ccg gga agc gat gac gcc gtg 499
Ile Phe Tyr Gln His Thr Asp Val Glu Pro Gly Ser Asp Asp Ala Val
120 125 130
gcg ccg gac ttt cag gaa aat cag gat atg tgg cgc agg cgt ctc gga 547
Ala Pro Asp Phe Gln Glu Asn Gln Asp Met Trp Arg Arg Arg Leu Gly
135 140 145
tct gtc acc gaa cca aac ctt ata tat aaa gag ttt tcc gga ccc ggc 595
Ser Val Thr Glu Pro Asn Leu Ile Tyr Lys Glu Phe Ser Gly Pro Gly
150 155 160 165
aaa gcg cag cgt gcc gta gaa atg ctg ggc aat ctg tgg aag atc ggc 643
Lys Ala Gln Arg Ala Val Glu Met Leu Gly Asn Leu Trp Lys Ile Gly
170 175 180
gtg gtg gtg agt agg aat acg gaa agt cgc ctt ggg tta act cgt gtg 691
Val Val Val Ser Arg Asn Thr Glu Ser Arg Leu Gly Leu Thr Arg Val
185 190 195
gaa tac acc ccc acc cct ggc gaa gta ccc gtg ccg ctg atg tcg gag 739
Glu Tyr Thr Pro Thr Pro Gly Glu Val Pro Val Pro Leu Met Ser Glu
200 205 210
aag aac tgt tgg tac agc att cgg gtg tct gaa acc att ggt gag aac 787
Lys Asn Cys Trp Tyr Ser Ile Arg Val Ser Glu Thr Ile Gly Glu Asn
215 220 225
cag gtt ccg gaa att gtg cgc tgc tta ggc gag att ttc tgt ggc tat 835
Gln Val Pro Glu Ile Val Arg Cys Leu Gly Glu Ile Phe Cys Gly Tyr
230 235 240 245
ctt ccc cag atg tgg ctc aaa gaa cca gta aag gcc ggc aag ttg cga 883
Leu Pro Gln Met Trp Leu Lys Glu Pro Val Lys Ala Gly Lys Leu Arg
250 255 260
atc caa gaa tcg gaa gca gca gcg tat atc gcg atg gcg cga cta gat 931
Ile Gln Glu Ser Glu Ala Ala Ala Tyr Ile Ala Met Ala Arg Leu Asp
265 270 275
ctt tcc cca cgc acc ggc aac acc act tgg acc aac agc tat att tcc 979
Leu Ser Pro Arg Thr Gly Asn Thr Thr Trp Thr Asn Ser Tyr Ile Ser
280 285 290
acg cgt cct ctc tcc ccc gct ttt agg tgg gac gtg gtg ctg gag gct 1027
Thr Arg Pro Leu Ser Pro Ala Phe Arg Trp Asp Val Val Leu Glu Ala
295 300 305
tcc cac caa ttg gag aac ctg ctg cgt gga gac aca ggg ccg gtc act 1075
Ser His Gln Leu Glu Asn Leu Leu Arg Gly Asp Thr Gly Pro Val Thr
310 315 320 325
gcc aca caa tcg gca gct ggt taaccaaaag ttcacgtgga gat 1119
Ala Thr Gln Ser Ala Ala Gly
330
<210> 122
<211> 332
<212> PRT
<213> Corynebacterium glutamicum
<400> 122
Met Asn Asp Phe Glu Thr Thr Ile Asp Arg Ile Ser Lys Glu Gln Asp
1 5 10 15
Pro Ala Ala Arg Ser Arg Val Glu Gln Phe Ile Val Glu Thr Val Arg
20 25 30
Ala Leu Pro Asn Leu Thr Thr Lys Gln Gly Ala Ser Leu Ala Ile Gln
35 40 45
Leu Leu Asp Ala Val Gln Leu Ala Asp Ala Ala Gly Thr Lys Gly Gly
50 55 60
Ala Ser Thr Ser Asn Ala Ser Ser Leu Pro Asp Thr Phe Asp Ala Leu
65 70 75 80
Thr Ser Leu Ile Gly Lys Leu Asp Val Arg Ser Asp Ser Glu Trp Arg
85 90 95
Ser Phe Gly Phe Gln Pro Ser Glu Thr Ala His Pro Leu Met Ile Ala
100 105 110
Ile Pro Glu Ile Glu Ile Phe Tyr Gln His Thr Asp Val Glu Pro Gly
115 120 125
Ser Asp Asp Ala Val Ala Pro Asp Phe Gln Glu Asn Gln Asp Met Trp
130 135 140
Arg Arg Arg Leu Gly Ser Val Thr Glu Pro Asn Leu Ile Tyr Lys Glu
145 150 155 160
Phe Ser Gly Pro Gly Lys Ala Gln Arg Ala Val Glu Met Leu Gly Asn
165 170 175
Leu Trp Lys Ile Gly Val Val Val Ser Arg Asn Thr Glu Ser Arg Leu
180 185 190
Gly Leu Thr Arg Val Glu Tyr Thr Pro Thr Pro Gly Glu Val Pro Val
195 200 205
Pro Leu Met Ser Glu Lys Asn Cys Trp Tyr Ser Ile Arg Val Ser Glu
210 215 220
Thr Ile Gly Glu Asn Gln Val Pro Glu Ile Val Arg Cys Leu Gly Glu
225 230 235 240
Ile Phe Cys Gly Tyr Leu Pro Gln Met Trp Leu Lys Glu Pro Val Lys
245 250 255
Ala Gly Lys Leu Arg Ile Gln Glu Ser Glu Ala Ala Ala Tyr Ile Ala
260 265 270
Met Ala Arg Leu Asp Leu Ser Pro Arg Thr Gly Asn Thr Thr Trp Thr
275 280 285
Asn Ser Tyr Ile Ser Thr Arg Pro Leu Ser Pro Ala Phe Arg Trp Asp
290 295 300
Val Val Leu Glu Ala Ser His Gln Leu Glu Asn Leu Leu Arg Gly Asp
305 310 315 320
Thr Gly Pro Val Thr Ala Thr Gln Ser Ala Ala Gly
325 330
<210> 123
<211> 1462
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1462)
<223> RXN03110
<400> 123
aatgagtgaa cctgcgcttg aactataccc cctggggtat tactgtagat tctcaatacc 60
ccgaggggta tctagttttt acgttgagaa ggagagctca gtg ctt att gaa cgc 115
Val Leu Ile Glu Arg
1 5
atc tac gac gaa gac ctt gcg cag gcc agc tat ttc att ggc tgc caa 163
Ile Tyr Asp Glu Asp Leu Ala Gln Ala Ser Tyr Phe Ile Gly Cys Gln
10 15 20
gcc cac aac acc gca gtc gtg gtt gat ccg cgt cgc gat att gcc gtc 211
Ala His Asn Thr Ala Val Val Val Asp Pro Arg Arg Asp Ile Ala Val
25 30 35
tat ctg gac atg gcc aag aaa aac gga atg gag att gtt gga gtt acc 259
Tyr Leu Asp Met Ala Lys Lys Asn Gly Met Glu Ile Val Gly Val Thr
40 45 50
gaa acc cat atc cat gcg gac tat ttg tca gga acc cgt gag tta gct 307
Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly Thr Arg Glu Leu Ala
55 60 65
gct gca act aat gcc acc atg tac gtc tca ggg gag ggc ggc gcc gat 355
Ala Ala Thr Asn Ala Thr Met Tyr Val Ser Gly Glu Gly Gly Ala Asp
70 75 80 85
tgg cag tat gaa ttc gac gcc gag cga ata tgc gac ggc agc gag att 403
Trp Gln Tyr Glu Phe Asp Ala Glu Arg Ile Cys Asp Gly Ser Glu Ile
90 95 100
cgc ctg gga aat ctg gtg ctc aca gct gtt cac acc cca ggc cat acc 451
Arg Leu Gly Asn Leu Val Leu Thr Ala Val His Thr Pro Gly His Thr
105 110 115
ccg gaa cac tta tcg ttc ctg ctg aag gac ggc gcg ttc gca gat gag 499
Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly Ala Phe Ala Asp Glu
120 125 130
cca gga ttc atg ctc act ggc gat ttc gtt ttc gcg ggt gat ctt ggc 547
Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe Ala Gly Asp Leu Gly
135 140 145
cga cca gat ttg ctc gat gaa gca gct ggg gga gtg gac act cgt ttt 595
Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val Asp Thr Arg Phe
150 155 160 165
gag ggg gct cgc caa atg ttc aag agc ttg aag gaa aaa ttc ctg aca 643
Glu Gly Ala Arg Gln Met Phe Lys Ser Leu Lys Glu Lys Phe Leu Thr
170 175 180
ttg cct gat cac atc cag atc ttc cct ggt cat ggt tcc ggt tcc gcg 691
Leu Pro Asp His Ile Gln Ile Phe Pro Gly His Gly Ser Gly Ser Ala
185 190 195
tgt ggc aaa gcc ttg ggt tcg gtt cct tca aca aca ctt gga tat gaa 739
Cys Gly Lys Ala Leu Gly Ser Val Pro Ser Thr Thr Leu Gly Tyr Glu
200 205 210
cgt caa ttt gcg tgg tgg gga aag tat ctg gag gca gat gat gaa caa 787
Arg Gln Phe Ala Trp Trp Gly Lys Tyr Leu Glu Ala Asp Asp Glu Gln
215 220 225
gga ttc att gat gag ctt ctg gaa ggc caa cct gat gca cct gca tac 835
Gly Phe Ile Asp Glu Leu Leu Glu Gly Gln Pro Asp Ala Pro Ala Tyr
230 235 240 245
ttc ggc agg atg aag agg caa aat agg caa ggg ccc gca att atg ggc 883
Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly Pro Ala Ile Met Gly
250 255 260
gct cgc gag ctg ttg cca cag ctg gaa gct tct gat ctg cac gac gtc 931
Ala Arg Glu Leu Leu Pro Gln Leu Glu Ala Ser Asp Leu His Asp Val
265 270 275
att gtt gtt gat acc cgc tca gcc gat gaa gtt cac cag ggc act gta 979
Ile Val Val Asp Thr Arg Ser Ala Asp Glu Val His Gln Gly Thr Val
280 285 290
gct ggt gca gtg aat att cct gcg ggc aat tcg atg gcg aaa ttt ggc 1027
Ala Gly Ala Val Asn Ile Pro Ala Gly Asn Ser Met Ala Lys Phe Gly
295 300 305
tcg tgg acc gtt gat ccc gag aag gat tcc cga gct ttg gtt ctg ctc 1075
Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg Ala Leu Val Leu Leu
310 315 320 325
gcg gca agc caa att ggt gcc atg gag atg tgg gac cac atg gtt cgc 1123
Ala Ala Ser Gln Ile Gly Ala Met Glu Met Trp Asp His Met Val Arg
330 335 340
gtg gga atc gat aat gtt gct ggt ttt atc acc aac ttt gat ggg gtg 1171
Val Gly Ile Asp Asn Val Ala Gly Phe Ile Thr Asn Phe Asp Gly Val
345 350 355
gac cta gtt gca ccg caa act gtg tcc cca gat cag ctg gat gaa ttg 1219
Asp Leu Val Ala Pro Gln Thr Val Ser Pro Asp Gln Leu Asp Glu Leu
360 365 370
gaa tac gat cta ctt ctt gat gtc cgc aac cgc agt gaa gtc gaa gaa 1267
Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg Ser Glu Val Glu Glu
375 380 385
ggc tac atc cca gga gca ctc cat att aat ggt gca tcc gtg ctg tgg 1315
Gly Tyr Ile Pro Gly Ala Leu His Ile Asn Gly Ala Ser Val Leu Trp
390 395 400 405
aat ctg gag aaa ctg cca cgt gac gga aag atc gtg agc tac tgc aag 1363
Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys Ile Val Ser Tyr Cys Lys
410 415 420
agt gga aca cgc agc tca atc gcc gca agc acc ctg cgt aat gct ggt 1411
Ser Gly Thr Arg Ser Ser Ile Ala Ala Ser Thr Leu Arg Asn Ala Gly
425 430 435
ttt gat gtg gtg gaa ctt caa gga tcc tat gac aac tgg gtc cgg cac 1459
Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp Asn Trp Val Arg His
440 445 450
aac 1462
Asn
<210> 124
<211> 454
<212> PRT
<213> Corynebacterium glutamicum
<400> 124
Val Leu Ile Glu Arg Ile Tyr Asp Glu Asp Leu Ala Gln Ala Ser Tyr
1 5 10 15
Phe Ile Gly Cys Gln Ala His Asn Thr Ala Val Val Val Asp Pro Arg
20 25 30
Arg Asp Ile Ala Val Tyr Leu Asp Met Ala Lys Lys Asn Gly Met Glu
35 40 45
Ile Val Gly Val Thr Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly
50 55 60
Thr Arg Glu Leu Ala Ala Ala Thr Asn Ala Thr Met Tyr Val Ser Gly
65 70 75 80
Glu Gly Gly Ala Asp Trp Gln Tyr Glu Phe Asp Ala Glu Arg Ile Cys
85 90 95
Asp Gly Ser Glu Ile Arg Leu Gly Asn Leu Val Leu Thr Ala Val His
100 105 110
Thr Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly
115 120 125
Ala Phe Ala Asp Glu Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe
130 135 140
Ala Gly Asp Leu Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly
145 150 155 160
Val Asp Thr Arg Phe Glu Gly Ala Arg Gln Met Phe Lys Ser Leu Lys
165 170 175
Glu Lys Phe Leu Thr Leu Pro Asp His Ile Gln Ile Phe Pro Gly His
180 185 190
Gly Ser Gly Ser Ala Cys Gly Lys Ala Leu Gly Ser Val Pro Ser Thr
195 200 205
Thr Leu Gly Tyr Glu Arg Gln Phe Ala Trp Trp Gly Lys Tyr Leu Glu
210 215 220
Ala Asp Asp Glu Gln Gly Phe Ile Asp Glu Leu Leu Glu Gly Gln Pro
225 230 235 240
Asp Ala Pro Ala Tyr Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly
245 250 255
Pro Ala Ile Met Gly Ala Arg Glu Leu Leu Pro Gln Leu Glu Ala Ser
260 265 270
Asp Leu His Asp Val Ile Val Val Asp Thr Arg Ser Ala Asp Glu Val
275 280 285
His Gln Gly Thr Val Ala Gly Ala Val Asn Ile Pro Ala Gly Asn Ser
290 295 300
Met Ala Lys Phe Gly Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg
305 310 315 320
Ala Leu Val Leu Leu Ala Ala Ser Gln Ile Gly Ala Met Glu Met Trp
325 330 335
Asp His Met Val Arg Val Gly Ile Asp Asn Val Ala Gly Phe Ile Thr
340 345 350
Asn Phe Asp Gly Val Asp Leu Val Ala Pro Gln Thr Val Ser Pro Asp
355 360 365
Gln Leu Asp Glu Leu Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg
370 375 380
Ser Glu Val Glu Glu Gly Tyr Ile Pro Gly Ala Leu His Ile Asn Gly
385 390 395 400
Ala Ser Val Leu Trp Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys Ile
405 410 415
Val Ser Tyr Cys Lys Ser Gly Thr Arg Ser Ser Ile Ala Ala Ser Thr
420 425 430
Leu Arg Asn Ala Gly Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp
435 440 445
Asn Trp Val Arg His Asn
450
<210> 125
<211> 1023
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(1023)
<223> FRXA00660
<400> 125
cca ggc cat acc ccg gaa cac tta tcg ttc ctg ctg aag gac ggc gcg 48
Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly Ala
1 5 10 15
ttc gca cat gag cca gga ttc atg ctc act ggc gat ttc gtt ttc gcg 96
Phe Ala His Glu Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe Ala
20 25 30
ggt gat ctt ggc cga cca gat ttg ctc gat gaa gca gct ggg gga gtg 144
Gly Asp Leu Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val
35 40 45
gac act cgt ttt gag ggg gct cgc caa atg ttc aag agc ttg aag gaa 192
Asp Thr Arg Phe Glu Gly Ala Arg Gln Met Phe Lys Ser Leu Lys Glu
50 55 60
aaa ttc ctg aca ttg cct gat cac atc cag atc ttc cct ggt cat ggt 240
Lys Phe Leu Thr Leu Pro Asp His Ile Gln Ile Phe Pro Gly His Gly
65 70 75 80
tcc ggt tcc gcg tgt ggc aaa gcc ttg ggt tcg gtt cct tca aca aca 288
Ser Gly Ser Ala Cys Gly Lys Ala Leu Gly Ser Val Pro Ser Thr Thr
85 90 95
ctt gga tat gaa cgt caa ttt gcg tgg tgg gga aag tat ctg gag gca 336
Leu Gly Tyr Glu Arg Gln Phe Ala Trp Trp Gly Lys Tyr Leu Glu Ala
100 105 110
gat gat gaa caa gga ttc att gat gag ctt ctg gaa ggc caa cct gat 384
Asp Asp Glu Gln Gly Phe Ile Asp Glu Leu Leu Glu Gly Gln Pro Asp
115 120 125
gca cct gca tac ttc ggc agg atg aag agg caa aat agg caa ggg ccc 432
Ala Pro Ala Tyr Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly Pro
130 135 140
gca att atg ggc gct cgc gag ctg ttg cca cag ctg gaa gct tct gat 480
Ala Ile Met Gly Ala Arg Glu Leu Leu Pro Gln Leu Glu Ala Ser Asp
145 150 155 160
ctg cac gac gtc att gtt gtt gat acc cgc tca gcc gat gaa gtt cac 528
Leu His Asp Val Ile Val Val Asp Thr Arg Ser Ala Asp Glu Val His
165 170 175
cag ggc act gta gct ggt gca gtg aat att cct gcg ggc aat tcg atg 576
Gln Gly Thr Val Ala Gly Ala Val Asn Ile Pro Ala Gly Asn Ser Met
180 185 190
gcg aaa ttt ggc tcg tgg acc gtt gat ccc gag aag gat tcc cga gct 624
Ala Lys Phe Gly Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg Ala
195 200 205
ttg gtt ctg ctc gcg gca agc caa att ggt gcc atg gag atg tgg gac 672
Leu Val Leu Leu Ala Ala Ser Gln Ile Gly Ala Met Glu Met Trp Asp
210 215 220
cac atg gtt cgc gtg gga atc gat aat gtt gct ggt ttt atc acc aac 720
His Met Val Arg Val Gly Ile Asp Asn Val Ala Gly Phe Ile Thr Asn
225 230 235 240
ttt gat ggg gtg gac cta gtt gca ccg caa act gtg tcc cca gat cag 768
Phe Asp Gly Val Asp Leu Val Ala Pro Gln Thr Val Ser Pro Asp Gln
245 250 255
ctg gat gaa ttg gaa tac gat cta ctt ctt gat gtc cgc aac cgc agt 816
Leu Asp Glu Leu Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg Ser
260 265 270
gaa gtc gaa gaa ggc tac atc cca gga gca ctc cat att aat ggt gca 864
Glu Val Glu Glu Gly Tyr Ile Pro Gly Ala Leu His Ile Asn Gly Ala
275 280 285
tcc gtg ctg tgg aat ctg gag aaa ctg cca cgt gac gga aag atc gtg 912
Ser Val Leu Trp Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys Ile Val
290 295 300
agc tac tgc aag agt gga aca cgc agc tca atc gcc gca agc acc ctg 960
Ser Tyr Cys Lys Ser Gly Thr Arg Ser Ser Ile Ala Ala Ser Thr Leu
305 310 315 320
cgt aat gct ggt ttt gat gtg gtg gaa ctt caa gga tcc tat gac aac 1008
Arg Asn Ala Gly Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp Asn
325 330 335
tgg gtc cgg cac aac 1023
Trp Val Arg His Asn
340
<210> 126
<211> 341
<212> PRT
<213> Corynebacterium glutamicum
<400> 126
Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly Ala
1 5 10 15
Phe Ala His Glu Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe Ala
20 25 30
Gly Asp Leu Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val
35 40 45
Asp Thr Arg Phe Glu Gly Ala Arg Gln Met Phe Lys Ser Leu Lys Glu
50 55 60
Lys Phe Leu Thr Leu Pro Asp His Ile Gln Ile Phe Pro Gly His Gly
65 70 75 80
Ser Gly Ser Ala Cys Gly Lys Ala Leu Gly Ser Val Pro Ser Thr Thr
85 90 95
Leu Gly Tyr Glu Arg Gln Phe Ala Trp Trp Gly Lys Tyr Leu Glu Ala
100 105 110
Asp Asp Glu Gln Gly Phe Ile Asp Glu Leu Leu Glu Gly Gln Pro Asp
115 120 125
Ala Pro Ala Tyr Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly Pro
130 135 140
Ala Ile Met Gly Ala Arg Glu Leu Leu Pro Gln Leu Glu Ala Ser Asp
145 150 155 160
Leu His Asp Val Ile Val Val Asp Thr Arg Ser Ala Asp Glu Val His
165 170 175
Gln Gly Thr Val Ala Gly Ala Val Asn Ile Pro Ala Gly Asn Ser Met
180 185 190
Ala Lys Phe Gly Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg Ala
195 200 205
Leu Val Leu Leu Ala Ala Ser Gln Ile Gly Ala Met Glu Met Trp Asp
210 215 220
His Met Val Arg Val Gly Ile Asp Asn Val Ala Gly Phe Ile Thr Asn
225 230 235 240
Phe Asp Gly Val Asp Leu Val Ala Pro Gln Thr Val Ser Pro Asp Gln
245 250 255
Leu Asp Glu Leu Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg Ser
260 265 270
Glu Val Glu Glu Gly Tyr Ile Pro Gly Ala Leu His Ile Asn Gly Ala
275 280 285
Ser Val Leu Trp Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys Ile Val
290 295 300
Ser Tyr Cys Lys Ser Gly Thr Arg Ser Ser Ile Ala Ala Ser Thr Leu
305 310 315 320
Arg Asn Ala Gly Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp Asn
325 330 335
Trp Val Arg His Asn
340
<210> 127
<211> 756
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(733)
<223> RXA00801
<400> 127
ggataagttt gtttctgagc gtattggtct tgatgatgtt gaagaggctt tcaacaccat 60
gaaggctggc gacgtgctgc gttctgtggt ggagatctaa atg gct cac gac gga 115
Met Ala His Asp Gly
1 5
ttg cgc gta gaa aac att gtc acc tca ggc atc ttt gcc ctt gat ggt 163
Leu Arg Val Glu Asn Ile Val Thr Ser Gly Ile Phe Ala Leu Asp Gly
10 15 20
ggc gaa tgg gaa gtc gac aac aac atc tgg gtt gtg gga aat gat gat 211
Gly Glu Trp Glu Val Asp Asn Asn Ile Trp Val Val Gly Asn Asp Asp
25 30 35
gag gtt ttc atc atc gat gcg gca cac act gca gca ccc atc atc gag 259
Glu Val Phe Ile Ile Asp Ala Ala His Thr Ala Ala Pro Ile Ile Glu
40 45 50
gct gtc ggt gga cgt gct gtg aag ggc att ttg tgc acc cac gca cac 307
Ala Val Gly Gly Arg Ala Val Lys Gly Ile Leu Cys Thr His Ala His
55 60 65
aat gac cac atc act gtc gca cca gag cta tcc aag gaa ttt gat gca 355
Asn Asp His Ile Thr Val Ala Pro Glu Leu Ser Lys Glu Phe Asp Ala
70 75 80 85
cca atc ttc gtg cac cca ggt gac caa atg ctg tgg gag gaa acc cac 403
Pro Ile Phe Val His Pro Gly Asp Gln Met Leu Trp Glu Glu Thr His
90 95 100
gga aac ctg acc cac gag gat ttg gca gat cag cag aag ttc caa atc 451
Gly Asn Leu Thr His Glu Asp Leu Ala Asp Gln Gln Lys Phe Gln Ile
105 110 115
gct gga act gaa ctg atc gtg ctt aat acc cct gga cac tca cct gga 499
Ala Gly Thr Glu Leu Ile Val Leu Asn Thr Pro Gly His Ser Pro Gly
120 125 130
tcc agc tgc ttc tac ctc cct gaa gca aac gag ctc ttc tct gga gac 547
Ser Ser Cys Phe Tyr Leu Pro Glu Ala Asn Glu Leu Phe Ser Gly Asp
135 140 145
act ttg ttc cag ggt ggg ccg gga gca act ggc cgt aag tac agc tcc 595
Thr Leu Phe Gln Gly Gly Pro Gly Ala Thr Gly Arg Lys Tyr Ser Ser
150 155 160 165
ttt gac acc atc att gag tcc ctc aag acc tca att ttg gat cta cca 643
Phe Asp Thr Ile Ile Glu Ser Leu Lys Thr Ser Ile Leu Asp Leu Pro
170 175 180
gcg gaa acc acc gtg cgc act ggc cat ggt gat cac acc agt gtg ggg 691
Ala Glu Thr Thr Val Arg Thr Gly His Gly Asp His Thr Ser Val Gly
185 190 195
gct gag gct cca cac ttg gag gaa tgg att aaa cgc ggg cac 733
Ala Glu Ala Pro His Leu Glu Glu Trp Ile Lys Arg Gly His
200 205 210
taagccccga acgattagta ggc 756
<210> 128
<211> 211
<212> PRT
<213> Corynebacterium glutamicum
<400> 128
Met Ala His Asp Gly Leu Arg Val Glu Asn Ile Val Thr Ser Gly Ile
1 5 10 15
Phe Ala Leu Asp Gly Gly Glu Trp Glu Val Asp Asn Asn Ile Trp Val
20 25 30
Val Gly Asn Asp Asp Glu Val Phe Ile Ile Asp Ala Ala His Thr Ala
35 40 45
Ala Pro Ile Ile Glu Ala Val Gly Gly Arg Ala Val Lys Gly Ile Leu
50 55 60
Cys Thr His Ala His Asn Asp His Ile Thr Val Ala Pro Glu Leu Ser
65 70 75 80
Lys Glu Phe Asp Ala Pro Ile Phe Val His Pro Gly Asp Gln Met Leu
85 90 95
Trp Glu Glu Thr His Gly Asn Leu Thr His Glu Asp Leu Ala Asp Gln
100 105 110
Gln Lys Phe Gln Ile Ala Gly Thr Glu Leu Ile Val Leu Asn Thr Pro
115 120 125
Gly His Ser Pro Gly Ser Ser Cys Phe Tyr Leu Pro Glu Ala Asn Glu
130 135 140
Leu Phe Ser Gly Asp Thr Leu Phe Gln Gly Gly Pro Gly Ala Thr Gly
145 150 155 160
Arg Lys Tyr Ser Ser Phe Asp Thr Ile Ile Glu Ser Leu Lys Thr Ser
165 170 175
Ile Leu Asp Leu Pro Ala Glu Thr Thr Val Arg Thr Gly His Gly Asp
180 185 190
His Thr Ser Val Gly Ala Glu Ala Pro His Leu Glu Glu Trp Ile Lys
195 200 205
Arg Gly His
210
<210> 129
<211> 966
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(943)
<223> RXA00821
<400> 129
ttaaaagctt gcttctcgac gcaaaaaccc atccggcgca tcccttcaat gttaggggtg 60
cgctgctatt tttctcccca gttctacgaa atgacttatt gtg act aag ctt gag 115
Val Thr Lys Leu Glu
1 5
cgc atg gag cat cct gct tac agc caa ttg cgg ccg gtt acc ccg tcc 163
Arg Met Glu His Pro Ala Tyr Ser Gln Leu Arg Pro Val Thr Pro Ser
10 15 20
gca tct gtt gtt ttg tgc cct aat ccc ggt tac agc tcg ctg gaa ggc 211
Ala Ser Val Val Leu Cys Pro Asn Pro Gly Tyr Ser Ser Leu Glu Gly
25 30 35
act aat tct tgg gtt atc cgg gca cca gaa gac ccc cgg agc att gtc 259
Thr Asn Ser Trp Val Ile Arg Ala Pro Glu Asp Pro Arg Ser Ile Val
40 45 50
atc gat cca ggt cct gaa gat gag ggc cac ctt aac gtc ttg cat tcc 307
Ile Asp Pro Gly Pro Glu Asp Glu Gly His Leu Asn Val Leu His Ser
55 60 65
aag gct gag gag gtg ggt ttg att ctt ctg acc cac cgt cac tat gat 355
Lys Ala Glu Glu Val Gly Leu Ile Leu Leu Thr His Arg His Tyr Asp
70 75 80 85
cat gct gac ggc gca cag cgt ttc cgt cag ctg acc aat gca cct gtg 403
His Ala Asp Gly Ala Gln Arg Phe Arg Gln Leu Thr Asn Ala Pro Val
90 95 100
cgt gcg atg gac cct tcg tac tgt gct ggt gcg gag gag att cat gat 451
Arg Ala Met Asp Pro Ser Tyr Cys Ala Gly Ala Glu Glu Ile His Asp
105 110 115
ggt gag atc atc acg atc gac ggt gtc acc cca cag att gag gtg gtg 499
Gly Glu Ile Ile Thr Ile Asp Gly Val Thr Pro Gln Ile Glu Val Val
120 125 130
gcc aca cct ggt cat acc cgt gat tct gtg tct tat ttc atc tgg agt 547
Ala Thr Pro Gly His Thr Arg Asp Ser Val Ser Tyr Phe Ile Trp Ser
135 140 145
gga gtc cct cat gag tcc act ttg gag ggc atc gtt tct ggc gac acc 595
Gly Val Pro His Glu Ser Thr Leu Glu Gly Ile Val Ser Gly Asp Thr
150 155 160 165
att gcg ggt cgt cac acc acg atg att tca gag acc gac ggc gat ttg 643
Ile Ala Gly Arg His Thr Thr Met Ile Ser Glu Thr Asp Gly Asp Leu
170 175 180
ggt gag tac ctg aat tct ttg gcc att ttg gag gag cgc ggc aag gat 691
Gly Glu Tyr Leu Asn Ser Leu Ala Ile Leu Glu Glu Arg Gly Lys Asp
185 190 195
att ccg ctg ctt cca gga cat ggt cca gat gga cag gac gtg tcc tcc 739
Ile Pro Leu Leu Pro Gly His Gly Pro Asp Gly Gln Asp Val Ser Ser
200 205 210
ttc gcg cgt aag tac att gag cgt cgt gag ctg cgt ctg aac cag atc 787
Phe Ala Arg Lys Tyr Ile Glu Arg Arg Glu Leu Arg Leu Asn Gln Ile
215 220 225
cgt gag gta tgg gag acc cgt ggc cgt gac gtg tcc atg aag gat ctc 835
Arg Glu Val Trp Glu Thr Arg Gly Arg Asp Val Ser Met Lys Asp Leu
230 235 240 245
atc gac gcc atc tac gat gat gtt gat cca gtt ctg cgt ggt gca gcc 883
Ile Asp Ala Ile Tyr Asp Asp Val Asp Pro Val Leu Arg Gly Ala Ala
250 255 260
gag cag tcc act cat gtg gct att cgt tac ctg cag gct cag gaa gct 931
Glu Gln Ser Thr His Val Ala Ile Arg Tyr Leu Gln Ala Gln Glu Ala
265 270 275
tcc gcc tca aac taaacacttt taactaaaca aca 966
Ser Ala Ser Asn
280
<210> 130
<211> 281
<212> PRT
<213> Corynebacterium glutamicum
<400> 130
Val Thr Lys Leu Glu Arg Met Glu His Pro Ala Tyr Ser Gln Leu Arg
1 5 10 15
Pro Val Thr Pro Ser Ala Ser Val Val Leu Cys Pro Asn Pro Gly Tyr
20 25 30
Ser Ser Leu Glu Gly Thr Asn Ser Trp Val Ile Arg Ala Pro Glu Asp
35 40 45
Pro Arg Ser Ile Val Ile Asp Pro Gly Pro Glu Asp Glu Gly His Leu
50 55 60
Asn Val Leu His Ser Lys Ala Glu Glu Val Gly Leu Ile Leu Leu Thr
65 70 75 80
His Arg His Tyr Asp His Ala Asp Gly Ala Gln Arg Phe Arg Gln Leu
85 90 95
Thr Asn Ala Pro Val Arg Ala Met Asp Pro Ser Tyr Cys Ala Gly Ala
100 105 110
Glu Glu Ile His Asp Gly Glu Ile Ile Thr Ile Asp Gly Val Thr Pro
115 120 125
Gln Ile Glu Val Val Ala Thr Pro Gly His Thr Arg Asp Ser Val Ser
130 135 140
Tyr Phe Ile Trp Ser Gly Val Pro His Glu Ser Thr Leu Glu Gly Ile
145 150 155 160
Val Ser Gly Asp Thr Ile Ala Gly Arg His Thr Thr Met Ile Ser Glu
165 170 175
Thr Asp Gly Asp Leu Gly Glu Tyr Leu Asn Ser Leu Ala Ile Leu Glu
180 185 190
Glu Arg Gly Lys Asp Ile Pro Leu Leu Pro Gly His Gly Pro Asp Gly
195 200 205
Gln Asp Val Ser Ser Phe Ala Arg Lys Tyr Ile Glu Arg Arg Glu Leu
210 215 220
Arg Leu Asn Gln Ile Arg Glu Val Trp Glu Thr Arg Gly Arg Asp Val
225 230 235 240
Ser Met Lys Asp Leu Ile Asp Ala Ile Tyr Asp Asp Val Asp Pro Val
245 250 255
Leu Arg Gly Ala Ala Glu Gln Ser Thr His Val Ala Ile Arg Tyr Leu
260 265 270
Gln Ala Gln Glu Ala Ser Ala Ser Asn
275 280
<210> 131
<211> 1530
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1507)
<223> RXN02966
<400> 131
aaatataccc cccagggtat cttgacagat taaagctcga tgttttaggc tctacatata 60
cccccacggg tatcccctca actttgatct aaggtgtcac atg ctt ttt gaa cgc 115
Met Leu Phe Glu Arg
1 5
atc tac gaa gaa ggc ctc gcc caa gcc agc tat ttc att ggc tgc caa 163
Ile Tyr Glu Glu Gly Leu Ala Gln Ala Ser Tyr Phe Ile Gly Cys Gln
10 15 20
cgc gaa ggc aaa gcg att gtt gtt gat gct cgc cga gat atc cag acc 211
Arg Glu Gly Lys Ala Ile Val Val Asp Ala Arg Arg Asp Ile Gln Thr
25 30 35
tat ctg gac ctt gca gca aaa aac aac atg gtc att agc gcc gta acc 259
Tyr Leu Asp Leu Ala Ala Lys Asn Asn Met Val Ile Ser Ala Val Thr
40 45 50
gaa acc cat att cat gcc gat tat ctc tcc ggt act cgc gaa ctt gca 307
Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly Thr Arg Glu Leu Ala
55 60 65
gct gcc acc ggc gcc gag att ttc ctc tct ggc gaa ggc gga gct gat 355
Ala Ala Thr Gly Ala Glu Ile Phe Leu Ser Gly Glu Gly Gly Ala Asp
70 75 80 85
tgg caa tat ggc ttt aca ggc acc acc ttg atg cac aat tcc acc atc 403
Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met His Asn Ser Thr Ile
90 95 100
aag ctg gga aat atc acc atc aca gcc aag cac act ccc gga cac act 451
Lys Leu Gly Asn Ile Thr Ile Thr Ala Lys His Thr Pro Gly His Thr
105 110 115
cca gag cac ctg tca ttt ttg att act gat ggt gcg gtc tca aag gat 499
Pro Glu His Leu Ser Phe Leu Ile Thr Asp Gly Ala Val Ser Lys Asp
120 125 130
ccc ggt ttt atg ctc agc ggt gac ttc gtc ttc gta ggt gac gtg gga 547
Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe Val Gly Asp Val Gly
135 140 145
cgt cca gat tta ctt gat gag gca gct ggc ggc gtg gac acc cgc ttc 595
Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val Asp Thr Arg Phe
150 155 160 165
gcc gga gca cag caa ctc ttc cat agc cta aaa gag cag ttc ctt gca 643
Ala Gly Ala Gln Gln Leu Phe His Ser Leu Lys Glu Gln Phe Leu Ala
170 175 180
ctc ccc gac cac att cag gtt tat cca ggt cat ggt gct ggc agc cct 691
Leu Pro Asp His Ile Gln Val Tyr Pro Gly His Gly Ala Gly Ser Pro
185 190 195
tgt ggc aag gca ttg ggc gcg atc cct agc acc acc gtg gga tat gaa 739
Cys Gly Lys Ala Leu Gly Ala Ile Pro Ser Thr Thr Val Gly Tyr Glu
200 205 210
aag gct aat gcg tgg tgg gct cca tat ctg cgc agt gat gat gaa gcc 787
Lys Ala Asn Ala Trp Trp Ala Pro Tyr Leu Arg Ser Asp Asp Glu Ala
215 220 225
ggc ttt gtg gaa gag ctt ctc gac ggc cag cca gat gcc cac gct tac 835
Gly Phe Val Glu Glu Leu Leu Asp Gly Gln Pro Asp Ala His Ala Tyr
230 235 240 245
ttt gct cgc atg aaa aag cag aac aag cag gga cct gca gta ctt agt 883
Phe Ala Arg Met Lys Lys Gln Asn Lys Gln Gly Pro Ala Val Leu Ser
250 255 260
aca tta tcc ccg ctt gtg aag cta gaa gcc gag gaa gtc gtc gaa aag 931
Thr Leu Ser Pro Leu Val Lys Leu Glu Ala Glu Glu Val Val Glu Lys
265 270 275
ctt ggt tct gaa gca gta ttt gtg gat acc cgc gag caa aac caa gtc 979
Leu Gly Ser Glu Ala Val Phe Val Asp Thr Arg Glu Gln Asn Gln Val
280 285 290
cat ctc gga acc gtt gtt ggg gca ttg aat att ccg cgc ggc gcc aag 1027
His Leu Gly Thr Val Val Gly Ala Leu Asn Ile Pro Arg Gly Ala Lys
295 300 305
gcg tcc aat ttt gcg gcg tgg gtt att gat cct caa aag gat gct cag 1075
Ala Ser Asn Phe Ala Ala Trp Val Ile Asp Pro Gln Lys Asp Ala Gln
310 315 320 325
gac ctt att gtt ttg gct ccg gac gcc aat acc gct gcg gat ttc cgc 1123
Asp Leu Ile Val Leu Ala Pro Asp Ala Asn Thr Ala Ala Asp Phe Arg
330 335 340
gac gct ttg ctg cgg gtt ggc atc gac act gtg cgt tat ttc acc aac 1171
Asp Ala Leu Leu Arg Val Gly Ile Asp Thr Val Arg Tyr Phe Thr Asn
345 350 355
agt atc gat gga ttg cct acc ttt gtg cca gaa ctc atc tcc ccc gct 1219
Ser Ile Asp Gly Leu Pro Thr Phe Val Pro Glu Leu Ile Ser Pro Ala
360 365 370
gag cta gct gag acc aac tat gac gca ctg att gat atc cgt gca aag 1267
Glu Leu Ala Glu Thr Asn Tyr Asp Ala Leu Ile Asp Ile Arg Ala Lys
375 380 385
tcc gaa ttt gcc gct ggc agc att ccc ggc gcg cag cag ctt tct gga 1315
Ser Glu Phe Ala Ala Gly Ser Ile Pro Gly Ala Gln Gln Leu Ser Gly
390 395 400 405
ggt tcg gcc atg tgg cgc ctc aat gag ctg cct gcg ggt ggc act ttg 1363
Gly Ser Ala Met Trp Arg Leu Asn Glu Leu Pro Ala Gly Gly Thr Leu
410 415 420
gta acc ttc tgc caa tca gga gcg cga aat acc gtg gta gcc aat gct 1411
Val Thr Phe Cys Gln Ser Gly Ala Arg Asn Thr Val Val Ala Asn Ala
425 430 435
ttg cga cgc gcc gga ttc acc gtt atc gag ctc gag ggc agc tac gcc 1459
Leu Arg Arg Ala Gly Phe Thr Val Ile Glu Leu Glu Gly Ser Tyr Ala
440 445 450
gcg tgg gaa aaa tca gct gcc aat cct aaa aac ttg cag act gcc gtc 1507
Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn Leu Gln Thr Ala Val
455 460 465
tagttttaga tccggcgctg tat 1530
<210> 132
<211> 469
<212> PRT
<213> Corynebacterium glutamicum
<400> 132
Met Leu Phe Glu Arg Ile Tyr Glu Glu Gly Leu Ala Gln Ala Ser Tyr
1 5 10 15
Phe Ile Gly Cys Gln Arg Glu Gly Lys Ala Ile Val Val Asp Ala Arg
20 25 30
Arg Asp Ile Gln Thr Tyr Leu Asp Leu Ala Ala Lys Asn Asn Met Val
35 40 45
Ile Ser Ala Val Thr Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly
50 55 60
Thr Arg Glu Leu Ala Ala Ala Thr Gly Ala Glu Ile Phe Leu Ser Gly
65 70 75 80
Glu Gly Gly Ala Asp Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met
85 90 95
His Asn Ser Thr Ile Lys Leu Gly Asn Ile Thr Ile Thr Ala Lys His
100 105 110
Thr Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Ile Thr Asp Gly
115 120 125
Ala Val Ser Lys Asp Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe
130 135 140
Val Gly Asp Val Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly
145 150 155 160
Val Asp Thr Arg Phe Ala Gly Ala Gln Gln Leu Phe His Ser Leu Lys
165 170 175
Glu Gln Phe Leu Ala Leu Pro Asp His Ile Gln Val Tyr Pro Gly His
180 185 190
Gly Ala Gly Ser Pro Cys Gly Lys Ala Leu Gly Ala Ile Pro Ser Thr
195 200 205
Thr Val Gly Tyr Glu Lys Ala Asn Ala Trp Trp Ala Pro Tyr Leu Arg
210 215 220
Ser Asp Asp Glu Ala Gly Phe Val Glu Glu Leu Leu Asp Gly Gln Pro
225 230 235 240
Asp Ala His Ala Tyr Phe Ala Arg Met Lys Lys Gln Asn Lys Gln Gly
245 250 255
Pro Ala Val Leu Ser Thr Leu Ser Pro Leu Val Lys Leu Glu Ala Glu
260 265 270
Glu Val Val Glu Lys Leu Gly Ser Glu Ala Val Phe Val Asp Thr Arg
275 280 285
Glu Gln Asn Gln Val His Leu Gly Thr Val Val Gly Ala Leu Asn Ile
290 295 300
Pro Arg Gly Ala Lys Ala Ser Asn Phe Ala Ala Trp Val Ile Asp Pro
305 310 315 320
Gln Lys Asp Ala Gln Asp Leu Ile Val Leu Ala Pro Asp Ala Asn Thr
325 330 335
Ala Ala Asp Phe Arg Asp Ala Leu Leu Arg Val Gly Ile Asp Thr Val
340 345 350
Arg Tyr Phe Thr Asn Ser Ile Asp Gly Leu Pro Thr Phe Val Pro Glu
355 360 365
Leu Ile Ser Pro Ala Glu Leu Ala Glu Thr Asn Tyr Asp Ala Leu Ile
370 375 380
Asp Ile Arg Ala Lys Ser Glu Phe Ala Ala Gly Ser Ile Pro Gly Ala
385 390 395 400
Gln Gln Leu Ser Gly Gly Ser Ala Met Trp Arg Leu Asn Glu Leu Pro
405 410 415
Ala Gly Gly Thr Leu Val Thr Phe Cys Gln Ser Gly Ala Arg Asn Thr
420 425 430
Val Val Ala Asn Ala Leu Arg Arg Ala Gly Phe Thr Val Ile Glu Leu
435 440 445
Glu Gly Ser Tyr Ala Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn
450 455 460
Leu Gln Thr Ala Val
465
<210> 133
<211> 1530
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1507)
<223> FRXA01833
<400> 133
aaatataccc cccagggtat cttgacagat taaagctcga tgttttaggc tctacatata 60
cccccacggg tatcccctca actttgatct aaggtgtcac atg ctt ttt gaa cgc 115
Met Leu Phe Glu Arg
1 5
atc tac gaa gaa ggc ctc gcc caa gcc agc tat ttc att ggc tgc caa 163
Ile Tyr Glu Glu Gly Leu Ala Gln Ala Ser Tyr Phe Ile Gly Cys Gln
10 15 20
cgc gaa ggc aaa gcg att gtt gtt gat gct cgc cga gat atc cag acc 211
Arg Glu Gly Lys Ala Ile Val Val Asp Ala Arg Arg Asp Ile Gln Thr
25 30 35
tat ctg gac ctt gca gca aaa aac aac atg gtc att agc gcc gta acc 259
Tyr Leu Asp Leu Ala Ala Lys Asn Asn Met Val Ile Ser Ala Val Thr
40 45 50
gaa acc cat att cat gcc gat tat ctc tcc ggt act cgc gaa ctt gca 307
Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly Thr Arg Glu Leu Ala
55 60 65
gct gcc acc ggc gcc gag att ttc ctc tct ggc gaa ggc gga gct gat 355
Ala Ala Thr Gly Ala Glu Ile Phe Leu Ser Gly Glu Gly Gly Ala Asp
70 75 80 85
tgg caa tat ggc ttt aca ggc acc acc ttg atg cac aat tcc acc atc 403
Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met His Asn Ser Thr Ile
90 95 100
aag ctg gaa aat atc acc atc aca gcc aag cac act ccc gga cac act 451
Lys Leu Glu Asn Ile Thr Ile Thr Ala Lys His Thr Pro Gly His Thr
105 110 115
cca gag cac ctg tca ttt ttg att act gat ggt gcg gtc tca aag gat 499
Pro Glu His Leu Ser Phe Leu Ile Thr Asp Gly Ala Val Ser Lys Asp
120 125 130
ccc ggt ttt atg ctc agc ggt gac ttc gtc ttc gta ggt gac gtg gga 547
Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe Val Gly Asp Val Gly
135 140 145
cgt cca gat tta ctt gat gag gca gct ggc ggc gtg gac acc cgc ttc 595
Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val Asp Thr Arg Phe
150 155 160 165
gcc gga gca cag caa ctc ttc cat agc cta aaa gag cag ttc ctt gca 643
Ala Gly Ala Gln Gln Leu Phe His Ser Leu Lys Glu Gln Phe Leu Ala
170 175 180
ctc ccc gac cac att cag gtt tat cca ggt cat ggt gct ggc agc cct 691
Leu Pro Asp His Ile Gln Val Tyr Pro Gly His Gly Ala Gly Ser Pro
185 190 195
tgt ggc aag gca ttg ggc gcg atc cct agc acc acc gtg gga tat gaa 739
Cys Gly Lys Ala Leu Gly Ala Ile Pro Ser Thr Thr Val Gly Tyr Glu
200 205 210
aag gct aat gcg tgg tgg gct cca tat ctg cgc agt gat gat gaa gcc 787
Lys Ala Asn Ala Trp Trp Ala Pro Tyr Leu Arg Ser Asp Asp Glu Ala
215 220 225
ggc ttt gtg gaa gag ctt ctc gac ggc cag cca gat gcc cac gct tac 835
Gly Phe Val Glu Glu Leu Leu Asp Gly Gln Pro Asp Ala His Ala Tyr
230 235 240 245
ttt gct cgc atg aaa aag cag aac aag cag gga cct gca gta ctt agt 883
Phe Ala Arg Met Lys Lys Gln Asn Lys Gln Gly Pro Ala Val Leu Ser
250 255 260
aca tta tcc ccg ctt gtg aag cta gaa gcc gag gaa gtc gtc gaa aag 931
Thr Leu Ser Pro Leu Val Lys Leu Glu Ala Glu Glu Val Val Glu Lys
265 270 275
ctt ggt tct gaa gca gta ttt gtg gat acc cgc gag caa aac caa gtc 979
Leu Gly Ser Glu Ala Val Phe Val Asp Thr Arg Glu Gln Asn Gln Val
280 285 290
cat ctc gga acc gtt gtt ggg gca ttg aat att ccg cgc ggc gcc aag 1027
His Leu Gly Thr Val Val Gly Ala Leu Asn Ile Pro Arg Gly Ala Lys
295 300 305
gcg tcc aat ttt gcg gcg tgg gtt att gat cct caa aag gat gct cag 1075
Ala Ser Asn Phe Ala Ala Trp Val Ile Asp Pro Gln Lys Asp Ala Gln
310 315 320 325
gac ctt att gtt ttg gct ccg gac gcc aat acc gct gcg gat ttc cgc 1123
Asp Leu Ile Val Leu Ala Pro Asp Ala Asn Thr Ala Ala Asp Phe Arg
330 335 340
gac gct ttg ctg cgg gtt ggc atc gac act gtg cgt tat ttc acc aac 1171
Asp Ala Leu Leu Arg Val Gly Ile Asp Thr Val Arg Tyr Phe Thr Asn
345 350 355
agt atc gat gga ttg cct acc ttt gtg cca gaa ctc atc tcc ccc gct 1219
Ser Ile Asp Gly Leu Pro Thr Phe Val Pro Glu Leu Ile Ser Pro Ala
360 365 370
gag cta gct gag acc aac tat gac gca ctg att gat atc cgt gca aag 1267
Glu Leu Ala Glu Thr Asn Tyr Asp Ala Leu Ile Asp Ile Arg Ala Lys
375 380 385
tcc gaa ttt gcc gct ggc agc att ccc ggc gcg cag cag ctt tct gga 1315
Ser Glu Phe Ala Ala Gly Ser Ile Pro Gly Ala Gln Gln Leu Ser Gly
390 395 400 405
ggt tcg gcc atg tgg cgc ctc aat gag ctg cct gcg ggt ggc act ttg 1363
Gly Ser Ala Met Trp Arg Leu Asn Glu Leu Pro Ala Gly Gly Thr Leu
410 415 420
gta acc ttc tgc caa tca gga gcg cga aat acc gtg gta gcc aat gct 1411
Val Thr Phe Cys Gln Ser Gly Ala Arg Asn Thr Val Val Ala Asn Ala
425 430 435
ttg cga cgc gcc gga ttc acc gtt atc gag ctc gag ggc agc tac gcc 1459
Leu Arg Arg Ala Gly Phe Thr Val Ile Glu Leu Glu Gly Ser Tyr Ala
440 445 450
gcg tgg gaa aaa tca gct gcc aat cct aaa aac ttg cag act gcc gtc 1507
Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn Leu Gln Thr Ala Val
455 460 465
tagttttaga tccggcgctg tat 1530
<210> 134
<211> 469
<212> PRT
<213> Corynebacterium glutamicum
<400> 134
Met Leu Phe Glu Arg Ile Tyr Glu Glu Gly Leu Ala Gln Ala Ser Tyr
1 5 10 15
Phe Ile Gly Cys Gln Arg Glu Gly Lys Ala Ile Val Val Asp Ala Arg
20 25 30
Arg Asp Ile Gln Thr Tyr Leu Asp Leu Ala Ala Lys Asn Asn Met Val
35 40 45
Ile Ser Ala Val Thr Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly
50 55 60
Thr Arg Glu Leu Ala Ala Ala Thr Gly Ala Glu Ile Phe Leu Ser Gly
65 70 75 80
Glu Gly Gly Ala Asp Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met
85 90 95
His Asn Ser Thr Ile Lys Leu Glu Asn Ile Thr Ile Thr Ala Lys His
100 105 110
Thr Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Ile Thr Asp Gly
115 120 125
Ala Val Ser Lys Asp Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe
130 135 140
Val Gly Asp Val Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly
145 150 155 160
Val Asp Thr Arg Phe Ala Gly Ala Gln Gln Leu Phe His Ser Leu Lys
165 170 175
Glu Gln Phe Leu Ala Leu Pro Asp His Ile Gln Val Tyr Pro Gly His
180 185 190
Gly Ala Gly Ser Pro Cys Gly Lys Ala Leu Gly Ala Ile Pro Ser Thr
195 200 205
Thr Val Gly Tyr Glu Lys Ala Asn Ala Trp Trp Ala Pro Tyr Leu Arg
210 215 220
Ser Asp Asp Glu Ala Gly Phe Val Glu Glu Leu Leu Asp Gly Gln Pro
225 230 235 240
Asp Ala His Ala Tyr Phe Ala Arg Met Lys Lys Gln Asn Lys Gln Gly
245 250 255
Pro Ala Val Leu Ser Thr Leu Ser Pro Leu Val Lys Leu Glu Ala Glu
260 265 270
Glu Val Val Glu Lys Leu Gly Ser Glu Ala Val Phe Val Asp Thr Arg
275 280 285
Glu Gln Asn Gln Val His Leu Gly Thr Val Val Gly Ala Leu Asn Ile
290 295 300
Pro Arg Gly Ala Lys Ala Ser Asn Phe Ala Ala Trp Val Ile Asp Pro
305 310 315 320
Gln Lys Asp Ala Gln Asp Leu Ile Val Leu Ala Pro Asp Ala Asn Thr
325 330 335
Ala Ala Asp Phe Arg Asp Ala Leu Leu Arg Val Gly Ile Asp Thr Val
340 345 350
Arg Tyr Phe Thr Asn Ser Ile Asp Gly Leu Pro Thr Phe Val Pro Glu
355 360 365
Leu Ile Ser Pro Ala Glu Leu Ala Glu Thr Asn Tyr Asp Ala Leu Ile
370 375 380
Asp Ile Arg Ala Lys Ser Glu Phe Ala Ala Gly Ser Ile Pro Gly Ala
385 390 395 400
Gln Gln Leu Ser Gly Gly Ser Ala Met Trp Arg Leu Asn Glu Leu Pro
405 410 415
Ala Gly Gly Thr Leu Val Thr Phe Cys Gln Ser Gly Ala Arg Asn Thr
420 425 430
Val Val Ala Asn Ala Leu Arg Arg Ala Gly Phe Thr Val Ile Glu Leu
435 440 445
Glu Gly Ser Tyr Ala Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn
450 455 460
Leu Gln Thr Ala Val
465
<210> 135
<211> 675
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(652)
<223> RXA01853
<400> 135
gaatgtccaa cgtcaaaaaa attcttttct atcctaaccg tatcttcaca ccttgaggga 60
atgatggggg agcgccgctt acgcactaca ctgtttattc atg gag atc ctc gga 115
Met Glu Ile Leu Gly
1 5
ttc gcg gct ggt ccg tat aaa aca aat tgc tat gtg gtg cgc ggg gag 163
Phe Ala Ala Gly Pro Tyr Lys Thr Asn Cys Tyr Val Val Arg Gly Glu
10 15 20
aat gag gtc gcg atc att gat cct ggc atg cat gcc cac gat gat ttg 211
Asn Glu Val Ala Ile Ile Asp Pro Gly Met His Ala His Asp Asp Leu
25 30 35
gtg gaa tac atc acc acg aat aat ttg agc gtg gac aag att gtg ctc 259
Val Glu Tyr Ile Thr Thr Asn Asn Leu Ser Val Asp Lys Ile Val Leu
40 45 50
acc cac gga cac att gat cac acc cgt gat gct ggt gtt gtg gca aag 307
Thr His Gly His Ile Asp His Thr Arg Asp Ala Gly Val Val Ala Lys
55 60 65
cgt ttc aat gcg ccg gtc tat atc cat cct gat gat gcg ttt ttc ctt 355
Arg Phe Asn Ala Pro Val Tyr Ile His Pro Asp Asp Ala Phe Phe Leu
70 75 80 85
gag gtc tac aag gga tct gga aca aag acg gcc atg ctt ttc gac gcc 403
Glu Val Tyr Lys Gly Ser Gly Thr Lys Thr Ala Met Leu Phe Asp Ala
90 95 100
gac aac atg gtg tcc cct gat cct gag tca ctg cgt gat ctg gtt gat 451
Asp Asn Met Val Ser Pro Asp Pro Glu Ser Leu Arg Asp Leu Val Asp
105 110 115
ggt gag aca atc act ttg gct ggc gaa gaa ttc acg ttg aag cat gca 499
Gly Glu Thr Ile Thr Leu Ala Gly Glu Glu Phe Thr Leu Lys His Ala
120 125 130
cca ggg cat tca cct ggt tgt acg ctg atc gtc ggc aag gaa tac tgc 547
Pro Gly His Ser Pro Gly Cys Thr Leu Ile Val Gly Lys Glu Tyr Cys
135 140 145
ttt agc ggt gat gtg ttg ttc aag ggc tct att ggt cgc act gat ttt 595
Phe Ser Gly Asp Val Leu Phe Lys Gly Ser Ile Gly Arg Thr Asp Phe
150 155 160 165
gag tgg tct gat gca gat gcc atg aat gag tca cta cgc acg gca gtg 643
Glu Trp Ser Asp Ala Asp Ala Met Asn Glu Ser Leu Arg Thr Ala Val
170 175 180
ctc cca ctt tgatgatgca ttgcagattc ttc 675
Leu Pro Leu
<210> 136
<211> 184
<212> PRT
<213> Corynebacterium glutamicum
<400> 136
Met Glu Ile Leu Gly Phe Ala Ala Gly Pro Tyr Lys Thr Asn Cys Tyr
1 5 10 15
Val Val Arg Gly Glu Asn Glu Val Ala Ile Ile Asp Pro Gly Met His
20 25 30
Ala His Asp Asp Leu Val Glu Tyr Ile Thr Thr Asn Asn Leu Ser Val
35 40 45
Asp Lys Ile Val Leu Thr His Gly His Ile Asp His Thr Arg Asp Ala
50 55 60
Gly Val Val Ala Lys Arg Phe Asn Ala Pro Val Tyr Ile His Pro Asp
65 70 75 80
Asp Ala Phe Phe Leu Glu Val Tyr Lys Gly Ser Gly Thr Lys Thr Ala
85 90 95
Met Leu Phe Asp Ala Asp Asn Met Val Ser Pro Asp Pro Glu Ser Leu
100 105 110
Arg Asp Leu Val Asp Gly Glu Thr Ile Thr Leu Ala Gly Glu Glu Phe
115 120 125
Thr Leu Lys His Ala Pro Gly His Ser Pro Gly Cys Thr Leu Ile Val
130 135 140
Gly Lys Glu Tyr Cys Phe Ser Gly Asp Val Leu Phe Lys Gly Ser Ile
145 150 155 160
Gly Arg Thr Asp Phe Glu Trp Ser Asp Ala Asp Ala Met Asn Glu Ser
165 170 175
Leu Arg Thr Ala Val Leu Pro Leu
180
<210> 137
<211> 723
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(700)
<223> RXN02424
<400> 137
agccaatgct caactgccct tcaaaatcga tttttgtcgc ttcaaaaaat acaccttcga 60
acatagcatc gaacaaggtg tttccgctag tctgaaccac atg act aac gag ctc 115
Met Thr Asn Glu Leu
1 5
act ctt cac cat att tcc gtg tcc caa atg gac aac aat tgc tac ctt 163
Thr Leu His His Ile Ser Val Ser Gln Met Asp Asn Asn Cys Tyr Leu
10 15 20
ttg gcc gca aat ggc aac ggt tta ctc att gat gct gca gat gac gca 211
Leu Ala Ala Asn Gly Asn Gly Leu Leu Ile Asp Ala Ala Asp Asp Ala
25 30 35
gct gca cta ctt aaa tta gcc gaa gat gcc ggt gtg acc atc acc aaa 259
Ala Ala Leu Leu Lys Leu Ala Glu Asp Ala Gly Val Thr Ile Thr Lys
40 45 50
gtg ttg acc acc cac cgc cac gca gac cac gtc cgt gca ttg ccg gag 307
Val Leu Thr Thr His Arg His Ala Asp His Val Arg Ala Leu Pro Glu
55 60 65
gtt ctc cag aag acc gga gca act cac tac gcg cct ttc ctt gag gtg 355
Val Leu Gln Lys Thr Gly Ala Thr His Tyr Ala Pro Phe Leu Glu Val
70 75 80 85
cca gct ttg ccc tcc gct gtt gat gtg gaa ctg cat cat ggt gat tca 403
Pro Ala Leu Pro Ser Ala Val Asp Val Glu Leu His His Gly Asp Ser
90 95 100
att gaa ttt gag ggt cat gta ttc cct atc agc att ctg cgc ggc cac 451
Ile Glu Phe Glu Gly His Val Phe Pro Ile Ser Ile Leu Arg Gly His
105 110 115
acc cca ggc ggt gca gta ctc acc gct gag atc gac ggt aaa act cac 499
Thr Pro Gly Gly Ala Val Leu Thr Ala Glu Ile Asp Gly Lys Thr His
120 125 130
ctt ttc gtg ggt gac agc ctc ttc ccc ggc ggt ttg ggc aaa acc agc 547
Leu Phe Val Gly Asp Ser Leu Phe Pro Gly Gly Leu Gly Lys Thr Ser
135 140 145
agc gaa ggc gac ttc gtc cga ctg ttc aac gat gtc aaa gag cgc atc 595
Ser Glu Gly Asp Phe Val Arg Leu Phe Asn Asp Val Lys Glu Arg Ile
150 155 160 165
ttt gac acc tac gac gat gac agc atc gtg tgg cca ggt cac ggc aag 643
Phe Asp Thr Tyr Asp Asp Asp Ser Ile Val Trp Pro Gly His Gly Lys
170 175 180
gaa acc acc ctt gga gcc gag cgt cca cag ctg gaa atc tgg tgg gag 691
Glu Thr Thr Leu Gly Ala Glu Arg Pro Gln Leu Glu Ile Trp Trp Glu
185 190 195
cgt cgc tgg taagcgcttt tctcaaccag gca 723
Arg Arg Trp
200
<210> 138
<211> 200
<212> PRT
<213> Corynebacterium glutamicum
<400> 138
Met Thr Asn Glu Leu Thr Leu His His Ile Ser Val Ser Gln Met Asp
1 5 10 15
Asn Asn Cys Tyr Leu Leu Ala Ala Asn Gly Asn Gly Leu Leu Ile Asp
20 25 30
Ala Ala Asp Asp Ala Ala Ala Leu Leu Lys Leu Ala Glu Asp Ala Gly
35 40 45
Val Thr Ile Thr Lys Val Leu Thr Thr His Arg His Ala Asp His Val
50 55 60
Arg Ala Leu Pro Glu Val Leu Gln Lys Thr Gly Ala Thr His Tyr Ala
65 70 75 80
Pro Phe Leu Glu Val Pro Ala Leu Pro Ser Ala Val Asp Val Glu Leu
85 90 95
His His Gly Asp Ser Ile Glu Phe Glu Gly His Val Phe Pro Ile Ser
100 105 110
Ile Leu Arg Gly His Thr Pro Gly Gly Ala Val Leu Thr Ala Glu Ile
115 120 125
Asp Gly Lys Thr His Leu Phe Val Gly Asp Ser Leu Phe Pro Gly Gly
130 135 140
Leu Gly Lys Thr Ser Ser Glu Gly Asp Phe Val Arg Leu Phe Asn Asp
145 150 155 160
Val Lys Glu Arg Ile Phe Asp Thr Tyr Asp Asp Asp Ser Ile Val Trp
165 170 175
Pro Gly His Gly Lys Glu Thr Thr Leu Gly Ala Glu Arg Pro Gln Leu
180 185 190
Glu Ile Trp Trp Glu Arg Arg Trp
195 200
<210> 139
<211> 404
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(381)
<223> FRXA02424
<400> 139
acc gga gca act cac tac gcg cct ttc ctt gag gtg cca gct ttg ccc 48
Thr Gly Ala Thr His Tyr Ala Pro Phe Leu Glu Val Pro Ala Leu Pro
1 5 10 15
tcc gct gtt gat gtg gaa ctg cat cat ggt gat tca att gaa ttt gag 96
Ser Ala Val Asp Val Glu Leu His His Gly Asp Ser Ile Glu Phe Glu
20 25 30
ggt cat gta ttc cct atc agc att ctg cgc ggc cac acc cca ggc ggt 144
Gly His Val Phe Pro Ile Ser Ile Leu Arg Gly His Thr Pro Gly Gly
35 40 45
gca gta ctc acc gct gag atc gac ggt aaa act cac ctt ttc gtg ggt 192
Ala Val Leu Thr Ala Glu Ile Asp Gly Lys Thr His Leu Phe Val Gly
50 55 60
gac agc ctc ttc ccc ggc ggt ttg ggc aaa acc agc agc gaa ggc gac 240
Asp Ser Leu Phe Pro Gly Gly Leu Gly Lys Thr Ser Ser Glu Gly Asp
65 70 75 80
ttc gtc cga ctg ttc aac gat gtc aaa gag cgc atc ttt gac acc tac 288
Phe Val Arg Leu Phe Asn Asp Val Lys Glu Arg Ile Phe Asp Thr Tyr
85 90 95
gac gat gac agc atc gtg tgg cca ggt cac ggc aag gaa acc acc ctt 336
Asp Asp Asp Ser Ile Val Trp Pro Gly His Gly Lys Glu Thr Thr Leu
100 105 110
gga gcc gag cgt cca cag ctg gaa atc tgg tgg gag cgt cgc tgg 381
Gly Ala Glu Arg Pro Gln Leu Glu Ile Trp Trp Glu Arg Arg Trp
115 120 125
taagcgcttt tctcaaccag gca 404
<210> 140
<211> 127
<212> PRT
<213> Corynebacterium glutamicum
<400> 140
Thr Gly Ala Thr His Tyr Ala Pro Phe Leu Glu Val Pro Ala Leu Pro
1 5 10 15
Ser Ala Val Asp Val Glu Leu His His Gly Asp Ser Ile Glu Phe Glu
20 25 30
Gly His Val Phe Pro Ile Ser Ile Leu Arg Gly His Thr Pro Gly Gly
35 40 45
Ala Val Leu Thr Ala Glu Ile Asp Gly Lys Thr His Leu Phe Val Gly
50 55 60
Asp Ser Leu Phe Pro Gly Gly Leu Gly Lys Thr Ser Ser Glu Gly Asp
65 70 75 80
Phe Val Arg Leu Phe Asn Asp Val Lys Glu Arg Ile Phe Asp Thr Tyr
85 90 95
Asp Asp Asp Ser Ile Val Trp Pro Gly His Gly Lys Glu Thr Thr Leu
100 105 110
Gly Ala Glu Arg Pro Gln Leu Glu Ile Trp Trp Glu Arg Arg Trp
115 120 125
<210> 141
<211> 882
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(859)
<223> RXN00419
<400> 141
gctggttgaa gactcgaaat gagatcgacc caaccggagt ctttgcatct gacatgtccc 60
gccgacttga gctttcttaa gaaagggctt gaactaaaca atg ctt aac gca gtg 115
Met Leu Asn Ala Val
1 5
ggc aaa gcc caa aac att ctc ctt ctt ggt gga acc tct gag atc ggt 163
Gly Lys Ala Gln Asn Ile Leu Leu Leu Gly Gly Thr Ser Glu Ile Gly
10 15 20
att tcc att gtc tcc cgc ttc ctc aag cag ggt cca tcc cat gtg acc 211
Ile Ser Ile Val Ser Arg Phe Leu Lys Gln Gly Pro Ser His Val Thr
25 30 35
ttg gca gcg cgt aaa gat tcc cca cgc gtg gac gca gca gtc gca gag 259
Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp Ala Ala Val Ala Glu
40 45 50
atc aaa gca gct ggc gct gct tcc gtt gct gtt gtt gat ttc gat gcg 307
Ile Lys Ala Ala Gly Ala Ala Ser Val Ala Val Val Asp Phe Asp Ala
55 60 65
ctc gac acc gaa tcc cac cct gca gcc atc gac gca gcc ttt gaa aac 355
Leu Asp Thr Glu Ser His Pro Ala Ala Ile Asp Ala Ala Phe Glu Asn
70 75 80 85
ggc gac gtt gac gta gca atc gtg gct ttc ggc atc ctc ggc gac aac 403
Gly Asp Val Asp Val Ala Ile Val Ala Phe Gly Ile Leu Gly Asp Asn
90 95 100
gaa gca cag tgg cgc gac caa gca cta gca gtg gaa gca acc acc gtg 451
Glu Ala Gln Trp Arg Asp Gln Ala Leu Ala Val Glu Ala Thr Thr Val
105 110 115
aac tac acc gcc ggc gtt tcc gta ggt gta ctg ctg ggc cag aaa ttt 499
Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu Leu Gly Gln Lys Phe
120 125 130
gag cag cag ggc cac ggc acc atc gtg gca ttg tcc tct gtg gca ggc 547
Glu Gln Gln Gly His Gly Thr Ile Val Ala Leu Ser Ser Val Ala Gly
135 140 145
cag cga gtc cgc cgc tcc aac ttt gtc tac ggc tcc gcc aag gca ggt 595
Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly Ser Ala Lys Ala Gly
150 155 160 165
ttc gac ggt ttc tac acc cag ctc ggc gaa gcc ctg cgt gga tcc ggt 643
Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Ala Leu Arg Gly Ser Gly
170 175 180
gcc aac gta ttg gtg gtt cgc cca ggc cag gta cgc acc aag atg tcc 691
Ala Asn Val Leu Val Val Arg Pro Gly Gln Val Arg Thr Lys Met Ser
185 190 195
gca gat ggt ggc gaa gcc cca ctg acc gtc aac cgc gaa gac gtg gca 739
Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn Arg Glu Asp Val Ala
200 205 210
gat gct gtt tat gat gca gtg gtg aac aag aag gac atc atc ttt gtc 787
Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys Asp Ile Ile Phe Val
215 220 225
cac cca ctg ttc cag tac gtc tct ttt gcg ttc caa ttc att ccg cga 835
His Pro Leu Phe Gln Tyr Val Ser Phe Ala Phe Gln Phe Ile Pro Arg
230 235 240 245
gca atc ttc cgc aag ctg ccg ttc taacggaagt tacggaagtt acg 882
Ala Ile Phe Arg Lys Leu Pro Phe
250
<210> 142
<211> 253
<212> PRT
<213> Corynebacterium glutamicum
<400> 142
Met Leu Asn Ala Val Gly Lys Ala Gln Asn Ile Leu Leu Leu Gly Gly
1 5 10 15
Thr Ser Glu Ile Gly Ile Ser Ile Val Ser Arg Phe Leu Lys Gln Gly
20 25 30
Pro Ser His Val Thr Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp
35 40 45
Ala Ala Val Ala Glu Ile Lys Ala Ala Gly Ala Ala Ser Val Ala Val
50 55 60
Val Asp Phe Asp Ala Leu Asp Thr Glu Ser His Pro Ala Ala Ile Asp
65 70 75 80
Ala Ala Phe Glu Asn Gly Asp Val Asp Val Ala Ile Val Ala Phe Gly
85 90 95
Ile Leu Gly Asp Asn Glu Ala Gln Trp Arg Asp Gln Ala Leu Ala Val
100 105 110
Glu Ala Thr Thr Val Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu
115 120 125
Leu Gly Gln Lys Phe Glu Gln Gln Gly His Gly Thr Ile Val Ala Leu
130 135 140
Ser Ser Val Ala Gly Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly
145 150 155 160
Ser Ala Lys Ala Gly Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Ala
165 170 175
Leu Arg Gly Ser Gly Ala Asn Val Leu Val Val Arg Pro Gly Gln Val
180 185 190
Arg Thr Lys Met Ser Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn
195 200 205
Arg Glu Asp Val Ala Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys
210 215 220
Asp Ile Ile Phe Val His Pro Leu Phe Gln Tyr Val Ser Phe Ala Phe
225 230 235 240
Gln Phe Ile Pro Arg Ala Ile Phe Arg Lys Leu Pro Phe
245 250
<210> 143
<211> 485
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(462)
<223> FRXA00419
<400> 143
gac aac gaa gca cag tgg cgc gac caa gca cta gca gtg gaa gca acc 48
Asp Asn Glu Ala Gln Trp Arg Asp Gln Ala Leu Ala Val Glu Ala Thr
1 5 10 15
acc gtg aac tac acc gcc ggc gtt tcc gta ggt gta ctg ctg ggc cag 96
Thr Val Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu Leu Gly Gln
20 25 30
aaa ttt gag cag cag ggc cac ggc acc atc gtg gca ttg tcc tct gtg 144
Lys Phe Glu Gln Gln Gly His Gly Thr Ile Val Ala Leu Ser Ser Val
35 40 45
gca ggc cag cga gtc cgc cgc tcc aac ttt gtc tac ggc tcc gcc aag 192
Ala Gly Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly Ser Ala Lys
50 55 60
gca ggt ttc gac ggt ttc tac acc cag ctc ggc gaa gcc ctg cgt gga 240
Ala Gly Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Ala Leu Arg Gly
65 70 75 80
tcc ggt gcc aac gta ttg gtg gtt cgc cca ggc cag gta cgc acc aag 288
Ser Gly Ala Asn Val Leu Val Val Arg Pro Gly Gln Val Arg Thr Lys
85 90 95
atg tcc gca gat ggt ggc gaa gcc cca ctg acc gtc aac cgc gaa gac 336
Met Ser Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn Arg Glu Asp
100 105 110
gtg gca gat gct gtt tat gat gca gtg gtg aac aag aag gac atc atc 384
Val Ala Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys Asp Ile Ile
115 120 125
ttt gtc cac cca ctg ttc cag tac gtc tct ttt gcg ttc caa ttc att 432
Phe Val His Pro Leu Phe Gln Tyr Val Ser Phe Ala Phe Gln Phe Ile
130 135 140
ccg cga gca atc ttc cgc aag ctg ccg ttc taacggaagt tacggaagtt 482
Pro Arg Ala Ile Phe Arg Lys Leu Pro Phe
145 150
acg 485
<210> 144
<211> 154
<212> PRT
<213> Corynebacterium glutamicum
<400> 144
Asp Asn Glu Ala Gln Trp Arg Asp Gln Ala Leu Ala Val Glu Ala Thr
1 5 10 15
Thr Val Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu Leu Gly Gln
20 25 30
Lys Phe Glu Gln Gln Gly His Gly Thr Ile Val Ala Leu Ser Ser Val
35 40 45
Ala Gly Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly Ser Ala Lys
50 55 60
Ala Gly Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Ala Leu Arg Gly
65 70 75 80
Ser Gly Ala Asn Val Leu Val Val Arg Pro Gly Gln Val Arg Thr Lys
85 90 95
Met Ser Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn Arg Glu Asp
100 105 110
Val Ala Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys Asp Ile Ile
115 120 125
Phe Val His Pro Leu Phe Gln Tyr Val Ser Phe Ala Phe Gln Phe Ile
130 135 140
Pro Arg Ala Ile Phe Arg Lys Leu Pro Phe
145 150
<210> 145
<211> 259
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(259)
<223> FRXA00421
<400> 145
gctggttgaa gactcgaaat gagatcgacc caaccggagt ctttgcatct gacatgtccc 60
gccgacttga gctttcttaa gaaagggctt gaactaaaca atg ctt aac gca gtg 115
Met Leu Asn Ala Val
1 5
ggc aaa gcc caa aac att ctc ctt ctt ggt gga acc tct gag atc ggt 163
Gly Lys Ala Gln Asn Ile Leu Leu Leu Gly Gly Thr Ser Glu Ile Gly
10 15 20
att tcc att gtc tcc cgc ttc ctc aag cag ggt cca tcc cat gtg acc 211
Ile Ser Ile Val Ser Arg Phe Leu Lys Gln Gly Pro Ser His Val Thr
25 30 35
ttg gca gcg cgt aaa gat tcc cca cgc gtg gac gca gca gtc gca gag 259
Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp Ala Ala Val Ala Glu
40 45 50
<210> 146
<211> 53
<212> PRT
<213> Corynebacterium glutamicum
<400> 146
Met Leu Asn Ala Val Gly Lys Ala Gln Asn Ile Leu Leu Leu Gly Gly
1 5 10 15
Thr Ser Glu Ile Gly Ile Ser Ile Val Ser Arg Phe Leu Lys Gln Gly
20 25 30
Pro Ser His Val Thr Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp
35 40 45
Ala Ala Val Ala Glu
50
<210> 147
<211> 861
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(838)
<223> RXN02923
<400> 147
gcatctacat tgaaggaatc cacggagcgc gcatcgaaga catcgttgtg gtgaatgaag 60
acggttgtga aaccctcaac aaccagccca aggaactgcg ttg agc att ctt ctc 115
Leu Ser Ile Leu Leu
1 5
cta ggc gga acc tct gac att gcc ggt gag att gcc acg ttg acg tgt 163
Leu Gly Gly Thr Ser Asp Ile Ala Gly Glu Ile Ala Thr Leu Thr Cys
10 15 20
cac ggc gaa gac gtt gtt ttg gct gct cgt cga cca gag gct gca cag 211
His Gly Glu Asp Val Val Leu Ala Ala Arg Arg Pro Glu Ala Ala Gln
25 30 35
ggc tta gcg gaa gat ctt cga cag cgc ggt gcc aca tct gtt cat gtt 259
Gly Leu Ala Glu Asp Leu Arg Gln Arg Gly Ala Thr Ser Val His Val
40 45 50
ttg agc ttt gac gcc caa gta cta gac acg cac cga gaa ctt gtg aag 307
Leu Ser Phe Asp Ala Gln Val Leu Asp Thr His Arg Glu Leu Val Lys
55 60 65
aaa aca caa gag cta gct ggc gag att tcc ctt gcc gtg gtt gct ttt 355
Lys Thr Gln Glu Leu Ala Gly Glu Ile Ser Leu Ala Val Val Ala Phe
70 75 80 85
ggc atc ttg gga gac caa gaa cgc gca gaa acc gat gag acc cat gcg 403
Gly Ile Leu Gly Asp Gln Glu Arg Ala Glu Thr Asp Glu Thr His Ala
90 95 100
gta gag atc gcc acc gtg gat tac acc gct cag gtc tcc atg ctc act 451
Val Glu Ile Ala Thr Val Asp Tyr Thr Ala Gln Val Ser Met Leu Thr
105 110 115
gtg ctt gct gat gag ctc cgc gca caa act act cca gca gcg atc gtg 499
Val Leu Ala Asp Glu Leu Arg Ala Gln Thr Thr Pro Ala Ala Ile Val
120 125 130
gcg ttt tcc tcg att gct ggg tgg cgg gcg cgc cgg cct aac tat gtc 547
Ala Phe Ser Ser Ile Ala Gly Trp Arg Ala Arg Arg Pro Asn Tyr Val
135 140 145
tat gga tcc acc aag gct ggt ctc gat gca ttt tgc caa ggg ctt gca 595
Tyr Gly Ser Thr Lys Ala Gly Leu Asp Ala Phe Cys Gln Gly Leu Ala
150 155 160 165
gat agc ctg cat ggg aca cac gtg cga ttg att att gcg cgt cct ggc 643
Asp Ser Leu His Gly Thr His Val Arg Leu Ile Ile Ala Arg Pro Gly
170 175 180
ttt gtt att ggt tct atg acc acg ggg atg aag cct gct ccg atg tcg 691
Phe Val Ile Gly Ser Met Thr Thr Gly Met Lys Pro Ala Pro Met Ser
185 190 195
gtg tat cca cga gat gtt gcc gca gct gtt gtt agt gct tat acc tct 739
Val Tyr Pro Arg Asp Val Ala Ala Ala Val Val Ser Ala Tyr Thr Ser
200 205 210
aag aag agg agc acg acc ttg tgg att ccg gga cgt ctg cgg gtt ctc 787
Lys Lys Arg Ser Thr Thr Leu Trp Ile Pro Gly Arg Leu Arg Val Leu
215 220 225
gcc tgg att atg cgg atg gtt cct cgt ccg gtg tgg cgg aag atg cca 835
Ala Trp Ile Met Arg Met Val Pro Arg Pro Val Trp Arg Lys Met Pro
230 235 240 245
cgc tagatacccg ttcagccctc aca 861
Arg
<210> 148
<211> 246
<212> PRT
<213> Corynebacterium glutamicum
<400> 148
Leu Ser Ile Leu Leu Leu Gly Gly Thr Ser Asp Ile Ala Gly Glu Ile
1 5 10 15
Ala Thr Leu Thr Cys His Gly Glu Asp Val Val Leu Ala Ala Arg Arg
20 25 30
Pro Glu Ala Ala Gln Gly Leu Ala Glu Asp Leu Arg Gln Arg Gly Ala
35 40 45
Thr Ser Val His Val Leu Ser Phe Asp Ala Gln Val Leu Asp Thr His
50 55 60
Arg Glu Leu Val Lys Lys Thr Gln Glu Leu Ala Gly Glu Ile Ser Leu
65 70 75 80
Ala Val Val Ala Phe Gly Ile Leu Gly Asp Gln Glu Arg Ala Glu Thr
85 90 95
Asp Glu Thr His Ala Val Glu Ile Ala Thr Val Asp Tyr Thr Ala Gln
100 105 110
Val Ser Met Leu Thr Val Leu Ala Asp Glu Leu Arg Ala Gln Thr Thr
115 120 125
Pro Ala Ala Ile Val Ala Phe Ser Ser Ile Ala Gly Trp Arg Ala Arg
130 135 140
Arg Pro Asn Tyr Val Tyr Gly Ser Thr Lys Ala Gly Leu Asp Ala Phe
145 150 155 160
Cys Gln Gly Leu Ala Asp Ser Leu His Gly Thr His Val Arg Leu Ile
165 170 175
Ile Ala Arg Pro Gly Phe Val Ile Gly Ser Met Thr Thr Gly Met Lys
180 185 190
Pro Ala Pro Met Ser Val Tyr Pro Arg Asp Val Ala Ala Ala Val Val
195 200 205
Ser Ala Tyr Thr Ser Lys Lys Arg Ser Thr Thr Leu Trp Ile Pro Gly
210 215 220
Arg Leu Arg Val Leu Ala Trp Ile Met Arg Met Val Pro Arg Pro Val
225 230 235 240
Trp Arg Lys Met Pro Arg
245
<210> 149
<211> 1203
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1180)
<223> RXN02922
<400> 149
cccaccgcgg cgcaagctac cgcctaggcg ctcggaactc caccgccact attgatctca 60
gttccatatc cgcccaacta gtttcccagg gagcccactc atg atc tca ccg caa 115
Met Ile Ser Pro Gln
1 5
aca atc atc gac aat ctt gct cca gtc ctc gcg gag atc gca gca acg 163
Thr Ile Ile Asp Asn Leu Ala Pro Val Leu Ala Glu Ile Ala Ala Thr
10 15 20
gct gcg cag cgc gaa cag gat cga gaa ttc agc cgt gat ttg gca aag 211
Ala Ala Gln Arg Glu Gln Asp Arg Glu Phe Ser Arg Asp Leu Ala Lys
25 30 35
cag ctt agt gcc ggt ggg ttc act aaa ctc cgc att cca gtt gaa ttt 259
Gln Leu Ser Ala Gly Gly Phe Thr Lys Leu Arg Ile Pro Val Glu Phe
40 45 50
ggc ggt ttg ggt ttt agc ctt cca gaa gca ttt gag gtg ctg gtg gca 307
Gly Gly Leu Gly Phe Ser Leu Pro Glu Ala Phe Glu Val Leu Val Ala
55 60 65
gcg gcc gct gca gat tca aat atc gcg cag gga ttg cgg cct cac ttc 355
Ala Ala Ala Ala Asp Ser Asn Ile Ala Gln Gly Leu Arg Pro His Phe
70 75 80 85
ttg gca gtg gag agc tta ttg atc gct cct tat tca gag cac cgc acc 403
Leu Ala Val Glu Ser Leu Leu Ile Ala Pro Tyr Ser Glu His Arg Thr
90 95 100
aag tgg ctg cga aaa atc gct gag aaa ggc gtg gtc att ggc aat gcg 451
Lys Trp Leu Arg Lys Ile Ala Glu Lys Gly Val Val Ile Gly Asn Ala
105 110 115
ttg act gaa gtg gga aac aag cca ggt gag ctg aaa acc aag atc cga 499
Leu Thr Glu Val Gly Asn Lys Pro Gly Glu Leu Lys Thr Lys Ile Arg
120 125 130
aag gaa ggc gag tct tac gtt ctc agc gac acc aag ttc tat tcc acg 547
Lys Glu Gly Glu Ser Tyr Val Leu Ser Asp Thr Lys Phe Tyr Ser Thr
135 140 145
ggc agt ctt tac gcc gac tgg att caa gta cat gcg aaa gat gag gaa 595
Gly Ser Leu Tyr Ala Asp Trp Ile Gln Val His Ala Lys Asp Glu Glu
150 155 160 165
gat caa gat gtt ttc gcc ttt gtt gat cgc gac gca tca ggc gtt gtt 643
Asp Gln Asp Val Phe Ala Phe Val Asp Arg Asp Ala Ser Gly Val Val
170 175 180
ttg gtg gat tac tgg gac gaa ttt ggg caa caa cta ttt gcc tcc gga 691
Leu Val Asp Tyr Trp Asp Glu Phe Gly Gln Gln Leu Phe Ala Ser Gly
185 190 195
acc agc ttc ttt gaa aaa gtc gtg gta gat cca ctg gac att gtc acc 739
Thr Ser Phe Phe Glu Lys Val Val Val Asp Pro Leu Asp Ile Val Thr
200 205 210
cgt gat tac acc gca ccc agc gct ttc cag gcg ctg gcg cag tca cat 787
Arg Asp Tyr Thr Ala Pro Ser Ala Phe Gln Ala Leu Ala Gln Ser His
215 220 225
cat ttg tct acg ttg act ggt att tcg cag gca atc acc cgt gac att 835
His Leu Ser Thr Leu Thr Gly Ile Ser Gln Ala Ile Thr Arg Asp Ile
230 235 240 245
gtt acc tat gta caa aac cgc acc cgt att ttc agc cac gga agt ggt 883
Val Thr Tyr Val Gln Asn Arg Thr Arg Ile Phe Ser His Gly Ser Gly
250 255 260
gac ctt cca cgc ttt gat ccg cag gtg caa cag gtg gtg ggt gag gtg 931
Asp Leu Pro Arg Phe Asp Pro Gln Val Gln Gln Val Val Gly Glu Val
265 270 275
aaa gcc aag tcg tat gca gtc gag aaa atc ttt cag ggt ttc gca caa 979
Lys Ala Lys Ser Tyr Ala Val Glu Lys Ile Phe Gln Gly Phe Ala Gln
280 285 290
gaa ctg gat ctt gtc gtc gat aag gca aaa gcc ggc act gct acg gag 1027
Glu Leu Asp Leu Val Val Asp Lys Ala Lys Ala Gly Thr Ala Thr Glu
295 300 305
gtc gat ctg gcc gct gtc gac ctg agc gcc tac caa gcc cag tta gcg 1075
Val Asp Leu Ala Ala Val Asp Leu Ser Ala Tyr Gln Ala Gln Leu Ala
310 315 320 325
gtg gca cct ttg gtg ctg agc cag gcc acc cag gcc ttt gag gtt ggc 1123
Val Ala Pro Leu Val Leu Ser Gln Ala Thr Gln Ala Phe Glu Val Gly
330 335 340
gca gat gcc tta aac ggc ggc cac gtg gct gcc caa tac acg atc gga 1171
Ala Asp Ala Leu Asn Gly Gly His Val Ala Ala Gln Tyr Thr Ile Gly
345 350 355
tcc ttg tca tgagccaaga aattttgagc cat 1203
Ser Leu Ser
360
<210> 150
<211> 360
<212> PRT
<213> Corynebacterium glutamicum
<400> 150
Met Ile Ser Pro Gln Thr Ile Ile Asp Asn Leu Ala Pro Val Leu Ala
1 5 10 15
Glu Ile Ala Ala Thr Ala Ala Gln Arg Glu Gln Asp Arg Glu Phe Ser
20 25 30
Arg Asp Leu Ala Lys Gln Leu Ser Ala Gly Gly Phe Thr Lys Leu Arg
35 40 45
Ile Pro Val Glu Phe Gly Gly Leu Gly Phe Ser Leu Pro Glu Ala Phe
50 55 60
Glu Val Leu Val Ala Ala Ala Ala Ala Asp Ser Asn Ile Ala Gln Gly
65 70 75 80
Leu Arg Pro His Phe Leu Ala Val Glu Ser Leu Leu Ile Ala Pro Tyr
85 90 95
Ser Glu His Arg Thr Lys Trp Leu Arg Lys Ile Ala Glu Lys Gly Val
100 105 110
Val Ile Gly Asn Ala Leu Thr Glu Val Gly Asn Lys Pro Gly Glu Leu
115 120 125
Lys Thr Lys Ile Arg Lys Glu Gly Glu Ser Tyr Val Leu Ser Asp Thr
130 135 140
Lys Phe Tyr Ser Thr Gly Ser Leu Tyr Ala Asp Trp Ile Gln Val His
145 150 155 160
Ala Lys Asp Glu Glu Asp Gln Asp Val Phe Ala Phe Val Asp Arg Asp
165 170 175
Ala Ser Gly Val Val Leu Val Asp Tyr Trp Asp Glu Phe Gly Gln Gln
180 185 190
Leu Phe Ala Ser Gly Thr Ser Phe Phe Glu Lys Val Val Val Asp Pro
195 200 205
Leu Asp Ile Val Thr Arg Asp Tyr Thr Ala Pro Ser Ala Phe Gln Ala
210 215 220
Leu Ala Gln Ser His His Leu Ser Thr Leu Thr Gly Ile Ser Gln Ala
225 230 235 240
Ile Thr Arg Asp Ile Val Thr Tyr Val Gln Asn Arg Thr Arg Ile Phe
245 250 255
Ser His Gly Ser Gly Asp Leu Pro Arg Phe Asp Pro Gln Val Gln Gln
260 265 270
Val Val Gly Glu Val Lys Ala Lys Ser Tyr Ala Val Glu Lys Ile Phe
275 280 285
Gln Gly Phe Ala Gln Glu Leu Asp Leu Val Val Asp Lys Ala Lys Ala
290 295 300
Gly Thr Ala Thr Glu Val Asp Leu Ala Ala Val Asp Leu Ser Ala Tyr
305 310 315 320
Gln Ala Gln Leu Ala Val Ala Pro Leu Val Leu Ser Gln Ala Thr Gln
325 330 335
Ala Phe Glu Val Gly Ala Asp Ala Leu Asn Gly Gly His Val Ala Ala
340 345 350
Gln Tyr Thr Ile Gly Ser Leu Ser
355 360
<210> 151
<211> 516
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(493)
<223> RXN03065
<400> 151
gacggcgcca actctgcatt cttcgcctca gcgtgcgtgg cagtgtttgc actgatcgtg 60
ggcttctttg taaagaggcc agcccgctaa gctaggtcgc atg atc agc att gga 115
Met Ile Ser Ile Gly
1 5
acc gac ctc gtt cac att tcg gcg ttc gca gag cag ctt gca cag ccg 163
Thr Asp Leu Val His Ile Ser Ala Phe Ala Glu Gln Leu Ala Gln Pro
10 15 20
gga agt tcc ttc atg gag gtg ttt tcc gca ggg gag cgt cgt aaa gca 211
Gly Ser Ser Phe Met Glu Val Phe Ser Ala Gly Glu Arg Arg Lys Ala
25 30 35
aat gaa cgc cag gca agc cgc tac gcc gag cat ttg gcg ggg cgg tgg 259
Asn Glu Arg Gln Ala Ser Arg Tyr Ala Glu His Leu Ala Gly Arg Trp
40 45 50
gcg gca aaa gaa tcc ttt att aag gcc tgg tca cag gcc att tat ggc 307
Ala Ala Lys Glu Ser Phe Ile Lys Ala Trp Ser Gln Ala Ile Tyr Gly
55 60 65
cag cca ccc gtg atc gcc gaa gaa gcc gtg gtg tgg cgg gac atc gaa 355
Gln Pro Pro Val Ile Ala Glu Glu Ala Val Val Trp Arg Asp Ile Glu
70 75 80 85
gtt cgc gca gac gcg tgg ggg cgc gtc gcg atc gaa ttg gcg ccc gaa 403
Val Arg Ala Asp Ala Trp Gly Arg Val Ala Ile Glu Leu Ala Pro Glu
90 95 100
ttg gcc gca gtg gtc cgg gaa tcc atc ggg gag ttt tcc agc agc ttg 451
Leu Ala Ala Val Val Arg Glu Ser Ile Gly Glu Phe Ser Ser Ser Leu
105 110 115
agc atc agc cac gac ggc gac tac gcg gtg gaa cgt gcg tgt 493
Ser Ile Ser His Asp Gly Asp Tyr Ala Val Glu Arg Ala Cys
120 125 130
tgactatcca gtagccacgg aga 516
<210> 152
<211> 131
<212> PRT
<213> Corynebacterium glutamicum
<400> 152
Met Ile Ser Ile Gly Thr Asp Leu Val His Ile Ser Ala Phe Ala Glu
1 5 10 15
Gln Leu Ala Gln Pro Gly Ser Ser Phe Met Glu Val Phe Ser Ala Gly
20 25 30
Glu Arg Arg Lys Ala Asn Glu Arg Gln Ala Ser Arg Tyr Ala Glu His
35 40 45
Leu Ala Gly Arg Trp Ala Ala Lys Glu Ser Phe Ile Lys Ala Trp Ser
50 55 60
Gln Ala Ile Tyr Gly Gln Pro Pro Val Ile Ala Glu Glu Ala Val Val
65 70 75 80
Trp Arg Asp Ile Glu Val Arg Ala Asp Ala Trp Gly Arg Val Ala Ile
85 90 95
Glu Leu Ala Pro Glu Leu Ala Ala Val Val Arg Glu Ser Ile Gly Glu
100 105 110
Phe Ser Ser Ser Leu Ser Ile Ser His Asp Gly Asp Tyr Ala Val Glu
115 120 125
Arg Ala Cys
130
<210> 153
<211> 543
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(520)
<223> RXN03132
<400> 153
taacttattt atacataaaa acacaataaa aaccgcacac gcggcgaaac ttcaataaat 60
ccctagactg caaaaaatgg ttaggctaac cttatttcca atg aat gtg aat caa 115
Met Asn Val Asn Gln
1 5
cag ttg gga gcc cgc acc gcc atg aac cac cct gag acc gca acc gtc 163
Gln Leu Gly Ala Arg Thr Ala Met Asn His Pro Glu Thr Ala Thr Val
10 15 20
ctt cgc tcc atc tct gac atg gtt agc acc gaa acc aat ccg cgc cgt 211
Leu Arg Ser Ile Ser Asp Met Val Ser Thr Glu Thr Asn Pro Arg Arg
25 30 35
aaa agc cgc ctc gag cag ctc att tac gcc acc gcc agc gcc tgg ccc 259
Lys Ser Arg Leu Glu Gln Leu Ile Tyr Ala Thr Ala Ser Ala Trp Pro
40 45 50
cac tac ccc att gcc cac gca gcc cag gcc gcg gtg caa tta gcc agg 307
His Tyr Pro Ile Ala His Ala Ala Gln Ala Ala Val Gln Leu Ala Arg
55 60 65
cca atg cgg gtt ttt gag ctc cag agc ttt gaa ggc gtc aag cac gca 355
Pro Met Arg Val Phe Glu Leu Gln Ser Phe Glu Gly Val Lys His Ala
70 75 80 85
ctc cac cac atc gat ctt cgc ccc gcc ctc gaa tgg gac atc atg gga 403
Leu His His Ile Asp Leu Arg Pro Ala Leu Glu Trp Asp Ile Met Gly
90 95 100
ttt ccc gaa tcc ccc gac acg ctg ccc att ttg ctc agt gac ctg cgc 451
Phe Pro Glu Ser Pro Asp Thr Leu Pro Ile Leu Leu Ser Asp Leu Arg
105 110 115
gac ccc cct tac gcc acc act gct gtg cca cct caa tcc acg cca cgc 499
Asp Pro Pro Tyr Ala Thr Thr Ala Val Pro Pro Gln Ser Thr Pro Arg
120 125 130
tcc gct cac cga tcc aca cat tgacgcttcc aggcgccacc gcg 543
Ser Ala His Arg Ser Thr His
135 140
<210> 154
<211> 140
<212> PRT
<213> Corynebacterium glutamicum
<400> 154
Met Asn Val Asn Gln Gln Leu Gly Ala Arg Thr Ala Met Asn His Pro
1 5 10 15
Glu Thr Ala Thr Val Leu Arg Ser Ile Ser Asp Met Val Ser Thr Glu
20 25 30
Thr Asn Pro Arg Arg Lys Ser Arg Leu Glu Gln Leu Ile Tyr Ala Thr
35 40 45
Ala Ser Ala Trp Pro His Tyr Pro Ile Ala His Ala Ala Gln Ala Ala
50 55 60
Val Gln Leu Ala Arg Pro Met Arg Val Phe Glu Leu Gln Ser Phe Glu
65 70 75 80
Gly Val Lys His Ala Leu His His Ile Asp Leu Arg Pro Ala Leu Glu
85 90 95
Trp Asp Ile Met Gly Phe Pro Glu Ser Pro Asp Thr Leu Pro Ile Leu
100 105 110
Leu Ser Asp Leu Arg Asp Pro Pro Tyr Ala Thr Thr Ala Val Pro Pro
115 120 125
Gln Ser Thr Pro Arg Ser Ala His Arg Ser Thr His
130 135 140
<210> 155
<211> 461
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(438)
<223> RXN03157
<400> 155
ggc cac ctc gac atc gtg acc cgc gcc gcc gcg caa ttt agc gaa gtc 48
Gly His Leu Asp Ile Val Thr Arg Ala Ala Ala Gln Phe Ser Glu Val
1 5 10 15
acc atc ttg gtc acc gcc aac ccc aac aaa aac tca gga ctg ttc acc 96
Thr Ile Leu Val Thr Ala Asn Pro Asn Lys Asn Ser Gly Leu Phe Thr
20 25 30
gtc gca gaa cgc atg gat ctc atc cgc gaa tcc acc gca cac ctg gac 144
Val Ala Glu Arg Met Asp Leu Ile Arg Glu Ser Thr Ala His Leu Asp
35 40 45
aac gta aaa gta gac act tgg gcc tca ctg ctc gtg gat tac acc acc 192
Asn Val Lys Val Asp Thr Trp Ala Ser Leu Leu Val Asp Tyr Thr Thr
50 55 60
gaa cat ggc atc ggc gcc cta gtc aaa ggc ctg cga agc tcc ctc gac 240
Glu His Gly Ile Gly Ala Leu Val Lys Gly Leu Arg Ser Ser Leu Asp
65 70 75 80
tac gaa tac gag ctc ccc atg gca cag atg aac agg cga ctc acg ggc 288
Tyr Glu Tyr Glu Leu Pro Met Ala Gln Met Asn Arg Arg Leu Thr Gly
85 90 95
gta gac acc ttc ttc ctc ctc acc gac gag aaa tac ggc tac gtc agc 336
Val Asp Thr Phe Phe Leu Leu Thr Asp Glu Lys Tyr Gly Tyr Val Ser
100 105 110
tcc aca ctg tgc aaa gaa gtt gcc cgc ttc ggt ggc gat gtc tcc ggc 384
Ser Thr Leu Cys Lys Glu Val Ala Arg Phe Gly Gly Asp Val Ser Gly
115 120 125
ctc cta cct gag gta gtg gca aaa gcc gtg aca gaa aaa tac agc aac 432
Leu Leu Pro Glu Val Val Ala Lys Ala Val Thr Glu Lys Tyr Ser Asn
130 135 140
cag cac tagtttcttt tgcatcaagc gtc 461
Gln His
145
<210> 156
<211> 146
<212> PRT
<213> Corynebacterium glutamicum
<400> 156
Gly His Leu Asp Ile Val Thr Arg Ala Ala Ala Gln Phe Ser Glu Val
1 5 10 15
Thr Ile Leu Val Thr Ala Asn Pro Asn Lys Asn Ser Gly Leu Phe Thr
20 25 30
Val Ala Glu Arg Met Asp Leu Ile Arg Glu Ser Thr Ala His Leu Asp
35 40 45
Asn Val Lys Val Asp Thr Trp Ala Ser Leu Leu Val Asp Tyr Thr Thr
50 55 60
Glu His Gly Ile Gly Ala Leu Val Lys Gly Leu Arg Ser Ser Leu Asp
65 70 75 80
Tyr Glu Tyr Glu Leu Pro Met Ala Gln Met Asn Arg Arg Leu Thr Gly
85 90 95
Val Asp Thr Phe Phe Leu Leu Thr Asp Glu Lys Tyr Gly Tyr Val Ser
100 105 110
Ser Thr Leu Cys Lys Glu Val Ala Arg Phe Gly Gly Asp Val Ser Gly
115 120 125
Leu Leu Pro Glu Val Val Ala Lys Ala Val Thr Glu Lys Tyr Ser Asn
130 135 140
Gln His
145
<210> 157
<211> 1206
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1183)
<223> RXN00934
<400> 157
ccaacccctg tggtttggtg atttggatcc ggagcgtctc aagcgctcta gggagcagac 60
aaatgttcac aaaccggtgg cattacagga ggacaattag gtg cga att gga atg 115
Val Arg Ile Gly Met
1 5
gtc tgc ccg tac tcc ttc gat gag ccg ggc ggt gtt caa gcg cat atc 163
Val Cys Pro Tyr Ser Phe Asp Glu Pro Gly Gly Val Gln Ala His Ile
10 15 20
ctt gac tta gcg cga acc ttc att gcc caa ggc cat gag gtt cag gtg 211
Leu Asp Leu Ala Arg Thr Phe Ile Ala Gln Gly His Glu Val Gln Val
25 30 35
ctt ggt ccg tgt agt gcg gat acg cag gtg ccc gat ttc gtg gtg cgc 259
Leu Gly Pro Cys Ser Ala Asp Thr Gln Val Pro Asp Phe Val Val Arg
40 45 50
ggt ggt ggc agc atc ccg att ccg tac aat ggc tcg gtt gcc cgc ttg 307
Gly Gly Gly Ser Ile Pro Ile Pro Tyr Asn Gly Ser Val Ala Arg Leu
55 60 65
agc ttt ggg ccg aaa atg ttc aag gcc gtg cgc acg ttc ctc cgc gaa 355
Ser Phe Gly Pro Lys Met Phe Lys Ala Val Arg Thr Phe Leu Arg Glu
70 75 80 85
ggc aac ttc gat gtg ctg cat atc cat gaa ccg aat tca cca agt ttt 403
Gly Asn Phe Asp Val Leu His Ile His Glu Pro Asn Ser Pro Ser Phe
90 95 100
tcc atg gcg gcg cta cgc ttt gcg gaa ggc ccc atc gtt gct act tac 451
Ser Met Ala Ala Leu Arg Phe Ala Glu Gly Pro Ile Val Ala Thr Tyr
105 110 115
cac gcc tcc agt agc gga tcg aag ctg ctc aag gct ttc tta cca gtg 499
His Ala Ser Ser Ser Gly Ser Lys Leu Leu Lys Ala Phe Leu Pro Val
120 125 130
ctt tcg ccc atg ctg gag aaa gtg cgc gca ggc atc gcc gtg tct gaa 547
Leu Ser Pro Met Leu Glu Lys Val Arg Ala Gly Ile Ala Val Ser Glu
135 140 145
atg gct cgg cgc tgg cag gtg gag caa gtc ggc ggc gat ccc gtg ctg 595
Met Ala Arg Arg Trp Gln Val Glu Gln Val Gly Gly Asp Pro Val Leu
150 155 160 165
atc ccc aac ggg gta gag acc tcc atg ttc aaa gcc gcg cgc caa atc 643
Ile Pro Asn Gly Val Glu Thr Ser Met Phe Lys Ala Ala Arg Gln Ile
170 175 180
gaa ccg aat gat cct gta gag atc gtc ttt ttg ggt cgc ctc gat gag 691
Glu Pro Asn Asp Pro Val Glu Ile Val Phe Leu Gly Arg Leu Asp Glu
185 190 195
tcc cgc aaa ggc ctc gac atc ctc ctg cgc gct ctg acc agg ctg gat 739
Ser Arg Lys Gly Leu Asp Ile Leu Leu Arg Ala Leu Thr Arg Leu Asp
200 205 210
cgc ccg ttt acc tgc acc gtc att ggc ggc ggc acc ccg cga gaa gtc 787
Arg Pro Phe Thr Cys Thr Val Ile Gly Gly Gly Thr Pro Arg Glu Val
215 220 225
gcc ggc atc aac ttt gtg ggc cgc gtc agc gat gag gaa aag gca gca 835
Ala Gly Ile Asn Phe Val Gly Arg Val Ser Asp Glu Glu Lys Ala Ala
230 235 240 245
atc tta ggt cgc gca gac atc tat gtc gca ccc aac acc ggc ggc gaa 883
Ile Leu Gly Arg Ala Asp Ile Tyr Val Ala Pro Asn Thr Gly Gly Glu
250 255 260
agc ttc ggc atc gtg cta gtt gaa gcg atg gcc gcg gga tgc gct gtc 931
Ser Phe Gly Ile Val Leu Val Glu Ala Met Ala Ala Gly Cys Ala Val
265 270 275
gtc gcc agc gac cta gaa gcg ttc tcc ctg gtc acc gat tct gaa gcc 979
Val Ala Ser Asp Leu Glu Ala Phe Ser Leu Val Thr Asp Ser Glu Ala
280 285 290
gca cag cca gcg ggc gtg cta ttt aaa acc ggc tca gac gcc gac cta 1027
Ala Gln Pro Ala Gly Val Leu Phe Lys Thr Gly Ser Asp Ala Asp Leu
295 300 305
gcc aaa aaa ctt caa gcg ctt atc gac gac ccc tcc tcc cgt tcc acg 1075
Ala Lys Lys Leu Gln Ala Leu Ile Asp Asp Pro Ser Ser Arg Ser Thr
310 315 320 325
ctt atc gcc gcg ggg cta aag cgc gca aac gcc tac gac tgg tcg aca 1123
Leu Ile Ala Ala Gly Leu Lys Arg Ala Asn Ala Tyr Asp Trp Ser Thr
330 335 340
gta tcc acc cag gtc atg gca gtc tat gaa acc att gcg atc gac aaa 1171
Val Ser Thr Gln Val Met Ala Val Tyr Glu Thr Ile Ala Ile Asp Lys
345 350 355
gtg agg ctt gga tgacccttgt ttacctcctc atc 1206
Val Arg Leu Gly
360
<210> 158
<211> 361
<212> PRT
<213> Corynebacterium glutamicum
<400> 158
Val Arg Ile Gly Met Val Cys Pro Tyr Ser Phe Asp Glu Pro Gly Gly
1 5 10 15
Val Gln Ala His Ile Leu Asp Leu Ala Arg Thr Phe Ile Ala Gln Gly
20 25 30
His Glu Val Gln Val Leu Gly Pro Cys Ser Ala Asp Thr Gln Val Pro
35 40 45
Asp Phe Val Val Arg Gly Gly Gly Ser Ile Pro Ile Pro Tyr Asn Gly
50 55 60
Ser Val Ala Arg Leu Ser Phe Gly Pro Lys Met Phe Lys Ala Val Arg
65 70 75 80
Thr Phe Leu Arg Glu Gly Asn Phe Asp Val Leu His Ile His Glu Pro
85 90 95
Asn Ser Pro Ser Phe Ser Met Ala Ala Leu Arg Phe Ala Glu Gly Pro
100 105 110
Ile Val Ala Thr Tyr His Ala Ser Ser Ser Gly Ser Lys Leu Leu Lys
115 120 125
Ala Phe Leu Pro Val Leu Ser Pro Met Leu Glu Lys Val Arg Ala Gly
130 135 140
Ile Ala Val Ser Glu Met Ala Arg Arg Trp Gln Val Glu Gln Val Gly
145 150 155 160
Gly Asp Pro Val Leu Ile Pro Asn Gly Val Glu Thr Ser Met Phe Lys
165 170 175
Ala Ala Arg Gln Ile Glu Pro Asn Asp Pro Val Glu Ile Val Phe Leu
180 185 190
Gly Arg Leu Asp Glu Ser Arg Lys Gly Leu Asp Ile Leu Leu Arg Ala
195 200 205
Leu Thr Arg Leu Asp Arg Pro Phe Thr Cys Thr Val Ile Gly Gly Gly
210 215 220
Thr Pro Arg Glu Val Ala Gly Ile Asn Phe Val Gly Arg Val Ser Asp
225 230 235 240
Glu Glu Lys Ala Ala Ile Leu Gly Arg Ala Asp Ile Tyr Val Ala Pro
245 250 255
Asn Thr Gly Gly Glu Ser Phe Gly Ile Val Leu Val Glu Ala Met Ala
260 265 270
Ala Gly Cys Ala Val Val Ala Ser Asp Leu Glu Ala Phe Ser Leu Val
275 280 285
Thr Asp Ser Glu Ala Ala Gln Pro Ala Gly Val Leu Phe Lys Thr Gly
290 295 300
Ser Asp Ala Asp Leu Ala Lys Lys Leu Gln Ala Leu Ile Asp Asp Pro
305 310 315 320
Ser Ser Arg Ser Thr Leu Ile Ala Ala Gly Leu Lys Arg Ala Asn Ala
325 330 335
Tyr Asp Trp Ser Thr Val Ser Thr Gln Val Met Ala Val Tyr Glu Thr
340 345 350
Ile Ala Ile Asp Lys Val Arg Leu Gly
355 360
<210> 159
<211> 1320
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1297)
<223> RXN00792
<400> 159
cacctttggt gctgagccag gccacccagg cctttgaggt tggcgcagat gccttaaacg 60
gcggccacgt ggctgcccaa tacacgatcg gatccttgtc atg agc caa gaa att 115
Met Ser Gln Glu Ile
1 5
ttg agc cat ttt gca ccc gca tta gag cgc att cga agc ggc gcc gtc 163
Leu Ser His Phe Ala Pro Ala Leu Glu Arg Ile Arg Ser Gly Ala Val
10 15 20
gag cgc gaa cag cag cgc gcc ttg cca gtg gaa gag att aaa gag ctg 211
Glu Arg Glu Gln Gln Arg Ala Leu Pro Val Glu Glu Ile Lys Glu Leu
25 30 35
gta gag cta ggt ttt act ggg ctt cga gtg ccc gaa gaa cta ggc ggt 259
Val Glu Leu Gly Phe Thr Gly Leu Arg Val Pro Glu Glu Leu Gly Gly
40 45 50
gcg ggc gct tcc ctg gaa agc gta gtt gag tta ctg atc gag atc gcg 307
Ala Gly Ala Ser Leu Glu Ser Val Val Glu Leu Leu Ile Glu Ile Ala
55 60 65
ggc gcc gat tcc aat atc gcc caa gcc ctg cgc gga cat ttt gcc ttc 355
Gly Ala Asp Ser Asn Ile Ala Gln Ala Leu Arg Gly His Phe Ala Phe
70 75 80 85
gtg gaa cta ctc ctg gaa gcg ccg gag agc gaa ttc cgc acc cat tgg 403
Val Glu Leu Leu Leu Glu Ala Pro Glu Ser Glu Phe Arg Thr His Trp
90 95 100
ctg cgc gaa gtc gcc acc gga aga ctt gtg ggc aac gcc gaa agt gag 451
Leu Arg Glu Val Ala Thr Gly Arg Leu Val Gly Asn Ala Glu Ser Glu
105 110 115
aaa cgc ggc gtt tac ggc gat ccg cag acc ttc atc gat gag gtg gag 499
Lys Arg Gly Val Tyr Gly Asp Pro Gln Thr Phe Ile Asp Glu Val Glu
120 125 130
act gaa aac gga ccg att ttc gtg ctc aac ggc act aag ttt tat acc 547
Thr Glu Asn Gly Pro Ile Phe Val Leu Asn Gly Thr Lys Phe Tyr Thr
135 140 145
acc ggc acc tat ttt gcg gac tac acc tgg acc acc gcg ctg ctg cgc 595
Thr Gly Thr Tyr Phe Ala Asp Tyr Thr Trp Thr Thr Ala Leu Leu Arg
150 155 160 165
aac ctt aac ggc caa gaa act ttg gtc agt ttg ccg gtc gat ctg cac 643
Asn Leu Asn Gly Gln Glu Thr Leu Val Ser Leu Pro Val Asp Leu His
170 175 180
gcg ccg ggc gtg gat gtt gct gat gat tgg agc ggg ttt ggg caa aag 691
Ala Pro Gly Val Asp Val Ala Asp Asp Trp Ser Gly Phe Gly Gln Lys
185 190 195
ctc acc gcc tct gga acg acc acg ttt aaa gac ctg gag gtg gat ccg 739
Leu Thr Ala Ser Gly Thr Thr Thr Phe Lys Asp Leu Glu Val Asp Pro
200 205 210
cgg tgg atc att cca cgc act gat gcg ccc acg ctg gtg tgg acg tat 787
Arg Trp Ile Ile Pro Arg Thr Asp Ala Pro Thr Leu Val Trp Thr Tyr
215 220 225
ctg cag ctg agc ctg ctg acc gtg ctg gtt ggc agt gcc gca gca gct 835
Leu Gln Leu Ser Leu Leu Thr Val Leu Val Gly Ser Ala Ala Ala Ala
230 235 240 245
gtc gat gag gtg gtt gcc cgc gcc caa tcc tcc acc aga aat gcg tgg 883
Val Asp Glu Val Val Ala Arg Ala Gln Ser Ser Thr Arg Asn Ala Trp
250 255 260
aac cct ggc gtc gag cgc cgc agc gat ccg gcc gca acc ata gcg atc 931
Asn Pro Gly Val Glu Arg Arg Ser Asp Pro Ala Ala Thr Ile Ala Ile
265 270 275
ggc gac gca cgc agc cga gtc acc gtt att cgt gga gcg ctt ctc gac 979
Gly Asp Ala Arg Ser Arg Val Thr Val Ile Arg Gly Ala Leu Leu Asp
280 285 290
gcc acc cgc cac gtt tcc aac gcc gcc acg atc gta acc ccc gaa gcc 1027
Ala Thr Arg His Val Ser Asn Ala Ala Thr Ile Val Thr Pro Glu Ala
295 300 305
ttc aac gag gcg gac gct att gtt gca gcg ctc tgg ccc atc gtc tcc 1075
Phe Asn Glu Ala Asp Ala Ile Val Ala Ala Leu Trp Pro Ile Val Ser
310 315 320 325
gga caa gct ttg gtg gtg aca tcc aac gtt ttc gat gcg gtg ggt gca 1123
Gly Gln Ala Leu Val Val Thr Ser Asn Val Phe Asp Ala Val Gly Ala
330 335 340
tct gca gtg ctt ggt gag cat tcc att gat cgc cac tgg cgc aat gtg 1171
Ser Ala Val Leu Gly Glu His Ser Ile Asp Arg His Trp Arg Asn Val
345 350 355
cgt acc gtg tcc tca aac aac ccg gtg ttc ctg gcc aag aat gca gtg 1219
Arg Thr Val Ser Ser Asn Asn Pro Val Phe Leu Ala Lys Asn Ala Val
360 365 370
ggg gag tat gcc ctc aac ggc act cct gtg ggt acc aac att ggt aaa 1267
Gly Glu Tyr Ala Leu Asn Gly Thr Pro Val Gly Thr Asn Ile Gly Lys
375 380 385
gca ctg agc cgt ccg gtg agc cta agc agc tagacgtgtg atttcgctgg 1317
Ala Leu Ser Arg Pro Val Ser Leu Ser Ser
390 395
ttt 1320
<210> 160
<211> 399
<212> PRT
<213> Corynebacterium glutamicum
<400> 160
Met Ser Gln Glu Ile Leu Ser His Phe Ala Pro Ala Leu Glu Arg Ile
1 5 10 15
Arg Ser Gly Ala Val Glu Arg Glu Gln Gln Arg Ala Leu Pro Val Glu
20 25 30
Glu Ile Lys Glu Leu Val Glu Leu Gly Phe Thr Gly Leu Arg Val Pro
35 40 45
Glu Glu Leu Gly Gly Ala Gly Ala Ser Leu Glu Ser Val Val Glu Leu
50 55 60
Leu Ile Glu Ile Ala Gly Ala Asp Ser Asn Ile Ala Gln Ala Leu Arg
65 70 75 80
Gly His Phe Ala Phe Val Glu Leu Leu Leu Glu Ala Pro Glu Ser Glu
85 90 95
Phe Arg Thr His Trp Leu Arg Glu Val Ala Thr Gly Arg Leu Val Gly
100 105 110
Asn Ala Glu Ser Glu Lys Arg Gly Val Tyr Gly Asp Pro Gln Thr Phe
115 120 125
Ile Asp Glu Val Glu Thr Glu Asn Gly Pro Ile Phe Val Leu Asn Gly
130 135 140
Thr Lys Phe Tyr Thr Thr Gly Thr Tyr Phe Ala Asp Tyr Thr Trp Thr
145 150 155 160
Thr Ala Leu Leu Arg Asn Leu Asn Gly Gln Glu Thr Leu Val Ser Leu
165 170 175
Pro Val Asp Leu His Ala Pro Gly Val Asp Val Ala Asp Asp Trp Ser
180 185 190
Gly Phe Gly Gln Lys Leu Thr Ala Ser Gly Thr Thr Thr Phe Lys Asp
195 200 205
Leu Glu Val Asp Pro Arg Trp Ile Ile Pro Arg Thr Asp Ala Pro Thr
210 215 220
Leu Val Trp Thr Tyr Leu Gln Leu Ser Leu Leu Thr Val Leu Val Gly
225 230 235 240
Ser Ala Ala Ala Ala Val Asp Glu Val Val Ala Arg Ala Gln Ser Ser
245 250 255
Thr Arg Asn Ala Trp Asn Pro Gly Val Glu Arg Arg Ser Asp Pro Ala
260 265 270
Ala Thr Ile Ala Ile Gly Asp Ala Arg Ser Arg Val Thr Val Ile Arg
275 280 285
Gly Ala Leu Leu Asp Ala Thr Arg His Val Ser Asn Ala Ala Thr Ile
290 295 300
Val Thr Pro Glu Ala Phe Asn Glu Ala Asp Ala Ile Val Ala Ala Leu
305 310 315 320
Trp Pro Ile Val Ser Gly Gln Ala Leu Val Val Thr Ser Asn Val Phe
325 330 335
Asp Ala Val Gly Ala Ser Ala Val Leu Gly Glu His Ser Ile Asp Arg
340 345 350
His Trp Arg Asn Val Arg Thr Val Ser Ser Asn Asn Pro Val Phe Leu
355 360 365
Ala Lys Asn Ala Val Gly Glu Tyr Ala Leu Asn Gly Thr Pro Val Gly
370 375 380
Thr Asn Ile Gly Lys Ala Leu Ser Arg Pro Val Ser Leu Ser Ser
385 390 395
<210> 161
<211> 969
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(946)
<223> RXN00931
<400> 161
ccgtaaccta atcgttgaaa catcacctta ttgctgggct ttgcacgcta ctctttgtga 60
gtaacctcac cgaagtgcat aaattaattg ggagtgatca gtg aaa act att gaa 115
Val Lys Thr Ile Glu
1 5
gat att ttg acc ttg gaa gaa atc gac cgc gat att tac cgt ggt ccc 163
Asp Ile Leu Thr Leu Glu Glu Ile Asp Arg Asp Ile Tyr Arg Gly Pro
10 15 20
gtt atc gaa tct tat tta gcc agg act ttc ggt ggc cag gtc gct gcc 211
Val Ile Glu Ser Tyr Leu Ala Arg Thr Phe Gly Gly Gln Val Ala Ala
25 30 35
caa gct tta gta gca gca acg cat act gtt gat aaa gcc ttt act gtg 259
Gln Ala Leu Val Ala Ala Thr His Thr Val Asp Lys Ala Phe Thr Val
40 45 50
cat tct ttg cat ggc tac ttt ata gct cct ggt gat cca aca gca ccc 307
His Ser Leu His Gly Tyr Phe Ile Ala Pro Gly Asp Pro Thr Ala Pro
55 60 65
gca att tat tta gtg gat cga gtt cgc gac gga aaa agc tac gtc acc 355
Ala Ile Tyr Leu Val Asp Arg Val Arg Asp Gly Lys Ser Tyr Val Thr
70 75 80 85
cgc tcg gtg cgt ggc atc caa gac ggc gaa gta atc ttc agc atg cag 403
Arg Ser Val Arg Gly Ile Gln Asp Gly Glu Val Ile Phe Ser Met Gln
90 95 100
gcc agc ttt cat cgt ggg gat gaa ggc att gag cac atg gac aag atg 451
Ala Ser Phe His Arg Gly Asp Glu Gly Ile Glu His Met Asp Lys Met
105 110 115
cgt aaa gtt cca gct cct gat gag atc aag gga aca gta gaa cgt atg 499
Arg Lys Val Pro Ala Pro Asp Glu Ile Lys Gly Thr Val Glu Arg Met
120 125 130
ccg atc tca agt agg cga gtg ctt gat gaa tgg gcg gaa tgg gat atc 547
Pro Ile Ser Ser Arg Arg Val Leu Asp Glu Trp Ala Glu Trp Asp Ile
135 140 145
cgc gtt att ccg cag gat caa tta gaa ctc agc gat ttc acc gct act 595
Arg Val Ile Pro Gln Asp Gln Leu Glu Leu Ser Asp Phe Thr Ala Thr
150 155 160 165
gag caa gct gtg tgg att cgg tgc acc gct gat ctt ccg gat aat ccc 643
Glu Gln Ala Val Trp Ile Arg Cys Thr Ala Asp Leu Pro Asp Asn Pro
170 175 180
acc ttc cac cag tgc tca ctg act tat ctg tcc gat atg act ttg ctg 691
Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser Asp Met Thr Leu Leu
185 190 195
cat agt gcc ctg gtg cca cac cca ggt gag aaa atg cag atg gcc tca 739
His Ser Ala Leu Val Pro His Pro Gly Glu Lys Met Gln Met Ala Ser
200 205 210
ctt gat cac gct gtg tgg ttc ctg cgt ccc ttc cgc gtc gat gaa tgg 787
Leu Asp His Ala Val Trp Phe Leu Arg Pro Phe Arg Val Asp Glu Trp
215 220 225
ttg ctt tat gat cag cgc tct cca tcg gcc tca agt ggg cga gcc ttg 835
Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser Ser Gly Arg Ala Leu
230 235 240 245
act cac ggg cgg ctt ttc aac cag cag gga gat ttg gtc gct att gtc 883
Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp Leu Val Ala Ile Val
250 255 260
aat caa gag gga atg acc cgc aca ctc cac gag ggt gcg caa tca att 931
Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu Gly Ala Gln Ser Ile
265 270 275
ccg atg cgc aaa gac taaaatgcag cgaacttgaa gat 969
Pro Met Arg Lys Asp
280
<210> 162
<211> 282
<212> PRT
<213> Corynebacterium glutamicum
<400> 162
Val Lys Thr Ile Glu Asp Ile Leu Thr Leu Glu Glu Ile Asp Arg Asp
1 5 10 15
Ile Tyr Arg Gly Pro Val Ile Glu Ser Tyr Leu Ala Arg Thr Phe Gly
20 25 30
Gly Gln Val Ala Ala Gln Ala Leu Val Ala Ala Thr His Thr Val Asp
35 40 45
Lys Ala Phe Thr Val His Ser Leu His Gly Tyr Phe Ile Ala Pro Gly
50 55 60
Asp Pro Thr Ala Pro Ala Ile Tyr Leu Val Asp Arg Val Arg Asp Gly
65 70 75 80
Lys Ser Tyr Val Thr Arg Ser Val Arg Gly Ile Gln Asp Gly Glu Val
85 90 95
Ile Phe Ser Met Gln Ala Ser Phe His Arg Gly Asp Glu Gly Ile Glu
100 105 110
His Met Asp Lys Met Arg Lys Val Pro Ala Pro Asp Glu Ile Lys Gly
115 120 125
Thr Val Glu Arg Met Pro Ile Ser Ser Arg Arg Val Leu Asp Glu Trp
130 135 140
Ala Glu Trp Asp Ile Arg Val Ile Pro Gln Asp Gln Leu Glu Leu Ser
145 150 155 160
Asp Phe Thr Ala Thr Glu Gln Ala Val Trp Ile Arg Cys Thr Ala Asp
165 170 175
Leu Pro Asp Asn Pro Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser
180 185 190
Asp Met Thr Leu Leu His Ser Ala Leu Val Pro His Pro Gly Glu Lys
195 200 205
Met Gln Met Ala Ser Leu Asp His Ala Val Trp Phe Leu Arg Pro Phe
210 215 220
Arg Val Asp Glu Trp Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser
225 230 235 240
Ser Gly Arg Ala Leu Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp
245 250 255
Leu Val Ala Ile Val Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu
260 265 270
Gly Ala Gln Ser Ile Pro Met Arg Lys Asp
275 280
<210> 163
<211> 969
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(946)
<223> FRXA00931
<400> 163
ccgtaaccta atcgttgaaa catcacctta ttgctgggct ttgcacgcta ctctttgtga 60
gtaacctcac cgaagtgcat aaattaattg ggagtgatca gtg aaa act att gaa 115
Val Lys Thr Ile Glu
1 5
gat att ttg acc ttg gaa gaa atc gac cgc gat att tac cgt ggt ccc 163
Asp Ile Leu Thr Leu Glu Glu Ile Asp Arg Asp Ile Tyr Arg Gly Pro
10 15 20
gtt atc gaa tct tat tta gcc agg act ttc ggt ggc cag gtc gct gcc 211
Val Ile Glu Ser Tyr Leu Ala Arg Thr Phe Gly Gly Gln Val Ala Ala
25 30 35
caa gct tta gta gca gca acg cat act gtt gat aaa gcc ttt act gtg 259
Gln Ala Leu Val Ala Ala Thr His Thr Val Asp Lys Ala Phe Thr Val
40 45 50
cat tct ttg cat ggc tac ttt ata gct cct ggt gat cca aca gca ccc 307
His Ser Leu His Gly Tyr Phe Ile Ala Pro Gly Asp Pro Thr Ala Pro
55 60 65
gca att tat tta gtg gat cga gtt cgc gac gga aaa agc tac gtc acc 355
Ala Ile Tyr Leu Val Asp Arg Val Arg Asp Gly Lys Ser Tyr Val Thr
70 75 80 85
cgc tcg gtg cgt ggc atc caa gac ggc gaa gta atc ttc agc atg cag 403
Arg Ser Val Arg Gly Ile Gln Asp Gly Glu Val Ile Phe Ser Met Gln
90 95 100
gcc agc ttt cat cgt ggg gat gaa ggc att gag cac atg gac aag atg 451
Ala Ser Phe His Arg Gly Asp Glu Gly Ile Glu His Met Asp Lys Met
105 110 115
cgt aaa gtt cca gct cct gat gag atc aag gga aca gta gaa cgt atg 499
Arg Lys Val Pro Ala Pro Asp Glu Ile Lys Gly Thr Val Glu Arg Met
120 125 130
ccg atc tca agt agg cga gtg ctt gat gaa tgg gcg gaa tgg gat atc 547
Pro Ile Ser Ser Arg Arg Val Leu Asp Glu Trp Ala Glu Trp Asp Ile
135 140 145
cgc gtt att ccg cag gat caa tta gaa ctc agc gat ttc acc gct act 595
Arg Val Ile Pro Gln Asp Gln Leu Glu Leu Ser Asp Phe Thr Ala Thr
150 155 160 165
gag caa gct gtg tgg att cgg tgc acc gct gat ctt ccg gat aat ccc 643
Glu Gln Ala Val Trp Ile Arg Cys Thr Ala Asp Leu Pro Asp Asn Pro
170 175 180
acc ttc cac cag tgc tca ctg act tat ctg tcc gat atg act ttg ctg 691
Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser Asp Met Thr Leu Leu
185 190 195
cat agt gcc ctg gtg cca cac cca ggt gag aaa atg cag atg gcc tca 739
His Ser Ala Leu Val Pro His Pro Gly Glu Lys Met Gln Met Ala Ser
200 205 210
ctt gat cac gct gtg tgg ttc ctg cgt ccc ttc cgc gtc gat gaa tgg 787
Leu Asp His Ala Val Trp Phe Leu Arg Pro Phe Arg Val Asp Glu Trp
215 220 225
ttg ctt tat gat cag cgc tct cca tcg gcc tca agt ggg cga gcc ttg 835
Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser Ser Gly Arg Ala Leu
230 235 240 245
act cac ggg cgg ctt ttc aac cag cag gga gat ttg gtc gct att gtc 883
Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp Leu Val Ala Ile Val
250 255 260
aat caa gag gga atg acc cgc aca ctc cac gag ggt gcg caa tca att 931
Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu Gly Ala Gln Ser Ile
265 270 275
ccg atg cgc aaa gac taaaatgcag cgaacttgaa gat 969
Pro Met Arg Lys Asp
280
<210> 164
<211> 282
<212> PRT
<213> Corynebacterium glutamicum
<400> 164
Val Lys Thr Ile Glu Asp Ile Leu Thr Leu Glu Glu Ile Asp Arg Asp
1 5 10 15
Ile Tyr Arg Gly Pro Val Ile Glu Ser Tyr Leu Ala Arg Thr Phe Gly
20 25 30
Gly Gln Val Ala Ala Gln Ala Leu Val Ala Ala Thr His Thr Val Asp
35 40 45
Lys Ala Phe Thr Val His Ser Leu His Gly Tyr Phe Ile Ala Pro Gly
50 55 60
Asp Pro Thr Ala Pro Ala Ile Tyr Leu Val Asp Arg Val Arg Asp Gly
65 70 75 80
Lys Ser Tyr Val Thr Arg Ser Val Arg Gly Ile Gln Asp Gly Glu Val
85 90 95
Ile Phe Ser Met Gln Ala Ser Phe His Arg Gly Asp Glu Gly Ile Glu
100 105 110
His Met Asp Lys Met Arg Lys Val Pro Ala Pro Asp Glu Ile Lys Gly
115 120 125
Thr Val Glu Arg Met Pro Ile Ser Ser Arg Arg Val Leu Asp Glu Trp
130 135 140
Ala Glu Trp Asp Ile Arg Val Ile Pro Gln Asp Gln Leu Glu Leu Ser
145 150 155 160
Asp Phe Thr Ala Thr Glu Gln Ala Val Trp Ile Arg Cys Thr Ala Asp
165 170 175
Leu Pro Asp Asn Pro Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser
180 185 190
Asp Met Thr Leu Leu His Ser Ala Leu Val Pro His Pro Gly Glu Lys
195 200 205
Met Gln Met Ala Ser Leu Asp His Ala Val Trp Phe Leu Arg Pro Phe
210 215 220
Arg Val Asp Glu Trp Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser
225 230 235 240
Ser Gly Arg Ala Leu Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp
245 250 255
Leu Val Ala Ile Val Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu
260 265 270
Gly Ala Gln Ser Ile Pro Met Arg Lys Asp
275 280
<210> 165
<211> 510
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(487)
<223> RXN01421
<400> 165
ttgatgcacg tgcagaaatc gtcggcggtc cgtggcaccc atctgttaag ggagactcgg 60
ttactgcagg gatcctgcga gatcgagtaa acgcctaaag atg acg tcg aaa agc 115
Met Thr Ser Lys Ser
1 5
att agc ggc aag cgc ccg aat ctg ccg tcg ctc act gga gcg cgg tgg 163
Ile Ser Gly Lys Arg Pro Asn Leu Pro Ser Leu Thr Gly Ala Arg Trp
10 15 20
ctc gcg gcg ctc gct gtt tat ttt ttg cat gcg ttg gtg ttt ttg tcg 211
Leu Ala Ala Leu Ala Val Tyr Phe Leu His Ala Leu Val Phe Leu Ser
25 30 35
gtg tat ccg ttc cag cag tcg gaa ctg ttt gcc aca atc cat aaa ttt 259
Val Tyr Pro Phe Gln Gln Ser Glu Leu Phe Ala Thr Ile His Lys Phe
40 45 50
gtc ccc atg cag ctg ggt tca gct ggt gta acc ttc ttc ttt atc ttg 307
Val Pro Met Gln Leu Gly Ser Ala Gly Val Thr Phe Phe Phe Ile Leu
55 60 65
tcc gga ttt ttg atc tat tgg tca aat agc cag ctc aag ggc atg aag 355
Ser Gly Phe Leu Ile Tyr Trp Ser Asn Ser Gln Leu Lys Gly Met Lys
70 75 80 85
aat gtg ctg tat tac tgc aag cgc cgc atc acc aag att tat ccc atg 403
Asn Val Leu Tyr Tyr Cys Lys Arg Arg Ile Thr Lys Ile Tyr Pro Met
90 95 100
cac ttg att gcg ttg ccg atg ttt att gag gcg tcg gcg aag ttc acg 451
His Leu Ile Ala Leu Pro Met Phe Ile Glu Ala Ser Ala Lys Phe Thr
105 110 115
act aca ggc att acc tgg gtg ctg att ttg cgc gag taaagctgtg 497
Thr Thr Gly Ile Thr Trp Val Leu Ile Leu Arg Glu
120 125
gctgcggaat gcg 510
<210> 166
<211> 129
<212> PRT
<213> Corynebacterium glutamicum
<400> 166
Met Thr Ser Lys Ser Ile Ser Gly Lys Arg Pro Asn Leu Pro Ser Leu
1 5 10 15
Thr Gly Ala Arg Trp Leu Ala Ala Leu Ala Val Tyr Phe Leu His Ala
20 25 30
Leu Val Phe Leu Ser Val Tyr Pro Phe Gln Gln Ser Glu Leu Phe Ala
35 40 45
Thr Ile His Lys Phe Val Pro Met Gln Leu Gly Ser Ala Gly Val Thr
50 55 60
Phe Phe Phe Ile Leu Ser Gly Phe Leu Ile Tyr Trp Ser Asn Ser Gln
65 70 75 80
Leu Lys Gly Met Lys Asn Val Leu Tyr Tyr Cys Lys Arg Arg Ile Thr
85 90 95
Lys Ile Tyr Pro Met His Leu Ile Ala Leu Pro Met Phe Ile Glu Ala
100 105 110
Ser Ala Lys Phe Thr Thr Thr Gly Ile Thr Trp Val Leu Ile Leu Arg
115 120 125
Glu
<210> 167
<211> 930
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(907)
<223> RXN02342
<400> 167
caggttcgtg ctgcgtgcgg gtagttttta aaggtaaaac tttttgggcg tgtcgccctt 60
aaagcgcgct tttcgacgcg accccactac attggcttcc atg aac gtt gac att 115
Met Asn Val Asp Ile
1 5
tca cga tcc aga gag ccg cta aac gtt gag ctc ctg aag gaa aaa ttg 163
Ser Arg Ser Arg Glu Pro Leu Asn Val Glu Leu Leu Lys Glu Lys Leu
10 15 20
ctc caa aac ggt gac ttt ggc cag gtc att tac gaa aaa gtg aca ggc 211
Leu Gln Asn Gly Asp Phe Gly Gln Val Ile Tyr Glu Lys Val Thr Gly
25 30 35
tcc act aat gct gac ttg ctg gca ctt gca ggt tct ggc gct cca aac 259
Ser Thr Asn Ala Asp Leu Leu Ala Leu Ala Gly Ser Gly Ala Pro Asn
40 45 50
tgg acg gtg aaa act gtc gag ttt caa gat cat gcg cgt ggg cga ctc 307
Trp Thr Val Lys Thr Val Glu Phe Gln Asp His Ala Arg Gly Arg Leu
55 60 65
ggc cgc ccg tgg tct gcc cct gag ggt tcc caa aca atc gtg tct gtg 355
Gly Arg Pro Trp Ser Ala Pro Glu Gly Ser Gln Thr Ile Val Ser Val
70 75 80 85
ctc gtt caa cta tct att gat caa gtg gac cgg att ggc act att cca 403
Leu Val Gln Leu Ser Ile Asp Gln Val Asp Arg Ile Gly Thr Ile Pro
90 95 100
ctc gcg gcg gga ctc gct gtc atg gat gcg ttg aat gac ctc ggt gtg 451
Leu Ala Ala Gly Leu Ala Val Met Asp Ala Leu Asn Asp Leu Gly Val
105 110 115
gaa ggt gcc gga ctg aaa tgg ccc aac gat gtt caa atc cac ggc aag 499
Glu Gly Ala Gly Leu Lys Trp Pro Asn Asp Val Gln Ile His Gly Lys
120 125 130
aaa ctc tgc ggc atc ctg gtg gaa gcc acc ggc ttt gat tcc acc cca 547
Lys Leu Cys Gly Ile Leu Val Glu Ala Thr Gly Phe Asp Ser Thr Pro
135 140 145
aca gtt gtc atc ggt tgg ggc act aat atc agc ctg act aaa gag gag 595
Thr Val Val Ile Gly Trp Gly Thr Asn Ile Ser Leu Thr Lys Glu Glu
150 155 160 165
ctt cct gtt cct cat gca act tcc ctc gca ttg gaa ggt gtt gaa gtc 643
Leu Pro Val Pro His Ala Thr Ser Leu Ala Leu Glu Gly Val Glu Val
170 175 180
gac aga acc aca ttc ctt att aat atg ctc aca cat ctg cat act cga 691
Asp Arg Thr Thr Phe Leu Ile Asn Met Leu Thr His Leu His Thr Arg
185 190 195
ctg gac cag tgg cag ggt cca agt gtg gat tgg ctc gat gat tac cgt 739
Leu Asp Gln Trp Gln Gly Pro Ser Val Asp Trp Leu Asp Asp Tyr Arg
200 205 210
gcg gta tgt tcc agt att ggc caa gat gtt cga gtg ctt cta cct ggg 787
Ala Val Cys Ser Ser Ile Gly Gln Asp Val Arg Val Leu Leu Pro Gly
215 220 225
gat aaa gaa ctc tta ggt gaa gcg atc ggt gtc gcg act ggc gga gaa 835
Asp Lys Glu Leu Leu Gly Glu Ala Ile Gly Val Ala Thr Gly Gly Glu
230 235 240 245
att cgt gtt cgc gat gct tcg ggc acc gtt cac acc ctc aac gcc ggt 883
Ile Arg Val Arg Asp Ala Ser Gly Thr Val His Thr Leu Asn Ala Gly
250 255 260
gaa att acg cac ctt cgc ctg cag taaggtgacg gtatggggaa ttc 930
Glu Ile Thr His Leu Arg Leu Gln
265
<210> 168
<211> 269
<212> PRT
<213> Corynebacterium glutamicum
<400> 168
Met Asn Val Asp Ile Ser Arg Ser Arg Glu Pro Leu Asn Val Glu Leu
1 5 10 15
Leu Lys Glu Lys Leu Leu Gln Asn Gly Asp Phe Gly Gln Val Ile Tyr
20 25 30
Glu Lys Val Thr Gly Ser Thr Asn Ala Asp Leu Leu Ala Leu Ala Gly
35 40 45
Ser Gly Ala Pro Asn Trp Thr Val Lys Thr Val Glu Phe Gln Asp His
50 55 60
Ala Arg Gly Arg Leu Gly Arg Pro Trp Ser Ala Pro Glu Gly Ser Gln
65 70 75 80
Thr Ile Val Ser Val Leu Val Gln Leu Ser Ile Asp Gln Val Asp Arg
85 90 95
Ile Gly Thr Ile Pro Leu Ala Ala Gly Leu Ala Val Met Asp Ala Leu
100 105 110
Asn Asp Leu Gly Val Glu Gly Ala Gly Leu Lys Trp Pro Asn Asp Val
115 120 125
Gln Ile His Gly Lys Lys Leu Cys Gly Ile Leu Val Glu Ala Thr Gly
130 135 140
Phe Asp Ser Thr Pro Thr Val Val Ile Gly Trp Gly Thr Asn Ile Ser
145 150 155 160
Leu Thr Lys Glu Glu Leu Pro Val Pro His Ala Thr Ser Leu Ala Leu
165 170 175
Glu Gly Val Glu Val Asp Arg Thr Thr Phe Leu Ile Asn Met Leu Thr
180 185 190
His Leu His Thr Arg Leu Asp Gln Trp Gln Gly Pro Ser Val Asp Trp
195 200 205
Leu Asp Asp Tyr Arg Ala Val Cys Ser Ser Ile Gly Gln Asp Val Arg
210 215 220
Val Leu Leu Pro Gly Asp Lys Glu Leu Leu Gly Glu Ala Ile Gly Val
225 230 235 240
Ala Thr Gly Gly Glu Ile Arg Val Arg Asp Ala Ser Gly Thr Val His
245 250 255
Thr Leu Asn Ala Gly Glu Ile Thr His Leu Arg Leu Gln
260 265
<210> 169
<211> 2762
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(2739)
<223> RXN00563
<400> 169
ttc tac aag gat ctc tac gca cgt tcc gca cgc ggc acg gca gca ctg 48
Phe Tyr Lys Asp Leu Tyr Ala Arg Ser Ala Arg Gly Thr Ala Ala Leu
1 5 10 15
tgg atc gtg gcg gct aac ttg agc tcc tac tca gac atc gac gcc atc 96
Trp Ile Val Ala Ala Asn Leu Ser Ser Tyr Ser Asp Ile Asp Ala Ile
20 25 30
atc aac tgg gtc gga tcc gag cag acc acc acc gtc aac ggc gca tcc 144
Ile Asn Trp Val Gly Ser Glu Gln Thr Thr Thr Val Asn Gly Ala Ser
35 40 45
aag ctg gtc aag cca gct ttg gtc cct acc ttg ctg ttc cca ttc gcg 192
Lys Leu Val Lys Pro Ala Leu Val Pro Thr Leu Leu Phe Pro Phe Ala
50 55 60
gca cct cgc gtg tcc gga tcc atg gca gat gca ggc cca cag gca gaa 240
Ala Pro Arg Val Ser Gly Ser Met Ala Asp Ala Gly Pro Gln Ala Glu
65 70 75 80
tcc cag atg cga ctt ctg ctc tgg tct gtt gag cgc ctc atc gca ggt 288
Ser Gln Met Arg Leu Leu Leu Trp Ser Val Glu Arg Leu Ile Ala Gly
85 90 95
ctt gcg cca ttg ggc tcc tcc atc aac gtg ggt cac cgc ctg cac gtg 336
Leu Ala Pro Leu Gly Ser Ser Ile Asn Val Gly His Arg Leu His Val
100 105 110
gtc atc cca ggt tca cca aac cgt gga cgc ttc ggt ggc gat ggt gca 384
Val Ile Pro Gly Ser Pro Asn Arg Gly Arg Phe Gly Gly Asp Gly Ala
115 120 125
tac ggt gaa tcc aag gca gct ctc gac gcc gtg gtt acc cgt tgg aac 432
Tyr Gly Glu Ser Lys Ala Ala Leu Asp Ala Val Val Thr Arg Trp Asn
130 135 140
gca gag caa gct gca tgg gga gca cac acc tcc ctc gtg cac gct cac 480
Ala Glu Gln Ala Ala Trp Gly Ala His Thr Ser Leu Val His Ala His
145 150 155 160
atc ggt tgg gtt cgc ggc acc ggc ctc atg ggc ggc aac gat cct ttg 528
Ile Gly Trp Val Arg Gly Thr Gly Leu Met Gly Gly Asn Asp Pro Leu
165 170 175
gtc aag gca gct gaa gaa gca ggc gtg gaa acc tac tcc acc caa gaa 576
Val Lys Ala Ala Glu Glu Ala Gly Val Glu Thr Tyr Ser Thr Gln Glu
180 185 190
att gca gag aaa ctg ctg tcc cag gca act tcc act gtt cgc gag cag 624
Ile Ala Glu Lys Leu Leu Ser Gln Ala Thr Ser Thr Val Arg Glu Gln
195 200 205
gca gca tcc gcg cca atc acc gtc gac ttc act ggc gga ctt ggt gaa 672
Ala Ala Ser Ala Pro Ile Thr Val Asp Phe Thr Gly Gly Leu Gly Glu
210 215 220
tct gat ctg aac ctg gcg gaa atg gca cgt gca gaa gca gct aag gca 720
Ser Asp Leu Asn Leu Ala Glu Met Ala Arg Ala Glu Ala Ala Lys Ala
225 230 235 240
gct aac gca cca gtg gtt gag gct cca cgc aca gtg gca gca ctg cca 768
Ala Asn Ala Pro Val Val Glu Ala Pro Arg Thr Val Ala Ala Leu Pro
245 250 255
act cct tac cga cca gtg gtt caa acc acc cct gat ttc gca ggt caa 816
Thr Pro Tyr Arg Pro Val Val Gln Thr Thr Pro Asp Phe Ala Gly Gln
260 265 270
gtc acc caa aac ctt gac gag atg gtc gtc atc gtt ggc gcc ggc gag 864
Val Thr Gln Asn Leu Asp Glu Met Val Val Ile Val Gly Ala Gly Glu
275 280 285
ctc ggc cca ctg ggt tct gca cgt acg cgt ttc gac gcc gaa ctc aac 912
Leu Gly Pro Leu Gly Ser Ala Arg Thr Arg Phe Asp Ala Glu Leu Asn
290 295 300
ggt tcc ctc tcc gcc gcg ggt gtc atc gaa ctt gca tgg acg atg gga 960
Gly Ser Leu Ser Ala Ala Gly Val Ile Glu Leu Ala Trp Thr Met Gly
305 310 315 320
ctt atc cac tgg gat gaa gat cca aag cca ggc tgg tac gac gac tcc 1008
Leu Ile His Trp Asp Glu Asp Pro Lys Pro Gly Trp Tyr Asp Asp Ser
325 330 335
gac gac gca gtg gcc gaa gaa gac atc ttc gac cgc tac cac gac gaa 1056
Asp Asp Ala Val Ala Glu Glu Asp Ile Phe Asp Arg Tyr His Asp Glu
340 345 350
gtc atg gca cgc gtt ggt gtc cgc aag tac aat gac atg cct gag tac 1104
Val Met Ala Arg Val Gly Val Arg Lys Tyr Asn Asp Met Pro Glu Tyr
355 360 365
ggc atg atc gac aac ttt gca cca gag ctg acc acc gtc tac ctc gac 1152
Gly Met Ile Asp Asn Phe Ala Pro Glu Leu Thr Thr Val Tyr Leu Asp
370 375 380
cag gac ctc acc ttc aac gtg gga tcc cgc gaa gag gca ctg acc tac 1200
Gln Asp Leu Thr Phe Asn Val Gly Ser Arg Glu Glu Ala Leu Thr Tyr
385 390 395 400
gtc gac tcc gag cca gaa ctc acc ttt gct tct ttc gac gaa gca gca 1248
Val Asp Ser Glu Pro Glu Leu Thr Phe Ala Ser Phe Asp Glu Ala Ala
405 410 415
ggg gag tgg aag gtc act cgc aag gca ggc tcc gca atc cgc gta cct 1296
Gly Glu Trp Lys Val Thr Arg Lys Ala Gly Ser Ala Ile Arg Val Pro
420 425 430
cgc cgc atg gcg atg acc cgc ttc gtt ggt gga cag gtt cct aag gac 1344
Arg Arg Met Ala Met Thr Arg Phe Val Gly Gly Gln Val Pro Lys Asp
435 440 445
ttc gac cca gct gtg tgg ggc att cca gct gac atg gtg gac aac ctg 1392
Phe Asp Pro Ala Val Trp Gly Ile Pro Ala Asp Met Val Asp Asn Leu
450 455 460
gac acc gtc gcg ctg tgg aac att gtc tgt act gtc gac gcc ttc ctg 1440
Asp Thr Val Ala Leu Trp Asn Ile Val Cys Thr Val Asp Ala Phe Leu
465 470 475 480
tcc gct gga ttc acc cca gca gag ctg ctt gct tcc gtt cac cca gca 1488
Ser Ala Gly Phe Thr Pro Ala Glu Leu Leu Ala Ser Val His Pro Ala
485 490 495
cgc gtg tcc tct acc caa ggc acc ggc atg ggc ggc atg gaa tcc ctc 1536
Arg Val Ser Ser Thr Gln Gly Thr Gly Met Gly Gly Met Glu Ser Leu
500 505 510
cgt ggc atc tac gtc gac cgc att ctg gca gag cca cgc gcc aac gac 1584
Arg Gly Ile Tyr Val Asp Arg Ile Leu Ala Glu Pro Arg Ala Asn Asp
515 520 525
gtt ctg cag gaa gca ctg ccc aac gtt gtt gca gct cac gtc atg cag 1632
Val Leu Gln Glu Ala Leu Pro Asn Val Val Ala Ala His Val Met Gln
530 535 540
tcc tac gtc ggt ggc tac gga cag atg atc cac cca gtc gca gct tgt 1680
Ser Tyr Val Gly Gly Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys
545 550 555 560
gca acc gca gct gtt tct gtg gaa gaa gca ctg gac aag atc cgc atc 1728
Ala Thr Ala Ala Val Ser Val Glu Glu Ala Leu Asp Lys Ile Arg Ile
565 570 575
ggc aag tcc gac ttc gtt gtc gca ggt ggc ttc gat gcc ctg tcc gtt 1776
Gly Lys Ser Asp Phe Val Val Ala Gly Gly Phe Asp Ala Leu Ser Val
580 585 590
gaa ggc atc acc ggc ttc ggc gac atg gca gca acc gcc gac tcc gca 1824
Glu Gly Ile Thr Gly Phe Gly Asp Met Ala Ala Thr Ala Asp Ser Ala
595 600 605
gag atg gaa ggc aag gga att gag cac cgc ttc ttc tcc cgc gcc aac 1872
Glu Met Glu Gly Lys Gly Ile Glu His Arg Phe Phe Ser Arg Ala Asn
610 615 620
gac cgg cgc cgc ggt gga ttc atc gaa tcc gaa ggt ggc gga acc gtc 1920
Asp Arg Arg Arg Gly Gly Phe Ile Glu Ser Glu Gly Gly Gly Thr Val
625 630 635 640
ctt ctg gca cgc gga tca ctc gca gct gac ctg ggc ctt cca gta ctc 1968
Leu Leu Ala Arg Gly Ser Leu Ala Ala Asp Leu Gly Leu Pro Val Leu
645 650 655
ggt gtc atc gga ttc gca gag tcc ttt gca gat ggt gcc cac acc tcc 2016
Gly Val Ile Gly Phe Ala Glu Ser Phe Ala Asp Gly Ala His Thr Ser
660 665 670
atc cca gcc cca ggc ctc ggt gcc ctt ggt gct gct cgc gat ggt gtg 2064
Ile Pro Ala Pro Gly Leu Gly Ala Leu Gly Ala Ala Arg Asp Gly Val
675 680 685
gaa tct cgc ctt gca gta gca ctg cgt tcc gtc ggt gtc tct gct gat 2112
Glu Ser Arg Leu Ala Val Ala Leu Arg Ser Val Gly Val Ser Ala Asp
690 695 700
gag atc tcc att atc tcc aag cac gac acc tcc acc aac gcg aat gat 2160
Glu Ile Ser Ile Ile Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp
705 710 715 720
cca aac gag tcc gac ctg cac gag cgc atc gca tcc gct atc ggt cgt 2208
Pro Asn Glu Ser Asp Leu His Glu Arg Ile Ala Ser Ala Ile Gly Arg
725 730 735
gca gac ggc aac ccg atg tac gtg att tcc cag aag tca ctc acc gga 2256
Ala Asp Gly Asn Pro Met Tyr Val Ile Ser Gln Lys Ser Leu Thr Gly
740 745 750
cac gcc aag ggt ggt gca gca gca ttc cag atg atc ggt ctc acc cag 2304
His Ala Lys Gly Gly Ala Ala Ala Phe Gln Met Ile Gly Leu Thr Gln
755 760 765
gtc ctc cga tcc gga ctg gtg cca gcc aac cgc gca ctc gac tgc gtt 2352
Val Leu Arg Ser Gly Leu Val Pro Ala Asn Arg Ala Leu Asp Cys Val
770 775 780
gac cca gta ctg tcc aag cat tcc cac ctc gtc tgg ctg cgc aag cca 2400
Asp Pro Val Leu Ser Lys His Ser His Leu Val Trp Leu Arg Lys Pro
785 790 795 800
cta gac ctt cgt gcg aag gca cca aag gca ggt ctt gtt acc tcc ctt 2448
Leu Asp Leu Arg Ala Lys Ala Pro Lys Ala Gly Leu Val Thr Ser Leu
805 810 815
ggc ttc gga cac gtc tcc gct ctg gtt gcg att gtt cac cca gac gcc 2496
Gly Phe Gly His Val Ser Ala Leu Val Ala Ile Val His Pro Asp Ala
820 825 830
ttc tat gag gca gtt cgt gtg gca cgt ggt gct gag gca gct gac gta 2544
Phe Tyr Glu Ala Val Arg Val Ala Arg Gly Ala Glu Ala Ala Asp Val
835 840 845
tgg cgc gca tcc gcg atc gct cgc gaa gaa gca ggc ctt cgt acc atc 2592
Trp Arg Ala Ser Ala Ile Ala Arg Glu Glu Ala Gly Leu Arg Thr Ile
850 855 860
gtc gcc ggt atg cac ggt ggc gta ctg tac gaa cgc cca gtc gag cgc 2640
Val Ala Gly Met His Gly Gly Val Leu Tyr Glu Arg Pro Val Glu Arg
865 870 875 880
aac ctc ggt gtc cac gga gac gca gct aag gaa gtt gaa gct gca gtc 2688
Asn Leu Gly Val His Gly Asp Ala Ala Lys Glu Val Glu Ala Ala Val
885 890 895
ctc ctg gat tcc cgc gcc cgc cta gtt gac ggt gtc ctc cgc gcc gaa 2736
Leu Leu Asp Ser Arg Ala Arg Leu Val Asp Gly Val Leu Arg Ala Glu
900 905 910
ggc tagttggtta ttgcgttgag ccc 2762
Gly
<210> 170
<211> 913
<212> PRT
<213> Corynebacterium glutamicum
<400> 170
Phe Tyr Lys Asp Leu Tyr Ala Arg Ser Ala Arg Gly Thr Ala Ala Leu
1 5 10 15
Trp Ile Val Ala Ala Asn Leu Ser Ser Tyr Ser Asp Ile Asp Ala Ile
20 25 30
Ile Asn Trp Val Gly Ser Glu Gln Thr Thr Thr Val Asn Gly Ala Ser
35 40 45
Lys Leu Val Lys Pro Ala Leu Val Pro Thr Leu Leu Phe Pro Phe Ala
50 55 60
Ala Pro Arg Val Ser Gly Ser Met Ala Asp Ala Gly Pro Gln Ala Glu
65 70 75 80
Ser Gln Met Arg Leu Leu Leu Trp Ser Val Glu Arg Leu Ile Ala Gly
85 90 95
Leu Ala Pro Leu Gly Ser Ser Ile Asn Val Gly His Arg Leu His Val
100 105 110
Val Ile Pro Gly Ser Pro Asn Arg Gly Arg Phe Gly Gly Asp Gly Ala
115 120 125
Tyr Gly Glu Ser Lys Ala Ala Leu Asp Ala Val Val Thr Arg Trp Asn
130 135 140
Ala Glu Gln Ala Ala Trp Gly Ala His Thr Ser Leu Val His Ala His
145 150 155 160
Ile Gly Trp Val Arg Gly Thr Gly Leu Met Gly Gly Asn Asp Pro Leu
165 170 175
Val Lys Ala Ala Glu Glu Ala Gly Val Glu Thr Tyr Ser Thr Gln Glu
180 185 190
Ile Ala Glu Lys Leu Leu Ser Gln Ala Thr Ser Thr Val Arg Glu Gln
195 200 205
Ala Ala Ser Ala Pro Ile Thr Val Asp Phe Thr Gly Gly Leu Gly Glu
210 215 220
Ser Asp Leu Asn Leu Ala Glu Met Ala Arg Ala Glu Ala Ala Lys Ala
225 230 235 240
Ala Asn Ala Pro Val Val Glu Ala Pro Arg Thr Val Ala Ala Leu Pro
245 250 255
Thr Pro Tyr Arg Pro Val Val Gln Thr Thr Pro Asp Phe Ala Gly Gln
260 265 270
Val Thr Gln Asn Leu Asp Glu Met Val Val Ile Val Gly Ala Gly Glu
275 280 285
Leu Gly Pro Leu Gly Ser Ala Arg Thr Arg Phe Asp Ala Glu Leu Asn
290 295 300
Gly Ser Leu Ser Ala Ala Gly Val Ile Glu Leu Ala Trp Thr Met Gly
305 310 315 320
Leu Ile His Trp Asp Glu Asp Pro Lys Pro Gly Trp Tyr Asp Asp Ser
325 330 335
Asp Asp Ala Val Ala Glu Glu Asp Ile Phe Asp Arg Tyr His Asp Glu
340 345 350
Val Met Ala Arg Val Gly Val Arg Lys Tyr Asn Asp Met Pro Glu Tyr
355 360 365
Gly Met Ile Asp Asn Phe Ala Pro Glu Leu Thr Thr Val Tyr Leu Asp
370 375 380
Gln Asp Leu Thr Phe Asn Val Gly Ser Arg Glu Glu Ala Leu Thr Tyr
385 390 395 400
Val Asp Ser Glu Pro Glu Leu Thr Phe Ala Ser Phe Asp Glu Ala Ala
405 410 415
Gly Glu Trp Lys Val Thr Arg Lys Ala Gly Ser Ala Ile Arg Val Pro
420 425 430
Arg Arg Met Ala Met Thr Arg Phe Val Gly Gly Gln Val Pro Lys Asp
435 440 445
Phe Asp Pro Ala Val Trp Gly Ile Pro Ala Asp Met Val Asp Asn Leu
450 455 460
Asp Thr Val Ala Leu Trp Asn Ile Val Cys Thr Val Asp Ala Phe Leu
465 470 475 480
Ser Ala Gly Phe Thr Pro Ala Glu Leu Leu Ala Ser Val His Pro Ala
485 490 495
Arg Val Ser Ser Thr Gln Gly Thr Gly Met Gly Gly Met Glu Ser Leu
500 505 510
Arg Gly Ile Tyr Val Asp Arg Ile Leu Ala Glu Pro Arg Ala Asn Asp
515 520 525
Val Leu Gln Glu Ala Leu Pro Asn Val Val Ala Ala His Val Met Gln
530 535 540
Ser Tyr Val Gly Gly Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys
545 550 555 560
Ala Thr Ala Ala Val Ser Val Glu Glu Ala Leu Asp Lys Ile Arg Ile
565 570 575
Gly Lys Ser Asp Phe Val Val Ala Gly Gly Phe Asp Ala Leu Ser Val
580 585 590
Glu Gly Ile Thr Gly Phe Gly Asp Met Ala Ala Thr Ala Asp Ser Ala
595 600 605
Glu Met Glu Gly Lys Gly Ile Glu His Arg Phe Phe Ser Arg Ala Asn
610 615 620
Asp Arg Arg Arg Gly Gly Phe Ile Glu Ser Glu Gly Gly Gly Thr Val
625 630 635 640
Leu Leu Ala Arg Gly Ser Leu Ala Ala Asp Leu Gly Leu Pro Val Leu
645 650 655
Gly Val Ile Gly Phe Ala Glu Ser Phe Ala Asp Gly Ala His Thr Ser
660 665 670
Ile Pro Ala Pro Gly Leu Gly Ala Leu Gly Ala Ala Arg Asp Gly Val
675 680 685
Glu Ser Arg Leu Ala Val Ala Leu Arg Ser Val Gly Val Ser Ala Asp
690 695 700
Glu Ile Ser Ile Ile Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp
705 710 715 720
Pro Asn Glu Ser Asp Leu His Glu Arg Ile Ala Ser Ala Ile Gly Arg
725 730 735
Ala Asp Gly Asn Pro Met Tyr Val Ile Ser Gln Lys Ser Leu Thr Gly
740 745 750
His Ala Lys Gly Gly Ala Ala Ala Phe Gln Met Ile Gly Leu Thr Gln
755 760 765
Val Leu Arg Ser Gly Leu Val Pro Ala Asn Arg Ala Leu Asp Cys Val
770 775 780
Asp Pro Val Leu Ser Lys His Ser His Leu Val Trp Leu Arg Lys Pro
785 790 795 800
Leu Asp Leu Arg Ala Lys Ala Pro Lys Ala Gly Leu Val Thr Ser Leu
805 810 815
Gly Phe Gly His Val Ser Ala Leu Val Ala Ile Val His Pro Asp Ala
820 825 830
Phe Tyr Glu Ala Val Arg Val Ala Arg Gly Ala Glu Ala Ala Asp Val
835 840 845
Trp Arg Ala Ser Ala Ile Ala Arg Glu Glu Ala Gly Leu Arg Thr Ile
850 855 860
Val Ala Gly Met His Gly Gly Val Leu Tyr Glu Arg Pro Val Glu Arg
865 870 875 880
Asn Leu Gly Val His Gly Asp Ala Ala Lys Glu Val Glu Ala Ala Val
885 890 895
Leu Leu Asp Ser Arg Ala Arg Leu Val Asp Gly Val Leu Arg Ala Glu
900 905 910
Gly
<210> 171
<211> 2937
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(2914)
<223> RXN02168
<400> 171
agggtttagt catctatttc ggctacgctc acgtaaccta cgcattcgta agtggtcatg 60
ggtccaagaa gcccattcca agacttagga gctttatttc gtg agt att tct tca 115
Val Ser Ile Ser Ser
1 5
ctg aca ccg ctg cac tct ttc aaa gag cca gca att ctg tac gcc ggt 163
Leu Thr Pro Leu His Ser Phe Lys Glu Pro Ala Ile Leu Tyr Ala Gly
10 15 20
cag gct tct gcc tgg cag cag gtg atc gct gat tcc agc gaa gac cac 211
Gln Ala Ser Ala Trp Gln Gln Val Ile Ala Asp Ser Ser Glu Asp His
25 30 35
atc acc gca acg cac ctg cgc gag ctc ctg tct cgc tcc cgt gca aag 259
Ile Thr Ala Thr His Leu Arg Glu Leu Leu Ser Arg Ser Arg Ala Lys
40 45 50
act gca cct ttc gct cgc caa atc acc gcc atc gtg cct ggc tca ctt 307
Thr Ala Pro Phe Ala Arg Gln Ile Thr Ala Ile Val Pro Gly Ser Leu
55 60 65
gct cgt ctt gag gaa ctg acc cgc gaa gac gca caa atc ggt gca gac 355
Ala Arg Leu Glu Glu Leu Thr Arg Glu Asp Ala Gln Ile Gly Ala Asp
70 75 80 85
atc gac gca cag cct gcc gtt tcc att cca ggc att ctg ctg gga cag 403
Ile Asp Ala Gln Pro Ala Val Ser Ile Pro Gly Ile Leu Leu Gly Gln
90 95 100
atc gct gca acc cgt cag ctg cgt gac ctc gga ctc gat gtc gca gca 451
Ile Ala Ala Thr Arg Gln Leu Arg Asp Leu Gly Leu Asp Val Ala Ala
105 110 115
gct tcc cgc ctt gga cac tcc cag ggc att ttg ggc gtt gaa gca gta 499
Ala Ser Arg Leu Gly His Ser Gln Gly Ile Leu Gly Val Glu Ala Val
120 125 130
gac aat gaa gaa gac gtt tta gct ttc gcc atc ctg ctg ggc gca gca 547
Asp Asn Glu Glu Asp Val Leu Ala Phe Ala Ile Leu Leu Gly Ala Ala
135 140 145
gct tcc cag ttc gct ggc aag ggc gca cat atg ctc tct gtt cgc ggc 595
Ala Ser Gln Phe Ala Gly Lys Gly Ala His Met Leu Ser Val Arg Gly
150 155 160 165
ctg tcc cgt gag atc atc cag gac acc atc gct ggt gtc gat ggg gta 643
Leu Ser Arg Glu Ile Ile Gln Asp Thr Ile Ala Gly Val Asp Gly Val
170 175 180
gag gtc tcc ctg cgc aac gct cgt gca cac ttt gtt gtc tct ggt aag 691
Glu Val Ser Leu Arg Asn Ala Arg Ala His Phe Val Val Ser Gly Lys
185 190 195
cca gag gca ctg aag aag gct gct gct gct cta cag cgc gca gct gat 739
Pro Glu Ala Leu Lys Lys Ala Ala Ala Ala Leu Gln Arg Ala Ala Asp
200 205 210
gtt tac aac gaa gac atc aac gaa aag cgc aag ggt gga tcc ctg gca 787
Val Tyr Asn Glu Asp Ile Asn Glu Lys Arg Lys Gly Gly Ser Leu Ala
215 220 225
gag cct aag ttt gac tac ttg gat gtg gcc att cct ttc cac cac tcc 835
Glu Pro Lys Phe Asp Tyr Leu Asp Val Ala Ile Pro Phe His His Ser
230 235 240 245
tcc atg cag gac gca gcc gac ttg gct gtc gag tgg gca acc acc tgt 883
Ser Met Gln Asp Ala Ala Asp Leu Ala Val Glu Trp Ala Thr Thr Cys
250 255 260
ggc cta aac gtc aac gcg cgc gcg ttg gca gaa gca att cta gtt aac 931
Gly Leu Asn Val Asn Ala Arg Ala Leu Ala Glu Ala Ile Leu Val Asn
265 270 275
cca gct gac tgg gtt gag cag atc gca aac ctc aag gct gat tac gtt 979
Pro Ala Asp Trp Val Glu Gln Ile Ala Asn Leu Lys Ala Asp Tyr Val
280 285 290
ctt tcc ctc gat gca ggc gtc agc cgt ttc acc gct cca ttg cta gac 1027
Leu Ser Leu Asp Ala Gly Val Ser Arg Phe Thr Ala Pro Leu Leu Asp
295 300 305
ggt cgc gga atc tct ttg gtt cct gcg ttc tcc gct gca gag cgc gac 1075
Gly Arg Gly Ile Ser Leu Val Pro Ala Phe Ser Ala Ala Glu Arg Asp
310 315 320 325
aac ttg gct cgc cct ggc ttc cac gtt cct acc gct gag gat tgg tcc 1123
Asn Leu Ala Arg Pro Gly Phe His Val Pro Thr Ala Glu Asp Trp Ser
330 335 340
gag ttc gct cca aag ctg gtt aag ctt cca aac ggt gag cac aag gtt 1171
Glu Phe Ala Pro Lys Leu Val Lys Leu Pro Asn Gly Glu His Lys Val
345 350 355
ctc acc ggg ttc tcc cgc ctg act ggt tat tcc cca atc gtc ctg gct 1219
Leu Thr Gly Phe Ser Arg Leu Thr Gly Tyr Ser Pro Ile Val Leu Ala
360 365 370
ggc atg acc cca acc acc gtt gat cct gag atc gtt gca gct gca gcg 1267
Gly Met Thr Pro Thr Thr Val Asp Pro Glu Ile Val Ala Ala Ala Ala
375 380 385
aac gct gga cac tgg gcc gaa atg gcc ggt ggc gga cag tac tct gaa 1315
Asn Ala Gly His Trp Ala Glu Met Ala Gly Gly Gly Gln Tyr Ser Glu
390 395 400 405
gaa gtc ttc acc aag aac aag gaa aag ctc gtt tcc ctg ctc aag gtt 1363
Glu Val Phe Thr Lys Asn Lys Glu Lys Leu Val Ser Leu Leu Lys Val
410 415 420
gga cgc tcc gca cag ttc aac tcc atg ttc ttc gac cgc tac atg tgg 1411
Gly Arg Ser Ala Gln Phe Asn Ser Met Phe Phe Asp Arg Tyr Met Trp
425 430 435
aac ctg cag ttc ggt gca cag cgc atc gtt tcc aag gca cgt gca acc 1459
Asn Leu Gln Phe Gly Ala Gln Arg Ile Val Ser Lys Ala Arg Ala Thr
440 445 450
ggt acc tcc atc aac ggt gtt gtt gtc tcc gct ggt atc cca gag gtt 1507
Gly Thr Ser Ile Asn Gly Val Val Val Ser Ala Gly Ile Pro Glu Val
455 460 465
gag gaa gca act gag ctg atc aac gat ctg aac gct gat ggc ttc cca 1555
Glu Glu Ala Thr Glu Leu Ile Asn Asp Leu Asn Ala Asp Gly Phe Pro
470 475 480 485
tac gtt gca ttc aag cca ggc acc gtg gat cag atc cgc gca acc ctg 1603
Tyr Val Ala Phe Lys Pro Gly Thr Val Asp Gln Ile Arg Ala Thr Leu
490 495 500
aag att gct gat gca aac cca gag acc aag atc atc atc cag atc gag 1651
Lys Ile Ala Asp Ala Asn Pro Glu Thr Lys Ile Ile Ile Gln Ile Glu
505 510 515
gac gga cac gct ggt ggc cac cac tcc tgg gtc aac ttg gac gat ctg 1699
Asp Gly His Ala Gly Gly His His Ser Trp Val Asn Leu Asp Asp Leu
520 525 530
ctc ctg acc acc tac gca gag ctg cgt tcc cgc aag aac gtt gtc gtc 1747
Leu Leu Thr Thr Tyr Ala Glu Leu Arg Ser Arg Lys Asn Val Val Val
535 540 545
atg atc ggt ggc ggc atc gga acc cct gca aag gct gct tac tac ctg 1795
Met Ile Gly Gly Gly Ile Gly Thr Pro Ala Lys Ala Ala Tyr Tyr Leu
550 555 560 565
acc ggt gaa tgg tcc acc gat ttg ggc ttc cca gca atg cca gtg gac 1843
Thr Gly Glu Trp Ser Thr Asp Leu Gly Phe Pro Ala Met Pro Val Asp
570 575 580
ggc atc ctc gtg ggt acc gct gcc atg gca acc aag gaa gca acc act 1891
Gly Ile Leu Val Gly Thr Ala Ala Met Ala Thr Lys Glu Ala Thr Thr
585 590 595
tct cct cag gtc aag cag gca ctg gtc gac acc cca ggt gtt gat cca 1939
Ser Pro Gln Val Lys Gln Ala Leu Val Asp Thr Pro Gly Val Asp Pro
600 605 610
cac gac gct ggc ggc tgg gtt ggc cgt ggc gat gct cgt ggt ggc gtg 1987
His Asp Ala Gly Gly Trp Val Gly Arg Gly Asp Ala Arg Gly Gly Val
615 620 625
acc tct ggt ctg tca cac ctg cac gct gac atg tac gag ctg gac aac 2035
Thr Ser Gly Leu Ser His Leu His Ala Asp Met Tyr Glu Leu Asp Asn
630 635 640 645
gat tct gct gca gct tcc cgc ctg atc tct tcc atc gat tct gat gat 2083
Asp Ser Ala Ala Ala Ser Arg Leu Ile Ser Ser Ile Asp Ser Asp Asp
650 655 660
tac gca gat cac cgc gaa gag ctc atc gag gct atc aac aag acc gct 2131
Tyr Ala Asp His Arg Glu Glu Leu Ile Glu Ala Ile Asn Lys Thr Ala
665 670 675
aag cct ttc ttc ggc gag gtc gaa gag atg act tac gca gag tgg atc 2179
Lys Pro Phe Phe Gly Glu Val Glu Glu Met Thr Tyr Ala Glu Trp Ile
680 685 690
cag cgt tgg gtt gag ctt gct tac cca act cag gac cca acc tgg gat 2227
Gln Arg Trp Val Glu Leu Ala Tyr Pro Thr Gln Asp Pro Thr Trp Asp
695 700 705
gat cgt ttc ctc gat ttg gtt cac cgc att gaa gct cgt ctc aac gag 2275
Asp Arg Phe Leu Asp Leu Val His Arg Ile Glu Ala Arg Leu Asn Glu
710 715 720 725
gca gag cac ggc gcc atc acc aca ctg ttc cca gac cat gcg tct gtg 2323
Ala Glu His Gly Ala Ile Thr Thr Leu Phe Pro Asp His Ala Ser Val
730 735 740
gaa aat gag gaa gag gcc gtc gaa aag ctt ctt gct gct tac ccg cag 2371
Glu Asn Glu Glu Glu Ala Val Glu Lys Leu Leu Ala Ala Tyr Pro Gln
745 750 755
gcc cgc gag atc cag gtc tct gcg cgc gac gcc gcg tgg ttt att ggt 2419
Ala Arg Glu Ile Gln Val Ser Ala Arg Asp Ala Ala Trp Phe Ile Gly
760 765 770
ctg tgc cgc aag cac cac aag cct atg cct tgg gtt cca gca atc gat 2467
Leu Cys Arg Lys His His Lys Pro Met Pro Trp Val Pro Ala Ile Asp
775 780 785
gct gac cta gca cgc tgg tgg ggc ctt gac acc ctg tgg cag tcc cag 2515
Ala Asp Leu Ala Arg Trp Trp Gly Leu Asp Thr Leu Trp Gln Ser Gln
790 795 800 805
aac gag cgc tac ggc gcg aac tca gtc cgc gtt atc cca gga cca gtc 2563
Asn Glu Arg Tyr Gly Ala Asn Ser Val Arg Val Ile Pro Gly Pro Val
810 815 820
tcc gtc gcc ggc atc gac cgt gtt gac gag cca gtt gca gag ctg ctc 2611
Ser Val Ala Gly Ile Asp Arg Val Asp Glu Pro Val Ala Glu Leu Leu
825 830 835
ggc cgc ttc gaa gct gcc tgc gtt gac gct ctc gac ggc gag cca gaa 2659
Gly Arg Phe Glu Ala Ala Cys Val Asp Ala Leu Asp Gly Glu Pro Glu
840 845 850
gag atc ttc gct cgc ctc aat gag tcc aag aac gag cgc gaa ttc ctg 2707
Glu Ile Phe Ala Arg Leu Asn Glu Ser Lys Asn Glu Arg Glu Phe Leu
855 860 865
ctg gct acc cca cac atc gtg tgg cac ggc aac ctg atc gac aac cca 2755
Leu Ala Thr Pro His Ile Val Trp His Gly Asn Leu Ile Asp Asn Pro
870 875 880 885
gct cac gtc ctc aac gag ggt gct ttc gag ctc atc gag gag gat ggc 2803
Ala His Val Leu Asn Glu Gly Ala Phe Glu Leu Ile Glu Glu Asp Gly
890 895 900
tac tgg gtc atc cgt atc ctg gct gat tcc tac ttc gac gat ctg cca 2851
Tyr Trp Val Ile Arg Ile Leu Ala Asp Ser Tyr Phe Asp Asp Leu Pro
905 910 915
gtt gag cag cgc cca tac ctg gtt cag cat gtt gac atc cca gtt gag 2899
Val Glu Gln Arg Pro Tyr Leu Val Gln His Val Asp Ile Pro Val Glu
920 925 930
ctg ggt gac gct ggt tgaaccggtg gtttcccaat tgg 2937
Leu Gly Asp Ala Gly
935
<210> 172
<211> 938
<212> PRT
<213> Corynebacterium glutamicum
<400> 172
Val Ser Ile Ser Ser Leu Thr Pro Leu His Ser Phe Lys Glu Pro Ala
1 5 10 15
Ile Leu Tyr Ala Gly Gln Ala Ser Ala Trp Gln Gln Val Ile Ala Asp
20 25 30
Ser Ser Glu Asp His Ile Thr Ala Thr His Leu Arg Glu Leu Leu Ser
35 40 45
Arg Ser Arg Ala Lys Thr Ala Pro Phe Ala Arg Gln Ile Thr Ala Ile
50 55 60
Val Pro Gly Ser Leu Ala Arg Leu Glu Glu Leu Thr Arg Glu Asp Ala
65 70 75 80
Gln Ile Gly Ala Asp Ile Asp Ala Gln Pro Ala Val Ser Ile Pro Gly
85 90 95
Ile Leu Leu Gly Gln Ile Ala Ala Thr Arg Gln Leu Arg Asp Leu Gly
100 105 110
Leu Asp Val Ala Ala Ala Ser Arg Leu Gly His Ser Gln Gly Ile Leu
115 120 125
Gly Val Glu Ala Val Asp Asn Glu Glu Asp Val Leu Ala Phe Ala Ile
130 135 140
Leu Leu Gly Ala Ala Ala Ser Gln Phe Ala Gly Lys Gly Ala His Met
145 150 155 160
Leu Ser Val Arg Gly Leu Ser Arg Glu Ile Ile Gln Asp Thr Ile Ala
165 170 175
Gly Val Asp Gly Val Glu Val Ser Leu Arg Asn Ala Arg Ala His Phe
180 185 190
Val Val Ser Gly Lys Pro Glu Ala Leu Lys Lys Ala Ala Ala Ala Leu
195 200 205
Gln Arg Ala Ala Asp Val Tyr Asn Glu Asp Ile Asn Glu Lys Arg Lys
210 215 220
Gly Gly Ser Leu Ala Glu Pro Lys Phe Asp Tyr Leu Asp Val Ala Ile
225 230 235 240
Pro Phe His His Ser Ser Met Gln Asp Ala Ala Asp Leu Ala Val Glu
245 250 255
Trp Ala Thr Thr Cys Gly Leu Asn Val Asn Ala Arg Ala Leu Ala Glu
260 265 270
Ala Ile Leu Val Asn Pro Ala Asp Trp Val Glu Gln Ile Ala Asn Leu
275 280 285
Lys Ala Asp Tyr Val Leu Ser Leu Asp Ala Gly Val Ser Arg Phe Thr
290 295 300
Ala Pro Leu Leu Asp Gly Arg Gly Ile Ser Leu Val Pro Ala Phe Ser
305 310 315 320
Ala Ala Glu Arg Asp Asn Leu Ala Arg Pro Gly Phe His Val Pro Thr
325 330 335
Ala Glu Asp Trp Ser Glu Phe Ala Pro Lys Leu Val Lys Leu Pro Asn
340 345 350
Gly Glu His Lys Val Leu Thr Gly Phe Ser Arg Leu Thr Gly Tyr Ser
355 360 365
Pro Ile Val Leu Ala Gly Met Thr Pro Thr Thr Val Asp Pro Glu Ile
370 375 380
Val Ala Ala Ala Ala Asn Ala Gly His Trp Ala Glu Met Ala Gly Gly
385 390 395 400
Gly Gln Tyr Ser Glu Glu Val Phe Thr Lys Asn Lys Glu Lys Leu Val
405 410 415
Ser Leu Leu Lys Val Gly Arg Ser Ala Gln Phe Asn Ser Met Phe Phe
420 425 430
Asp Arg Tyr Met Trp Asn Leu Gln Phe Gly Ala Gln Arg Ile Val Ser
435 440 445
Lys Ala Arg Ala Thr Gly Thr Ser Ile Asn Gly Val Val Val Ser Ala
450 455 460
Gly Ile Pro Glu Val Glu Glu Ala Thr Glu Leu Ile Asn Asp Leu Asn
465 470 475 480
Ala Asp Gly Phe Pro Tyr Val Ala Phe Lys Pro Gly Thr Val Asp Gln
485 490 495
Ile Arg Ala Thr Leu Lys Ile Ala Asp Ala Asn Pro Glu Thr Lys Ile
500 505 510
Ile Ile Gln Ile Glu Asp Gly His Ala Gly Gly His His Ser Trp Val
515 520 525
Asn Leu Asp Asp Leu Leu Leu Thr Thr Tyr Ala Glu Leu Arg Ser Arg
530 535 540
Lys Asn Val Val Val Met Ile Gly Gly Gly Ile Gly Thr Pro Ala Lys
545 550 555 560
Ala Ala Tyr Tyr Leu Thr Gly Glu Trp Ser Thr Asp Leu Gly Phe Pro
565 570 575
Ala Met Pro Val Asp Gly Ile Leu Val Gly Thr Ala Ala Met Ala Thr
580 585 590
Lys Glu Ala Thr Thr Ser Pro Gln Val Lys Gln Ala Leu Val Asp Thr
595 600 605
Pro Gly Val Asp Pro His Asp Ala Gly Gly Trp Val Gly Arg Gly Asp
610 615 620
Ala Arg Gly Gly Val Thr Ser Gly Leu Ser His Leu His Ala Asp Met
625 630 635 640
Tyr Glu Leu Asp Asn Asp Ser Ala Ala Ala Ser Arg Leu Ile Ser Ser
645 650 655
Ile Asp Ser Asp Asp Tyr Ala Asp His Arg Glu Glu Leu Ile Glu Ala
660 665 670
Ile Asn Lys Thr Ala Lys Pro Phe Phe Gly Glu Val Glu Glu Met Thr
675 680 685
Tyr Ala Glu Trp Ile Gln Arg Trp Val Glu Leu Ala Tyr Pro Thr Gln
690 695 700
Asp Pro Thr Trp Asp Asp Arg Phe Leu Asp Leu Val His Arg Ile Glu
705 710 715 720
Ala Arg Leu Asn Glu Ala Glu His Gly Ala Ile Thr Thr Leu Phe Pro
725 730 735
Asp His Ala Ser Val Glu Asn Glu Glu Glu Ala Val Glu Lys Leu Leu
740 745 750
Ala Ala Tyr Pro Gln Ala Arg Glu Ile Gln Val Ser Ala Arg Asp Ala
755 760 765
Ala Trp Phe Ile Gly Leu Cys Arg Lys His His Lys Pro Met Pro Trp
770 775 780
Val Pro Ala Ile Asp Ala Asp Leu Ala Arg Trp Trp Gly Leu Asp Thr
785 790 795 800
Leu Trp Gln Ser Gln Asn Glu Arg Tyr Gly Ala Asn Ser Val Arg Val
805 810 815
Ile Pro Gly Pro Val Ser Val Ala Gly Ile Asp Arg Val Asp Glu Pro
820 825 830
Val Ala Glu Leu Leu Gly Arg Phe Glu Ala Ala Cys Val Asp Ala Leu
835 840 845
Asp Gly Glu Pro Glu Glu Ile Phe Ala Arg Leu Asn Glu Ser Lys Asn
850 855 860
Glu Arg Glu Phe Leu Leu Ala Thr Pro His Ile Val Trp His Gly Asn
865 870 875 880
Leu Ile Asp Asn Pro Ala His Val Leu Asn Glu Gly Ala Phe Glu Leu
885 890 895
Ile Glu Glu Asp Gly Tyr Trp Val Ile Arg Ile Leu Ala Asp Ser Tyr
900 905 910
Phe Asp Asp Leu Pro Val Glu Gln Arg Pro Tyr Leu Val Gln His Val
915 920 925
Asp Ile Pro Val Glu Leu Gly Asp Ala Gly
930 935
<210> 173
<211> 921
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(898)
<223> RXN01090
<400> 173
gccggtttgg gctggttgga gctctagatc gtaagtggtg tcgtacccat gacgtaccat 60
taaccacgaa cgttttaaag aagccacgaa ggagcctgac atg gcg tta cca cta 115
Met Ala Leu Pro Leu
1 5
ccc agc aag agc gct cga gca ctt gtt act ggg gca agc caa ggc att 163
Pro Ser Lys Ser Ala Arg Ala Leu Val Thr Gly Ala Ser Gln Gly Ile
10 15 20
ggc ctc gcc atc gcc aaa gat ttg gcg cgg tat ggg cac aac ctc att 211
Gly Leu Ala Ile Ala Lys Asp Leu Ala Arg Tyr Gly His Asn Leu Ile
25 30 35
ttg gtt gct cgc cgc gag gat gtc ctc aaa gag atc gcc gca gat cta 259
Leu Val Ala Arg Arg Glu Asp Val Leu Lys Glu Ile Ala Ala Asp Leu
40 45 50
gag aag aag cac ggc gtg atc gtt gag gtc cgc ccg gtg gat ttg agt 307
Glu Lys Lys His Gly Val Ile Val Glu Val Arg Pro Val Asp Leu Ser
55 60 65
gat gag cca gcc cgc aag gtg ttg atc gat gag atc aag aca agg gaa 355
Asp Glu Pro Ala Arg Lys Val Leu Ile Asp Glu Ile Lys Thr Arg Glu
70 75 80 85
atc aac atc atc att aac tct gct ggc atc gca agc ttt ggg ccg ttc 403
Ile Asn Ile Ile Ile Asn Ser Ala Gly Ile Ala Ser Phe Gly Pro Phe
90 95 100
aag gac cag gat tgg tct tat gag act gcc cag ttc tca ctt aat gcc 451
Lys Asp Gln Asp Trp Ser Tyr Glu Thr Ala Gln Phe Ser Leu Asn Ala
105 110 115
aca gcc gtt ttt gag ctc acc cac gcg gtg ttg ggt ggc atg att gac 499
Thr Ala Val Phe Glu Leu Thr His Ala Val Leu Gly Gly Met Ile Asp
120 125 130
cgt ggc acg ggc gct att tgc aat gtg gga tct gcg gct ggc aat gtg 547
Arg Gly Thr Gly Ala Ile Cys Asn Val Gly Ser Ala Ala Gly Asn Val
135 140 145
cca atc ccc aac aac gcc acg tat gtg ctc acc aag gct ggc gtg aac 595
Pro Ile Pro Asn Asn Ala Thr Tyr Val Leu Thr Lys Ala Gly Val Asn
150 155 160 165
gcg ttc acc gag gca atg cat tat gag ctg cgc gga act ggt gtg gcg 643
Ala Phe Thr Glu Ala Met His Tyr Glu Leu Arg Gly Thr Gly Val Ala
170 175 180
tgt act ttg ctc gca ccg gga cct gtc cgt gag gcg gag atc cct gag 691
Cys Thr Leu Leu Ala Pro Gly Pro Val Arg Glu Ala Glu Ile Pro Glu
185 190 195
tct gag aag tcg atc gtg gac aag gtt gtc cct gat ttc ttg tgg acc 739
Ser Glu Lys Ser Ile Val Asp Lys Val Val Pro Asp Phe Leu Trp Thr
200 205 210
acc tat gag tcc tgc tcc gca gag acc ttg cgt gcg ctg tct aag aat 787
Thr Tyr Glu Ser Cys Ser Ala Glu Thr Leu Arg Ala Leu Ser Lys Asn
215 220 225
cag cgt cgc gtt gtt cca ggt ccg ctg tcc aag gcc atg aat ttt gtg 835
Gln Arg Arg Val Val Pro Gly Pro Leu Ser Lys Ala Met Asn Phe Val
230 235 240 245
tcc tct gtt gct cca acc gct gtg ctc tcc cct gtt atg ggc tgg gtt 883
Ser Ser Val Ala Pro Thr Ala Val Leu Ser Pro Val Met Gly Trp Val
250 255 260
tat aag aag atg ggt tagtttttaa aagtgtctga atc 921
Tyr Lys Lys Met Gly
265
<210> 174
<211> 266
<212> PRT
<213> Corynebacterium glutamicum
<400> 174
Met Ala Leu Pro Leu Pro Ser Lys Ser Ala Arg Ala Leu Val Thr Gly
1 5 10 15
Ala Ser Gln Gly Ile Gly Leu Ala Ile Ala Lys Asp Leu Ala Arg Tyr
20 25 30
Gly His Asn Leu Ile Leu Val Ala Arg Arg Glu Asp Val Leu Lys Glu
35 40 45
Ile Ala Ala Asp Leu Glu Lys Lys His Gly Val Ile Val Glu Val Arg
50 55 60
Pro Val Asp Leu Ser Asp Glu Pro Ala Arg Lys Val Leu Ile Asp Glu
65 70 75 80
Ile Lys Thr Arg Glu Ile Asn Ile Ile Ile Asn Ser Ala Gly Ile Ala
85 90 95
Ser Phe Gly Pro Phe Lys Asp Gln Asp Trp Ser Tyr Glu Thr Ala Gln
100 105 110
Phe Ser Leu Asn Ala Thr Ala Val Phe Glu Leu Thr His Ala Val Leu
115 120 125
Gly Gly Met Ile Asp Arg Gly Thr Gly Ala Ile Cys Asn Val Gly Ser
130 135 140
Ala Ala Gly Asn Val Pro Ile Pro Asn Asn Ala Thr Tyr Val Leu Thr
145 150 155 160
Lys Ala Gly Val Asn Ala Phe Thr Glu Ala Met His Tyr Glu Leu Arg
165 170 175
Gly Thr Gly Val Ala Cys Thr Leu Leu Ala Pro Gly Pro Val Arg Glu
180 185 190
Ala Glu Ile Pro Glu Ser Glu Lys Ser Ile Val Asp Lys Val Val Pro
195 200 205
Asp Phe Leu Trp Thr Thr Tyr Glu Ser Cys Ser Ala Glu Thr Leu Arg
210 215 220
Ala Leu Ser Lys Asn Gln Arg Arg Val Val Pro Gly Pro Leu Ser Lys
225 230 235 240
Ala Met Asn Phe Val Ser Ser Val Ala Pro Thr Ala Val Leu Ser Pro
245 250 255
Val Met Gly Trp Val Tyr Lys Lys Met Gly
260 265
<210> 175
<211> 1293
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1270)
<223> RXN02062
<400> 175
ttgtctaaac atcgttttgg ggtccgaatg atagcccctt ttaatgcccc catttcggta 60
tcgctgcgca actgttttta gatggctaat ctttgaaatt atg aga gtc gga atg 115
Met Arg Val Gly Met
1 5
atg aca aga gag tat cca cca gag gtt tac ggc ggc gct ggc gtg cac 163
Met Thr Arg Glu Tyr Pro Pro Glu Val Tyr Gly Gly Ala Gly Val His
10 15 20
gtc acc gaa ttg acc cga ttc atg cgt gag atc gct gaa gtt gat gtt 211
Val Thr Glu Leu Thr Arg Phe Met Arg Glu Ile Ala Glu Val Asp Val
25 30 35
cac tgc atg ggt gca cct cgc gat atg gag gga gtt ttc gtc cac ggc 259
His Cys Met Gly Ala Pro Arg Asp Met Glu Gly Val Phe Val His Gly
40 45 50
gtc gat cct gcc ttg gaa agc gcg aac cct gcg att aag aca ctg tcc 307
Val Asp Pro Ala Leu Glu Ser Ala Asn Pro Ala Ile Lys Thr Leu Ser
55 60 65
acc ggt tta cgc atg gca gaa gct gca aac aac gtg gat gtc gtg cac 355
Thr Gly Leu Arg Met Ala Glu Ala Ala Asn Asn Val Asp Val Val His
70 75 80 85
tca cac act tgg tat gca ggt ctt ggc ggc cac ctt gca gct cgt ctc 403
Ser His Thr Trp Tyr Ala Gly Leu Gly Gly His Leu Ala Ala Arg Leu
90 95 100
cac ggc att cct cac gtg gct acc gcg cac tct ttg gag cca gat cgc 451
His Gly Ile Pro His Val Ala Thr Ala His Ser Leu Glu Pro Asp Arg
105 110 115
cca tgg aag cgt gag cag ctt ggc ggt gga tac gac gtg tcc tcc tgg 499
Pro Trp Lys Arg Glu Gln Leu Gly Gly Gly Tyr Asp Val Ser Ser Trp
120 125 130
tct gaa aaa aat gcc atg gaa tac gct gac gcg gtc atc gct gtg tcg 547
Ser Glu Lys Asn Ala Met Glu Tyr Ala Asp Ala Val Ile Ala Val Ser
135 140 145
gct cgc atg aaa gat tcc atc ctc gct gcg tac cct cgc atc gag ccg 595
Ala Arg Met Lys Asp Ser Ile Leu Ala Ala Tyr Pro Arg Ile Glu Pro
150 155 160 165
gac aac gtg cgt gtt gtc ctc aac ggc atc gac act gag ttg tgg cag 643
Asp Asn Val Arg Val Val Leu Asn Gly Ile Asp Thr Glu Leu Trp Gln
170 175 180
cct cgc ccg act ttc gat gac gcg gaa gat tcc gta ctc cgc tcc cta 691
Pro Arg Pro Thr Phe Asp Asp Ala Glu Asp Ser Val Leu Arg Ser Leu
185 190 195
ggc gtt gac cca cag cgg ccc atc gtc gca ttt gtc ggc cgc atc acc 739
Gly Val Asp Pro Gln Arg Pro Ile Val Ala Phe Val Gly Arg Ile Thr
200 205 210
cgc caa aaa ggc gtc gag cac ctc atc aag gca gca gcg ctt ttc gac 787
Arg Gln Lys Gly Val Glu His Leu Ile Lys Ala Ala Ala Leu Phe Asp
215 220 225
gag tcc gtg cag ctt gtg ctc tgt gcc ggc gcg cca gac acc ccc gaa 835
Glu Ser Val Gln Leu Val Leu Cys Ala Gly Ala Pro Asp Thr Pro Glu
230 235 240 245
atc gca gct cgc acc acc gcc ctg gtg gaa gaa ctc cag gca aag cgc 883
Ile Ala Ala Arg Thr Thr Ala Leu Val Glu Glu Leu Gln Ala Lys Arg
250 255 260
gaa ggc att ttc tgg gtt cag gac atg ctg ggc aag gac aaa atc caa 931
Glu Gly Ile Phe Trp Val Gln Asp Met Leu Gly Lys Asp Lys Ile Gln
265 270 275
gag att ctc acc gct gct gac acc ttc gtg tgc cca tcc att tac gag 979
Glu Ile Leu Thr Ala Ala Asp Thr Phe Val Cys Pro Ser Ile Tyr Glu
280 285 290
cca ctg ggc atc gtg aac ttg gaa gca atg gcc tgc aac acc gca gtt 1027
Pro Leu Gly Ile Val Asn Leu Glu Ala Met Ala Cys Asn Thr Ala Val
295 300 305
gtc gca tcc gac gtt gga ggc atc cct gag gtt gtt gtc gac ggc acc 1075
Val Ala Ser Asp Val Gly Gly Ile Pro Glu Val Val Val Asp Gly Thr
310 315 320 325
acc ggc gcc ctc gtt cac tac gac gaa aat gat gtc gaa acc ttc gag 1123
Thr Gly Ala Leu Val His Tyr Asp Glu Asn Asp Val Glu Thr Phe Glu
330 335 340
cgc gat atc gcc gaa gcg gtg aat aaa atg gtc gct gat cga gag acc 1171
Arg Asp Ile Ala Glu Ala Val Asn Lys Met Val Ala Asp Arg Glu Thr
345 350 355
gca gcc aaa ttt ggt ctc gca ggg cgc gaa cgt gct atc aat gat ttc 1219
Ala Ala Lys Phe Gly Leu Ala Gly Arg Glu Arg Ala Ile Asn Asp Phe
360 365 370
tcc tgg gca acg att gct cag cag acc att gat gtg tac aaa tcc ttg 1267
Ser Trp Ala Thr Ile Ala Gln Gln Thr Ile Asp Val Tyr Lys Ser Leu
375 380 385
atg taaaaccgaa agccggggaa cct 1293
Met
390
<210> 176
<211> 390
<212> PRT
<213> Corynebacterium glutamicum
<400> 176
Met Arg Val Gly Met Met Thr Arg Glu Tyr Pro Pro Glu Val Tyr Gly
1 5 10 15
Gly Ala Gly Val His Val Thr Glu Leu Thr Arg Phe Met Arg Glu Ile
20 25 30
Ala Glu Val Asp Val His Cys Met Gly Ala Pro Arg Asp Met Glu Gly
35 40 45
Val Phe Val His Gly Val Asp Pro Ala Leu Glu Ser Ala Asn Pro Ala
50 55 60
Ile Lys Thr Leu Ser Thr Gly Leu Arg Met Ala Glu Ala Ala Asn Asn
65 70 75 80
Val Asp Val Val His Ser His Thr Trp Tyr Ala Gly Leu Gly Gly His
85 90 95
Leu Ala Ala Arg Leu His Gly Ile Pro His Val Ala Thr Ala His Ser
100 105 110
Leu Glu Pro Asp Arg Pro Trp Lys Arg Glu Gln Leu Gly Gly Gly Tyr
115 120 125
Asp Val Ser Ser Trp Ser Glu Lys Asn Ala Met Glu Tyr Ala Asp Ala
130 135 140
Val Ile Ala Val Ser Ala Arg Met Lys Asp Ser Ile Leu Ala Ala Tyr
145 150 155 160
Pro Arg Ile Glu Pro Asp Asn Val Arg Val Val Leu Asn Gly Ile Asp
165 170 175
Thr Glu Leu Trp Gln Pro Arg Pro Thr Phe Asp Asp Ala Glu Asp Ser
180 185 190
Val Leu Arg Ser Leu Gly Val Asp Pro Gln Arg Pro Ile Val Ala Phe
195 200 205
Val Gly Arg Ile Thr Arg Gln Lys Gly Val Glu His Leu Ile Lys Ala
210 215 220
Ala Ala Leu Phe Asp Glu Ser Val Gln Leu Val Leu Cys Ala Gly Ala
225 230 235 240
Pro Asp Thr Pro Glu Ile Ala Ala Arg Thr Thr Ala Leu Val Glu Glu
245 250 255
Leu Gln Ala Lys Arg Glu Gly Ile Phe Trp Val Gln Asp Met Leu Gly
260 265 270
Lys Asp Lys Ile Gln Glu Ile Leu Thr Ala Ala Asp Thr Phe Val Cys
275 280 285
Pro Ser Ile Tyr Glu Pro Leu Gly Ile Val Asn Leu Glu Ala Met Ala
290 295 300
Cys Asn Thr Ala Val Val Ala Ser Asp Val Gly Gly Ile Pro Glu Val
305 310 315 320
Val Val Asp Gly Thr Thr Gly Ala Leu Val His Tyr Asp Glu Asn Asp
325 330 335
Val Glu Thr Phe Glu Arg Asp Ile Ala Glu Ala Val Asn Lys Met Val
340 345 350
Ala Asp Arg Glu Thr Ala Ala Lys Phe Gly Leu Ala Gly Arg Glu Arg
355 360 365
Ala Ile Asn Asp Phe Ser Trp Ala Thr Ile Ala Gln Gln Thr Ile Asp
370 375 380
Val Tyr Lys Ser Leu Met
385 390
<210> 177
<211> 1266
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1243)
<223> RXN02148
<400> 177
gcctcagact acggaatccc tgtgcaggtg gtatctgttg attcagcacc gttttatggt 60
gcgcgtcgct actaagaaat agttcgtcag gagaatcttt gtg tct gca tcc cga 115
Val Ser Ala Ser Arg
1 5
aaa act ctc gtt gtg acc aat gat ttt cct cca cgg atc ggc gga atc 163
Lys Thr Leu Val Val Thr Asn Asp Phe Pro Pro Arg Ile Gly Gly Ile
10 15 20
caa agc tat ttg agg gat ttc atc gct act caa gat cct gag tcg atc 211
Gln Ser Tyr Leu Arg Asp Phe Ile Ala Thr Gln Asp Pro Glu Ser Ile
25 30 35
gtg gtg ttt gcg tcg act caa aac gct gag gaa gcg cat gcc tac gac 259
Val Val Phe Ala Ser Thr Gln Asn Ala Glu Glu Ala His Ala Tyr Asp
40 45 50
aag act ttg gac tat gag gtc att agg tgg cct cgt tcg gtg atg ctg 307
Lys Thr Leu Asp Tyr Glu Val Ile Arg Trp Pro Arg Ser Val Met Leu
55 60 65
ccc acc cca aca acg gca cac gct atg gcg gag atc att cgt gag cga 355
Pro Thr Pro Thr Thr Ala His Ala Met Ala Glu Ile Ile Arg Glu Arg
70 75 80 85
gag atc gat aat gtg tgg ttc ggt gct gcg gct ccg ttg gcg ttg atg 403
Glu Ile Asp Asn Val Trp Phe Gly Ala Ala Ala Pro Leu Ala Leu Met
90 95 100
gca ggc aca gcg aag cag gca ggt gcg agc aag gtt att gcc tcc act 451
Ala Gly Thr Ala Lys Gln Ala Gly Ala Ser Lys Val Ile Ala Ser Thr
105 110 115
cat ggg cat gag gtg ggg tgg tca atg ctt cct gga tcg aga caa tcg 499
His Gly His Glu Val Gly Trp Ser Met Leu Pro Gly Ser Arg Gln Ser
120 125 130
ttg cgc aaa atc ggc act gag gtg gac gtg ctg act tat atc tcg cag 547
Leu Arg Lys Ile Gly Thr Glu Val Asp Val Leu Thr Tyr Ile Ser Gln
135 140 145
tac acg ctg cgc aga ttc aaa agt gct ttt gga tcg cac ccg act ttt 595
Tyr Thr Leu Arg Arg Phe Lys Ser Ala Phe Gly Ser His Pro Thr Phe
150 155 160 165
gaa cat ttg cct tcc ggc gtg gac gtt aag aga ttc act ccg gcc acg 643
Glu His Leu Pro Ser Gly Val Asp Val Lys Arg Phe Thr Pro Ala Thr
170 175 180
cca gag gac aaa agc gca aca agg aaa aag cta gga ttc acg gac acc 691
Pro Glu Asp Lys Ser Ala Thr Arg Lys Lys Leu Gly Phe Thr Asp Thr
185 190 195
acc ccg gtt att gcc tgt aac tcg cgt tta gtg ccg agg aaa ggc cag 739
Thr Pro Val Ile Ala Cys Asn Ser Arg Leu Val Pro Arg Lys Gly Gln
200 205 210
gac tcg ctg atc aag gcg atg cca cag gtg att gcg gcg cgc cca gat 787
Asp Ser Leu Ile Lys Ala Met Pro Gln Val Ile Ala Ala Arg Pro Asp
215 220 225
gcg cag ttg ctc att gtg ggc agt ggg cga tac gag tcg act ttg cgg 835
Ala Gln Leu Leu Ile Val Gly Ser Gly Arg Tyr Glu Ser Thr Leu Arg
230 235 240 245
cgc ctt gcc act gac gtg agc cag aac gtg aaa ttc ctt ggg cgc ctt 883
Arg Leu Ala Thr Asp Val Ser Gln Asn Val Lys Phe Leu Gly Arg Leu
250 255 260
gaa tat caa gat atg atc aac acg ctt gcc gcc gca gat att ttc gcg 931
Glu Tyr Gln Asp Met Ile Asn Thr Leu Ala Ala Ala Asp Ile Phe Ala
265 270 275
atg cca gcg cgc acc cgc ggt ggc gga ctt gat gtt gaa ggc ttg ggc 979
Met Pro Ala Arg Thr Arg Gly Gly Gly Leu Asp Val Glu Gly Leu Gly
280 285 290
att gtc tat ctc gag gca caa gcc tgc gga gtg ccg gtg ata gcc ggc 1027
Ile Val Tyr Leu Glu Ala Gln Ala Cys Gly Val Pro Val Ile Ala Gly
295 300 305
acc tct ggc ggc gcg cca gag acg gtg act ccg gca act ggc ctg gtt 1075
Thr Ser Gly Gly Ala Pro Glu Thr Val Thr Pro Ala Thr Gly Leu Val
310 315 320 325
gtg gag ggg tcg gac gtc gat aag ctg tct gag ctt tta att gag ctt 1123
Val Glu Gly Ser Asp Val Asp Lys Leu Ser Glu Leu Leu Ile Glu Leu
330 335 340
ctc gac gat ccg atc cgc cgc gcc gcg atg ggc gct gca ggt agg gcg 1171
Leu Asp Asp Pro Ile Arg Arg Ala Ala Met Gly Ala Ala Gly Arg Ala
345 350 355
cat gtg gag gcc gaa tgg tcg tgg gaa atc atg ggg gag cgg ttg acc 1219
His Val Glu Ala Glu Trp Ser Trp Glu Ile Met Gly Glu Arg Leu Thr
360 365 370
aat att ttg cag agt gaa cca cga tgatggttgg acagctgttg ata 1266
Asn Ile Leu Gln Ser Glu Pro Arg
375 380
<210> 178
<211> 381
<212> PRT
<213> Corynebacterium glutamicum
<400> 178
Val Ser Ala Ser Arg Lys Thr Leu Val Val Thr Asn Asp Phe Pro Pro
1 5 10 15
Arg Ile Gly Gly Ile Gln Ser Tyr Leu Arg Asp Phe Ile Ala Thr Gln
20 25 30
Asp Pro Glu Ser Ile Val Val Phe Ala Ser Thr Gln Asn Ala Glu Glu
35 40 45
Ala His Ala Tyr Asp Lys Thr Leu Asp Tyr Glu Val Ile Arg Trp Pro
50 55 60
Arg Ser Val Met Leu Pro Thr Pro Thr Thr Ala His Ala Met Ala Glu
65 70 75 80
Ile Ile Arg Glu Arg Glu Ile Asp Asn Val Trp Phe Gly Ala Ala Ala
85 90 95
Pro Leu Ala Leu Met Ala Gly Thr Ala Lys Gln Ala Gly Ala Ser Lys
100 105 110
Val Ile Ala Ser Thr His Gly His Glu Val Gly Trp Ser Met Leu Pro
115 120 125
Gly Ser Arg Gln Ser Leu Arg Lys Ile Gly Thr Glu Val Asp Val Leu
130 135 140
Thr Tyr Ile Ser Gln Tyr Thr Leu Arg Arg Phe Lys Ser Ala Phe Gly
145 150 155 160
Ser His Pro Thr Phe Glu His Leu Pro Ser Gly Val Asp Val Lys Arg
165 170 175
Phe Thr Pro Ala Thr Pro Glu Asp Lys Ser Ala Thr Arg Lys Lys Leu
180 185 190
Gly Phe Thr Asp Thr Thr Pro Val Ile Ala Cys Asn Ser Arg Leu Val
195 200 205
Pro Arg Lys Gly Gln Asp Ser Leu Ile Lys Ala Met Pro Gln Val Ile
210 215 220
Ala Ala Arg Pro Asp Ala Gln Leu Leu Ile Val Gly Ser Gly Arg Tyr
225 230 235 240
Glu Ser Thr Leu Arg Arg Leu Ala Thr Asp Val Ser Gln Asn Val Lys
245 250 255
Phe Leu Gly Arg Leu Glu Tyr Gln Asp Met Ile Asn Thr Leu Ala Ala
260 265 270
Ala Asp Ile Phe Ala Met Pro Ala Arg Thr Arg Gly Gly Gly Leu Asp
275 280 285
Val Glu Gly Leu Gly Ile Val Tyr Leu Glu Ala Gln Ala Cys Gly Val
290 295 300
Pro Val Ile Ala Gly Thr Ser Gly Gly Ala Pro Glu Thr Val Thr Pro
305 310 315 320
Ala Thr Gly Leu Val Val Glu Gly Ser Asp Val Asp Lys Leu Ser Glu
325 330 335
Leu Leu Ile Glu Leu Leu Asp Asp Pro Ile Arg Arg Ala Ala Met Gly
340 345 350
Ala Ala Gly Arg Ala His Val Glu Ala Glu Trp Ser Trp Glu Ile Met
355 360 365
Gly Glu Arg Leu Thr Asn Ile Leu Gln Ser Glu Pro Arg
370 375 380
<210> 179
<211> 1287
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1264)
<223> RXN02595
<400> 179
gtgggtaaag gggactccga ggaagtccac gtcgtcttct ttcgcggcgc tgaggatggt 60
ttcgcggatt tgtgcggggg agtgggtggg agagaaaacg gtg atc gtt gtg gcc 115
Val Ile Val Val Ala
1 5
atg gct tcc att atg gct tgt tta aaa gca gct aga ctg aat aac cct 163
Met Ala Ser Ile Met Ala Cys Leu Lys Ala Ala Arg Leu Asn Asn Pro
10 15 20
atg aag atc ctt ttg ttg tgc tgg cgt gat acc act cat cct caa ggt 211
Met Lys Ile Leu Leu Leu Cys Trp Arg Asp Thr Thr His Pro Gln Gly
25 30 35
ggc gga agt gaa cgc tat ctg gag cgg gtg ggt gag ttt ttg gcg gat 259
Gly Gly Ser Glu Arg Tyr Leu Glu Arg Val Gly Glu Phe Leu Ala Asp
40 45 50
cag ggc cat gag gtg gtg ttt cgt act gct ggg cac acg gat gcg cca 307
Gln Gly His Glu Val Val Phe Arg Thr Ala Gly His Thr Asp Ala Pro
55 60 65
cgg cgt tct ttc cgc gat ggt gtg agg tat tcc agg agc ggt ggg aag 355
Arg Arg Ser Phe Arg Asp Gly Val Arg Tyr Ser Arg Ser Gly Gly Lys
70 75 80 85
ttt agt gtg tat ccc aag gcg tgg gtg gcc atg atg ttg ggt cgt gtg 403
Phe Ser Val Tyr Pro Lys Ala Trp Val Ala Met Met Leu Gly Arg Val
90 95 100
ggg att ggc acg ttt tcc aag gtt gat gtg gtg gtg gat acg cag aat 451
Gly Ile Gly Thr Phe Ser Lys Val Asp Val Val Val Asp Thr Gln Asn
105 110 115
ggc att ccg ttt ttt gga aag ttt ttc tcc ggt aag ccg act gtg ttg 499
Gly Ile Pro Phe Phe Gly Lys Phe Phe Ser Gly Lys Pro Thr Val Leu
120 125 130
ctc acg cat cat tgc cat aag gag cag tgg ccg gtg gtg ggt cgg gtg 547
Leu Thr His His Cys His Lys Glu Gln Trp Pro Val Val Gly Arg Val
135 140 145
ctg gcg aag gtt ggt tgg ctg att gag agc cag atc gcg ccg cgc gct 595
Leu Ala Lys Val Gly Trp Leu Ile Glu Ser Gln Ile Ala Pro Arg Ala
150 155 160 165
tac aaa act gcg ccg tat gtg act gtt tca gag ccg agc gct gag gag 643
Tyr Lys Thr Ala Pro Tyr Val Thr Val Ser Glu Pro Ser Ala Glu Glu
170 175 180
ctc att gcg ttg ggt gtg gat cag cag cgg att cat atc gtg cgc aat 691
Leu Ile Ala Leu Gly Val Asp Gln Gln Arg Ile His Ile Val Arg Asn
185 190 195
ggc gtg gat ccc gtg ccg ctg cac acg ccg aag ctg gat cgc gat ggc 739
Gly Val Asp Pro Val Pro Leu His Thr Pro Lys Leu Asp Arg Asp Gly
200 205 210
cag cat gcg gtg acg ttg tcg cgc ctg gtt ccg cac aag cag att gag 787
Gln His Ala Val Thr Leu Ser Arg Leu Val Pro His Lys Gln Ile Glu
215 220 225
cat gcg atg gat gtc gtc gcg gcg ctc gac ggc gtg gtg ctg gat gta 835
His Ala Met Asp Val Val Ala Ala Leu Asp Gly Val Val Leu Asp Val
230 235 240 245
gtc gaa agc ggt tgg tgg cag aag gaa ctg gtc gat tat gcc cgc acg 883
Val Glu Ser Gly Trp Trp Gln Lys Glu Leu Val Asp Tyr Ala Arg Thr
250 255 260
ctg ggt gtg agc gat cgc gtg gtt ttc cac ggc cag gtc gcc gag gat 931
Leu Gly Val Ser Asp Arg Val Val Phe His Gly Gln Val Ala Glu Asp
265 270 275
cac aag cac gcc ctg ttg gag cgc gcc acg att cat ctc atg cct tcg 979
His Lys His Ala Leu Leu Glu Arg Ala Thr Ile His Leu Met Pro Ser
280 285 290
cgc aag gaa ggc tgg ggc ctg gcg gtc acg gag gcg gcg cag cac ggc 1027
Arg Lys Glu Gly Trp Gly Leu Ala Val Thr Glu Ala Ala Gln His Gly
295 300 305
gtt ccg acg atc ggt tac cga agc tca ggc ggc ctg cgc gat tcc gtc 1075
Val Pro Thr Ile Gly Tyr Arg Ser Ser Gly Gly Leu Arg Asp Ser Val
310 315 320 325
gtc gac ggc gaa acc ggc ctg ctt gtc gac tcc aag gcc gag ctt att 1123
Val Asp Gly Glu Thr Gly Leu Leu Val Asp Ser Lys Ala Glu Leu Ile
330 335 340
tca gcc acc aaa acc ctg ctt atc gac gcc tcc ctc cgc tcc aag ctc 1171
Ser Ala Thr Lys Thr Leu Leu Ile Asp Ala Ser Leu Arg Ser Lys Leu
345 350 355
ggc gcc agc gcg aag cag cgc gcc gaa aac tac aag tgg gac acc gcg 1219
Gly Ala Ser Ala Lys Gln Arg Ala Glu Asn Tyr Lys Trp Asp Thr Ala
360 365 370
gga gcg cag ttc gag gaa cta ctt ctt ggt ctt gcg tcg aaa aag 1264
Gly Ala Gln Phe Glu Glu Leu Leu Leu Gly Leu Ala Ser Lys Lys
375 380 385
tagtcccagc ggcaacgcca tcc 1287
<210> 180
<211> 388
<212> PRT
<213> Corynebacterium glutamicum
<400> 180
Val Ile Val Val Ala Met Ala Ser Ile Met Ala Cys Leu Lys Ala Ala
1 5 10 15
Arg Leu Asn Asn Pro Met Lys Ile Leu Leu Leu Cys Trp Arg Asp Thr
20 25 30
Thr His Pro Gln Gly Gly Gly Ser Glu Arg Tyr Leu Glu Arg Val Gly
35 40 45
Glu Phe Leu Ala Asp Gln Gly His Glu Val Val Phe Arg Thr Ala Gly
50 55 60
His Thr Asp Ala Pro Arg Arg Ser Phe Arg Asp Gly Val Arg Tyr Ser
65 70 75 80
Arg Ser Gly Gly Lys Phe Ser Val Tyr Pro Lys Ala Trp Val Ala Met
85 90 95
Met Leu Gly Arg Val Gly Ile Gly Thr Phe Ser Lys Val Asp Val Val
100 105 110
Val Asp Thr Gln Asn Gly Ile Pro Phe Phe Gly Lys Phe Phe Ser Gly
115 120 125
Lys Pro Thr Val Leu Leu Thr His His Cys His Lys Glu Gln Trp Pro
130 135 140
Val Val Gly Arg Val Leu Ala Lys Val Gly Trp Leu Ile Glu Ser Gln
145 150 155 160
Ile Ala Pro Arg Ala Tyr Lys Thr Ala Pro Tyr Val Thr Val Ser Glu
165 170 175
Pro Ser Ala Glu Glu Leu Ile Ala Leu Gly Val Asp Gln Gln Arg Ile
180 185 190
His Ile Val Arg Asn Gly Val Asp Pro Val Pro Leu His Thr Pro Lys
195 200 205
Leu Asp Arg Asp Gly Gln His Ala Val Thr Leu Ser Arg Leu Val Pro
210 215 220
His Lys Gln Ile Glu His Ala Met Asp Val Val Ala Ala Leu Asp Gly
225 230 235 240
Val Val Leu Asp Val Val Glu Ser Gly Trp Trp Gln Lys Glu Leu Val
245 250 255
Asp Tyr Ala Arg Thr Leu Gly Val Ser Asp Arg Val Val Phe His Gly
260 265 270
Gln Val Ala Glu Asp His Lys His Ala Leu Leu Glu Arg Ala Thr Ile
275 280 285
His Leu Met Pro Ser Arg Lys Glu Gly Trp Gly Leu Ala Val Thr Glu
290 295 300
Ala Ala Gln His Gly Val Pro Thr Ile Gly Tyr Arg Ser Ser Gly Gly
305 310 315 320
Leu Arg Asp Ser Val Val Asp Gly Glu Thr Gly Leu Leu Val Asp Ser
325 330 335
Lys Ala Glu Leu Ile Ser Ala Thr Lys Thr Leu Leu Ile Asp Ala Ser
340 345 350
Leu Arg Ser Lys Leu Gly Ala Ser Ala Lys Gln Arg Ala Glu Asn Tyr
355 360 365
Lys Trp Asp Thr Ala Gly Ala Gln Phe Glu Glu Leu Leu Leu Gly Leu
370 375 380
Ala Ser Lys Lys
385
<210> 181
<211> 2334
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(2311)
<223> RXS00148
<400> 181
ctttgagggc agcgcgcatg cgcccgatgg ttatttgaac atgacaattg atgccgcggc 60
gacgctggct gacctgctag atgctttggg agcttaaatc atg acg tcg atc cct 115
Met Thr Ser Ile Pro
1 5
aat ttt tca gac atc cca ttg act gct gag aca cgt gca tcg gag tca 163
Asn Phe Ser Asp Ile Pro Leu Thr Ala Glu Thr Arg Ala Ser Glu Ser
10 15 20
cac aac gtt gac gcc ggc aag gtg tgg aac act ccc gaa ggc att gat 211
His Asn Val Asp Ala Gly Lys Val Trp Asn Thr Pro Glu Gly Ile Asp
25 30 35
gtc aag cgc gta ttc acg cag gct gac cgc gac gag gcg caa gcg gcg 259
Val Lys Arg Val Phe Thr Gln Ala Asp Arg Asp Glu Ala Gln Ala Ala
40 45 50
gga cat ccg gtg gat tct ttg cca ggt caa aag cca ttt atg cgc ggg 307
Gly His Pro Val Asp Ser Leu Pro Gly Gln Lys Pro Phe Met Arg Gly
55 60 65
ccg tac cca act atg tac acc aat cag ccg tgg acg att cgc cag tac 355
Pro Tyr Pro Thr Met Tyr Thr Asn Gln Pro Trp Thr Ile Arg Gln Tyr
70 75 80 85
gca ggc ttt tca acc gcc gcg gaa tcc aat gcg ttt tat cgg agg aac 403
Ala Gly Phe Ser Thr Ala Ala Glu Ser Asn Ala Phe Tyr Arg Arg Asn
90 95 100
ctt gct gcg ggt caa aaa ggt ttg tcg gtt gcg ttc gat cta gcg acc 451
Leu Ala Ala Gly Gln Lys Gly Leu Ser Val Ala Phe Asp Leu Ala Thr
105 110 115
cac cgc ggt tat gac tcg gat aat gag cgc gtg gtc ggc gat gtg ggt 499
His Arg Gly Tyr Asp Ser Asp Asn Glu Arg Val Val Gly Asp Val Gly
120 125 130
atg gcc ggc gtg gcg att gat tcg att ttg gat atg cgt cag ctg ttt 547
Met Ala Gly Val Ala Ile Asp Ser Ile Leu Asp Met Arg Gln Leu Phe
135 140 145
gat ggc att gat ttg tcc agc gtg tcg gtg tcg atg acc atg aat ggc 595
Asp Gly Ile Asp Leu Ser Ser Val Ser Val Ser Met Thr Met Asn Gly
150 155 160 165
gct gtg ctg ccg att ctt gcg ttc tat atc gtg gcg gct gag gaa caa 643
Ala Val Leu Pro Ile Leu Ala Phe Tyr Ile Val Ala Ala Glu Glu Gln
170 175 180
ggt gtg ggt ccg gag cag ctt gcg ggc acg atc cag aat gac atc ttg 691
Gly Val Gly Pro Glu Gln Leu Ala Gly Thr Ile Gln Asn Asp Ile Leu
185 190 195
aaa gaa ttt atg gtg cgc aac acc tat att tat ccg ccg aag ccg tcg 739
Lys Glu Phe Met Val Arg Asn Thr Tyr Ile Tyr Pro Pro Lys Pro Ser
200 205 210
atg cgc atc att tcc aac atc ttt gag tac acc tcc ttg aag atg cca 787
Met Arg Ile Ile Ser Asn Ile Phe Glu Tyr Thr Ser Leu Lys Met Pro
215 220 225
cgt ttt aac tcc att tcg att tct ggc tat cac atc cag gaa gcg gga 835
Arg Phe Asn Ser Ile Ser Ile Ser Gly Tyr His Ile Gln Glu Ala Gly
230 235 240 245
gcg act gcc gat ttg gag ctg gcc tac act ctg gcg gat ggt att gaa 883
Ala Thr Ala Asp Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Ile Glu
250 255 260
tac atc cgt gca ggt aaa gag gta ggc ctt gac gtg gat aag ttc gcg 931
Tyr Ile Arg Ala Gly Lys Glu Val Gly Leu Asp Val Asp Lys Phe Ala
265 270 275
cct cgt ctg tcc ttc ttc tgg ggt att tct atg tac acc ttc atg gag 979
Pro Arg Leu Ser Phe Phe Trp Gly Ile Ser Met Tyr Thr Phe Met Glu
280 285 290
atc gca aag ctg cgt gcg gga cga ctg ctg tgg agc gag ttg gtg gca 1027
Ile Ala Lys Leu Arg Ala Gly Arg Leu Leu Trp Ser Glu Leu Val Ala
295 300 305
aaa ttc gat ccg aaa aac gcc aag tcc cag tcg ctg cgc acg cac tcg 1075
Lys Phe Asp Pro Lys Asn Ala Lys Ser Gln Ser Leu Arg Thr His Ser
310 315 320 325
cag acc tct ggt tgg tcg ttg acc gcg cag gat gtg tac aac aac gtc 1123
Gln Thr Ser Gly Trp Ser Leu Thr Ala Gln Asp Val Tyr Asn Asn Val
330 335 340
gcc cgc acc gcg att gag gcg atg gct gca acc cag ggc cac acc cag 1171
Ala Arg Thr Ala Ile Glu Ala Met Ala Ala Thr Gln Gly His Thr Gln
345 350 355
tcg ctg cac acc aat gca ctt gat gag gcg ttg gcg ctg ccc acc gat 1219
Ser Leu His Thr Asn Ala Leu Asp Glu Ala Leu Ala Leu Pro Thr Asp
360 365 370
ttc tct gct cgt atc gcc cga aac acc cag ctg ttg ctg cag cag gaa 1267
Phe Ser Ala Arg Ile Ala Arg Asn Thr Gln Leu Leu Leu Gln Gln Glu
375 380 385
tct ggc acg gtg cgt cca gtt gat cca tgg gcg ggc tcc tat tac gtg 1315
Ser Gly Thr Val Arg Pro Val Asp Pro Trp Ala Gly Ser Tyr Tyr Val
390 395 400 405
gag tgg ttg acc aat gag ctg gct aac cgc gcg cgc aag cac atc gat 1363
Glu Trp Leu Thr Asn Glu Leu Ala Asn Arg Ala Arg Lys His Ile Asp
410 415 420
gag gtg gag gaa gcc ggc gga atg gcg cag gcc acc gcg cag gga att 1411
Glu Val Glu Glu Ala Gly Gly Met Ala Gln Ala Thr Ala Gln Gly Ile
425 430 435
cct aag ctg cgc att gag gaa tca gcg gca cgc acc cag gct cgc att 1459
Pro Lys Leu Arg Ile Glu Glu Ser Ala Ala Arg Thr Gln Ala Arg Ile
440 445 450
gat tcc ggc cgc cag gcg ctg atc ggc gtg aat cgc tac gtg gcg gaa 1507
Asp Ser Gly Arg Gln Ala Leu Ile Gly Val Asn Arg Tyr Val Ala Glu
455 460 465
gaa gat gag gaa att gaa gtc ctc aag gtt gac aac acc aag gtt cgc 1555
Glu Asp Glu Glu Ile Glu Val Leu Lys Val Asp Asn Thr Lys Val Arg
470 475 480 485
gca gaa cag ttg gct aaa ctc gcg caa ctg aaa gca gag cgc aac gat 1603
Ala Glu Gln Leu Ala Lys Leu Ala Gln Leu Lys Ala Glu Arg Asn Asp
490 495 500
gcg gaa gtc aag gct gcg ctg gat gcg ttg aca gct gct gcc cgc aac 1651
Ala Glu Val Lys Ala Ala Leu Asp Ala Leu Thr Ala Ala Ala Arg Asn
505 510 515
gag cat aaa gag cca ggg gat ttg gat cag aac ctg ctc aaa ctt gcc 1699
Glu His Lys Glu Pro Gly Asp Leu Asp Gln Asn Leu Leu Lys Leu Ala
520 525 530
gtc gat gct gcg cgc gca aaa gct acc att gga gag atc tcc gat gct 1747
Val Asp Ala Ala Arg Ala Lys Ala Thr Ile Gly Glu Ile Ser Asp Ala
535 540 545
ttg gaa gtt gtc ttt ggc cgc cac gaa gca gaa atc agg acg ctg tct 1795
Leu Glu Val Val Phe Gly Arg His Glu Ala Glu Ile Arg Thr Leu Ser
550 555 560 565
ggc gtg tac aag gat gag gtt gga aag gaa ggc aca gtg agc aac gtc 1843
Gly Val Tyr Lys Asp Glu Val Gly Lys Glu Gly Thr Val Ser Asn Val
570 575 580
gaa cgc gcg atc gcc ctg gct gac gcc ttt gag gct gag gaa ggc cgc 1891
Glu Arg Ala Ile Ala Leu Ala Asp Ala Phe Glu Ala Glu Glu Gly Arg
585 590 595
cgc cca cgt atc ttt att gcc aag atg ggc cag gat gga cat gac cgt 1939
Arg Pro Arg Ile Phe Ile Ala Lys Met Gly Gln Asp Gly His Asp Arg
600 605 610
gga cag aag gtt gtc gcg tct gcc tat gct gac ctg ggc atg gac gtg 1987
Gly Gln Lys Val Val Ala Ser Ala Tyr Ala Asp Leu Gly Met Asp Val
615 620 625
gat gtt gga ccg ctg ttt caa act cca gcc gaa gct gcc cgc gcc gcc 2035
Asp Val Gly Pro Leu Phe Gln Thr Pro Ala Glu Ala Ala Arg Ala Ala
630 635 640 645
gtg gac gcc gat gtt cac gtg gtg ggt atg tct tcg ctg gca gca ggc 2083
Val Asp Ala Asp Val His Val Val Gly Met Ser Ser Leu Ala Ala Gly
650 655 660
cac ctc acc ttg ctg ccc gag ctg aag aaa gaa ctt gca gct ctt ggc 2131
His Leu Thr Leu Leu Pro Glu Leu Lys Lys Glu Leu Ala Ala Leu Gly
665 670 675
cgc gat gac att ctg gtc acc gtg ggc ggc gtc att ccg ccg ggc gat 2179
Arg Asp Asp Ile Leu Val Thr Val Gly Gly Val Ile Pro Pro Gly Asp
680 685 690
ttc cag gat ctc tac gat atg ggt gcc gcc gcg att tac cct tca gga 2227
Phe Gln Asp Leu Tyr Asp Met Gly Ala Ala Ala Ile Tyr Pro Ser Gly
695 700 705
acc gtc atc gcg gag tcg gcg atc gat ctg atc acc cga ctc gcc gca 2275
Thr Val Ile Ala Glu Ser Ala Ile Asp Leu Ile Thr Arg Leu Ala Ala
710 715 720 725
cac ctg ggc ttt gac ctg gat gtg gat gtg aat gaa tgatcacggt 2321
His Leu Gly Phe Asp Leu Asp Val Asp Val Asn Glu
730 735
ttcctagaag aca 2334
<210> 182
<211> 737
<212> PRT
<213> Corynebacterium glutamicum
<400> 182
Met Thr Ser Ile Pro Asn Phe Ser Asp Ile Pro Leu Thr Ala Glu Thr
1 5 10 15
Arg Ala Ser Glu Ser His Asn Val Asp Ala Gly Lys Val Trp Asn Thr
20 25 30
Pro Glu Gly Ile Asp Val Lys Arg Val Phe Thr Gln Ala Asp Arg Asp
35 40 45
Glu Ala Gln Ala Ala Gly His Pro Val Asp Ser Leu Pro Gly Gln Lys
50 55 60
Pro Phe Met Arg Gly Pro Tyr Pro Thr Met Tyr Thr Asn Gln Pro Trp
65 70 75 80
Thr Ile Arg Gln Tyr Ala Gly Phe Ser Thr Ala Ala Glu Ser Asn Ala
85 90 95
Phe Tyr Arg Arg Asn Leu Ala Ala Gly Gln Lys Gly Leu Ser Val Ala
100 105 110
Phe Asp Leu Ala Thr His Arg Gly Tyr Asp Ser Asp Asn Glu Arg Val
115 120 125
Val Gly Asp Val Gly Met Ala Gly Val Ala Ile Asp Ser Ile Leu Asp
130 135 140
Met Arg Gln Leu Phe Asp Gly Ile Asp Leu Ser Ser Val Ser Val Ser
145 150 155 160
Met Thr Met Asn Gly Ala Val Leu Pro Ile Leu Ala Phe Tyr Ile Val
165 170 175
Ala Ala Glu Glu Gln Gly Val Gly Pro Glu Gln Leu Ala Gly Thr Ile
180 185 190
Gln Asn Asp Ile Leu Lys Glu Phe Met Val Arg Asn Thr Tyr Ile Tyr
195 200 205
Pro Pro Lys Pro Ser Met Arg Ile Ile Ser Asn Ile Phe Glu Tyr Thr
210 215 220
Ser Leu Lys Met Pro Arg Phe Asn Ser Ile Ser Ile Ser Gly Tyr His
225 230 235 240
Ile Gln Glu Ala Gly Ala Thr Ala Asp Leu Glu Leu Ala Tyr Thr Leu
245 250 255
Ala Asp Gly Ile Glu Tyr Ile Arg Ala Gly Lys Glu Val Gly Leu Asp
260 265 270
Val Asp Lys Phe Ala Pro Arg Leu Ser Phe Phe Trp Gly Ile Ser Met
275 280 285
Tyr Thr Phe Met Glu Ile Ala Lys Leu Arg Ala Gly Arg Leu Leu Trp
290 295 300
Ser Glu Leu Val Ala Lys Phe Asp Pro Lys Asn Ala Lys Ser Gln Ser
305 310 315 320
Leu Arg Thr His Ser Gln Thr Ser Gly Trp Ser Leu Thr Ala Gln Asp
325 330 335
Val Tyr Asn Asn Val Ala Arg Thr Ala Ile Glu Ala Met Ala Ala Thr
340 345 350
Gln Gly His Thr Gln Ser Leu His Thr Asn Ala Leu Asp Glu Ala Leu
355 360 365
Ala Leu Pro Thr Asp Phe Ser Ala Arg Ile Ala Arg Asn Thr Gln Leu
370 375 380
Leu Leu Gln Gln Glu Ser Gly Thr Val Arg Pro Val Asp Pro Trp Ala
385 390 395 400
Gly Ser Tyr Tyr Val Glu Trp Leu Thr Asn Glu Leu Ala Asn Arg Ala
405 410 415
Arg Lys His Ile Asp Glu Val Glu Glu Ala Gly Gly Met Ala Gln Ala
420 425 430
Thr Ala Gln Gly Ile Pro Lys Leu Arg Ile Glu Glu Ser Ala Ala Arg
435 440 445
Thr Gln Ala Arg Ile Asp Ser Gly Arg Gln Ala Leu Ile Gly Val Asn
450 455 460
Arg Tyr Val Ala Glu Glu Asp Glu Glu Ile Glu Val Leu Lys Val Asp
465 470 475 480
Asn Thr Lys Val Arg Ala Glu Gln Leu Ala Lys Leu Ala Gln Leu Lys
485 490 495
Ala Glu Arg Asn Asp Ala Glu Val Lys Ala Ala Leu Asp Ala Leu Thr
500 505 510
Ala Ala Ala Arg Asn Glu His Lys Glu Pro Gly Asp Leu Asp Gln Asn
515 520 525
Leu Leu Lys Leu Ala Val Asp Ala Ala Arg Ala Lys Ala Thr Ile Gly
530 535 540
Glu Ile Ser Asp Ala Leu Glu Val Val Phe Gly Arg His Glu Ala Glu
545 550 555 560
Ile Arg Thr Leu Ser Gly Val Tyr Lys Asp Glu Val Gly Lys Glu Gly
565 570 575
Thr Val Ser Asn Val Glu Arg Ala Ile Ala Leu Ala Asp Ala Phe Glu
580 585 590
Ala Glu Glu Gly Arg Arg Pro Arg Ile Phe Ile Ala Lys Met Gly Gln
595 600 605
Asp Gly His Asp Arg Gly Gln Lys Val Val Ala Ser Ala Tyr Ala Asp
610 615 620
Leu Gly Met Asp Val Asp Val Gly Pro Leu Phe Gln Thr Pro Ala Glu
625 630 635 640
Ala Ala Arg Ala Ala Val Asp Ala Asp Val His Val Val Gly Met Ser
645 650 655
Ser Leu Ala Ala Gly His Leu Thr Leu Leu Pro Glu Leu Lys Lys Glu
660 665 670
Leu Ala Ala Leu Gly Arg Asp Asp Ile Leu Val Thr Val Gly Gly Val
675 680 685
Ile Pro Pro Gly Asp Phe Gln Asp Leu Tyr Asp Met Gly Ala Ala Ala
690 695 700
Ile Tyr Pro Ser Gly Thr Val Ile Ala Glu Ser Ala Ile Asp Leu Ile
705 710 715 720
Thr Arg Leu Ala Ala His Leu Gly Phe Asp Leu Asp Val Asp Val Asn
725 730 735
Glu
<210> 183
<211> 1971
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1948)
<223> RXS00149
<400> 183
ttttcgtagg taaacacagg tgaaggcttt acaagcttgt gaactcccta cacaaaagca 60
atccaatagc tatccataag caagagaaag taagtctacg ttg act gat ctc aca 115
Leu Thr Asp Leu Thr
1 5
aag act gcg gtg ccc gag gaa ctt tca gag aac ctc gaa act tgg tac 163
Lys Thr Ala Val Pro Glu Glu Leu Ser Glu Asn Leu Glu Thr Trp Tyr
10 15 20
aag gct gtg gcc ggt gtt ttc gcg cgc aca cag aaa aaa gac atc ggc 211
Lys Ala Val Ala Gly Val Phe Ala Arg Thr Gln Lys Lys Asp Ile Gly
25 30 35
gac att gcc gta gat gtg tgg aag aaa ctc atc gtc act aca ccg gat 259
Asp Ile Ala Val Asp Val Trp Lys Lys Leu Ile Val Thr Thr Pro Asp
40 45 50
ggt gtt gat atc aat ccg ctg tac acc aga gca gat gag tcc cag agg 307
Gly Val Asp Ile Asn Pro Leu Tyr Thr Arg Ala Asp Glu Ser Gln Arg
55 60 65
aaa ttc act gag gtt cct ggt gag ttt ccc ttc act agg gga acc act 355
Lys Phe Thr Glu Val Pro Gly Glu Phe Pro Phe Thr Arg Gly Thr Thr
70 75 80 85
gtt gat ggt gaa cgc gtt ggt tgg ggt gtt act gag act ttc gga cat 403
Val Asp Gly Glu Arg Val Gly Trp Gly Val Thr Glu Thr Phe Gly His
90 95 100
gac agc ccg aag aat atc aac gct gcg gtg ctg aat gct ctg aat tct 451
Asp Ser Pro Lys Asn Ile Asn Ala Ala Val Leu Asn Ala Leu Asn Ser
105 110 115
ggc acc acc aca ttg ggt ttt gag ttc tct gag gaa ttc acg gca gct 499
Gly Thr Thr Thr Leu Gly Phe Glu Phe Ser Glu Glu Phe Thr Ala Ala
120 125 130
gat ctt aaa gtt gct ctc gaa ggc gtg tat ctc aac atg gct ccg ttg 547
Asp Leu Lys Val Ala Leu Glu Gly Val Tyr Leu Asn Met Ala Pro Leu
135 140 145
ctg att cat gcg ggt gga tcc acg tca gag gtt gca gcg gcg ttg tat 595
Leu Ile His Ala Gly Gly Ser Thr Ser Glu Val Ala Ala Ala Leu Tyr
150 155 160 165
acg ttg gcg gag gaa gcc gga acg ttt ttt gct gcg ttg acc ttg ggt 643
Thr Leu Ala Glu Glu Ala Gly Thr Phe Phe Ala Ala Leu Thr Leu Gly
170 175 180
tct cgt cct ttg acg gcg cag gtt gat ggt tcg cac agt gac acc att 691
Ser Arg Pro Leu Thr Ala Gln Val Asp Gly Ser His Ser Asp Thr Ile
185 190 195
gaa gaa gca gtt cag ttg gca gtg aat gct tcc aag cgt gcg aat gtg 739
Glu Glu Ala Val Gln Leu Ala Val Asn Ala Ser Lys Arg Ala Asn Val
200 205 210
cgc gct atc ttg gtg gat ggt tcc agt ttt tcc aac cag ggc gcg tcg 787
Arg Ala Ile Leu Val Asp Gly Ser Ser Phe Ser Asn Gln Gly Ala Ser
215 220 225
gat gct caa gaa att ggt cta agt atc gcc gcc ggt gtg gat tat gtc 835
Asp Ala Gln Glu Ile Gly Leu Ser Ile Ala Ala Gly Val Asp Tyr Val
230 235 240 245
cgt cgc ttg gtc gat gca ggc ctt tcc acg gaa gct gca ctt aag cag 883
Arg Arg Leu Val Asp Ala Gly Leu Ser Thr Glu Ala Ala Leu Lys Gln
250 255 260
gtg gcg ttc cgt ttt gcg gtc acc gat gag cag ttc gcg cag att tct 931
Val Ala Phe Arg Phe Ala Val Thr Asp Glu Gln Phe Ala Gln Ile Ser
265 270 275
aag ctg cgt gtg gct cga cgt ctg tgg gcc agg gtg tgt gag gtg ctt 979
Lys Leu Arg Val Ala Arg Arg Leu Trp Ala Arg Val Cys Glu Val Leu
280 285 290
ggt ttt cca gag ctg gcc gta gca cca cag cat gcg gtg act gca cga 1027
Gly Phe Pro Glu Leu Ala Val Ala Pro Gln His Ala Val Thr Ala Arg
295 300 305
gcg atg ttt agc cag cgt gat ccg tgg gtg aat atg ctg cgc agt act 1075
Ala Met Phe Ser Gln Arg Asp Pro Trp Val Asn Met Leu Arg Ser Thr
310 315 320 325
gtt gca gct ttc gct gca ggc gtc ggt gga gca acc gat gtg gag gtt 1123
Val Ala Ala Phe Ala Ala Gly Val Gly Gly Ala Thr Asp Val Glu Val
330 335 340
cgt act ttt gat gat gcg atc cca gat gga gtt cct gga gtg tcg agg 1171
Arg Thr Phe Asp Asp Ala Ile Pro Asp Gly Val Pro Gly Val Ser Arg
345 350 355
aat ttc gct cac cgc atc gcg cgc aat act aat ttg ttg ttg cta gaa 1219
Asn Phe Ala His Arg Ile Ala Arg Asn Thr Asn Leu Leu Leu Leu Glu
360 365 370
gag tca cat ctt ggt cac gtg gtt gat cct gct ggt gga tca tat ttc 1267
Glu Ser His Leu Gly His Val Val Asp Pro Ala Gly Gly Ser Tyr Phe
375 380 385
gtg gag agc ttc acc gat gat cta gcg gag aag gcg tgg gct gtg ttc 1315
Val Glu Ser Phe Thr Asp Asp Leu Ala Glu Lys Ala Trp Ala Val Phe
390 395 400 405
agt ggc atc gaa gct gag ggc gga tac agt gca gct tgt gca tcc ggc 1363
Ser Gly Ile Glu Ala Glu Gly Gly Tyr Ser Ala Ala Cys Ala Ser Gly
410 415 420
acg gtg act gcc atg ctt gat cag acg tgg gag cag act cgc gct gat 1411
Thr Val Thr Ala Met Leu Asp Gln Thr Trp Glu Gln Thr Arg Ala Asp
425 430 435
gtg gcg tcg aga aag aag aag ctc act gga att aat gag ttc ccg aac 1459
Val Ala Ser Arg Lys Lys Lys Leu Thr Gly Ile Asn Glu Phe Pro Asn
440 445 450
ttg gcg gag tct ccg ctg cca gct gat cgt cgg gta gaa cct gca ggt 1507
Leu Ala Glu Ser Pro Leu Pro Ala Asp Arg Arg Val Glu Pro Ala Gly
455 460 465
gtg cgt cga tgg gca gcg gat ttt gaa gcg ctg cgc aat cgt tcg gat 1555
Val Arg Arg Trp Ala Ala Asp Phe Glu Ala Leu Arg Asn Arg Ser Asp
470 475 480 485
gct ttc ttg gaa aag aac ggc gcg agg cca cag atc acg atg att cct 1603
Ala Phe Leu Glu Lys Asn Gly Ala Arg Pro Gln Ile Thr Met Ile Pro
490 495 500
ctg gga ccg ttg tcc aag cac aat att cgc act ggt ttt act tcc aac 1651
Leu Gly Pro Leu Ser Lys His Asn Ile Arg Thr Gly Phe Thr Ser Asn
505 510 515
ctg ttg gct tcc ggt ggc att gaa gca atc aac ccg ggt caa ctt gtt 1699
Leu Leu Ala Ser Gly Gly Ile Glu Ala Ile Asn Pro Gly Gln Leu Val
520 525 530
ccc ggc act gac gct ttt gca gaa gct gca cag gcc gca ggc att gta 1747
Pro Gly Thr Asp Ala Phe Ala Glu Ala Ala Gln Ala Ala Gly Ile Val
535 540 545
gtg gtg tgt gga acg gac caa gag tat gcc gaa acg ggg gag gga gcc 1795
Val Val Cys Gly Thr Asp Gln Glu Tyr Ala Glu Thr Gly Glu Gly Ala
550 555 560 565
gtc gaa aag ctc cgc gaa gcg ggc gtt gag cgc atc ctg ctt gct ggc 1843
Val Glu Lys Leu Arg Glu Ala Gly Val Glu Arg Ile Leu Leu Ala Gly
570 575 580
gcg ccg aag agc ttt gag ggc agc gcg cat gcg ccc gat ggt tat ttg 1891
Ala Pro Lys Ser Phe Glu Gly Ser Ala His Ala Pro Asp Gly Tyr Leu
585 590 595
aac atg aca att gat gcc gcg gcg acg ctg gct gac ctg cta gat gct 1939
Asn Met Thr Ile Asp Ala Ala Ala Thr Leu Ala Asp Leu Leu Asp Ala
600 605 610
ttg gga gct taaatcatga cgtcgatccc taa 1971
Leu Gly Ala
615
<210> 184
<211> 616
<212> PRT
<213> Corynebacterium glutamicum
<400> 184
Leu Thr Asp Leu Thr Lys Thr Ala Val Pro Glu Glu Leu Ser Glu Asn
1 5 10 15
Leu Glu Thr Trp Tyr Lys Ala Val Ala Gly Val Phe Ala Arg Thr Gln
20 25 30
Lys Lys Asp Ile Gly Asp Ile Ala Val Asp Val Trp Lys Lys Leu Ile
35 40 45
Val Thr Thr Pro Asp Gly Val Asp Ile Asn Pro Leu Tyr Thr Arg Ala
50 55 60
Asp Glu Ser Gln Arg Lys Phe Thr Glu Val Pro Gly Glu Phe Pro Phe
65 70 75 80
Thr Arg Gly Thr Thr Val Asp Gly Glu Arg Val Gly Trp Gly Val Thr
85 90 95
Glu Thr Phe Gly His Asp Ser Pro Lys Asn Ile Asn Ala Ala Val Leu
100 105 110
Asn Ala Leu Asn Ser Gly Thr Thr Thr Leu Gly Phe Glu Phe Ser Glu
115 120 125
Glu Phe Thr Ala Ala Asp Leu Lys Val Ala Leu Glu Gly Val Tyr Leu
130 135 140
Asn Met Ala Pro Leu Leu Ile His Ala Gly Gly Ser Thr Ser Glu Val
145 150 155 160
Ala Ala Ala Leu Tyr Thr Leu Ala Glu Glu Ala Gly Thr Phe Phe Ala
165 170 175
Ala Leu Thr Leu Gly Ser Arg Pro Leu Thr Ala Gln Val Asp Gly Ser
180 185 190
His Ser Asp Thr Ile Glu Glu Ala Val Gln Leu Ala Val Asn Ala Ser
195 200 205
Lys Arg Ala Asn Val Arg Ala Ile Leu Val Asp Gly Ser Ser Phe Ser
210 215 220
Asn Gln Gly Ala Ser Asp Ala Gln Glu Ile Gly Leu Ser Ile Ala Ala
225 230 235 240
Gly Val Asp Tyr Val Arg Arg Leu Val Asp Ala Gly Leu Ser Thr Glu
245 250 255
Ala Ala Leu Lys Gln Val Ala Phe Arg Phe Ala Val Thr Asp Glu Gln
260 265 270
Phe Ala Gln Ile Ser Lys Leu Arg Val Ala Arg Arg Leu Trp Ala Arg
275 280 285
Val Cys Glu Val Leu Gly Phe Pro Glu Leu Ala Val Ala Pro Gln His
290 295 300
Ala Val Thr Ala Arg Ala Met Phe Ser Gln Arg Asp Pro Trp Val Asn
305 310 315 320
Met Leu Arg Ser Thr Val Ala Ala Phe Ala Ala Gly Val Gly Gly Ala
325 330 335
Thr Asp Val Glu Val Arg Thr Phe Asp Asp Ala Ile Pro Asp Gly Val
340 345 350
Pro Gly Val Ser Arg Asn Phe Ala His Arg Ile Ala Arg Asn Thr Asn
355 360 365
Leu Leu Leu Leu Glu Glu Ser His Leu Gly His Val Val Asp Pro Ala
370 375 380
Gly Gly Ser Tyr Phe Val Glu Ser Phe Thr Asp Asp Leu Ala Glu Lys
385 390 395 400
Ala Trp Ala Val Phe Ser Gly Ile Glu Ala Glu Gly Gly Tyr Ser Ala
405 410 415
Ala Cys Ala Ser Gly Thr Val Thr Ala Met Leu Asp Gln Thr Trp Glu
420 425 430
Gln Thr Arg Ala Asp Val Ala Ser Arg Lys Lys Lys Leu Thr Gly Ile
435 440 445
Asn Glu Phe Pro Asn Leu Ala Glu Ser Pro Leu Pro Ala Asp Arg Arg
450 455 460
Val Glu Pro Ala Gly Val Arg Arg Trp Ala Ala Asp Phe Glu Ala Leu
465 470 475 480
Arg Asn Arg Ser Asp Ala Phe Leu Glu Lys Asn Gly Ala Arg Pro Gln
485 490 495
Ile Thr Met Ile Pro Leu Gly Pro Leu Ser Lys His Asn Ile Arg Thr
500 505 510
Gly Phe Thr Ser Asn Leu Leu Ala Ser Gly Gly Ile Glu Ala Ile Asn
515 520 525
Pro Gly Gln Leu Val Pro Gly Thr Asp Ala Phe Ala Glu Ala Ala Gln
530 535 540
Ala Ala Gly Ile Val Val Val Cys Gly Thr Asp Gln Glu Tyr Ala Glu
545 550 555 560
Thr Gly Glu Gly Ala Val Glu Lys Leu Arg Glu Ala Gly Val Glu Arg
565 570 575
Ile Leu Leu Ala Gly Ala Pro Lys Ser Phe Glu Gly Ser Ala His Ala
580 585 590
Pro Asp Gly Tyr Leu Asn Met Thr Ile Asp Ala Ala Ala Thr Leu Ala
595 600 605
Asp Leu Leu Asp Ala Leu Gly Ala
610 615
<210> 185
<211> 1179
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1156)
<223> RXS02106
<400> 185
ggtcgccgct tttcgacgcc cgcctgcggc gggatgactg tgatggaggg gcgcgtcgac 60
aagcaaaatc tctttagcaa attcggttac tgtggggcgc atg aat aac cat ttt 115
Met Asn Asn His Phe
1 5
gag ctc aaa gta cct ggt gga aag ctt gtc gtc gtt gat gtg acc acc 163
Glu Leu Lys Val Pro Gly Gly Lys Leu Val Val Val Asp Val Thr Thr
10 15 20
gat ctg gat tcc att gct gac gtg aag att tcc ggc gat ttc ttc ctc 211
Asp Leu Asp Ser Ile Ala Asp Val Lys Ile Ser Gly Asp Phe Phe Leu
25 30 35
gaa ccc gat gag gca ttc ttc gcc ctt ggc cgg gcg ctg cag ggg gcg 259
Glu Pro Asp Glu Ala Phe Phe Ala Leu Gly Arg Ala Leu Gln Gly Ala
40 45 50
tcg gtg ggt gat aac act gat cgt ttg cag gca aag ttg gat gca gcg 307
Ser Val Gly Asp Asn Thr Asp Arg Leu Gln Ala Lys Leu Asp Ala Ala
55 60 65
ttg gcg gaa tat gat gac gtt gag cta cac ggc ttt agc act gcg gat 355
Leu Ala Glu Tyr Asp Asp Val Glu Leu His Gly Phe Ser Thr Ala Asp
70 75 80 85
att gct tta gct gtg cgt cgg gca gtc acc ggc gcg caa gat ttc acc 403
Ile Ala Leu Ala Val Arg Arg Ala Val Thr Gly Ala Gln Asp Phe Thr
90 95 100
gat tat gaa tgg gaa atc ctg cac cca ggg gtg ctt cct acc cca ctt 451
Asp Tyr Glu Trp Glu Ile Leu His Pro Gly Val Leu Pro Thr Pro Leu
105 110 115
aac gtt gcg ttg gat gag ctc ctt ttg gac caa gtt gcc agt ggt cag 499
Asn Val Ala Leu Asp Glu Leu Leu Leu Asp Gln Val Ala Ser Gly Gln
120 125 130
cgt ggc ccg acg atg cgc att tgg gat tgg gat gat cgc gcc aca gtg 547
Arg Gly Pro Thr Met Arg Ile Trp Asp Trp Asp Asp Arg Ala Thr Val
135 140 145
atc ggt agt ttc cag tca tat gtc aat gaa atc aac caa gaa ggc gtt 595
Ile Gly Ser Phe Gln Ser Tyr Val Asn Glu Ile Asn Gln Glu Gly Val
150 155 160 165
aat gaa cat ggt gtg acc gtg gta cga cgc atg tct ggt ggc ggt gca 643
Asn Glu His Gly Val Thr Val Val Arg Arg Met Ser Gly Gly Gly Ala
170 175 180
atg ttt atg gag ggc ggc aac tgc atc acc tat tcc ctg tat gca ccg 691
Met Phe Met Glu Gly Gly Asn Cys Ile Thr Tyr Ser Leu Tyr Ala Pro
185 190 195
gaa tct ctc gtt gct ggt ttg agc tat gag cag tcc tat gaa tat ttg 739
Glu Ser Leu Val Ala Gly Leu Ser Tyr Glu Gln Ser Tyr Glu Tyr Leu
200 205 210
gat cgt tgg gtg att gct gcg ctg aag aca cac gat gtt gac gct tgg 787
Asp Arg Trp Val Ile Ala Ala Leu Lys Thr His Asp Val Asp Ala Trp
215 220 225
tac gtg cct atc aat gac atc acc tcc acc ggc gga aaa atc ggt ggc 835
Tyr Val Pro Ile Asn Asp Ile Thr Ser Thr Gly Gly Lys Ile Gly Gly
230 235 240 245
gct gca cag aaa cgt cgc agt ggc gca gtc ctc cac cac gtg acc atg 883
Ala Ala Gln Lys Arg Arg Ser Gly Ala Val Leu His His Val Thr Met
250 255 260
tcc tat gac atc gat gcg gac atg atg acc cag gtg ttg cgc att gga 931
Ser Tyr Asp Ile Asp Ala Asp Met Met Thr Gln Val Leu Arg Ile Gly
265 270 275
aag gtg aag att tcc gac aag ggt ctt cgc agc gca aag aag cgc gtt 979
Lys Val Lys Ile Ser Asp Lys Gly Leu Arg Ser Ala Lys Lys Arg Val
280 285 290
gat cct ctg cgc cgc caa aca ggt gca tca cgt gag caa atc atc gac 1027
Asp Pro Leu Arg Arg Gln Thr Gly Ala Ser Arg Glu Gln Ile Ile Asp
295 300 305
acc cta aag tcc aca ttc agt gct agg tac ggc gcg caa gaa gta gag 1075
Thr Leu Lys Ser Thr Phe Ser Ala Arg Tyr Gly Ala Gln Glu Val Glu
310 315 320 325
ctc agc gat gaa gat ttc gcg gca ggc cac gac cta gta aaa acc aaa 1123
Leu Ser Asp Glu Asp Phe Ala Ala Gly His Asp Leu Val Lys Thr Lys
330 335 340
tac gcc acc gag gag tgg act aag cga gtt caa tagtttctat ggatctgcac 1176
Tyr Ala Thr Glu Glu Trp Thr Lys Arg Val Gln
345 350
aag 1179
<210> 186
<211> 352
<212> PRT
<213> Corynebacterium glutamicum
<400> 186
Met Asn Asn His Phe Glu Leu Lys Val Pro Gly Gly Lys Leu Val Val
1 5 10 15
Val Asp Val Thr Thr Asp Leu Asp Ser Ile Ala Asp Val Lys Ile Ser
20 25 30
Gly Asp Phe Phe Leu Glu Pro Asp Glu Ala Phe Phe Ala Leu Gly Arg
35 40 45
Ala Leu Gln Gly Ala Ser Val Gly Asp Asn Thr Asp Arg Leu Gln Ala
50 55 60
Lys Leu Asp Ala Ala Leu Ala Glu Tyr Asp Asp Val Glu Leu His Gly
65 70 75 80
Phe Ser Thr Ala Asp Ile Ala Leu Ala Val Arg Arg Ala Val Thr Gly
85 90 95
Ala Gln Asp Phe Thr Asp Tyr Glu Trp Glu Ile Leu His Pro Gly Val
100 105 110
Leu Pro Thr Pro Leu Asn Val Ala Leu Asp Glu Leu Leu Leu Asp Gln
115 120 125
Val Ala Ser Gly Gln Arg Gly Pro Thr Met Arg Ile Trp Asp Trp Asp
130 135 140
Asp Arg Ala Thr Val Ile Gly Ser Phe Gln Ser Tyr Val Asn Glu Ile
145 150 155 160
Asn Gln Glu Gly Val Asn Glu His Gly Val Thr Val Val Arg Arg Met
165 170 175
Ser Gly Gly Gly Ala Met Phe Met Glu Gly Gly Asn Cys Ile Thr Tyr
180 185 190
Ser Leu Tyr Ala Pro Glu Ser Leu Val Ala Gly Leu Ser Tyr Glu Gln
195 200 205
Ser Tyr Glu Tyr Leu Asp Arg Trp Val Ile Ala Ala Leu Lys Thr His
210 215 220
Asp Val Asp Ala Trp Tyr Val Pro Ile Asn Asp Ile Thr Ser Thr Gly
225 230 235 240
Gly Lys Ile Gly Gly Ala Ala Gln Lys Arg Arg Ser Gly Ala Val Leu
245 250 255
His His Val Thr Met Ser Tyr Asp Ile Asp Ala Asp Met Met Thr Gln
260 265 270
Val Leu Arg Ile Gly Lys Val Lys Ile Ser Asp Lys Gly Leu Arg Ser
275 280 285
Ala Lys Lys Arg Val Asp Pro Leu Arg Arg Gln Thr Gly Ala Ser Arg
290 295 300
Glu Gln Ile Ile Asp Thr Leu Lys Ser Thr Phe Ser Ala Arg Tyr Gly
305 310 315 320
Ala Gln Glu Val Glu Leu Ser Asp Glu Asp Phe Ala Ala Gly His Asp
325 330 335
Leu Val Lys Thr Lys Tyr Ala Thr Glu Glu Trp Thr Lys Arg Val Gln
340 345 350
<210> 187
<211> 876
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(853)
<223> RXS01746
<400> 187
aaaccgccac tcccctttca ctggggagtg gcggttttgt cgtttcatgc atgcagtgtg 60
tgacttatca accttgttag ggctagggtg gatatctatc atg act gca cca aga 115
Met Thr Ala Pro Arg
1 5
gat cct ttt ttc ccc gca gat ctt tct atc cgc gcg tct gca gag ccc 163
Asp Pro Phe Phe Pro Ala Asp Leu Ser Ile Arg Ala Ser Ala Glu Pro
10 15 20
att gaa att cag cgg ttg ggt ttg atc gat tat caa gag gcc tgg gat 211
Ile Glu Ile Gln Arg Leu Gly Leu Ile Asp Tyr Gln Glu Ala Trp Asp
25 30 35
tat caa gca gag ctt gct acc cgt agg gct aat gat gaa atc cct gat 259
Tyr Gln Ala Glu Leu Ala Thr Arg Arg Ala Asn Asp Glu Ile Pro Asp
40 45 50
cag ctg ctt att ttg gag cac ccg tcg gtg tat acc gca ggt aag cgc 307
Gln Leu Leu Ile Leu Glu His Pro Ser Val Tyr Thr Ala Gly Lys Arg
55 60 65
acc cag ccg gaa gat ctt ccc acc aac gga ctg ccg gtg atc aat gct 355
Thr Gln Pro Glu Asp Leu Pro Thr Asn Gly Leu Pro Val Ile Asn Ala
70 75 80 85
gat cgt ggt ggt cgc atc acg tgg cat ggt cct ggc caa ttg gtg atc 403
Asp Arg Gly Gly Arg Ile Thr Trp His Gly Pro Gly Gln Leu Val Ile
90 95 100
tat ccg atc atc aaa tta gcc gat ccg atc gat gtg gtt gat tac gta 451
Tyr Pro Ile Ile Lys Leu Ala Asp Pro Ile Asp Val Val Asp Tyr Val
105 110 115
aga cgc ctc gag gaa gcg ctc atc caa gtt gtc ggc gat atg ggt gtt 499
Arg Arg Leu Glu Glu Ala Leu Ile Gln Val Val Gly Asp Met Gly Val
120 125 130
gcc ggc gct ggg cgc att gat ggg cgt tcg ggt gtg tgg gtg cca gct 547
Ala Gly Ala Gly Arg Ile Asp Gly Arg Ser Gly Val Trp Val Pro Ala
135 140 145
cat gat ggt tgg gtg gac agc aag gtt gcg gcc atc ggc att cga ata 595
His Asp Gly Trp Val Asp Ser Lys Val Ala Ala Ile Gly Ile Arg Ile
150 155 160 165
act cgt ggt gtt gca atg cac ggt gtg gcc atc aac tgc aac aac acg 643
Thr Arg Gly Val Ala Met His Gly Val Ala Ile Asn Cys Asn Asn Thr
170 175 180
ttg gat ttc tat gag cac atc att ccg tgt ggc att gct gat gca ggc 691
Leu Asp Phe Tyr Glu His Ile Ile Pro Cys Gly Ile Ala Asp Ala Gly
185 190 195
ttg agc aca ctc tcg agg gaa ctg aaa agg gac gtt tca gtt gag gaa 739
Leu Ser Thr Leu Ser Arg Glu Leu Lys Arg Asp Val Ser Val Glu Glu
200 205 210
tta gtc gag cca tcg atc cgc gca ttg gat gat gct ttg gct ggt cgg 787
Leu Val Glu Pro Ser Ile Arg Ala Leu Asp Asp Ala Leu Ala Gly Arg
215 220 225
ctg gtt gtt tct gat cat tct ttc ggc agc gcg ccc gac cca act aag 835
Leu Val Val Ser Asp His Ser Phe Gly Ser Ala Pro Asp Pro Thr Lys
230 235 240 245
aat ctc cct aaa cgg ggg tagtacgagg aattttgtcg gtg 876
Asn Leu Pro Lys Arg Gly
250
<210> 188
<211> 251
<212> PRT
<213> Corynebacterium glutamicum
<400> 188
Met Thr Ala Pro Arg Asp Pro Phe Phe Pro Ala Asp Leu Ser Ile Arg
1 5 10 15
Ala Ser Ala Glu Pro Ile Glu Ile Gln Arg Leu Gly Leu Ile Asp Tyr
20 25 30
Gln Glu Ala Trp Asp Tyr Gln Ala Glu Leu Ala Thr Arg Arg Ala Asn
35 40 45
Asp Glu Ile Pro Asp Gln Leu Leu Ile Leu Glu His Pro Ser Val Tyr
50 55 60
Thr Ala Gly Lys Arg Thr Gln Pro Glu Asp Leu Pro Thr Asn Gly Leu
65 70 75 80
Pro Val Ile Asn Ala Asp Arg Gly Gly Arg Ile Thr Trp His Gly Pro
85 90 95
Gly Gln Leu Val Ile Tyr Pro Ile Ile Lys Leu Ala Asp Pro Ile Asp
100 105 110
Val Val Asp Tyr Val Arg Arg Leu Glu Glu Ala Leu Ile Gln Val Val
115 120 125
Gly Asp Met Gly Val Ala Gly Ala Gly Arg Ile Asp Gly Arg Ser Gly
130 135 140
Val Trp Val Pro Ala His Asp Gly Trp Val Asp Ser Lys Val Ala Ala
145 150 155 160
Ile Gly Ile Arg Ile Thr Arg Gly Val Ala Met His Gly Val Ala Ile
165 170 175
Asn Cys Asn Asn Thr Leu Asp Phe Tyr Glu His Ile Ile Pro Cys Gly
180 185 190
Ile Ala Asp Ala Gly Leu Ser Thr Leu Ser Arg Glu Leu Lys Arg Asp
195 200 205
Val Ser Val Glu Glu Leu Val Glu Pro Ser Ile Arg Ala Leu Asp Asp
210 215 220
Ala Leu Ala Gly Arg Leu Val Val Ser Asp His Ser Phe Gly Ser Ala
225 230 235 240
Pro Asp Pro Thr Lys Asn Leu Pro Lys Arg Gly
245 250
<210> 189
<211> 1167
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1144)
<223> RXS01747
<400> 189
cgaagtagag ccgattgcag aatcggcgga atgagacgtc gaaaagcgtt taagctttcc 60
ctaaaaatat cactaactcg aaagatgtaa ggttgcattt gtg act atc gca cct 115
Val Thr Ile Ala Pro
1 5
gaa gga cga cga ctg cta cgc gtc gaa gct cga aac tca gaa acc ccg 163
Glu Gly Arg Arg Leu Leu Arg Val Glu Ala Arg Asn Ser Glu Thr Pro
10 15 20
att gag acg aag cct cga tgg att aga aac cag gtc aaa aac gga cct 211
Ile Glu Thr Lys Pro Arg Trp Ile Arg Asn Gln Val Lys Asn Gly Pro
25 30 35
gag tat cag gat atg aag gaa cgt gtc gct ggc gca tca cta cac act 259
Glu Tyr Gln Asp Met Lys Glu Arg Val Ala Gly Ala Ser Leu His Thr
40 45 50
gtg tgt cag gag gct ggc tgt cct aat atc cat gag tgt tgg gaa tcc 307
Val Cys Gln Glu Ala Gly Cys Pro Asn Ile His Glu Cys Trp Glu Ser
55 60 65
cgt gag gca acc ttc ctc att ggt ggc gcc aac tgc tct cgc cgc tgt 355
Arg Glu Ala Thr Phe Leu Ile Gly Gly Ala Asn Cys Ser Arg Arg Cys
70 75 80 85
gat ttc tgc atg atc aac tcg gct cgc cct gag cca ctc gac cgc ggt 403
Asp Phe Cys Met Ile Asn Ser Ala Arg Pro Glu Pro Leu Asp Arg Gly
90 95 100
gag cca ctg cgt gtc gct gag tct gtt cgt gag atg cag ctg aat tac 451
Glu Pro Leu Arg Val Ala Glu Ser Val Arg Glu Met Gln Leu Asn Tyr
105 110 115
tcc acc atc acc ggt gtt acc cgt gat gat ctg gat gat gaa ggc gca 499
Ser Thr Ile Thr Gly Val Thr Arg Asp Asp Leu Asp Asp Glu Gly Ala
120 125 130
tgg ctg tac tca gaa gtg gtt cgt aag atc cac gag ctg aac cca cac 547
Trp Leu Tyr Ser Glu Val Val Arg Lys Ile His Glu Leu Asn Pro His
135 140 145
acc ggt gtg gaa aac ctg gtg cct gat ttc tcc ggc aag aag gat ctg 595
Thr Gly Val Glu Asn Leu Val Pro Asp Phe Ser Gly Lys Lys Asp Leu
150 155 160 165
ctg cag gaa gtt ttt gaa tcc cgc cca gag gtt ttc gct cac aac gtg 643
Leu Gln Glu Val Phe Glu Ser Arg Pro Glu Val Phe Ala His Asn Val
170 175 180
gaa act gtg cca cgt att ttc aag cgc att cgc cca gca ttc cgc tac 691
Glu Thr Val Pro Arg Ile Phe Lys Arg Ile Arg Pro Ala Phe Arg Tyr
185 190 195
gag cgt tca ctt gat gtg atc cgt cag gct cgc gat ttc ggt ctg gtg 739
Glu Arg Ser Leu Asp Val Ile Arg Gln Ala Arg Asp Phe Gly Leu Val
200 205 210
acc aag tcc aac ctg att ttg ggc atg ggt gaa acc aag gaa gaa atc 787
Thr Lys Ser Asn Leu Ile Leu Gly Met Gly Glu Thr Lys Glu Glu Ile
215 220 225
acc gag gcg ctg cag gat ctg cac gac gct ggc tgt gac atc atc acc 835
Thr Glu Ala Leu Gln Asp Leu His Asp Ala Gly Cys Asp Ile Ile Thr
230 235 240 245
atc acc cag tac ctg cgt cct ggt cct ttg ttc cac ccc atc gag cgt 883
Ile Thr Gln Tyr Leu Arg Pro Gly Pro Leu Phe His Pro Ile Glu Arg
250 255 260
tgg gtg aag cct gag gag ttc ctc gag cac gct gat gct gca aag gaa 931
Trp Val Lys Pro Glu Glu Phe Leu Glu His Ala Asp Ala Ala Lys Glu
265 270 275
atg ggc ttc gct gct gtt atg tcc ggc cca ttg gtt cgt tcc tct tac 979
Met Gly Phe Ala Ala Val Met Ser Gly Pro Leu Val Arg Ser Ser Tyr
280 285 290
cgt gca ggc cgt ctg tac gcg cag gcc atg gag ttc cgt ggc gag gaa 1027
Arg Ala Gly Arg Leu Tyr Ala Gln Ala Met Glu Phe Arg Gly Glu Glu
295 300 305
atc cca gca cac ctc gcg cac ctg aag gat act tcc gga gga tcc acc 1075
Ile Pro Ala His Leu Ala His Leu Lys Asp Thr Ser Gly Gly Ser Thr
310 315 320 325
gcc cag gaa gca tct aca ctt ctg gag cgt tac ggt gct tcc gaa gac 1123
Ala Gln Glu Ala Ser Thr Leu Leu Glu Arg Tyr Gly Ala Ser Glu Asp
330 335 340
acc cca gtg gtg tcc ttc aac taagcccgaa gttttttaac cgc 1167
Thr Pro Val Val Ser Phe Asn
345
<210> 190
<211> 348
<212> PRT
<213> Corynebacterium glutamicum
<400> 190
Val Thr Ile Ala Pro Glu Gly Arg Arg Leu Leu Arg Val Glu Ala Arg
1 5 10 15
Asn Ser Glu Thr Pro Ile Glu Thr Lys Pro Arg Trp Ile Arg Asn Gln
20 25 30
Val Lys Asn Gly Pro Glu Tyr Gln Asp Met Lys Glu Arg Val Ala Gly
35 40 45
Ala Ser Leu His Thr Val Cys Gln Glu Ala Gly Cys Pro Asn Ile His
50 55 60
Glu Cys Trp Glu Ser Arg Glu Ala Thr Phe Leu Ile Gly Gly Ala Asn
65 70 75 80
Cys Ser Arg Arg Cys Asp Phe Cys Met Ile Asn Ser Ala Arg Pro Glu
85 90 95
Pro Leu Asp Arg Gly Glu Pro Leu Arg Val Ala Glu Ser Val Arg Glu
100 105 110
Met Gln Leu Asn Tyr Ser Thr Ile Thr Gly Val Thr Arg Asp Asp Leu
115 120 125
Asp Asp Glu Gly Ala Trp Leu Tyr Ser Glu Val Val Arg Lys Ile His
130 135 140
Glu Leu Asn Pro His Thr Gly Val Glu Asn Leu Val Pro Asp Phe Ser
145 150 155 160
Gly Lys Lys Asp Leu Leu Gln Glu Val Phe Glu Ser Arg Pro Glu Val
165 170 175
Phe Ala His Asn Val Glu Thr Val Pro Arg Ile Phe Lys Arg Ile Arg
180 185 190
Pro Ala Phe Arg Tyr Glu Arg Ser Leu Asp Val Ile Arg Gln Ala Arg
195 200 205
Asp Phe Gly Leu Val Thr Lys Ser Asn Leu Ile Leu Gly Met Gly Glu
210 215 220
Thr Lys Glu Glu Ile Thr Glu Ala Leu Gln Asp Leu His Asp Ala Gly
225 230 235 240
Cys Asp Ile Ile Thr Ile Thr Gln Tyr Leu Arg Pro Gly Pro Leu Phe
245 250 255
His Pro Ile Glu Arg Trp Val Lys Pro Glu Glu Phe Leu Glu His Ala
260 265 270
Asp Ala Ala Lys Glu Met Gly Phe Ala Ala Val Met Ser Gly Pro Leu
275 280 285
Val Arg Ser Ser Tyr Arg Ala Gly Arg Leu Tyr Ala Gln Ala Met Glu
290 295 300
Phe Arg Gly Glu Glu Ile Pro Ala His Leu Ala His Leu Lys Asp Thr
305 310 315 320
Ser Gly Gly Ser Thr Ala Gln Glu Ala Ser Thr Leu Leu Glu Arg Tyr
325 330 335
Gly Ala Ser Glu Asp Thr Pro Val Val Ser Phe Asn
340 345
<210> 191
<211> 903
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(880)
<223> RXC01748
<400> 191
atcaccaaat gtggcggttt tgcgtcgaaa agcgtgctct ttctacacct ctttgaggtt 60
cattttcgcg gtttcctcac aatcgcctat tgttaagtac atg gca gac gcg aaa 115
Met Ala Asp Ala Lys
1 5
aag cag gcg gat aaa gcc gcc aag aag cag gta aga gca gcc aag aag 163
Lys Gln Ala Asp Lys Ala Ala Lys Lys Gln Val Arg Ala Ala Lys Lys
10 15 20
gca cag cgc aag gag act cgc tca caa atg tgg cag gtc ttc aac atg 211
Ala Gln Arg Lys Glu Thr Arg Ser Gln Met Trp Gln Val Phe Asn Met
25 30 35
caa cgc aag cag gat aag gct ctt att ccg ctt ctg ttg ctc gct att 259
Gln Arg Lys Gln Asp Lys Ala Leu Ile Pro Leu Leu Leu Leu Ala Ile
40 45 50
ctt ggt atc ccg ctg gtc ctt ttc ctc atc ggt ttg att tgg ggt ggt 307
Leu Gly Ile Pro Leu Val Leu Phe Leu Ile Gly Leu Ile Trp Gly Gly
55 60 65
cag tgg tgg atg ctt ccg atc ggc att gct gca ggt gtt gta gct gca 355
Gln Trp Trp Met Leu Pro Ile Gly Ile Ala Ala Gly Val Val Ala Ala
70 75 80 85
atg ttt att ttc acc cgt cgc gtt gag cgt gac gtg tac aag cgc gcc 403
Met Phe Ile Phe Thr Arg Arg Val Glu Arg Asp Val Tyr Lys Arg Ala
90 95 100
gaa ggt cag cag ggt gct gct ggt tgg gct gtg gag aac ctc cgc tct 451
Glu Gly Gln Gln Gly Ala Ala Gly Trp Ala Val Glu Asn Leu Arg Ser
105 110 115
ggc gtg ggc atg acc tgg cgc acc aag acc gct gtt gca gtg acc act 499
Gly Val Gly Met Thr Trp Arg Thr Lys Thr Ala Val Ala Val Thr Thr
120 125 130
cag atg gat gca gtg cac cgc gtc att ggt ctg tgt ggt gtt gtg ctg 547
Gln Met Asp Ala Val His Arg Val Ile Gly Leu Cys Gly Val Val Leu
135 140 145
gtc ggc gag ggc tcc cct cac cgc ctg aag cca atg ctt gcg cag caa 595
Val Gly Glu Gly Ser Pro His Arg Leu Lys Pro Met Leu Ala Gln Gln
150 155 160 165
aag aag cgc ctg aac cgc gtg gca cct ggt gtt cca gtg tat gaa atc 643
Lys Lys Arg Leu Asn Arg Val Ala Pro Gly Val Pro Val Tyr Glu Ile
170 175 180
atc acg ggc aac ggc gaa ggc cag acc cct atc gcg aag ctg cag cgt 691
Ile Thr Gly Asn Gly Glu Gly Gln Thr Pro Ile Ala Lys Leu Gln Arg
185 190 195
gaa ctg gtc aag ctg cct cgc aac tac aag aag aac gac gtc gct gcc 739
Glu Leu Val Lys Leu Pro Arg Asn Tyr Lys Lys Asn Asp Val Ala Ala
200 205 210
ctg gcc gct cgc att gag gct atg gac aat gtc gga aac gct cct ggc 787
Leu Ala Ala Arg Ile Glu Ala Met Asp Asn Val Gly Asn Ala Pro Gly
215 220 225
gga tct ttg cct aag ggt cca ttg cca aag ggc gca agc atg tcc ggt 835
Gly Ser Leu Pro Lys Gly Pro Leu Pro Lys Gly Ala Ser Met Ser Gly
230 235 240 245
atg aac cgc cgc gct cgc cga cag gct gaa cgc aag ggc gag gct 880
Met Asn Arg Arg Ala Arg Arg Gln Ala Glu Arg Lys Gly Glu Ala
250 255 260
taaagccttt tcgctttcgc gtc 903
<210> 192
<211> 260
<212> PRT
<213> Corynebacterium glutamicum
<400> 192
Met Ala Asp Ala Lys Lys Gln Ala Asp Lys Ala Ala Lys Lys Gln Val
1 5 10 15
Arg Ala Ala Lys Lys Ala Gln Arg Lys Glu Thr Arg Ser Gln Met Trp
20 25 30
Gln Val Phe Asn Met Gln Arg Lys Gln Asp Lys Ala Leu Ile Pro Leu
35 40 45
Leu Leu Leu Ala Ile Leu Gly Ile Pro Leu Val Leu Phe Leu Ile Gly
50 55 60
Leu Ile Trp Gly Gly Gln Trp Trp Met Leu Pro Ile Gly Ile Ala Ala
65 70 75 80
Gly Val Val Ala Ala Met Phe Ile Phe Thr Arg Arg Val Glu Arg Asp
85 90 95
Val Tyr Lys Arg Ala Glu Gly Gln Gln Gly Ala Ala Gly Trp Ala Val
100 105 110
Glu Asn Leu Arg Ser Gly Val Gly Met Thr Trp Arg Thr Lys Thr Ala
115 120 125
Val Ala Val Thr Thr Gln Met Asp Ala Val His Arg Val Ile Gly Leu
130 135 140
Cys Gly Val Val Leu Val Gly Glu Gly Ser Pro His Arg Leu Lys Pro
145 150 155 160
Met Leu Ala Gln Gln Lys Lys Arg Leu Asn Arg Val Ala Pro Gly Val
165 170 175
Pro Val Tyr Glu Ile Ile Thr Gly Asn Gly Glu Gly Gln Thr Pro Ile
180 185 190
Ala Lys Leu Gln Arg Glu Leu Val Lys Leu Pro Arg Asn Tyr Lys Lys
195 200 205
Asn Asp Val Ala Ala Leu Ala Ala Arg Ile Glu Ala Met Asp Asn Val
210 215 220
Gly Asn Ala Pro Gly Gly Ser Leu Pro Lys Gly Pro Leu Pro Lys Gly
225 230 235 240
Ala Ser Met Ser Gly Met Asn Arg Arg Ala Arg Arg Gln Ala Glu Arg
245 250 255
Lys Gly Glu Ala
260
<210> 193
<211> 936
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(913)
<223> RXC00354
<400> 193
ggcttgtcgg taaggctgca gggtagcggg agtttccttc agattggaag ttctttaatt 60
ttctcgatta tgtacctcat ttacgcgtaa agtttggggc atg gga aag tta ctt 115
Met Gly Lys Leu Leu
1 5
ttc gta gac atc ggt ggc aca ctg ctg gat tac tca aat gaa gtt ccg 163
Phe Val Asp Ile Gly Gly Thr Leu Leu Asp Tyr Ser Asn Glu Val Pro
10 15 20
cgt tcg gcc gtt gac gcg atc cgt aag gca cgc gcc aaa gga cac cgc 211
Arg Ser Ala Val Asp Ala Ile Arg Lys Ala Arg Ala Lys Gly His Arg
25 30 35
gtg tac ttg agc tct ggt cga agc agc gct gag gtg act tct cag ttg 259
Val Tyr Leu Ser Ser Gly Arg Ser Ser Ala Glu Val Thr Ser Gln Leu
40 45 50
tgg gat atc gga gtg gat ggc ctc att ggc gca aat ggt gga tat gtg 307
Trp Asp Ile Gly Val Asp Gly Leu Ile Gly Ala Asn Gly Gly Tyr Val
55 60 65
gaa agc gca cag gag tct gtg ttc cac cgc cgt ttg tcg ggt gag gag 355
Glu Ser Ala Gln Glu Ser Val Phe His Arg Arg Leu Ser Gly Glu Glu
70 75 80 85
acc cgc cac att gtg gag tgg ctc tac aac cgt ggt ttg gag ttt tat 403
Thr Arg His Ile Val Glu Trp Leu Tyr Asn Arg Gly Leu Glu Phe Tyr
90 95 100
ctc gag tcc aac aac ggt ttg tat gca agc cgt ggt ttc cgt gag gct 451
Leu Glu Ser Asn Asn Gly Leu Tyr Ala Ser Arg Gly Phe Arg Glu Ala
105 110 115
tct aag cca gtg ctg tct cgc ctt tcg gag aag acc gac gtg aca gtc 499
Ser Lys Pro Val Leu Ser Arg Leu Ser Glu Lys Thr Asp Val Thr Val
120 125 130
gat agc atg tac ccg gat atg ttc tgg ggc gcg agc ctt gat cgt gac 547
Asp Ser Met Tyr Pro Asp Met Phe Trp Gly Ala Ser Leu Asp Arg Asp
135 140 145
gat gtg aac aag atc agt tac atc ttc aat tct cag gaa gat ttg gac 595
Asp Val Asn Lys Ile Ser Tyr Ile Phe Asn Ser Gln Glu Asp Leu Asp
150 155 160 165
gca gcg cgt gag gcg ttc cct aac ctg gag cac acc acg tgg ggt ggt 643
Ala Ala Arg Glu Ala Phe Pro Asn Leu Glu His Thr Thr Trp Gly Gly
170 175 180
cag acg ggt gcg ttg ttc ggc acg atc ggt gtg tct gtc aac aag aag 691
Gln Thr Gly Ala Leu Phe Gly Thr Ile Gly Val Ser Val Asn Lys Lys
185 190 195
atc ggc gtg gat cgc ctg ctg aag tac ctg aac gca gat cgc gca aac 739
Ile Gly Val Asp Arg Leu Leu Lys Tyr Leu Asn Ala Asp Arg Ala Asn
200 205 210
acc att gcg ttc ggc gac agc gat gag gat ctc tcc cta ttt gag gcg 787
Thr Ile Ala Phe Gly Asp Ser Asp Glu Asp Leu Ser Leu Phe Glu Ala
215 220 225
agc gct tac ggc gtc gcg atg ggc gag gcc acc gaa tcg ctc aag gct 835
Ser Ala Tyr Gly Val Ala Met Gly Glu Ala Thr Glu Ser Leu Lys Ala
230 235 240 245
gct gct gac ctg gtc acg gat gct gtt ggg cag gac ggc ttg cgc aat 883
Ala Ala Asp Leu Val Thr Asp Ala Val Gly Gln Asp Gly Leu Arg Asn
250 255 260
gcg ttt tta aag ctt gag ctt atc gac gcc tgaccccatc aaagaacttc 933
Ala Phe Leu Lys Leu Glu Leu Ile Asp Ala
265 270
cca 936
<210> 194
<211> 271
<212> PRT
<213> Corynebacterium glutamicum
<400> 194
Met Gly Lys Leu Leu Phe Val Asp Ile Gly Gly Thr Leu Leu Asp Tyr
1 5 10 15
Ser Asn Glu Val Pro Arg Ser Ala Val Asp Ala Ile Arg Lys Ala Arg
20 25 30
Ala Lys Gly His Arg Val Tyr Leu Ser Ser Gly Arg Ser Ser Ala Glu
35 40 45
Val Thr Ser Gln Leu Trp Asp Ile Gly Val Asp Gly Leu Ile Gly Ala
50 55 60
Asn Gly Gly Tyr Val Glu Ser Ala Gln Glu Ser Val Phe His Arg Arg
65 70 75 80
Leu Ser Gly Glu Glu Thr Arg His Ile Val Glu Trp Leu Tyr Asn Arg
85 90 95
Gly Leu Glu Phe Tyr Leu Glu Ser Asn Asn Gly Leu Tyr Ala Ser Arg
100 105 110
Gly Phe Arg Glu Ala Ser Lys Pro Val Leu Ser Arg Leu Ser Glu Lys
115 120 125
Thr Asp Val Thr Val Asp Ser Met Tyr Pro Asp Met Phe Trp Gly Ala
130 135 140
Ser Leu Asp Arg Asp Asp Val Asn Lys Ile Ser Tyr Ile Phe Asn Ser
145 150 155 160
Gln Glu Asp Leu Asp Ala Ala Arg Glu Ala Phe Pro Asn Leu Glu His
165 170 175
Thr Thr Trp Gly Gly Gln Thr Gly Ala Leu Phe Gly Thr Ile Gly Val
180 185 190
Ser Val Asn Lys Lys Ile Gly Val Asp Arg Leu Leu Lys Tyr Leu Asn
195 200 205
Ala Asp Arg Ala Asn Thr Ile Ala Phe Gly Asp Ser Asp Glu Asp Leu
210 215 220
Ser Leu Phe Glu Ala Ser Ala Tyr Gly Val Ala Met Gly Glu Ala Thr
225 230 235 240
Glu Ser Leu Lys Ala Ala Ala Asp Leu Val Thr Asp Ala Val Gly Gln
245 250 255
Asp Gly Leu Arg Asn Ala Phe Leu Lys Leu Glu Leu Ile Asp Ala
260 265 270
<210> 195
<211> 1740
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1717)
<223> RXC01749
<400> 195
ggtttttgcg tgctctggtt tagggactgg ttttgggaac gtgcccagtt ccacatcaaa 60
taacgctgag gtcgtactta atccatgaga tcatgaatgg gtg agc ttc ctt gta 115
Val Ser Phe Leu Val
1 5
gaa aat caa tta ctc gcg ttg gtt gtc atc atg acg gtc gga cta ttg 163
Glu Asn Gln Leu Leu Ala Leu Val Val Ile Met Thr Val Gly Leu Leu
10 15 20
ctc ggc cgc atc aaa att ttc ggg ttc cgt ctc ggc gtc gcc gct gta 211
Leu Gly Arg Ile Lys Ile Phe Gly Phe Arg Leu Gly Val Ala Ala Val
25 30 35
ctg ttt gta ggt cta gcg cta tcc acc att gag ccg gat att tcc gtc 259
Leu Phe Val Gly Leu Ala Leu Ser Thr Ile Glu Pro Asp Ile Ser Val
40 45 50
cca tcc ctc att tac gtg gtt gga ctg tcg ctt ttt gtc tac acg atc 307
Pro Ser Leu Ile Tyr Val Val Gly Leu Ser Leu Phe Val Tyr Thr Ile
55 60 65
ggt ctg gaa gcc ggc cct gga ttc ttc acc tcc atg aaa acc act ggt 355
Gly Leu Glu Ala Gly Pro Gly Phe Phe Thr Ser Met Lys Thr Thr Gly
70 75 80 85
ctg cgc aac aac gca ctg acc ttg ggc gcc atc atc gcc acc acg gca 403
Leu Arg Asn Asn Ala Leu Thr Leu Gly Ala Ile Ile Ala Thr Thr Ala
90 95 100
ctc gca tgg gca ctc atc aca gtt ttg aac atc gat gcc gcc tcc ggc 451
Leu Ala Trp Ala Leu Ile Thr Val Leu Asn Ile Asp Ala Ala Ser Gly
105 110 115
gcc ggc atg ctc acc ggc gcg ctc acc aac acc cca gcc atg gcc gca 499
Ala Gly Met Leu Thr Gly Ala Leu Thr Asn Thr Pro Ala Met Ala Ala
120 125 130
gtt gtt gac gca ctt cct tcg ctt atc gac gac acc ggc cag ctt cac 547
Val Val Asp Ala Leu Pro Ser Leu Ile Asp Asp Thr Gly Gln Leu His
135 140 145
ctc atc gcc gag ctg ccc gtc gtc gca tat tcc ttg gca tac ccc ctc 595
Leu Ile Ala Glu Leu Pro Val Val Ala Tyr Ser Leu Ala Tyr Pro Leu
150 155 160 165
ggt gtg ctc atc gtt att ctc tcc atc gcc atc ttc agc tct gtg ttc 643
Gly Val Leu Ile Val Ile Leu Ser Ile Ala Ile Phe Ser Ser Val Phe
170 175 180
aaa gtc gac cac aac aaa gaa gcc gaa gaa gcg ggc gtt gcg gtc cag 691
Lys Val Asp His Asn Lys Glu Ala Glu Glu Ala Gly Val Ala Val Gln
185 190 195
gaa ctc aaa ggc cgt cgc atc cgc gtc acc gtc gct gat ctt cca gcc 739
Glu Leu Lys Gly Arg Arg Ile Arg Val Thr Val Ala Asp Leu Pro Ala
200 205 210
ctg gag aac atc cca gag ctg ctc aac ctc cac gtc att gtg tcc cga 787
Leu Glu Asn Ile Pro Glu Leu Leu Asn Leu His Val Ile Val Ser Arg
215 220 225
gtg gaa cga gac ggt gag caa ttc atc ccg ctt tat ggc gaa cac gca 835
Val Glu Arg Asp Gly Glu Gln Phe Ile Pro Leu Tyr Gly Glu His Ala
230 235 240 245
cgc atc ggc gat gtc tta aca gtg gtg ggt gcc gat gaa gaa ctc aac 883
Arg Ile Gly Asp Val Leu Thr Val Val Gly Ala Asp Glu Glu Leu Asn
250 255 260
cgc gcg gaa aaa gcc atc ggt gaa ctc att gac ggc gac ccc tac agc 931
Arg Ala Glu Lys Ala Ile Gly Glu Leu Ile Asp Gly Asp Pro Tyr Ser
265 270 275
aat gtg gaa ctt gat tac cga cgc atc ttc gtc tca aac aca gca gtc 979
Asn Val Glu Leu Asp Tyr Arg Arg Ile Phe Val Ser Asn Thr Ala Val
280 285 290
gtg ggc act ccc cta tcc aag ctc cag cca ctg ttt aaa gac atg ctg 1027
Val Gly Thr Pro Leu Ser Lys Leu Gln Pro Leu Phe Lys Asp Met Leu
295 300 305
atc acc cgc atc agg cgc ggc gac aca gat ttg gtg gcc tcc tcc gac 1075
Ile Thr Arg Ile Arg Arg Gly Asp Thr Asp Leu Val Ala Ser Ser Asp
310 315 320 325
atg act ttg cag ctc ggt gac cgt gtc cgc gtt gtc gca cca gca gaa 1123
Met Thr Leu Gln Leu Gly Asp Arg Val Arg Val Val Ala Pro Ala Glu
330 335 340
aaa ctc cgc gaa gca acc caa ttg ctc ggc gat tcc tac aag aaa ctc 1171
Lys Leu Arg Glu Ala Thr Gln Leu Leu Gly Asp Ser Tyr Lys Lys Leu
345 350 355
tcc gat ttc aac ctg ctc cca ctc gct gcc ggc ctc atg atc ggt gtg 1219
Ser Asp Phe Asn Leu Leu Pro Leu Ala Ala Gly Leu Met Ile Gly Val
360 365 370
ctt gtc ggc atg gtg gag ttc cca cta cca ggt gga agc tcc ctg aaa 1267
Leu Val Gly Met Val Glu Phe Pro Leu Pro Gly Gly Ser Ser Leu Lys
375 380 385
ctg ggt aac gca ggt gga ccg cta gtt gtt gcg ctg ctg ctc ggc atg 1315
Leu Gly Asn Ala Gly Gly Pro Leu Val Val Ala Leu Leu Leu Gly Met
390 395 400 405
atc aat cgc aca ggc aag ttc gtc tgg caa atc ccc tac gga gca aac 1363
Ile Asn Arg Thr Gly Lys Phe Val Trp Gln Ile Pro Tyr Gly Ala Asn
410 415 420
ctt gcc ctt cgc caa ctg ggc atc aca cta ttt ttg gct gcc atc ggt 1411
Leu Ala Leu Arg Gln Leu Gly Ile Thr Leu Phe Leu Ala Ala Ile Gly
425 430 435
acc tca gcg ggc gca gga ttt cga tca gcg atc agc gac ccc caa tca 1459
Thr Ser Ala Gly Ala Gly Phe Arg Ser Ala Ile Ser Asp Pro Gln Ser
440 445 450
ctc acc atc atc ggc ttc ggt gcg ctg ctc act ttg ttc atc tcc atc 1507
Leu Thr Ile Ile Gly Phe Gly Ala Leu Leu Thr Leu Phe Ile Ser Ile
455 460 465
acg gtg ctg ttc gtt ggc cac aaa ctg atg aaa atc ccc ttc ggt gaa 1555
Thr Val Leu Phe Val Gly His Lys Leu Met Lys Ile Pro Phe Gly Glu
470 475 480 485
acc gct ggc atc ctc gcc ggt acg caa acc cac cct gct gtg ctg agt 1603
Thr Ala Gly Ile Leu Ala Gly Thr Gln Thr His Pro Ala Val Leu Ser
490 495 500
tat gtg tca gat gcc tcc cgc aac gag ctc cct gcc atg ggt tat acc 1651
Tyr Val Ser Asp Ala Ser Arg Asn Glu Leu Pro Ala Met Gly Tyr Thr
505 510 515
tct gtg tat ccg ctg gcg atg atc gca aag atc ctg gcc gcc caa acg 1699
Ser Val Tyr Pro Leu Ala Met Ile Ala Lys Ile Leu Ala Ala Gln Thr
520 525 530
ttg ttg ttc cta ctt atc tagcattgac cccttaagcg cag 1740
Leu Leu Phe Leu Leu Ile
535
<210> 196
<211> 539
<212> PRT
<213> Corynebacterium glutamicum
<400> 196
Val Ser Phe Leu Val Glu Asn Gln Leu Leu Ala Leu Val Val Ile Met
1 5 10 15
Thr Val Gly Leu Leu Leu Gly Arg Ile Lys Ile Phe Gly Phe Arg Leu
20 25 30
Gly Val Ala Ala Val Leu Phe Val Gly Leu Ala Leu Ser Thr Ile Glu
35 40 45
Pro Asp Ile Ser Val Pro Ser Leu Ile Tyr Val Val Gly Leu Ser Leu
50 55 60
Phe Val Tyr Thr Ile Gly Leu Glu Ala Gly Pro Gly Phe Phe Thr Ser
65 70 75 80
Met Lys Thr Thr Gly Leu Arg Asn Asn Ala Leu Thr Leu Gly Ala Ile
85 90 95
Ile Ala Thr Thr Ala Leu Ala Trp Ala Leu Ile Thr Val Leu Asn Ile
100 105 110
Asp Ala Ala Ser Gly Ala Gly Met Leu Thr Gly Ala Leu Thr Asn Thr
115 120 125
Pro Ala Met Ala Ala Val Val Asp Ala Leu Pro Ser Leu Ile Asp Asp
130 135 140
Thr Gly Gln Leu His Leu Ile Ala Glu Leu Pro Val Val Ala Tyr Ser
145 150 155 160
Leu Ala Tyr Pro Leu Gly Val Leu Ile Val Ile Leu Ser Ile Ala Ile
165 170 175
Phe Ser Ser Val Phe Lys Val Asp His Asn Lys Glu Ala Glu Glu Ala
180 185 190
Gly Val Ala Val Gln Glu Leu Lys Gly Arg Arg Ile Arg Val Thr Val
195 200 205
Ala Asp Leu Pro Ala Leu Glu Asn Ile Pro Glu Leu Leu Asn Leu His
210 215 220
Val Ile Val Ser Arg Val Glu Arg Asp Gly Glu Gln Phe Ile Pro Leu
225 230 235 240
Tyr Gly Glu His Ala Arg Ile Gly Asp Val Leu Thr Val Val Gly Ala
245 250 255
Asp Glu Glu Leu Asn Arg Ala Glu Lys Ala Ile Gly Glu Leu Ile Asp
260 265 270
Gly Asp Pro Tyr Ser Asn Val Glu Leu Asp Tyr Arg Arg Ile Phe Val
275 280 285
Ser Asn Thr Ala Val Val Gly Thr Pro Leu Ser Lys Leu Gln Pro Leu
290 295 300
Phe Lys Asp Met Leu Ile Thr Arg Ile Arg Arg Gly Asp Thr Asp Leu
305 310 315 320
Val Ala Ser Ser Asp Met Thr Leu Gln Leu Gly Asp Arg Val Arg Val
325 330 335
Val Ala Pro Ala Glu Lys Leu Arg Glu Ala Thr Gln Leu Leu Gly Asp
340 345 350
Ser Tyr Lys Lys Leu Ser Asp Phe Asn Leu Leu Pro Leu Ala Ala Gly
355 360 365
Leu Met Ile Gly Val Leu Val Gly Met Val Glu Phe Pro Leu Pro Gly
370 375 380
Gly Ser Ser Leu Lys Leu Gly Asn Ala Gly Gly Pro Leu Val Val Ala
385 390 395 400
Leu Leu Leu Gly Met Ile Asn Arg Thr Gly Lys Phe Val Trp Gln Ile
405 410 415
Pro Tyr Gly Ala Asn Leu Ala Leu Arg Gln Leu Gly Ile Thr Leu Phe
420 425 430
Leu Ala Ala Ile Gly Thr Ser Ala Gly Ala Gly Phe Arg Ser Ala Ile
435 440 445
Ser Asp Pro Gln Ser Leu Thr Ile Ile Gly Phe Gly Ala Leu Leu Thr
450 455 460
Leu Phe Ile Ser Ile Thr Val Leu Phe Val Gly His Lys Leu Met Lys
465 470 475 480
Ile Pro Phe Gly Glu Thr Ala Gly Ile Leu Ala Gly Thr Gln Thr His
485 490 495
Pro Ala Val Leu Ser Tyr Val Ser Asp Ala Ser Arg Asn Glu Leu Pro
500 505 510
Ala Met Gly Tyr Thr Ser Val Tyr Pro Leu Ala Met Ile Ala Lys Ile
515 520 525
Leu Ala Ala Gln Thr Leu Leu Phe Leu Leu Ile
530 535
<210> 197
<211> 1023
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1000)
<223> RXA02268
<400> 197
tgaatcgttg gtgcttcgag ttgggattgt tatgtgggga gacgtcgata agcaaaacac 60
ttgccgagcg caagccggcc tacggcgcta gtgtgagcac atg tcc cag gaa aat 115
Met Ser Gln Glu Asn
1 5
tct ggt ttg ttc aag cgc gcg att aca cgt ggg gtg gct aag gtg cgc 163
Ser Gly Leu Phe Lys Arg Ala Ile Thr Arg Gly Val Ala Lys Val Arg
10 15 20
cgg aat ccg cgc gag gat ttt gcg gag gaa ttc acc caa gaa ctc tac 211
Arg Asn Pro Arg Glu Asp Phe Ala Glu Glu Phe Thr Gln Glu Leu Tyr
25 30 35
gat cac gca aca aat atc acc ctg ccc ctg acg gcg cgg ctg aag ccg 259
Asp His Ala Thr Asn Ile Thr Leu Pro Leu Thr Ala Arg Leu Lys Pro
40 45 50
aat ggg ttt ttc cag gat gat tgg cgg gcg cga cca agt ggt gcg cga 307
Asn Gly Phe Phe Gln Asp Asp Trp Arg Ala Arg Pro Ser Gly Ala Arg
55 60 65
ccg tgg ccg atc gtg cta att cac gga tcc ggg gcc agc aag ggt tca 355
Pro Trp Pro Ile Val Leu Ile His Gly Ser Gly Ala Ser Lys Gly Ser
70 75 80 85
tgg gag gaa atg ggc gct gag ctg cgc agc aaa ggt tgg gcc gtg ttt 403
Trp Glu Glu Met Gly Ala Glu Leu Arg Ser Lys Gly Trp Ala Val Phe
90 95 100
gcc cct gac ttt gga acg cgt gcc acc gag cca att gcg gcg tcg gct 451
Ala Pro Asp Phe Gly Thr Arg Ala Thr Glu Pro Ile Ala Ala Ser Ala
105 110 115
gcc caa att ggt gcg tat att gat gcc gtt ttg ttg gtg acg ggc gct 499
Ala Gln Ile Gly Ala Tyr Ile Asp Ala Val Leu Leu Val Thr Gly Ala
120 125 130
gcg cag att gtg ctg gtt ggg cat tcg caa ggc ggt gtc gtg gcg cgg 547
Ala Gln Ile Val Leu Val Gly His Ser Gln Gly Gly Val Val Ala Arg
135 140 145
tat tgg atg cgc acc tac ggc gga tac atg aag gtc agg cac atg att 595
Tyr Trp Met Arg Thr Tyr Gly Gly Tyr Met Lys Val Arg His Met Ile
150 155 160 165
tcc atc tct acg cca aat cac gga acg ctc atg gga ggc att tta aac 643
Ser Ile Ser Thr Pro Asn His Gly Thr Leu Met Gly Gly Ile Leu Asn
170 175 180
ccg atg acg aag gtg aaa tcg gga gag gga acg atc gaa aag ctg atg 691
Pro Met Thr Lys Val Lys Ser Gly Glu Gly Thr Ile Glu Lys Leu Met
185 190 195
cac aga cta ttc ggg ccc act ggt ttt gaa cag ctg cgc gga cac gac 739
His Arg Leu Phe Gly Pro Thr Gly Phe Glu Gln Leu Arg Gly His Asp
200 205 210
atc atc gag ttt ttg gcc gac ggt ggg gac ctc gat cca ggc gtc acc 787
Ile Ile Glu Phe Leu Ala Asp Gly Gly Asp Leu Asp Pro Gly Val Thr
215 220 225
tac acc tgc att ggt acc cat ttt gat cct ttc atc caa cct ccg gag 835
Tyr Thr Cys Ile Gly Thr His Phe Asp Pro Phe Ile Gln Pro Pro Glu
230 235 240 245
gtg gcc ttt ttg gag gtc aac gag gac gat gat cca aat cga gtc cac 883
Val Ala Phe Leu Glu Val Asn Glu Asp Asp Asp Pro Asn Arg Val His
250 255 260
aat att tgg gtc gaa gat gaa cac ccg cgc gca atg att gcc cac aac 931
Asn Ile Trp Val Glu Asp Glu His Pro Arg Ala Met Ile Ala His Asn
265 270 275
gat atg gtg cgc gat ccc agg gtg atc gaa atc gta cgc gca gag ctc 979
Asp Met Val Arg Asp Pro Arg Val Ile Glu Ile Val Arg Ala Glu Leu
280 285 290
gac cgg gtg gca cgc ctc ggc taagttgggg acatggttga cgc 1023
Asp Arg Val Ala Arg Leu Gly
295 300
<210> 198
<211> 300
<212> PRT
<213> Corynebacterium glutamicum
<400> 198
Met Ser Gln Glu Asn Ser Gly Leu Phe Lys Arg Ala Ile Thr Arg Gly
1 5 10 15
Val Ala Lys Val Arg Arg Asn Pro Arg Glu Asp Phe Ala Glu Glu Phe
20 25 30
Thr Gln Glu Leu Tyr Asp His Ala Thr Asn Ile Thr Leu Pro Leu Thr
35 40 45
Ala Arg Leu Lys Pro Asn Gly Phe Phe Gln Asp Asp Trp Arg Ala Arg
50 55 60
Pro Ser Gly Ala Arg Pro Trp Pro Ile Val Leu Ile His Gly Ser Gly
65 70 75 80
Ala Ser Lys Gly Ser Trp Glu Glu Met Gly Ala Glu Leu Arg Ser Lys
85 90 95
Gly Trp Ala Val Phe Ala Pro Asp Phe Gly Thr Arg Ala Thr Glu Pro
100 105 110
Ile Ala Ala Ser Ala Ala Gln Ile Gly Ala Tyr Ile Asp Ala Val Leu
115 120 125
Leu Val Thr Gly Ala Ala Gln Ile Val Leu Val Gly His Ser Gln Gly
130 135 140
Gly Val Val Ala Arg Tyr Trp Met Arg Thr Tyr Gly Gly Tyr Met Lys
145 150 155 160
Val Arg His Met Ile Ser Ile Ser Thr Pro Asn His Gly Thr Leu Met
165 170 175
Gly Gly Ile Leu Asn Pro Met Thr Lys Val Lys Ser Gly Glu Gly Thr
180 185 190
Ile Glu Lys Leu Met His Arg Leu Phe Gly Pro Thr Gly Phe Glu Gln
195 200 205
Leu Arg Gly His Asp Ile Ile Glu Phe Leu Ala Asp Gly Gly Asp Leu
210 215 220
Asp Pro Gly Val Thr Tyr Thr Cys Ile Gly Thr His Phe Asp Pro Phe
225 230 235 240
Ile Gln Pro Pro Glu Val Ala Phe Leu Glu Val Asn Glu Asp Asp Asp
245 250 255
Pro Asn Arg Val His Asn Ile Trp Val Glu Asp Glu His Pro Arg Ala
260 265 270
Met Ile Ala His Asn Asp Met Val Arg Asp Pro Arg Val Ile Glu Ile
275 280 285
Val Arg Ala Glu Leu Asp Arg Val Ala Arg Leu Gly
290 295 300
<210> 199
<211> 1095
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1072)
<223> RXA02269
<400> 199
cgcaatgatt gcccacaacg atatggtgcg cgatcccagg gtgatcgaaa tcgtacgcgc 60
agagctcgac cgggtggcac gcctcggcta agttggggac atg gtt gac gcc ctc 115
Met Val Asp Ala Leu
1 5
aat gat ctc cgc cga gaa ctc aca aac gcg tta agg tcc gtg tgg aaa 163
Asn Asp Leu Arg Arg Glu Leu Thr Asn Ala Leu Arg Ser Val Trp Lys
10 15 20
aac ctc ccc act gat aac gcc ccg cag gcc gat gcc ttg cca gac gat 211
Asn Leu Pro Thr Asp Asn Ala Pro Gln Ala Asp Ala Leu Pro Asp Asp
25 30 35
gta gtg gaa gag att gcg ata aat ttc tac cgt gat ccc aaa aac cgc 259
Val Val Glu Glu Ile Ala Ile Asn Phe Tyr Arg Asp Pro Lys Asn Arg
40 45 50
ggc aaa ctc aac gaa gac aaa aca gat tcc ttg ccg atg ctc gcg cgc 307
Gly Lys Leu Asn Glu Asp Lys Thr Asp Ser Leu Pro Met Leu Ala Arg
55 60 65
ata cgt tca cgt gga ctt ttt gaa gac gat tgg cgc gcc cgc ccc acc 355
Ile Arg Ser Arg Gly Leu Phe Glu Asp Asp Trp Arg Ala Arg Pro Thr
70 75 80 85
gaa gac cgc ccc tgg cca gtg gta tta gtc cac gga act gga tca aca 403
Glu Asp Arg Pro Trp Pro Val Val Leu Val His Gly Thr Gly Ser Thr
90 95 100
aaa ggt gat tgg caa gac ttg gga gcc gat cta cgc cgc gac ggc tgg 451
Lys Gly Asp Trp Gln Asp Leu Gly Ala Asp Leu Arg Arg Asp Gly Trp
105 110 115
gca gtg ttt gca ccc gaa ttt ggc caa cgc gcc acc ggt tca gtc gca 499
Ala Val Phe Ala Pro Glu Phe Gly Gln Arg Ala Thr Gly Ser Val Ala
120 125 130
gaa tca tcc gca caa att ggc gcc tat ata gat aca gta ttg ctt gct 547
Glu Ser Ser Ala Gln Ile Gly Ala Tyr Ile Asp Thr Val Leu Leu Ala
135 140 145
aca gga gcc tca aaa gtc att gtc gtt ggc cac tcc caa ggc ggc gtg 595
Thr Gly Ala Ser Lys Val Ile Val Val Gly His Ser Gln Gly Gly Val
150 155 160 165
ttg ctg aga tac tgg atg cgt gtt ttg ggt ggt gca tcc aaa gtc aaa 643
Leu Leu Arg Tyr Trp Met Arg Val Leu Gly Gly Ala Ser Lys Val Lys
170 175 180
cac atg gtc tcc ctc gct gtc ccc aat cac ggc acc acc atg ggc gga 691
His Met Val Ser Leu Ala Val Pro Asn His Gly Thr Thr Met Gly Gly
185 190 195
atc gtc agc ccg cta atc cgt aac aat cgt ggc gaa agt gtg gtt aat 739
Ile Val Ser Pro Leu Ile Arg Asn Asn Arg Gly Glu Ser Val Val Asn
200 205 210
tct gtc gtt caa tca tgg ttc ggc gaa gct gga ttt gaa atg atc cgc 787
Ser Val Val Gln Ser Trp Phe Gly Glu Ala Gly Phe Glu Met Ile Arg
215 220 225
gga cac gac acc atc aac gcc atc aat gaa ggc ggc gat ttg gat cca 835
Gly His Asp Thr Ile Asn Ala Ile Asn Glu Gly Gly Asp Leu Asp Pro
230 235 240 245
gac gtg aca tat ctg tgc atc gcc acc cac ttt gac acc gtg att cag 883
Asp Val Thr Tyr Leu Cys Ile Ala Thr His Phe Asp Thr Val Ile Gln
250 255 260
ccc cct gaa acc tgc ttc cta gag gcc cgg aac ccc gaa gaa ctc aag 931
Pro Pro Glu Thr Cys Phe Leu Glu Ala Arg Asn Pro Glu Glu Leu Lys
265 270 275
cgg gtc caa aac atc tgg gtg gaa aac ctc gac ccc aat tca gtc gtg 979
Arg Val Gln Asn Ile Trp Val Glu Asn Leu Asp Pro Asn Ser Val Val
280 285 290
ctc cac gaa gca atg cct tac gat ccc cgc gta cgc gca ctg gtc agg 1027
Leu His Glu Ala Met Pro Tyr Asp Pro Arg Val Arg Ala Leu Val Arg
295 300 305
gcg gat ttg agc aaa ttg gtg gag att tcc gag act gcg gag aac 1072
Ala Asp Leu Ser Lys Leu Val Glu Ile Ser Glu Thr Ala Glu Asn
310 315 320
taggggtttt ggtggttgtc taa 1095
<210> 200
<211> 324
<212> PRT
<213> Corynebacterium glutamicum
<400> 200
Met Val Asp Ala Leu Asn Asp Leu Arg Arg Glu Leu Thr Asn Ala Leu
1 5 10 15
Arg Ser Val Trp Lys Asn Leu Pro Thr Asp Asn Ala Pro Gln Ala Asp
20 25 30
Ala Leu Pro Asp Asp Val Val Glu Glu Ile Ala Ile Asn Phe Tyr Arg
35 40 45
Asp Pro Lys Asn Arg Gly Lys Leu Asn Glu Asp Lys Thr Asp Ser Leu
50 55 60
Pro Met Leu Ala Arg Ile Arg Ser Arg Gly Leu Phe Glu Asp Asp Trp
65 70 75 80
Arg Ala Arg Pro Thr Glu Asp Arg Pro Trp Pro Val Val Leu Val His
85 90 95
Gly Thr Gly Ser Thr Lys Gly Asp Trp Gln Asp Leu Gly Ala Asp Leu
100 105 110
Arg Arg Asp Gly Trp Ala Val Phe Ala Pro Glu Phe Gly Gln Arg Ala
115 120 125
Thr Gly Ser Val Ala Glu Ser Ser Ala Gln Ile Gly Ala Tyr Ile Asp
130 135 140
Thr Val Leu Leu Ala Thr Gly Ala Ser Lys Val Ile Val Val Gly His
145 150 155 160
Ser Gln Gly Gly Val Leu Leu Arg Tyr Trp Met Arg Val Leu Gly Gly
165 170 175
Ala Ser Lys Val Lys His Met Val Ser Leu Ala Val Pro Asn His Gly
180 185 190
Thr Thr Met Gly Gly Ile Val Ser Pro Leu Ile Arg Asn Asn Arg Gly
195 200 205
Glu Ser Val Val Asn Ser Val Val Gln Ser Trp Phe Gly Glu Ala Gly
210 215 220
Phe Glu Met Ile Arg Gly His Asp Thr Ile Asn Ala Ile Asn Glu Gly
225 230 235 240
Gly Asp Leu Asp Pro Asp Val Thr Tyr Leu Cys Ile Ala Thr His Phe
245 250 255
Asp Thr Val Ile Gln Pro Pro Glu Thr Cys Phe Leu Glu Ala Arg Asn
260 265 270
Pro Glu Glu Leu Lys Arg Val Gln Asn Ile Trp Val Glu Asn Leu Asp
275 280 285
Pro Asn Ser Val Val Leu His Glu Ala Met Pro Tyr Asp Pro Arg Val
290 295 300
Arg Ala Leu Val Arg Ala Asp Leu Ser Lys Leu Val Glu Ile Ser Glu
305 310 315 320
Thr Ala Glu Asn
<210> 201
<211> 1146
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1123)
<223> RXA01614
<400> 201
tgcaattcgc aaacatgagt agtatcgcgg aagtttcacc acgtgaacat ttcagtcgac 60
tcgcgcacac cacaccaaca atcgacctat cgttatacgt atg aat cag atg cag 115
Met Asn Gln Met Gln
1 5
cag tgg aaa cca gac ttc ctg gga gag ggc tac caa aac ctc acc atc 163
Gln Trp Lys Pro Asp Phe Leu Gly Glu Gly Tyr Gln Asn Leu Thr Ile
10 15 20
gag ctc ggc gac gac ccg gat aat gaa aca gat gtt gtg aca acg gtt 211
Glu Leu Gly Asp Asp Pro Asp Asn Glu Thr Asp Val Val Thr Thr Val
25 30 35
gtg cgc tac aac cca gac aat cac gcg gac gag tct ttt gct gcc cgc 259
Val Arg Tyr Asn Pro Asp Asn His Ala Asp Glu Ser Phe Ala Ala Arg
40 45 50
cca gcg ttg ctg tgg gtt cac ggc atg acg gac tac ttc ttc cac act 307
Pro Ala Leu Leu Trp Val His Gly Met Thr Asp Tyr Phe Phe His Thr
55 60 65
gaa ttc gcg gag ttt ttc cac aat gcc ggt ttt gct gtg tac ggc att 355
Glu Phe Ala Glu Phe Phe His Asn Ala Gly Phe Ala Val Tyr Gly Ile
70 75 80 85
gat ctt aga aaa tgt gga cgc tcc tac cgt cca gga cag cag tgg cac 403
Asp Leu Arg Lys Cys Gly Arg Ser Tyr Arg Pro Gly Gln Gln Trp His
90 95 100
tac acc tct gat ctt gcc cat tac ttc cct gac tta aca gct gct gcc 451
Tyr Thr Ser Asp Leu Ala His Tyr Phe Pro Asp Leu Thr Ala Ala Ala
105 110 115
gag gtc atc tct tcc acc cac cct gag cta gtc ccc gtc gcc cat tcc 499
Glu Val Ile Ser Ser Thr His Pro Glu Leu Val Pro Val Ala His Ser
120 125 130
act ggt gga ctc atc gtt cct ctg tgg atg tcc cag atg cgc aca agc 547
Thr Gly Gly Leu Ile Val Pro Leu Trp Met Ser Gln Met Arg Thr Ser
135 140 145
aat cca gct gcc att gag aag att cca gcg ctg gtc ctc aac agt ccg 595
Asn Pro Ala Ala Ile Glu Lys Ile Pro Ala Leu Val Leu Asn Ser Pro
150 155 160 165
tgg ctg gac atg atg tat cca cca ctg ttc atc aag ctg atc acc cct 643
Trp Leu Asp Met Met Tyr Pro Pro Leu Phe Ile Lys Leu Ile Thr Pro
170 175 180
atg gtg agg gtg ttg ggc aaa cgc tcc ccc aca acc atc atc cca ggc 691
Met Val Arg Val Leu Gly Lys Arg Ser Pro Thr Thr Ile Ile Pro Gly
185 190 195
gga ggt ttg gga gca tac gga aaa tcg atc cat aag aac ttt tac ggc 739
Gly Gly Leu Gly Ala Tyr Gly Lys Ser Ile His Lys Asn Phe Tyr Gly
200 205 210
gaa tgg gac ttt gac acc acc atc aag cct gta gaa gga cat aaa aag 787
Glu Trp Asp Phe Asp Thr Thr Ile Lys Pro Val Glu Gly His Lys Lys
215 220 225
agc atc gga tgg ctt cgg gca gtc atg gct ggc caa gca gaa atc cat 835
Ser Ile Gly Trp Leu Arg Ala Val Met Ala Gly Gln Ala Glu Ile His
230 235 240 245
cac gac cac gtg aat gtc gga gtg gac gtg ctc acg ctg tgt tca aat 883
His Asp His Val Asn Val Gly Val Asp Val Leu Thr Leu Cys Ser Asn
250 255 260
aag tcc tgg ttg aag tct gaa tac aca gag gac acc aac act tca gac 931
Lys Ser Trp Leu Lys Ser Glu Tyr Thr Glu Asp Thr Asn Thr Ser Asp
265 270 275
gcg gtt ttg gat gtg aaa cac att caa aag tgg gct cct cat ttg agc 979
Ala Val Leu Asp Val Lys His Ile Gln Lys Trp Ala Pro His Leu Ser
280 285 290
tcg cca tcg tcc agg gtt gat gtt gag atc atc gac aac gct cgc cac 1027
Ser Pro Ser Ser Arg Val Asp Val Glu Ile Ile Asp Asn Ala Arg His
295 300 305
gat att ttc ctc tca agg aaa ccc gcc aga gat cac gcc tct gaa gta 1075
Asp Ile Phe Leu Ser Arg Lys Pro Ala Arg Asp His Ala Ser Glu Val
310 315 320 325
ctc aac aac tgg ctg caa tcg aag ctt tcc agc ctc aaa cca tct caa 1123
Leu Asn Asn Trp Leu Gln Ser Lys Leu Ser Ser Leu Lys Pro Ser Gln
330 335 340
taacaccgcg aattatagac tga 1146
<210> 202
<211> 341
<212> PRT
<213> Corynebacterium glutamicum
<400> 202
Met Asn Gln Met Gln Gln Trp Lys Pro Asp Phe Leu Gly Glu Gly Tyr
1 5 10 15
Gln Asn Leu Thr Ile Glu Leu Gly Asp Asp Pro Asp Asn Glu Thr Asp
20 25 30
Val Val Thr Thr Val Val Arg Tyr Asn Pro Asp Asn His Ala Asp Glu
35 40 45
Ser Phe Ala Ala Arg Pro Ala Leu Leu Trp Val His Gly Met Thr Asp
50 55 60
Tyr Phe Phe His Thr Glu Phe Ala Glu Phe Phe His Asn Ala Gly Phe
65 70 75 80
Ala Val Tyr Gly Ile Asp Leu Arg Lys Cys Gly Arg Ser Tyr Arg Pro
85 90 95
Gly Gln Gln Trp His Tyr Thr Ser Asp Leu Ala His Tyr Phe Pro Asp
100 105 110
Leu Thr Ala Ala Ala Glu Val Ile Ser Ser Thr His Pro Glu Leu Val
115 120 125
Pro Val Ala His Ser Thr Gly Gly Leu Ile Val Pro Leu Trp Met Ser
130 135 140
Gln Met Arg Thr Ser Asn Pro Ala Ala Ile Glu Lys Ile Pro Ala Leu
145 150 155 160
Val Leu Asn Ser Pro Trp Leu Asp Met Met Tyr Pro Pro Leu Phe Ile
165 170 175
Lys Leu Ile Thr Pro Met Val Arg Val Leu Gly Lys Arg Ser Pro Thr
180 185 190
Thr Ile Ile Pro Gly Gly Gly Leu Gly Ala Tyr Gly Lys Ser Ile His
195 200 205
Lys Asn Phe Tyr Gly Glu Trp Asp Phe Asp Thr Thr Ile Lys Pro Val
210 215 220
Glu Gly His Lys Lys Ser Ile Gly Trp Leu Arg Ala Val Met Ala Gly
225 230 235 240
Gln Ala Glu Ile His His Asp His Val Asn Val Gly Val Asp Val Leu
245 250 255
Thr Leu Cys Ser Asn Lys Ser Trp Leu Lys Ser Glu Tyr Thr Glu Asp
260 265 270
Thr Asn Thr Ser Asp Ala Val Leu Asp Val Lys His Ile Gln Lys Trp
275 280 285
Ala Pro His Leu Ser Ser Pro Ser Ser Arg Val Asp Val Glu Ile Ile
290 295 300
Asp Asn Ala Arg His Asp Ile Phe Leu Ser Arg Lys Pro Ala Arg Asp
305 310 315 320
His Ala Ser Glu Val Leu Asn Asn Trp Leu Gln Ser Lys Leu Ser Ser
325 330 335
Leu Lys Pro Ser Gln
340
<210> 203
<211> 630
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(607)
<223> RXA01983
<400> 203
atatcgctgc catggcagcc ttgctgggca acctcaagca cactgaccta gaagagctcc 60
ccaccgatta ccaggggtgt cctcccatgt ccgctgcgtt atg gaa ggc tac gga 115
Met Glu Gly Tyr Gly
1 5
cct acc cag atc gaa aag ctc tta cct gca tac aca cag gtc aac aca 163
Pro Thr Gln Ile Glu Lys Leu Leu Pro Ala Tyr Thr Gln Val Asn Thr
10 15 20
gcc ggg aat aat cca gcg acg acg cct gag caa gat ctc ctc ggc gga 211
Ala Gly Asn Asn Pro Ala Thr Thr Pro Glu Gln Asp Leu Leu Gly Gly
25 30 35
gct gca acc tcg ccg gaa aac tac gac cac cag ctg cag tac gca gtc 259
Ala Ala Thr Ser Pro Glu Asn Tyr Asp His Gln Leu Gln Tyr Ala Val
40 45 50
gac gcc agt ccg gtg cat cag aat gcg gca cag gca ccg ccc ttc ctg 307
Asp Ala Ser Pro Val His Gln Asn Ala Ala Gln Ala Pro Pro Phe Leu
55 60 65
atc atg cac ggc act ggt gac cgg atg gtc cct ccg gag caa tcg gct 355
Ile Met His Gly Thr Gly Asp Arg Met Val Pro Pro Glu Gln Ser Ala
70 75 80 85
gcg ctg cac acc cat ctt gtg cag gct ggt cgg cag tcc acc ctg gta 403
Ala Leu His Thr His Leu Val Gln Ala Gly Arg Gln Ser Thr Leu Val
90 95 100
ctc att gag ggc ttt ggc cac ggt ttc ctc aat ccc ggg gaa gtc gcg 451
Leu Ile Glu Gly Phe Gly His Gly Phe Leu Asn Pro Gly Glu Val Ala
105 110 115
gag ctg ggg cca aac gtt cga cta gac aat ggt cgg ctc gag cgg gag 499
Glu Leu Gly Pro Asn Val Arg Leu Asp Asn Gly Arg Leu Glu Arg Glu
120 125 130
cct cag aca aat ttc agc gcg cag cag agt ccg gga aac ccc ttt gaa 547
Pro Gln Thr Asn Phe Ser Ala Gln Gln Ser Pro Gly Asn Pro Phe Glu
135 140 145
cta cag gga ctt gcc gcc gac cat gag atg atc aag cgc ttt ttc acc 595
Leu Gln Gly Leu Ala Ala Asp His Glu Met Ile Lys Arg Phe Phe Thr
150 155 160 165
ctg cac ctt cgc taagactcta ccttcaccca act 630
Leu His Leu Arg
<210> 204
<211> 169
<212> PRT
<213> Corynebacterium glutamicum
<400> 204
Met Glu Gly Tyr Gly Pro Thr Gln Ile Glu Lys Leu Leu Pro Ala Tyr
1 5 10 15
Thr Gln Val Asn Thr Ala Gly Asn Asn Pro Ala Thr Thr Pro Glu Gln
20 25 30
Asp Leu Leu Gly Gly Ala Ala Thr Ser Pro Glu Asn Tyr Asp His Gln
35 40 45
Leu Gln Tyr Ala Val Asp Ala Ser Pro Val His Gln Asn Ala Ala Gln
50 55 60
Ala Pro Pro Phe Leu Ile Met His Gly Thr Gly Asp Arg Met Val Pro
65 70 75 80
Pro Glu Gln Ser Ala Ala Leu His Thr His Leu Val Gln Ala Gly Arg
85 90 95
Gln Ser Thr Leu Val Leu Ile Glu Gly Phe Gly His Gly Phe Leu Asn
100 105 110
Pro Gly Glu Val Ala Glu Leu Gly Pro Asn Val Arg Leu Asp Asn Gly
115 120 125
Arg Leu Glu Arg Glu Pro Gln Thr Asn Phe Ser Ala Gln Gln Ser Pro
130 135 140
Gly Asn Pro Phe Glu Leu Gln Gly Leu Ala Ala Asp His Glu Met Ile
145 150 155 160
Lys Arg Phe Phe Thr Leu His Leu Arg
165
<210> 205
<211> 1414
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1414)
<223> RXN02947
<400> 205
gtatgttcac acaagaaccc tgcacaacgc cttcaaagta cgtcgaccac gaccaagcgc 60
attattcact ctcacccttc aggatttaga ctaagaaacc atg act gca gca cag 115
Met Thr Ala Ala Gln
1 5
acc aaa cct gac ctc acc acc acg gct gga aag ctg tcc gat ctt cgc 163
Thr Lys Pro Asp Leu Thr Thr Thr Ala Gly Lys Leu Ser Asp Leu Arg
10 15 20
tcc cgt ctt gca gaa gct caa gct cca atg ggc gaa gca act gta gaa 211
Ser Arg Leu Ala Glu Ala Gln Ala Pro Met Gly Glu Ala Thr Val Glu
25 30 35
aaa gtg cac gct gct ggc agg aag act gcc cgc gaa cgt atc gag tat 259
Lys Val His Ala Ala Gly Arg Lys Thr Ala Arg Glu Arg Ile Glu Tyr
40 45 50
ttg ctc gat gag ggc tct ttc gta gag atc gat gct ctt gct cgt cac 307
Leu Leu Asp Glu Gly Ser Phe Val Glu Ile Asp Ala Leu Ala Arg His
55 60 65
cgt tcc aag aac ttc ggc ctg gat gcc aag cgt cca gtt act gac ggt 355
Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg Pro Val Thr Asp Gly
70 75 80 85
gtt gtg act ggt tac ggc acc atc gat ggc cgt aag gtc tgt gtg ttc 403
Val Val Thr Gly Tyr Gly Thr Ile Asp Gly Arg Lys Val Cys Val Phe
90 95 100
tcc cag gac ggc gct gta ttc ggt ggc gct ttg ggt gaa gtt tat ggt 451
Ser Gln Asp Gly Ala Val Phe Gly Gly Ala Leu Gly Glu Val Tyr Gly
105 110 115
gaa aag atc gtt aag gtt atg gat ctt gcg atc aag acc ggt gtg cct 499
Glu Lys Ile Val Lys Val Met Asp Leu Ala Ile Lys Thr Gly Val Pro
120 125 130
ttg atc gga atc aat gag ggt gct ggt gcg cgt atc cag gaa ggt gtt 547
Leu Ile Gly Ile Asn Glu Gly Ala Gly Ala Arg Ile Gln Glu Gly Val
135 140 145
gtg tct ctg ggt ctg tac tca cag atc ttc tac cgc aac acc cag gcg 595
Val Ser Leu Gly Leu Tyr Ser Gln Ile Phe Tyr Arg Asn Thr Gln Ala
150 155 160 165
tct ggc gtt atc cca cag atc tct ttg atc atg ggt gcc tgc gct ggt 643
Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met Gly Ala Cys Ala Gly
170 175 180
ggt cac gtg tac tcc cct gct ctg act gac ttc atc gtc atg gtg gat 691
Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe Ile Val Met Val Asp
185 190 195
cag act tcc aag atg ttt atc acc ggc cct gat gtc atc aag act gtc 739
Gln Thr Ser Lys Met Phe Ile Thr Gly Pro Asp Val Ile Lys Thr Val
200 205 210
acc ggt gaa gat gtc acc cag gag gag ctc ggt ggc gct cac acc cac 787
Thr Gly Glu Asp Val Thr Gln Glu Glu Leu Gly Gly Ala His Thr His
215 220 225
atg gct acc tcc ggt acc tcc cat tac tct gct tct gat gat tca gat 835
Met Ala Thr Ser Gly Thr Ser His Tyr Ser Ala Ser Asp Asp Ser Asp
230 235 240 245
gct ttg gat tgg gtt cgc gag ctg acc tct tat ctt cca tcc aac aac 883
Ala Leu Asp Trp Val Arg Glu Leu Thr Ser Tyr Leu Pro Ser Asn Asn
250 255 260
cgt gcg gaa act cct cgc cag gag gcc gac atc atg atc ggt tcc atc 931
Arg Ala Glu Thr Pro Arg Gln Glu Ala Asp Ile Met Ile Gly Ser Ile
265 270 275
cag gaa aac atc aac gat gtg gat ctg gaa ttg gac acc atc atc ccg 979
Gln Glu Asn Ile Asn Asp Val Asp Leu Glu Leu Asp Thr Ile Ile Pro
280 285 290
gat tcc ccg aac cag cct tat gac atg aag gaa gtt att tcc cgc atc 1027
Asp Ser Pro Asn Gln Pro Tyr Asp Met Lys Glu Val Ile Ser Arg Ile
295 300 305
gtc gac gac gcc gag ttc ttc gag atc cag gaa gac tac gca gag aac 1075
Val Asp Asp Ala Glu Phe Phe Glu Ile Gln Glu Asp Tyr Ala Glu Asn
310 315 320 325
atc ctg tgt ggc ttc gct cgc gtt gag gtc cgt tct gtt ggc atc gtg 1123
Ile Leu Cys Gly Phe Ala Arg Val Glu Val Arg Ser Val Gly Ile Val
330 335 340
gct aac cag cca acc cag ttc gct ggc tgc ttg gat att aag gca tct 1171
Ala Asn Gln Pro Thr Gln Phe Ala Gly Cys Leu Asp Ile Lys Ala Ser
345 350 355
gag aag gct gcc cgt ttc atc cgc acc tgc gat gcc ttc aac atc cca 1219
Glu Lys Ala Ala Arg Phe Ile Arg Thr Cys Asp Ala Phe Asn Ile Pro
360 365 370
atc ctt gag ttc gtg gac gtt cca ggc ttc ctg cct ggc acc aac cag 1267
Ile Leu Glu Phe Val Asp Val Pro Gly Phe Leu Pro Gly Thr Asn Gln
375 380 385
gaa ttc gac ggc atc atc cgc cgc ggc gca aag ctg ctt tac gct tac 1315
Glu Phe Asp Gly Ile Ile Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr
390 395 400 405
gct gaa gca acc gtc ggc aag atc acc gtc atc acc cgc aag tcc tac 1363
Ala Glu Ala Thr Val Gly Lys Ile Thr Val Ile Thr Arg Lys Ser Tyr
410 415 420
ggc gga gcg tac tgc gtg atg ggt tcc aag gat atg ggc gct ggc ctg 1411
Gly Gly Ala Tyr Cys Val Met Gly Ser Lys Asp Met Gly Ala Gly Leu
425 430 435
gta 1414
Val
<210> 206
<211> 438
<212> PRT
<213> Corynebacterium glutamicum
<400> 206
Met Thr Ala Ala Gln Thr Lys Pro Asp Leu Thr Thr Thr Ala Gly Lys
1 5 10 15
Leu Ser Asp Leu Arg Ser Arg Leu Ala Glu Ala Gln Ala Pro Met Gly
20 25 30
Glu Ala Thr Val Glu Lys Val His Ala Ala Gly Arg Lys Thr Ala Arg
35 40 45
Glu Arg Ile Glu Tyr Leu Leu Asp Glu Gly Ser Phe Val Glu Ile Asp
50 55 60
Ala Leu Ala Arg His Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg
65 70 75 80
Pro Val Thr Asp Gly Val Val Thr Gly Tyr Gly Thr Ile Asp Gly Arg
85 90 95
Lys Val Cys Val Phe Ser Gln Asp Gly Ala Val Phe Gly Gly Ala Leu
100 105 110
Gly Glu Val Tyr Gly Glu Lys Ile Val Lys Val Met Asp Leu Ala Ile
115 120 125
Lys Thr Gly Val Pro Leu Ile Gly Ile Asn Glu Gly Ala Gly Ala Arg
130 135 140
Ile Gln Glu Gly Val Val Ser Leu Gly Leu Tyr Ser Gln Ile Phe Tyr
145 150 155 160
Arg Asn Thr Gln Ala Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met
165 170 175
Gly Ala Cys Ala Gly Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe
180 185 190
Ile Val Met Val Asp Gln Thr Ser Lys Met Phe Ile Thr Gly Pro Asp
195 200 205
Val Ile Lys Thr Val Thr Gly Glu Asp Val Thr Gln Glu Glu Leu Gly
210 215 220
Gly Ala His Thr His Met Ala Thr Ser Gly Thr Ser His Tyr Ser Ala
225 230 235 240
Ser Asp Asp Ser Asp Ala Leu Asp Trp Val Arg Glu Leu Thr Ser Tyr
245 250 255
Leu Pro Ser Asn Asn Arg Ala Glu Thr Pro Arg Gln Glu Ala Asp Ile
260 265 270
Met Ile Gly Ser Ile Gln Glu Asn Ile Asn Asp Val Asp Leu Glu Leu
275 280 285
Asp Thr Ile Ile Pro Asp Ser Pro Asn Gln Pro Tyr Asp Met Lys Glu
290 295 300
Val Ile Ser Arg Ile Val Asp Asp Ala Glu Phe Phe Glu Ile Gln Glu
305 310 315 320
Asp Tyr Ala Glu Asn Ile Leu Cys Gly Phe Ala Arg Val Glu Val Arg
325 330 335
Ser Val Gly Ile Val Ala Asn Gln Pro Thr Gln Phe Ala Gly Cys Leu
340 345 350
Asp Ile Lys Ala Ser Glu Lys Ala Ala Arg Phe Ile Arg Thr Cys Asp
355 360 365
Ala Phe Asn Ile Pro Ile Leu Glu Phe Val Asp Val Pro Gly Phe Leu
370 375 380
Pro Gly Thr Asn Gln Glu Phe Asp Gly Ile Ile Arg Arg Gly Ala Lys
385 390 395 400
Leu Leu Tyr Ala Tyr Ala Glu Ala Thr Val Gly Lys Ile Thr Val Ile
405 410 415
Thr Arg Lys Ser Tyr Gly Gly Ala Tyr Cys Val Met Gly Ser Lys Asp
420 425 430
Met Gly Ala Gly Leu Val
435
<210> 207
<211> 688
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(688)
<223> FRXA02320
<400> 207
gtatgttcac acaagaaccc tgcacaacgc cttcaaagta cgtcgaccac gaccaagcgc 60
attattcact ctcacccttc aggatttaga ctaagaaacc atg act gca gca cag 115
Met Thr Ala Ala Gln
1 5
acc aaa cct gac ctc acc acc acg gct gga aag ctg tcc gat ctt cgc 163
Thr Lys Pro Asp Leu Thr Thr Thr Ala Gly Lys Leu Ser Asp Leu Arg
10 15 20
tcc cgt ctt gca gaa gct caa gct cca atg ggc gaa gca act gta gaa 211
Ser Arg Leu Ala Glu Ala Gln Ala Pro Met Gly Glu Ala Thr Val Glu
25 30 35
aaa gtg cac gct gct ggc agg aag act gcc cgc gaa cgt atc gag tat 259
Lys Val His Ala Ala Gly Arg Lys Thr Ala Arg Glu Arg Ile Glu Tyr
40 45 50
ttg ctc gat gag ggc tct ttc gta gag atc gat gct ctt gct cgt cac 307
Leu Leu Asp Glu Gly Ser Phe Val Glu Ile Asp Ala Leu Ala Arg His
55 60 65
cgt tcc aag aac ttc ggc ctg gat gcc aag cgt cca gtt act gac ggt 355
Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg Pro Val Thr Asp Gly
70 75 80 85
gtt gtg act ggt tac ggc acc atc gat ggc cgt aag gtc tgt gtg ttc 403
Val Val Thr Gly Tyr Gly Thr Ile Asp Gly Arg Lys Val Cys Val Phe
90 95 100
tcc cag gac ggc gct gta ttc ggt ggc gct ttg ggt gaa gtt tat ggt 451
Ser Gln Asp Gly Ala Val Phe Gly Gly Ala Leu Gly Glu Val Tyr Gly
105 110 115
gaa aag atc gtt aag gtt atg gat ctt gcg atc aag acc ggt gtg cct 499
Glu Lys Ile Val Lys Val Met Asp Leu Ala Ile Lys Thr Gly Val Pro
120 125 130
ttg atc gga atc aat gag ggt gct ggt gcg cgt atc cag gaa ggt gtt 547
Leu Ile Gly Ile Asn Glu Gly Ala Gly Ala Arg Ile Gln Glu Gly Val
135 140 145
gtg tct ctg ggt ctg tac tca cag atc ttc tac cgc aac acc cag gcg 595
Val Ser Leu Gly Leu Tyr Ser Gln Ile Phe Tyr Arg Asn Thr Gln Ala
150 155 160 165
tct ggc gtt atc cca cag atc tct ttg atc atg ggt gcc tgc gct ggt 643
Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met Gly Ala Cys Ala Gly
170 175 180
ggt cac gtg tac tcc cct gct ctg act gac ttc atc gtc atg gtg 688
Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe Ile Val Met Val
185 190 195
<210> 208
<211> 196
<212> PRT
<213> Corynebacterium glutamicum
<400> 208
Met Thr Ala Ala Gln Thr Lys Pro Asp Leu Thr Thr Thr Ala Gly Lys
1 5 10 15
Leu Ser Asp Leu Arg Ser Arg Leu Ala Glu Ala Gln Ala Pro Met Gly
20 25 30
Glu Ala Thr Val Glu Lys Val His Ala Ala Gly Arg Lys Thr Ala Arg
35 40 45
Glu Arg Ile Glu Tyr Leu Leu Asp Glu Gly Ser Phe Val Glu Ile Asp
50 55 60
Ala Leu Ala Arg His Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg
65 70 75 80
Pro Val Thr Asp Gly Val Val Thr Gly Tyr Gly Thr Ile Asp Gly Arg
85 90 95
Lys Val Cys Val Phe Ser Gln Asp Gly Ala Val Phe Gly Gly Ala Leu
100 105 110
Gly Glu Val Tyr Gly Glu Lys Ile Val Lys Val Met Asp Leu Ala Ile
115 120 125
Lys Thr Gly Val Pro Leu Ile Gly Ile Asn Glu Gly Ala Gly Ala Arg
130 135 140
Ile Gln Glu Gly Val Val Ser Leu Gly Leu Tyr Ser Gln Ile Phe Tyr
145 150 155 160
Arg Asn Thr Gln Ala Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met
165 170 175
Gly Ala Cys Ala Gly Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe
180 185 190
Ile Val Met Val
195
<210> 209
<211> 519
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(519)
<223> FRXA02851
<220>
<221> misc_feature
<222> 135
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 209
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 215
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 258
<223> n indicates any nucleotide
<220>
<221> VARIANT
<222> 70
<223> Xaa =Val, Ala, Asp, or Gly
<220>
<221> VARIANT
<222> 72
<223> Xaa = Phe or Leu
<220>
<221> VARIANT
<222> 86
<223> Xaa = Cys, Trp, or stop codon
<400> 209
cct cgc cag aag gcc gac atc atg atc ggt tcc atc cag gaa aac atc 48
Pro Arg Gln Lys Ala Asp Ile Met Ile Gly Ser Ile Gln Glu Asn Ile
1 5 10 15
aac gat gtg gat ctg gaa ttg gac acc atc atc ccg gat tcc ccg aac 96
Asn Asp Val Asp Leu Glu Leu Asp Thr Ile Ile Pro Asp Ser Pro Asn
20 25 30
cag cct tat gac atg aag gaa gtt att tcc cgc atc gtn gac gac gcc 144
Gln Pro Tyr Asp Met Lys Glu Val Ile Ser Arg Ile Val Asp Asp Ala
35 40 45
gag ttc ttc gag atc cag gaa gac tac gca gag aac atc ctg tgt ggc 192
Glu Phe Phe Glu Ile Gln Glu Asp Tyr Ala Glu Asn Ile Leu Cys Gly
50 55 60
ttc gct cgc gtt gag gnc cgt tnt gtt ggc atc gtg gct aac cag cca 240
Phe Ala Arg Val Glu Xaa Arg Xaa Val Gly Ile Val Ala Asn Gln Pro
65 70 75 80
acc cag ttc gct ggc tgn ttg gat att aag gca tct gag aag gct gcc 288
Thr Gln Phe Ala Gly Xaa Leu Asp Ile Lys Ala Ser Glu Lys Ala Ala
85 90 95
cgt ttc atc cgc acc tgc gat gcc ttc aac atc cca atc ctt gag ttc 336
Arg Phe Ile Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Leu Glu Phe
100 105 110
gtg gac gtt cca ggc ttc ctg cct ggc acc aac cag gaa ttc gac ggc 384
Val Asp Val Pro Gly Phe Leu Pro Gly Thr Asn Gln Glu Phe Asp Gly
115 120 125
atc atc cgc cgc ggc gca aag ctg ctt tac gct tac gct gaa gca acc 432
Ile Ile Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr Ala Glu Ala Thr
130 135 140
gtc ggc aag atc acc gtc atc acc cgc aag tcc tac ggc gga gcg tac 480
Val Gly Lys Ile Thr Val Ile Thr Arg Lys Ser Tyr Gly Gly Ala Tyr
145 150 155 160
tgc gtg atg ggt tcc aag gat atg ggc gct ggc ctg gta 519
Cys Val Met Gly Ser Lys Asp Met Gly Ala Gly Leu Val
165 170
<210> 210
<211> 173
<212> PRT
<213> Corynebacterium glutamicum
<220>
<221> VARIANT
<222> 70
<223> Xaa =Val, Ala, Asp, or Gly
<220>
<221> VARIANT
<222> 72
<223> Xaa = Phe or Leu
<220>
<221> VARIANT
<222> 86
<223> Xaa = Cys, Trp, or stop codon
<400> 210
Pro Arg Gln Lys Ala Asp Ile Met Ile Gly Ser Ile Gln Glu Asn Ile
1 5 10 15
Asn Asp Val Asp Leu Glu Leu Asp Thr Ile Ile Pro Asp Ser Pro Asn
20 25 30
Gln Pro Tyr Asp Met Lys Glu Val Ile Ser Arg Ile Val Asp Asp Ala
35 40 45
Glu Phe Phe Glu Ile Gln Glu Asp Tyr Ala Glu Asn Ile Leu Cys Gly
50 55 60
Phe Ala Arg Val Glu Xaa Arg Xaa Val Gly Ile Val Ala Asn Gln Pro
65 70 75 80
Thr Gln Phe Ala Gly Xaa Leu Asp Ile Lys Ala Ser Glu Lys Ala Ala
85 90 95
Arg Phe Ile Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Leu Glu Phe
100 105 110
Val Asp Val Pro Gly Phe Leu Pro Gly Thr Asn Gln Glu Phe Asp Gly
115 120 125
Ile Ile Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr Ala Glu Ala Thr
130 135 140
Val Gly Lys Ile Thr Val Ile Thr Arg Lys Ser Tyr Gly Gly Ala Tyr
145 150 155 160
Cys Val Met Gly Ser Lys Asp Met Gly Ala Gly Leu Val
165 170
<210> 211
<211> 1752
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1729)
<223> RXN02321
<400> 211
tttaaaaact acccgcacgc agcacgaacc tgttcagtga tgtaaatcac cgcggaaata 60
ttgtggacgt tacccccgcc taccgctacg atttcaaaac atg acc att tcc tca 115
Met Thr Ile Ser Ser
1 5
cct ttg att gac gtc gcc aac ctt cca gac atc aac acc act gcc ggc 163
Pro Leu Ile Asp Val Ala Asn Leu Pro Asp Ile Asn Thr Thr Ala Gly
10 15 20
aag atc gcc gac ctt aag gct cgc cgc gcg gaa gcc cat ttc ccc atg 211
Lys Ile Ala Asp Leu Lys Ala Arg Arg Ala Glu Ala His Phe Pro Met
25 30 35
ggt gaa aag gca gta gag aag gtc cac gct gct gga cgc ctc act gcc 259
Gly Glu Lys Ala Val Glu Lys Val His Ala Ala Gly Arg Leu Thr Ala
40 45 50
cgt gag cgc ttg gat tac tta ctc gat gag ggc tcc ttc atc gag acc 307
Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly Ser Phe Ile Glu Thr
55 60 65
gat cag ctg gct cgc cac cgc acc acc gct ttc tgc ctg ggc gct aag 355
Asp Gln Leu Ala Arg His Arg Thr Thr Ala Phe Cys Leu Gly Ala Lys
70 75 80 85
cgt cct gca acc gac ggt atc gtg acc ggc tgg ggc acc att gat gga 403
Arg Pro Ala Thr Asp Gly Ile Val Thr Gly Trp Gly Thr Ile Asp Gly
90 95 100
cgc gaa gtc tgc atc ttc tcg cag gac ggc acc gta ttc ggt ggc gcg 451
Arg Glu Val Cys Ile Phe Ser Gln Asp Gly Thr Val Phe Gly Gly Ala
105 110 115
ctt ggt gag gtg tac ggc gaa aag atg atc aag atc atg gag ctg gca 499
Leu Gly Glu Val Tyr Gly Glu Lys Met Ile Lys Ile Met Glu Leu Ala
120 125 130
atc gac acc ggc cgc cca ttg atc ggt ctt tac gaa ggc gct ggc gct 547
Ile Asp Thr Gly Arg Pro Leu Ile Gly Leu Tyr Glu Gly Ala Gly Ala
135 140 145
cgt att cag gac ggc gct gtc tcc ctg gac ttc att tcc cag acc ttc 595
Arg Ile Gln Asp Gly Ala Val Ser Leu Asp Phe Ile Ser Gln Thr Phe
150 155 160 165
tac caa aac att cag gct tct ggc gtt atc cca cag atc tcc gtc atc 643
Tyr Gln Asn Ile Gln Ala Ser Gly Val Ile Pro Gln Ile Ser Val Ile
170 175 180
atg ggc gca tgt gca ggt ggc aac gct tac ggc cca gct ctg acc gac 691
Met Gly Ala Cys Ala Gly Gly Asn Ala Tyr Gly Pro Ala Leu Thr Asp
185 190 195
ttc gtg gtc atg gtg gac aag acc tcc aag atg ttc gtt acc ggc cca 739
Phe Val Val Met Val Asp Lys Thr Ser Lys Met Phe Val Thr Gly Pro
200 205 210
gac gtg atc aag acc gtc acc ggc gag gaa atc acc cag gaa gag ctt 787
Asp Val Ile Lys Thr Val Thr Gly Glu Glu Ile Thr Gln Glu Glu Leu
215 220 225
ggc gga gca acc acc cac atg gtg acc gct ggt aac tcc cac tac acc 835
Gly Gly Ala Thr Thr His Met Val Thr Ala Gly Asn Ser His Tyr Thr
230 235 240 245
gct gcg acc gat gag gaa gca ctg gat tgg gta cag gac ctg gtg tcc 883
Ala Ala Thr Asp Glu Glu Ala Leu Asp Trp Val Gln Asp Leu Val Ser
250 255 260
ttc ctc cca tcc aac aat cgc tcc tac gca ccg atg gaa gac ttc gac 931
Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro Met Glu Asp Phe Asp
265 270 275
gag gaa gaa ggc ggc gtt gaa gaa aac atc acc gct gac gat ctg aag 979
Glu Glu Glu Gly Gly Val Glu Glu Asn Ile Thr Ala Asp Asp Leu Lys
280 285 290
ctc gac gag atc atc cca gat tcc gcg acc gtt cct tac gac gtc cgc 1027
Leu Asp Glu Ile Ile Pro Asp Ser Ala Thr Val Pro Tyr Asp Val Arg
295 300 305
gat gtc atc gaa tgc ctc acc gac gat ggc gaa tac ctg gaa atc cag 1075
Asp Val Ile Glu Cys Leu Thr Asp Asp Gly Glu Tyr Leu Glu Ile Gln
310 315 320 325
gca gac cgc gca gaa aac gtt gtt att gca ttc ggc cgc atc gaa ggc 1123
Ala Asp Arg Ala Glu Asn Val Val Ile Ala Phe Gly Arg Ile Glu Gly
330 335 340
cag tcc gtt ggc ttt gtt gcc aac cag cca acc cag ttc gct ggc tgc 1171
Gln Ser Val Gly Phe Val Ala Asn Gln Pro Thr Gln Phe Ala Gly Cys
345 350 355
ctg gac atc gac tcc tct gag aag gca gct cgc ttc gtc cgc acc tgc 1219
Leu Asp Ile Asp Ser Ser Glu Lys Ala Ala Arg Phe Val Arg Thr Cys
360 365 370
gac gcg ttc aac atc cca atc gtc atg ctt gtc gac gtc ccc ggc ttc 1267
Asp Ala Phe Asn Ile Pro Ile Val Met Leu Val Asp Val Pro Gly Phe
375 380 385
ctc cca ggc gca ggc cag gag tac ggt ggc att ctg cgt cgt ggc gca 1315
Leu Pro Gly Ala Gly Gln Glu Tyr Gly Gly Ile Leu Arg Arg Gly Ala
390 395 400 405
aag ctg ctc tac gca tac ggc gaa gca acc gtt cca aag atc acc gtc 1363
Lys Leu Leu Tyr Ala Tyr Gly Glu Ala Thr Val Pro Lys Ile Thr Val
410 415 420
acc atg cgt aag gct tac ggc gga gcg tac tgc gtg atg ggt tcc aag 1411
Thr Met Arg Lys Ala Tyr Gly Gly Ala Tyr Cys Val Met Gly Ser Lys
425 430 435
ggc ttg ggc tct gac atc aac ctt gca tgg cca acc gca cag atc gcc 1459
Gly Leu Gly Ser Asp Ile Asn Leu Ala Trp Pro Thr Ala Gln Ile Ala
440 445 450
gtc atg ggc gct gct ggc gca gtt gga ttc atc tac cgc aag gag ctc 1507
Val Met Gly Ala Ala Gly Ala Val Gly Phe Ile Tyr Arg Lys Glu Leu
455 460 465
atg gca gct gat gcc aag ggc ctc gat acc gta gct ctg gct aag tcc 1555
Met Ala Ala Asp Ala Lys Gly Leu Asp Thr Val Ala Leu Ala Lys Ser
470 475 480 485
ttc gag cgc gag tat gaa gac cac atg ctc aac ccg tac cac gct gca 1603
Phe Glu Arg Glu Tyr Glu Asp His Met Leu Asn Pro Tyr His Ala Ala
490 495 500
gaa cgt ggc ctg atc gac gcc gtg atc ctg cca agc gaa acc cgc gga 1651
Glu Arg Gly Leu Ile Asp Ala Val Ile Leu Pro Ser Glu Thr Arg Gly
505 510 515
cag att tcc cgc aac ctt cgc ctg ctc aag cac aag aac gtc act cgc 1699
Gln Ile Ser Arg Asn Leu Arg Leu Leu Lys His Lys Asn Val Thr Arg
520 525 530
cct gct cgc aag cac ggc aac atg cca ctg taaatcggcg aatccataaa 1749
Pro Ala Arg Lys His Gly Asn Met Pro Leu
535 540
ggt 1752
<210> 212
<211> 543
<212> PRT
<213> Corynebacterium glutamicum
<400> 212
Met Thr Ile Ser Ser Pro Leu Ile Asp Val Ala Asn Leu Pro Asp Ile
1 5 10 15
Asn Thr Thr Ala Gly Lys Ile Ala Asp Leu Lys Ala Arg Arg Ala Glu
20 25 30
Ala His Phe Pro Met Gly Glu Lys Ala Val Glu Lys Val His Ala Ala
35 40 45
Gly Arg Leu Thr Ala Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly
50 55 60
Ser Phe Ile Glu Thr Asp Gln Leu Ala Arg His Arg Thr Thr Ala Phe
65 70 75 80
Cys Leu Gly Ala Lys Arg Pro Ala Thr Asp Gly Ile Val Thr Gly Trp
85 90 95
Gly Thr Ile Asp Gly Arg Glu Val Cys Ile Phe Ser Gln Asp Gly Thr
100 105 110
Val Phe Gly Gly Ala Leu Gly Glu Val Tyr Gly Glu Lys Met Ile Lys
115 120 125
Ile Met Glu Leu Ala Ile Asp Thr Gly Arg Pro Leu Ile Gly Leu Tyr
130 135 140
Glu Gly Ala Gly Ala Arg Ile Gln Asp Gly Ala Val Ser Leu Asp Phe
145 150 155 160
Ile Ser Gln Thr Phe Tyr Gln Asn Ile Gln Ala Ser Gly Val Ile Pro
165 170 175
Gln Ile Ser Val Ile Met Gly Ala Cys Ala Gly Gly Asn Ala Tyr Gly
180 185 190
Pro Ala Leu Thr Asp Phe Val Val Met Val Asp Lys Thr Ser Lys Met
195 200 205
Phe Val Thr Gly Pro Asp Val Ile Lys Thr Val Thr Gly Glu Glu Ile
210 215 220
Thr Gln Glu Glu Leu Gly Gly Ala Thr Thr His Met Val Thr Ala Gly
225 230 235 240
Asn Ser His Tyr Thr Ala Ala Thr Asp Glu Glu Ala Leu Asp Trp Val
245 250 255
Gln Asp Leu Val Ser Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro
260 265 270
Met Glu Asp Phe Asp Glu Glu Glu Gly Gly Val Glu Glu Asn Ile Thr
275 280 285
Ala Asp Asp Leu Lys Leu Asp Glu Ile Ile Pro Asp Ser Ala Thr Val
290 295 300
Pro Tyr Asp Val Arg Asp Val Ile Glu Cys Leu Thr Asp Asp Gly Glu
305 310 315 320
Tyr Leu Glu Ile Gln Ala Asp Arg Ala Glu Asn Val Val Ile Ala Phe
325 330 335
Gly Arg Ile Glu Gly Gln Ser Val Gly Phe Val Ala Asn Gln Pro Thr
340 345 350
Gln Phe Ala Gly Cys Leu Asp Ile Asp Ser Ser Glu Lys Ala Ala Arg
355 360 365
Phe Val Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Val Met Leu Val
370 375 380
Asp Val Pro Gly Phe Leu Pro Gly Ala Gly Gln Glu Tyr Gly Gly Ile
385 390 395 400
Leu Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr Gly Glu Ala Thr Val
405 410 415
Pro Lys Ile Thr Val Thr Met Arg Lys Ala Tyr Gly Gly Ala Tyr Cys
420 425 430
Val Met Gly Ser Lys Gly Leu Gly Ser Asp Ile Asn Leu Ala Trp Pro
435 440 445
Thr Ala Gln Ile Ala Val Met Gly Ala Ala Gly Ala Val Gly Phe Ile
450 455 460
Tyr Arg Lys Glu Leu Met Ala Ala Asp Ala Lys Gly Leu Asp Thr Val
465 470 475 480
Ala Leu Ala Lys Ser Phe Glu Arg Glu Tyr Glu Asp His Met Leu Asn
485 490 495
Pro Tyr His Ala Ala Glu Arg Gly Leu Ile Asp Ala Val Ile Leu Pro
500 505 510
Ser Glu Thr Arg Gly Gln Ile Ser Arg Asn Leu Arg Leu Leu Lys His
515 520 525
Lys Asn Val Thr Arg Pro Ala Arg Lys His Gly Asn Met Pro Leu
530 535 540
<210> 213
<211> 467
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(444)
<223> FRXA02321
<220>
<221> misc_feature
<222> 50
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 51
<223> n indicates any nucleotide
<220>
<221> VARIANT
<222> 17
<223> Xaa = Val, Ala, Asp, Glu, or Gly
<400> 213
gag tac ggt ggc att ctg cgt cgt ggc gca aag ctg ctc tac gca tcg 48
Glu Tyr Gly Gly Ile Leu Arg Arg Gly Ala Lys Leu Leu Tyr Ala Ser
1 5 10 15
gnn gaa gca ccg gtt cca aag atc acc gtc acc atg cgt aag gct tac 96
Xaa Glu Ala Pro Val Pro Lys Ile Thr Val Thr Met Arg Lys Ala Tyr
20 25 30
ggc gga gcg tac tgc gtg atg ggt tcc aag ggc ttg ggc tct gac atc 144
Gly Gly Ala Tyr Cys Val Met Gly Ser Lys Gly Leu Gly Ser Asp Ile
35 40 45
aac ctt gca tgg cca acc gca cag atc gcc gtc atg ggc gct gct ggc 192
Asn Leu Ala Trp Pro Thr Ala Gln Ile Ala Val Met Gly Ala Ala Gly
50 55 60
gca gtt gga ttc atc tac cgc aag gag ctc atg gca gct gat gcc aag 240
Ala Val Gly Phe Ile Tyr Arg Lys Glu Leu Met Ala Ala Asp Ala Lys
65 70 75 80
ggc ctc gat acc gta gct ctg gct aag tcc ttc gag cgc gag tat gaa 288
Gly Leu Asp Thr Val Ala Leu Ala Lys Ser Phe Glu Arg Glu Tyr Glu
85 90 95
gac cac atg ctc aac ccg tac cac gct gca gaa cgt ggc ctg atc gac 336
Asp His Met Leu Asn Pro Tyr His Ala Ala Glu Arg Gly Leu Ile Asp
100 105 110
gcc gtg atc ctg cca agc gaa acc cgc gga cag att tcc cgc aac ctt 384
Ala Val Ile Leu Pro Ser Glu Thr Arg Gly Gln Ile Ser Arg Asn Leu
115 120 125
cgc ctg ctc aag cac aag aac gtc act cgc cct gct cgc aag cac ggc 432
Arg Leu Leu Lys His Lys Asn Val Thr Arg Pro Ala Arg Lys His Gly
130 135 140
aac atg cca ctg taaatcggcg aatccataaa ggt 467
Asn Met Pro Leu
145
<210> 214
<211> 148
<212> PRT
<213> Corynebacterium glutamicum
<220>
<221> VARIANT
<222> 17
<223> Xaa = Val, Ala, Asp, Glu, or Gly
<400> 214
Glu Tyr Gly Gly Ile Leu Arg Arg Gly Ala Lys Leu Leu Tyr Ala Ser
1 5 10 15
Xaa Glu Ala Pro Val Pro Lys Ile Thr Val Thr Met Arg Lys Ala Tyr
20 25 30
Gly Gly Ala Tyr Cys Val Met Gly Ser Lys Gly Leu Gly Ser Asp Ile
35 40 45
Asn Leu Ala Trp Pro Thr Ala Gln Ile Ala Val Met Gly Ala Ala Gly
50 55 60
Ala Val Gly Phe Ile Tyr Arg Lys Glu Leu Met Ala Ala Asp Ala Lys
65 70 75 80
Gly Leu Asp Thr Val Ala Leu Ala Lys Ser Phe Glu Arg Glu Tyr Glu
85 90 95
Asp His Met Leu Asn Pro Tyr His Ala Ala Glu Arg Gly Leu Ile Asp
100 105 110
Ala Val Ile Leu Pro Ser Glu Thr Arg Gly Gln Ile Ser Arg Asn Leu
115 120 125
Arg Leu Leu Lys His Lys Asn Val Thr Arg Pro Ala Arg Lys His Gly
130 135 140
Asn Met Pro Leu
145
<210> 215
<211> 514
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(514)
<223> FRXA02343
<400> 215
tttaaaaact acccgcacgc agcacgaacc tgttcagtga tgtaaatcac cgcggaaata 60
ttgtggacgt tacccccgcc taccgctacg atttcaaaac atg acc att tcc tca 115
Met Thr Ile Ser Ser
1 5
cct ttg att gac gtc gcc aac ctt cca gac atc aac acc act gcc ggc 163
Pro Leu Ile Asp Val Ala Asn Leu Pro Asp Ile Asn Thr Thr Ala Gly
10 15 20
aag atc gcc gac ctt aag gct cgc cgc gcg gaa gcc cat ttc ccc atg 211
Lys Ile Ala Asp Leu Lys Ala Arg Arg Ala Glu Ala His Phe Pro Met
25 30 35
ggt gaa aag gca gta gag aag gtc cac gct gct gga cgc ctc act gcc 259
Gly Glu Lys Ala Val Glu Lys Val His Ala Ala Gly Arg Leu Thr Ala
40 45 50
cgt gag cgc ttg gat tac tta ctc gat gag ggc tcc ttc atc gag acc 307
Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly Ser Phe Ile Glu Thr
55 60 65
gat cag ctg gct cgc cac cgc acc acc gct ttc tgc ctg ggc gct aag 355
Asp Gln Leu Ala Arg His Arg Thr Thr Ala Phe Cys Leu Gly Ala Lys
70 75 80 85
cgt cct gca acc gac ggc atc gtg acc ggc tgg ggc acc att gat gga 403
Arg Pro Ala Thr Asp Gly Ile Val Thr Gly Trp Gly Thr Ile Asp Gly
90 95 100
cgc gaa gtc tgc atc ttc tcg cag gac ggc acc gta ttc ggt ggc gcg 451
Arg Glu Val Cys Ile Phe Ser Gln Asp Gly Thr Val Phe Gly Gly Ala
105 110 115
ctt ggt gag gtg tac ggc gaa aag atg atc aag atc atg gag ctg gca 499
Leu Gly Glu Val Tyr Gly Glu Lys Met Ile Lys Ile Met Glu Leu Ala
120 125 130
atc gac acc ggc cgc 514
Ile Asp Thr Gly Arg
135
<210> 216
<211> 138
<212> PRT
<213> Corynebacterium glutamicum
<400> 216
Met Thr Ile Ser Ser Pro Leu Ile Asp Val Ala Asn Leu Pro Asp Ile
1 5 10 15
Asn Thr Thr Ala Gly Lys Ile Ala Asp Leu Lys Ala Arg Arg Ala Glu
20 25 30
Ala His Phe Pro Met Gly Glu Lys Ala Val Glu Lys Val His Ala Ala
35 40 45
Gly Arg Leu Thr Ala Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly
50 55 60
Ser Phe Ile Glu Thr Asp Gln Leu Ala Arg His Arg Thr Thr Ala Phe
65 70 75 80
Cys Leu Gly Ala Lys Arg Pro Ala Thr Asp Gly Ile Val Thr Gly Trp
85 90 95
Gly Thr Ile Asp Gly Arg Glu Val Cys Ile Phe Ser Gln Asp Gly Thr
100 105 110
Val Phe Gly Gly Ala Leu Gly Glu Val Tyr Gly Glu Lys Met Ile Lys
115 120 125
Ile Met Glu Leu Ala Ile Asp Thr Gly Arg
130 135
<210> 217
<211> 492
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(492)
<223> FRXA02850
<220>
<221> misc_feature
<222> 258
<223> n indicates any nucleotide
<220>
<221> misc_feature
<222> 302
<223> n indicates any nucleotide
<220>
<221> VARIANT
<222> 86
<223> Xaa = Ile or Met
<220>
<221> VARIANT
<222> 101
<223> Xaa = Val, Ala, Asp, or Gly
<400> 217
gaa gag ctt ggc gga gca acc acc cac atg gtg acc gct ggt aac tcc 48
Glu Glu Leu Gly Gly Ala Thr Thr His Met Val Thr Ala Gly Asn Ser
1 5 10 15
cac tac acc gct gcg acc gat gag gaa gca ctg gat tgg gta cag gac 96
His Tyr Thr Ala Ala Thr Asp Glu Glu Ala Leu Asp Trp Val Gln Asp
20 25 30
ctg gtg tcc ttc ctc cca tcc aac aat cgc tcc tac gca ccg atg gaa 144
Leu Val Ser Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro Met Glu
35 40 45
gac ttc gac gag gaa gaa ggc ggc gtt gaa gaa aac atc acc gct gac 192
Asp Phe Asp Glu Glu Glu Gly Gly Val Glu Glu Asn Ile Thr Ala Asp
50 55 60
gat ctg aag ctc gac gag atc atc cca gat tcc gcg acc gtt cct tac 240
Asp Leu Lys Leu Asp Glu Ile Ile Pro Asp Ser Ala Thr Val Pro Tyr
65 70 75 80
gac gtc cgc gat gtc atn gaa tgc ctc acc gac gat ggc gaa tac ctg 288
Asp Val Arg Asp Val Xaa Glu Cys Leu Thr Asp Asp Gly Glu Tyr Leu
85 90 95
gaa atc cag gca gnc cgc gca gaa aac gtt gtt att gca ttc ggc cgc 336
Glu Ile Gln Ala Xaa Arg Ala Glu Asn Val Val Ile Ala Phe Gly Arg
100 105 110
atc gaa ggc cag tcc gtt ggc ttt gtt gcc aac cag cca acc cag ttc 384
Ile Glu Gly Gln Ser Val Gly Phe Val Ala Asn Gln Pro Thr Gln Phe
115 120 125
gct ggc tgc ctg gac atc gac tcc tct gag aag gca gct cgc ttc gtc 432
Ala Gly Cys Leu Asp Ile Asp Ser Ser Glu Lys Ala Ala Arg Phe Val
130 135 140
cgc acc tgc gac gcg ttc aac atc cca atc gtc atg ctt gtg gac gtc 480
Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Val Met Leu Val Asp Val
145 150 155 160
ccc ggc ttc ctc 492
Pro Gly Phe Leu
<210> 218
<211> 164
<212> PRT
<213> Corynebacterium glutamicum
<220>
<221> VARIANT
<222> 86
<223> Xaa = Ile or Met
<220>
<221> VARIANT
<222> 101
<223> Xaa = Val, Ala, Asp, or Gly
<400> 218
Glu Glu Leu Gly Gly Ala Thr Thr His Met Val Thr Ala Gly Asn Ser
1 5 10 15
His Tyr Thr Ala Ala Thr Asp Glu Glu Ala Leu Asp Trp Val Gln Asp
20 25 30
Leu Val Ser Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro Met Glu
35 40 45
Asp Phe Asp Glu Glu Glu Gly Gly Val Glu Glu Asn Ile Thr Ala Asp
50 55 60
Asp Leu Lys Leu Asp Glu Ile Ile Pro Asp Ser Ala Thr Val Pro Tyr
65 70 75 80
Asp Val Arg Asp Val Xaa Glu Cys Leu Thr Asp Asp Gly Glu Tyr Leu
85 90 95
Glu Ile Gln Ala Xaa Arg Ala Glu Asn Val Val Ile Ala Phe Gly Arg
100 105 110
Ile Glu Gly Gln Ser Val Gly Phe Val Ala Asn Gln Pro Thr Gln Phe
115 120 125
Ala Gly Cys Leu Asp Ile Asp Ser Ser Glu Lys Ala Ala Arg Phe Val
130 135 140
Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Val Met Leu Val Asp Val
145 150 155 160
Pro Gly Phe Leu
<210> 219
<211> 1671
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1648)
<223> RXA02583
<400> 219
cagttgtcga tgaaccagaa atcggcacag tcggagctca tttgagtcgc cgcattgatg 60
agatttctcg gaagaattag taacggagag ctgacggaag ttg agt aac acc act 115
Leu Ser Asn Thr Thr
1 5
act gca gag aag cta gcg gat ctg cgc gca cgc ctg gag att gcc aaa 163
Thr Ala Glu Lys Leu Ala Asp Leu Arg Ala Arg Leu Glu Ile Ala Lys
10 15 20
gac cca ggt agt gaa cgc gca cgt aaa aag cgc gac gag gaa ggc cga 211
Asp Pro Gly Ser Glu Arg Ala Arg Lys Lys Arg Asp Glu Glu Gly Arg
25 30 35
acc acc cct cgt cag cgt att gat gct ctg ctt gat gcc gga tcc ttt 259
Thr Thr Pro Arg Gln Arg Ile Asp Ala Leu Leu Asp Ala Gly Ser Phe
40 45 50
gtg gag atc ggc gca cta ggc cgt acc ccg gat gaa ccc gat gcg cct 307
Val Glu Ile Gly Ala Leu Gly Arg Thr Pro Asp Glu Pro Asp Ala Pro
55 60 65
tac tct gac ggt gtg gtg act ggt tat ggt cgc atc gat ggt cgc cca 355
Tyr Ser Asp Gly Val Val Thr Gly Tyr Gly Arg Ile Asp Gly Arg Pro
70 75 80 85
gtg gcc atc tac gcc cat gac aag acc gtt tac ggt ggt tcc gtg ggc 403
Val Ala Ile Tyr Ala His Asp Lys Thr Val Tyr Gly Gly Ser Val Gly
90 95 100
atg act ttc gga cgt aaa gtc agc gaa gtc atg gac atg gct atc cgc 451
Met Thr Phe Gly Arg Lys Val Ser Glu Val Met Asp Met Ala Ile Arg
105 110 115
att ggt tgc cca gtt atc ggt att cag gat tcc ggc gga gcc cgc att 499
Ile Gly Cys Pro Val Ile Gly Ile Gln Asp Ser Gly Gly Ala Arg Ile
120 125 130
cag gat gcg gtg acc tcc ttg gcg atg tac tca gag atc gcg cgt cgt 547
Gln Asp Ala Val Thr Ser Leu Ala Met Tyr Ser Glu Ile Ala Arg Arg
135 140 145
cag ctt ccg ctg tct ggc cgc agc cct cag att tcc atc atg ctg ggt 595
Gln Leu Pro Leu Ser Gly Arg Ser Pro Gln Ile Ser Ile Met Leu Gly
150 155 160 165
aaa tcg gca ggt ggc gca gtg tat gca cct gtg acc act gac ttt gtt 643
Lys Ser Ala Gly Gly Ala Val Tyr Ala Pro Val Thr Thr Asp Phe Val
170 175 180
atc ggc gtt gat ggt gaa aca gaa atg tat gtc acc ggc cca gcc gtg 691
Ile Gly Val Asp Gly Glu Thr Glu Met Tyr Val Thr Gly Pro Ala Val
185 190 195
atc aag gaa gtc acc ggc gag cag atc act tcc gca gac ctc ggt ggc 739
Ile Lys Glu Val Thr Gly Glu Gln Ile Thr Ser Ala Asp Leu Gly Gly
200 205 210
ggt gcg cag cag atg caa aac ggc aac att tcc tat ttg gcg tcc tct 787
Gly Ala Gln Gln Met Gln Asn Gly Asn Ile Ser Tyr Leu Ala Ser Ser
215 220 225
gaa gaa gag gcc ctg aat atg gtc aag gat ttg ctc gac ttc ctg cct 835
Glu Glu Glu Ala Leu Asn Met Val Lys Asp Leu Leu Asp Phe Leu Pro
230 235 240 245
ttg acc tgc aat gat cca gcc cct gtg ttt gca gca cca acg gat gaa 883
Leu Thr Cys Asn Asp Pro Ala Pro Val Phe Ala Ala Pro Thr Asp Glu
250 255 260
gag atc gcc tac gac gaa gct ctg aac tcg ttc atg cct gac gac act 931
Glu Ile Ala Tyr Asp Glu Ala Leu Asn Ser Phe Met Pro Asp Asp Thr
265 270 275
aac cag ggc tac gac atg cat gac ctg ctg gac aag ctt ttc gac gac 979
Asn Gln Gly Tyr Asp Met His Asp Leu Leu Asp Lys Leu Phe Asp Asp
280 285 290
gcc aac ctg ctg gaa atc caa gag gag tac gcc ccc aac ctg atc act 1027
Ala Asn Leu Leu Glu Ile Gln Glu Glu Tyr Ala Pro Asn Leu Ile Thr
295 300 305
acc ttc gcc cgc gtt gat ggc aag gca gtc ggt gtg gtg gcc aac caa 1075
Thr Phe Ala Arg Val Asp Gly Lys Ala Val Gly Val Val Ala Asn Gln
310 315 320 325
cca atg gat aag gca ggc tgc atc gac gct gac gcc gcc gac aag ggc 1123
Pro Met Asp Lys Ala Gly Cys Ile Asp Ala Asp Ala Ala Asp Lys Gly
330 335 340
gcc cgc ttc atc cgt atc tgc gac gcc tac aac atc ccg atc atc ttc 1171
Ala Arg Phe Ile Arg Ile Cys Asp Ala Tyr Asn Ile Pro Ile Ile Phe
345 350 355
gtc gtg gac acc cct ggc tac ctg cct ggc gtg gac caa gag aag gtc 1219
Val Val Asp Thr Pro Gly Tyr Leu Pro Gly Val Asp Gln Glu Lys Val
360 365 370
ggt ttg att cac cgt ggc gca aag cta gcc ttc gca gtg gtg gaa tcg 1267
Gly Leu Ile His Arg Gly Ala Lys Leu Ala Phe Ala Val Val Glu Ser
375 380 385
acc gtc cct aag att tcc ttg atc gtg cgc aag gcc tac ggc gga gca 1315
Thr Val Pro Lys Ile Ser Leu Ile Val Arg Lys Ala Tyr Gly Gly Ala
390 395 400 405
tat gcc gtg atg ggt tcc aag aac ctc acc ggt gac ctc aac ttc gca 1363
Tyr Ala Val Met Gly Ser Lys Asn Leu Thr Gly Asp Leu Asn Phe Ala
410 415 420
tgg cca acc gca cag atc gcc gtg atg ggc gca gcc gca gct gtc gtg 1411
Trp Pro Thr Ala Gln Ile Ala Val Met Gly Ala Ala Ala Ala Val Val
425 430 435
atg atc cag ggc aag cag ctc gaa gcc gcc cca cct gag cag cgt gaa 1459
Met Ile Gln Gly Lys Gln Leu Glu Ala Ala Pro Pro Glu Gln Arg Glu
440 445 450
tac atg aag aaa ctg ttc atg gac ttc tac gat gag aac atg acc agc 1507
Tyr Met Lys Lys Leu Phe Met Asp Phe Tyr Asp Glu Asn Met Thr Ser
455 460 465
cca tat gtg gcc gcc gag cgt ggt tac atc gac gcc atg atc gaa cct 1555
Pro Tyr Val Ala Ala Glu Arg Gly Tyr Ile Asp Ala Met Ile Glu Pro
470 475 480 485
gca gag acc cgt ttg gtg ctt cgc cga gca gtc cgc cag ctg gaa acc 1603
Ala Glu Thr Arg Leu Val Leu Arg Arg Ala Val Arg Gln Leu Glu Thr
490 495 500
aag gct gtg cga gac ctc gac aag aag cac acg atc atg ccg atg 1648
Lys Ala Val Arg Asp Leu Asp Lys Lys His Thr Ile Met Pro Met
505 510 515
taacgtccaa agaattatcc aga 1671
<210> 220
<211> 516
<212> PRT
<213> Corynebacterium glutamicum
<400> 220
Leu Ser Asn Thr Thr Thr Ala Glu Lys Leu Ala Asp Leu Arg Ala Arg
1 5 10 15
Leu Glu Ile Ala Lys Asp Pro Gly Ser Glu Arg Ala Arg Lys Lys Arg
20 25 30
Asp Glu Glu Gly Arg Thr Thr Pro Arg Gln Arg Ile Asp Ala Leu Leu
35 40 45
Asp Ala Gly Ser Phe Val Glu Ile Gly Ala Leu Gly Arg Thr Pro Asp
50 55 60
Glu Pro Asp Ala Pro Tyr Ser Asp Gly Val Val Thr Gly Tyr Gly Arg
65 70 75 80
Ile Asp Gly Arg Pro Val Ala Ile Tyr Ala His Asp Lys Thr Val Tyr
85 90 95
Gly Gly Ser Val Gly Met Thr Phe Gly Arg Lys Val Ser Glu Val Met
100 105 110
Asp Met Ala Ile Arg Ile Gly Cys Pro Val Ile Gly Ile Gln Asp Ser
115 120 125
Gly Gly Ala Arg Ile Gln Asp Ala Val Thr Ser Leu Ala Met Tyr Ser
130 135 140
Glu Ile Ala Arg Arg Gln Leu Pro Leu Ser Gly Arg Ser Pro Gln Ile
145 150 155 160
Ser Ile Met Leu Gly Lys Ser Ala Gly Gly Ala Val Tyr Ala Pro Val
165 170 175
Thr Thr Asp Phe Val Ile Gly Val Asp Gly Glu Thr Glu Met Tyr Val
180 185 190
Thr Gly Pro Ala Val Ile Lys Glu Val Thr Gly Glu Gln Ile Thr Ser
195 200 205
Ala Asp Leu Gly Gly Gly Ala Gln Gln Met Gln Asn Gly Asn Ile Ser
210 215 220
Tyr Leu Ala Ser Ser Glu Glu Glu Ala Leu Asn Met Val Lys Asp Leu
225 230 235 240
Leu Asp Phe Leu Pro Leu Thr Cys Asn Asp Pro Ala Pro Val Phe Ala
245 250 255
Ala Pro Thr Asp Glu Glu Ile Ala Tyr Asp Glu Ala Leu Asn Ser Phe
260 265 270
Met Pro Asp Asp Thr Asn Gln Gly Tyr Asp Met His Asp Leu Leu Asp
275 280 285
Lys Leu Phe Asp Asp Ala Asn Leu Leu Glu Ile Gln Glu Glu Tyr Ala
290 295 300
Pro Asn Leu Ile Thr Thr Phe Ala Arg Val Asp Gly Lys Ala Val Gly
305 310 315 320
Val Val Ala Asn Gln Pro Met Asp Lys Ala Gly Cys Ile Asp Ala Asp
325 330 335
Ala Ala Asp Lys Gly Ala Arg Phe Ile Arg Ile Cys Asp Ala Tyr Asn
340 345 350
Ile Pro Ile Ile Phe Val Val Asp Thr Pro Gly Tyr Leu Pro Gly Val
355 360 365
Asp Gln Glu Lys Val Gly Leu Ile His Arg Gly Ala Lys Leu Ala Phe
370 375 380
Ala Val Val Glu Ser Thr Val Pro Lys Ile Ser Leu Ile Val Arg Lys
385 390 395 400
Ala Tyr Gly Gly Ala Tyr Ala Val Met Gly Ser Lys Asn Leu Thr Gly
405 410 415
Asp Leu Asn Phe Ala Trp Pro Thr Ala Gln Ile Ala Val Met Gly Ala
420 425 430
Ala Ala Ala Val Val Met Ile Gln Gly Lys Gln Leu Glu Ala Ala Pro
435 440 445
Pro Glu Gln Arg Glu Tyr Met Lys Lys Leu Phe Met Asp Phe Tyr Asp
450 455 460
Glu Asn Met Thr Ser Pro Tyr Val Ala Ala Glu Arg Gly Tyr Ile Asp
465 470 475 480
Ala Met Ile Glu Pro Ala Glu Thr Arg Leu Val Leu Arg Arg Ala Val
485 490 495
Arg Gln Leu Glu Thr Lys Ala Val Arg Asp Leu Asp Lys Lys His Thr
500 505 510
Ile Met Pro Met
515
<210> 221
<211> 1635
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1612)
<223> RXA00870
<400> 221
caagacggcg atgtcgccgc cgctgttgat accgcagcgc gacttgttca cacagatatt 60
caacaattca cttcgcagag catttaagga atttacacac atg tct gaa cca caa 115
Met Ser Glu Pro Gln
1 5
acc atc tcg cac tgg att gac ggc gcg att tcc cca tcc act tcc ggc 163
Thr Ile Ser His Trp Ile Asp Gly Ala Ile Ser Pro Ser Thr Ser Gly
10 15 20
aag acc gct cct gtc tac aat cct gca act ggc cag gtc acc gcc aat 211
Lys Thr Ala Pro Val Tyr Asn Pro Ala Thr Gly Gln Val Thr Ala Asn
25 30 35
gtt gcg ctg gct agc cag gaa gag atc gat gcc acc atc gct tct gcc 259
Val Ala Leu Ala Ser Gln Glu Glu Ile Asp Ala Thr Ile Ala Ser Ala
40 45 50
acc aag gct gct aag acg tgg ggc aac ctg tct atc gct aag cgc caa 307
Thr Lys Ala Ala Lys Thr Trp Gly Asn Leu Ser Ile Ala Lys Arg Gln
55 60 65
gct gtg ctt ttc aac ttc cgt gag ctg ctg aat gct cgc aag ggt gag 355
Ala Val Leu Phe Asn Phe Arg Glu Leu Leu Asn Ala Arg Lys Gly Glu
70 75 80 85
ctg gcg gag atc atc act gca gag cac ggc aag gtc ttg tcc gat gcc 403
Leu Ala Glu Ile Ile Thr Ala Glu His Gly Lys Val Leu Ser Asp Ala
90 95 100
atg ggt gaa atc ctg cgc ggc cag gaa gtc gtg gag ctt gct acc ggt 451
Met Gly Glu Ile Leu Arg Gly Gln Glu Val Val Glu Leu Ala Thr Gly
105 110 115
ttc cca cac ctg ctt aaa ggt gcg ttc aac gag aac gtc tcc acc ggc 499
Phe Pro His Leu Leu Lys Gly Ala Phe Asn Glu Asn Val Ser Thr Gly
120 125 130
att gat gtg tat tcc ttg aag cag cca ctg ggt gtt gtc ggt atc atc 547
Ile Asp Val Tyr Ser Leu Lys Gln Pro Leu Gly Val Val Gly Ile Ile
135 140 145
agc ccg ttc aac ttc cct gcg atg gtg ccg atg tgg ttt ttc cca atc 595
Ser Pro Phe Asn Phe Pro Ala Met Val Pro Met Trp Phe Phe Pro Ile
150 155 160 165
gca atc gct gca ggc aac gca gtt att ttg aag cct tca gag aag gat 643
Ala Ile Ala Ala Gly Asn Ala Val Ile Leu Lys Pro Ser Glu Lys Asp
170 175 180
cct tcg gca gcg ctg tgg atg gct cag atc tgg aag gaa gct ggt ctt 691
Pro Ser Ala Ala Leu Trp Met Ala Gln Ile Trp Lys Glu Ala Gly Leu
185 190 195
cca gac ggc gta ttc aac gtg ctc cag ggc gac aag ctg gct gtt gat 739
Pro Asp Gly Val Phe Asn Val Leu Gln Gly Asp Lys Leu Ala Val Asp
200 205 210
ggt ttg ctg aac agc cct gat gtc tct gcg att tcc ttc gtg ggt tcc 787
Gly Leu Leu Asn Ser Pro Asp Val Ser Ala Ile Ser Phe Val Gly Ser
215 220 225
acc cca atc gca aag tac atc tac gag act tcc gcg aag aac ggc aag 835
Thr Pro Ile Ala Lys Tyr Ile Tyr Glu Thr Ser Ala Lys Asn Gly Lys
230 235 240 245
cgc gtc cag gcg ttg ggc ggc gcg aag aac cac atg ctg gtg ctg cca 883
Arg Val Gln Ala Leu Gly Gly Ala Lys Asn His Met Leu Val Leu Pro
250 255 260
gat gct gat ctg gat ctg gtt gcc gat cag gca atc aac gca ggt tac 931
Asp Ala Asp Leu Asp Leu Val Ala Asp Gln Ala Ile Asn Ala Gly Tyr
265 270 275
ggc gct gcc ggt gag cgt tgc atg gct gtt tct gtg gtc ttg gct att 979
Gly Ala Ala Gly Glu Arg Cys Met Ala Val Ser Val Val Leu Ala Ile
280 285 290
gaa tct gtt gcc gac gag ctc att gag aag atc aag gag cgc atc gac 1027
Glu Ser Val Ala Asp Glu Leu Ile Glu Lys Ile Lys Glu Arg Ile Asp
295 300 305
acc ctg cgc atc ggc aac ggt gcc ggc gac gag cag ggc gag ccg cac 1075
Thr Leu Arg Ile Gly Asn Gly Ala Gly Asp Glu Gln Gly Glu Pro His
310 315 320 325
ctg ggc cca cta atc acc gac gtc cac cgc gac aag gtc gct tct tat 1123
Leu Gly Pro Leu Ile Thr Asp Val His Arg Asp Lys Val Ala Ser Tyr
330 335 340
gtc gac atc gct gag gcc gac ggc gcc aag atc atc gtg gac ggg cgt 1171
Val Asp Ile Ala Glu Ala Asp Gly Ala Lys Ile Ile Val Asp Gly Arg
345 350 355
aac tgc gcc gta gac ggg cac gag gag ggc ttc ttc ttc ggc cct acg 1219
Asn Cys Ala Val Asp Gly His Glu Glu Gly Phe Phe Phe Gly Pro Thr
360 365 370
ctt atc gac gac atc cca ctc acg ttc cgc gcc tac acc gaa gaa atc 1267
Leu Ile Asp Asp Ile Pro Leu Thr Phe Arg Ala Tyr Thr Glu Glu Ile
375 380 385
ttc ggc ccg gtc ctc tct gtc gtt cgt gtc gca tcc ttc gac gag gca 1315
Phe Gly Pro Val Leu Ser Val Val Arg Val Ala Ser Phe Asp Glu Ala
390 395 400 405
att gag ctg atc aac tcc ggt gaa ttc ggc aac gga acc gca atc ttc 1363
Ile Glu Leu Ile Asn Ser Gly Glu Phe Gly Asn Gly Thr Ala Ile Phe
410 415 420
acc aac gat ggt gga gcg gca cgc cgc ttc cag cat gag atc gaa gtg 1411
Thr Asn Asp Gly Gly Ala Ala Arg Arg Phe Gln His Glu Ile Glu Val
425 430 435
ggc atg atc ggc atc aac gta cca atc cca gtg cct gtt gcg tac cac 1459
Gly Met Ile Gly Ile Asn Val Pro Ile Pro Val Pro Val Ala Tyr His
440 445 450
tcc ttc ggt ggt tgg aag aac tcc ctc ttc ggt gac gcc aag gca tat 1507
Ser Phe Gly Gly Trp Lys Asn Ser Leu Phe Gly Asp Ala Lys Ala Tyr
455 460 465
ggc act caa ggt ttt gat ttc ttc acc agg gaa aag gcg atc acc agc 1555
Gly Thr Gln Gly Phe Asp Phe Phe Thr Arg Glu Lys Ala Ile Thr Ser
470 475 480 485
cgt tgg ctc gac cca gca acc cac ggt ggc att aac ctc ggt ttc cca 1603
Arg Trp Leu Asp Pro Ala Thr His Gly Gly Ile Asn Leu Gly Phe Pro
490 495 500
cag aac gat taattgaagg agagcacagg act 1635
Gln Asn Asp
<210> 222
<211> 504
<212> PRT
<213> Corynebacterium glutamicum
<400> 222
Met Ser Glu Pro Gln Thr Ile Ser His Trp Ile Asp Gly Ala Ile Ser
1 5 10 15
Pro Ser Thr Ser Gly Lys Thr Ala Pro Val Tyr Asn Pro Ala Thr Gly
20 25 30
Gln Val Thr Ala Asn Val Ala Leu Ala Ser Gln Glu Glu Ile Asp Ala
35 40 45
Thr Ile Ala Ser Ala Thr Lys Ala Ala Lys Thr Trp Gly Asn Leu Ser
50 55 60
Ile Ala Lys Arg Gln Ala Val Leu Phe Asn Phe Arg Glu Leu Leu Asn
65 70 75 80
Ala Arg Lys Gly Glu Leu Ala Glu Ile Ile Thr Ala Glu His Gly Lys
85 90 95
Val Leu Ser Asp Ala Met Gly Glu Ile Leu Arg Gly Gln Glu Val Val
100 105 110
Glu Leu Ala Thr Gly Phe Pro His Leu Leu Lys Gly Ala Phe Asn Glu
115 120 125
Asn Val Ser Thr Gly Ile Asp Val Tyr Ser Leu Lys Gln Pro Leu Gly
130 135 140
Val Val Gly Ile Ile Ser Pro Phe Asn Phe Pro Ala Met Val Pro Met
145 150 155 160
Trp Phe Phe Pro Ile Ala Ile Ala Ala Gly Asn Ala Val Ile Leu Lys
165 170 175
Pro Ser Glu Lys Asp Pro Ser Ala Ala Leu Trp Met Ala Gln Ile Trp
180 185 190
Lys Glu Ala Gly Leu Pro Asp Gly Val Phe Asn Val Leu Gln Gly Asp
195 200 205
Lys Leu Ala Val Asp Gly Leu Leu Asn Ser Pro Asp Val Ser Ala Ile
210 215 220
Ser Phe Val Gly Ser Thr Pro Ile Ala Lys Tyr Ile Tyr Glu Thr Ser
225 230 235 240
Ala Lys Asn Gly Lys Arg Val Gln Ala Leu Gly Gly Ala Lys Asn His
245 250 255
Met Leu Val Leu Pro Asp Ala Asp Leu Asp Leu Val Ala Asp Gln Ala
260 265 270
Ile Asn Ala Gly Tyr Gly Ala Ala Gly Glu Arg Cys Met Ala Val Ser
275 280 285
Val Val Leu Ala Ile Glu Ser Val Ala Asp Glu Leu Ile Glu Lys Ile
290 295 300
Lys Glu Arg Ile Asp Thr Leu Arg Ile Gly Asn Gly Ala Gly Asp Glu
305 310 315 320
Gln Gly Glu Pro His Leu Gly Pro Leu Ile Thr Asp Val His Arg Asp
325 330 335
Lys Val Ala Ser Tyr Val Asp Ile Ala Glu Ala Asp Gly Ala Lys Ile
340 345 350
Ile Val Asp Gly Arg Asn Cys Ala Val Asp Gly His Glu Glu Gly Phe
355 360 365
Phe Phe Gly Pro Thr Leu Ile Asp Asp Ile Pro Leu Thr Phe Arg Ala
370 375 380
Tyr Thr Glu Glu Ile Phe Gly Pro Val Leu Ser Val Val Arg Val Ala
385 390 395 400
Ser Phe Asp Glu Ala Ile Glu Leu Ile Asn Ser Gly Glu Phe Gly Asn
405 410 415
Gly Thr Ala Ile Phe Thr Asn Asp Gly Gly Ala Ala Arg Arg Phe Gln
420 425 430
His Glu Ile Glu Val Gly Met Ile Gly Ile Asn Val Pro Ile Pro Val
435 440 445
Pro Val Ala Tyr His Ser Phe Gly Gly Trp Lys Asn Ser Leu Phe Gly
450 455 460
Asp Ala Lys Ala Tyr Gly Thr Gln Gly Phe Asp Phe Phe Thr Arg Glu
465 470 475 480
Lys Ala Ile Thr Ser Arg Trp Leu Asp Pro Ala Thr His Gly Gly Ile
485 490 495
Asn Leu Gly Phe Pro Gln Asn Asp
500
<210> 223
<211> 1305
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1282)
<223> RXA01260
<400> 223
ctaaacgtgg gctgcattcc ttccaaagtc tctgatcaaa aacgctgaag ttgcccatac 60
ctttacccat gagaagaaga ccttcggcat caatggcgaa gtg acc ttc aac tat 115
Val Thr Phe Asn Tyr
1 5
gag gat gct cac aag cgt tcc cgt ggc gtt tcc gac aag atc gtt gga 163
Glu Asp Ala His Lys Arg Ser Arg Gly Val Ser Asp Lys Ile Val Gly
10 15 20
ggc gtt cat tac ttg atg aag aag aac aag atc atc gaa att cat ggt 211
Gly Val His Tyr Leu Met Lys Lys Asn Lys Ile Ile Glu Ile His Gly
25 30 35
ctt gga aac ttc aag gat gct aag act ctt gag gtc acc gac ggt aag 259
Leu Gly Asn Phe Lys Asp Ala Lys Thr Leu Glu Val Thr Asp Gly Lys
40 45 50
gat gct ggc aag acc atc acc ttt gat gac tgc atc atc gca acc ggt 307
Asp Ala Gly Lys Thr Ile Thr Phe Asp Asp Cys Ile Ile Ala Thr Gly
55 60 65
tcg gta gtc aac acc ctc cgt ggc gtt gac ttc tca gag aac gtt gtg 355
Ser Val Val Asn Thr Leu Arg Gly Val Asp Phe Ser Glu Asn Val Val
70 75 80 85
tct ttt gaa gag cag att ctt aac cct gtt gcg cca aag aag atg gtc 403
Ser Phe Glu Glu Gln Ile Leu Asn Pro Val Ala Pro Lys Lys Met Val
90 95 100
att gtt ggt gca ggc gca att gga atg gaa ttc gcc tac gtt ctt ggt 451
Ile Val Gly Ala Gly Ala Ile Gly Met Glu Phe Ala Tyr Val Leu Gly
105 110 115
aac tac ggt gta gat gta acc gtc atc gag ttc atg gat cgt gtg ctt 499
Asn Tyr Gly Val Asp Val Thr Val Ile Glu Phe Met Asp Arg Val Leu
120 125 130
cca aat gaa gat gct gaa gtc tcc aag gtt att gca aag gcc tac aag 547
Pro Asn Glu Asp Ala Glu Val Ser Lys Val Ile Ala Lys Ala Tyr Lys
135 140 145
aag atg ggc gtt aag ctt ctt cct ggc cat gca acc act gct gtt cgg 595
Lys Met Gly Val Lys Leu Leu Pro Gly His Ala Thr Thr Ala Val Arg
150 155 160 165
gac aac ggt gac ttt gtc gag gtt gat tac cag aag aag ggc tct gac 643
Asp Asn Gly Asp Phe Val Glu Val Asp Tyr Gln Lys Lys Gly Ser Asp
170 175 180
aag aca gag act ctt act gtt gat cga gtc atg gtt tcc gtt ggt ttc 691
Lys Thr Glu Thr Leu Thr Val Asp Arg Val Met Val Ser Val Gly Phe
185 190 195
cgt cca cgc gtt gag gga ttt ggt ctt gaa aac act ggc gtt aag ctc 739
Arg Pro Arg Val Glu Gly Phe Gly Leu Glu Asn Thr Gly Val Lys Leu
200 205 210
acc gag cgt ggc gca atc gag atc gat gat tac atg cgt acc aac gtc 787
Thr Glu Arg Gly Ala Ile Glu Ile Asp Asp Tyr Met Arg Thr Asn Val
215 220 225
gat ggc att tac gcc atc ggt gac gtg acc gcc aag ctt cag ctt gct 835
Asp Gly Ile Tyr Ala Ile Gly Asp Val Thr Ala Lys Leu Gln Leu Ala
230 235 240 245
cac gtc gca gaa gca cag ggc att gtt gcc gca gag act att gct ggt 883
His Val Ala Glu Ala Gln Gly Ile Val Ala Ala Glu Thr Ile Ala Gly
250 255 260
gca gaa act cag act ctt ggt gat tac atg atg atg cca cgt gca acc 931
Ala Glu Thr Gln Thr Leu Gly Asp Tyr Met Met Met Pro Arg Ala Thr
265 270 275
ttc tgc aac cca cag gtt tct tcc ttt ggt tac acc gaa gag cag gcc 979
Phe Cys Asn Pro Gln Val Ser Ser Phe Gly Tyr Thr Glu Glu Gln Ala
280 285 290
aag gag aag tgg cca gat cgt gag atc aag gtt gct tcc ttc cca ttc 1027
Lys Glu Lys Trp Pro Asp Arg Glu Ile Lys Val Ala Ser Phe Pro Phe
295 300 305
tct gca aac ggt aaa gca gtt ggc ctg gca gaa act gat ggt ttc gca 1075
Ser Ala Asn Gly Lys Ala Val Gly Leu Ala Glu Thr Asp Gly Phe Ala
310 315 320 325
aag atc gtt gct gat gca gaa ttc ggt gag ctg ctc ggt gca cac ctg 1123
Lys Ile Val Ala Asp Ala Glu Phe Gly Glu Leu Leu Gly Ala His Leu
330 335 340
gtt gga gca aat gca tca gag ctc atc aat gaa ttg gtg ctt gct cag 1171
Val Gly Ala Asn Ala Ser Glu Leu Ile Asn Glu Leu Val Leu Ala Gln
345 350 355
aac tgg gat ctc acc act gaa gag atc tct cgt agc gtc cat att cac 1219
Asn Trp Asp Leu Thr Thr Glu Glu Ile Ser Arg Ser Val His Ile His
360 365 370
cca acg cta tct gag gca gtt aag gaa gct gca cac ggt atc tct gga 1267
Pro Thr Leu Ser Glu Ala Val Lys Glu Ala Ala His Gly Ile Ser Gly
375 380 385
cac atg atc aac ttc tagaatccac ctcgttggcc ctg 1305
His Met Ile Asn Phe
390
<210> 224
<211> 394
<212> PRT
<213> Corynebacterium glutamicum
<400> 224
Val Thr Phe Asn Tyr Glu Asp Ala His Lys Arg Ser Arg Gly Val Ser
1 5 10 15
Asp Lys Ile Val Gly Gly Val His Tyr Leu Met Lys Lys Asn Lys Ile
20 25 30
Ile Glu Ile His Gly Leu Gly Asn Phe Lys Asp Ala Lys Thr Leu Glu
35 40 45
Val Thr Asp Gly Lys Asp Ala Gly Lys Thr Ile Thr Phe Asp Asp Cys
50 55 60
Ile Ile Ala Thr Gly Ser Val Val Asn Thr Leu Arg Gly Val Asp Phe
65 70 75 80
Ser Glu Asn Val Val Ser Phe Glu Glu Gln Ile Leu Asn Pro Val Ala
85 90 95
Pro Lys Lys Met Val Ile Val Gly Ala Gly Ala Ile Gly Met Glu Phe
100 105 110
Ala Tyr Val Leu Gly Asn Tyr Gly Val Asp Val Thr Val Ile Glu Phe
115 120 125
Met Asp Arg Val Leu Pro Asn Glu Asp Ala Glu Val Ser Lys Val Ile
130 135 140
Ala Lys Ala Tyr Lys Lys Met Gly Val Lys Leu Leu Pro Gly His Ala
145 150 155 160
Thr Thr Ala Val Arg Asp Asn Gly Asp Phe Val Glu Val Asp Tyr Gln
165 170 175
Lys Lys Gly Ser Asp Lys Thr Glu Thr Leu Thr Val Asp Arg Val Met
180 185 190
Val Ser Val Gly Phe Arg Pro Arg Val Glu Gly Phe Gly Leu Glu Asn
195 200 205
Thr Gly Val Lys Leu Thr Glu Arg Gly Ala Ile Glu Ile Asp Asp Tyr
210 215 220
Met Arg Thr Asn Val Asp Gly Ile Tyr Ala Ile Gly Asp Val Thr Ala
225 230 235 240
Lys Leu Gln Leu Ala His Val Ala Glu Ala Gln Gly Ile Val Ala Ala
245 250 255
Glu Thr Ile Ala Gly Ala Glu Thr Gln Thr Leu Gly Asp Tyr Met Met
260 265 270
Met Pro Arg Ala Thr Phe Cys Asn Pro Gln Val Ser Ser Phe Gly Tyr
275 280 285
Thr Glu Glu Gln Ala Lys Glu Lys Trp Pro Asp Arg Glu Ile Lys Val
290 295 300
Ala Ser Phe Pro Phe Ser Ala Asn Gly Lys Ala Val Gly Leu Ala Glu
305 310 315 320
Thr Asp Gly Phe Ala Lys Ile Val Ala Asp Ala Glu Phe Gly Glu Leu
325 330 335
Leu Gly Ala His Leu Val Gly Ala Asn Ala Ser Glu Leu Ile Asn Glu
340 345 350
Leu Val Leu Ala Gln Asn Trp Asp Leu Thr Thr Glu Glu Ile Ser Arg
355 360 365
Ser Val His Ile His Pro Thr Leu Ser Glu Ala Val Lys Glu Ala Ala
370 375 380
His Gly Ile Ser Gly His Met Ile Asn Phe
385 390
<210> 225
<211> 294
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(271)
<223> RXA01261
<400> 225
gtgggtgttt ttcattttct tccactctaa aattaagtat ggaaaaccaa ccgcacccgg 60
atgcacgaca atgacccact aaacacgtat ccttgaatgc gtg act gaa cat tat 115
Val Thr Glu His Tyr
1 5
gac gta gta gta ctc gga gcc ggc ccc ggt ggc tat gtc tcc gcc atc 163
Asp Val Val Val Leu Gly Ala Gly Pro Gly Gly Tyr Val Ser Ala Ile
10 15 20
cgt gca gcg cag ctt ggc aag aag gtt gct gta att gag aag cag tac 211
Arg Ala Ala Gln Leu Gly Lys Lys Val Ala Val Ile Glu Lys Gln Tyr
25 30 35
tgg ggt ggt gtt tgc cta aac gtg ggc tgc att cct tcc aaa gtc tct 259
Trp Gly Gly Val Cys Leu Asn Val Gly Cys Ile Pro Ser Lys Val Ser
40 45 50
gat caa aaa cgc tgaagttgcc cataccttta ccc 294
Asp Gln Lys Arg
55
<210> 226
<211> 57
<212> PRT
<213> Corynebacterium glutamicum
<400> 226
Val Thr Glu His Tyr Asp Val Val Val Leu Gly Ala Gly Pro Gly Gly
1 5 10 15
Tyr Val Ser Ala Ile Arg Ala Ala Gln Leu Gly Lys Lys Val Ala Val
20 25 30
Ile Glu Lys Gln Tyr Trp Gly Gly Val Cys Leu Asn Val Gly Cys Ile
35 40 45
Pro Ser Lys Val Ser Asp Gln Lys Arg
50 55
<210> 227
<211> 555
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(532)
<223> RXA01136
<400> 227
ccctcgcaac accgacggta gcctcttgga aatggcgcgc atcgtgcgtg agctttcccg 60
ctaggacctg tctactgcct tcactttgtg cgaacaccgc atg acc ttg gat tac 115
Met Thr Leu Asp Tyr
1 5
ttc aag gca tcc ggc act gac tat gct ttg gga ttg gct gca gag tcg 163
Phe Lys Ala Ser Gly Thr Asp Tyr Ala Leu Gly Leu Ala Ala Glu Ser
10 15 20
gaa ggg gca cga cgc act ggt atc acc ggc atg gcg agt gca ttc aag 211
Glu Gly Ala Arg Arg Thr Gly Ile Thr Gly Met Ala Ser Ala Phe Lys
25 30 35
gag ttt gct ggt tgt ggt gag atc gac ctt gaa gca acc agg gta gaa 259
Glu Phe Ala Gly Cys Gly Glu Ile Asp Leu Glu Ala Thr Arg Val Glu
40 45 50
ggt ggc ctc aaa gtt agt gga aag ctt cgt tgg gct tcc aac ttg tgc 307
Gly Gly Leu Lys Val Ser Gly Lys Leu Arg Trp Ala Ser Asn Leu Cys
55 60 65
gaa gat cca gtg att gtg cct gct gca aag acc gca gag ggc tta caa 355
Glu Asp Pro Val Ile Val Pro Ala Ala Lys Thr Ala Glu Gly Leu Gln
70 75 80 85
cta ctg ttc gca ttg ggc gca gaa acc gaa ggt gtc acc ctc ggt tct 403
Leu Leu Phe Ala Leu Gly Ala Glu Thr Glu Gly Val Thr Leu Gly Ser
90 95 100
tca ctt gct cta ctc ggt ttg aac gca act gct tgc gct tgg gtg agc 451
Ser Leu Ala Leu Leu Gly Leu Asn Ala Thr Ala Cys Ala Trp Val Ser
105 110 115
ttt gag gat gtc ttc att cct ggg gct cag att cta agc cac gat ttc 499
Phe Glu Asp Val Phe Ile Pro Gly Ala Gln Ile Leu Ser His Asp Phe
120 125 130
ctt acc ttg tgg cat cgg tgc gcc caa cct tcg tgatcctacg gatctccgaa 552
Leu Thr Leu Trp His Arg Cys Ala Gln Pro Ser
135 140
tac 555
<210> 228
<211> 144
<212> PRT
<213> Corynebacterium glutamicum
<400> 228
Met Thr Leu Asp Tyr Phe Lys Ala Ser Gly Thr Asp Tyr Ala Leu Gly
1 5 10 15
Leu Ala Ala Glu Ser Glu Gly Ala Arg Arg Thr Gly Ile Thr Gly Met
20 25 30
Ala Ser Ala Phe Lys Glu Phe Ala Gly Cys Gly Glu Ile Asp Leu Glu
35 40 45
Ala Thr Arg Val Glu Gly Gly Leu Lys Val Ser Gly Lys Leu Arg Trp
50 55 60
Ala Ser Asn Leu Cys Glu Asp Pro Val Ile Val Pro Ala Ala Lys Thr
65 70 75 80
Ala Glu Gly Leu Gln Leu Leu Phe Ala Leu Gly Ala Glu Thr Glu Gly
85 90 95
Val Thr Leu Gly Ser Ser Leu Ala Leu Leu Gly Leu Asn Ala Thr Ala
100 105 110
Cys Ala Trp Val Ser Phe Glu Asp Val Phe Ile Pro Gly Ala Gln Ile
115 120 125
Leu Ser His Asp Phe Leu Thr Leu Trp His Arg Cys Ala Gln Pro Ser
130 135 140
<210> 229
<211> 1140
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1117)
<223> RXN00559
<400> 229
cccttcaatc cagtctttga cggccaatac ggcttgccgg gtttccagcg gatcaatcct 60
catgaagcat cagcctagta cgaaccgtta aagtgtccat atg tct gat aat ccg 115
Met Ser Asp Asn Pro
1 5
cat gag aat ccc cgt gag aat cca cac cgc tcc cca gaa gtc gtc ctt 163
His Glu Asn Pro Arg Glu Asn Pro His Arg Ser Pro Glu Val Val Leu
10 15 20
cgt ttc atg gct gcc cct act gac gtt ttg atg gct ggt agc cat ggc 211
Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met Ala Gly Ser His Gly
25 30 35
gtt ggc ggt ggc cga gtc ctg gaa tgg atc gat aag gct gct tat gct 259
Val Gly Gly Gly Arg Val Leu Glu Trp Ile Asp Lys Ala Ala Tyr Ala
40 45 50
tgt gct acc cag tgg tct gga acc tac tgt gtc act gct tat gtt ggt 307
Cys Ala Thr Gln Trp Ser Gly Thr Tyr Cys Val Thr Ala Tyr Val Gly
55 60 65
cac att cac ttc act cgc cct att ccc tct ggc cac atg gtc gag gtg 355
His Ile His Phe Thr Arg Pro Ile Pro Ser Gly His Met Val Glu Val
70 75 80 85
cgt tcc cgc att gcg atg act ggc cgt tcc tcc atg cac atc gtg aat 403
Arg Ser Arg Ile Ala Met Thr Gly Arg Ser Ser Met His Ile Val Asn
90 95 100
gag gtg ctt tct gcg gat cct cgc gat ggc aac tac acc cgt gcg tgt 451
Glu Val Leu Ser Ala Asp Pro Arg Asp Gly Asn Tyr Thr Arg Ala Cys
105 110 115
gac tgc ttg gtt att ttc gtg gcg aag gac acc gca act ggt cgc gct 499
Asp Cys Leu Val Ile Phe Val Ala Lys Asp Thr Ala Thr Gly Arg Ala
120 125 130
acc cca gtt cct tca ttt acc cct aag aat gaa gaa gag cag cgc gtg 547
Thr Pro Val Pro Ser Phe Thr Pro Lys Asn Glu Glu Glu Gln Arg Val
135 140 145
ttg gaa gct gct aac tcc cgc atc ggg ctg cgc aag gct att gaa gcg 595
Leu Glu Ala Ala Asn Ser Arg Ile Gly Leu Arg Lys Ala Ile Glu Ala
150 155 160 165
gag atg gaa aag cag acg tac aac gga cct tct gag gcc cct cgt ttg 643
Glu Met Glu Lys Gln Thr Tyr Asn Gly Pro Ser Glu Ala Pro Arg Leu
170 175 180
att acc cgc ttc ttg gct aag cca aca gat atc aac tgg ggt ggc aag 691
Ile Thr Arg Phe Leu Ala Lys Pro Thr Asp Ile Asn Trp Gly Gly Lys
185 190 195
gtc cac ggt ggc act gcc atg gaa tgg atc gat gag gcg ggt gct gcg 739
Val His Gly Gly Thr Ala Met Glu Trp Ile Asp Glu Ala Gly Ala Ala
200 205 210
tgc acc atg gag tgg tct ggt aac cac acc gtt gcg gtt tat gct ggt 787
Cys Thr Met Glu Trp Ser Gly Asn His Thr Val Ala Val Tyr Ala Gly
215 220 225
ggt atc cgc ttc tac cag ccc att cag atc ggt gac ctc att gag gtg 835
Gly Ile Arg Phe Tyr Gln Pro Ile Gln Ile Gly Asp Leu Ile Glu Val
230 235 240 245
gac gcc cgc atg atg cgt acc gat aag cgt tcc atg cag atg tcc atc 883
Asp Ala Arg Met Met Arg Thr Asp Lys Arg Ser Met Gln Met Ser Ile
250 255 260
cac gtc cgt gcc ggt gat gct cac cgt ggc cgt gct gag cta gaa acc 931
His Val Arg Ala Gly Asp Ala His Arg Gly Arg Ala Glu Leu Glu Thr
265 270 275
gct att cac gca acg gtg acc tac tta gga att gat gtc gac gga gag 979
Ala Ile His Ala Thr Val Thr Tyr Leu Gly Ile Asp Val Asp Gly Glu
280 285 290
cct ttg cct gca cca cag ttt gtg cct cgt acc cct gag gat atc cag 1027
Pro Leu Pro Ala Pro Gln Phe Val Pro Arg Thr Pro Glu Asp Ile Gln
295 300 305
ttg gct gag cat gca aac atc ctg agg gat ctg cgt gct gat tac acc 1075
Leu Ala Glu His Ala Asn Ile Leu Arg Asp Leu Arg Ala Asp Tyr Thr
310 315 320 325
cca atg ccg ctg ttc cag cgc agg gtt cca ctg cag atc gac 1117
Pro Met Pro Leu Phe Gln Arg Arg Val Pro Leu Gln Ile Asp
330 335
tagttagacc cgaaaaagcc ccc 1140
<210> 230
<211> 339
<212> PRT
<213> Corynebacterium glutamicum
<400> 230
Met Ser Asp Asn Pro His Glu Asn Pro Arg Glu Asn Pro His Arg Ser
1 5 10 15
Pro Glu Val Val Leu Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met
20 25 30
Ala Gly Ser His Gly Val Gly Gly Gly Arg Val Leu Glu Trp Ile Asp
35 40 45
Lys Ala Ala Tyr Ala Cys Ala Thr Gln Trp Ser Gly Thr Tyr Cys Val
50 55 60
Thr Ala Tyr Val Gly His Ile His Phe Thr Arg Pro Ile Pro Ser Gly
65 70 75 80
His Met Val Glu Val Arg Ser Arg Ile Ala Met Thr Gly Arg Ser Ser
85 90 95
Met His Ile Val Asn Glu Val Leu Ser Ala Asp Pro Arg Asp Gly Asn
100 105 110
Tyr Thr Arg Ala Cys Asp Cys Leu Val Ile Phe Val Ala Lys Asp Thr
115 120 125
Ala Thr Gly Arg Ala Thr Pro Val Pro Ser Phe Thr Pro Lys Asn Glu
130 135 140
Glu Glu Gln Arg Val Leu Glu Ala Ala Asn Ser Arg Ile Gly Leu Arg
145 150 155 160
Lys Ala Ile Glu Ala Glu Met Glu Lys Gln Thr Tyr Asn Gly Pro Ser
165 170 175
Glu Ala Pro Arg Leu Ile Thr Arg Phe Leu Ala Lys Pro Thr Asp Ile
180 185 190
Asn Trp Gly Gly Lys Val His Gly Gly Thr Ala Met Glu Trp Ile Asp
195 200 205
Glu Ala Gly Ala Ala Cys Thr Met Glu Trp Ser Gly Asn His Thr Val
210 215 220
Ala Val Tyr Ala Gly Gly Ile Arg Phe Tyr Gln Pro Ile Gln Ile Gly
225 230 235 240
Asp Leu Ile Glu Val Asp Ala Arg Met Met Arg Thr Asp Lys Arg Ser
245 250 255
Met Gln Met Ser Ile His Val Arg Ala Gly Asp Ala His Arg Gly Arg
260 265 270
Ala Glu Leu Glu Thr Ala Ile His Ala Thr Val Thr Tyr Leu Gly Ile
275 280 285
Asp Val Asp Gly Glu Pro Leu Pro Ala Pro Gln Phe Val Pro Arg Thr
290 295 300
Pro Glu Asp Ile Gln Leu Ala Glu His Ala Asn Ile Leu Arg Asp Leu
305 310 315 320
Arg Ala Asp Tyr Thr Pro Met Pro Leu Phe Gln Arg Arg Val Pro Leu
325 330 335
Gln Ile Asp
<210> 231
<211> 313
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(313)
<223> FRXA00559
<400> 231
cccttcaatc cagtctttga cggccaatac ggcttgccgg gtttccagcg gatcaatcct 60
catgaagcat cagcctagta cgaaccgtta aagtgtccat atg tct gat aat ccg 115
Met Ser Asp Asn Pro
1 5
cat gag aat ccc cgt gag aat cca cac cgc tcc cca gaa gtc gtc ctt 163
His Glu Asn Pro Arg Glu Asn Pro His Arg Ser Pro Glu Val Val Leu
10 15 20
cgt ttc atg gct gcc cct act gac gtt ttg atg gct ggt agc cat ggc 211
Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met Ala Gly Ser His Gly
25 30 35
gtt ggc ggt ggc cga gtc ctg gaa tgg atc gat aag gct gct tat gct 259
Val Gly Gly Gly Arg Val Leu Glu Trp Ile Asp Lys Ala Ala Tyr Ala
40 45 50
tgt gct acc cac ggg tct gga acc tac tgc gtc act gct tat gtt ggt 307
Cys Ala Thr His Gly Ser Gly Thr Tyr Cys Val Thr Ala Tyr Val Gly
55 60 65
cac att 313
His Ile
70
<210> 232
<211> 71
<212> PRT
<213> Corynebacterium glutamicum
<400> 232
Met Ser Asp Asn Pro His Glu Asn Pro Arg Glu Asn Pro His Arg Ser
1 5 10 15
Pro Glu Val Val Leu Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met
20 25 30
Ala Gly Ser His Gly Val Gly Gly Gly Arg Val Leu Glu Trp Ile Asp
35 40 45
Lys Ala Ala Tyr Ala Cys Ala Thr His Gly Ser Gly Thr Tyr Cys Val
50 55 60
Thr Ala Tyr Val Gly His Ile
65 70
<210> 233
<211> 802
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(802)
<223> RXA01580
<400> 233
cggtaaacgc ctcattaaag tccaatgcca tgctcataac actaacagtt aaccgtgcgg 60
tcaactttgc tccctatcct taaaaagccc acagaaaagg atg tat aag aat atg 115
Met Tyr Lys Asn Met
1 5
cac att gtt gcc cat cgc ggt gcg gaa gat ctg cac ctc gaa aac acc 163
His Ile Val Ala His Arg Gly Ala Glu Asp Leu His Leu Glu Asn Thr
10 15 20
atg acc gct ttc cag gct gcc gcg ccc gct gac gct ttt gag ctg gat 211
Met Thr Ala Phe Gln Ala Ala Ala Pro Ala Asp Ala Phe Glu Leu Asp
25 30 35
atc cac gcc acc gct gac aat cag gtc gtc gtt atc cac gac cgc acc 259
Ile His Ala Thr Ala Asp Asn Gln Val Val Val Ile His Asp Arg Thr
40 45 50
gca gcg cgt gtt gcc gcg cca gat tcc ctg cac cgc gac acc ccg gtt 307
Ala Ala Arg Val Ala Ala Pro Asp Ser Leu His Arg Asp Thr Pro Val
55 60 65
gcg cgc tta agc gcc gcg caa atc aag gag ata acg ctt atc gac gga 355
Ala Arg Leu Ser Ala Ala Gln Ile Lys Glu Ile Thr Leu Ile Asp Gly
70 75 80 85
tcc ccc gta cca acc ctg gag gaa gtt cta ctc cag acg agc ctg ccg 403
Ser Pro Val Pro Thr Leu Glu Glu Val Leu Leu Gln Thr Ser Leu Pro
90 95 100
atc caa gtg gaa atc aaa tct gcc ggt gca gtt cca gca gcc gca gca 451
Ile Gln Val Glu Ile Lys Ser Ala Gly Ala Val Pro Ala Ala Ala Ala
105 110 115
tta ttg cag aaa tac cca gag cac ctg gag cgc ctg ctg ttc atc agt 499
Leu Leu Gln Lys Tyr Pro Glu His Leu Glu Arg Leu Leu Phe Ile Ser
120 125 130
ttc atc gat gca gca ctg gtg gaa atc gtg gat cga ctg cca gaa gct 547
Phe Ile Asp Ala Ala Leu Val Glu Ile Val Asp Arg Leu Pro Glu Ala
135 140 145
cgc gtg gga atc ttg cgc gat gcg tcc atg gat gat ctg cgc att ctt 595
Arg Val Gly Ile Leu Arg Asp Ala Ser Met Asp Asp Leu Arg Ile Leu
150 155 160 165
gat tac atc ccg cta aaa aat gtg ggc gcg atc ttg ccc tcg tgg aaa 643
Asp Tyr Ile Pro Leu Lys Asn Val Gly Ala Ile Leu Pro Ser Trp Lys
170 175 180
gca cta aac gtg gcg tca att gct gat cta cat acc aag gga atc aag 691
Ala Leu Asn Val Ala Ser Ile Ala Asp Leu His Thr Lys Gly Ile Lys
185 190 195
gtt ggc tgc tgg aca att cgg gat gaa aat gcg ttt ggg atc gca caa 739
Val Gly Cys Trp Thr Ile Arg Asp Glu Asn Ala Phe Gly Ile Ala Gln
200 205 210
caa gct ggc gtt gat tac ccc act gtt agc gat ccc tct cgt ttc tcg 787
Gln Ala Gly Val Asp Tyr Pro Thr Val Ser Asp Pro Ser Arg Phe Ser
215 220 225
cgc cct ccc ctg ctg 802
Arg Pro Pro Leu Leu
230
<210> 234
<211> 234
<212> PRT
<213> Corynebacterium glutamicum
<400> 234
Met Tyr Lys Asn Met His Ile Val Ala His Arg Gly Ala Glu Asp Leu
1 5 10 15
His Leu Glu Asn Thr Met Thr Ala Phe Gln Ala Ala Ala Pro Ala Asp
20 25 30
Ala Phe Glu Leu Asp Ile His Ala Thr Ala Asp Asn Gln Val Val Val
35 40 45
Ile His Asp Arg Thr Ala Ala Arg Val Ala Ala Pro Asp Ser Leu His
50 55 60
Arg Asp Thr Pro Val Ala Arg Leu Ser Ala Ala Gln Ile Lys Glu Ile
65 70 75 80
Thr Leu Ile Asp Gly Ser Pro Val Pro Thr Leu Glu Glu Val Leu Leu
85 90 95
Gln Thr Ser Leu Pro Ile Gln Val Glu Ile Lys Ser Ala Gly Ala Val
100 105 110
Pro Ala Ala Ala Ala Leu Leu Gln Lys Tyr Pro Glu His Leu Glu Arg
115 120 125
Leu Leu Phe Ile Ser Phe Ile Asp Ala Ala Leu Val Glu Ile Val Asp
130 135 140
Arg Leu Pro Glu Ala Arg Val Gly Ile Leu Arg Asp Ala Ser Met Asp
145 150 155 160
Asp Leu Arg Ile Leu Asp Tyr Ile Pro Leu Lys Asn Val Gly Ala Ile
165 170 175
Leu Pro Ser Trp Lys Ala Leu Asn Val Ala Ser Ile Ala Asp Leu His
180 185 190
Thr Lys Gly Ile Lys Val Gly Cys Trp Thr Ile Arg Asp Glu Asn Ala
195 200 205
Phe Gly Ile Ala Gln Gln Ala Gly Val Asp Tyr Pro Thr Val Ser Asp
210 215 220
Pro Ser Arg Phe Ser Arg Pro Pro Leu Leu
225 230
<210> 235
<211> 882
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(859)
<223> RXA02677
<400> 235
ttagtgcagt gtatttattt ccgttcacgc tgcggggctg gtggtttgga gggatactag 60
agtcgatagc aggtatataa aggccaggag agatgggttc atg aaa gtc atc gcg 115
Met Lys Val Ile Ala
1 5
cac cga ggt tta tcg tct cgc ttt ccc gaa tta aca gag tct gcg ttt 163
His Arg Gly Leu Ser Ser Arg Phe Pro Glu Leu Thr Glu Ser Ala Phe
10 15 20
cgg gcg gct cta gag cta ccg att cat gga att gaa act gat gtc cgg 211
Arg Ala Ala Leu Glu Leu Pro Ile His Gly Ile Glu Thr Asp Val Arg
25 30 35
ctg act aaa tgt ggc gaa gtg gtt aac gtc cat gac ccc att gtg gat 259
Leu Thr Lys Cys Gly Glu Val Val Asn Val His Asp Pro Ile Val Asp
40 45 50
cgc gtg tcg aat ggt cgc ggt cgg gtg tcg cgt ttg gac ttg gaa tcc 307
Arg Val Ser Asn Gly Arg Gly Arg Val Ser Arg Leu Asp Leu Glu Ser
55 60 65
ttg ctg agc ttg aac ttt gga acc aaa gaa acc cca gaa aaa gtg ctt 355
Leu Leu Ser Leu Asn Phe Gly Thr Lys Glu Thr Pro Glu Lys Val Leu
70 75 80 85
act tta aac aat cta tta gat att ttt gag gat tat cca gat aag cac 403
Thr Leu Asn Asn Leu Leu Asp Ile Phe Glu Asp Tyr Pro Asp Lys His
90 95 100
ctt tat ata gaa acc aag cac cca atg cgc tac gcg gtc atg ctg gaa 451
Leu Tyr Ile Glu Thr Lys His Pro Met Arg Tyr Ala Val Met Leu Glu
105 110 115
gaa gaa atc aca aaa atc tta aaa tat cgt ggg ctg acg gaa gac cca 499
Glu Glu Ile Thr Lys Ile Leu Lys Tyr Arg Gly Leu Thr Glu Asp Pro
120 125 130
cgc atc cac atc att tct ttt gca ctt ccc gcg atg tat cgc atg gct 547
Arg Ile His Ile Ile Ser Phe Ala Leu Pro Ala Met Tyr Arg Met Ala
135 140 145
cgc ctt gct cca cag ctt gat cgc att cat ctg cgc agg tcg tgg gag 595
Arg Leu Ala Pro Gln Leu Asp Arg Ile His Leu Arg Arg Ser Trp Glu
150 155 160 165
cgt tgg ggt aat ccg cgc gat gtg cgc tgc ggt gta ccc acc ggt ttg 643
Arg Trp Gly Asn Pro Arg Asp Val Arg Cys Gly Val Pro Thr Gly Leu
170 175 180
ggg ttg tcg ctg gag cgg gcg aag atg gat cca agg atg att ggg gcg 691
Gly Leu Ser Leu Glu Arg Ala Lys Met Asp Pro Arg Met Ile Gly Ala
185 190 195
aaa ggg tta ccc acc tat ctt ttc acc gtc gat aag caa aaa gac atg 739
Lys Gly Leu Pro Thr Tyr Leu Phe Thr Val Asp Lys Gln Lys Asp Met
200 205 210
ctg tgg gcg cgc gaa cag ggc gtc gac atg ctc gcc acc aat tat ccg 787
Leu Trp Ala Arg Glu Gln Gly Val Asp Met Leu Ala Thr Asn Tyr Pro
215 220 225
gac cgt gcg gcg gag ctt ttg aac gca cat ccc aag ccc gcc atg tac 835
Asp Arg Ala Ala Glu Leu Leu Asn Ala His Pro Lys Pro Ala Met Tyr
230 235 240 245
gct aat gcg cat ggc aaa gaa gac taagaagaat gaacagctgc cgg 882
Ala Asn Ala His Gly Lys Glu Asp
250
<210> 236
<211> 253
<212> PRT
<213> Corynebacterium glutamicum
<400> 236
Met Lys Val Ile Ala His Arg Gly Leu Ser Ser Arg Phe Pro Glu Leu
1 5 10 15
Thr Glu Ser Ala Phe Arg Ala Ala Leu Glu Leu Pro Ile His Gly Ile
20 25 30
Glu Thr Asp Val Arg Leu Thr Lys Cys Gly Glu Val Val Asn Val His
35 40 45
Asp Pro Ile Val Asp Arg Val Ser Asn Gly Arg Gly Arg Val Ser Arg
50 55 60
Leu Asp Leu Glu Ser Leu Leu Ser Leu Asn Phe Gly Thr Lys Glu Thr
65 70 75 80
Pro Glu Lys Val Leu Thr Leu Asn Asn Leu Leu Asp Ile Phe Glu Asp
85 90 95
Tyr Pro Asp Lys His Leu Tyr Ile Glu Thr Lys His Pro Met Arg Tyr
100 105 110
Ala Val Met Leu Glu Glu Glu Ile Thr Lys Ile Leu Lys Tyr Arg Gly
115 120 125
Leu Thr Glu Asp Pro Arg Ile His Ile Ile Ser Phe Ala Leu Pro Ala
130 135 140
Met Tyr Arg Met Ala Arg Leu Ala Pro Gln Leu Asp Arg Ile His Leu
145 150 155 160
Arg Arg Ser Trp Glu Arg Trp Gly Asn Pro Arg Asp Val Arg Cys Gly
165 170 175
Val Pro Thr Gly Leu Gly Leu Ser Leu Glu Arg Ala Lys Met Asp Pro
180 185 190
Arg Met Ile Gly Ala Lys Gly Leu Pro Thr Tyr Leu Phe Thr Val Asp
195 200 205
Lys Gln Lys Asp Met Leu Trp Ala Arg Glu Gln Gly Val Asp Met Leu
210 215 220
Ala Thr Asn Tyr Pro Asp Arg Ala Ala Glu Leu Leu Asn Ala His Pro
225 230 235 240
Lys Pro Ala Met Tyr Ala Asn Ala His Gly Lys Glu Asp
245 250
<210> 237
<211> 1428
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1405)
<223> RXS01166
<400> 237
accgtaccca cagacacacc agaattaaca gaaacagact gaaaaacaac atcgctcgac 60
atgcgcgtaa tcctaacccg cgcacactaa tgtggccgat atg ggc tac acc aac 115
Met Gly Tyr Thr Asn
1 5
ctc aac gac aca cgg gtc ttg cgc gcc ggg tca tgt gat gcc tgg tgg 163
Leu Asn Asp Thr Arg Val Leu Arg Ala Gly Ser Cys Asp Ala Trp Trp
10 15 20
cgc acg atg tct ccg cta gtg cag cag gga agt gag gca gtc ttt cgg 211
Arg Thr Met Ser Pro Leu Val Gln Gln Gly Ser Glu Ala Val Phe Arg
25 30 35
cgc atc atg ggt ctc tcg cgg cgt cct gat cgg aaa cct ggc ttt gac 259
Arg Ile Met Gly Leu Ser Arg Arg Pro Asp Arg Lys Pro Gly Phe Asp
40 45 50
gat gtc cca cat ttc ggc gca gct gtt cga gtt ccc ggt cta aaa cac 307
Asp Val Pro His Phe Gly Ala Ala Val Arg Val Pro Gly Leu Lys His
55 60 65
ggc acg ttg gtc aat gct gca ccc ttg aaa gtt ttg ggc gca cgg ggc 355
Gly Thr Leu Val Asn Ala Ala Pro Leu Lys Val Leu Gly Ala Arg Gly
70 75 80 85
gag ccc aac ccc gcg agt tcg tac cgt ttt gaa tac atc acc ggt gat 403
Glu Pro Asn Pro Ala Ser Ser Tyr Arg Phe Glu Tyr Ile Thr Gly Asp
90 95 100
tcc gca ggt cga gcc atc act gcg acc ggc gct gtc ctc ttt tcc aca 451
Ser Ala Gly Arg Ala Ile Thr Ala Thr Gly Ala Val Leu Phe Ser Thr
105 110 115
cgc ccc tgg aca acc ggc ccg cgt ccc gcg atc gcc atg gct cca tcc 499
Arg Pro Trp Thr Thr Gly Pro Arg Pro Ala Ile Ala Met Ala Pro Ser
120 125 130
acc caa ggc gtc gca cag cac tgc gat ccc tcc cac acc tgc gcc atc 547
Thr Gln Gly Val Ala Gln His Cys Asp Pro Ser His Thr Cys Ala Ile
135 140 145
gga ctc aac gca ttc tat gac aaa ccc ttc gac gca atc att gct tac 595
Gly Leu Asn Ala Phe Tyr Asp Lys Pro Phe Asp Ala Ile Ile Ala Tyr
150 155 160 165
gaa ctc ccc gtc atc ctc tgg ttt cta gct cac gga ctt gac gtt gtg 643
Glu Leu Pro Val Ile Leu Trp Phe Leu Ala His Gly Leu Asp Val Val
170 175 180
ttc atc gat tac ccc cgc gac ccc gca acc ggc gtc caa tac tat tgc 691
Phe Ile Asp Tyr Pro Arg Asp Pro Ala Thr Gly Val Gln Tyr Tyr Cys
185 190 195
gat tcc atc gct gca gct aaa tcg ctt ctc gac gcc gtc ctc gcc tcc 739
Asp Ser Ile Ala Ala Ala Lys Ser Leu Leu Asp Ala Val Leu Ala Ser
200 205 210
aga caa ctc ggc ctt tca ccg gaa gca ccg ctt ggc ctg tgg gga ttc 787
Arg Gln Leu Gly Leu Ser Pro Glu Ala Pro Leu Gly Leu Trp Gly Phe
215 220 225
tcc caa gga ggc ggc gcc act ggc tgg gct gca caa ttg cag gat tac 835
Ser Gln Gly Gly Gly Ala Thr Gly Trp Ala Ala Gln Leu Gln Asp Tyr
230 235 240 245
gca cct gat gtc cgc cca aag gca gcg gtc gtg ggc gct cca cca gtg 883
Ala Pro Asp Val Arg Pro Lys Ala Ala Val Val Gly Ala Pro Pro Val
250 255 260
gat ctc ttc cgc gtc ttg gac act gtc gac ggc gga ttg ctc acc gga 931
Asp Leu Phe Arg Val Leu Asp Thr Val Asp Gly Gly Leu Leu Thr Gly
265 270 275
gtg att gcc tac gcc atc gcg gga ctt gca gtg aac tct tca gag atg 979
Val Ile Ala Tyr Ala Ile Ala Gly Leu Ala Val Asn Ser Ser Glu Met
280 285 290
ttt gag gaa atc atg tcg gtg tta aat gaa cgc gga gtc agt gat gtg 1027
Phe Glu Glu Ile Met Ser Val Leu Asn Glu Arg Gly Val Ser Asp Val
295 300 305
ctg aaa aat atc acc agc tgc gcg gga ggt tcc ttg ttg gcc agt ggc 1075
Leu Lys Asn Ile Thr Ser Cys Ala Gly Gly Ser Leu Leu Ala Ser Gly
310 315 320 325
tac tcg tct tcc cgc ggg tgg aca cat cag ggc acg ccg ctg gca gac 1123
Tyr Ser Ser Ser Arg Gly Trp Thr His Gln Gly Thr Pro Leu Ala Asp
330 335 340
att ctg gac gat ctg cca ctt gtt gtc gct gag ttt ggg aag caa aag 1171
Ile Leu Asp Asp Leu Pro Leu Val Val Ala Glu Phe Gly Lys Gln Lys
345 350 355
ctg ggt cgt gtg gcg cca gaa atc cca gtg ctg ttg tgg ggc tct aaa 1219
Leu Gly Arg Val Ala Pro Glu Ile Pro Val Leu Leu Trp Gly Ser Lys
360 365 370
aat gat gat gtc att ccc att gat ccc att agg gaa ttg cgt gat agc 1267
Asn Asp Asp Val Ile Pro Ile Asp Pro Ile Arg Glu Leu Arg Asp Ser
375 380 385
tgg gcg gac aag ggt acg cca ttg acc tgg cat gaa tcc caa gcg ccg 1315
Trp Ala Asp Lys Gly Thr Pro Leu Thr Trp His Glu Ser Gln Ala Pro
390 395 400 405
cgt gtg cca gga cgc aca ggt ctc aac cat ttc ggg ccc tat ttt aga 1363
Arg Val Pro Gly Arg Thr Gly Leu Asn His Phe Gly Pro Tyr Phe Arg
410 415 420
aac ctg gaa aag tac tcg gga tgg ctc ata gat cat ctt gtc 1405
Asn Leu Glu Lys Tyr Ser Gly Trp Leu Ile Asp His Leu Val
425 430 435
tgagtgccgt tttaaaggct cgg 1428
<210> 238
<211> 435
<212> PRT
<213> Corynebacterium glutamicum
<400> 238
Met Gly Tyr Thr Asn Leu Asn Asp Thr Arg Val Leu Arg Ala Gly Ser
1 5 10 15
Cys Asp Ala Trp Trp Arg Thr Met Ser Pro Leu Val Gln Gln Gly Ser
20 25 30
Glu Ala Val Phe Arg Arg Ile Met Gly Leu Ser Arg Arg Pro Asp Arg
35 40 45
Lys Pro Gly Phe Asp Asp Val Pro His Phe Gly Ala Ala Val Arg Val
50 55 60
Pro Gly Leu Lys His Gly Thr Leu Val Asn Ala Ala Pro Leu Lys Val
65 70 75 80
Leu Gly Ala Arg Gly Glu Pro Asn Pro Ala Ser Ser Tyr Arg Phe Glu
85 90 95
Tyr Ile Thr Gly Asp Ser Ala Gly Arg Ala Ile Thr Ala Thr Gly Ala
100 105 110
Val Leu Phe Ser Thr Arg Pro Trp Thr Thr Gly Pro Arg Pro Ala Ile
115 120 125
Ala Met Ala Pro Ser Thr Gln Gly Val Ala Gln His Cys Asp Pro Ser
130 135 140
His Thr Cys Ala Ile Gly Leu Asn Ala Phe Tyr Asp Lys Pro Phe Asp
145 150 155 160
Ala Ile Ile Ala Tyr Glu Leu Pro Val Ile Leu Trp Phe Leu Ala His
165 170 175
Gly Leu Asp Val Val Phe Ile Asp Tyr Pro Arg Asp Pro Ala Thr Gly
180 185 190
Val Gln Tyr Tyr Cys Asp Ser Ile Ala Ala Ala Lys Ser Leu Leu Asp
195 200 205
Ala Val Leu Ala Ser Arg Gln Leu Gly Leu Ser Pro Glu Ala Pro Leu
210 215 220
Gly Leu Trp Gly Phe Ser Gln Gly Gly Gly Ala Thr Gly Trp Ala Ala
225 230 235 240
Gln Leu Gln Asp Tyr Ala Pro Asp Val Arg Pro Lys Ala Ala Val Val
245 250 255
Gly Ala Pro Pro Val Asp Leu Phe Arg Val Leu Asp Thr Val Asp Gly
260 265 270
Gly Leu Leu Thr Gly Val Ile Ala Tyr Ala Ile Ala Gly Leu Ala Val
275 280 285
Asn Ser Ser Glu Met Phe Glu Glu Ile Met Ser Val Leu Asn Glu Arg
290 295 300
Gly Val Ser Asp Val Leu Lys Asn Ile Thr Ser Cys Ala Gly Gly Ser
305 310 315 320
Leu Leu Ala Ser Gly Tyr Ser Ser Ser Arg Gly Trp Thr His Gln Gly
325 330 335
Thr Pro Leu Ala Asp Ile Leu Asp Asp Leu Pro Leu Val Val Ala Glu
340 345 350
Phe Gly Lys Gln Lys Leu Gly Arg Val Ala Pro Glu Ile Pro Val Leu
355 360 365
Leu Trp Gly Ser Lys Asn Asp Asp Val Ile Pro Ile Asp Pro Ile Arg
370 375 380
Glu Leu Arg Asp Ser Trp Ala Asp Lys Gly Thr Pro Leu Thr Trp His
385 390 395 400
Glu Ser Gln Ala Pro Arg Val Pro Gly Arg Thr Gly Leu Asn His Phe
405 410 415
Gly Pro Tyr Phe Arg Asn Leu Glu Lys Tyr Ser Gly Trp Leu Ile Asp
420 425 430
His Leu Val
435
<210> 239
<211> 690
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(667)
<223> RXA00875
<400> 239
caatttggcg gcgctgctgg gtgatcgggg gccggttgtt ccgggtgtga ttggtgactg 60
ggtgaggggc taacgcaaca atgtgtctaa gcttaggggc atg act act gag gtt 115
Met Thr Thr Glu Val
1 5
gaa ctg gtt gtt tta gct gat tcc gag ggc aat cct att ggt act gcg 163
Glu Leu Val Val Leu Ala Asp Ser Glu Gly Asn Pro Ile Gly Thr Ala
10 15 20
ccg aaa gct acg gtg cac act aag gac acg cct ctg cat ttc gcg ttt 211
Pro Lys Ala Thr Val His Thr Lys Asp Thr Pro Leu His Phe Ala Phe
25 30 35
tcc acc tat att ttg aac ccg cgt ggg gag ctg ttg gtg acg cgt cgt 259
Ser Thr Tyr Ile Leu Asn Pro Arg Gly Glu Leu Leu Val Thr Arg Arg
40 45 50
gca ttg tcg aag aag aca tgg cct ggt gtg tgg acg aac tct atg tgt 307
Ala Leu Ser Lys Lys Thr Trp Pro Gly Val Trp Thr Asn Ser Met Cys
55 60 65
ggg cac cct ggt ccg gat gag aca aac gcg gat gcg att cgt cgc agg 355
Gly His Pro Gly Pro Asp Glu Thr Asn Ala Asp Ala Ile Arg Arg Arg
70 75 80 85
ggt gtc gat gag ttg ggg ctg gag gta gat tct ttc ttg gat att caa 403
Gly Val Asp Glu Leu Gly Leu Glu Val Asp Ser Phe Leu Asp Ile Gln
90 95 100
gag att ctg cct gat tac cag tac cgt gct gtc gac gcg tcc ggc att 451
Glu Ile Leu Pro Asp Tyr Gln Tyr Arg Ala Val Asp Ala Ser Gly Ile
105 110 115
gtg gag tgg gag ttg tgc ccg gtc cac ctc gtg cgt tta gcg gtg ggg 499
Val Glu Trp Glu Leu Cys Pro Val His Leu Val Arg Leu Ala Val Gly
120 125 130
gaa ttt gtg gag cca ctg gat gat gag gtg gag gag ttc gag tgg gcg 547
Glu Phe Val Glu Pro Leu Asp Asp Glu Val Glu Glu Phe Glu Trp Ala
135 140 145
gaa ccg cag aag ctt ttc gac gct gtt gat gcc aca cca ttt gtg ttt 595
Glu Pro Gln Lys Leu Phe Asp Ala Val Asp Ala Thr Pro Phe Val Phe
150 155 160 165
tct cca tgg cta gtg gat cag ctt agc gcc cct gag ctg cgc caa gcc 643
Ser Pro Trp Leu Val Asp Gln Leu Ser Ala Pro Glu Leu Arg Gln Ala
170 175 180
atc ctg gaa gcg ttt gac gca gag taactaacta gtctagaagc ctt 690
Ile Leu Glu Ala Phe Asp Ala Glu
185
<210> 240
<211> 189
<212> PRT
<213> Corynebacterium glutamicum
<400> 240
Met Thr Thr Glu Val Glu Leu Val Val Leu Ala Asp Ser Glu Gly Asn
1 5 10 15
Pro Ile Gly Thr Ala Pro Lys Ala Thr Val His Thr Lys Asp Thr Pro
20 25 30
Leu His Phe Ala Phe Ser Thr Tyr Ile Leu Asn Pro Arg Gly Glu Leu
35 40 45
Leu Val Thr Arg Arg Ala Leu Ser Lys Lys Thr Trp Pro Gly Val Trp
50 55 60
Thr Asn Ser Met Cys Gly His Pro Gly Pro Asp Glu Thr Asn Ala Asp
65 70 75 80
Ala Ile Arg Arg Arg Gly Val Asp Glu Leu Gly Leu Glu Val Asp Ser
85 90 95
Phe Leu Asp Ile Gln Glu Ile Leu Pro Asp Tyr Gln Tyr Arg Ala Val
100 105 110
Asp Ala Ser Gly Ile Val Glu Trp Glu Leu Cys Pro Val His Leu Val
115 120 125
Arg Leu Ala Val Gly Glu Phe Val Glu Pro Leu Asp Asp Glu Val Glu
130 135 140
Glu Phe Glu Trp Ala Glu Pro Gln Lys Leu Phe Asp Ala Val Asp Ala
145 150 155 160
Thr Pro Phe Val Phe Ser Pro Trp Leu Val Asp Gln Leu Ser Ala Pro
165 170 175
Glu Leu Arg Gln Ala Ile Leu Glu Ala Phe Asp Ala Glu
180 185
<210> 241
<211> 1308
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1285)
<223> RXA01292
<400> 241
tccgcgtccc tcgaagactt aaaaaacggg cgggattttg tgccgtcttt aaaaaagcca 60
gcctggcaac caaagcaatg tggaaagaag tgtttcaaaa atg aca aaa gca gtg 115
Met Thr Lys Ala Val
1 5
gtc atc ggc ggg gga cta gca gga cta gcc acc acc gca ctg ctc tta 163
Val Ile Gly Gly Gly Leu Ala Gly Leu Ala Thr Thr Ala Leu Leu Leu
10 15 20
cgc gaa gga tat gaa gtc cac ctc gtc gaa caa aac gag cac ctc ggc 211
Arg Glu Gly Tyr Glu Val His Leu Val Glu Gln Asn Glu His Leu Gly
25 30 35
ggc cgc gcc ggg acc ttc gaa ctc gac ggc ttc cgc tgg gac acc ggc 259
Gly Arg Ala Gly Thr Phe Glu Leu Asp Gly Phe Arg Trp Asp Thr Gly
40 45 50
ccc agc tgg tac ctc atg ccc gac gcc atg tcc cac ttc ttt aag ctc 307
Pro Ser Trp Tyr Leu Met Pro Asp Ala Met Ser His Phe Phe Lys Leu
55 60 65
tgc ggc acc tcc atc gac gac cac ctc gac ctc gtg cca ctt gaa ccc 355
Cys Gly Thr Ser Ile Asp Asp His Leu Asp Leu Val Pro Leu Glu Pro
70 75 80 85
gcc tac cgc gtc atc gac gac cac ggc gaa ttc atc gac gtc acc tcc 403
Ala Tyr Arg Val Ile Asp Asp His Gly Glu Phe Ile Asp Val Thr Ser
90 95 100
gac atc gat gcg atg gcc gag ctt ttc gaa tcc cgc gaa ccc ggc gcc 451
Asp Ile Asp Ala Met Ala Glu Leu Phe Glu Ser Arg Glu Pro Gly Ala
105 110 115
ggc gcc aaa ctg cgc acc tat atc gac tcc gcc aca cag gtc tac aac 499
Gly Ala Lys Leu Arg Thr Tyr Ile Asp Ser Ala Thr Gln Val Tyr Asn
120 125 130
ctg gcc atc gac ggc ttc ctc tac acc aac ttc acc aac ttc atc cca 547
Leu Ala Ile Asp Gly Phe Leu Tyr Thr Asn Phe Thr Asn Phe Ile Pro
135 140 145
tac tta agc ccc ggc atg ctg cgc ctt tta ccc aaa ctt cta gca agc 595
Tyr Leu Ser Pro Gly Met Leu Arg Leu Leu Pro Lys Leu Leu Ala Ser
150 155 160 165
ctg tcg acc tcg cta aaa gtc aag gtc aac acc caa ttc cgc gat aca 643
Leu Ser Thr Ser Leu Lys Val Lys Val Asn Thr Gln Phe Arg Asp Thr
170 175 180
aaa ctg cgc caa atc tta agc tac ccc gca gtt ttc ctc tcc tca gac 691
Lys Leu Arg Gln Ile Leu Ser Tyr Pro Ala Val Phe Leu Ser Ser Asp
185 190 195
cct tcg cac acc ccg gcg ctc tat cac ctc atg agc cac acc gac ctc 739
Pro Ser His Thr Pro Ala Leu Tyr His Leu Met Ser His Thr Asp Leu
200 205 210
gtc caa ggc gtc tcc tat ccc cga ggc ggc ttc acc gcc ttc atc aag 787
Val Gln Gly Val Ser Tyr Pro Arg Gly Gly Phe Thr Ala Phe Ile Lys
215 220 225
gca cta att tcg ctt atc gac gac gcc gtc ctc cac ctc ggc acc ccc 835
Ala Leu Ile Ser Leu Ile Asp Asp Ala Val Leu His Leu Gly Thr Pro
230 235 240 245
gtc agc gca atc acc acc caa ggc cga aac gcc aca ggc gtc caa gtc 883
Val Ser Ala Ile Thr Thr Gln Gly Arg Asn Ala Thr Gly Val Gln Val
250 255 260
ggc tca gag ttc atc gaa gcc gat atc gtg atc agc tgc gct gat cag 931
Gly Ser Glu Phe Ile Glu Ala Asp Ile Val Ile Ser Cys Ala Asp Gln
265 270 275
cac cac acc gaa acc caa ctc cta cct gct tcg ttg tgc gcg aag ccg 979
His His Thr Glu Thr Gln Leu Leu Pro Ala Ser Leu Cys Ala Lys Pro
280 285 290
gag acg agc tgg aag aac aaa caa ccc ggc ctc agt act gtg ctg gtt 1027
Glu Thr Ser Trp Lys Asn Lys Gln Pro Gly Leu Ser Thr Val Leu Val
295 300 305
ttg gca ggc gtg aag ggg gag cac acc ctg ctt ttt cct ccg act ggg 1075
Leu Ala Gly Val Lys Gly Glu His Thr Leu Leu Phe Pro Pro Thr Gly
310 315 320 325
acg aag att tcc gca aag ttt tcg acg gct cca ccc cag aat tcc cgg 1123
Thr Lys Ile Ser Ala Lys Phe Ser Thr Ala Pro Pro Gln Asn Ser Arg
330 335 340
ctt cag aat cca tct aga tct cca aga cct ccg caa cag att ccg atg 1171
Leu Gln Asn Pro Ser Arg Ser Pro Arg Pro Pro Gln Gln Ile Pro Met
345 350 355
ccg cac ccg aag gcc acg aga acc tct tca tcc tgg tcc cag tac ccg 1219
Pro His Pro Lys Ala Thr Arg Thr Ser Ser Ser Trp Ser Gln Tyr Pro
360 365 370
ccg atg tct cca ttg gtc acg ggt ccg ctt acg gag aag aat ctg aca 1267
Pro Met Ser Pro Leu Val Thr Gly Pro Leu Thr Glu Lys Asn Leu Thr
375 380 385
tgg tgg gcc gga tcg caa tagcagcagt ggctcaaatt ggg 1308
Trp Trp Ala Gly Ser Gln
390 395
<210> 242
<211> 395
<212> PRT
<213> Corynebacterium glutamicum
<400> 242
Met Thr Lys Ala Val Val Ile Gly Gly Gly Leu Ala Gly Leu Ala Thr
1 5 10 15
Thr Ala Leu Leu Leu Arg Glu Gly Tyr Glu Val His Leu Val Glu Gln
20 25 30
Asn Glu His Leu Gly Gly Arg Ala Gly Thr Phe Glu Leu Asp Gly Phe
35 40 45
Arg Trp Asp Thr Gly Pro Ser Trp Tyr Leu Met Pro Asp Ala Met Ser
50 55 60
His Phe Phe Lys Leu Cys Gly Thr Ser Ile Asp Asp His Leu Asp Leu
65 70 75 80
Val Pro Leu Glu Pro Ala Tyr Arg Val Ile Asp Asp His Gly Glu Phe
85 90 95
Ile Asp Val Thr Ser Asp Ile Asp Ala Met Ala Glu Leu Phe Glu Ser
100 105 110
Arg Glu Pro Gly Ala Gly Ala Lys Leu Arg Thr Tyr Ile Asp Ser Ala
115 120 125
Thr Gln Val Tyr Asn Leu Ala Ile Asp Gly Phe Leu Tyr Thr Asn Phe
130 135 140
Thr Asn Phe Ile Pro Tyr Leu Ser Pro Gly Met Leu Arg Leu Leu Pro
145 150 155 160
Lys Leu Leu Ala Ser Leu Ser Thr Ser Leu Lys Val Lys Val Asn Thr
165 170 175
Gln Phe Arg Asp Thr Lys Leu Arg Gln Ile Leu Ser Tyr Pro Ala Val
180 185 190
Phe Leu Ser Ser Asp Pro Ser His Thr Pro Ala Leu Tyr His Leu Met
195 200 205
Ser His Thr Asp Leu Val Gln Gly Val Ser Tyr Pro Arg Gly Gly Phe
210 215 220
Thr Ala Phe Ile Lys Ala Leu Ile Ser Leu Ile Asp Asp Ala Val Leu
225 230 235 240
His Leu Gly Thr Pro Val Ser Ala Ile Thr Thr Gln Gly Arg Asn Ala
245 250 255
Thr Gly Val Gln Val Gly Ser Glu Phe Ile Glu Ala Asp Ile Val Ile
260 265 270
Ser Cys Ala Asp Gln His His Thr Glu Thr Gln Leu Leu Pro Ala Ser
275 280 285
Leu Cys Ala Lys Pro Glu Thr Ser Trp Lys Asn Lys Gln Pro Gly Leu
290 295 300
Ser Thr Val Leu Val Leu Ala Gly Val Lys Gly Glu His Thr Leu Leu
305 310 315 320
Phe Pro Pro Thr Gly Thr Lys Ile Ser Ala Lys Phe Ser Thr Ala Pro
325 330 335
Pro Gln Asn Ser Arg Leu Gln Asn Pro Ser Arg Ser Pro Arg Pro Pro
340 345 350
Gln Gln Ile Pro Met Pro His Pro Lys Ala Thr Arg Thr Ser Ser Ser
355 360 365
Trp Ser Gln Tyr Pro Pro Met Ser Pro Leu Val Thr Gly Pro Leu Thr
370 375 380
Glu Lys Asn Leu Thr Trp Trp Ala Gly Ser Gln
385 390 395
<210> 243
<211> 450
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(427)
<223> RXA01293
<400> 243
cgatgccgca cccgaaggcc acgagaacct cttcatcctg gtcccagtac ccgccgatgt 60
ctccattggt cacgggtccg cttacggaga agaatctgac atg gtg ggc cgg atc 115
Met Val Gly Arg Ile
1 5
gca ata gca gca gtg gct caa att ggg cga tgg gct ggc att gat ggt 163
Ala Ile Ala Ala Val Ala Gln Ile Gly Arg Trp Ala Gly Ile Asp Gly
10 15 20
ttg gaa agc cgc att gtt gtg cag cgc acc atc ggc cct gcc gac ttc 211
Leu Glu Ser Arg Ile Val Val Gln Arg Thr Ile Gly Pro Ala Asp Phe
25 30 35
gca gac cga tac aac tcc tgg agc ggc ggg tcc att ggc ccc tca cac 259
Ala Asp Arg Tyr Asn Ser Trp Ser Gly Gly Ser Ile Gly Pro Ser His
40 45 50
acc ctg gca caa tcg gcg ttc ttt agg ggt tct aac aaa tcc cgc aaa 307
Thr Leu Ala Gln Ser Ala Phe Phe Arg Gly Ser Asn Lys Ser Arg Lys
55 60 65
gta gat ggc ctg tat gac gca ggt gac acc aca gtt cca ggg gtg ggc 355
Val Asp Gly Leu Tyr Asp Ala Gly Asp Thr Thr Val Pro Gly Val Gly
70 75 80 85
gta tct atg tgt ttg atc tct gca gaa aac gtg ctc aag cgt ctc cgc 403
Val Ser Met Cys Leu Ile Ser Ala Glu Asn Val Leu Lys Arg Leu Arg
90 95 100
ggg gac aac agt gtg gat cgg act taacgggact tttttctttt gct 450
Gly Asp Asn Ser Val Asp Arg Thr
105
<210> 244
<211> 109
<212> PRT
<213> Corynebacterium glutamicum
<400> 244
Met Val Gly Arg Ile Ala Ile Ala Ala Val Ala Gln Ile Gly Arg Trp
1 5 10 15
Ala Gly Ile Asp Gly Leu Glu Ser Arg Ile Val Val Gln Arg Thr Ile
20 25 30
Gly Pro Ala Asp Phe Ala Asp Arg Tyr Asn Ser Trp Ser Gly Gly Ser
35 40 45
Ile Gly Pro Ser His Thr Leu Ala Gln Ser Ala Phe Phe Arg Gly Ser
50 55 60
Asn Lys Ser Arg Lys Val Asp Gly Leu Tyr Asp Ala Gly Asp Thr Thr
65 70 75 80
Val Pro Gly Val Gly Val Ser Met Cys Leu Ile Ser Ala Glu Asn Val
85 90 95
Leu Lys Arg Leu Arg Gly Asp Asn Ser Val Asp Arg Thr
100 105
<210> 245
<211> 1386
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1363)
<223> RXA02310
<400> 245
gaaatggaca aaaagctttt tgtttaaccg tagtcgacgg aaggcacttg aagcaccttg 60
ggttagtctt cttgctctcc ggactgagac aatggggttt gtg tct aca act ttt 115
Val Ser Thr Thr Phe
1 5
gat gtg ttg atc atc ggc gcg ggc ccc tca ggt gcc agc gcc gcc gtc 163
Asp Val Leu Ile Ile Gly Ala Gly Pro Ser Gly Ala Ser Ala Ala Val
10 15 20
cat gcg gcc agg act ggg ctt caa aca ttg ctt atc gac gcc tcc tcc 211
His Ala Ala Arg Thr Gly Leu Gln Thr Leu Leu Ile Asp Ala Ser Ser
25 30 35
ttc ccg cgg gat aaa acg tgt ggc gat ggc ctt act ccc cgt gcg att 259
Phe Pro Arg Asp Lys Thr Cys Gly Asp Gly Leu Thr Pro Arg Ala Ile
40 45 50
cac cag cta gaa ctt cta ggt gtt gct gat cag gtt acc ggg gat tat 307
His Gln Leu Glu Leu Leu Gly Val Ala Asp Gln Val Thr Gly Asp Tyr
55 60 65
ttc aac aag ggc ttg aaa ctg cat ggt ttt ggt ggc tct gtt gag gcg 355
Phe Asn Lys Gly Leu Lys Leu His Gly Phe Gly Gly Ser Val Glu Ala
70 75 80 85
ccg tgg ccg gag aca tat ttc acg aat aag ggt tcc gcg atg tcg cgg 403
Pro Trp Pro Glu Thr Tyr Phe Thr Asn Lys Gly Ser Ala Met Ser Arg
90 95 100
atg gag ttc gat gat ttg tta ttc cgc ttg gca aaa tct cat gag gaa 451
Met Glu Phe Asp Asp Leu Leu Phe Arg Leu Ala Lys Ser His Glu Glu
105 110 115
gta acc acg tgg gag aac gcg agc gcc caa gac ccc att ttg agg ggg 499
Val Thr Thr Trp Glu Asn Ala Ser Ala Gln Asp Pro Ile Leu Arg Gly
120 125 130
aat ttc ttg gaa ggc gtt gtg att aat cac gca ggg caa gag aaa acc 547
Asn Phe Leu Glu Gly Val Val Ile Asn His Ala Gly Gln Glu Lys Thr
135 140 145
gtc aag gcg aag cat gtg att att gcc gat ggt gtc cgc tcc cct ttc 595
Val Lys Ala Lys His Val Ile Ile Ala Asp Gly Val Arg Ser Pro Phe
150 155 160 165
ggt aag aaa ctg ggt agg cag tgg caa cgc gat gag gtg tat ggc att 643
Gly Lys Lys Leu Gly Arg Gln Trp Gln Arg Asp Glu Val Tyr Gly Ile
170 175 180
gcg gct cgt gct tat tgt gaa act ccg ctg tct gat gaa ccg tgg att 691
Ala Ala Arg Ala Tyr Cys Glu Thr Pro Leu Ser Asp Glu Pro Trp Ile
185 190 195
cac tcc cat gtg gaa ctg cgc gat gaa gat ggt gtg gtg cag cca gga 739
His Ser His Val Glu Leu Arg Asp Glu Asp Gly Val Val Gln Pro Gly
200 205 210
tat ggg tgg att ttc ccg ctg ggc aac ggc acg gtg aat ttg ggt tgt 787
Tyr Gly Trp Ile Phe Pro Leu Gly Asn Gly Thr Val Asn Leu Gly Cys
215 220 225
ggc gcg ctc tcg acg gat acg aga cca gcg aag atc aat acg aag aaa 835
Gly Ala Leu Ser Thr Asp Thr Arg Pro Ala Lys Ile Asn Thr Lys Lys
230 235 240 245
ttg ttg agc ttc tat gcg ggt cag cgt cgt aaa gca tgg caa ctc ggg 883
Leu Leu Ser Phe Tyr Ala Gly Gln Arg Arg Lys Ala Trp Gln Leu Gly
250 255 260
ccc gag cac gac gtc gcc tct gcc ctg ctg cct atg ggc ggc gcg gtg 931
Pro Glu His Asp Val Ala Ser Ala Leu Leu Pro Met Gly Gly Ala Val
265 270 275
tcg aat gtg gct ggc gcg aac tgg atg ctg atc ggc gat tcc gcc gcg 979
Ser Asn Val Ala Gly Ala Asn Trp Met Leu Ile Gly Asp Ser Ala Ala
280 285 290
tgt gtg aac ccg ctg aac ggc gaa ggc atc gac tat ggc ctg gaa acc 1027
Cys Val Asn Pro Leu Asn Gly Glu Gly Ile Asp Tyr Gly Leu Glu Thr
295 300 305
gcg gcg atg gcc gtc gac acg ctt gtg gaa aac ccc aag cgc gat ttg 1075
Ala Ala Met Ala Val Asp Thr Leu Val Glu Asn Pro Lys Arg Asp Leu
310 315 320 325
acc ttg gta tgg cca cat agg ttg cgc gac gcg tac ggc gag acc ttc 1123
Thr Leu Val Trp Pro His Arg Leu Arg Asp Ala Tyr Gly Glu Thr Phe
330 335 340
atg ttg gcg cgc acg gct gct cga ctg ctg acg tac ccg cag ttt ttg 1171
Met Leu Ala Arg Thr Ala Ala Arg Leu Leu Thr Tyr Pro Gln Phe Leu
345 350 355
ccg atg gct ggg ccg ctc gca ttc cgc ggg ccg ctg caa aag gcc atc 1219
Pro Met Ala Gly Pro Leu Ala Phe Arg Gly Pro Leu Gln Lys Ala Ile
360 365 370
atg ccg gcg gct gcg cgt ttg atg ggc aac ctg atc aca gag gag gat 1267
Met Pro Ala Ala Ala Arg Leu Met Gly Asn Leu Ile Thr Glu Glu Asp
375 380 385
aaa gac ctg ctc gcc agg ggt tgg cag gcc gcc gga tcc gcg att agt 1315
Lys Asp Leu Leu Ala Arg Gly Trp Gln Ala Ala Gly Ser Ala Ile Ser
390 395 400 405
tgg gcg cgg aag ggc tcc cct ctg tgg gac tcg act agt tct ctg gtt 1363
Trp Ala Arg Lys Gly Ser Pro Leu Trp Asp Ser Thr Ser Ser Leu Val
410 415 420
taatcgccga gtgcagcgcg acg 1386
<210> 246
<211> 421
<212> PRT
<213> Corynebacterium glutamicum
<400> 246
Val Ser Thr Thr Phe Asp Val Leu Ile Ile Gly Ala Gly Pro Ser Gly
1 5 10 15
Ala Ser Ala Ala Val His Ala Ala Arg Thr Gly Leu Gln Thr Leu Leu
20 25 30
Ile Asp Ala Ser Ser Phe Pro Arg Asp Lys Thr Cys Gly Asp Gly Leu
35 40 45
Thr Pro Arg Ala Ile His Gln Leu Glu Leu Leu Gly Val Ala Asp Gln
50 55 60
Val Thr Gly Asp Tyr Phe Asn Lys Gly Leu Lys Leu His Gly Phe Gly
65 70 75 80
Gly Ser Val Glu Ala Pro Trp Pro Glu Thr Tyr Phe Thr Asn Lys Gly
85 90 95
Ser Ala Met Ser Arg Met Glu Phe Asp Asp Leu Leu Phe Arg Leu Ala
100 105 110
Lys Ser His Glu Glu Val Thr Thr Trp Glu Asn Ala Ser Ala Gln Asp
115 120 125
Pro Ile Leu Arg Gly Asn Phe Leu Glu Gly Val Val Ile Asn His Ala
130 135 140
Gly Gln Glu Lys Thr Val Lys Ala Lys His Val Ile Ile Ala Asp Gly
145 150 155 160
Val Arg Ser Pro Phe Gly Lys Lys Leu Gly Arg Gln Trp Gln Arg Asp
165 170 175
Glu Val Tyr Gly Ile Ala Ala Arg Ala Tyr Cys Glu Thr Pro Leu Ser
180 185 190
Asp Glu Pro Trp Ile His Ser His Val Glu Leu Arg Asp Glu Asp Gly
195 200 205
Val Val Gln Pro Gly Tyr Gly Trp Ile Phe Pro Leu Gly Asn Gly Thr
210 215 220
Val Asn Leu Gly Cys Gly Ala Leu Ser Thr Asp Thr Arg Pro Ala Lys
225 230 235 240
Ile Asn Thr Lys Lys Leu Leu Ser Phe Tyr Ala Gly Gln Arg Arg Lys
245 250 255
Ala Trp Gln Leu Gly Pro Glu His Asp Val Ala Ser Ala Leu Leu Pro
260 265 270
Met Gly Gly Ala Val Ser Asn Val Ala Gly Ala Asn Trp Met Leu Ile
275 280 285
Gly Asp Ser Ala Ala Cys Val Asn Pro Leu Asn Gly Glu Gly Ile Asp
290 295 300
Tyr Gly Leu Glu Thr Ala Ala Met Ala Val Asp Thr Leu Val Glu Asn
305 310 315 320
Pro Lys Arg Asp Leu Thr Leu Val Trp Pro His Arg Leu Arg Asp Ala
325 330 335
Tyr Gly Glu Thr Phe Met Leu Ala Arg Thr Ala Ala Arg Leu Leu Thr
340 345 350
Tyr Pro Gln Phe Leu Pro Met Ala Gly Pro Leu Ala Phe Arg Gly Pro
355 360 365
Leu Gln Lys Ala Ile Met Pro Ala Ala Ala Arg Leu Met Gly Asn Leu
370 375 380
Ile Thr Glu Glu Asp Lys Asp Leu Leu Ala Arg Gly Trp Gln Ala Ala
385 390 395 400
Gly Ser Ala Ile Ser Trp Ala Arg Lys Gly Ser Pro Leu Trp Asp Ser
405 410 415
Thr Ser Ser Leu Val
420
<210> 247
<211> 1170
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1147)
<223> RXA02718
<400> 247
tccaccaaaa ttcagcccgc atccccctat tcgattgaag gacgtctcct tgagcagttt 60
cgatgcccat gaccttgacc tcgacaaatt tccggaggtc gtg cga gat cgt ttg 115
Val Arg Asp Arg Leu
1 5
acg cag ttc ctc gat gct caa gag cta aca att gct gat atc ggc gct 163
Thr Gln Phe Leu Asp Ala Gln Glu Leu Thr Ile Ala Asp Ile Gly Ala
10 15 20
cct gtc aca gat gct gtg gcc cat ctt cgc agt ttc gtg ctc aat gga 211
Pro Val Thr Asp Ala Val Ala His Leu Arg Ser Phe Val Leu Asn Gly
25 30 35
gga aag cga atc cgt cct ctt tat gcg tgg gct ggt ttc ctg gcg gcg 259
Gly Lys Arg Ile Arg Pro Leu Tyr Ala Trp Ala Gly Phe Leu Ala Ala
40 45 50
caa ggc cat aag aat tct tct gaa aaa ctt gag tcc gtc ctt gac gcc 307
Gln Gly His Lys Asn Ser Ser Glu Lys Leu Glu Ser Val Leu Asp Ala
55 60 65
gca gcg agt ctc gaa ttc atc cag gct tgt gcc ttg att cat gac gat 355
Ala Ala Ser Leu Glu Phe Ile Gln Ala Cys Ala Leu Ile His Asp Asp
70 75 80 85
att atc gat tct tct gat acc cgg cgc gga gcc ccc aca gtt cac cgg 403
Ile Ile Asp Ser Ser Asp Thr Arg Arg Gly Ala Pro Thr Val His Arg
90 95 100
gct gtg gaa gct gat cac cgc gcc aat aat ttc gaa ggc gat ccc gag 451
Ala Val Glu Ala Asp His Arg Ala Asn Asn Phe Glu Gly Asp Pro Glu
105 110 115
cac ttt ggc gtt tca gtc tcg att ttg gct ggc gat atg gca ttg gtg 499
His Phe Gly Val Ser Val Ser Ile Leu Ala Gly Asp Met Ala Leu Val
120 125 130
tgg gca gaa gac atg ctg cag gat tcc ggt ttg agt gca gag gca ttg 547
Trp Ala Glu Asp Met Leu Gln Asp Ser Gly Leu Ser Ala Glu Ala Leu
135 140 145
gcc cgc acg agg gat gct tgg cgt ggc atg cgt act gag gtt att ggc 595
Ala Arg Thr Arg Asp Ala Trp Arg Gly Met Arg Thr Glu Val Ile Gly
150 155 160 165
ggc cag ctg ctt gat att tat cta gag tcg cac gcc aac gag tcg gtg 643
Gly Gln Leu Leu Asp Ile Tyr Leu Glu Ser His Ala Asn Glu Ser Val
170 175 180
gag ctt gcg gat tct gtc aac cgc ttc aaa acg gcc gct tac acg att 691
Glu Leu Ala Asp Ser Val Asn Arg Phe Lys Thr Ala Ala Tyr Thr Ile
185 190 195
gcg cgc cca ttg cac ctg ggc gcc tcc att gct ggc ggt tcg ccg cag 739
Ala Arg Pro Leu His Leu Gly Ala Ser Ile Ala Gly Gly Ser Pro Gln
200 205 210
ctt atc gac gcg ctc ctc cac tac ggc cac gac atc ggc att gca ttc 787
Leu Ile Asp Ala Leu Leu His Tyr Gly His Asp Ile Gly Ile Ala Phe
215 220 225
cag ttg agg gat gat ctg ctt ggt gtg ttt ggg gat ccc gct atc acc 835
Gln Leu Arg Asp Asp Leu Leu Gly Val Phe Gly Asp Pro Ala Ile Thr
230 235 240 245
ggc aaa cca gct gga gac gat atc cgt gaa ggc aag cgc act gtt ctt 883
Gly Lys Pro Ala Gly Asp Asp Ile Arg Glu Gly Lys Arg Thr Val Leu
250 255 260
ctt gcg ctc gct cta caa cgc gct gat aag caa tct cct gaa gct gca 931
Leu Ala Leu Ala Leu Gln Arg Ala Asp Lys Gln Ser Pro Glu Ala Ala
265 270 275
acg gcc att cgc gca ggt gtt gga aag gtg act tca cca gaa gat att 979
Thr Ala Ile Arg Ala Gly Val Gly Lys Val Thr Ser Pro Glu Asp Ile
280 285 290
gct gtc att aca gag cat att cga gct act ggt gct gaa gaa gaa gtt 1027
Ala Val Ile Thr Glu His Ile Arg Ala Thr Gly Ala Glu Glu Glu Val
295 300 305
gag cag cga att tcc cag ctg act gaa tcc ggt ttg gct cac ctc gat 1075
Glu Gln Arg Ile Ser Gln Leu Thr Glu Ser Gly Leu Ala His Leu Asp
310 315 320 325
gat gta gac atc ccc gat gag gtg cgc gca cag ttg cgg gca ctg gct 1123
Asp Val Asp Ile Pro Asp Glu Val Arg Ala Gln Leu Arg Ala Leu Ala
330 335 340
atc cgc tca acc gaa cgt cgg atg tagtagacgc gtatgacact ttt 1170
Ile Arg Ser Thr Glu Arg Arg Met
345
<210> 248
<211> 349
<212> PRT
<213> Corynebacterium glutamicum
<400> 248
Val Arg Asp Arg Leu Thr Gln Phe Leu Asp Ala Gln Glu Leu Thr Ile
1 5 10 15
Ala Asp Ile Gly Ala Pro Val Thr Asp Ala Val Ala His Leu Arg Ser
20 25 30
Phe Val Leu Asn Gly Gly Lys Arg Ile Arg Pro Leu Tyr Ala Trp Ala
35 40 45
Gly Phe Leu Ala Ala Gln Gly His Lys Asn Ser Ser Glu Lys Leu Glu
50 55 60
Ser Val Leu Asp Ala Ala Ala Ser Leu Glu Phe Ile Gln Ala Cys Ala
65 70 75 80
Leu Ile His Asp Asp Ile Ile Asp Ser Ser Asp Thr Arg Arg Gly Ala
85 90 95
Pro Thr Val His Arg Ala Val Glu Ala Asp His Arg Ala Asn Asn Phe
100 105 110
Glu Gly Asp Pro Glu His Phe Gly Val Ser Val Ser Ile Leu Ala Gly
115 120 125
Asp Met Ala Leu Val Trp Ala Glu Asp Met Leu Gln Asp Ser Gly Leu
130 135 140
Ser Ala Glu Ala Leu Ala Arg Thr Arg Asp Ala Trp Arg Gly Met Arg
145 150 155 160
Thr Glu Val Ile Gly Gly Gln Leu Leu Asp Ile Tyr Leu Glu Ser His
165 170 175
Ala Asn Glu Ser Val Glu Leu Ala Asp Ser Val Asn Arg Phe Lys Thr
180 185 190
Ala Ala Tyr Thr Ile Ala Arg Pro Leu His Leu Gly Ala Ser Ile Ala
195 200 205
Gly Gly Ser Pro Gln Leu Ile Asp Ala Leu Leu His Tyr Gly His Asp
210 215 220
Ile Gly Ile Ala Phe Gln Leu Arg Asp Asp Leu Leu Gly Val Phe Gly
225 230 235 240
Asp Pro Ala Ile Thr Gly Lys Pro Ala Gly Asp Asp Ile Arg Glu Gly
245 250 255
Lys Arg Thr Val Leu Leu Ala Leu Ala Leu Gln Arg Ala Asp Lys Gln
260 265 270
Ser Pro Glu Ala Ala Thr Ala Ile Arg Ala Gly Val Gly Lys Val Thr
275 280 285
Ser Pro Glu Asp Ile Ala Val Ile Thr Glu His Ile Arg Ala Thr Gly
290 295 300
Ala Glu Glu Glu Val Glu Gln Arg Ile Ser Gln Leu Thr Glu Ser Gly
305 310 315 320
Leu Ala His Leu Asp Asp Val Asp Ile Pro Asp Glu Val Arg Ala Gln
325 330 335
Leu Arg Ala Leu Ala Ile Arg Ser Thr Glu Arg Arg Met
340 345
<210> 249
<211> 852
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(829)
<223> RXA01067
<400> 249
ggctttaagg ccgaggtgcc tggctgaact gcagcccctc cagaccctga gatcaggcta 60
aatggcaaac acaaatagtt tgcatggcag aatagcttag gtg agt gaa ttc caa 115
Val Ser Glu Phe Gln
1 5
gta ccc gaa atc cct gcc caa ttc cta ccc aag cat att gcg ctt gtc 163
Val Pro Glu Ile Pro Ala Gln Phe Leu Pro Lys His Ile Ala Leu Val
10 15 20
atg gat gga aat gga cgc tgg gct acc gag cgt ggc atg aag cgc acc 211
Met Asp Gly Asn Gly Arg Trp Ala Thr Glu Arg Gly Met Lys Arg Thr
25 30 35
gaa ggc cat aag cgt ggc gag gca gtc ctg ctt gat gtt gtt gat gca 259
Glu Gly His Lys Arg Gly Glu Ala Val Leu Leu Asp Val Val Asp Ala
40 45 50
tgc att gaa ctt ggt gtt ccg tac ctt tct gct tat gcc ttc tct act 307
Cys Ile Glu Leu Gly Val Pro Tyr Leu Ser Ala Tyr Ala Phe Ser Thr
55 60 65
gaa aac tgg cgt cgt tcc acc gat gag gtc cgt ttc ctc atg gga ttc 355
Glu Asn Trp Arg Arg Ser Thr Asp Glu Val Arg Phe Leu Met Gly Phe
70 75 80 85
aac cga gat gtg ctg cga cga caa cgc gat gac cta cat gaa aag ggc 403
Asn Arg Asp Val Leu Arg Arg Gln Arg Asp Asp Leu His Glu Lys Gly
90 95 100
gtt cgt gtg cgt tgg gtt ggc cgt cgt ccc cgc ctg tgg cgt tcg gtt 451
Val Arg Val Arg Trp Val Gly Arg Arg Pro Arg Leu Trp Arg Ser Val
105 110 115
atc cgt gag ctg gaa act gcg gaa gag cta acc aaa gac aac acc acc 499
Ile Arg Glu Leu Glu Thr Ala Glu Glu Leu Thr Lys Asp Asn Thr Thr
120 125 130
atg acc ttg gcc atg tgt gtg aac tat ggt gga cgc gcc gaa atc atc 547
Met Thr Leu Ala Met Cys Val Asn Tyr Gly Gly Arg Ala Glu Ile Ile
135 140 145
gac gca gcc cgc gac atc gcc cgc ctt gca gct gaa ggc aaa ctg cgc 595
Asp Ala Ala Arg Asp Ile Ala Arg Leu Ala Ala Glu Gly Lys Leu Arg
150 155 160 165
ccg gaa caa atc act gag aag acc ttc ccg aac ttc ctc gac gaa cct 643
Pro Glu Gln Ile Thr Glu Lys Thr Phe Pro Asn Phe Leu Asp Glu Pro
170 175 180
gac atg cca gac gtc gac ctg ttc ctg cgc cca tcc ggt gag aag cgc 691
Asp Met Pro Asp Val Asp Leu Phe Leu Arg Pro Ser Gly Glu Lys Arg
185 190 195
acg tca aac ttc ctg ctg tgg cag tct gcc tac gcg gaa atg gtc tac 739
Thr Ser Asn Phe Leu Leu Trp Gln Ser Ala Tyr Ala Glu Met Val Tyr
200 205 210
caa gac aag ctg ttc cct gat ttc acg cag caa gat ctg tac gac gcg 787
Gln Asp Lys Leu Phe Pro Asp Phe Thr Gln Gln Asp Leu Tyr Asp Ala
215 220 225
gtc ctg gaa tac gcc aag cgg gat cgc aga ttc gga agc gca 829
Val Leu Glu Tyr Ala Lys Arg Asp Arg Arg Phe Gly Ser Ala
230 235 240
taatgcccac caaccagccg acg 852
<210> 250
<211> 243
<212> PRT
<213> Corynebacterium glutamicum
<400> 250
Val Ser Glu Phe Gln Val Pro Glu Ile Pro Ala Gln Phe Leu Pro Lys
1 5 10 15
His Ile Ala Leu Val Met Asp Gly Asn Gly Arg Trp Ala Thr Glu Arg
20 25 30
Gly Met Lys Arg Thr Glu Gly His Lys Arg Gly Glu Ala Val Leu Leu
35 40 45
Asp Val Val Asp Ala Cys Ile Glu Leu Gly Val Pro Tyr Leu Ser Ala
50 55 60
Tyr Ala Phe Ser Thr Glu Asn Trp Arg Arg Ser Thr Asp Glu Val Arg
65 70 75 80
Phe Leu Met Gly Phe Asn Arg Asp Val Leu Arg Arg Gln Arg Asp Asp
85 90 95
Leu His Glu Lys Gly Val Arg Val Arg Trp Val Gly Arg Arg Pro Arg
100 105 110
Leu Trp Arg Ser Val Ile Arg Glu Leu Glu Thr Ala Glu Glu Leu Thr
115 120 125
Lys Asp Asn Thr Thr Met Thr Leu Ala Met Cys Val Asn Tyr Gly Gly
130 135 140
Arg Ala Glu Ile Ile Asp Ala Ala Arg Asp Ile Ala Arg Leu Ala Ala
145 150 155 160
Glu Gly Lys Leu Arg Pro Glu Gln Ile Thr Glu Lys Thr Phe Pro Asn
165 170 175
Phe Leu Asp Glu Pro Asp Met Pro Asp Val Asp Leu Phe Leu Arg Pro
180 185 190
Ser Gly Glu Lys Arg Thr Ser Asn Phe Leu Leu Trp Gln Ser Ala Tyr
195 200 205
Ala Glu Met Val Tyr Gln Asp Lys Leu Phe Pro Asp Phe Thr Gln Gln
210 215 220
Asp Leu Tyr Asp Ala Val Leu Glu Tyr Ala Lys Arg Asp Arg Arg Phe
225 230 235 240
Gly Ser Ala
<210> 251
<211> 564
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(541)
<223> RXA01269
<400> 251
gattatctct gcgccgattc agctggcaat agcagcagtt gtattgagag ctcatggtcg 60
tccgattcta tttcgtcaac cacgacctgg gaaagacggt gtg gta ttt gag atg 115
Val Val Phe Glu Met
1 5
att aag ttt cga acc atg ctt gaa cca gat gaa aaa cat gta act gat 163
Ile Lys Phe Arg Thr Met Leu Glu Pro Asp Glu Lys His Val Thr Asp
10 15 20
gaa cag cgt cta act aaa gtt gga aag ctt ctg cgg gaa acg agt tta 211
Glu Gln Arg Leu Thr Lys Val Gly Lys Leu Leu Arg Glu Thr Ser Leu
25 30 35
gat gag tta cct aca ctc tgg aat gta ttt aaa ggt gat atg agc ctt 259
Asp Glu Leu Pro Thr Leu Trp Asn Val Phe Lys Gly Asp Met Ser Leu
40 45 50
gta ggg cct cga cct ttg ctt gtt agc tat ctg gaa cat tac tct tct 307
Val Gly Pro Arg Pro Leu Leu Val Ser Tyr Leu Glu His Tyr Ser Ser
55 60 65
gaa caa gct cga cgc cat gaa gtt cgt cct ggg att act ggt ttg gct 355
Glu Gln Ala Arg Arg His Glu Val Arg Pro Gly Ile Thr Gly Leu Ala
70 75 80 85
cag gtg aat ggc cgt aat caa act act tgg gat gaa cga ctt aag ttg 403
Gln Val Asn Gly Arg Asn Gln Thr Thr Trp Asp Glu Arg Leu Lys Leu
90 95 100
gat gtc gaa tat gtg gat cgc tgt agt ttg aaa cta gat ttc aaa ata 451
Asp Val Glu Tyr Val Asp Arg Cys Ser Leu Lys Leu Asp Phe Lys Ile
105 110 115
tta atc gcc act gta aaa aca gtt ctt tct aaa aag ggc att agt aat 499
Leu Ile Ala Thr Val Lys Thr Val Leu Ser Lys Lys Gly Ile Ser Asn
120 125 130
gaa ggt cat gtc acg atg cca tcc ttc att gaa gaa aga aaa 541
Glu Gly His Val Thr Met Pro Ser Phe Ile Glu Glu Arg Lys
135 140 145
tagcaggtaa aaattttact ttc 564
<210> 252
<211> 147
<212> PRT
<213> Corynebacterium glutamicum
<400> 252
Val Val Phe Glu Met Ile Lys Phe Arg Thr Met Leu Glu Pro Asp Glu
1 5 10 15
Lys His Val Thr Asp Glu Gln Arg Leu Thr Lys Val Gly Lys Leu Leu
20 25 30
Arg Glu Thr Ser Leu Asp Glu Leu Pro Thr Leu Trp Asn Val Phe Lys
35 40 45
Gly Asp Met Ser Leu Val Gly Pro Arg Pro Leu Leu Val Ser Tyr Leu
50 55 60
Glu His Tyr Ser Ser Glu Gln Ala Arg Arg His Glu Val Arg Pro Gly
65 70 75 80
Ile Thr Gly Leu Ala Gln Val Asn Gly Arg Asn Gln Thr Thr Trp Asp
85 90 95
Glu Arg Leu Lys Leu Asp Val Glu Tyr Val Asp Arg Cys Ser Leu Lys
100 105 110
Leu Asp Phe Lys Ile Leu Ile Ala Thr Val Lys Thr Val Leu Ser Lys
115 120 125
Lys Gly Ile Ser Asn Glu Gly His Val Thr Met Pro Ser Phe Ile Glu
130 135 140
Glu Arg Lys
145
<210> 253
<211> 554
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(531)
<223> RXA01205
<400> 253
gta tcg gcc tat ccg ccg gcc atc atc gca gcg gct ctc gta gga att 48
Val Ser Ala Tyr Pro Pro Ala Ile Ile Ala Ala Ala Leu Val Gly Ile
1 5 10 15
tgc gcg gga gtt ttg ccc cat aat ttt gaa ccc tcg cga ata ttt atg 96
Cys Ala Gly Val Leu Pro His Asn Phe Glu Pro Ser Arg Ile Phe Met
20 25 30
ggc gat tcc ggc tcc atg ctc atc ggc ctg ctg ttg gct gca gca tcg 144
Gly Asp Ser Gly Ser Met Leu Ile Gly Leu Leu Leu Ala Ala Ala Ser
35 40 45
acc tca gcg tca gga aaa atc aac atg agc ctg tat ggc gca gct gat 192
Thr Ser Ala Ser Gly Lys Ile Asn Met Ser Leu Tyr Gly Ala Ala Asp
50 55 60
ttt atc gca ttg atc tca ccc atc atc gtt gtt ctc gcc gcc gtg gcc 240
Phe Ile Ala Leu Ile Ser Pro Ile Ile Val Val Leu Ala Ala Val Ala
65 70 75 80
atc cca ctg ctc gac ctc gtg atg gca gtg gtt agg cgc gtg ggc agg 288
Ile Pro Leu Leu Asp Leu Val Met Ala Val Val Arg Arg Val Gly Arg
85 90 95
gga gca tca ccc ttt tcc ccg gac aaa atg cat ctg cac cac cga ctg 336
Gly Ala Ser Pro Phe Ser Pro Asp Lys Met His Leu His His Arg Leu
100 105 110
ctg tcc atc gga cac acc cat agg cgc gtg gtc cta gtg ctc tac acc 384
Leu Ser Ile Gly His Thr His Arg Arg Val Val Leu Val Leu Tyr Thr
115 120 125
tgg gcg agc gcc gtg gca ttc ggc gca gtg agc ttc tcc gtc gtt ccg 432
Trp Ala Ser Ala Val Ala Phe Gly Ala Val Ser Phe Ser Val Val Pro
130 135 140
cca ctg ttt gcc acc gga tcg agc atc tgt ggc atc ctc atc gcc gtc 480
Pro Leu Phe Ala Thr Gly Ser Ser Ile Cys Gly Ile Leu Ile Ala Val
145 150 155 160
gct gtc aca gcc gtg cca gtg atg aaa agc cgg cga gcc gcc aaa ctt 528
Ala Val Thr Ala Val Pro Val Met Lys Ser Arg Arg Ala Ala Lys Leu
165 170 175
gat taagtgattg tcactttgga ttg 554
Asp
<210> 254
<211> 177
<212> PRT
<213> Corynebacterium glutamicum
<400> 254
Val Ser Ala Tyr Pro Pro Ala Ile Ile Ala Ala Ala Leu Val Gly Ile
1 5 10 15
Cys Ala Gly Val Leu Pro His Asn Phe Glu Pro Ser Arg Ile Phe Met
20 25 30
Gly Asp Ser Gly Ser Met Leu Ile Gly Leu Leu Leu Ala Ala Ala Ser
35 40 45
Thr Ser Ala Ser Gly Lys Ile Asn Met Ser Leu Tyr Gly Ala Ala Asp
50 55 60
Phe Ile Ala Leu Ile Ser Pro Ile Ile Val Val Leu Ala Ala Val Ala
65 70 75 80
Ile Pro Leu Leu Asp Leu Val Met Ala Val Val Arg Arg Val Gly Arg
85 90 95
Gly Ala Ser Pro Phe Ser Pro Asp Lys Met His Leu His His Arg Leu
100 105 110
Leu Ser Ile Gly His Thr His Arg Arg Val Val Leu Val Leu Tyr Thr
115 120 125
Trp Ala Ser Ala Val Ala Phe Gly Ala Val Ser Phe Ser Val Val Pro
130 135 140
Pro Leu Phe Ala Thr Gly Ser Ser Ile Cys Gly Ile Leu Ile Ala Val
145 150 155 160
Ala Val Thr Ala Val Pro Val Met Lys Ser Arg Arg Ala Ala Lys Leu
165 170 175
Asp
<210> 255
<211> 882
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(859)
<223> RXA01576
<400> 255
atcggtgatc tttcgcgatt gatacgtgcg cgattgcgtg cccgccagct gctcaagatc 60
aatggatttc atgacaatca agttatcatc actggggtcg gtg gca cct aac agg 115
Val Ala Pro Asn Arg
1 5
aaa atc agc cat cat gca cta ggc tct att cct atc atg gat gca tca 163
Lys Ile Ser His His Ala Leu Gly Ser Ile Pro Ile Met Asp Ala Ser
10 15 20
aaa aac agc gac ttt aaa gac acc tgg cta gtc gta cct tgt tat aac 211
Lys Asn Ser Asp Phe Lys Asp Thr Trp Leu Val Val Pro Cys Tyr Asn
25 30 35
gag gca aca gtt atc cgg gaa gtt tta gag aac gca ctc aaa aca ttc 259
Glu Ala Thr Val Ile Arg Glu Val Leu Glu Asn Ala Leu Lys Thr Phe
40 45 50
cct aat att gtt gcg gtc aac gat ggc tcc ccg gac aac tcc gcg gaa 307
Pro Asn Ile Val Ala Val Asn Asp Gly Ser Pro Asp Asn Ser Ala Glu
55 60 65
gaa atc cat gcg gcc ggc gca cac ctg gtc aac cac ccc gtg aac ctc 355
Glu Ile His Ala Ala Gly Ala His Leu Val Asn His Pro Val Asn Leu
70 75 80 85
gga caa ggt gcc gcg atc caa acc ggc atc gaa tac gcc cgc aag caa 403
Gly Gln Gly Ala Ala Ile Gln Thr Gly Ile Glu Tyr Ala Arg Lys Gln
90 95 100
ccc ggt gca aaa tac ttt gta act ttc gac gcc gac ggc caa cac caa 451
Pro Gly Ala Lys Tyr Phe Val Thr Phe Asp Ala Asp Gly Gln His Gln
105 110 115
gtg aaa gac gtt atc cgc atg gtg gag cga ctg cgt gcc gag gac gtg 499
Val Lys Asp Val Ile Arg Met Val Glu Arg Leu Arg Ala Glu Asp Val
120 125 130
gac att atc gtc ggc acg cgt ttt gga cgc cca cgc caa gcc gat gac 547
Asp Ile Ile Val Gly Thr Arg Phe Gly Arg Pro Arg Gln Ala Asp Asp
135 140 145
cag gtg cca cta atc aag cgc ctt gtg ctg cgc acc gtg gtc ctg ctg 595
Gln Val Pro Leu Ile Lys Arg Leu Val Leu Arg Thr Val Val Leu Leu
150 155 160 165
tca ccg aaa acc cgc cga ctt ggg ctc acc gac gcc cac aac ggc ctg 643
Ser Pro Lys Thr Arg Arg Leu Gly Leu Thr Asp Ala His Asn Gly Leu
170 175 180
cgc gta ttc aac caa aaa gtg gcg cag gaa atg aac atc cgc atg aac 691
Arg Val Phe Asn Gln Lys Val Ala Gln Glu Met Asn Ile Arg Met Asn
185 190 195
ggc atg tcg cat gca tcc gaa atc gtc gac caa atc gat gaa cgc ggc 739
Gly Met Ser His Ala Ser Glu Ile Val Asp Gln Ile Asp Glu Arg Gly
200 205 210
tgg cgc att tca gaa gaa ccc gta gac atc ctc tac acc gaa tac tcc 787
Trp Arg Ile Ser Glu Glu Pro Val Asp Ile Leu Tyr Thr Glu Tyr Ser
215 220 225
atg agc aag ggg caa tcc ctg ctc aac ggc gta aac atc ctg gcc gac 835
Met Ser Lys Gly Gln Ser Leu Leu Asn Gly Val Asn Ile Leu Ala Asp
230 235 240 245
ggc ttc cta gcg agg aga ctc cca tgacgcagac caccacccaa atc 882
Gly Phe Leu Ala Arg Arg Leu Pro
250
<210> 256
<211> 253
<212> PRT
<213> Corynebacterium glutamicum
<400> 256
Val Ala Pro Asn Arg Lys Ile Ser His His Ala Leu Gly Ser Ile Pro
1 5 10 15
Ile Met Asp Ala Ser Lys Asn Ser Asp Phe Lys Asp Thr Trp Leu Val
20 25 30
Val Pro Cys Tyr Asn Glu Ala Thr Val Ile Arg Glu Val Leu Glu Asn
35 40 45
Ala Leu Lys Thr Phe Pro Asn Ile Val Ala Val Asn Asp Gly Ser Pro
50 55 60
Asp Asn Ser Ala Glu Glu Ile His Ala Ala Gly Ala His Leu Val Asn
65 70 75 80
His Pro Val Asn Leu Gly Gln Gly Ala Ala Ile Gln Thr Gly Ile Glu
85 90 95
Tyr Ala Arg Lys Gln Pro Gly Ala Lys Tyr Phe Val Thr Phe Asp Ala
100 105 110
Asp Gly Gln His Gln Val Lys Asp Val Ile Arg Met Val Glu Arg Leu
115 120 125
Arg Ala Glu Asp Val Asp Ile Ile Val Gly Thr Arg Phe Gly Arg Pro
130 135 140
Arg Gln Ala Asp Asp Gln Val Pro Leu Ile Lys Arg Leu Val Leu Arg
145 150 155 160
Thr Val Val Leu Leu Ser Pro Lys Thr Arg Arg Leu Gly Leu Thr Asp
165 170 175
Ala His Asn Gly Leu Arg Val Phe Asn Gln Lys Val Ala Gln Glu Met
180 185 190
Asn Ile Arg Met Asn Gly Met Ser His Ala Ser Glu Ile Val Asp Gln
195 200 205
Ile Asp Glu Arg Gly Trp Arg Ile Ser Glu Glu Pro Val Asp Ile Leu
210 215 220
Tyr Thr Glu Tyr Ser Met Ser Lys Gly Gln Ser Leu Leu Asn Gly Val
225 230 235 240
Asn Ile Leu Ala Asp Gly Phe Leu Ala Arg Arg Leu Pro
245 250
<210> 257
<211> 1173
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1150)
<223> RXN02309
<400> 257
gtgccttccg tcgactacgg ttaaacaaaa agctttttgt ccatttcact ggattcaccg 60
aaagaatgaa tccacactcg atcaccaaag gtagcgatga atg agt agc ggc cga 115
Met Ser Ser Gly Arg
1 5
acc gtt cca acc cgt tcc cac ggg ctc gga aaa gaa ggt gta tcc acc 163
Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys Glu Gly Val Ser Thr
10 15 20
aca gga gca tct cag gtc gag ttt ggt gat ccc gag cta acg gcc agg 211
Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro Glu Leu Thr Ala Arg
25 30 35
atc aat gac gcc atg gtg cag gta gaa gaa ctc ctg cac act gaa cta 259
Ile Asn Asp Ala Met Val Gln Val Glu Glu Leu Leu His Thr Glu Leu
40 45 50
tcg tcc ggg gaa gac ttc ctc gtc gat atc gtc atg cac cta aca cga 307
Ser Ser Gly Glu Asp Phe Leu Val Asp Ile Val Met His Leu Thr Arg
55 60 65
gcc ggc ggc aaa cga ttc cgc ccc atg ttt gca ctg ctg gcc tcc gag 355
Ala Gly Gly Lys Arg Phe Arg Pro Met Phe Ala Leu Leu Ala Ser Glu
70 75 80 85
ttc ggt gaa aaa cca ctc tcc gaa aac gtc atc aaa gcc gcc gtt gtc 403
Phe Gly Glu Lys Pro Leu Ser Glu Asn Val Ile Lys Ala Ala Val Val
90 95 100
gta gag atc acc cac ctg gcc acc ctg tac cac gac gat gtc atg gac 451
Val Glu Ile Thr His Leu Ala Thr Leu Tyr His Asp Asp Val Met Asp
105 110 115
gag gca tcc atg cgc cgc ggc gtc cca agt gct aac gcg cga tgg gac 499
Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala Asn Ala Arg Trp Asp
120 125 130
aac tcc gta gcc atc ctc gca ggc gac atc ctc cta gca cat gca tca 547
Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu Leu Ala His Ala Ser
135 140 145
ggt ctg atg agt cag ctg ggt acc gac aca gtc gcc cac ttt gcc gaa 595
Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val Ala His Phe Ala Glu
150 155 160 165
aca ttc ggc gaa cta gtc acc ggc caa atg cgc gaa aca gtc ggg cca 643
Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg Glu Thr Val Gly Pro
170 175 180
cgc gac acc gac ccg atc gag cac tac acc aac gta atc cgt gaa aaa 691
Arg Asp Thr Asp Pro Ile Glu His Tyr Thr Asn Val Ile Arg Glu Lys
185 190 195
act ggt gtc ctc atc gcc tcc gca ggc tat ttg gga gcc atg cac gca 739
Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu Gly Ala Met His Ala
200 205 210
ggc gcc gca cct gaa cac atc gac gcc ctg aag aac ttc ggc gca gcc 787
Gly Ala Ala Pro Glu His Ile Asp Ala Leu Lys Asn Phe Gly Ala Ala
215 220 225
gtc ggc atg atc ttc caa atc gtc gac gac atc atc gac atc ttc tcg 835
Val Gly Met Ile Phe Gln Ile Val Asp Asp Ile Ile Asp Ile Phe Ser
230 235 240 245
gaa acc cac gaa tcc gga aaa acg ccc ggc acc gac ctc cgc gaa ggt 883
Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr Asp Leu Arg Glu Gly
250 255 260
gta ttc acc ctc cca gtg ctc tac gca ctc cgt gaa gac acc ccc gtc 931
Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg Glu Asp Thr Pro Val
265 270 275
ggc gca gaa ctc cgc gac atc ctc acc ggc cct cta gaa gac gac gag 979
Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro Leu Glu Asp Asp Glu
280 285 290
acc gtc aac cac gtc ctc gag ctc ctc tcc caa tcc ggc gga cgc caa 1027
Thr Val Asn His Val Leu Glu Leu Leu Ser Gln Ser Gly Gly Arg Gln
295 300 305
gca gcc ctc gac gag gtc tac cgc tac atg gac atc gcc aac gca gaa 1075
Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp Ile Ala Asn Ala Glu
310 315 320 325
ctc gac cgc ctc cca gac agc acc gtc aag gaa gcc ctc cgc aac ctt 1123
Leu Asp Arg Leu Pro Asp Ser Thr Val Lys Glu Ala Leu Arg Asn Leu
330 335 340
gca acc ttc aca gtc aag cgc gtc gga taaccccgta atccaccact 1170
Ala Thr Phe Thr Val Lys Arg Val Gly
345 350
taa 1173
<210> 258
<211> 350
<212> PRT
<213> Corynebacterium glutamicum
<400> 258
Met Ser Ser Gly Arg Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys
1 5 10 15
Glu Gly Val Ser Thr Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro
20 25 30
Glu Leu Thr Ala Arg Ile Asn Asp Ala Met Val Gln Val Glu Glu Leu
35 40 45
Leu His Thr Glu Leu Ser Ser Gly Glu Asp Phe Leu Val Asp Ile Val
50 55 60
Met His Leu Thr Arg Ala Gly Gly Lys Arg Phe Arg Pro Met Phe Ala
65 70 75 80
Leu Leu Ala Ser Glu Phe Gly Glu Lys Pro Leu Ser Glu Asn Val Ile
85 90 95
Lys Ala Ala Val Val Val Glu Ile Thr His Leu Ala Thr Leu Tyr His
100 105 110
Asp Asp Val Met Asp Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala
115 120 125
Asn Ala Arg Trp Asp Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu
130 135 140
Leu Ala His Ala Ser Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val
145 150 155 160
Ala His Phe Ala Glu Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg
165 170 175
Glu Thr Val Gly Pro Arg Asp Thr Asp Pro Ile Glu His Tyr Thr Asn
180 185 190
Val Ile Arg Glu Lys Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu
195 200 205
Gly Ala Met His Ala Gly Ala Ala Pro Glu His Ile Asp Ala Leu Lys
210 215 220
Asn Phe Gly Ala Ala Val Gly Met Ile Phe Gln Ile Val Asp Asp Ile
225 230 235 240
Ile Asp Ile Phe Ser Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr
245 250 255
Asp Leu Arg Glu Gly Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg
260 265 270
Glu Asp Thr Pro Val Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro
275 280 285
Leu Glu Asp Asp Glu Thr Val Asn His Val Leu Glu Leu Leu Ser Gln
290 295 300
Ser Gly Gly Arg Gln Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp
305 310 315 320
Ile Ala Asn Ala Glu Leu Asp Arg Leu Pro Asp Ser Thr Val Lys Glu
325 330 335
Ala Leu Arg Asn Leu Ala Thr Phe Thr Val Lys Arg Val Gly
340 345 350
<210> 259
<211> 1075
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1075)
<223> FRXA02309
<400> 259
gtgccttccg tcgactacgg ttaaacaaaa agctttttgt ccatttcact ggattcaccg 60
aaagaatgaa tccacactcg atcaccaaag gtagcgatga atg agt agc ggc cga 115
Met Ser Ser Gly Arg
1 5
acc gtt cca acc cgt tcc cac ggg ctc gga aaa gaa ggt gta tcc acc 163
Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys Glu Gly Val Ser Thr
10 15 20
aca gga gca tct cag gtc gag ttt ggt gat ccc gag cta acg gcc agg 211
Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro Glu Leu Thr Ala Arg
25 30 35
atc aat gac gcc atg gtg cag gta gaa gaa ctc ctg cac act gaa cta 259
Ile Asn Asp Ala Met Val Gln Val Glu Glu Leu Leu His Thr Glu Leu
40 45 50
tcg tcc ggg gaa gac ttc ctc gtc gat atc gtc atg cac cta aca cga 307
Ser Ser Gly Glu Asp Phe Leu Val Asp Ile Val Met His Leu Thr Arg
55 60 65
gcc ggc ggc aaa cga ttc cgc ccc atg ttt gca ctg ctg gcc tcc gag 355
Ala Gly Gly Lys Arg Phe Arg Pro Met Phe Ala Leu Leu Ala Ser Glu
70 75 80 85
ttc ggt gaa aaa cca ctc tcc gaa aac gtc atc aaa gcc gcc gtt gtc 403
Phe Gly Glu Lys Pro Leu Ser Glu Asn Val Ile Lys Ala Ala Val Val
90 95 100
gta gag atc acc cac ctg gcc acc ctg tac cac gac gat gtc atg gac 451
Val Glu Ile Thr His Leu Ala Thr Leu Tyr His Asp Asp Val Met Asp
105 110 115
gag gca tcc atg cgc cgc ggc gtc cca agt gct aac gcg cga tgg gac 499
Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala Asn Ala Arg Trp Asp
120 125 130
aac tcc gta gcc atc ctc gca ggc gac atc ctc cta gca cat gca tca 547
Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu Leu Ala His Ala Ser
135 140 145
ggt ctg atg agt cag ctg ggt acc gac aca gtc gcc cac ttt gcc gaa 595
Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val Ala His Phe Ala Glu
150 155 160 165
aca ttc ggc gaa cta gtc acc ggc caa atg cgc gaa aca gtc ggg cca 643
Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg Glu Thr Val Gly Pro
170 175 180
cgc gac acc gac ccg atc gag cac tac acc aac gta atc cgt gaa aaa 691
Arg Asp Thr Asp Pro Ile Glu His Tyr Thr Asn Val Ile Arg Glu Lys
185 190 195
act ggt gtc ctc atc gcc tcc gca ggc tat ttg gga gcc atg cac gca 739
Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu Gly Ala Met His Ala
200 205 210
ggc gcc gca cct gaa cac atc gac gcc ctg aag aac ttc ggc gca gcc 787
Gly Ala Ala Pro Glu His Ile Asp Ala Leu Lys Asn Phe Gly Ala Ala
215 220 225
gtc ggc atg atc ttc caa atc gtc gac gac atc atc gac atc ttc tcg 835
Val Gly Met Ile Phe Gln Ile Val Asp Asp Ile Ile Asp Ile Phe Ser
230 235 240 245
gaa acc cac gaa tcc gga aaa acg ccc ggc acc gac ctc cgc gaa ggt 883
Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr Asp Leu Arg Glu Gly
250 255 260
gta ttc acc ctc cca gtg ctc tac gca ctc cgt gaa gac acc ccc gtc 931
Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg Glu Asp Thr Pro Val
265 270 275
ggc gca gaa ctc cgc gac atc ctc acc ggc cct cta gaa gac gac gag 979
Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro Leu Glu Asp Asp Glu
280 285 290
acc gtc aac cac gtc ctc gag ctc ctc tcc caa tcc ggc gga cgc caa 1027
Thr Val Asn His Val Leu Glu Leu Leu Ser Gln Ser Gly Gly Arg Gln
295 300 305
gca gcc ctc gac gag gtc tac cgc tac atg gac atc gcc aac gca gaa 1075
Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp Ile Ala Asn Ala Glu
310 315 320 325
<210> 260
<211> 325
<212> PRT
<213> Corynebacterium glutamicum
<400> 260
Met Ser Ser Gly Arg Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys
1 5 10 15
Glu Gly Val Ser Thr Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro
20 25 30
Glu Leu Thr Ala Arg Ile Asn Asp Ala Met Val Gln Val Glu Glu Leu
35 40 45
Leu His Thr Glu Leu Ser Ser Gly Glu Asp Phe Leu Val Asp Ile Val
50 55 60
Met His Leu Thr Arg Ala Gly Gly Lys Arg Phe Arg Pro Met Phe Ala
65 70 75 80
Leu Leu Ala Ser Glu Phe Gly Glu Lys Pro Leu Ser Glu Asn Val Ile
85 90 95
Lys Ala Ala Val Val Val Glu Ile Thr His Leu Ala Thr Leu Tyr His
100 105 110
Asp Asp Val Met Asp Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala
115 120 125
Asn Ala Arg Trp Asp Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu
130 135 140
Leu Ala His Ala Ser Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val
145 150 155 160
Ala His Phe Ala Glu Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg
165 170 175
Glu Thr Val Gly Pro Arg Asp Thr Asp Pro Ile Glu His Tyr Thr Asn
180 185 190
Val Ile Arg Glu Lys Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu
195 200 205
Gly Ala Met His Ala Gly Ala Ala Pro Glu His Ile Asp Ala Leu Lys
210 215 220
Asn Phe Gly Ala Ala Val Gly Met Ile Phe Gln Ile Val Asp Asp Ile
225 230 235 240
Ile Asp Ile Phe Ser Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr
245 250 255
Asp Leu Arg Glu Gly Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg
260 265 270
Glu Asp Thr Pro Val Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro
275 280 285
Leu Glu Asp Asp Glu Thr Val Asn His Val Leu Glu Leu Leu Ser Gln
290 295 300
Ser Gly Gly Arg Gln Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp
305 310 315 320
Ile Ala Asn Ala Glu
325
<210> 261
<211> 1767
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1744)
<223> RXN00477
<400> 261
tgcgggagcg aatcagagtt ccacttcata tcaaactctc tacactcgct agagccacga 60
tgaaaggtct atctatgagc atctacagaa agaattcgtg atg aag gtc tcg act 115
Met Lys Val Ser Thr
1 5
aaa act cca cgc tcc tca ggt acc gcc gta gtc ata ggc gca ggt gtt 163
Lys Thr Pro Arg Ser Ser Gly Thr Ala Val Val Ile Gly Ala Gly Val
10 15 20
gct ggt tta gcc act tct gca ctt tta gca cgt gat ggc tgg caa gta 211
Ala Gly Leu Ala Thr Ser Ala Leu Leu Ala Arg Asp Gly Trp Gln Val
25 30 35
act gtt ttg gaa aaa aat act gat gtc ggt ggc cga gct gga tcg ctt 259
Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly Arg Ala Gly Ser Leu
40 45 50
gaa ata tca ggc ttt cct ggc ttt cga tgg gat acc gga cct tct tgg 307
Glu Ile Ser Gly Phe Pro Gly Phe Arg Trp Asp Thr Gly Pro Ser Trp
55 60 65
tac ctc atg ccc gag gcc ttt gac cat ttc ttc gca ctt ttt ggt gca 355
Tyr Leu Met Pro Glu Ala Phe Asp His Phe Phe Ala Leu Phe Gly Ala
70 75 80 85
tgt act tct gat tat ctc gat ttg gta gaa tta acg cct ggt tat cga 403
Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu Thr Pro Gly Tyr Arg
90 95 100
gtt ttt tct ggc aca cat gac gct gtc gat gtc ccc act ggg cgt gaa 451
Val Phe Ser Gly Thr His Asp Ala Val Asp Val Pro Thr Gly Arg Glu
105 110 115
gaa gca att gcg cta ttc gaa tcc atc gaa ccc ggc gcg ggt gca aaa 499
Glu Ala Ile Ala Leu Phe Glu Ser Ile Glu Pro Gly Ala Gly Ala Lys
120 125 130
cta gga aat tat ctt gat agc gcg gca gac gcc tat gac att gcc att 547
Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala Tyr Asp Ile Ala Ile
135 140 145
gat aga ttc ctt tat aat aat ttc tcc acg tta ggc ccg ctg ctt cac 595
Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu Gly Pro Leu Leu His
150 155 160 165
cgg gat gta ctg acc cga gct ggc cga ctg ttt tct cta ctg acc cgt 643
Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe Ser Leu Leu Thr Arg
170 175 180
tct tta caa aag tac gta aat agt caa ttc agt agc ccg gtg ttg cgc 691
Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser Ser Pro Val Leu Arg
185 190 195
cag atc cta acc tat cca gca gtc ttc ctg tct tcc cga ccc act act 739
Gln Ile Leu Thr Tyr Pro Ala Val Phe Leu Ser Ser Arg Pro Thr Thr
200 205 210
acc cca tcg atg tac cac ttg atg agt cat acc gat ttg gtg cag gga 787
Thr Pro Ser Met Tyr His Leu Met Ser His Thr Asp Leu Val Gln Gly
215 220 225
gtg aaa tac cct ata ggt ggt ttt act gca gtg gtt aac gct ctg cat 835
Val Lys Tyr Pro Ile Gly Gly Phe Thr Ala Val Val Asn Ala Leu His
230 235 240 245
cag tta gcg ctg gaa aac ggg gtt gag ttt caa ctc gat tct gag gtc 883
Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln Leu Asp Ser Glu Val
250 255 260
att tcc atc aac act gct tca tcg agg ggc aac aca agc gcc aca ggt 931
Ile Ser Ile Asn Thr Ala Ser Ser Arg Gly Asn Thr Ser Ala Thr Gly
265 270 275
gtg agc ttg ctt cac aac aga aaa gtg caa aat cta gat gcg gat ctt 979
Val Ser Leu Leu His Asn Arg Lys Val Gln Asn Leu Asp Ala Asp Leu
280 285 290
gtg gtt tca gca ggc gac cta cac cat aca gaa aat aat ctg ctt ccc 1027
Val Val Ser Ala Gly Asp Leu His His Thr Glu Asn Asn Leu Leu Pro
295 300 305
cgg gaa ctt cga acc tat ccc gaa cga tat tgg tcc aat cgc aat cct 1075
Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp Ser Asn Arg Asn Pro
310 315 320 325
gga att gga gcg gta tta atc ctc ctg ggc gta aaa gga gag tta ccc 1123
Gly Ile Gly Ala Val Leu Ile Leu Leu Gly Val Lys Gly Glu Leu Pro
330 335 340
cag ctc gac cat cac aac ctt ttc ttc agt gaa gat tgg aca gat gat 1171
Gln Leu Asp His His Asn Leu Phe Phe Ser Glu Asp Trp Thr Asp Asp
345 350 355
ttt gct gta gtt ttc gac ggg cct caa ctt acc cgc ccc cac aat gca 1219
Phe Ala Val Val Phe Asp Gly Pro Gln Leu Thr Arg Pro His Asn Ala
360 365 370
tca aat tcc att tat gtc tcc aag cct tca acg tcc gaa gac ggc gtt 1267
Ser Asn Ser Ile Tyr Val Ser Lys Pro Ser Thr Ser Glu Asp Gly Val
375 380 385
gca cct gct gga tac gaa aac ctt ttt gtt tta att ccg acc aag gcc 1315
Ala Pro Ala Gly Tyr Glu Asn Leu Phe Val Leu Ile Pro Thr Lys Ala
390 395 400 405
tct agc agc atc ggc cac ggt gat gcg tat atg cag tcg gct tca gca 1363
Ser Ser Ser Ile Gly His Gly Asp Ala Tyr Met Gln Ser Ala Ser Ala
410 415 420
tcc gtg gaa aca atc gcg tca cat gca atc aat caa att gct acg caa 1411
Ser Val Glu Thr Ile Ala Ser His Ala Ile Asn Gln Ile Ala Thr Gln
425 430 435
gcc ggc atc cct gac ctc act gac cga att gtg gtc aaa cgc acc att 1459
Ala Gly Ile Pro Asp Leu Thr Asp Arg Ile Val Val Lys Arg Thr Ile
440 445 450
ggc cct gcg gat ttt gag cac cgc tac cat tca tgg gta ggc agt gcg 1507
Gly Pro Ala Asp Phe Glu His Arg Tyr His Ser Trp Val Gly Ser Ala
455 460 465
ctg ggt cca gca cat acc ctc aga cag tcc gct ttc tta aga ggg cgc 1555
Leu Gly Pro Ala His Thr Leu Arg Gln Ser Ala Phe Leu Arg Gly Arg
470 475 480 485
aat agc tcc cgc aag gtc aat aac ctc ttc tat tcc ggt gcc acc acc 1603
Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr Ser Gly Ala Thr Thr
490 495 500
gtc ccg ggt gta gga ata ccc atg tgt tta att tct gcc gag aat att 1651
Val Pro Gly Val Gly Ile Pro Met Cys Leu Ile Ser Ala Glu Asn Ile
505 510 515
att aag cgt tta cat gcc gat acc agt gca gga cca ctg ccc gaa cca 1699
Ile Lys Arg Leu His Ala Asp Thr Ser Ala Gly Pro Leu Pro Glu Pro
520 525 530
ttg ccg cct aaa acg aca cca tct caa aag acc tca tac gat cat 1744
Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr Ser Tyr Asp His
535 540 545
taaattttga tccctatcat cga 1767
<210> 262
<211> 548
<212> PRT
<213> Corynebacterium glutamicum
<400> 262
Met Lys Val Ser Thr Lys Thr Pro Arg Ser Ser Gly Thr Ala Val Val
1 5 10 15
Ile Gly Ala Gly Val Ala Gly Leu Ala Thr Ser Ala Leu Leu Ala Arg
20 25 30
Asp Gly Trp Gln Val Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly
35 40 45
Arg Ala Gly Ser Leu Glu Ile Ser Gly Phe Pro Gly Phe Arg Trp Asp
50 55 60
Thr Gly Pro Ser Trp Tyr Leu Met Pro Glu Ala Phe Asp His Phe Phe
65 70 75 80
Ala Leu Phe Gly Ala Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu
85 90 95
Thr Pro Gly Tyr Arg Val Phe Ser Gly Thr His Asp Ala Val Asp Val
100 105 110
Pro Thr Gly Arg Glu Glu Ala Ile Ala Leu Phe Glu Ser Ile Glu Pro
115 120 125
Gly Ala Gly Ala Lys Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala
130 135 140
Tyr Asp Ile Ala Ile Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu
145 150 155 160
Gly Pro Leu Leu His Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe
165 170 175
Ser Leu Leu Thr Arg Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser
180 185 190
Ser Pro Val Leu Arg Gln Ile Leu Thr Tyr Pro Ala Val Phe Leu Ser
195 200 205
Ser Arg Pro Thr Thr Thr Pro Ser Met Tyr His Leu Met Ser His Thr
210 215 220
Asp Leu Val Gln Gly Val Lys Tyr Pro Ile Gly Gly Phe Thr Ala Val
225 230 235 240
Val Asn Ala Leu His Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln
245 250 255
Leu Asp Ser Glu Val Ile Ser Ile Asn Thr Ala Ser Ser Arg Gly Asn
260 265 270
Thr Ser Ala Thr Gly Val Ser Leu Leu His Asn Arg Lys Val Gln Asn
275 280 285
Leu Asp Ala Asp Leu Val Val Ser Ala Gly Asp Leu His His Thr Glu
290 295 300
Asn Asn Leu Leu Pro Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp
305 310 315 320
Ser Asn Arg Asn Pro Gly Ile Gly Ala Val Leu Ile Leu Leu Gly Val
325 330 335
Lys Gly Glu Leu Pro Gln Leu Asp His His Asn Leu Phe Phe Ser Glu
340 345 350
Asp Trp Thr Asp Asp Phe Ala Val Val Phe Asp Gly Pro Gln Leu Thr
355 360 365
Arg Pro His Asn Ala Ser Asn Ser Ile Tyr Val Ser Lys Pro Ser Thr
370 375 380
Ser Glu Asp Gly Val Ala Pro Ala Gly Tyr Glu Asn Leu Phe Val Leu
385 390 395 400
Ile Pro Thr Lys Ala Ser Ser Ser Ile Gly His Gly Asp Ala Tyr Met
405 410 415
Gln Ser Ala Ser Ala Ser Val Glu Thr Ile Ala Ser His Ala Ile Asn
420 425 430
Gln Ile Ala Thr Gln Ala Gly Ile Pro Asp Leu Thr Asp Arg Ile Val
435 440 445
Val Lys Arg Thr Ile Gly Pro Ala Asp Phe Glu His Arg Tyr His Ser
450 455 460
Trp Val Gly Ser Ala Leu Gly Pro Ala His Thr Leu Arg Gln Ser Ala
465 470 475 480
Phe Leu Arg Gly Arg Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr
485 490 495
Ser Gly Ala Thr Thr Val Pro Gly Val Gly Ile Pro Met Cys Leu Ile
500 505 510
Ser Ala Glu Asn Ile Ile Lys Arg Leu His Ala Asp Thr Ser Ala Gly
515 520 525
Pro Leu Pro Glu Pro Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr
530 535 540
Ser Tyr Asp His
545
<210> 263
<211> 1767
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1744)
<223> FRXA00477
<400> 263
tgcgggagcg aatcagagtt ccacttcata tcaaactctc tacactcgct agagccacga 60
tgaaaggtct atctatgagc atctacagaa agaattcgtg atg aag gtc tcg act 115
Met Lys Val Ser Thr
1 5
aaa act cca cgc tcc tca ggt acc gcc gta gtc ata ggc gca ggt gtt 163
Lys Thr Pro Arg Ser Ser Gly Thr Ala Val Val Ile Gly Ala Gly Val
10 15 20
gct ggt tta gcc act tct gca ctt tta gca cgt gat ggc tgg caa gta 211
Ala Gly Leu Ala Thr Ser Ala Leu Leu Ala Arg Asp Gly Trp Gln Val
25 30 35
act gtt ttg gaa aaa aat act gat gtc ggt ggc cga gct gga tcg ctt 259
Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly Arg Ala Gly Ser Leu
40 45 50
gaa ata tca ggc ttt cct ggc ttt cga tgg gat acc gga cct tct tgg 307
Glu Ile Ser Gly Phe Pro Gly Phe Arg Trp Asp Thr Gly Pro Ser Trp
55 60 65
tac ctc atg ccc gag gcc ttt gac cat ttc ttc gca ctt ttt ggt gca 355
Tyr Leu Met Pro Glu Ala Phe Asp His Phe Phe Ala Leu Phe Gly Ala
70 75 80 85
tgt act tct gat tat ctc gat ttg gta gaa tta acg cct ggt tat cga 403
Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu Thr Pro Gly Tyr Arg
90 95 100
gtt ttt tct ggc aca cat gac gct gtc gat gtc ccc act ggg cgt gaa 451
Val Phe Ser Gly Thr His Asp Ala Val Asp Val Pro Thr Gly Arg Glu
105 110 115
gaa gca att gcg cta ttc gaa tcc atc gaa ccc ggc gcg ggt gca aaa 499
Glu Ala Ile Ala Leu Phe Glu Ser Ile Glu Pro Gly Ala Gly Ala Lys
120 125 130
cta gga aat tat ctt gat agc gcg gca gac gcc tat gac att gcc att 547
Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala Tyr Asp Ile Ala Ile
135 140 145
gat aga ttc ctt tat aat aat ttc tcc acg tta ggc ccg ctg ctt cac 595
Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu Gly Pro Leu Leu His
150 155 160 165
cgg gat gta ctg acc cga gct ggc cga ctg ttt tct cta ctg acc cgt 643
Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe Ser Leu Leu Thr Arg
170 175 180
tct tta caa aag tac gta aat agt caa ttc agt agc ccg gtg ttg cgc 691
Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser Ser Pro Val Leu Arg
185 190 195
cag atc cta acc tat cca gca gtc ttc ctg tct tcc cga ccc act act 739
Gln Ile Leu Thr Tyr Pro Ala Val Phe Leu Ser Ser Arg Pro Thr Thr
200 205 210
acc cca tcg atg tac cac ttg atg agt cat acc gat ttg gtg cag gga 787
Thr Pro Ser Met Tyr His Leu Met Ser His Thr Asp Leu Val Gln Gly
215 220 225
gtg aaa tac cct ata ggt ggt ttt act gca gtg gtt aac gct ctg cat 835
Val Lys Tyr Pro Ile Gly Gly Phe Thr Ala Val Val Asn Ala Leu His
230 235 240 245
cag tta gcg ctg gaa aac ggg gtt gag ttt caa ctc gat tct gag gtc 883
Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln Leu Asp Ser Glu Val
250 255 260
att tcc atc aac act gct tca tcg agg ggc aac aca agc gcc aca ggt 931
Ile Ser Ile Asn Thr Ala Ser Ser Arg Gly Asn Thr Ser Ala Thr Gly
265 270 275
gtg agc ttg ctt cac aac aga aaa gtg caa aat cta gat gcg gat ctt 979
Val Ser Leu Leu His Asn Arg Lys Val Gln Asn Leu Asp Ala Asp Leu
280 285 290
gtg gtt tca gca ggc gac cta cac cat aca gaa aat aat ctg ctt ccc 1027
Val Val Ser Ala Gly Asp Leu His His Thr Glu Asn Asn Leu Leu Pro
295 300 305
cgg gaa ctt cga acc tat ccc gaa cga tat tgg tcc aat cgc aat cct 1075
Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp Ser Asn Arg Asn Pro
310 315 320 325
gga att gga gcg gta tta atc ctc ctg ggc gta aaa gga gag tta ccc 1123
Gly Ile Gly Ala Val Leu Ile Leu Leu Gly Val Lys Gly Glu Leu Pro
330 335 340
cag ctc gac cat cac aac ctt ttc ttc agt gaa gat tgg aca gat gat 1171
Gln Leu Asp His His Asn Leu Phe Phe Ser Glu Asp Trp Thr Asp Asp
345 350 355
ttt gct gta gtt ttc gac ggg cct caa ctt acc cgc ccc cac aat gca 1219
Phe Ala Val Val Phe Asp Gly Pro Gln Leu Thr Arg Pro His Asn Ala
360 365 370
tca aat tcc att tat gtc tcc aag cct tca acg tcc gaa gac ggc gtt 1267
Ser Asn Ser Ile Tyr Val Ser Lys Pro Ser Thr Ser Glu Asp Gly Val
375 380 385
gca cct gct gga tac gaa aac ctt ttt gtt tta att ccg acc aag gcc 1315
Ala Pro Ala Gly Tyr Glu Asn Leu Phe Val Leu Ile Pro Thr Lys Ala
390 395 400 405
tct agc agc atc ggc cac ggt gat gcg tat atg cag tcg gct tca gca 1363
Ser Ser Ser Ile Gly His Gly Asp Ala Tyr Met Gln Ser Ala Ser Ala
410 415 420
tcc gtg gaa aca atc gcg tca cat gca atc aat caa att gct acg caa 1411
Ser Val Glu Thr Ile Ala Ser His Ala Ile Asn Gln Ile Ala Thr Gln
425 430 435
gcc ggc atc cct gac ctc act gac cga att gtg gtc aaa cgc acc att 1459
Ala Gly Ile Pro Asp Leu Thr Asp Arg Ile Val Val Lys Arg Thr Ile
440 445 450
ggc cct gcg gat ttt gag cac cgc tac cat tca tgg gta ggc agt gcg 1507
Gly Pro Ala Asp Phe Glu His Arg Tyr His Ser Trp Val Gly Ser Ala
455 460 465
ctg ggt cca gca cat acc ctc aga cag tcc gct ttc tta aga ggg cgc 1555
Leu Gly Pro Ala His Thr Leu Arg Gln Ser Ala Phe Leu Arg Gly Arg
470 475 480 485
aat agc tcc cgc aag gtc aat aac ctc ttc tat tcc ggt gcc acc acc 1603
Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr Ser Gly Ala Thr Thr
490 495 500
gtc ccg ggt gta gga ata ccc atg tgt tta att tct gcc gag aat att 1651
Val Pro Gly Val Gly Ile Pro Met Cys Leu Ile Ser Ala Glu Asn Ile
505 510 515
att aag cgt tta cat gcc gat acc agt gca gga cca ctg ccc gaa cca 1699
Ile Lys Arg Leu His Ala Asp Thr Ser Ala Gly Pro Leu Pro Glu Pro
520 525 530
ttg ccg cct aaa acg aca cca tct caa aag acc tca tac gat cat 1744
Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr Ser Tyr Asp His
535 540 545
taaattttga tccctatcat cga 1767
<210> 264
<211> 548
<212> PRT
<213> Corynebacterium glutamicum
<400> 264
Met Lys Val Ser Thr Lys Thr Pro Arg Ser Ser Gly Thr Ala Val Val
1 5 10 15
Ile Gly Ala Gly Val Ala Gly Leu Ala Thr Ser Ala Leu Leu Ala Arg
20 25 30
Asp Gly Trp Gln Val Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly
35 40 45
Arg Ala Gly Ser Leu Glu Ile Ser Gly Phe Pro Gly Phe Arg Trp Asp
50 55 60
Thr Gly Pro Ser Trp Tyr Leu Met Pro Glu Ala Phe Asp His Phe Phe
65 70 75 80
Ala Leu Phe Gly Ala Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu
85 90 95
Thr Pro Gly Tyr Arg Val Phe Ser Gly Thr His Asp Ala Val Asp Val
100 105 110
Pro Thr Gly Arg Glu Glu Ala Ile Ala Leu Phe Glu Ser Ile Glu Pro
115 120 125
Gly Ala Gly Ala Lys Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala
130 135 140
Tyr Asp Ile Ala Ile Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu
145 150 155 160
Gly Pro Leu Leu His Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe
165 170 175
Ser Leu Leu Thr Arg Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser
180 185 190
Ser Pro Val Leu Arg Gln Ile Leu Thr Tyr Pro Ala Val Phe Leu Ser
195 200 205
Ser Arg Pro Thr Thr Thr Pro Ser Met Tyr His Leu Met Ser His Thr
210 215 220
Asp Leu Val Gln Gly Val Lys Tyr Pro Ile Gly Gly Phe Thr Ala Val
225 230 235 240
Val Asn Ala Leu His Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln
245 250 255
Leu Asp Ser Glu Val Ile Ser Ile Asn Thr Ala Ser Ser Arg Gly Asn
260 265 270
Thr Ser Ala Thr Gly Val Ser Leu Leu His Asn Arg Lys Val Gln Asn
275 280 285
Leu Asp Ala Asp Leu Val Val Ser Ala Gly Asp Leu His His Thr Glu
290 295 300
Asn Asn Leu Leu Pro Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp
305 310 315 320
Ser Asn Arg Asn Pro Gly Ile Gly Ala Val Leu Ile Leu Leu Gly Val
325 330 335
Lys Gly Glu Leu Pro Gln Leu Asp His His Asn Leu Phe Phe Ser Glu
340 345 350
Asp Trp Thr Asp Asp Phe Ala Val Val Phe Asp Gly Pro Gln Leu Thr
355 360 365
Arg Pro His Asn Ala Ser Asn Ser Ile Tyr Val Ser Lys Pro Ser Thr
370 375 380
Ser Glu Asp Gly Val Ala Pro Ala Gly Tyr Glu Asn Leu Phe Val Leu
385 390 395 400
Ile Pro Thr Lys Ala Ser Ser Ser Ile Gly His Gly Asp Ala Tyr Met
405 410 415
Gln Ser Ala Ser Ala Ser Val Glu Thr Ile Ala Ser His Ala Ile Asn
420 425 430
Gln Ile Ala Thr Gln Ala Gly Ile Pro Asp Leu Thr Asp Arg Ile Val
435 440 445
Val Lys Arg Thr Ile Gly Pro Ala Asp Phe Glu His Arg Tyr His Ser
450 455 460
Trp Val Gly Ser Ala Leu Gly Pro Ala His Thr Leu Arg Gln Ser Ala
465 470 475 480
Phe Leu Arg Gly Arg Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr
485 490 495
Ser Gly Ala Thr Thr Val Pro Gly Val Gly Ile Pro Met Cys Leu Ile
500 505 510
Ser Ala Glu Asn Ile Ile Lys Arg Leu His Ala Asp Thr Ser Ala Gly
515 520 525
Pro Leu Pro Glu Pro Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr
530 535 540
Ser Tyr Asp His
545
<210> 265
<211> 954
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(931)
<223> RXA00478
<400> 265
accagaagca gcctcagcta tgacacacca aaattcgcct ctcttcctta aaagtgcact 60
gagactttac aatcgggcct cattcaaggc ttcacataaa gtg atc gaa gaa tat 115
Val Ile Glu Glu Tyr
1 5
tcc acg agc ttc agt ctg tct acg tgg ttg cta tcc cca cgc ata cga 163
Ser Thr Ser Phe Ser Leu Ser Thr Trp Leu Leu Ser Pro Arg Ile Arg
10 15 20
aat gac ata cga aat ctc tat gca gta gtt cgt atc gcc gat gag att 211
Asn Asp Ile Arg Asn Leu Tyr Ala Val Val Arg Ile Ala Asp Glu Ile
25 30 35
gtc gac ggc act gca cat gcc gct ggt tgc tca act gcc aaa atc gaa 259
Val Asp Gly Thr Ala His Ala Ala Gly Cys Ser Thr Ala Lys Ile Glu
40 45 50
gag att ctc gat gcc tat gaa att gcg gtt ctt gca gca cca caa caa 307
Glu Ile Leu Asp Ala Tyr Glu Ile Ala Val Leu Ala Ala Pro Gln Gln
55 60 65
cgc ttc aac aca gat ctt gtt tta caa gct tat ggt gaa act gcc cga 355
Arg Phe Asn Thr Asp Leu Val Leu Gln Ala Tyr Gly Glu Thr Ala Arg
70 75 80 85
cgc tgt gat ttc gaa caa gag cat gta ata gcc ttc ttt gca tca atg 403
Arg Cys Asp Phe Glu Gln Glu His Val Ile Ala Phe Phe Ala Ser Met
90 95 100
cgt aag gac ctc aaa gct aat aca cac gac cca gat agc ttc aca acg 451
Arg Lys Asp Leu Lys Ala Asn Thr His Asp Pro Asp Ser Phe Thr Thr
105 110 115
tat gtc tat ggc tcc gcg gaa gtt ata ggc ctg ctt tgt ctc agc gtt 499
Tyr Val Tyr Gly Ser Ala Glu Val Ile Gly Leu Leu Cys Leu Ser Val
120 125 130
ttc aac caa ggt aga acg att agc aaa aaa cgg cta gag att atg caa 547
Phe Asn Gln Gly Arg Thr Ile Ser Lys Lys Arg Leu Glu Ile Met Gln
135 140 145
aac gga gcc cgc tca ttg gga gcg gca ttc cag aaa att aac ttt ctc 595
Asn Gly Ala Arg Ser Leu Gly Ala Ala Phe Gln Lys Ile Asn Phe Leu
150 155 160 165
cgt gac ttg gca gaa gat cag caa aat ttg ggc cga ttt tat ttc ccc 643
Arg Asp Leu Ala Glu Asp Gln Gln Asn Leu Gly Arg Phe Tyr Phe Pro
170 175 180
aaa acc agc caa gga act ctt act aaa gaa caa aaa gaa gat ctc atc 691
Lys Thr Ser Gln Gly Thr Leu Thr Lys Glu Gln Lys Glu Asp Leu Ile
185 190 195
gct gat atc cgt caa gac cta gca att gcc cac gat gca ttt cca gaa 739
Ala Asp Ile Arg Gln Asp Leu Ala Ile Ala His Asp Ala Phe Pro Glu
200 205 210
ata cca gtg cag gct cgc atc gga gtg atc tct gct tat ttg ctc ttt 787
Ile Pro Val Gln Ala Arg Ile Gly Val Ile Ser Ala Tyr Leu Leu Phe
215 220 225
caa aaa ctc act gac cga att gag gct act cct acc gcc gat tta ttg 835
Gln Lys Leu Thr Asp Arg Ile Glu Ala Thr Pro Thr Ala Asp Leu Leu
230 235 240 245
cgg gag cga atc aga gtt cca ctt cat atc aaa ctc tct aca ctc gct 883
Arg Glu Arg Ile Arg Val Pro Leu His Ile Lys Leu Ser Thr Leu Ala
250 255 260
aga gcc acg atg aaa ggt cta tct atg agc atc tac aga aag aat tcg 931
Arg Ala Thr Met Lys Gly Leu Ser Met Ser Ile Tyr Arg Lys Asn Ser
265 270 275
tgatgaaggt ctcgactaaa act 954
<210> 266
<211> 277
<212> PRT
<213> Corynebacterium glutamicum
<400> 266
Val Ile Glu Glu Tyr Ser Thr Ser Phe Ser Leu Ser Thr Trp Leu Leu
1 5 10 15
Ser Pro Arg Ile Arg Asn Asp Ile Arg Asn Leu Tyr Ala Val Val Arg
20 25 30
Ile Ala Asp Glu Ile Val Asp Gly Thr Ala His Ala Ala Gly Cys Ser
35 40 45
Thr Ala Lys Ile Glu Glu Ile Leu Asp Ala Tyr Glu Ile Ala Val Leu
50 55 60
Ala Ala Pro Gln Gln Arg Phe Asn Thr Asp Leu Val Leu Gln Ala Tyr
65 70 75 80
Gly Glu Thr Ala Arg Arg Cys Asp Phe Glu Gln Glu His Val Ile Ala
85 90 95
Phe Phe Ala Ser Met Arg Lys Asp Leu Lys Ala Asn Thr His Asp Pro
100 105 110
Asp Ser Phe Thr Thr Tyr Val Tyr Gly Ser Ala Glu Val Ile Gly Leu
115 120 125
Leu Cys Leu Ser Val Phe Asn Gln Gly Arg Thr Ile Ser Lys Lys Arg
130 135 140
Leu Glu Ile Met Gln Asn Gly Ala Arg Ser Leu Gly Ala Ala Phe Gln
145 150 155 160
Lys Ile Asn Phe Leu Arg Asp Leu Ala Glu Asp Gln Gln Asn Leu Gly
165 170 175
Arg Phe Tyr Phe Pro Lys Thr Ser Gln Gly Thr Leu Thr Lys Glu Gln
180 185 190
Lys Glu Asp Leu Ile Ala Asp Ile Arg Gln Asp Leu Ala Ile Ala His
195 200 205
Asp Ala Phe Pro Glu Ile Pro Val Gln Ala Arg Ile Gly Val Ile Ser
210 215 220
Ala Tyr Leu Leu Phe Gln Lys Leu Thr Asp Arg Ile Glu Ala Thr Pro
225 230 235 240
Thr Ala Asp Leu Leu Arg Glu Arg Ile Arg Val Pro Leu His Ile Lys
245 250 255
Leu Ser Thr Leu Ala Arg Ala Thr Met Lys Gly Leu Ser Met Ser Ile
260 265 270
Tyr Arg Lys Asn Ser
275
<210> 267
<211> 1056
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1033)
<223> RXA01291
<400> 267
aacccgcagc gggtggagcg gggctgaggg agacgtcgag aagcgtccct ttcggttgtc 60
tggatttctc gcggtaaagt ttcctgtgaa ggaggcgagt gtg gct gat cag caa 115
Val Ala Asp Gln Gln
1 5
gat ttt ttg ggc cgt ttt gat gcg atg agc tca aag gcg acg gcc acg 163
Asp Phe Leu Gly Arg Phe Asp Ala Met Ser Ser Lys Ala Thr Ala Thr
10 15 20
gta atc gcc cat tat tcc tcc agt ttt act ctg gca tcg aag ctg ttg 211
Val Ile Ala His Tyr Ser Ser Ser Phe Thr Leu Ala Ser Lys Leu Leu
25 30 35
tcg ccg aaa att cgt cgc gat att gag gca ttg tac gca atg gtg cga 259
Ser Pro Lys Ile Arg Arg Asp Ile Glu Ala Leu Tyr Ala Met Val Arg
40 45 50
gtg gcc gat gag gtt gtg gac ggc gct gct gct gcc gcg ggg tgt gcg 307
Val Ala Asp Glu Val Val Asp Gly Ala Ala Ala Ala Ala Gly Cys Ala
55 60 65
ccg gac gcc gtt gcg gag att ttg gac aat tac gaa cgc cag gtt ctg 355
Pro Asp Ala Val Ala Glu Ile Leu Asp Asn Tyr Glu Arg Gln Val Leu
70 75 80 85
ctc agt ttg tcc gtt cct ttt cat acc gat cca gtg atc cat gcg ttt 403
Leu Ser Leu Ser Val Pro Phe His Thr Asp Pro Val Ile His Ala Phe
90 95 100
ggc aat acc gcc cgc aaa tgt ggt ttt gag cag gct cac atc gtg gcg 451
Gly Asn Thr Ala Arg Lys Cys Gly Phe Glu Gln Ala His Ile Val Ala
105 110 115
ttt ttt gat tcc atg cgc cgc gat ctc tcc caa acc tcc tat gat ccg 499
Phe Phe Asp Ser Met Arg Arg Asp Leu Ser Gln Thr Ser Tyr Asp Pro
120 125 130
act cag ttg gat gag tac att tac ggc tcc gct gag gtc atc ggg ttg 547
Thr Gln Leu Asp Glu Tyr Ile Tyr Gly Ser Ala Glu Val Ile Gly Leu
135 140 145
atg tgt ttg aaa att ttc ctc caa gat tcc act gcc agc ccg cag gat 595
Met Cys Leu Lys Ile Phe Leu Gln Asp Ser Thr Ala Ser Pro Gln Asp
150 155 160 165
cgg gcc acg atg gaa cac ggc gcc agg cgt ttg ggt gcg gca ttt caa 643
Arg Ala Thr Met Glu His Gly Ala Arg Arg Leu Gly Ala Ala Phe Gln
170 175 180
aag gta aat ttc ctg cga gat cta gct gaa gac cgc gaa ggc cta ggc 691
Lys Val Asn Phe Leu Arg Asp Leu Ala Glu Asp Arg Glu Gly Leu Gly
185 190 195
cgt tct tat ttg ccg gta ttc acc gaa gaa atg cgc gat gag atc gtt 739
Arg Ser Tyr Leu Pro Val Phe Thr Glu Glu Met Arg Asp Glu Ile Val
200 205 210
act gat atc cga gag gat ttg gat gcc gcc cgg ctg agc att ccg ctg 787
Thr Asp Ile Arg Glu Asp Leu Asp Ala Ala Arg Leu Ser Ile Pro Leu
215 220 225
ctg cca ttt ggc gcg cga acc ggt gtg cgc gcc gcg acc gat ctc tac 835
Leu Pro Phe Gly Ala Arg Thr Gly Val Arg Ala Ala Thr Asp Leu Tyr
230 235 240 245
ggt tgc ctc gtg gac aac ctg gaa tcc gcg tcc ctc gaa gac tta aaa 883
Gly Cys Leu Val Asp Asn Leu Glu Ser Ala Ser Leu Glu Asp Leu Lys
250 255 260
aac ggg cgg gat ttt gtg ccg tct tta aaa aag cca gcc tgg caa cca 931
Asn Gly Arg Asp Phe Val Pro Ser Leu Lys Lys Pro Ala Trp Gln Pro
265 270 275
aag caa tgt gga aag aag tgt ttc aaa aat gac aaa agc agt ggt cat 979
Lys Gln Cys Gly Lys Lys Cys Phe Lys Asn Asp Lys Ser Ser Gly His
280 285 290
cgg cgg ggg act agc agg act agc cac cac cgc act gct ctt acg cga 1027
Arg Arg Gly Thr Ser Arg Thr Ser His His Arg Thr Ala Leu Thr Arg
295 300 305
agg ata tgaagtccac ctcgtcgaac aaa 1056
Arg Ile
310
<210> 268
<211> 311
<212> PRT
<213> Corynebacterium glutamicum
<400> 268
Val Ala Asp Gln Gln Asp Phe Leu Gly Arg Phe Asp Ala Met Ser Ser
1 5 10 15
Lys Ala Thr Ala Thr Val Ile Ala His Tyr Ser Ser Ser Phe Thr Leu
20 25 30
Ala Ser Lys Leu Leu Ser Pro Lys Ile Arg Arg Asp Ile Glu Ala Leu
35 40 45
Tyr Ala Met Val Arg Val Ala Asp Glu Val Val Asp Gly Ala Ala Ala
50 55 60
Ala Ala Gly Cys Ala Pro Asp Ala Val Ala Glu Ile Leu Asp Asn Tyr
65 70 75 80
Glu Arg Gln Val Leu Leu Ser Leu Ser Val Pro Phe His Thr Asp Pro
85 90 95
Val Ile His Ala Phe Gly Asn Thr Ala Arg Lys Cys Gly Phe Glu Gln
100 105 110
Ala His Ile Val Ala Phe Phe Asp Ser Met Arg Arg Asp Leu Ser Gln
115 120 125
Thr Ser Tyr Asp Pro Thr Gln Leu Asp Glu Tyr Ile Tyr Gly Ser Ala
130 135 140
Glu Val Ile Gly Leu Met Cys Leu Lys Ile Phe Leu Gln Asp Ser Thr
145 150 155 160
Ala Ser Pro Gln Asp Arg Ala Thr Met Glu His Gly Ala Arg Arg Leu
165 170 175
Gly Ala Ala Phe Gln Lys Val Asn Phe Leu Arg Asp Leu Ala Glu Asp
180 185 190
Arg Glu Gly Leu Gly Arg Ser Tyr Leu Pro Val Phe Thr Glu Glu Met
195 200 205
Arg Asp Glu Ile Val Thr Asp Ile Arg Glu Asp Leu Asp Ala Ala Arg
210 215 220
Leu Ser Ile Pro Leu Leu Pro Phe Gly Ala Arg Thr Gly Val Arg Ala
225 230 235 240
Ala Thr Asp Leu Tyr Gly Cys Leu Val Asp Asn Leu Glu Ser Ala Ser
245 250 255
Leu Glu Asp Leu Lys Asn Gly Arg Asp Phe Val Pro Ser Leu Lys Lys
260 265 270
Pro Ala Trp Gln Pro Lys Gln Cys Gly Lys Lys Cys Phe Lys Asn Asp
275 280 285
Lys Ser Ser Gly His Arg Arg Gly Thr Ser Arg Thr Ser His His Arg
290 295 300
Thr Ala Leu Thr Arg Arg Ile
305 310
<210> 269
<211> 1239
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1216)
<223> RXA00480
<400> 269
tttatggacc caaattcaca ctttctgtac ttcatcaaaa taaagcgcca tatacaacga 60
ttgggaattt ttgcgagata actggccgtg tgatactcga atg gac aat ggc atg 115
Met Asp Asn Gly Met
1 5
aca atc acc aca gaa cat tca act cat cct gat ctt gat ttc aat gat 163
Thr Ile Thr Thr Glu His Ser Thr His Pro Asp Leu Asp Phe Asn Asp
10 15 20
gag att tat cgg gaa cta aac cgc atc tgc gct tcg cta tct caa cag 211
Glu Ile Tyr Arg Glu Leu Asn Arg Ile Cys Ala Ser Leu Ser Gln Gln
25 30 35
tgc agc aca tat caa cca gag ttc cgt acc tgc cta gat gct gct ttc 259
Cys Ser Thr Tyr Gln Pro Glu Phe Arg Thr Cys Leu Asp Ala Ala Phe
40 45 50
caa gct ttg cga ggt ggc aag tta atc cgc cct cga atg cta ctg ggg 307
Gln Ala Leu Arg Gly Gly Lys Leu Ile Arg Pro Arg Met Leu Leu Gly
55 60 65
cta tac aac acg ctt gta gac gat gac att gag gtc aaa ctc aac acc 355
Leu Tyr Asn Thr Leu Val Asp Asp Asp Ile Glu Val Lys Leu Asn Thr
70 75 80 85
gtt tta cag gta gca gtg gct tta gaa cta ctg cat ttt tcc ctt ttg 403
Val Leu Gln Val Ala Val Ala Leu Glu Leu Leu His Phe Ser Leu Leu
90 95 100
gtt cat gac gat gtt att gac gga gac ctc tat cgc cga ggc aaa ctt 451
Val His Asp Asp Val Ile Asp Gly Asp Leu Tyr Arg Arg Gly Lys Leu
105 110 115
aat ttt att ggg cag att ctc atg cat cgc aca cct gaa agt ttt gca 499
Asn Phe Ile Gly Gln Ile Leu Met His Arg Thr Pro Glu Ser Phe Ala
120 125 130
caa atc cag cgc gat cca gag cat cta gat tgg gca caa tct aat gga 547
Gln Ile Gln Arg Asp Pro Glu His Leu Asp Trp Ala Gln Ser Asn Gly
135 140 145
ctg ctt atg gga aat ctt ttt ctt gct gcc acc cat caa atc ttc gcg 595
Leu Leu Met Gly Asn Leu Phe Leu Ala Ala Thr His Gln Ile Phe Ala
150 155 160 165
cgc ctt gac ctt cca cat cac caa cgg gtt cga ctt tta gat tta ctc 643
Arg Leu Asp Leu Pro His His Gln Arg Val Arg Leu Leu Asp Leu Leu
170 175 180
aac cac acg ata aat gac act att gtg ggt gag ttt ctt gat gtg gga 691
Asn His Thr Ile Asn Asp Thr Ile Val Gly Glu Phe Leu Asp Val Gly
185 190 195
tta agc agc aaa gcc atc agc ccc aat atg gac att gct cta gaa atg 739
Leu Ser Ser Lys Ala Ile Ser Pro Asn Met Asp Ile Ala Leu Glu Met
200 205 210
agt cgg cta aaa aca gcc aca tac act ttt gaa ctt cca atg aga gca 787
Ser Arg Leu Lys Thr Ala Thr Tyr Thr Phe Glu Leu Pro Met Arg Ala
215 220 225
gcg gca att ctc gcg gaa cta cct cag gag att gaa aca aag ata ggt 835
Ala Ala Ile Leu Ala Glu Leu Pro Gln Glu Ile Glu Thr Lys Ile Gly
230 235 240 245
gag ata ggc aca aac ttg ggc atc gct tat caa ttg cag gac gat tac 883
Glu Ile Gly Thr Asn Leu Gly Ile Ala Tyr Gln Leu Gln Asp Asp Tyr
250 255 260
tta tct act ttt ggt gac gca gcc gaa cac ggc aaa gat gcc ttt tct 931
Leu Ser Thr Phe Gly Asp Ala Ala Glu His Gly Lys Asp Ala Phe Ser
265 270 275
gac ctt cga gaa gga aaa gaa act aca att atc gcc ttc gct cga gat 979
Asp Leu Arg Glu Gly Lys Glu Thr Thr Ile Ile Ala Phe Ala Arg Asp
280 285 290
act gct aaa tgg act gat att caa gac aac ttc ggc tcc gca gat ctg 1027
Thr Ala Lys Trp Thr Asp Ile Gln Asp Asn Phe Gly Ser Ala Asp Leu
295 300 305
agc acc tct cag gca gag cga att caa cat ctt ctc ata cag tgt gga 1075
Ser Thr Ser Gln Ala Glu Arg Ile Gln His Leu Leu Ile Gln Cys Gly
310 315 320 325
gca aag aat cac tcc ttg aat gcc atc tcc gac cac tta aat atc tgc 1123
Ala Lys Asn His Ser Leu Asn Ala Ile Ser Asp His Leu Asn Ile Cys
330 335 340
cgt tcg atg atc aaa aca cta agc ccc cag gta gat ccc aag gct caa 1171
Arg Ser Met Ile Lys Thr Leu Ser Pro Gln Val Asp Pro Lys Ala Gln
345 350 355
aat tta tta ctt aaa caa gtt gag caa cta gcc agc cgc aaa tct 1216
Asn Leu Leu Leu Lys Gln Val Glu Gln Leu Ala Ser Arg Lys Ser
360 365 370
tagaactaac ctttacgcct tta 1239
<210> 270
<211> 372
<212> PRT
<213> Corynebacterium glutamicum
<400> 270
Met Asp Asn Gly Met Thr Ile Thr Thr Glu His Ser Thr His Pro Asp
1 5 10 15
Leu Asp Phe Asn Asp Glu Ile Tyr Arg Glu Leu Asn Arg Ile Cys Ala
20 25 30
Ser Leu Ser Gln Gln Cys Ser Thr Tyr Gln Pro Glu Phe Arg Thr Cys
35 40 45
Leu Asp Ala Ala Phe Gln Ala Leu Arg Gly Gly Lys Leu Ile Arg Pro
50 55 60
Arg Met Leu Leu Gly Leu Tyr Asn Thr Leu Val Asp Asp Asp Ile Glu
65 70 75 80
Val Lys Leu Asn Thr Val Leu Gln Val Ala Val Ala Leu Glu Leu Leu
85 90 95
His Phe Ser Leu Leu Val His Asp Asp Val Ile Asp Gly Asp Leu Tyr
100 105 110
Arg Arg Gly Lys Leu Asn Phe Ile Gly Gln Ile Leu Met His Arg Thr
115 120 125
Pro Glu Ser Phe Ala Gln Ile Gln Arg Asp Pro Glu His Leu Asp Trp
130 135 140
Ala Gln Ser Asn Gly Leu Leu Met Gly Asn Leu Phe Leu Ala Ala Thr
145 150 155 160
His Gln Ile Phe Ala Arg Leu Asp Leu Pro His His Gln Arg Val Arg
165 170 175
Leu Leu Asp Leu Leu Asn His Thr Ile Asn Asp Thr Ile Val Gly Glu
180 185 190
Phe Leu Asp Val Gly Leu Ser Ser Lys Ala Ile Ser Pro Asn Met Asp
195 200 205
Ile Ala Leu Glu Met Ser Arg Leu Lys Thr Ala Thr Tyr Thr Phe Glu
210 215 220
Leu Pro Met Arg Ala Ala Ala Ile Leu Ala Glu Leu Pro Gln Glu Ile
225 230 235 240
Glu Thr Lys Ile Gly Glu Ile Gly Thr Asn Leu Gly Ile Ala Tyr Gln
245 250 255
Leu Gln Asp Asp Tyr Leu Ser Thr Phe Gly Asp Ala Ala Glu His Gly
260 265 270
Lys Asp Ala Phe Ser Asp Leu Arg Glu Gly Lys Glu Thr Thr Ile Ile
275 280 285
Ala Phe Ala Arg Asp Thr Ala Lys Trp Thr Asp Ile Gln Asp Asn Phe
290 295 300
Gly Ser Ala Asp Leu Ser Thr Ser Gln Ala Glu Arg Ile Gln His Leu
305 310 315 320
Leu Ile Gln Cys Gly Ala Lys Asn His Ser Leu Asn Ala Ile Ser Asp
325 330 335
His Leu Asn Ile Cys Arg Ser Met Ile Lys Thr Leu Ser Pro Gln Val
340 345 350
Asp Pro Lys Ala Gln Asn Leu Leu Leu Lys Gln Val Glu Gln Leu Ala
355 360 365
Ser Arg Lys Ser
370
<210> 271
<211> 1056
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1033)
<223> RXS01879
<400> 271
ctttgcgggc cgctgatatt gatccaacgc ttcgtggcga aaagcttgat gtcactgact 60
atgtgcgcct agctggggtg ttgcagcaaa aggatgagaa gtg aaa att acc gct 115
Val Lys Ile Thr Ala
1 5
aag gcg tgg gcg aaa acc aac ctg cat tta ggt gtg gga ccg gct cac 163
Lys Ala Trp Ala Lys Thr Asn Leu His Leu Gly Val Gly Pro Ala His
10 15 20
gac gat gga ttt cac gag ctc atg acg gtg ttt caa acc att gat ctg 211
Asp Asp Gly Phe His Glu Leu Met Thr Val Phe Gln Thr Ile Asp Leu
25 30 35
ttt gac acc gtc acc tta acc acc ctc gat gag gag ttg gtg gag gag 259
Phe Asp Thr Val Thr Leu Thr Thr Leu Asp Glu Glu Leu Val Glu Glu
40 45 50
ggg agc gtc gtc aag caa tta tct gtg acc ggt gcc cgt ggc gtg cct 307
Gly Ser Val Val Lys Gln Leu Ser Val Thr Gly Ala Arg Gly Val Pro
55 60 65
gag gac gcc agc aat ctt gcg tgg cgc gct gtg gat gcg ttg gtt aag 355
Glu Asp Ala Ser Asn Leu Ala Trp Arg Ala Val Asp Ala Leu Val Lys
70 75 80 85
cgg cgc gcg gaa aag acg ccg ctg tct gca gtt tcg ctg cat att tcc 403
Arg Arg Ala Glu Lys Thr Pro Leu Ser Ala Val Ser Leu His Ile Ser
90 95 100
aag ggg att ccg gtg gct ggc ggc atg gct ggc ggc tct gcg gat gcg 451
Lys Gly Ile Pro Val Ala Gly Gly Met Ala Gly Gly Ser Ala Asp Ala
105 110 115
gct gcg aca ctg cgc gca gtg gat gcc tgg att ggg cct ttc ggc gag 499
Ala Ala Thr Leu Arg Ala Val Asp Ala Trp Ile Gly Pro Phe Gly Glu
120 125 130
gac aca ttg ctg gag gtt gcc gcg gag ctc ggc tca gat gtg ccg ttt 547
Asp Thr Leu Leu Glu Val Ala Ala Glu Leu Gly Ser Asp Val Pro Phe
135 140 145
tgc ctg ctt ggt ggc acc atg cgc ggt acc ggt cgc ggc gag cag ctg 595
Cys Leu Leu Gly Gly Thr Met Arg Gly Thr Gly Arg Gly Glu Gln Leu
150 155 160 165
gta gat atg ttg acg cgc ggc aag cta cat tgg gtg gtg gcc gcg atg 643
Val Asp Met Leu Thr Arg Gly Lys Leu His Trp Val Val Ala Ala Met
170 175 180
gcg cat ggc ctg tcc acg cct gag gta ttc aaa aag cat gat gag ctg 691
Ala His Gly Leu Ser Thr Pro Glu Val Phe Lys Lys His Asp Glu Leu
185 190 195
aat ccg gaa tcg cat atg gat atc agc gac ctc agc gcc gca ctt ctc 739
Asn Pro Glu Ser His Met Asp Ile Ser Asp Leu Ser Ala Ala Leu Leu
200 205 210
acc ggc aac acc gcc gag gtg ggg cag tgg ctg cac aat gat ctg acc 787
Thr Gly Asn Thr Ala Glu Val Gly Gln Trp Leu His Asn Asp Leu Thr
215 220 225
agc gcc gca ctc agt ttg cgc cct gaa ctg cgc agc gtc ctc caa gaa 835
Ser Ala Ala Leu Ser Leu Arg Pro Glu Leu Arg Ser Val Leu Gln Glu
230 235 240 245
ggc atc cgc tcc ggc gcg cat gca gga att gtc tcc ggc tcc ggc ccg 883
Gly Ile Arg Ser Gly Ala His Ala Gly Ile Val Ser Gly Ser Gly Pro
250 255 260
acc acg gta ttc ttg tgc gaa tcg gag cac aaa gcg caa gac gtt aaa 931
Thr Thr Val Phe Leu Cys Glu Ser Glu His Lys Ala Gln Asp Val Lys
265 270 275
gag gcg cta atc gac gcc ggc cag gtg tac gct gct tac acc gcc acc 979
Glu Ala Leu Ile Asp Ala Gly Gln Val Tyr Ala Ala Tyr Thr Ala Thr
280 285 290
ggc cct gcg gcc tca acc gcc gac cag cgc ggc gca cac att ttg act 1027
Gly Pro Ala Ala Ser Thr Ala Asp Gln Arg Gly Ala His Ile Leu Thr
295 300 305
gtt tca taataaagac aaacttaagt atc 1056
Val Ser
310
<210> 272
<211> 311
<212> PRT
<213> Corynebacterium glutamicum
<400> 272
Val Lys Ile Thr Ala Lys Ala Trp Ala Lys Thr Asn Leu His Leu Gly
1 5 10 15
Val Gly Pro Ala His Asp Asp Gly Phe His Glu Leu Met Thr Val Phe
20 25 30
Gln Thr Ile Asp Leu Phe Asp Thr Val Thr Leu Thr Thr Leu Asp Glu
35 40 45
Glu Leu Val Glu Glu Gly Ser Val Val Lys Gln Leu Ser Val Thr Gly
50 55 60
Ala Arg Gly Val Pro Glu Asp Ala Ser Asn Leu Ala Trp Arg Ala Val
65 70 75 80
Asp Ala Leu Val Lys Arg Arg Ala Glu Lys Thr Pro Leu Ser Ala Val
85 90 95
Ser Leu His Ile Ser Lys Gly Ile Pro Val Ala Gly Gly Met Ala Gly
100 105 110
Gly Ser Ala Asp Ala Ala Ala Thr Leu Arg Ala Val Asp Ala Trp Ile
115 120 125
Gly Pro Phe Gly Glu Asp Thr Leu Leu Glu Val Ala Ala Glu Leu Gly
130 135 140
Ser Asp Val Pro Phe Cys Leu Leu Gly Gly Thr Met Arg Gly Thr Gly
145 150 155 160
Arg Gly Glu Gln Leu Val Asp Met Leu Thr Arg Gly Lys Leu His Trp
165 170 175
Val Val Ala Ala Met Ala His Gly Leu Ser Thr Pro Glu Val Phe Lys
180 185 190
Lys His Asp Glu Leu Asn Pro Glu Ser His Met Asp Ile Ser Asp Leu
195 200 205
Ser Ala Ala Leu Leu Thr Gly Asn Thr Ala Glu Val Gly Gln Trp Leu
210 215 220
His Asn Asp Leu Thr Ser Ala Ala Leu Ser Leu Arg Pro Glu Leu Arg
225 230 235 240
Ser Val Leu Gln Glu Gly Ile Arg Ser Gly Ala His Ala Gly Ile Val
245 250 255
Ser Gly Ser Gly Pro Thr Thr Val Phe Leu Cys Glu Ser Glu His Lys
260 265 270
Ala Gln Asp Val Lys Glu Ala Leu Ile Asp Ala Gly Gln Val Tyr Ala
275 280 285
Ala Tyr Thr Ala Thr Gly Pro Ala Ala Ser Thr Ala Asp Gln Arg Gly
290 295 300
Ala His Ile Leu Thr Val Ser
305 310
<210> 273
<211> 891
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(868)
<223> RXS02023
<400> 273
gatgtggcag caattttgaa gcagtacctg agcgagtaac cgcattcggg gttatcgtgg 60
gacttccgaa atgtaactag agactagagg aggaaacacg atg gct cct aaa caa 115
Met Ala Pro Lys Gln
1 5
act ccc agc cca gag aag aat cga aac ctg gtg gga cca gtt ctg caa 163
Thr Pro Ser Pro Glu Lys Asn Arg Asn Leu Val Gly Pro Val Leu Gln
10 15 20
cgt cgg cag aca gag ggt act ttt gat caa cgc ttg cta gaa atg cgc 211
Arg Arg Gln Thr Glu Gly Thr Phe Asp Gln Arg Leu Leu Glu Met Arg
25 30 35
gct gat cac aat tgg aag cac gcc gat cca tgg cgt gta ctg cgt att 259
Ala Asp His Asn Trp Lys His Ala Asp Pro Trp Arg Val Leu Arg Ile
40 45 50
cag tct gag ttt gtg gcg ggt ttt gat gcc ctc cac gag atg cca aag 307
Gln Ser Glu Phe Val Ala Gly Phe Asp Ala Leu His Glu Met Pro Lys
55 60 65
gcc gta acc gtc ttt ggt tcc gca cgc att aaa gag gat cac ccg tac 355
Ala Val Thr Val Phe Gly Ser Ala Arg Ile Lys Glu Asp His Pro Tyr
70 75 80 85
tac aag gcg ggt gta gaa ctt ggt gaa aag ctc gtt gca gcg gac tac 403
Tyr Lys Ala Gly Val Glu Leu Gly Glu Lys Leu Val Ala Ala Asp Tyr
90 95 100
gca gtt gtc acc ggt ggc ggt cca ggt ctg atg gaa gcc ccc aat aag 451
Ala Val Val Thr Gly Gly Gly Pro Gly Leu Met Glu Ala Pro Asn Lys
105 110 115
ggg gca agc gag gcc aat ggt tta tca gtt ggt ctg ggc att gag ttg 499
Gly Ala Ser Glu Ala Asn Gly Leu Ser Val Gly Leu Gly Ile Glu Leu
120 125 130
cca cat gaa cag cat ctg aac cct tat gtg gat ttg ggt ctg aac ttc 547
Pro His Glu Gln His Leu Asn Pro Tyr Val Asp Leu Gly Leu Asn Phe
135 140 145
cgg tac ttc ttc gca cgc aag acc atg ttc ctg aaa tac tcc cag gct 595
Arg Tyr Phe Phe Ala Arg Lys Thr Met Phe Leu Lys Tyr Ser Gln Ala
150 155 160 165
ttt gtg tgt ctg cct ggt ggt ttc ggc acg ctc gat gag ctt ttc gag 643
Phe Val Cys Leu Pro Gly Gly Phe Gly Thr Leu Asp Glu Leu Phe Glu
170 175 180
gtc ctc tgc atg gta caa acc ggc aag gta ccc aac ttt ccc atc gtg 691
Val Leu Cys Met Val Gln Thr Gly Lys Val Pro Asn Phe Pro Ile Val
185 190 195
ctg atc ggc act gag ttc tgg gca ggt ttg gtg gat tgg atc cgt cac 739
Leu Ile Gly Thr Glu Phe Trp Ala Gly Leu Val Asp Trp Ile Arg His
200 205 210
cgc ctg gta gag gaa ggc atg atc gat gag aag gat gtt gac cgg atg 787
Arg Leu Val Glu Glu Gly Met Ile Asp Glu Lys Asp Val Asp Arg Met
215 220 225
ttg gtc act gat gac ctg gat cag gcc gtc aaa ttc atc gtc gat gca 835
Leu Val Thr Asp Asp Leu Asp Gln Ala Val Lys Phe Ile Val Asp Ala
230 235 240 245
cac gct gga ttg gac gta gcg cgt ctc cac aat taagcagtgg ctacattagg 888
His Ala Gly Leu Asp Val Ala Arg Leu His Asn
250 255
tgt 891
<210> 274
<211> 256
<212> PRT
<213> Corynebacterium glutamicum
<400> 274
Met Ala Pro Lys Gln Thr Pro Ser Pro Glu Lys Asn Arg Asn Leu Val
1 5 10 15
Gly Pro Val Leu Gln Arg Arg Gln Thr Glu Gly Thr Phe Asp Gln Arg
20 25 30
Leu Leu Glu Met Arg Ala Asp His Asn Trp Lys His Ala Asp Pro Trp
35 40 45
Arg Val Leu Arg Ile Gln Ser Glu Phe Val Ala Gly Phe Asp Ala Leu
50 55 60
His Glu Met Pro Lys Ala Val Thr Val Phe Gly Ser Ala Arg Ile Lys
65 70 75 80
Glu Asp His Pro Tyr Tyr Lys Ala Gly Val Glu Leu Gly Glu Lys Leu
85 90 95
Val Ala Ala Asp Tyr Ala Val Val Thr Gly Gly Gly Pro Gly Leu Met
100 105 110
Glu Ala Pro Asn Lys Gly Ala Ser Glu Ala Asn Gly Leu Ser Val Gly
115 120 125
Leu Gly Ile Glu Leu Pro His Glu Gln His Leu Asn Pro Tyr Val Asp
130 135 140
Leu Gly Leu Asn Phe Arg Tyr Phe Phe Ala Arg Lys Thr Met Phe Leu
145 150 155 160
Lys Tyr Ser Gln Ala Phe Val Cys Leu Pro Gly Gly Phe Gly Thr Leu
165 170 175
Asp Glu Leu Phe Glu Val Leu Cys Met Val Gln Thr Gly Lys Val Pro
180 185 190
Asn Phe Pro Ile Val Leu Ile Gly Thr Glu Phe Trp Ala Gly Leu Val
195 200 205
Asp Trp Ile Arg His Arg Leu Val Glu Glu Gly Met Ile Asp Glu Lys
210 215 220
Asp Val Asp Arg Met Leu Val Thr Asp Asp Leu Asp Gln Ala Val Lys
225 230 235 240
Phe Ile Val Asp Ala His Ala Gly Leu Asp Val Ala Arg Leu His Asn
245 250 255
<210> 275
<211> 1242
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1219)
<223> RXS00948
<400> 275
acaccctcca aatgatctcg taaaacagta ttgaatttag gtacgactct aatcgtacct 60
tgccctcaag ccaagctagt tgtacgatca aactcgttgt atg gca aac gtc gta 115
Met Ala Asn Val Val
1 5
cta gtc gat cga atg gag cct ttg gtg tcc aag ctg ttt acc cca att 163
Leu Val Asp Arg Met Glu Pro Leu Val Ser Lys Leu Phe Thr Pro Ile
10 15 20
caa atc cgc gac atc acc atc ccc aac cgc gtg tgg atg tca ccg atg 211
Gln Ile Arg Asp Ile Thr Ile Pro Asn Arg Val Trp Met Ser Pro Met
25 30 35
tgc acc tac tct gca gcc acc ggt tca ggt ctt ccc acc gat ttt cac 259
Cys Thr Tyr Ser Ala Ala Thr Gly Ser Gly Leu Pro Thr Asp Phe His
40 45 50
cag gct cat tac gca gct cgc gca gca ggt ggt gtc gga tta gtc atg 307
Gln Ala His Tyr Ala Ala Arg Ala Ala Gly Gly Val Gly Leu Val Met
55 60 65
gtt gaa gca act gga gtg aac ccc gta gct ccc atc tcc cca gtc gac 355
Val Glu Ala Thr Gly Val Asn Pro Val Ala Pro Ile Ser Pro Val Asp
70 75 80 85
ctt gga ctt tgg agc cat gac caa att gaa cca ttc tcc cga gtg aca 403
Leu Gly Leu Trp Ser His Asp Gln Ile Glu Pro Phe Ser Arg Val Thr
90 95 100
gca gct att cgc gcc ggt ggg gca gta ccg gcc gtt caa tta gcc cat 451
Ala Ala Ile Arg Ala Gly Gly Ala Val Pro Ala Val Gln Leu Ala His
105 110 115
gct ggc cgc aag gca tcc acc gat gct ccg tgg aat ggt ggc gga tat 499
Ala Gly Arg Lys Ala Ser Thr Asp Ala Pro Trp Asn Gly Gly Gly Tyr
120 125 130
gtt gga cca gaa acc aat gga tgg gag act gtc ggc ccc agc cct ctg 547
Val Gly Pro Glu Thr Asn Gly Trp Glu Thr Val Gly Pro Ser Pro Leu
135 140 145
gca ttc cca ggt ttg cct gct ccg cgc gag ctg acg gtt tca gaa atc 595
Ala Phe Pro Gly Leu Pro Ala Pro Arg Glu Leu Thr Val Ser Glu Ile
150 155 160 165
caa gag gtt gtg cag cag ttc gct ggc gcc gcc gtt cgt gcc gat cag 643
Gln Glu Val Val Gln Gln Phe Ala Gly Ala Ala Val Arg Ala Asp Gln
170 175 180
gct ggt ttt gat gtc gtg gaa att cac gca gca cac ggc tac ctt ttg 691
Ala Gly Phe Asp Val Val Glu Ile His Ala Ala His Gly Tyr Leu Leu
185 190 195
cat aac ttc ctt tct ccg atc tcc aac aag cgc acc gat tca tac ggc 739
His Asn Phe Leu Ser Pro Ile Ser Asn Lys Arg Thr Asp Ser Tyr Gly
200 205 210
gga tct tta gaa aac cgc gct cgc atc gtg ctc gaa gtc att gat gca 787
Gly Ser Leu Glu Asn Arg Ala Arg Ile Val Leu Glu Val Ile Asp Ala
215 220 225
atc cgc gca gtg tgg cca gag gaa aag cct gta ttc atg cgc att tcc 835
Ile Arg Ala Val Trp Pro Glu Glu Lys Pro Val Phe Met Arg Ile Ser
230 235 240 245
acc acc gac tgg gtg gag gaa aac cca cag gat gat cgc gag tcc tgg 883
Thr Thr Asp Trp Val Glu Glu Asn Pro Gln Asp Asp Arg Glu Ser Trp
250 255 260
acg ctg agc caa agc agg cag ctg gct ttg tgg gca tcc gag cac gga 931
Thr Leu Ser Gln Ser Arg Gln Leu Ala Leu Trp Ala Ser Glu His Gly
265 270 275
gtt gat ttg atc gat gcc tct tct ggt ggc ctc gac atc gtc ccc att 979
Val Asp Leu Ile Asp Ala Ser Ser Gly Gly Leu Asp Ile Val Pro Ile
280 285 290
ccg cat gac cgc gat tac caa acc gcg aag gcc gca gat ctt cac gca 1027
Pro His Asp Arg Asp Tyr Gln Thr Ala Lys Ala Ala Asp Leu His Ala
295 300 305
agt acc gga gtg aca gtc gct gct gtg ggg cgc att gat gac gcc caa 1075
Ser Thr Gly Val Thr Val Ala Ala Val Gly Arg Ile Asp Asp Ala Gln
310 315 320 325
act gcg cac aat ttg gtt gat tct ggc gat gtc aat gca gtt ttc ctc 1123
Thr Ala His Asn Leu Val Asp Ser Gly Asp Val Asn Ala Val Phe Leu
330 335 340
ggc cgt cca ctg ctc aag gat cct tcc tgg gca aac caa gca gcc ctc 1171
Gly Arg Pro Leu Leu Lys Asp Pro Ser Trp Ala Asn Gln Ala Ala Leu
345 350 355
gca cta ggt gcg gaa ccc agg tat gtt cac caa tac gac tac gta ctt 1219
Ala Leu Gly Ala Glu Pro Arg Tyr Val His Gln Tyr Asp Tyr Val Leu
360 365 370
taaaggagag ttgacatgaa ggt 1242
<210> 276
<211> 373
<212> PRT
<213> Corynebacterium glutamicum
<400> 276
Met Ala Asn Val Val Leu Val Asp Arg Met Glu Pro Leu Val Ser Lys
1 5 10 15
Leu Phe Thr Pro Ile Gln Ile Arg Asp Ile Thr Ile Pro Asn Arg Val
20 25 30
Trp Met Ser Pro Met Cys Thr Tyr Ser Ala Ala Thr Gly Ser Gly Leu
35 40 45
Pro Thr Asp Phe His Gln Ala His Tyr Ala Ala Arg Ala Ala Gly Gly
50 55 60
Val Gly Leu Val Met Val Glu Ala Thr Gly Val Asn Pro Val Ala Pro
65 70 75 80
Ile Ser Pro Val Asp Leu Gly Leu Trp Ser His Asp Gln Ile Glu Pro
85 90 95
Phe Ser Arg Val Thr Ala Ala Ile Arg Ala Gly Gly Ala Val Pro Ala
100 105 110
Val Gln Leu Ala His Ala Gly Arg Lys Ala Ser Thr Asp Ala Pro Trp
115 120 125
Asn Gly Gly Gly Tyr Val Gly Pro Glu Thr Asn Gly Trp Glu Thr Val
130 135 140
Gly Pro Ser Pro Leu Ala Phe Pro Gly Leu Pro Ala Pro Arg Glu Leu
145 150 155 160
Thr Val Ser Glu Ile Gln Glu Val Val Gln Gln Phe Ala Gly Ala Ala
165 170 175
Val Arg Ala Asp Gln Ala Gly Phe Asp Val Val Glu Ile His Ala Ala
180 185 190
His Gly Tyr Leu Leu His Asn Phe Leu Ser Pro Ile Ser Asn Lys Arg
195 200 205
Thr Asp Ser Tyr Gly Gly Ser Leu Glu Asn Arg Ala Arg Ile Val Leu
210 215 220
Glu Val Ile Asp Ala Ile Arg Ala Val Trp Pro Glu Glu Lys Pro Val
225 230 235 240
Phe Met Arg Ile Ser Thr Thr Asp Trp Val Glu Glu Asn Pro Gln Asp
245 250 255
Asp Arg Glu Ser Trp Thr Leu Ser Gln Ser Arg Gln Leu Ala Leu Trp
260 265 270
Ala Ser Glu His Gly Val Asp Leu Ile Asp Ala Ser Ser Gly Gly Leu
275 280 285
Asp Ile Val Pro Ile Pro His Asp Arg Asp Tyr Gln Thr Ala Lys Ala
290 295 300
Ala Asp Leu His Ala Ser Thr Gly Val Thr Val Ala Ala Val Gly Arg
305 310 315 320
Ile Asp Asp Ala Gln Thr Ala His Asn Leu Val Asp Ser Gly Asp Val
325 330 335
Asn Ala Val Phe Leu Gly Arg Pro Leu Leu Lys Asp Pro Ser Trp Ala
340 345 350
Asn Gln Ala Ala Leu Ala Leu Gly Ala Glu Pro Arg Tyr Val His Gln
355 360 365
Tyr Asp Tyr Val Leu
370
<210> 277
<211> 1026
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1003)
<223> RXS02228
<400> 277
acagaagcgt caactgctca acttctcgac agcgacgaca cacacggcgt gggacgctac 60
gttgctcgct ggacttttta acttaaggga gatctagatc gtg gta aca ccg atc 115
Val Val Thr Pro Ile
1 5
gca gtg gtt gga ccc act gca tct gga aaa tca gct ttg gga att gct 163
Ala Val Val Gly Pro Thr Ala Ser Gly Lys Ser Ala Leu Gly Ile Ala
10 15 20
cta gcc cac aag ctt gac ggt gaa gta gtc aat gtg gat tcc atg cag 211
Leu Ala His Lys Leu Asp Gly Glu Val Val Asn Val Asp Ser Met Gln
25 30 35
ctg tac aaa ggc atg gac atc ggc acg gca aag ctg act gtc gaa gaa 259
Leu Tyr Lys Gly Met Asp Ile Gly Thr Ala Lys Leu Thr Val Glu Glu
40 45 50
cgc gaa ggc att gcg cat cat cag ctc gat gtc tgg gac gtt acc gaa 307
Arg Glu Gly Ile Ala His His Gln Leu Asp Val Trp Asp Val Thr Glu
55 60 65
act gcg tca gtg gcg agg ttt caa tcc gac gcc gtt gcc gat gtg gaa 355
Thr Ala Ser Val Ala Arg Phe Gln Ser Asp Ala Val Ala Asp Val Glu
70 75 80 85
gat att atg tcc cgt ggc aaa acc ccc atc ttg gtt ggc ggc tcc atg 403
Asp Ile Met Ser Arg Gly Lys Thr Pro Ile Leu Val Gly Gly Ser Met
90 95 100
ttg tac gtc caa tct ttg gtc gat gat tgg caa ttc cca cct acc gac 451
Leu Tyr Val Gln Ser Leu Val Asp Asp Trp Gln Phe Pro Pro Thr Asp
105 110 115
agc gct gtt cgc gca cgc ttt gag gcc cgc ttg gca gac atc ggt gtc 499
Ser Ala Val Arg Ala Arg Phe Glu Ala Arg Leu Ala Asp Ile Gly Val
120 125 130
gaa gca cta cac gct gaa ctt act cag ctt gac cca gaa gca gca gcc 547
Glu Ala Leu His Ala Glu Leu Thr Gln Leu Asp Pro Glu Ala Ala Ala
135 140 145
gtc atc gaa agc aat gat ccc cga cgc acc gtc cga gca tta gaa gtc 595
Val Ile Glu Ser Asn Asp Pro Arg Arg Thr Val Arg Ala Leu Glu Val
150 155 160 165
att gaa cta acc ggc cag ccc ttc caa gca agc caa ccg ccc aaa gac 643
Ile Glu Leu Thr Gly Gln Pro Phe Gln Ala Ser Gln Pro Pro Lys Asp
170 175 180
gcg cca cct cgc tgg gga act cga atc att ggc ctg aaa acc act cca 691
Ala Pro Pro Arg Trp Gly Thr Arg Ile Ile Gly Leu Lys Thr Thr Pro
185 190 195
gaa tgg cta aat cca cgc atc gag cag cgc acc gcc agg atg ttt gaa 739
Glu Trp Leu Asn Pro Arg Ile Glu Gln Arg Thr Ala Arg Met Phe Glu
200 205 210
caa ggc ttt gtc gcc gaa gtg gaa cac ctt gtg cag caa gga ctc atc 787
Gln Gly Phe Val Ala Glu Val Glu His Leu Val Gln Gln Gly Leu Ile
215 220 225
gct gac tcc acc gcg gga cga gca atc ggc tac tcc caa gta ctg gca 835
Ala Asp Ser Thr Ala Gly Arg Ala Ile Gly Tyr Ser Gln Val Leu Ala
230 235 240 245
gcc atg gca ggg gag atg acc tgg gaa gac gcc ttc gaa cgc acg gtc 883
Ala Met Ala Gly Glu Met Thr Trp Glu Asp Ala Phe Glu Arg Thr Val
250 255 260
acc gga acc aga cgc tat gtc agg cgc caa cgc agc tgg ttc aac aga 931
Thr Gly Thr Arg Arg Tyr Val Arg Arg Gln Arg Ser Trp Phe Asn Arg
265 270 275
gac cac cgc gtg tcc tgg gtc gac gcc tct ggc gat ccc acc gca caa 979
Asp His Arg Val Ser Trp Val Asp Ala Ser Gly Asp Pro Thr Ala Gln
280 285 290
gcc ttg gag att ttg ggt cta caa tagcgagggt gaatttgacc atc 1026
Ala Leu Glu Ile Leu Gly Leu Gln
295 300
<210> 278
<211> 301
<212> PRT
<213> Corynebacterium glutamicum
<400> 278
Val Val Thr Pro Ile Ala Val Val Gly Pro Thr Ala Ser Gly Lys Ser
1 5 10 15
Ala Leu Gly Ile Ala Leu Ala His Lys Leu Asp Gly Glu Val Val Asn
20 25 30
Val Asp Ser Met Gln Leu Tyr Lys Gly Met Asp Ile Gly Thr Ala Lys
35 40 45
Leu Thr Val Glu Glu Arg Glu Gly Ile Ala His His Gln Leu Asp Val
50 55 60
Trp Asp Val Thr Glu Thr Ala Ser Val Ala Arg Phe Gln Ser Asp Ala
65 70 75 80
Val Ala Asp Val Glu Asp Ile Met Ser Arg Gly Lys Thr Pro Ile Leu
85 90 95
Val Gly Gly Ser Met Leu Tyr Val Gln Ser Leu Val Asp Asp Trp Gln
100 105 110
Phe Pro Pro Thr Asp Ser Ala Val Arg Ala Arg Phe Glu Ala Arg Leu
115 120 125
Ala Asp Ile Gly Val Glu Ala Leu His Ala Glu Leu Thr Gln Leu Asp
130 135 140
Pro Glu Ala Ala Ala Val Ile Glu Ser Asn Asp Pro Arg Arg Thr Val
145 150 155 160
Arg Ala Leu Glu Val Ile Glu Leu Thr Gly Gln Pro Phe Gln Ala Ser
165 170 175
Gln Pro Pro Lys Asp Ala Pro Pro Arg Trp Gly Thr Arg Ile Ile Gly
180 185 190
Leu Lys Thr Thr Pro Glu Trp Leu Asn Pro Arg Ile Glu Gln Arg Thr
195 200 205
Ala Arg Met Phe Glu Gln Gly Phe Val Ala Glu Val Glu His Leu Val
210 215 220
Gln Gln Gly Leu Ile Ala Asp Ser Thr Ala Gly Arg Ala Ile Gly Tyr
225 230 235 240
Ser Gln Val Leu Ala Ala Met Ala Gly Glu Met Thr Trp Glu Asp Ala
245 250 255
Phe Glu Arg Thr Val Thr Gly Thr Arg Arg Tyr Val Arg Arg Gln Arg
260 265 270
Ser Trp Phe Asn Arg Asp His Arg Val Ser Trp Val Asp Ala Ser Gly
275 280 285
Asp Pro Thr Ala Gln Ala Leu Glu Ile Leu Gly Leu Gln
290 295 300
<210> 279
<211> 954
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(931)
<223> RXC01971
<400> 279
aggtcttgtt tatttcggct actgattcag tagctgcgct ccgataggat tcttagtttt 60
cagttcagta tctttgagcc acggctagaa tgtgaatcct atg tct aag aag aag 115
Met Ser Lys Lys Lys
1 5
cct cgc ccc att ccg gtt cct gcc caa ttt atc cct ggt ctc att gat 163
Pro Arg Pro Ile Pro Val Pro Ala Gln Phe Ile Pro Gly Leu Ile Asp
10 15 20
gcg cat aca cat ttg gca tcg tgt gga gga gat ctt gca ggg ttg gtg 211
Ala His Thr His Leu Ala Ser Cys Gly Gly Asp Leu Ala Gly Leu Val
25 30 35
gaa agg gcc aag gag gcg ggc gtc gaa aag ctt tgt acc gtc ggt gat 259
Glu Arg Ala Lys Glu Ala Gly Val Glu Lys Leu Cys Thr Val Gly Asp
40 45 50
ggt ttg gct gag gcc gag ctt gcg ctg gag gcc gcg caa cag ttt ggc 307
Gly Leu Ala Glu Ala Glu Leu Ala Leu Glu Ala Ala Gln Gln Phe Gly
55 60 65
aat gtg ttt gct gcg tgt gcg att cat ccg acg aag gct gat cag ttg 355
Asn Val Phe Ala Ala Cys Ala Ile His Pro Thr Lys Ala Asp Gln Leu
70 75 80 85
gat ggg gct gcg cgt gcg cgg ctg acg cag atg gcg gcg gat ccg aat 403
Asp Gly Ala Ala Arg Ala Arg Leu Thr Gln Met Ala Ala Asp Pro Asn
90 95 100
tgt gtg gcc att ggt gag act ggt ttg gat tcg tat tgg atc aag cac 451
Cys Val Ala Ile Gly Glu Thr Gly Leu Asp Ser Tyr Trp Ile Lys His
105 110 115
gat cca gag gac acg gcg gcg ttg gat gtg caa gag gag gcg ctg cgc 499
Asp Pro Glu Asp Thr Ala Ala Leu Asp Val Gln Glu Glu Ala Leu Arg
120 125 130
tgg cat att gat ttg gca att agt gcg gat aag ccg ttg atg att cac 547
Trp His Ile Asp Leu Ala Ile Ser Ala Asp Lys Pro Leu Met Ile His
135 140 145
aat cgt gag gcg gat gct gat ttg atg cga gtg ttg gcg gat gct cca 595
Asn Arg Glu Ala Asp Ala Asp Leu Met Arg Val Leu Ala Asp Ala Pro
150 155 160 165
cct cca aaa gat acg att ctg cat tgt ttt tct tcg ccg ttg gac gtg 643
Pro Pro Lys Asp Thr Ile Leu His Cys Phe Ser Ser Pro Leu Asp Val
170 175 180
gcg aag gaa gcg ttg gat cgt gga tat gtg ttg agt ttt gcg ggc aat 691
Ala Lys Glu Ala Leu Asp Arg Gly Tyr Val Leu Ser Phe Ala Gly Asn
185 190 195
gtg acg ttt aag cgt aat gag gag ttg cgg gag gct gct cgt att gcg 739
Val Thr Phe Lys Arg Asn Glu Glu Leu Arg Glu Ala Ala Arg Ile Ala
200 205 210
ccg att tcc cag att ttg att gaa acc gat gcg ccg tat atg acg ccg 787
Pro Ile Ser Gln Ile Leu Ile Glu Thr Asp Ala Pro Tyr Met Thr Pro
215 220 225
gag ccg ttt cgg ggg agt agg aat gag ccg tcg ttg att ggt cat acg 835
Glu Pro Phe Arg Gly Ser Arg Asn Glu Pro Ser Leu Ile Gly His Thr
230 235 240 245
gcg cta tgc att gcg gag gtt cgg ggg atg gct gtg gag gat gtt gcg 883
Ala Leu Cys Ile Ala Glu Val Arg Gly Met Ala Val Glu Asp Val Ala
250 255 260
gcg gct ttg aat gag aat ttt gat cgc gtt tat ggg gtc aca aat cta 931
Ala Ala Leu Asn Glu Asn Phe Asp Arg Val Tyr Gly Val Thr Asn Leu
265 270 275
taacgtgagg tagctcacag tca 954
<210> 280
<211> 277
<212> PRT
<213> Corynebacterium glutamicum
<400> 280
Met Ser Lys Lys Lys Pro Arg Pro Ile Pro Val Pro Ala Gln Phe Ile
1 5 10 15
Pro Gly Leu Ile Asp Ala His Thr His Leu Ala Ser Cys Gly Gly Asp
20 25 30
Leu Ala Gly Leu Val Glu Arg Ala Lys Glu Ala Gly Val Glu Lys Leu
35 40 45
Cys Thr Val Gly Asp Gly Leu Ala Glu Ala Glu Leu Ala Leu Glu Ala
50 55 60
Ala Gln Gln Phe Gly Asn Val Phe Ala Ala Cys Ala Ile His Pro Thr
65 70 75 80
Lys Ala Asp Gln Leu Asp Gly Ala Ala Arg Ala Arg Leu Thr Gln Met
85 90 95
Ala Ala Asp Pro Asn Cys Val Ala Ile Gly Glu Thr Gly Leu Asp Ser
100 105 110
Tyr Trp Ile Lys His Asp Pro Glu Asp Thr Ala Ala Leu Asp Val Gln
115 120 125
Glu Glu Ala Leu Arg Trp His Ile Asp Leu Ala Ile Ser Ala Asp Lys
130 135 140
Pro Leu Met Ile His Asn Arg Glu Ala Asp Ala Asp Leu Met Arg Val
145 150 155 160
Leu Ala Asp Ala Pro Pro Pro Lys Asp Thr Ile Leu His Cys Phe Ser
165 170 175
Ser Pro Leu Asp Val Ala Lys Glu Ala Leu Asp Arg Gly Tyr Val Leu
180 185 190
Ser Phe Ala Gly Asn Val Thr Phe Lys Arg Asn Glu Glu Leu Arg Glu
195 200 205
Ala Ala Arg Ile Ala Pro Ile Ser Gln Ile Leu Ile Glu Thr Asp Ala
210 215 220
Pro Tyr Met Thr Pro Glu Pro Phe Arg Gly Ser Arg Asn Glu Pro Ser
225 230 235 240
Leu Ile Gly His Thr Ala Leu Cys Ile Ala Glu Val Arg Gly Met Ala
245 250 255
Val Glu Asp Val Ala Ala Ala Leu Asn Glu Asn Phe Asp Arg Val Tyr
260 265 270
Gly Val Thr Asn Leu
275
<210> 281
<211> 1650
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1627)
<223> RXC02697
<400> 281
tttggctcac ctcgatgatg tagacatccc cgatgaggtg cgcgcacagt tgcgggcact 60
ggctatccgc tcaaccgaac gtcggatgta gtagacgcgt atg aca ctt ttt caa 115
Met Thr Leu Phe Gln
1 5
cgt tta acc aac cct gta gtg ctc ggc ggc cta gca ggt gtt ttg ctt 163
Arg Leu Thr Asn Pro Val Val Leu Gly Gly Leu Ala Gly Val Leu Leu
10 15 20
ctg ctc ggc tct ttc ggt ggc ggt gcc att cgg tac cgt ggc gga gtg 211
Leu Leu Gly Ser Phe Gly Gly Gly Ala Ile Arg Tyr Arg Gly Gly Val
25 30 35
ctc gat gcg ttg ggg ctt aac ttc ctt gct ttt ggc cac gcg cag ggt 259
Leu Asp Ala Leu Gly Leu Asn Phe Leu Ala Phe Gly His Ala Gln Gly
40 45 50
att tcc aat acc gtg ttg tgg gtt ggg cag ctg ctg ctg att ggc gcg 307
Ile Ser Asn Thr Val Leu Trp Val Gly Gln Leu Leu Leu Ile Gly Ala
55 60 65
tgg gtt cac ctt gga cgt cgg ttg ttc aag aaa aaa gtc gct gat gac 355
Trp Val His Leu Gly Arg Arg Leu Phe Lys Lys Lys Val Ala Asp Asp
70 75 80 85
acc gca gac gct gct gac tta ggt ctt gta aag cgc acg ttg tat gcc 403
Thr Ala Asp Ala Ala Asp Leu Gly Leu Val Lys Arg Thr Leu Tyr Ala
90 95 100
atg gtg gtg ccc ctc att ttt gcg gca cca atg atg tcg cgt gat gtt 451
Met Val Val Pro Leu Ile Phe Ala Ala Pro Met Met Ser Arg Asp Val
105 110 115
tat tcc tat ctc atg cag ggc gcg atg ctg cgt gat ggc ttc gat ccc 499
Tyr Ser Tyr Leu Met Gln Gly Ala Met Leu Arg Asp Gly Phe Asp Pro
120 125 130
tac act gag ggc gct gcg gta aac cct ggc ccc atg ttg ctt gag gtc 547
Tyr Thr Glu Gly Ala Ala Val Asn Pro Gly Pro Met Leu Leu Glu Val
135 140 145
tct cat gat tgg cgc aac acc acg acg ccg tat ggt cca cta cac ctg 595
Ser His Asp Trp Arg Asn Thr Thr Thr Pro Tyr Gly Pro Leu His Leu
150 155 160 165
tgg att gga gac atg atc acc acg gtt gtg ggc gat aat gtc acc ttg 643
Trp Ile Gly Asp Met Ile Thr Thr Val Val Gly Asp Asn Val Thr Leu
170 175 180
ggc gtc gtc gct tac aag atc ttg tcg atc att ggc ctt gct gtg aca 691
Gly Val Val Ala Tyr Lys Ile Leu Ser Ile Ile Gly Leu Ala Val Thr
185 190 195
ggc tgg agc att gtc cgc att gca caa cat ttt gga gcc aac cca gca 739
Gly Trp Ser Ile Val Arg Ile Ala Gln His Phe Gly Ala Asn Pro Ala
200 205 210
att gca ttg tgg att ggt gtg gcc aat cct gtg atg atc atc cac atg 787
Ile Ala Leu Trp Ile Gly Val Ala Asn Pro Val Met Ile Ile His Met
215 220 225
atc ggc ggc atg cac aat gaa tcc ctc atg gtg gga ttg gtc agc gtc 835
Ile Gly Gly Met His Asn Glu Ser Leu Met Val Gly Leu Val Ser Val
230 235 240 245
ggc ttg ttg cta gca ctg aag aag cgt ttc gtg gca ggt gtg gca ctc 883
Gly Leu Leu Leu Ala Leu Lys Lys Arg Phe Val Ala Gly Val Ala Leu
250 255 260
att gca gtg gct gtg tcg ctg aaa gct aca gcg gcg att gca ctt cct 931
Ile Ala Val Ala Val Ser Leu Lys Ala Thr Ala Ala Ile Ala Leu Pro
265 270 275
ttt gtg gtg tgg atc ggc atg cat cat ttc gca gga ttc tta gcc acc 979
Phe Val Val Trp Ile Gly Met His His Phe Ala Gly Phe Leu Ala Thr
280 285 290
aaa aag ggc aaa gac tcc cct acc ctt aag caa cag gtc ccc gcg ttc 1027
Lys Lys Gly Lys Asp Ser Pro Thr Leu Lys Gln Gln Val Pro Ala Phe
295 300 305
ttt gcc act gga gct gca ggt gtt gct gtc act ggt gtt gtt gtc agt 1075
Phe Ala Thr Gly Ala Ala Gly Val Ala Val Thr Gly Val Val Val Ser
310 315 320 325
gcg atc act tgg gcg tct ggc gct tcg tgg ggc tgg atc agt gag atc 1123
Ala Ile Thr Trp Ala Ser Gly Ala Ser Trp Gly Trp Ile Ser Glu Ile
330 335 340
agt ggc aac agc aag gta atc aac ccg ctg gct ttc cct tct ttg gtg 1171
Ser Gly Asn Ser Lys Val Ile Asn Pro Leu Ala Phe Pro Ser Leu Val
345 350 355
gcc agt gtg atc acc atg gtg gct gaa gtg ttc gtt gac gat ttc gac 1219
Ala Ser Val Ile Thr Met Val Ala Glu Val Phe Val Asp Asp Phe Asp
360 365 370
tac aac gca gtg gtt aat gtt gtg cgc tca atc tcc atg ctg atc atg 1267
Tyr Asn Ala Val Val Asn Val Val Arg Ser Ile Ser Met Leu Ile Met
375 380 385
ctt ggc ggg ttg gtc gta tgt tgg tgg ctg ttc cgc cag aac gaa cgc 1315
Leu Gly Gly Leu Val Val Cys Trp Trp Leu Phe Arg Gln Asn Glu Arg
390 395 400 405
agg gcg gtc act ggt aca gca gcg gct tat gcc gtg gct ttt gtg ttc 1363
Arg Ala Val Thr Gly Thr Ala Ala Ala Tyr Ala Val Ala Phe Val Phe
410 415 420
aat tct gtg acc ttg ccg tgg tac tac gcc agc ttg atc tct ttg ctc 1411
Asn Ser Val Thr Leu Pro Trp Tyr Tyr Ala Ser Leu Ile Ser Leu Leu
425 430 435
ggc aca ttt aaa cca ccg atg tgg ttg att cgc ttc gca gcg ggt gct 1459
Gly Thr Phe Lys Pro Pro Met Trp Leu Ile Arg Phe Ala Ala Gly Ala
440 445 450
tcg gtg ttt atc gcg ctg atg ttt acc gga agt gga aac cac cag ctg 1507
Ser Val Phe Ile Ala Leu Met Phe Thr Gly Ser Gly Asn His Gln Leu
455 460 465
tac aac atc gtt acg gtg atc atc gca gca att atc gcg tgg ctt gcc 1555
Tyr Asn Ile Val Thr Val Ile Ile Ala Ala Ile Ile Ala Trp Leu Ala
470 475 480 485
acc gtg gtg atc ttt gat gac act gac cct gca aca acg gcc acg gag 1603
Thr Val Val Ile Phe Asp Asp Thr Asp Pro Ala Thr Thr Ala Thr Glu
490 495 500
aaa ccc tcc ccg cat acc gtt tcc tagttgcata aggtaaaccg cca 1650
Lys Pro Ser Pro His Thr Val Ser
505
<210> 282
<211> 509
<212> PRT
<213> Corynebacterium glutamicum
<400> 282
Met Thr Leu Phe Gln Arg Leu Thr Asn Pro Val Val Leu Gly Gly Leu
1 5 10 15
Ala Gly Val Leu Leu Leu Leu Gly Ser Phe Gly Gly Gly Ala Ile Arg
20 25 30
Tyr Arg Gly Gly Val Leu Asp Ala Leu Gly Leu Asn Phe Leu Ala Phe
35 40 45
Gly His Ala Gln Gly Ile Ser Asn Thr Val Leu Trp Val Gly Gln Leu
50 55 60
Leu Leu Ile Gly Ala Trp Val His Leu Gly Arg Arg Leu Phe Lys Lys
65 70 75 80
Lys Val Ala Asp Asp Thr Ala Asp Ala Ala Asp Leu Gly Leu Val Lys
85 90 95
Arg Thr Leu Tyr Ala Met Val Val Pro Leu Ile Phe Ala Ala Pro Met
100 105 110
Met Ser Arg Asp Val Tyr Ser Tyr Leu Met Gln Gly Ala Met Leu Arg
115 120 125
Asp Gly Phe Asp Pro Tyr Thr Glu Gly Ala Ala Val Asn Pro Gly Pro
130 135 140
Met Leu Leu Glu Val Ser His Asp Trp Arg Asn Thr Thr Thr Pro Tyr
145 150 155 160
Gly Pro Leu His Leu Trp Ile Gly Asp Met Ile Thr Thr Val Val Gly
165 170 175
Asp Asn Val Thr Leu Gly Val Val Ala Tyr Lys Ile Leu Ser Ile Ile
180 185 190
Gly Leu Ala Val Thr Gly Trp Ser Ile Val Arg Ile Ala Gln His Phe
195 200 205
Gly Ala Asn Pro Ala Ile Ala Leu Trp Ile Gly Val Ala Asn Pro Val
210 215 220
Met Ile Ile His Met Ile Gly Gly Met His Asn Glu Ser Leu Met Val
225 230 235 240
Gly Leu Val Ser Val Gly Leu Leu Leu Ala Leu Lys Lys Arg Phe Val
245 250 255
Ala Gly Val Ala Leu Ile Ala Val Ala Val Ser Leu Lys Ala Thr Ala
260 265 270
Ala Ile Ala Leu Pro Phe Val Val Trp Ile Gly Met His His Phe Ala
275 280 285
Gly Phe Leu Ala Thr Lys Lys Gly Lys Asp Ser Pro Thr Leu Lys Gln
290 295 300
Gln Val Pro Ala Phe Phe Ala Thr Gly Ala Ala Gly Val Ala Val Thr
305 310 315 320
Gly Val Val Val Ser Ala Ile Thr Trp Ala Ser Gly Ala Ser Trp Gly
325 330 335
Trp Ile Ser Glu Ile Ser Gly Asn Ser Lys Val Ile Asn Pro Leu Ala
340 345 350
Phe Pro Ser Leu Val Ala Ser Val Ile Thr Met Val Ala Glu Val Phe
355 360 365
Val Asp Asp Phe Asp Tyr Asn Ala Val Val Asn Val Val Arg Ser Ile
370 375 380
Ser Met Leu Ile Met Leu Gly Gly Leu Val Val Cys Trp Trp Leu Phe
385 390 395 400
Arg Gln Asn Glu Arg Arg Ala Val Thr Gly Thr Ala Ala Ala Tyr Ala
405 410 415
Val Ala Phe Val Phe Asn Ser Val Thr Leu Pro Trp Tyr Tyr Ala Ser
420 425 430
Leu Ile Ser Leu Leu Gly Thr Phe Lys Pro Pro Met Trp Leu Ile Arg
435 440 445
Phe Ala Ala Gly Ala Ser Val Phe Ile Ala Leu Met Phe Thr Gly Ser
450 455 460
Gly Asn His Gln Leu Tyr Asn Ile Val Thr Val Ile Ile Ala Ala Ile
465 470 475 480
Ile Ala Trp Leu Ala Thr Val Val Ile Phe Asp Asp Thr Asp Pro Ala
485 490 495
Thr Thr Ala Thr Glu Lys Pro Ser Pro His Thr Val Ser
500 505
<210> 283
<211> 1298
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(1275)
<223> RXN01946
<400> 283
atc cgc aag tac tcc agg ctc gag gaa caa ttc cag tcg ctc ggc ggc 48
Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly
1 5 10 15
tac gaa gct gac gcc gaa gca gcc cag atc tgc gac aac ctc ggc ctc 96
Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile Cys Asp Asn Leu Gly Leu
20 25 30
gag gca cgc atc ctc gac cag cag ctt aaa acc ctg tcc ggc ggc cag 144
Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln
35 40 45
cgc cgc cgc gtc gag ttg gcg cag atc ctc ttc gcc gcc acc aac ggc 192
Arg Arg Arg Val Glu Leu Ala Gln Ile Leu Phe Ala Ala Thr Asn Gly
50 55 60
tcc ggc aaa tca aaa acc aca ttg ctt ctc gac gag ccc acc aac cac 240
Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His
65 70 75 80
ttg gac gca gac tcg atc acc tgg ctc cgt gac ttc ctg gcg aag cac 288
Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys His
85 90 95
gaa ggt gga ctg atc atg att tcg cac gac gtc gaa ctg ctt ggc gcc 336
Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly Ala
100 105 110
gta tgt aac aag att tgg tac ctc gac gca gta cgc agc gaa gcc gat 384
Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp
115 120 125
gtc tac aac atg ggc ttt agc aaa tac gtc gat gca cgt gca ctc gat 432
Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp
130 135 140
gaa gca cgc cga cgc cgt gag cgc gca aac gcc gaa aag aag gcc gga 480
Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Ala Gly
145 150 155 160
gcc ctc aag gac cag gct gca cgc ctc ggc gcg aaa gca acc aag gct 528
Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys Ala
165 170 175
gcc gca gct aag cag atg atc gcc cgt gcg gaa cga atg atc gac aac 576
Ala Ala Ala Lys Gln Met Ile Ala Arg Ala Glu Arg Met Ile Asp Asn
180 185 190
ctc gac gaa atc cgc gta gct gac cgc gcc gcc aac atc gtt ttc cca 624
Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe Pro
195 200 205
gaa cca gca ccc tgt gga aaa acc cca ctc aac gcc aag ggc ctg acc 672
Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu Thr
210 215 220
aag atg tac ggc tcc ctc gaa gtc ttc gcc ggc gtc gac cta gcc atc 720
Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala Ile
225 230 235 240
gac aaa ggc tcc cgc gta gtc gtc ctc gga ttc aac ggt gca ggt aaa 768
Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys
245 250 255
acc acc ctg ctc aaa ctc ctc gcc ggt gtg gaa cgc acc gac ggc gaa 816
Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly Glu
260 265 270
ggc ggc atc gtc acc gga tac ggc ctc aaa atc ggc tac ttc gcc cag 864
Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys Ile Gly Tyr Phe Ala Gln
275 280 285
gaa cac gac acc atc gac ccc gac aaa tcc gtc tgg caa aac acc atc 912
Glu His Asp Thr Ile Asp Pro Asp Lys Ser Val Trp Gln Asn Thr Ile
290 295 300
gaa gcc tgc gcc gac gcc gac caa caa agc ctc cgc agc ctc ctc gga 960
Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly
305 310 315 320
tcc ttc atg ttc tcc ggc gaa caa ctc gac caa cca gca gga aca ctc 1008
Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Ala Gly Thr Leu
325 330 335
tcc ggc ggt gaa aaa acc cgc ctc gca ctg gcc acc ctc gtg tcc tcc 1056
Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser
340 345 350
cgc gca aac gtc ctg ctt ctc gac gag ccc acc aac aac ctt gac ccg 1104
Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro
355 360 365
atc tcc cgc gaa cag gtc ctc gac gca ctg cgc acc tac acc ggc gca 1152
Ile Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Ala
370 375 380
gtc gtc ctg gtt acc cac gac ccg ggt gca gtc aag gcc ctt gag cca 1200
Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro
385 390 395 400
gaa cgc gtc atc gtg ctt cct gat ggc acc gag gat ctt tgg aat gat 1248
Glu Arg Val Ile Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp
405 410 415
cag tac atg gaa atc gtg gaa ttg gcg taggttctaa ggctgtttat 1295
Gln Tyr Met Glu Ile Val Glu Leu Ala
420 425
gct 1298
<210> 284
<211> 425
<212> PRT
<213> Corynebacterium glutamicum
<400> 284
Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly
1 5 10 15
Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile Cys Asp Asn Leu Gly Leu
20 25 30
Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln
35 40 45
Arg Arg Arg Val Glu Leu Ala Gln Ile Leu Phe Ala Ala Thr Asn Gly
50 55 60
Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His
65 70 75 80
Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys His
85 90 95
Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly Ala
100 105 110
Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp
115 120 125
Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp
130 135 140
Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Ala Gly
145 150 155 160
Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys Ala
165 170 175
Ala Ala Ala Lys Gln Met Ile Ala Arg Ala Glu Arg Met Ile Asp Asn
180 185 190
Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe Pro
195 200 205
Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu Thr
210 215 220
Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala Ile
225 230 235 240
Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys
245 250 255
Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly Glu
260 265 270
Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys Ile Gly Tyr Phe Ala Gln
275 280 285
Glu His Asp Thr Ile Asp Pro Asp Lys Ser Val Trp Gln Asn Thr Ile
290 295 300
Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly
305 310 315 320
Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Ala Gly Thr Leu
325 330 335
Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser
340 345 350
Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro
355 360 365
Ile Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Ala
370 375 380
Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro
385 390 395 400
Glu Arg Val Ile Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp
405 410 415
Gln Tyr Met Glu Ile Val Glu Leu Ala
420 425
<210> 285
<211> 1298
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(1275)
<223> FRXA01946
<400> 285
atc cgc aag tac tcc agg ctc gag gaa caa ttc cag tcg ctc ggc ggc 48
Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly
1 5 10 15
tac gaa gct gac gcc gaa gca gcc cag atc tgc gac aac ctc ggc ctc 96
Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile Cys Asp Asn Leu Gly Leu
20 25 30
gag gca cgc atc ctc gac cag cag ctt aaa acc ctg tcc ggc ggc cag 144
Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln
35 40 45
cgc cgc cgc gtc gag ttg gcg cag atc ctc ttc gcc gcc acc aac ggc 192
Arg Arg Arg Val Glu Leu Ala Gln Ile Leu Phe Ala Ala Thr Asn Gly
50 55 60
tcc ggc aaa tca aaa acc aca ttg ctt ctc gac gag ccc acc aac cac 240
Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His
65 70 75 80
ttg gac gca gac tcg atc acc tgg ctc cgt gac ttc ctg gcg aag cac 288
Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys His
85 90 95
gaa ggt gga ctg atc atg att tcg cac gac gtc gaa ctg ctt ggc gcc 336
Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly Ala
100 105 110
gta tgt aac aag att tgg tac ctc gac gca gta cgc agc gaa gcc gat 384
Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp
115 120 125
gtc tac aac atg ggc ttt agc aaa tac gtc gat gca cgt gca ctc gat 432
Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp
130 135 140
gaa gca cgc cga cgc cgt gag cgc gca aac gcc gaa aag aag gcc gga 480
Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Ala Gly
145 150 155 160
gcc ctc aag gac cag gct gca cgc ctc ggc gcg aaa gca acc aag gct 528
Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys Ala
165 170 175
gcc gca gct aag cag atg atc gcc cgt gcg gaa cga atg atc gac aac 576
Ala Ala Ala Lys Gln Met Ile Ala Arg Ala Glu Arg Met Ile Asp Asn
180 185 190
ctc gac gaa atc cgc gta gct gac cgc gcc gcc aac atc gtt ttc cca 624
Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe Pro
195 200 205
gaa cca gca ccc tgt gga aaa acc cca ctc aac gcc aag ggc ctg acc 672
Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu Thr
210 215 220
aag atg tac ggc tcc ctc gaa gtc ttc gcc ggc gtc gac cta gcc atc 720
Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala Ile
225 230 235 240
gac aaa ggc tcc cgc gta gtc gtc ctc gga ttc aac ggt gca ggt aaa 768
Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys
245 250 255
acc acc ctg ctc aaa ctc ctc gcc ggt gtg gaa cgc acc gac ggc gaa 816
Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly Glu
260 265 270
ggc ggc atc gtc acc gga tac ggc ctc aaa atc ggc tac ttc gcc cag 864
Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys Ile Gly Tyr Phe Ala Gln
275 280 285
gaa cac gac acc atc gac ccc gac aaa tcc gtc tgg caa aac acc atc 912
Glu His Asp Thr Ile Asp Pro Asp Lys Ser Val Trp Gln Asn Thr Ile
290 295 300
gaa gcc tgc gcc gac gcc gac caa caa agc ctc cgc agc ctc ctc gga 960
Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly
305 310 315 320
tcc ttc atg ttc tcc ggc gaa caa ctc gac caa cca gca gga aca ctc 1008
Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Ala Gly Thr Leu
325 330 335
tcc ggc ggt gaa aaa acc cgc ctc gca ctg gcc acc ctc gtg tcc tcc 1056
Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser
340 345 350
cgc gca aac gtc ctg ctt ctc gac gag ccc acc aac aac ctt gac ccg 1104
Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro
355 360 365
atc tcc cgc gaa cag gtc ctc gac gca ctg cgc acc tac acc ggc gca 1152
Ile Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Ala
370 375 380
gtc gtc ctg gtt acc cac gac ccg ggt gca gtc aag gcc ctt gag cca 1200
Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro
385 390 395 400
gaa cgc gtc atc gtg ctt cct gat ggc acc gag gat ctt tgg aat gat 1248
Glu Arg Val Ile Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp
405 410 415
cag tac atg gaa atc gtg gaa ttg gcg taggttctaa ggctgtttat 1295
Gln Tyr Met Glu Ile Val Glu Leu Ala
420 425
gct 1298
<210> 286
<211> 425
<212> PRT
<213> Corynebacterium glutamicum
<400> 286
Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly
1 5 10 15
Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile Cys Asp Asn Leu Gly Leu
20 25 30
Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln
35 40 45
Arg Arg Arg Val Glu Leu Ala Gln Ile Leu Phe Ala Ala Thr Asn Gly
50 55 60
Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His
65 70 75 80
Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys His
85 90 95
Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly Ala
100 105 110
Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp
115 120 125
Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp
130 135 140
Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Ala Gly
145 150 155 160
Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys Ala
165 170 175
Ala Ala Ala Lys Gln Met Ile Ala Arg Ala Glu Arg Met Ile Asp Asn
180 185 190
Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe Pro
195 200 205
Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu Thr
210 215 220
Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala Ile
225 230 235 240
Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys
245 250 255
Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly Glu
260 265 270
Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys Ile Gly Tyr Phe Ala Gln
275 280 285
Glu His Asp Thr Ile Asp Pro Asp Lys Ser Val Trp Gln Asn Thr Ile
290 295 300
Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly
305 310 315 320
Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Ala Gly Thr Leu
325 330 335
Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser
340 345 350
Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro
355 360 365
Ile Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Ala
370 375 380
Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro
385 390 395 400
Glu Arg Val Ile Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp
405 410 415
Gln Tyr Met Glu Ile Val Glu Leu Ala
420 425
<210> 287
<211> 1812
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1789)
<223> RXN00164
<400> 287
ctgctttgcg ggaggttatg aaatgagtgg ggagacgtcg aaaagcatgc gctttccgtt 60
ggccagcctg ccgcaagtgc ggcgcgaggt ggcccggcag gtg ggt cgt att ccg 115
Val Gly Arg Ile Pro
1 5
cgg gcg aag tgg tgg ttt tta ggc gcg ctg gtg ttg ctg agt gcg ggc 163
Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val Leu Leu Ser Ala Gly
10 15 20
gct tat gcg tcg gtg ctg gtg ccg cag gtg ctg ggg cgg att gtg gat 211
Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu Gly Arg Ile Val Asp
25 30 35
ctg gtg tcc gat ggc gcg cag atg cgt gat ttt gtt gag ctc agt gtg 259
Leu Val Ser Asp Gly Ala Gln Met Arg Asp Phe Val Glu Leu Ser Val
40 45 50
att ctc att gcg gtg gca att gcc ggc gcg gtg ctc agt gcg tgc ggg 307
Ile Leu Ile Ala Val Ala Ile Ala Gly Ala Val Leu Ser Ala Cys Gly
55 60 65
ttc tat gtg gtg tcg cgg att tct gag aag att atc gcc aat ttg agg 355
Phe Tyr Val Val Ser Arg Ile Ser Glu Lys Ile Ile Ala Asn Leu Arg
70 75 80 85
gaa gat atg gtg ggc acc gcg ctt ggg ttg ccc acg cac cag gtg gaa 403
Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro Thr His Gln Val Glu
90 95 100
gat gcg ggc tct ggc gat ttg gtg agc cgc tcc acc gat gat gtc tcc 451
Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser Thr Asp Asp Val Ser
105 110 115
gag cta tcc gca gcg gtg aca gag acc gtc ccg att tta agt tcc tca 499
Glu Leu Ser Ala Ala Val Thr Glu Thr Val Pro Ile Leu Ser Ser Ser
120 125 130
ctg ttt acc att gcc gcg acg atc att gcg ctg ttt tct ttg gac tgg 547
Leu Phe Thr Ile Ala Ala Thr Ile Ile Ala Leu Phe Ser Leu Asp Trp
135 140 145
caa ttt gtg ctc att cct gtc gtg gtg gcg ccg gtg tac tac ttc gcg 595
Gln Phe Val Leu Ile Pro Val Val Val Ala Pro Val Tyr Tyr Phe Ala
150 155 160 165
tcc aag cac tat ttg agc aag gcg ccg gat cgg tat gcg gca gaa cgc 643
Ser Lys His Tyr Leu Ser Lys Ala Pro Asp Arg Tyr Ala Ala Glu Arg
170 175 180
gcg gcg atg gcg gag cgt gcg cga aag gta ctt gag gct att cgc ggg 691
Ala Ala Met Ala Glu Arg Ala Arg Lys Val Leu Glu Ala Ile Arg Gly
185 190 195
cgt gca act gtg cgg gcg tat tcc atg gaa gat gcc atg cat aat cag 739
Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp Ala Met His Asn Gln
200 205 210
att gat cag gcg tcg tgg tct gtg gtg gtc aag ggt att cgt gcg cgc 787
Ile Asp Gln Ala Ser Trp Ser Val Val Val Lys Gly Ile Arg Ala Arg
215 220 225
acc acc atg ttg att ttg aac atg tgg atg ctg ttt gcg gaa ttc ctc 835
Thr Thr Met Leu Ile Leu Asn Met Trp Met Leu Phe Ala Glu Phe Leu
230 235 240 245
atg ctc gcg gtc gcg ttg gtg atc ggc tac aag ctg gtc att gat aat 883
Met Leu Ala Val Ala Leu Val Ile Gly Tyr Lys Leu Val Ile Asp Asn
250 255 260
gcg ctg acg atc ggc gcg gtt acc ggt gcc gtg ctg atg att att cgt 931
Ala Leu Thr Ile Gly Ala Val Thr Gly Ala Val Leu Met Ile Ile Arg
265 270 275
ctg cgt ggc ccg atg aat atg ttc atg cgc gtg ctc gac acc att caa 979
Leu Arg Gly Pro Met Asn Met Phe Met Arg Val Leu Asp Thr Ile Gln
280 285 290
tcc ggc tat gcg tcg ctg gcg cgc atc gtg gga gtt gtt gcg gat ccg 1027
Ser Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly Val Val Ala Asp Pro
295 300 305
ccg att cct gtg ccc gac agc ggt gtg aaa gca cct cag ggc aaa gtg 1075
Pro Ile Pro Val Pro Asp Ser Gly Val Lys Ala Pro Gln Gly Lys Val
310 315 320 325
gaa ttg cgc aac gtc agc ttt agc tat ggc gat tcc tgg gcg gtg aaa 1123
Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp Ser Trp Ala Val Lys
330 335 340
gac atc gac atc acg atc aat tcc ggc gaa act gtc gcg ctc gtg ggc 1171
Asp Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr Val Ala Leu Val Gly
345 350 355
gca tct ggc gca ggt aag acg acg gtc gcc gcc ttg ctg gcg ggc ttg 1219
Ala Ser Gly Ala Gly Lys Thr Thr Val Ala Ala Leu Leu Ala Gly Leu
360 365 370
cgg gtg cca gat caa ggg caa gtg ctt gtc gac gac ttc ccc gtc tct 1267
Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp Asp Phe Pro Val Ser
375 380 385
cac ctc tct gac cgc gag cgt atc gcc cgc ttg gcc atg gtc agc cag 1315
His Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu Ala Met Val Ser Gln
390 395 400 405
gag gtt cat gtt ttc tcc ggc acg ctg cgc cag gat ctc acc ttg gct 1363
Glu Val His Val Phe Ser Gly Thr Leu Arg Gln Asp Leu Thr Leu Ala
410 415 420
aaa cca gat gcc tcc gat gag gaa tta gcg cat gct ctt ggg caa gtt 1411
Lys Pro Asp Ala Ser Asp Glu Glu Leu Ala His Ala Leu Gly Gln Val
425 430 435
aat gcc ctt gac tgg ttg gag agt ctt cca gaa gga ctg gac acg gtc 1459
Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu Gly Leu Asp Thr Val
440 445 450
gtt ggt gcg cga gga atc cag cta gaa cca gtg gtg gct cag cag ttg 1507
Val Gly Ala Arg Gly Ile Gln Leu Glu Pro Val Val Ala Gln Gln Leu
455 460 465
gcg ttg gcc cgg gtg ttg ttg ctc aat ccg gcg atc gtc atc atg gat 1555
Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala Ile Val Ile Met Asp
470 475 480 485
gaa gcc acg gca gaa gca gga tcg gcg ggt gcc agc gca ctg gaa gag 1603
Glu Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala Ser Ala Leu Glu Glu
490 495 500
gct gca gat gca gtg agc aag aac cgt tcc gca ttg gtg gtg gcg cac 1651
Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala Leu Val Val Ala His
505 510 515
cgg ttg gat cag gca tcg cgg gct gat cag att ctg gtg atg gat aag 1699
Arg Leu Asp Gln Ala Ser Arg Ala Asp Gln Ile Leu Val Met Asp Lys
520 525 530
ggg gag gtt gtg gaa tcc ggt act cac cag gag tta ttg gat cac ggg 1747
Gly Glu Val Val Glu Ser Gly Thr His Gln Glu Leu Leu Asp His Gly
535 540 545
ggt att tat cag cgt ctg tgg act gcg tgg agt gtc gga aga 1789
Gly Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser Val Gly Arg
550 555 560
tagttgactg ttcaatgcgt tga 1812
<210> 288
<211> 563
<212> PRT
<213> Corynebacterium glutamicum
<400> 288
Val Gly Arg Ile Pro Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val
1 5 10 15
Leu Leu Ser Ala Gly Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu
20 25 30
Gly Arg Ile Val Asp Leu Val Ser Asp Gly Ala Gln Met Arg Asp Phe
35 40 45
Val Glu Leu Ser Val Ile Leu Ile Ala Val Ala Ile Ala Gly Ala Val
50 55 60
Leu Ser Ala Cys Gly Phe Tyr Val Val Ser Arg Ile Ser Glu Lys Ile
65 70 75 80
Ile Ala Asn Leu Arg Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro
85 90 95
Thr His Gln Val Glu Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser
100 105 110
Thr Asp Asp Val Ser Glu Leu Ser Ala Ala Val Thr Glu Thr Val Pro
115 120 125
Ile Leu Ser Ser Ser Leu Phe Thr Ile Ala Ala Thr Ile Ile Ala Leu
130 135 140
Phe Ser Leu Asp Trp Gln Phe Val Leu Ile Pro Val Val Val Ala Pro
145 150 155 160
Val Tyr Tyr Phe Ala Ser Lys His Tyr Leu Ser Lys Ala Pro Asp Arg
165 170 175
Tyr Ala Ala Glu Arg Ala Ala Met Ala Glu Arg Ala Arg Lys Val Leu
180 185 190
Glu Ala Ile Arg Gly Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp
195 200 205
Ala Met His Asn Gln Ile Asp Gln Ala Ser Trp Ser Val Val Val Lys
210 215 220
Gly Ile Arg Ala Arg Thr Thr Met Leu Ile Leu Asn Met Trp Met Leu
225 230 235 240
Phe Ala Glu Phe Leu Met Leu Ala Val Ala Leu Val Ile Gly Tyr Lys
245 250 255
Leu Val Ile Asp Asn Ala Leu Thr Ile Gly Ala Val Thr Gly Ala Val
260 265 270
Leu Met Ile Ile Arg Leu Arg Gly Pro Met Asn Met Phe Met Arg Val
275 280 285
Leu Asp Thr Ile Gln Ser Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly
290 295 300
Val Val Ala Asp Pro Pro Ile Pro Val Pro Asp Ser Gly Val Lys Ala
305 310 315 320
Pro Gln Gly Lys Val Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp
325 330 335
Ser Trp Ala Val Lys Asp Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr
340 345 350
Val Ala Leu Val Gly Ala Ser Gly Ala Gly Lys Thr Thr Val Ala Ala
355 360 365
Leu Leu Ala Gly Leu Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp
370 375 380
Asp Phe Pro Val Ser His Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu
385 390 395 400
Ala Met Val Ser Gln Glu Val His Val Phe Ser Gly Thr Leu Arg Gln
405 410 415
Asp Leu Thr Leu Ala Lys Pro Asp Ala Ser Asp Glu Glu Leu Ala His
420 425 430
Ala Leu Gly Gln Val Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu
435 440 445
Gly Leu Asp Thr Val Val Gly Ala Arg Gly Ile Gln Leu Glu Pro Val
450 455 460
Val Ala Gln Gln Leu Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala
465 470 475 480
Ile Val Ile Met Asp Glu Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala
485 490 495
Ser Ala Leu Glu Glu Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala
500 505 510
Leu Val Val Ala His Arg Leu Asp Gln Ala Ser Arg Ala Asp Gln Ile
515 520 525
Leu Val Met Asp Lys Gly Glu Val Val Glu Ser Gly Thr His Gln Glu
530 535 540
Leu Leu Asp His Gly Gly Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser
545 550 555 560
Val Gly Arg
<210> 289
<211> 1812
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1789)
<223> FRXA00164
<400> 289
ctgctttgcg ggaggttatg aaatgagtgg ggagacgtcg aaaagcatgc gctttccgtt 60
ggccagcctg ccgcaagtgc ggcgcgaggt ggcccggcag gtg ggt cgt att ccg 115
Val Gly Arg Ile Pro
1 5
cgg gcg aag tgg tgg ttt tta ggc gcg ctg gtg ttg ctg agt gcg ggc 163
Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val Leu Leu Ser Ala Gly
10 15 20
gct tat gcg tcg gtg ctg gtg ccg cag gtg ctg ggg cgg att gtg gat 211
Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu Gly Arg Ile Val Asp
25 30 35
ctg gtg tcc gat ggc gcg cag atg cgt gat ttt gtt gag ctc agt gtg 259
Leu Val Ser Asp Gly Ala Gln Met Arg Asp Phe Val Glu Leu Ser Val
40 45 50
att ctc att gcg gtg gca att gcc ggc gcg gtg ctc agt gcg tgc ggg 307
Ile Leu Ile Ala Val Ala Ile Ala Gly Ala Val Leu Ser Ala Cys Gly
55 60 65
ttc tat gtg gtg tcg cgg att tct gag aag att atc gcc aat ttg agg 355
Phe Tyr Val Val Ser Arg Ile Ser Glu Lys Ile Ile Ala Asn Leu Arg
70 75 80 85
gaa gat atg gtg ggc acc gcg ctt ggg ttg ccc acg cac cag gtg gaa 403
Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro Thr His Gln Val Glu
90 95 100
gat gcg ggc tct ggc gat ttg gtg agc cgc tcc acc gat gat gtc tcc 451
Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser Thr Asp Asp Val Ser
105 110 115
gag cta tcc gca gcg gtg aca gag acc gtc ccg att tta agt tcc tca 499
Glu Leu Ser Ala Ala Val Thr Glu Thr Val Pro Ile Leu Ser Ser Ser
120 125 130
ctg ttt acc att gcc gcg acg atc att gcg ctg ttt tct ttg gac tgg 547
Leu Phe Thr Ile Ala Ala Thr Ile Ile Ala Leu Phe Ser Leu Asp Trp
135 140 145
caa ttt gtg ctc att cct gtc gtg gtg gcg ccg gtg tac tac ttc gcg 595
Gln Phe Val Leu Ile Pro Val Val Val Ala Pro Val Tyr Tyr Phe Ala
150 155 160 165
tcc aag cac tat ttg agc aag gcg ccg gat cgg tat gcg gca gaa cgc 643
Ser Lys His Tyr Leu Ser Lys Ala Pro Asp Arg Tyr Ala Ala Glu Arg
170 175 180
gcg gcg atg gcg gag cgt gcg cga aag gta ctt gag gct att cgc ggg 691
Ala Ala Met Ala Glu Arg Ala Arg Lys Val Leu Glu Ala Ile Arg Gly
185 190 195
cgt gca act gtg cgg gcg tat tcc atg gaa gat gcc atg cat aat cag 739
Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp Ala Met His Asn Gln
200 205 210
att gat cag gcg tcg tgg tct gtg gtg gtc aag ggt att cgt gcg cgc 787
Ile Asp Gln Ala Ser Trp Ser Val Val Val Lys Gly Ile Arg Ala Arg
215 220 225
acc acc atg ttg att ttg aac atg tgg atg ctg ttt gcg gaa ttc ctc 835
Thr Thr Met Leu Ile Leu Asn Met Trp Met Leu Phe Ala Glu Phe Leu
230 235 240 245
atg ctc gcg gtc gcg ttg gtg atc ggc tac aag ctg gtc att gat aat 883
Met Leu Ala Val Ala Leu Val Ile Gly Tyr Lys Leu Val Ile Asp Asn
250 255 260
gcg ctg acg atc ggc gcg gtt acc ggt gcc gtg ctg atg att att cgt 931
Ala Leu Thr Ile Gly Ala Val Thr Gly Ala Val Leu Met Ile Ile Arg
265 270 275
ctg cgt ggc ccg atg aat atg ttc atg cgc gtg ctc gac acc att caa 979
Leu Arg Gly Pro Met Asn Met Phe Met Arg Val Leu Asp Thr Ile Gln
280 285 290
tcc ggc tat gcg tcg ctg gcg cgc atc gtg gga gtt gtt gcg gat ccg 1027
Ser Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly Val Val Ala Asp Pro
295 300 305
ccg att cct gtg ccc gac agc ggt gtg aaa gca cct cag ggc aaa gtg 1075
Pro Ile Pro Val Pro Asp Ser Gly Val Lys Ala Pro Gln Gly Lys Val
310 315 320 325
gaa ttg cgc aac gtc agc ttt agc tat ggc gat tcc tgg gcg gtg aaa 1123
Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp Ser Trp Ala Val Lys
330 335 340
gac atc gac atc acg atc aat tcc ggc gaa act gtc gcg ctc gtg ggc 1171
Asp Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr Val Ala Leu Val Gly
345 350 355
gca tct ggc gca ggt aag acg acg gtc gcc gcc ttg ctg gcg ggc ttg 1219
Ala Ser Gly Ala Gly Lys Thr Thr Val Ala Ala Leu Leu Ala Gly Leu
360 365 370
cgg gtg cca gat caa ggg caa gtg ctt gtc gac gac ttc ccc gtc tct 1267
Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp Asp Phe Pro Val Ser
375 380 385
cac ctc tct gac cgc gag cgt atc gcc cgc ttg gcc atg gtc agc cag 1315
His Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu Ala Met Val Ser Gln
390 395 400 405
gag gtt cat gtt ttc tcc ggc acg ctg cgc cag gat ctc acc ttg gct 1363
Glu Val His Val Phe Ser Gly Thr Leu Arg Gln Asp Leu Thr Leu Ala
410 415 420
aaa cca gat gcc tcc gat gag gaa tta gcg cat gct ctt ggg caa gtt 1411
Lys Pro Asp Ala Ser Asp Glu Glu Leu Ala His Ala Leu Gly Gln Val
425 430 435
aat gcc ctt gac tgg ttg gag agt ctt cca gaa gga ctg gac acg gtc 1459
Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu Gly Leu Asp Thr Val
440 445 450
gtt ggt gcg cga gga atc cag cta gaa cca gtg gtg gct cag cag ttg 1507
Val Gly Ala Arg Gly Ile Gln Leu Glu Pro Val Val Ala Gln Gln Leu
455 460 465
gcg ttg gcc cgg gtg ttg ttg ctc aat ccg gcg atc gtc atc atg gat 1555
Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala Ile Val Ile Met Asp
470 475 480 485
gaa gcc acg gca gaa gca gga tcg gcg ggt gcc agc gca ctg gaa gag 1603
Glu Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala Ser Ala Leu Glu Glu
490 495 500
gct gca gat gca gtg agc aag aac cgt tcc gca ttg gtg gtg gcg cac 1651
Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala Leu Val Val Ala His
505 510 515
cgg ttg gat cag gca tcg cgg gct gat cag att ctg gtg atg gat aag 1699
Arg Leu Asp Gln Ala Ser Arg Ala Asp Gln Ile Leu Val Met Asp Lys
520 525 530
ggg gag gtt gtg gaa tcc ggt act cac cag gag tta ttg gat cac ggg 1747
Gly Glu Val Val Glu Ser Gly Thr His Gln Glu Leu Leu Asp His Gly
535 540 545
ggt att tat cag cgt ctg tgg act gcg tgg agt gtc gga aga 1789
Gly Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser Val Gly Arg
550 555 560
tagttgactg ttcaatgcgt tga 1812
<210> 290
<211> 563
<212> PRT
<213> Corynebacterium glutamicum
<400> 290
Val Gly Arg Ile Pro Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val
1 5 10 15
Leu Leu Ser Ala Gly Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu
20 25 30
Gly Arg Ile Val Asp Leu Val Ser Asp Gly Ala Gln Met Arg Asp Phe
35 40 45
Val Glu Leu Ser Val Ile Leu Ile Ala Val Ala Ile Ala Gly Ala Val
50 55 60
Leu Ser Ala Cys Gly Phe Tyr Val Val Ser Arg Ile Ser Glu Lys Ile
65 70 75 80
Ile Ala Asn Leu Arg Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro
85 90 95
Thr His Gln Val Glu Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser
100 105 110
Thr Asp Asp Val Ser Glu Leu Ser Ala Ala Val Thr Glu Thr Val Pro
115 120 125
Ile Leu Ser Ser Ser Leu Phe Thr Ile Ala Ala Thr Ile Ile Ala Leu
130 135 140
Phe Ser Leu Asp Trp Gln Phe Val Leu Ile Pro Val Val Val Ala Pro
145 150 155 160
Val Tyr Tyr Phe Ala Ser Lys His Tyr Leu Ser Lys Ala Pro Asp Arg
165 170 175
Tyr Ala Ala Glu Arg Ala Ala Met Ala Glu Arg Ala Arg Lys Val Leu
180 185 190
Glu Ala Ile Arg Gly Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp
195 200 205
Ala Met His Asn Gln Ile Asp Gln Ala Ser Trp Ser Val Val Val Lys
210 215 220
Gly Ile Arg Ala Arg Thr Thr Met Leu Ile Leu Asn Met Trp Met Leu
225 230 235 240
Phe Ala Glu Phe Leu Met Leu Ala Val Ala Leu Val Ile Gly Tyr Lys
245 250 255
Leu Val Ile Asp Asn Ala Leu Thr Ile Gly Ala Val Thr Gly Ala Val
260 265 270
Leu Met Ile Ile Arg Leu Arg Gly Pro Met Asn Met Phe Met Arg Val
275 280 285
Leu Asp Thr Ile Gln Ser Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly
290 295 300
Val Val Ala Asp Pro Pro Ile Pro Val Pro Asp Ser Gly Val Lys Ala
305 310 315 320
Pro Gln Gly Lys Val Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp
325 330 335
Ser Trp Ala Val Lys Asp Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr
340 345 350
Val Ala Leu Val Gly Ala Ser Gly Ala Gly Lys Thr Thr Val Ala Ala
355 360 365
Leu Leu Ala Gly Leu Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp
370 375 380
Asp Phe Pro Val Ser His Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu
385 390 395 400
Ala Met Val Ser Gln Glu Val His Val Phe Ser Gly Thr Leu Arg Gln
405 410 415
Asp Leu Thr Leu Ala Lys Pro Asp Ala Ser Asp Glu Glu Leu Ala His
420 425 430
Ala Leu Gly Gln Val Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu
435 440 445
Gly Leu Asp Thr Val Val Gly Ala Arg Gly Ile Gln Leu Glu Pro Val
450 455 460
Val Ala Gln Gln Leu Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala
465 470 475 480
Ile Val Ile Met Asp Glu Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala
485 490 495
Ser Ala Leu Glu Glu Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala
500 505 510
Leu Val Val Ala His Arg Leu Asp Gln Ala Ser Arg Ala Asp Gln Ile
515 520 525
Leu Val Met Asp Lys Gly Glu Val Val Glu Ser Gly Thr His Gln Glu
530 535 540
Leu Leu Asp His Gly Gly Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser
545 550 555 560
Val Gly Arg
<210> 291
<211> 1140
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1117)
<223> RXN00243
<400> 291
cactgcgcca gatttttgat gccgacactg tggcaggtgt gcgcgctgag tacgaaaaat 60
ttaacaaagc agcccatgat ggaaatgaag aggaacagaa gtg acc agc gaa caa 115
Val Thr Ser Glu Gln
1 5
gct tta gat cct atc cac cca ggt cag ttc cgt ctt tct cgg att cag 163
Ala Leu Asp Pro Ile His Pro Gly Gln Phe Arg Leu Ser Arg Ile Gln
10 15 20
ttg atc aac tgg gga acc ttc cac gga acg gtg gac att cct gtg acc 211
Leu Ile Asn Trp Gly Thr Phe His Gly Thr Val Asp Ile Pro Val Thr
25 30 35
agg gaa gga atc tta gtt acc ggt ggt tcg gga tca gga aaa tcc acg 259
Arg Glu Gly Ile Leu Val Thr Gly Gly Ser Gly Ser Gly Lys Ser Thr
40 45 50
ctg att gat gcg atc acg gcg gta ttg ctt ccg caa gga aag ctg agg 307
Leu Ile Asp Ala Ile Thr Ala Val Leu Leu Pro Gln Gly Lys Leu Arg
55 60 65
ttt aac tct gcc gca cag gct aat act ccg cgg aat aag gga cgc agt 355
Phe Asn Ser Ala Ala Gln Ala Asn Thr Pro Arg Asn Lys Gly Arg Ser
70 75 80 85
ttg gtt acc tat atc cgt ggc gct tgg cgt gcg cag gag gat ccg ctg 403
Leu Val Thr Tyr Ile Arg Gly Ala Trp Arg Ala Gln Glu Asp Pro Leu
90 95 100
cag gat cag att gtc tcc acg tac cta cgt ccc cgc gca acc tat tcg 451
Gln Asp Gln Ile Val Ser Thr Tyr Leu Arg Pro Arg Ala Thr Tyr Ser
105 110 115
ctg gtt gga ttg act tat tcc aac ggt gaa ggc gtc gag cac acc ttg 499
Leu Val Gly Leu Thr Tyr Ser Asn Gly Glu Gly Val Glu His Thr Leu
120 125 130
gtg gct att ttc tat ctg aaa tcg gga cac aat tta acc tcc gat att 547
Val Ala Ile Phe Tyr Leu Lys Ser Gly His Asn Leu Thr Ser Asp Ile
135 140 145
tct tca tat tat ggt gtg ttt ccc gtt gat caa gac atc aat gcg ctg 595
Ser Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln Asp Ile Asn Ala Leu
150 155 160 165
ctg gat ttc ctg aaa gag ggc atc gat aaa cgc cag atc aga gct gct 643
Leu Asp Phe Leu Lys Glu Gly Ile Asp Lys Arg Gln Ile Arg Ala Ala
170 175 180
ttc aag gaa gcc atc ttt agc gag cag cat tct gta ttc tcc ggc agg 691
Phe Lys Glu Ala Ile Phe Ser Glu Gln His Ser Val Phe Ser Gly Arg
185 190 195
ttt aga agc cgt ttg ggg atc tcc agt gag gaa gct ttg ctg ttg ttg 739
Phe Arg Ser Arg Leu Gly Ile Ser Ser Glu Glu Ala Leu Leu Leu Leu
200 205 210
cac cgc gcg cag tcg gcg aaa gat ctt caa agc ttg gat gat cta ttt 787
His Arg Ala Gln Ser Ala Lys Asp Leu Gln Ser Leu Asp Asp Leu Phe
215 220 225
cgg gat tac atg ctg gtg gaa ccg gat acg ttc agc att gcc aaa act 835
Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe Ser Ile Ala Lys Thr
230 235 240 245
gcc gtg gaa caa ttc caa gac ctt gaa ggt gct tat gag cag gtc gaa 883
Ala Val Glu Gln Phe Gln Asp Leu Glu Gly Ala Tyr Glu Gln Val Glu
250 255 260
gat att aaa cgg cag atc cac acc ctg gat cct ttg gtg cag ctg aag 931
Asp Ile Lys Arg Gln Ile His Thr Leu Asp Pro Leu Val Gln Leu Lys
265 270 275
aat cgg cga gag aaa gcg caa cag tcc aaa gat cat gcc aat gca ctg 979
Asn Arg Arg Glu Lys Ala Gln Gln Ser Lys Asp His Ala Asn Ala Leu
280 285 290
aag aag gcg ctg ccg act gtc ggg aat cgc att aag aag gaa gag caa 1027
Lys Lys Ala Leu Pro Thr Val Gly Asn Arg Ile Lys Lys Glu Glu Gln
295 300 305
gaa ccg ctg gtt cga caa ttt act gtc gag caa acg cag cga agt cga 1075
Glu Pro Leu Val Arg Gln Phe Thr Val Glu Gln Thr Gln Arg Ser Arg
310 315 320 325
agg tgg agt ccg cca aaa ttg aga cag atc gtg ccc gcg aaa 1117
Arg Trp Ser Pro Pro Lys Leu Arg Gln Ile Val Pro Ala Lys
330 335
tgaaaaccct cgcgcacgac aac 1140
<210> 292
<211> 339
<212> PRT
<213> Corynebacterium glutamicum
<400> 292
Val Thr Ser Glu Gln Ala Leu Asp Pro Ile His Pro Gly Gln Phe Arg
1 5 10 15
Leu Ser Arg Ile Gln Leu Ile Asn Trp Gly Thr Phe His Gly Thr Val
20 25 30
Asp Ile Pro Val Thr Arg Glu Gly Ile Leu Val Thr Gly Gly Ser Gly
35 40 45
Ser Gly Lys Ser Thr Leu Ile Asp Ala Ile Thr Ala Val Leu Leu Pro
50 55 60
Gln Gly Lys Leu Arg Phe Asn Ser Ala Ala Gln Ala Asn Thr Pro Arg
65 70 75 80
Asn Lys Gly Arg Ser Leu Val Thr Tyr Ile Arg Gly Ala Trp Arg Ala
85 90 95
Gln Glu Asp Pro Leu Gln Asp Gln Ile Val Ser Thr Tyr Leu Arg Pro
100 105 110
Arg Ala Thr Tyr Ser Leu Val Gly Leu Thr Tyr Ser Asn Gly Glu Gly
115 120 125
Val Glu His Thr Leu Val Ala Ile Phe Tyr Leu Lys Ser Gly His Asn
130 135 140
Leu Thr Ser Asp Ile Ser Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln
145 150 155 160
Asp Ile Asn Ala Leu Leu Asp Phe Leu Lys Glu Gly Ile Asp Lys Arg
165 170 175
Gln Ile Arg Ala Ala Phe Lys Glu Ala Ile Phe Ser Glu Gln His Ser
180 185 190
Val Phe Ser Gly Arg Phe Arg Ser Arg Leu Gly Ile Ser Ser Glu Glu
195 200 205
Ala Leu Leu Leu Leu His Arg Ala Gln Ser Ala Lys Asp Leu Gln Ser
210 215 220
Leu Asp Asp Leu Phe Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe
225 230 235 240
Ser Ile Ala Lys Thr Ala Val Glu Gln Phe Gln Asp Leu Glu Gly Ala
245 250 255
Tyr Glu Gln Val Glu Asp Ile Lys Arg Gln Ile His Thr Leu Asp Pro
260 265 270
Leu Val Gln Leu Lys Asn Arg Arg Glu Lys Ala Gln Gln Ser Lys Asp
275 280 285
His Ala Asn Ala Leu Lys Lys Ala Leu Pro Thr Val Gly Asn Arg Ile
290 295 300
Lys Lys Glu Glu Gln Glu Pro Leu Val Arg Gln Phe Thr Val Glu Gln
305 310 315 320
Thr Gln Arg Ser Arg Arg Trp Ser Pro Pro Lys Leu Arg Gln Ile Val
325 330 335
Pro Ala Lys
<210> 293
<211> 1027
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1027)
<223> FRXA00243
<400> 293
cactgcgcca gatttttgat gccgacactg tggcaggtgt gcgcgctgag tacgaaaaat 60
ttaacaaagc agcccatgat ggaaatgaag aggaacagaa gtg acc agc gaa caa 115
Val Thr Ser Glu Gln
1 5
gct tta gat cct atc cac cca ggt cag ttc cgt ctt tct cgg att cag 163
Ala Leu Asp Pro Ile His Pro Gly Gln Phe Arg Leu Ser Arg Ile Gln
10 15 20
ttg atc aac tgg gga acc ttc cac gga acg gtg gac att cct gtg acc 211
Leu Ile Asn Trp Gly Thr Phe His Gly Thr Val Asp Ile Pro Val Thr
25 30 35
agg gaa gga atc tta gtt acc ggt ggt tcg gga tca gga aaa tcc acg 259
Arg Glu Gly Ile Leu Val Thr Gly Gly Ser Gly Ser Gly Lys Ser Thr
40 45 50
ctg att gat gcg atc acg gcg gta ttg ctt ccg caa gga aag ctg agg 307
Leu Ile Asp Ala Ile Thr Ala Val Leu Leu Pro Gln Gly Lys Leu Arg
55 60 65
ttt aac tct gcc gca cag gct aat act ccg cgg aat aag gga cgc agt 355
Phe Asn Ser Ala Ala Gln Ala Asn Thr Pro Arg Asn Lys Gly Arg Ser
70 75 80 85
ttg gtt acc tat atc cgt ggc gct tgg cgt gcg cag gag gat ccg ctg 403
Leu Val Thr Tyr Ile Arg Gly Ala Trp Arg Ala Gln Glu Asp Pro Leu
90 95 100
cag gat cag att gtc tcc acg tac cta cgt ccc cgc gca acc tat tcg 451
Gln Asp Gln Ile Val Ser Thr Tyr Leu Arg Pro Arg Ala Thr Tyr Ser
105 110 115
ctg gtt gga ttg act tat tcc aac ggt gaa ggc gtc gag cac acc ttg 499
Leu Val Gly Leu Thr Tyr Ser Asn Gly Glu Gly Val Glu His Thr Leu
120 125 130
gtg gct att ttc tat ctg aaa tcg gga cac aat tta acc tcc gat att 547
Val Ala Ile Phe Tyr Leu Lys Ser Gly His Asn Leu Thr Ser Asp Ile
135 140 145
tct tca tat tat ggt gtg ttt ccc gtt gat caa gac atc aat gcg ctg 595
Ser Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln Asp Ile Asn Ala Leu
150 155 160 165
ctg gat ttc ctg aaa gag ggc atc gat aaa cgc cag atc aga gct gct 643
Leu Asp Phe Leu Lys Glu Gly Ile Asp Lys Arg Gln Ile Arg Ala Ala
170 175 180
ttc aag gaa gcc atc ttt agc gag cag cat tct gta ttc tcc ggc agg 691
Phe Lys Glu Ala Ile Phe Ser Glu Gln His Ser Val Phe Ser Gly Arg
185 190 195
ttt aga agc cgt ttg ggg atc tcc agt gag gaa gct ttg ctg ttg ttg 739
Phe Arg Ser Arg Leu Gly Ile Ser Ser Glu Glu Ala Leu Leu Leu Leu
200 205 210
cac cgc gcg cag tcg gcg aaa gat ctt caa agc ttg gat gat cta ttt 787
His Arg Ala Gln Ser Ala Lys Asp Leu Gln Ser Leu Asp Asp Leu Phe
215 220 225
cgg gat tac atg ctg gtg gaa ccg gat acg ttc agc att gcc aaa act 835
Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe Ser Ile Ala Lys Thr
230 235 240 245
gcc gtg gaa caa ttc caa gac ctt gaa ggt gct tat gag cag gtc gaa 883
Ala Val Glu Gln Phe Gln Asp Leu Glu Gly Ala Tyr Glu Gln Val Glu
250 255 260
gat att aaa cgg cag atc cac acc ctg gat cct ttg gtg cag ctg aag 931
Asp Ile Lys Arg Gln Ile His Thr Leu Asp Pro Leu Val Gln Leu Lys
265 270 275
aat cgg cga gag aaa gcg caa cag tcc aaa gat cat gcc aat gca ctg 979
Asn Arg Arg Glu Lys Ala Gln Gln Ser Lys Asp His Ala Asn Ala Leu
280 285 290
aag aag gcg ctg ccg act gtc ggg aat cgc att aag aag gaa gag caa 1027
Lys Lys Ala Leu Pro Thr Val Gly Asn Arg Ile Lys Lys Glu Glu Gln
295 300 305
<210> 294
<211> 309
<212> PRT
<213> Corynebacterium glutamicum
<400> 294
Val Thr Ser Glu Gln Ala Leu Asp Pro Ile His Pro Gly Gln Phe Arg
1 5 10 15
Leu Ser Arg Ile Gln Leu Ile Asn Trp Gly Thr Phe His Gly Thr Val
20 25 30
Asp Ile Pro Val Thr Arg Glu Gly Ile Leu Val Thr Gly Gly Ser Gly
35 40 45
Ser Gly Lys Ser Thr Leu Ile Asp Ala Ile Thr Ala Val Leu Leu Pro
50 55 60
Gln Gly Lys Leu Arg Phe Asn Ser Ala Ala Gln Ala Asn Thr Pro Arg
65 70 75 80
Asn Lys Gly Arg Ser Leu Val Thr Tyr Ile Arg Gly Ala Trp Arg Ala
85 90 95
Gln Glu Asp Pro Leu Gln Asp Gln Ile Val Ser Thr Tyr Leu Arg Pro
100 105 110
Arg Ala Thr Tyr Ser Leu Val Gly Leu Thr Tyr Ser Asn Gly Glu Gly
115 120 125
Val Glu His Thr Leu Val Ala Ile Phe Tyr Leu Lys Ser Gly His Asn
130 135 140
Leu Thr Ser Asp Ile Ser Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln
145 150 155 160
Asp Ile Asn Ala Leu Leu Asp Phe Leu Lys Glu Gly Ile Asp Lys Arg
165 170 175
Gln Ile Arg Ala Ala Phe Lys Glu Ala Ile Phe Ser Glu Gln His Ser
180 185 190
Val Phe Ser Gly Arg Phe Arg Ser Arg Leu Gly Ile Ser Ser Glu Glu
195 200 205
Ala Leu Leu Leu Leu His Arg Ala Gln Ser Ala Lys Asp Leu Gln Ser
210 215 220
Leu Asp Asp Leu Phe Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe
225 230 235 240
Ser Ile Ala Lys Thr Ala Val Glu Gln Phe Gln Asp Leu Glu Gly Ala
245 250 255
Tyr Glu Gln Val Glu Asp Ile Lys Arg Gln Ile His Thr Leu Asp Pro
260 265 270
Leu Val Gln Leu Lys Asn Arg Arg Glu Lys Ala Gln Gln Ser Lys Asp
275 280 285
His Ala Asn Ala Leu Lys Lys Ala Leu Pro Thr Val Gly Asn Arg Ile
290 295 300
Lys Lys Glu Glu Gln
305
<210> 295
<211> 2325
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(2302)
<223> RXA00259
<400> 295
ggccttatta acatacggcg gttctagcac acagcgatgg atgatgtgtc ccaccgatat 60
tgctgcatgt gccaagattt agcacggtac agtgctagaa atg agc gga ctg ttt 115
Met Ser Gly Leu Phe
1 5
acc cca ttt tca gat gcg gca aaa aac aac acg gta aaa act gat gga 163
Thr Pro Phe Ser Asp Ala Ala Lys Asn Asn Thr Val Lys Thr Asp Gly
10 15 20
gat tca gta tct ggt cga gac ttg cct att act aag atc tct gag gat 211
Asp Ser Val Ser Gly Arg Asp Leu Pro Ile Thr Lys Ile Ser Glu Asp
25 30 35
cgt ttc gag cgt tct gcg tat tca gcc cag ctg gca aat ata atc tgc 259
Arg Phe Glu Arg Ser Ala Tyr Ser Ala Gln Leu Ala Asn Ile Ile Cys
40 45 50
gat gtg gca cct tgg gga gcg agc act gtt ttc agt ctt act ggt cag 307
Asp Val Ala Pro Trp Gly Ala Ser Thr Val Phe Ser Leu Thr Gly Gln
55 60 65
tgg ggc agt ggt aag aca tct ctt gtt aat ttg att cgc tcg gaa gaa 355
Trp Gly Ser Gly Lys Thr Ser Leu Val Asn Leu Ile Arg Ser Glu Glu
70 75 80 85
tct cta tcg aac gaa aaa tgg aca atc gtt gat ttc aac ccg tgg gtg 403
Ser Leu Ser Asn Glu Lys Trp Thr Ile Val Asp Phe Asn Pro Trp Val
90 95 100
gcc tct gac ccg caa tct ttg att gag gag ttt tac cga gta atc gtt 451
Ala Ser Asp Pro Gln Ser Leu Ile Glu Glu Phe Tyr Arg Val Ile Val
105 110 115
ggg acg gta cct gat gat aag acc ggc caa aag atc aaa act gtt ctg 499
Gly Thr Val Pro Asp Asp Lys Thr Gly Gln Lys Ile Lys Thr Val Leu
120 125 130
cag aaa acc ttt agc acg att ggg tca att gca ggt ggg gtc gga ggg 547
Gln Lys Thr Phe Ser Thr Ile Gly Ser Ile Ala Gly Gly Val Gly Gly
135 140 145
ttt ggt gtc cta gaa gca ctt gcg ctc tca aaa gga gta gat gct gca 595
Phe Gly Val Leu Glu Ala Leu Ala Leu Ser Lys Gly Val Asp Ala Ala
150 155 160 165
aac gct gta tat aag aca tgg aaa cag gag caa gat tcg tgg cca acg 643
Asn Ala Val Tyr Lys Thr Trp Lys Gln Glu Gln Asp Ser Trp Pro Thr
170 175 180
ctg tat aca cgt gct gcg aac cat ttt aaa gat ctg aac aag cga att 691
Leu Tyr Thr Arg Ala Ala Asn His Phe Lys Asp Leu Asn Lys Arg Ile
185 190 195
ctc att gtc gtc gat gat att gat cgc ctc cat act gat gaa ttg gcg 739
Leu Ile Val Val Asp Asp Ile Asp Arg Leu His Thr Asp Glu Leu Ala
200 205 210
ctg tta atg aaa gta ata cgc ttg ctt gga cga ttc ccg cag gtg aat 787
Leu Leu Met Lys Val Ile Arg Leu Leu Gly Arg Phe Pro Gln Val Asn
215 220 225
tat ctt ttg gtt tat gaa gaa gaa tca ctg tta acg acg cta gcc aga 835
Tyr Leu Leu Val Tyr Glu Glu Glu Ser Leu Leu Thr Thr Leu Ala Arg
230 235 240 245
tcg aca gct gta ggt ggt agc gaa gat gat gct ttg cgt ttc atg gag 883
Ser Thr Ala Val Gly Gly Ser Glu Asp Asp Ala Leu Arg Phe Met Glu
250 255 260
aaa atc gtg cag tat cct ttc gat gtt ccg cct ctg aca tca ttt caa 931
Lys Ile Val Gln Tyr Pro Phe Asp Val Pro Pro Leu Thr Ser Phe Gln
265 270 275
ata gag aaa gag ctc agt gca tta ttt gac aag ctt ttc cag ggt gtt 979
Ile Glu Lys Glu Leu Ser Ala Leu Phe Asp Lys Leu Phe Gln Gly Val
280 285 290
tcg cta tcg ggt gat cct gaa gac ttt gca cta gtg aag tcg aga atg 1027
Ser Leu Ser Gly Asp Pro Glu Asp Phe Ala Leu Val Lys Ser Arg Met
295 300 305
ttc gat gtc tgg gaa aag act ctg gtc acg ccg agg ctg ttg cac cgt 1075
Phe Asp Val Trp Glu Lys Thr Leu Val Thr Pro Arg Leu Leu His Arg
310 315 320 325
ttt gct gct cta cta acc aac tgg act cgg ata tat gga tca ggt gaa 1123
Phe Ala Ala Leu Leu Thr Asn Trp Thr Arg Ile Tyr Gly Ser Gly Glu
330 335 340
gtt aac ggc gtt gat ctc aca ata ctt gcg acc att cga att gtt ttt 1171
Val Asn Gly Val Asp Leu Thr Ile Leu Ala Thr Ile Arg Ile Val Phe
345 350 355
ccg tct gtg tat aaa cgt ctt tct cga gcg aag gaa gta ttg ctt caa 1219
Pro Ser Val Tyr Lys Arg Leu Ser Arg Ala Lys Glu Val Leu Leu Gln
360 365 370
gga ggt cga acg aca ggc tcg cag aaa ccc ggt tgg gaa aag caa tta 1267
Gly Gly Arg Thr Thr Gly Ser Gln Lys Pro Gly Trp Glu Lys Gln Leu
375 380 385
tgt gag ggg atg aac aac gag cag atg gat ctt tta aag acc atg ctt 1315
Cys Glu Gly Met Asn Asn Glu Gln Met Asp Leu Leu Lys Thr Met Leu
390 395 400 405
ttg ttc ctt ttc cca cgt ctt tcg gat cac cct agt acg aga atg cat 1363
Leu Phe Leu Phe Pro Arg Leu Ser Asp His Pro Ser Thr Arg Met His
410 415 420
cgt gag agg ggg atc tcg acg gaa gtt tat ttt gac acg tac ctc atg 1411
Arg Glu Arg Gly Ile Ser Thr Glu Val Tyr Phe Asp Thr Tyr Leu Met
425 430 435
ttt caa aga cct gga cat gtc ata agt gat gaa cag ttg gat aag tat 1459
Phe Gln Arg Pro Gly His Val Ile Ser Asp Glu Gln Leu Asp Lys Tyr
440 445 450
cta tct aat gcg gac gat gct atg ggt ttc gtc gat tta att aac tcc 1507
Leu Ser Asn Ala Asp Asp Ala Met Gly Phe Val Asp Leu Ile Asn Ser
455 460 465
gat gac aat gac atg gtg gca tca gtg atg aaa aag ctt cct cta gca 1555
Asp Asp Asn Asp Met Val Ala Ser Val Met Lys Lys Leu Pro Leu Ala
470 475 480 485
att gat cga ctt gat gga gag ggt gtt agg cac atg gca gtt gag gtg 1603
Ile Asp Arg Leu Asp Gly Glu Gly Val Arg His Met Ala Val Glu Val
490 495 500
tta ttc acc gct gct aat ggt atg cat gat aaa ggt cgt caa gtg cgt 1651
Leu Phe Thr Ala Ala Asn Gly Met His Asp Lys Gly Arg Gln Val Arg
505 510 515
atg agc ggc ata ttc agt gac ctg tat tcc cat gcg tgc tcg att ctt 1699
Met Ser Gly Ile Phe Ser Asp Leu Tyr Ser His Ala Cys Ser Ile Leu
520 525 530
ggt gca ttg cct caa tta cca gtg gaa caa ctc tat gag aaa ttc ttt 1747
Gly Ala Leu Pro Gln Leu Pro Val Glu Gln Leu Tyr Glu Lys Phe Phe
535 540 545
tct gag atg acg ctt aat gag gct gct ttc tgg tta aac cag gtg ggg 1795
Ser Glu Met Thr Leu Asn Glu Ala Ala Phe Trp Leu Asn Gln Val Gly
550 555 560 565
gaa agg gct aga gcc tgt ggt aat gat gta agt ggc ctt gag ctt ttt 1843
Glu Arg Ala Arg Ala Cys Gly Asn Asp Val Ser Gly Leu Glu Leu Phe
570 575 580
cgt aaa gtt aat ata aag acc gaa gct aga att tta agt gta ttg aag 1891
Arg Lys Val Asn Ile Lys Thr Glu Ala Arg Ile Leu Ser Val Leu Lys
585 590 595
aat cag gac ccc tca gat tgg gat tta ggt cca tat tcg ctt ggt att 1939
Asn Gln Asp Pro Ser Asp Trp Asp Leu Gly Pro Tyr Ser Leu Gly Ile
600 605 610
ttg gcg aaa agc tcg aat ttt tct tca gtg ctg aag tct ctg caa agt 1987
Leu Ala Lys Ser Ser Asn Phe Ser Ser Val Leu Lys Ser Leu Gln Ser
615 620 625
ggt ata gag gaa cat cag ttt gat gtg ata gat att gga gtg ctt ttc 2035
Gly Ile Glu Glu His Gln Phe Asp Val Ile Asp Ile Gly Val Leu Phe
630 635 640 645
tta acg act gtg tat tct tcg cga cag gga cca agc ggt ggt gca tgg 2083
Leu Thr Thr Val Tyr Ser Ser Arg Gln Gly Pro Ser Gly Gly Ala Trp
650 655 660
ata gat tct ttt cag cat agt ctg ttt tca cgg tac gta cct gat tct 2131
Ile Asp Ser Phe Gln His Ser Leu Phe Ser Arg Tyr Val Pro Asp Ser
665 670 675
cta cgg gct ata acc aag tct gaa gta gat gta gaa cta ggt aag ata 2179
Leu Arg Ala Ile Thr Lys Ser Glu Val Asp Val Glu Leu Gly Lys Ile
680 685 690
cag ttc acg gat ttt agc tgg gaa ggg aag cga aaa gtt gtc gca tat 2227
Gln Phe Thr Asp Phe Ser Trp Glu Gly Lys Arg Lys Val Val Ala Tyr
695 700 705
gca ctg gag act gga aga agt gat ttc act cga gaa cga tta ggg ggc 2275
Ala Leu Glu Thr Gly Arg Ser Asp Phe Thr Arg Glu Arg Leu Gly Gly
710 715 720 725
tac agt atc gca gat tct ata gtc gat tgatgaggct gaggtcatga 2322
Tyr Ser Ile Ala Asp Ser Ile Val Asp
730
ctt 2325
<210> 296
<211> 734
<212> PRT
<213> Corynebacterium glutamicum
<400> 296
Met Ser Gly Leu Phe Thr Pro Phe Ser Asp Ala Ala Lys Asn Asn Thr
1 5 10 15
Val Lys Thr Asp Gly Asp Ser Val Ser Gly Arg Asp Leu Pro Ile Thr
20 25 30
Lys Ile Ser Glu Asp Arg Phe Glu Arg Ser Ala Tyr Ser Ala Gln Leu
35 40 45
Ala Asn Ile Ile Cys Asp Val Ala Pro Trp Gly Ala Ser Thr Val Phe
50 55 60
Ser Leu Thr Gly Gln Trp Gly Ser Gly Lys Thr Ser Leu Val Asn Leu
65 70 75 80
Ile Arg Ser Glu Glu Ser Leu Ser Asn Glu Lys Trp Thr Ile Val Asp
85 90 95
Phe Asn Pro Trp Val Ala Ser Asp Pro Gln Ser Leu Ile Glu Glu Phe
100 105 110
Tyr Arg Val Ile Val Gly Thr Val Pro Asp Asp Lys Thr Gly Gln Lys
115 120 125
Ile Lys Thr Val Leu Gln Lys Thr Phe Ser Thr Ile Gly Ser Ile Ala
130 135 140
Gly Gly Val Gly Gly Phe Gly Val Leu Glu Ala Leu Ala Leu Ser Lys
145 150 155 160
Gly Val Asp Ala Ala Asn Ala Val Tyr Lys Thr Trp Lys Gln Glu Gln
165 170 175
Asp Ser Trp Pro Thr Leu Tyr Thr Arg Ala Ala Asn His Phe Lys Asp
180 185 190
Leu Asn Lys Arg Ile Leu Ile Val Val Asp Asp Ile Asp Arg Leu His
195 200 205
Thr Asp Glu Leu Ala Leu Leu Met Lys Val Ile Arg Leu Leu Gly Arg
210 215 220
Phe Pro Gln Val Asn Tyr Leu Leu Val Tyr Glu Glu Glu Ser Leu Leu
225 230 235 240
Thr Thr Leu Ala Arg Ser Thr Ala Val Gly Gly Ser Glu Asp Asp Ala
245 250 255
Leu Arg Phe Met Glu Lys Ile Val Gln Tyr Pro Phe Asp Val Pro Pro
260 265 270
Leu Thr Ser Phe Gln Ile Glu Lys Glu Leu Ser Ala Leu Phe Asp Lys
275 280 285
Leu Phe Gln Gly Val Ser Leu Ser Gly Asp Pro Glu Asp Phe Ala Leu
290 295 300
Val Lys Ser Arg Met Phe Asp Val Trp Glu Lys Thr Leu Val Thr Pro
305 310 315 320
Arg Leu Leu His Arg Phe Ala Ala Leu Leu Thr Asn Trp Thr Arg Ile
325 330 335
Tyr Gly Ser Gly Glu Val Asn Gly Val Asp Leu Thr Ile Leu Ala Thr
340 345 350
Ile Arg Ile Val Phe Pro Ser Val Tyr Lys Arg Leu Ser Arg Ala Lys
355 360 365
Glu Val Leu Leu Gln Gly Gly Arg Thr Thr Gly Ser Gln Lys Pro Gly
370 375 380
Trp Glu Lys Gln Leu Cys Glu Gly Met Asn Asn Glu Gln Met Asp Leu
385 390 395 400
Leu Lys Thr Met Leu Leu Phe Leu Phe Pro Arg Leu Ser Asp His Pro
405 410 415
Ser Thr Arg Met His Arg Glu Arg Gly Ile Ser Thr Glu Val Tyr Phe
420 425 430
Asp Thr Tyr Leu Met Phe Gln Arg Pro Gly His Val Ile Ser Asp Glu
435 440 445
Gln Leu Asp Lys Tyr Leu Ser Asn Ala Asp Asp Ala Met Gly Phe Val
450 455 460
Asp Leu Ile Asn Ser Asp Asp Asn Asp Met Val Ala Ser Val Met Lys
465 470 475 480
Lys Leu Pro Leu Ala Ile Asp Arg Leu Asp Gly Glu Gly Val Arg His
485 490 495
Met Ala Val Glu Val Leu Phe Thr Ala Ala Asn Gly Met His Asp Lys
500 505 510
Gly Arg Gln Val Arg Met Ser Gly Ile Phe Ser Asp Leu Tyr Ser His
515 520 525
Ala Cys Ser Ile Leu Gly Ala Leu Pro Gln Leu Pro Val Glu Gln Leu
530 535 540
Tyr Glu Lys Phe Phe Ser Glu Met Thr Leu Asn Glu Ala Ala Phe Trp
545 550 555 560
Leu Asn Gln Val Gly Glu Arg Ala Arg Ala Cys Gly Asn Asp Val Ser
565 570 575
Gly Leu Glu Leu Phe Arg Lys Val Asn Ile Lys Thr Glu Ala Arg Ile
580 585 590
Leu Ser Val Leu Lys Asn Gln Asp Pro Ser Asp Trp Asp Leu Gly Pro
595 600 605
Tyr Ser Leu Gly Ile Leu Ala Lys Ser Ser Asn Phe Ser Ser Val Leu
610 615 620
Lys Ser Leu Gln Ser Gly Ile Glu Glu His Gln Phe Asp Val Ile Asp
625 630 635 640
Ile Gly Val Leu Phe Leu Thr Thr Val Tyr Ser Ser Arg Gln Gly Pro
645 650 655
Ser Gly Gly Ala Trp Ile Asp Ser Phe Gln His Ser Leu Phe Ser Arg
660 665 670
Tyr Val Pro Asp Ser Leu Arg Ala Ile Thr Lys Ser Glu Val Asp Val
675 680 685
Glu Leu Gly Lys Ile Gln Phe Thr Asp Phe Ser Trp Glu Gly Lys Arg
690 695 700
Lys Val Val Ala Tyr Ala Leu Glu Thr Gly Arg Ser Asp Phe Thr Arg
705 710 715 720
Glu Arg Leu Gly Gly Tyr Ser Ile Ala Asp Ser Ile Val Asp
725 730
<210> 297
<211> 789
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(766)
<223> RXN00410
<400> 297
gtgttgatgc gttagtccac ccacgcagct acgccccaaa ggaataatct tgaaccctgc 60
cacagataac gctccgccgg tcctttcagc ccaagatctc atg atg atc tat gga 115
Met Met Ile Tyr Gly
1 5
aaa gga tca aca gaa gtt cgg gct ctc gat ggc att tct gta cag att 163
Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly Ile Ser Val Gln Ile
10 15 20
cag tcc gac aaa tgg acc tcc atc atg ggg caa tca ggc tct ggc aaa 211
Gln Ser Asp Lys Trp Thr Ser Ile Met Gly Gln Ser Gly Ser Gly Lys
25 30 35
aca act ctg ttg cag tgc ctt tcc gga ttg gcg cag cca acc tca ggc 259
Thr Thr Leu Leu Gln Cys Leu Ser Gly Leu Ala Gln Pro Thr Ser Gly
40 45 50
aga gtg aca ctg aac aaa aac aac atc acg ttg agc tcc ctg tca gaa 307
Arg Val Thr Leu Asn Lys Asn Asn Ile Thr Leu Ser Ser Leu Ser Glu
55 60 65
aat aag cgt gcc aag ctg cgt cgc acg cac atc agc atg gtg ttt cag 355
Asn Lys Arg Ala Lys Leu Arg Arg Thr His Ile Ser Met Val Phe Gln
70 75 80 85
gat ttc aac ttg gtg cct att ttg tcg gtg aag gac aat att ttg ctg 403
Asp Phe Asn Leu Val Pro Ile Leu Ser Val Lys Asp Asn Ile Leu Leu
90 95 100
ccg ttg cgt ctt gcg cat cgc agg gtg gat aag cag tgg ttt gaa cac 451
Pro Leu Arg Leu Ala His Arg Arg Val Asp Lys Gln Trp Phe Glu His
105 110 115
atc acc agt gtg ttg aag att gat aat cgt atg cgc cat ttg cct ggg 499
Ile Thr Ser Val Leu Lys Ile Asp Asn Arg Met Arg His Leu Pro Gly
120 125 130
gag ctg tct ggc ggt cag caa caa cgc gcc gcg att gcc cgg gcg ttg 547
Glu Leu Ser Gly Gly Gln Gln Gln Arg Ala Ala Ile Ala Arg Ala Leu
135 140 145
atg tct agg ccc gat att gtc att gcg gat gag cca aca gga agt ttg 595
Met Ser Arg Pro Asp Ile Val Ile Ala Asp Glu Pro Thr Gly Ser Leu
150 155 160 165
gat tcc gtc acc agc gat gca gtg ttg aat ttg ttc cgc agc att gtt 643
Asp Ser Val Thr Ser Asp Ala Val Leu Asn Leu Phe Arg Ser Ile Val
170 175 180
gat gat ttt ggg cag tca ctt gtg ttt gtc acc cac gat aaa gat gct 691
Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr His Asp Lys Asp Ala
185 190 195
gct cac cgt ggt gac gtg ttg atc aca atg cgt gat ggc aag atc atc 739
Ala His Arg Gly Asp Val Leu Ile Thr Met Arg Asp Gly Lys Ile Ile
200 205 210
gat acg gca gat ttg cgg gtg ggg cgt taatgttcag gcttgctttc 786
Asp Thr Ala Asp Leu Arg Val Gly Arg
215 220
gct 789
<210> 298
<211> 222
<212> PRT
<213> Corynebacterium glutamicum
<400> 298
Met Met Ile Tyr Gly Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly
1 5 10 15
Ile Ser Val Gln Ile Gln Ser Asp Lys Trp Thr Ser Ile Met Gly Gln
20 25 30
Ser Gly Ser Gly Lys Thr Thr Leu Leu Gln Cys Leu Ser Gly Leu Ala
35 40 45
Gln Pro Thr Ser Gly Arg Val Thr Leu Asn Lys Asn Asn Ile Thr Leu
50 55 60
Ser Ser Leu Ser Glu Asn Lys Arg Ala Lys Leu Arg Arg Thr His Ile
65 70 75 80
Ser Met Val Phe Gln Asp Phe Asn Leu Val Pro Ile Leu Ser Val Lys
85 90 95
Asp Asn Ile Leu Leu Pro Leu Arg Leu Ala His Arg Arg Val Asp Lys
100 105 110
Gln Trp Phe Glu His Ile Thr Ser Val Leu Lys Ile Asp Asn Arg Met
115 120 125
Arg His Leu Pro Gly Glu Leu Ser Gly Gly Gln Gln Gln Arg Ala Ala
130 135 140
Ile Ala Arg Ala Leu Met Ser Arg Pro Asp Ile Val Ile Ala Asp Glu
145 150 155 160
Pro Thr Gly Ser Leu Asp Ser Val Thr Ser Asp Ala Val Leu Asn Leu
165 170 175
Phe Arg Ser Ile Val Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr
180 185 190
His Asp Lys Asp Ala Ala His Arg Gly Asp Val Leu Ile Thr Met Arg
195 200 205
Asp Gly Lys Ile Ile Asp Thr Ala Asp Leu Arg Val Gly Arg
210 215 220
<210> 299
<211> 789
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(766)
<223> FRXA00410
<400> 299
gtgttgatgc gttagtccac ccacgcagct acgccccaaa ggaataatct tgaaccctgc 60
cacagataac gctccgccgg tcctttcagc ccaagatctc atg atg atc tat gga 115
Met Met Ile Tyr Gly
1 5
aaa gga tca aca gaa gtt cgg gct ctc gat ggc att tct gta cag att 163
Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly Ile Ser Val Gln Ile
10 15 20
cag tcc gac aaa tgg acc tcc atc atg ggg caa tca ggc tct ggc aaa 211
Gln Ser Asp Lys Trp Thr Ser Ile Met Gly Gln Ser Gly Ser Gly Lys
25 30 35
aca act ctg ttg cag tgc ctt tcc gga ttg gcg cag cca acc tca ggc 259
Thr Thr Leu Leu Gln Cys Leu Ser Gly Leu Ala Gln Pro Thr Ser Gly
40 45 50
aga gtg aca ctg aac aaa aac aac atc acg ttg agc tcc ctg tca gaa 307
Arg Val Thr Leu Asn Lys Asn Asn Ile Thr Leu Ser Ser Leu Ser Glu
55 60 65
aat aag cgt gcc aag ctg cgt cgc acg cac atc agc atg gtg ttt cag 355
Asn Lys Arg Ala Lys Leu Arg Arg Thr His Ile Ser Met Val Phe Gln
70 75 80 85
gat ttc aac ttg gtg cct att ttg tcg gtg aag gac aat att ttg ctg 403
Asp Phe Asn Leu Val Pro Ile Leu Ser Val Lys Asp Asn Ile Leu Leu
90 95 100
ccg ttg cgt ctt gcg cat cgc agg gtg gat aag cag tgg ttt gaa cac 451
Pro Leu Arg Leu Ala His Arg Arg Val Asp Lys Gln Trp Phe Glu His
105 110 115
atc acc agt gtg ttg aag att gat aat cgt atg cgc cat ttg cct ggg 499
Ile Thr Ser Val Leu Lys Ile Asp Asn Arg Met Arg His Leu Pro Gly
120 125 130
gag ctg tct ggc ggt cag caa caa cgc gcc gcg att gcc cgg gcg ttg 547
Glu Leu Ser Gly Gly Gln Gln Gln Arg Ala Ala Ile Ala Arg Ala Leu
135 140 145
atg tct agg ccc gat att gtc att gcg gat gag cca aca gga agt ttg 595
Met Ser Arg Pro Asp Ile Val Ile Ala Asp Glu Pro Thr Gly Ser Leu
150 155 160 165
gat tcc gtc acc agc gat gca gtg ttg aat ttg ttc cgc agc att gtt 643
Asp Ser Val Thr Ser Asp Ala Val Leu Asn Leu Phe Arg Ser Ile Val
170 175 180
gat gat ttt ggg cag tca ctt gtg ttt gtc acc cac gat aaa gat gct 691
Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr His Asp Lys Asp Ala
185 190 195
gct cac cgt ggt gac gtg ttg atc aca atg cgt gat ggc aag atc atc 739
Ala His Arg Gly Asp Val Leu Ile Thr Met Arg Asp Gly Lys Ile Ile
200 205 210
gat acg gca gat ttg cgg gtg ggg cgt taatgttcag gcttgctttc 786
Asp Thr Ala Asp Leu Arg Val Gly Arg
215 220
gct 789
<210> 300
<211> 222
<212> PRT
<213> Corynebacterium glutamicum
<400> 300
Met Met Ile Tyr Gly Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly
1 5 10 15
Ile Ser Val Gln Ile Gln Ser Asp Lys Trp Thr Ser Ile Met Gly Gln
20 25 30
Ser Gly Ser Gly Lys Thr Thr Leu Leu Gln Cys Leu Ser Gly Leu Ala
35 40 45
Gln Pro Thr Ser Gly Arg Val Thr Leu Asn Lys Asn Asn Ile Thr Leu
50 55 60
Ser Ser Leu Ser Glu Asn Lys Arg Ala Lys Leu Arg Arg Thr His Ile
65 70 75 80
Ser Met Val Phe Gln Asp Phe Asn Leu Val Pro Ile Leu Ser Val Lys
85 90 95
Asp Asn Ile Leu Leu Pro Leu Arg Leu Ala His Arg Arg Val Asp Lys
100 105 110
Gln Trp Phe Glu His Ile Thr Ser Val Leu Lys Ile Asp Asn Arg Met
115 120 125
Arg His Leu Pro Gly Glu Leu Ser Gly Gly Gln Gln Gln Arg Ala Ala
130 135 140
Ile Ala Arg Ala Leu Met Ser Arg Pro Asp Ile Val Ile Ala Asp Glu
145 150 155 160
Pro Thr Gly Ser Leu Asp Ser Val Thr Ser Asp Ala Val Leu Asn Leu
165 170 175
Phe Arg Ser Ile Val Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr
180 185 190
His Asp Lys Asp Ala Ala His Arg Gly Asp Val Leu Ile Thr Met Arg
195 200 205
Asp Gly Lys Ile Ile Asp Thr Ala Asp Leu Arg Val Gly Arg
210 215 220
<210> 301
<211> 1500
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1477)
<223> RXN00456
<400> 301
ctcaccaacc cggagatcgt cacagcggtg ctaacggatc atgcctagct tatggcgtgc 60
tcgtcgcaga cttttgctca ttgccctagg tgtacttggt gtg ctg cag gca ctg 115
Val Leu Gln Ala Leu
1 5
ctg gcg atc atg gtg tcg ttg agc gta gcc gcc ata ctt gag gga aac 163
Leu Ala Ile Met Val Ser Leu Ser Val Ala Ala Ile Leu Glu Gly Asn
10 15 20
cga gca ctt gtt gga ttg ctg ctt gct acc acg ttg ggt ttg ggg gtg 211
Arg Ala Leu Val Gly Leu Leu Leu Ala Thr Thr Leu Gly Leu Gly Val
25 30 35
gcg cag tgg att caa aaa gta gtg gca gaa gat cta ggc cag cat tat 259
Ala Gln Trp Ile Gln Lys Val Val Ala Glu Asp Leu Gly Gln His Tyr
40 45 50
gtg cat gag gtg cgt cgt gaa ttg gtg ggt gct gcg ctg gtg cct gga 307
Val His Glu Val Arg Arg Glu Leu Val Gly Ala Ala Leu Val Pro Gly
55 60 65
aat acg gcc tcg ttg ggc gtg act gtc acc cga gcc agc aat gat ctc 355
Asn Thr Ala Ser Leu Gly Val Thr Val Thr Arg Ala Ser Asn Asp Leu
70 75 80 85
acc gcg gtg cgc aat tgg gtg gct ttg ggc att gtt ccg atg gtc acc 403
Thr Ala Val Arg Asn Trp Val Ala Leu Gly Ile Val Pro Met Val Thr
90 95 100
ggg ctg ccg ttg att gcg att gtg ctg gtg gcg ttg ttt atc caa gat 451
Gly Leu Pro Leu Ile Ala Ile Val Leu Val Ala Leu Phe Ile Gln Asp
105 110 115
ctc cgc aca ggc gtg gct gtt act gtg cca ctg ctc atg tgt gta gcc 499
Leu Arg Thr Gly Val Ala Val Thr Val Pro Leu Leu Met Cys Val Ala
120 125 130
gtg ctg ccg gtg gtg gcg cgg tgg act ttg aaa aga gca cgt gaa cta 547
Val Leu Pro Val Val Ala Arg Trp Thr Leu Lys Arg Ala Arg Glu Leu
135 140 145
cgc aaa aaa cgt gga cgc atg gct gcg cgg atc gca gat tct gtc atg 595
Arg Lys Lys Arg Gly Arg Met Ala Ala Arg Ile Ala Asp Ser Val Met
150 155 160 165
gct gga gaa tta ctg cac gca aca gga gca ata gac cgt gag ctc aat 643
Ala Gly Glu Leu Leu His Ala Thr Gly Ala Ile Asp Arg Glu Leu Asn
170 175 180
gca gtc acc cga gat tcc gac cga gtg gtg ata gct gct gta aga cgt 691
Ala Val Thr Arg Asp Ser Asp Arg Val Val Ile Ala Ala Val Arg Arg
185 190 195
tcc tgg gcc acc ggt ttt agc cgc gca ttg atg gcc atg gca gcc tcg 739
Ser Trp Ala Thr Gly Phe Ser Arg Ala Leu Met Ala Met Ala Ala Ser
200 205 210
ctt ggc act gtc agc att gtg att tct ggc cac ctg gaa gta agt gag 787
Leu Gly Thr Val Ser Ile Val Ile Ser Gly His Leu Glu Val Ser Glu
215 220 225
gtt gcg gga ata atg atg ctt ctt ggc gtt ctt gcc act cca gtt gca 835
Val Ala Gly Ile Met Met Leu Leu Gly Val Leu Ala Thr Pro Val Ala
230 235 240 245
gaa ctt ggc cgc gtg gtg gaa tat cgc caa aat tat aaa gcc gcg aca 883
Glu Leu Gly Arg Val Val Glu Tyr Arg Gln Asn Tyr Lys Ala Ala Thr
250 255 260
cgc atc ctg att cca ctt ctg caa cga ggc tca gaa ttt aaa cac tcc 931
Arg Ile Leu Ile Pro Leu Leu Gln Arg Gly Ser Glu Phe Lys His Ser
265 270 275
caa caa aaa cta ccc ggg ttg caa gca aca gaa gga atc ccc ggt gtc 979
Gln Gln Lys Leu Pro Gly Leu Gln Ala Thr Glu Gly Ile Pro Gly Val
280 285 290
tat gtc aaa ggt att tcc gcc ctt cct gga gaa cgg atc tac ctc cac 1027
Tyr Val Lys Gly Ile Ser Ala Leu Pro Gly Glu Arg Ile Tyr Leu His
295 300 305
ggc tct gca gat gcg acg aga aaa tgg gtc acc tcg ttg tct gca atg 1075
Gly Ser Ala Asp Ala Thr Arg Lys Trp Val Thr Ser Leu Ser Ala Met
310 315 320 325
gag gaa ggc aca gat gta ata gtc aac ggt caa agg ctt tcg cag ctt 1123
Glu Glu Gly Thr Asp Val Ile Val Asn Gly Gln Arg Leu Ser Gln Leu
330 335 340
cct ttg aaa caa cga cgc gcc ctc atc gga atc gcc tca gca cac cac 1171
Pro Leu Lys Gln Arg Arg Ala Leu Ile Gly Ile Ala Ser Ala His His
345 350 355
cac tta agc cgt ggt tca gta tcg cgc ctg gtt ggt ttg cga gtg ccg 1219
His Leu Ser Arg Gly Ser Val Ser Arg Leu Val Gly Leu Arg Val Pro
360 365 370
gat gcc acc gtg gaa gaa att gag caa gca ctg gaa caa gtt ggt ctg 1267
Asp Ala Thr Val Glu Glu Ile Glu Gln Ala Leu Glu Gln Val Gly Leu
375 380 385
aac aac acc ggg aaa caa cgc ttg aaa aac ggc gga cac ccc tgg agt 1315
Asn Asn Thr Gly Lys Gln Arg Leu Lys Asn Gly Gly His Pro Trp Ser
390 395 400 405
act tcg cag atc aac aaa ctg aaa att gcc agc gcc acc ctt cga acc 1363
Thr Ser Gln Ile Asn Lys Leu Lys Ile Ala Ser Ala Thr Leu Arg Thr
410 415 420
cca ccg ctt ttg gta ctt gaa ggc atc acc cct gaa aac ctc ctc aac 1411
Pro Pro Leu Leu Val Leu Glu Gly Ile Thr Pro Glu Asn Leu Leu Asn
425 430 435
tat ccc gga gtg atc atc tcc acc gtt cag gag aac cca tcc gaa aca 1459
Tyr Pro Gly Val Ile Ile Ser Thr Val Gln Glu Asn Pro Ser Glu Thr
440 445 450
tgg cgg caa gtg aac atc taatctagaa acatggcagg acg 1500
Trp Arg Gln Val Asn Ile
455
<210> 302
<211> 459
<212> PRT
<213> Corynebacterium glutamicum
<400> 302
Val Leu Gln Ala Leu Leu Ala Ile Met Val Ser Leu Ser Val Ala Ala
1 5 10 15
Ile Leu Glu Gly Asn Arg Ala Leu Val Gly Leu Leu Leu Ala Thr Thr
20 25 30
Leu Gly Leu Gly Val Ala Gln Trp Ile Gln Lys Val Val Ala Glu Asp
35 40 45
Leu Gly Gln His Tyr Val His Glu Val Arg Arg Glu Leu Val Gly Ala
50 55 60
Ala Leu Val Pro Gly Asn Thr Ala Ser Leu Gly Val Thr Val Thr Arg
65 70 75 80
Ala Ser Asn Asp Leu Thr Ala Val Arg Asn Trp Val Ala Leu Gly Ile
85 90 95
Val Pro Met Val Thr Gly Leu Pro Leu Ile Ala Ile Val Leu Val Ala
100 105 110
Leu Phe Ile Gln Asp Leu Arg Thr Gly Val Ala Val Thr Val Pro Leu
115 120 125
Leu Met Cys Val Ala Val Leu Pro Val Val Ala Arg Trp Thr Leu Lys
130 135 140
Arg Ala Arg Glu Leu Arg Lys Lys Arg Gly Arg Met Ala Ala Arg Ile
145 150 155 160
Ala Asp Ser Val Met Ala Gly Glu Leu Leu His Ala Thr Gly Ala Ile
165 170 175
Asp Arg Glu Leu Asn Ala Val Thr Arg Asp Ser Asp Arg Val Val Ile
180 185 190
Ala Ala Val Arg Arg Ser Trp Ala Thr Gly Phe Ser Arg Ala Leu Met
195 200 205
Ala Met Ala Ala Ser Leu Gly Thr Val Ser Ile Val Ile Ser Gly His
210 215 220
Leu Glu Val Ser Glu Val Ala Gly Ile Met Met Leu Leu Gly Val Leu
225 230 235 240
Ala Thr Pro Val Ala Glu Leu Gly Arg Val Val Glu Tyr Arg Gln Asn
245 250 255
Tyr Lys Ala Ala Thr Arg Ile Leu Ile Pro Leu Leu Gln Arg Gly Ser
260 265 270
Glu Phe Lys His Ser Gln Gln Lys Leu Pro Gly Leu Gln Ala Thr Glu
275 280 285
Gly Ile Pro Gly Val Tyr Val Lys Gly Ile Ser Ala Leu Pro Gly Glu
290 295 300
Arg Ile Tyr Leu His Gly Ser Ala Asp Ala Thr Arg Lys Trp Val Thr
305 310 315 320
Ser Leu Ser Ala Met Glu Glu Gly Thr Asp Val Ile Val Asn Gly Gln
325 330 335
Arg Leu Ser Gln Leu Pro Leu Lys Gln Arg Arg Ala Leu Ile Gly Ile
340 345 350
Ala Ser Ala His His His Leu Ser Arg Gly Ser Val Ser Arg Leu Val
355 360 365
Gly Leu Arg Val Pro Asp Ala Thr Val Glu Glu Ile Glu Gln Ala Leu
370 375 380
Glu Gln Val Gly Leu Asn Asn Thr Gly Lys Gln Arg Leu Lys Asn Gly
385 390 395 400
Gly His Pro Trp Ser Thr Ser Gln Ile Asn Lys Leu Lys Ile Ala Ser
405 410 415
Ala Thr Leu Arg Thr Pro Pro Leu Leu Val Leu Glu Gly Ile Thr Pro
420 425 430
Glu Asn Leu Leu Asn Tyr Pro Gly Val Ile Ile Ser Thr Val Gln Glu
435 440 445
Asn Pro Ser Glu Thr Trp Arg Gln Val Asn Ile
450 455
<210> 303
<211> 412
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(412)
<223> FRXA00456
<400> 303
ctcaccaacc cggagatcgt cacagcggtg ctaacggatc atgcctagct tatggcgtgc 60
tcgtcgcaga cttttgctca ttgccctagg tgtacttggt gtg ctg cag gca ctg 115
Val Leu Gln Ala Leu
1 5
ctg gcg atc atg gtg tcg ttg agc gta gcc gcc ata ctt gag gga aac 163
Leu Ala Ile Met Val Ser Leu Ser Val Ala Ala Ile Leu Glu Gly Asn
10 15 20
cga gca ctt gtt gga ttg ctg ctt gct acc acg ttg ggt ttg ggg gtg 211
Arg Ala Leu Val Gly Leu Leu Leu Ala Thr Thr Leu Gly Leu Gly Val
25 30 35
gcg cag tgg att caa aaa gta gtg gca gaa gat cta ggc cag cat tat 259
Ala Gln Trp Ile Gln Lys Val Val Ala Glu Asp Leu Gly Gln His Tyr
40 45 50
gtg cat gag gtg cgt cgt gaa ttg gtg ggt gct gcg ctg gtg cct gga 307
Val His Glu Val Arg Arg Glu Leu Val Gly Ala Ala Leu Val Pro Gly
55 60 65
aat acg gcc tcg ttg ggc gtg act gtc acc cga gcc agc aat gat ctc 355
Asn Thr Ala Ser Leu Gly Val Thr Val Thr Arg Ala Ser Asn Asp Leu
70 75 80 85
acc gcg gtg cgc aat tgg gtg gct ttg ggc att gtt ccg atg gtc acc 403
Thr Ala Val Arg Asn Trp Val Ala Leu Gly Ile Val Pro Met Val Thr
90 95 100
ggg ctg ccg 412
Gly Leu Pro
<210> 304
<211> 104
<212> PRT
<213> Corynebacterium glutamicum
<400> 304
Val Leu Gln Ala Leu Leu Ala Ile Met Val Ser Leu Ser Val Ala Ala
1 5 10 15
Ile Leu Glu Gly Asn Arg Ala Leu Val Gly Leu Leu Leu Ala Thr Thr
20 25 30
Leu Gly Leu Gly Val Ala Gln Trp Ile Gln Lys Val Val Ala Glu Asp
35 40 45
Leu Gly Gln His Tyr Val His Glu Val Arg Arg Glu Leu Val Gly Ala
50 55 60
Ala Leu Val Pro Gly Asn Thr Ala Ser Leu Gly Val Thr Val Thr Arg
65 70 75 80
Ala Ser Asn Asp Leu Thr Ala Val Arg Asn Trp Val Ala Leu Gly Ile
85 90 95
Val Pro Met Val Thr Gly Leu Pro
100
<210> 305
<211> 1040
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (31)..(1017)
<223> FRXA00459
<400> 305
aggcgtggct gttactgtgc cactgctcat gtg tgt acc cgt gct gcc ggt ggt 54
Val Cys Thr Arg Ala Ala Gly Gly
1 5
ggc gcg gtg act ttg aaa aga gca cgt gaa cta cgc aaa aaa cgt gga 102
Gly Ala Val Thr Leu Lys Arg Ala Arg Glu Leu Arg Lys Lys Arg Gly
10 15 20
cgc atg gct gcg cgg atc gca gat tct gtc atg gct gga gaa tta ctg 150
Arg Met Ala Ala Arg Ile Ala Asp Ser Val Met Ala Gly Glu Leu Leu
25 30 35 40
cac gca aca gga gca ata gac cgt gag ctc aat gca gtc acc cga gat 198
His Ala Thr Gly Ala Ile Asp Arg Glu Leu Asn Ala Val Thr Arg Asp
45 50 55
tcc gac cga gtg gtg ata gct gct gta aga cgt tcc tgg gcc acc ggt 246
Ser Asp Arg Val Val Ile Ala Ala Val Arg Arg Ser Trp Ala Thr Gly
60 65 70
ttt agc cgc gca ttg atg gcc atg gca gcc tcg ctt ggc act gtc agc 294
Phe Ser Arg Ala Leu Met Ala Met Ala Ala Ser Leu Gly Thr Val Ser
75 80 85
att gtg att tct ggc cac ctg gaa gta agt gag gtt gcg gga ata atg 342
Ile Val Ile Ser Gly His Leu Glu Val Ser Glu Val Ala Gly Ile Met
90 95 100
atg ctt ctt ggc gtt ctt gcc act cca gtt gca gaa ctt ggc cgc gtg 390
Met Leu Leu Gly Val Leu Ala Thr Pro Val Ala Glu Leu Gly Arg Val
105 110 115 120
gtg gaa tat cgc caa aat tat aaa gcc gcg aca cgc atc ctg att cca 438
Val Glu Tyr Arg Gln Asn Tyr Lys Ala Ala Thr Arg Ile Leu Ile Pro
125 130 135
ctt ctg caa cga ggc tca gaa ttt aaa cac tcc caa caa aaa cta ccc 486
Leu Leu Gln Arg Gly Ser Glu Phe Lys His Ser Gln Gln Lys Leu Pro
140 145 150
ggg ttg caa gca aca gaa gga atc ccc ggt gtc tat gtc aaa ggt att 534
Gly Leu Gln Ala Thr Glu Gly Ile Pro Gly Val Tyr Val Lys Gly Ile
155 160 165
tcc gcc ctt cct gga gaa cgg atc tac ctc cac ggc tct gca gat gcg 582
Ser Ala Leu Pro Gly Glu Arg Ile Tyr Leu His Gly Ser Ala Asp Ala
170 175 180
acg aga aaa tgg gtc acc tcg ttg tct gca atg gag gaa ggc aca gat 630
Thr Arg Lys Trp Val Thr Ser Leu Ser Ala Met Glu Glu Gly Thr Asp
185 190 195 200
gta ata gtc aac ggt caa agg ctt tcg cag ctt cct ttg aaa caa cga 678
Val Ile Val Asn Gly Gln Arg Leu Ser Gln Leu Pro Leu Lys Gln Arg
205 210 215
cgc gcc ctc atc gga atc gcc tca gca cac cac cac tta agc cgt ggt 726
Arg Ala Leu Ile Gly Ile Ala Ser Ala His His His Leu Ser Arg Gly
220 225 230
tca gta tcg cgc ctg gtt ggt ttg cga gtg ccg gat gcc acc gtg gaa 774
Ser Val Ser Arg Leu Val Gly Leu Arg Val Pro Asp Ala Thr Val Glu
235 240 245
gaa att gag caa gca ctg gaa caa gtt ggt ctg aac aac acc ggg aaa 822
Glu Ile Glu Gln Ala Leu Glu Gln Val Gly Leu Asn Asn Thr Gly Lys
250 255 260
caa cgc ttg aaa aac ggc gga cac ccc tgg agt act tcg cag atc aac 870
Gln Arg Leu Lys Asn Gly Gly His Pro Trp Ser Thr Ser Gln Ile Asn
265 270 275 280
aaa ctg aaa att gcc agc gcc acc ctt cga acc cca ccg ctt ttg gta 918
Lys Leu Lys Ile Ala Ser Ala Thr Leu Arg Thr Pro Pro Leu Leu Val
285 290 295
ctt gaa ggc atc acc cct gaa aac ctc ctc aac tat ccc gga gtg atc 966
Leu Glu Gly Ile Thr Pro Glu Asn Leu Leu Asn Tyr Pro Gly Val Ile
300 305 310
atc tcc acc gtt cag gag aac cca tcc gaa aca tgg cgg caa gtg aac 1014
Ile Ser Thr Val Gln Glu Asn Pro Ser Glu Thr Trp Arg Gln Val Asn
315 320 325
atc taatctagaa acatggcagg acg 1040
Ile
<210> 306
<211> 329
<212> PRT
<213> Corynebacterium glutamicum
<400> 306
Val Cys Thr Arg Ala Ala Gly Gly Gly Ala Val Thr Leu Lys Arg Ala
1 5 10 15
Arg Glu Leu Arg Lys Lys Arg Gly Arg Met Ala Ala Arg Ile Ala Asp
20 25 30
Ser Val Met Ala Gly Glu Leu Leu His Ala Thr Gly Ala Ile Asp Arg
35 40 45
Glu Leu Asn Ala Val Thr Arg Asp Ser Asp Arg Val Val Ile Ala Ala
50 55 60
Val Arg Arg Ser Trp Ala Thr Gly Phe Ser Arg Ala Leu Met Ala Met
65 70 75 80
Ala Ala Ser Leu Gly Thr Val Ser Ile Val Ile Ser Gly His Leu Glu
85 90 95
Val Ser Glu Val Ala Gly Ile Met Met Leu Leu Gly Val Leu Ala Thr
100 105 110
Pro Val Ala Glu Leu Gly Arg Val Val Glu Tyr Arg Gln Asn Tyr Lys
115 120 125
Ala Ala Thr Arg Ile Leu Ile Pro Leu Leu Gln Arg Gly Ser Glu Phe
130 135 140
Lys His Ser Gln Gln Lys Leu Pro Gly Leu Gln Ala Thr Glu Gly Ile
145 150 155 160
Pro Gly Val Tyr Val Lys Gly Ile Ser Ala Leu Pro Gly Glu Arg Ile
165 170 175
Tyr Leu His Gly Ser Ala Asp Ala Thr Arg Lys Trp Val Thr Ser Leu
180 185 190
Ser Ala Met Glu Glu Gly Thr Asp Val Ile Val Asn Gly Gln Arg Leu
195 200 205
Ser Gln Leu Pro Leu Lys Gln Arg Arg Ala Leu Ile Gly Ile Ala Ser
210 215 220
Ala His His His Leu Ser Arg Gly Ser Val Ser Arg Leu Val Gly Leu
225 230 235 240
Arg Val Pro Asp Ala Thr Val Glu Glu Ile Glu Gln Ala Leu Glu Gln
245 250 255
Val Gly Leu Asn Asn Thr Gly Lys Gln Arg Leu Lys Asn Gly Gly His
260 265 270
Pro Trp Ser Thr Ser Gln Ile Asn Lys Leu Lys Ile Ala Ser Ala Thr
275 280 285
Leu Arg Thr Pro Pro Leu Leu Val Leu Glu Gly Ile Thr Pro Glu Asn
290 295 300
Leu Leu Asn Tyr Pro Gly Val Ile Ile Ser Thr Val Gln Glu Asn Pro
305 310 315 320
Ser Glu Thr Trp Arg Gln Val Asn Ile
325
<210> 307
<211> 771
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(748)
<223> RXN01604
<400> 307
ctctcatgtt gttgtcctct agttgacagc gggggtggtg gtggtcctaa aatagcctac 60
gataactgat agtgtttcct ccacttacgg aagaagatac atg aat acc cct ctt 115
Met Asn Thr Pro Leu
1 5
ttg aga agc tct ggg ctc tcc atc cgc gac aca ccc ttc gcc gat gtt 163
Leu Arg Ser Ser Gly Leu Ser Ile Arg Asp Thr Pro Phe Ala Asp Val
10 15 20
gag ata gct cca gac agc gga ctc act ttg ctg agc acc ggg cgc gaa 211
Glu Ile Ala Pro Asp Ser Gly Leu Thr Leu Leu Ser Thr Gly Arg Glu
25 30 35
tcc caa tcc agt tcc ttt tct ttg gta ctt tcc ggc cgc atg cgc gcc 259
Ser Gln Ser Ser Ser Phe Ser Leu Val Leu Ser Gly Arg Met Arg Ala
40 45 50
tcc acc gga acc atc gaa tta aac ggc gaa ccc atc aag gca acc aag 307
Ser Thr Gly Thr Ile Glu Leu Asn Gly Glu Pro Ile Lys Ala Thr Lys
55 60 65
ctg gcc aag cat gtg gct ttg gcg ggc atc cct gaa atc gat tca ctc 355
Leu Ala Lys His Val Ala Leu Ala Gly Ile Pro Glu Ile Asp Ser Leu
70 75 80 85
gag cga ctt gtc act gtg cgc acc gtt gtc cgt gaa caa ctc gcc tgg 403
Glu Arg Leu Val Thr Val Arg Thr Val Val Arg Glu Gln Leu Ala Trp
90 95 100
tca agc cct tgg tac ctg atg gtg ccc agg gat att agt gat tcg gga 451
Ser Ser Pro Trp Tyr Leu Met Val Pro Arg Asp Ile Ser Asp Ser Gly
105 110 115
cgg tgg gtt gac gtc gaa aag cat ctt ggc ctg aac ctg aac cct aaa 499
Arg Trp Val Asp Val Glu Lys His Leu Gly Leu Asn Leu Asn Pro Lys
120 125 130
acc tta atc ggc gac ctc agc gtg ctc gag cgt ttt aag ctg cgc atc 547
Thr Leu Ile Gly Asp Leu Ser Val Leu Glu Arg Phe Lys Leu Arg Ile
135 140 145
gcg ctg gcg ctg ctg gcg cgg cca gag gcg caa ctg ttg gtc gtg gat 595
Ala Leu Ala Leu Leu Ala Arg Pro Glu Ala Gln Leu Leu Val Val Asp
150 155 160 165
gat ccc gat caa gtg cgc agc atg gaa ttg cgt gcg gag gtg ttg cac 643
Asp Pro Asp Gln Val Arg Ser Met Glu Leu Arg Ala Glu Val Leu His
170 175 180
gca ttg aaa ggc gtt gca gag gat ctc cct gtg gtc gtg gta tcc acc 691
Ala Leu Lys Gly Val Ala Glu Asp Leu Pro Val Val Val Val Ser Thr
185 190 195
aac cca gat ttt gat tcc ttg gcc gat acc gct ttg acc att acg ggg 739
Asn Pro Asp Phe Asp Ser Leu Ala Asp Thr Ala Leu Thr Ile Thr Gly
200 205 210
gct gga aac taatggcatt tttacacttt ggc 771
Ala Gly Asn
215
<210> 308
<211> 216
<212> PRT
<213> Corynebacterium glutamicum
<400> 308
Met Asn Thr Pro Leu Leu Arg Ser Ser Gly Leu Ser Ile Arg Asp Thr
1 5 10 15
Pro Phe Ala Asp Val Glu Ile Ala Pro Asp Ser Gly Leu Thr Leu Leu
20 25 30
Ser Thr Gly Arg Glu Ser Gln Ser Ser Ser Phe Ser Leu Val Leu Ser
35 40 45
Gly Arg Met Arg Ala Ser Thr Gly Thr Ile Glu Leu Asn Gly Glu Pro
50 55 60
Ile Lys Ala Thr Lys Leu Ala Lys His Val Ala Leu Ala Gly Ile Pro
65 70 75 80
Glu Ile Asp Ser Leu Glu Arg Leu Val Thr Val Arg Thr Val Val Arg
85 90 95
Glu Gln Leu Ala Trp Ser Ser Pro Trp Tyr Leu Met Val Pro Arg Asp
100 105 110
Ile Ser Asp Ser Gly Arg Trp Val Asp Val Glu Lys His Leu Gly Leu
115 120 125
Asn Leu Asn Pro Lys Thr Leu Ile Gly Asp Leu Ser Val Leu Glu Arg
130 135 140
Phe Lys Leu Arg Ile Ala Leu Ala Leu Leu Ala Arg Pro Glu Ala Gln
145 150 155 160
Leu Leu Val Val Asp Asp Pro Asp Gln Val Arg Ser Met Glu Leu Arg
165 170 175
Ala Glu Val Leu His Ala Leu Lys Gly Val Ala Glu Asp Leu Pro Val
180 185 190
Val Val Val Ser Thr Asn Pro Asp Phe Asp Ser Leu Ala Asp Thr Ala
195 200 205
Leu Thr Ile Thr Gly Ala Gly Asn
210 215
<210> 309
<211> 629
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(606)
<223> FRXA01604
<400> 309
gac aca ccc ttc gcc gat gtt gag ata gct cca gac agc gga ctc act 48
Asp Thr Pro Phe Ala Asp Val Glu Ile Ala Pro Asp Ser Gly Leu Thr
1 5 10 15
ttg ctg agc acc ggg cgc gaa tcc caa tcc agt tcc ttt tct ttg gta 96
Leu Leu Ser Thr Gly Arg Glu Ser Gln Ser Ser Ser Phe Ser Leu Val
20 25 30
ctt tcc ggc cgc atg cgc gcc tcc acc gga acc atc gaa tta aac ggc 144
Leu Ser Gly Arg Met Arg Ala Ser Thr Gly Thr Ile Glu Leu Asn Gly
35 40 45
gaa ccc atc aag gca acc aag ctg gcc aag cat gtg gct ttg gcg ggc 192
Glu Pro Ile Lys Ala Thr Lys Leu Ala Lys His Val Ala Leu Ala Gly
50 55 60
atc cct gaa atc gat tca ctc gag cga ctt gtc act gtg cgc acc gtt 240
Ile Pro Glu Ile Asp Ser Leu Glu Arg Leu Val Thr Val Arg Thr Val
65 70 75 80
gtc cgt gaa caa ctc gcc tgg tca agc cct tgg tac ctg atg gtg ccc 288
Val Arg Glu Gln Leu Ala Trp Ser Ser Pro Trp Tyr Leu Met Val Pro
85 90 95
agg gat att agt gat tcg gga cgg tgg gtt gac gtc gaa aag cat ctt 336
Arg Asp Ile Ser Asp Ser Gly Arg Trp Val Asp Val Glu Lys His Leu
100 105 110
ggc ctg aac ctg aac cct aaa acc tta atc ggc gac ctc agc gtg ctc 384
Gly Leu Asn Leu Asn Pro Lys Thr Leu Ile Gly Asp Leu Ser Val Leu
115 120 125
gag cgt ttt aag ctg cgc atc gcg ctg gcg ctg ctg gcg cgg cca gag 432
Glu Arg Phe Lys Leu Arg Ile Ala Leu Ala Leu Leu Ala Arg Pro Glu
130 135 140
gcg caa ctg ttg gtc gtg gat gat ccc gat caa gtg cgc agc atg gaa 480
Ala Gln Leu Leu Val Val Asp Asp Pro Asp Gln Val Arg Ser Met Glu
145 150 155 160
ttg cgt gcg gag gtg ttg cac gca ttg aaa ggc gtt gca gag gat ctc 528
Leu Arg Ala Glu Val Leu His Ala Leu Lys Gly Val Ala Glu Asp Leu
165 170 175
cct gtg gtc gtg gta tcc acc aac cca gat ttt gat tcc ttg gcc gat 576
Pro Val Val Val Val Ser Thr Asn Pro Asp Phe Asp Ser Leu Ala Asp
180 185 190
acc gct ttg acc att acg ggg gct gga aac taatggcatt tttacacttt 626
Thr Ala Leu Thr Ile Thr Gly Ala Gly Asn
195 200
ggc 629
<210> 310
<211> 202
<212> PRT
<213> Corynebacterium glutamicum
<400> 310
Asp Thr Pro Phe Ala Asp Val Glu Ile Ala Pro Asp Ser Gly Leu Thr
1 5 10 15
Leu Leu Ser Thr Gly Arg Glu Ser Gln Ser Ser Ser Phe Ser Leu Val
20 25 30
Leu Ser Gly Arg Met Arg Ala Ser Thr Gly Thr Ile Glu Leu Asn Gly
35 40 45
Glu Pro Ile Lys Ala Thr Lys Leu Ala Lys His Val Ala Leu Ala Gly
50 55 60
Ile Pro Glu Ile Asp Ser Leu Glu Arg Leu Val Thr Val Arg Thr Val
65 70 75 80
Val Arg Glu Gln Leu Ala Trp Ser Ser Pro Trp Tyr Leu Met Val Pro
85 90 95
Arg Asp Ile Ser Asp Ser Gly Arg Trp Val Asp Val Glu Lys His Leu
100 105 110
Gly Leu Asn Leu Asn Pro Lys Thr Leu Ile Gly Asp Leu Ser Val Leu
115 120 125
Glu Arg Phe Lys Leu Arg Ile Ala Leu Ala Leu Leu Ala Arg Pro Glu
130 135 140
Ala Gln Leu Leu Val Val Asp Asp Pro Asp Gln Val Arg Ser Met Glu
145 150 155 160
Leu Arg Ala Glu Val Leu His Ala Leu Lys Gly Val Ala Glu Asp Leu
165 170 175
Pro Val Val Val Val Ser Thr Asn Pro Asp Phe Asp Ser Leu Ala Asp
180 185 190
Thr Ala Leu Thr Ile Thr Gly Ala Gly Asn
195 200
<210> 311
<211> 2262
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(2239)
<223> RXN02547
<400> 311
ggggccgtcg ataagcgaag aacaattagc actgcgcgcg ctggtctgac gcattggtta 60
aggggctggc ggtccggcgc cggaatcggc ggaggagctt ttg gag ctc aac aac 115
Leu Glu Leu Asn Asn
1 5
gct gcg cgg ctg acc gtg gat gag tat ccg gcg gcg agg gaa gcg ctt 163
Ala Ala Arg Leu Thr Val Asp Glu Tyr Pro Ala Ala Arg Glu Ala Leu
10 15 20
gaa tct gca ggt cag agg aat gta gag gac cga acc cgt gcg gtt gat 211
Glu Ser Ala Gly Gln Arg Asn Val Glu Asp Arg Thr Arg Ala Val Asp
25 30 35
gag ttc aaa gcg gcg gat caa gag ctg tct tct ttg agt aaa ggc agc 259
Glu Phe Lys Ala Ala Asp Gln Glu Leu Ser Ser Leu Ser Lys Gly Ser
40 45 50
agt aat att gag tac cgt ttg ctg cag gtg cgg gaa aat ttg tgt cag 307
Ser Asn Ile Glu Tyr Arg Leu Leu Gln Val Arg Glu Asn Leu Cys Gln
55 60 65
gat ttg ggc gtg agc ccg cgg gat atg ccc ttt gcc ggt gag ctg att 355
Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe Ala Gly Glu Leu Ile
70 75 80 85
gat ccg aat aat gcg gaa tgg gaa ccc gtt gtg cag cgc att ttg ggt 403
Asp Pro Asn Asn Ala Glu Trp Glu Pro Val Val Gln Arg Ile Leu Gly
90 95 100
ggt ttt gct gcg gaa atg ttg gtt cct cat ggg ttg ttg cca cgg gtt 451
Gly Phe Ala Ala Glu Met Leu Val Pro His Gly Leu Leu Pro Arg Val
105 110 115
cgg gat tgg gta aat gcc aaa cat ttg gca gcg ctg ctg aaa ttc aac 499
Arg Asp Trp Val Asn Ala Lys His Leu Ala Ala Leu Leu Lys Phe Asn
120 125 130
ggc gtg gtg aca acg ggg gag tac aaa acc tcg cgt ttt ccg gcg gat 547
Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser Arg Phe Pro Ala Asp
135 140 145
tcc ctg atc cga aaa gtt gat gtt gtg gag tcg ccg ttt cgc gat tgg 595
Ser Leu Ile Arg Lys Val Asp Val Val Glu Ser Pro Phe Arg Asp Trp
150 155 160 165
gta aat caa gaa tta ggc aag cgt ttt aat att cgg tgc gtg cgc act 643
Val Asn Gln Glu Leu Gly Lys Arg Phe Asn Ile Arg Cys Val Arg Thr
170 175 180
cct gag gaa ttg tcg gcg ctg ggg cca cgc gat cag ggc gtg acc att 691
Pro Glu Glu Leu Ser Ala Leu Gly Pro Arg Asp Gln Gly Val Thr Ile
185 190 195
ttg ggt gtg cga aaa ttt gcg cag cag aca ggc gat ccg acg acg cgt 739
Leu Gly Val Arg Lys Phe Ala Gln Gln Thr Gly Asp Pro Thr Thr Arg
200 205 210
tgg gaa aaa gat gat cgc cga aag ctg ggg gat cgt tcc aca tac cgt 787
Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp Arg Ser Thr Tyr Arg
215 220 225
ttg ggt tcc acc aat gat gcc aag gtg gaa acg ctt cgg gaa acc gtg 835
Leu Gly Ser Thr Asn Asp Ala Lys Val Glu Thr Leu Arg Glu Thr Val
230 235 240 245
aaa gct ggc aaa gca gtt gtg cag gca gct gat aat cgc att gct gca 883
Lys Ala Gly Lys Ala Val Val Gln Ala Ala Asp Asn Arg Ile Ala Ala
250 255 260
aac cgc gct gag ctg cgg gaa ctt gaa cgg cag tat caa gct tcg caa 931
Asn Arg Ala Glu Leu Arg Glu Leu Glu Arg Gln Tyr Gln Ala Ser Gln
265 270 275
gaa att ttg aaa gtg tcg tgg gct cag att gat gtg gaa tca gcc gac 979
Glu Ile Leu Lys Val Ser Trp Ala Gln Ile Asp Val Glu Ser Ala Asp
280 285 290
gcg gcg att gct gag ctg gac cga ttg ctg gaa gag ctg aac aac act 1027
Ala Ala Ile Ala Glu Leu Asp Arg Leu Leu Glu Glu Leu Asn Asn Thr
295 300 305
cca gag gcc acc gag ctt tcc gcg cgg cat gag gcg gcg aag cag acg 1075
Pro Glu Ala Thr Glu Leu Ser Ala Arg His Glu Ala Ala Lys Gln Thr
310 315 320 325
ctc gcg agg gtt tct gac ttg ctt gtc gca gct cag agt gag gaa acc 1123
Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala Gln Ser Glu Glu Thr
330 335 340
gtg gcg tcg atg aac ctg aaa cgc gcc gaa act gaa ttg aaa cgg ctc 1171
Val Ala Ser Met Asn Leu Lys Arg Ala Glu Thr Glu Leu Lys Arg Leu
345 350 355
gaa agc ctg ccg gtt gcg gag gtt tct gaa gaa atc gcg cgg gaa gtg 1219
Glu Ser Leu Pro Val Ala Glu Val Ser Glu Glu Ile Ala Arg Glu Val
360 365 370
gag aaa cta ttt ctt gcc aac acc cgc cgg gtt cac gcc gcc aac gtg 1267
Glu Lys Leu Phe Leu Ala Asn Thr Arg Arg Val His Ala Ala Asn Val
375 380 385
gat gag cag acc att gcg ctg cgc gag gat ctg gac aaa caa atc gat 1315
Asp Glu Gln Thr Ile Ala Leu Arg Glu Asp Leu Asp Lys Gln Ile Asp
390 395 400 405
gcc aat gag gca gaa ctt cga cgt tgt gaa aac caa att gtt ggc att 1363
Ala Asn Glu Ala Glu Leu Arg Arg Cys Glu Asn Gln Ile Val Gly Ile
410 415 420
ttg cgc agc tat att gaa acg tgg cct gcg aac cgc gct gac tta caa 1411
Leu Arg Ser Tyr Ile Glu Thr Trp Pro Ala Asn Arg Ala Asp Leu Gln
425 430 435
gcc gaa cct gag ttt gtt ggt gag gcc atc aac cgc ctc ggc gag ctt 1459
Ala Glu Pro Glu Phe Val Gly Glu Ala Ile Asn Arg Leu Gly Glu Leu
440 445 450
cgc agc gat cgt ttg gca gaa ttc acg gcc aaa ttc cta ggg ctc atg 1507
Arg Ser Asp Arg Leu Ala Glu Phe Thr Ala Lys Phe Leu Gly Leu Met
455 460 465
aac gag atg tcc acc cga aac ctc ggc caa atc tcg cgg cgt cta cgt 1555
Asn Glu Met Ser Thr Arg Asn Leu Gly Gln Ile Ser Arg Arg Leu Arg
470 475 480 485
gat gcg cgc cgg gaa atc gag gag cgc atc gag ccg atc aac gcc tcc 1603
Asp Ala Arg Arg Glu Ile Glu Glu Arg Ile Glu Pro Ile Asn Ala Ser
490 495 500
ttg gcg cag tcg gaa ttc aac gaa ggt cgc ttc ctg cac atc gac atc 1651
Leu Ala Gln Ser Glu Phe Asn Glu Gly Arg Phe Leu His Ile Asp Ile
505 510 515
cgt gat caa agt ggt ccg att gtg agg gaa ttc cag cag aaa ctt gat 1699
Arg Asp Gln Ser Gly Pro Ile Val Arg Glu Phe Gln Gln Lys Leu Asp
520 525 530
gcc gct acc agc ggt gac ctg gga acc agt acc gag aaa caa gcc ttc 1747
Ala Ala Thr Ser Gly Asp Leu Gly Thr Ser Thr Glu Lys Gln Ala Phe
535 540 545
gcc cgt tat gcg ctg atc gct gaa atc att tcc aaa ctc gcc tcc cac 1795
Ala Arg Tyr Ala Leu Ile Ala Glu Ile Ile Ser Lys Leu Ala Ser His
550 555 560 565
gac tcc gcc gac gcc cgc tgg cgc aac acc gtt cta gac acc cgc cgc 1843
Asp Ser Ala Asp Ala Arg Trp Arg Asn Thr Val Leu Asp Thr Arg Arg
570 575 580
cac gtt cgc ttc atc ggc ctc gag cgc gat tcc gac ggc gca acc gtc 1891
His Val Arg Phe Ile Gly Leu Glu Arg Asp Ser Asp Gly Ala Thr Val
585 590 595
aac acc tac gtc gac tcc gca tca ctt tca ggc gga caa gcc cag aag 1939
Asn Thr Tyr Val Asp Ser Ala Ser Leu Ser Gly Gly Gln Ala Gln Lys
600 605 610
ctg gtg ttt ttc tgc ctc gcc gct gcc ttg cgc tac cag cta gcc gaa 1987
Leu Val Phe Phe Cys Leu Ala Ala Ala Leu Arg Tyr Gln Leu Ala Glu
615 620 625
ccc ggc gcc cat tat ccc acc tac gcc acc gtc att ctg gac gaa gcc 2035
Pro Gly Ala His Tyr Pro Thr Tyr Ala Thr Val Ile Leu Asp Glu Ala
630 635 640 645
ttc gac cgc gcc gac ccc gcc ttc acc cgc caa acc atg aac gtc ttc 2083
Phe Asp Arg Ala Asp Pro Ala Phe Thr Arg Gln Thr Met Asn Val Phe
650 655 660
cac agc ttc ggc ttc cac atg gtg ctc gcg acc ccg ctg aaa ctt atc 2131
His Ser Phe Gly Phe His Met Val Leu Ala Thr Pro Leu Lys Leu Ile
665 670 675
caa acc ctc ggc gat tat gtc ggc tcc acc atc gtg gtc agc tac acc 2179
Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr Ile Val Val Ser Tyr Thr
680 685 690
gaa aaa cca aac gcc cag ggc gca att cag ggc aat tcc agt ttc tct 2227
Glu Lys Pro Asn Ala Gln Gly Ala Ile Gln Gly Asn Ser Ser Phe Ser
695 700 705
agg atc gag aaa taacatgcca ttgtttatcg acg 2262
Arg Ile Glu Lys
710
<210> 312
<211> 713
<212> PRT
<213> Corynebacterium glutamicum
<400> 312
Leu Glu Leu Asn Asn Ala Ala Arg Leu Thr Val Asp Glu Tyr Pro Ala
1 5 10 15
Ala Arg Glu Ala Leu Glu Ser Ala Gly Gln Arg Asn Val Glu Asp Arg
20 25 30
Thr Arg Ala Val Asp Glu Phe Lys Ala Ala Asp Gln Glu Leu Ser Ser
35 40 45
Leu Ser Lys Gly Ser Ser Asn Ile Glu Tyr Arg Leu Leu Gln Val Arg
50 55 60
Glu Asn Leu Cys Gln Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe
65 70 75 80
Ala Gly Glu Leu Ile Asp Pro Asn Asn Ala Glu Trp Glu Pro Val Val
85 90 95
Gln Arg Ile Leu Gly Gly Phe Ala Ala Glu Met Leu Val Pro His Gly
100 105 110
Leu Leu Pro Arg Val Arg Asp Trp Val Asn Ala Lys His Leu Ala Ala
115 120 125
Leu Leu Lys Phe Asn Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser
130 135 140
Arg Phe Pro Ala Asp Ser Leu Ile Arg Lys Val Asp Val Val Glu Ser
145 150 155 160
Pro Phe Arg Asp Trp Val Asn Gln Glu Leu Gly Lys Arg Phe Asn Ile
165 170 175
Arg Cys Val Arg Thr Pro Glu Glu Leu Ser Ala Leu Gly Pro Arg Asp
180 185 190
Gln Gly Val Thr Ile Leu Gly Val Arg Lys Phe Ala Gln Gln Thr Gly
195 200 205
Asp Pro Thr Thr Arg Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp
210 215 220
Arg Ser Thr Tyr Arg Leu Gly Ser Thr Asn Asp Ala Lys Val Glu Thr
225 230 235 240
Leu Arg Glu Thr Val Lys Ala Gly Lys Ala Val Val Gln Ala Ala Asp
245 250 255
Asn Arg Ile Ala Ala Asn Arg Ala Glu Leu Arg Glu Leu Glu Arg Gln
260 265 270
Tyr Gln Ala Ser Gln Glu Ile Leu Lys Val Ser Trp Ala Gln Ile Asp
275 280 285
Val Glu Ser Ala Asp Ala Ala Ile Ala Glu Leu Asp Arg Leu Leu Glu
290 295 300
Glu Leu Asn Asn Thr Pro Glu Ala Thr Glu Leu Ser Ala Arg His Glu
305 310 315 320
Ala Ala Lys Gln Thr Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala
325 330 335
Gln Ser Glu Glu Thr Val Ala Ser Met Asn Leu Lys Arg Ala Glu Thr
340 345 350
Glu Leu Lys Arg Leu Glu Ser Leu Pro Val Ala Glu Val Ser Glu Glu
355 360 365
Ile Ala Arg Glu Val Glu Lys Leu Phe Leu Ala Asn Thr Arg Arg Val
370 375 380
His Ala Ala Asn Val Asp Glu Gln Thr Ile Ala Leu Arg Glu Asp Leu
385 390 395 400
Asp Lys Gln Ile Asp Ala Asn Glu Ala Glu Leu Arg Arg Cys Glu Asn
405 410 415
Gln Ile Val Gly Ile Leu Arg Ser Tyr Ile Glu Thr Trp Pro Ala Asn
420 425 430
Arg Ala Asp Leu Gln Ala Glu Pro Glu Phe Val Gly Glu Ala Ile Asn
435 440 445
Arg Leu Gly Glu Leu Arg Ser Asp Arg Leu Ala Glu Phe Thr Ala Lys
450 455 460
Phe Leu Gly Leu Met Asn Glu Met Ser Thr Arg Asn Leu Gly Gln Ile
465 470 475 480
Ser Arg Arg Leu Arg Asp Ala Arg Arg Glu Ile Glu Glu Arg Ile Glu
485 490 495
Pro Ile Asn Ala Ser Leu Ala Gln Ser Glu Phe Asn Glu Gly Arg Phe
500 505 510
Leu His Ile Asp Ile Arg Asp Gln Ser Gly Pro Ile Val Arg Glu Phe
515 520 525
Gln Gln Lys Leu Asp Ala Ala Thr Ser Gly Asp Leu Gly Thr Ser Thr
530 535 540
Glu Lys Gln Ala Phe Ala Arg Tyr Ala Leu Ile Ala Glu Ile Ile Ser
545 550 555 560
Lys Leu Ala Ser His Asp Ser Ala Asp Ala Arg Trp Arg Asn Thr Val
565 570 575
Leu Asp Thr Arg Arg His Val Arg Phe Ile Gly Leu Glu Arg Asp Ser
580 585 590
Asp Gly Ala Thr Val Asn Thr Tyr Val Asp Ser Ala Ser Leu Ser Gly
595 600 605
Gly Gln Ala Gln Lys Leu Val Phe Phe Cys Leu Ala Ala Ala Leu Arg
610 615 620
Tyr Gln Leu Ala Glu Pro Gly Ala His Tyr Pro Thr Tyr Ala Thr Val
625 630 635 640
Ile Leu Asp Glu Ala Phe Asp Arg Ala Asp Pro Ala Phe Thr Arg Gln
645 650 655
Thr Met Asn Val Phe His Ser Phe Gly Phe His Met Val Leu Ala Thr
660 665 670
Pro Leu Lys Leu Ile Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr Ile
675 680 685
Val Val Ser Tyr Thr Glu Lys Pro Asn Ala Gln Gly Ala Ile Gln Gly
690 695 700
Asn Ser Ser Phe Ser Arg Ile Glu Lys
705 710
<210> 313
<211> 2147
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(2124)
<223> FRXA02547
<400> 313
gct gcg cgg ctg acc gtg gat gag tat ccg gcg gcg agg gaa gcg ctt 48
Ala Ala Arg Leu Thr Val Asp Glu Tyr Pro Ala Ala Arg Glu Ala Leu
1 5 10 15
gaa tct gca ggt cag agg aat gta gag gac cga acc cgt gcg gtt gat 96
Glu Ser Ala Gly Gln Arg Asn Val Glu Asp Arg Thr Arg Ala Val Asp
20 25 30
gag ttc aaa gcg gcg gat caa gag ctg tct tct ttg agt aaa ggc agc 144
Glu Phe Lys Ala Ala Asp Gln Glu Leu Ser Ser Leu Ser Lys Gly Ser
35 40 45
agt aat att gag tac cgt ttg ctg cag gtg cgg gaa aat ttg tgt cag 192
Ser Asn Ile Glu Tyr Arg Leu Leu Gln Val Arg Glu Asn Leu Cys Gln
50 55 60
gat ttg ggc gtg agc ccg cgg gat atg ccc ttt gcc ggt gag ctg att 240
Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe Ala Gly Glu Leu Ile
65 70 75 80
gat ccg aat aat gcg gaa tgg gaa ccc gtt gtg cag cgc att ttg ggt 288
Asp Pro Asn Asn Ala Glu Trp Glu Pro Val Val Gln Arg Ile Leu Gly
85 90 95
ggt ttt gct gcg gaa atg ttg gtt cct cat ggg ttg ttg cca cgg gtt 336
Gly Phe Ala Ala Glu Met Leu Val Pro His Gly Leu Leu Pro Arg Val
100 105 110
cgg gat tgg gta aat gcc aaa cat ttg gca gcg ctg ctg aaa ttc aac 384
Arg Asp Trp Val Asn Ala Lys His Leu Ala Ala Leu Leu Lys Phe Asn
115 120 125
ggc gtg gtg aca acg ggg gag tac aaa acc tcg cgt ttt ccg gcg gat 432
Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser Arg Phe Pro Ala Asp
130 135 140
tcc ctg atc cga aaa gtt gat gtt gtg gag tcg ccg ttt cgc gat tgg 480
Ser Leu Ile Arg Lys Val Asp Val Val Glu Ser Pro Phe Arg Asp Trp
145 150 155 160
gta aat caa gaa tta ggc aag cgt ttt aat att cgg tgc gtg cgc act 528
Val Asn Gln Glu Leu Gly Lys Arg Phe Asn Ile Arg Cys Val Arg Thr
165 170 175
cct gag gaa ttg tcg gcg ctg ggg cca cgc gat cag ggc gtg acc att 576
Pro Glu Glu Leu Ser Ala Leu Gly Pro Arg Asp Gln Gly Val Thr Ile
180 185 190
ttg ggt gtg cga aaa ttt gcg cag cag aca ggc gat ccg acg acg cgt 624
Leu Gly Val Arg Lys Phe Ala Gln Gln Thr Gly Asp Pro Thr Thr Arg
195 200 205
tgg gaa aaa gat gat cgc cga aag ctg ggg gat cgt tcc aca tac cgt 672
Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp Arg Ser Thr Tyr Arg
210 215 220
ttg ggt tcc acc aat gat gcc aag gtg gaa acg ctt cgg gaa acc gtg 720
Leu Gly Ser Thr Asn Asp Ala Lys Val Glu Thr Leu Arg Glu Thr Val
225 230 235 240
aaa gct ggc aaa gca gtt gtg cag gca gct gat aat cgc att gct gca 768
Lys Ala Gly Lys Ala Val Val Gln Ala Ala Asp Asn Arg Ile Ala Ala
245 250 255
aac cgc gct gag ctg cgg gaa ctt gaa cgg cag tat caa gct tcg caa 816
Asn Arg Ala Glu Leu Arg Glu Leu Glu Arg Gln Tyr Gln Ala Ser Gln
260 265 270
gaa att ttg aaa gtg tcg tgg gct cag att gat gtg gaa tca gcc gac 864
Glu Ile Leu Lys Val Ser Trp Ala Gln Ile Asp Val Glu Ser Ala Asp
275 280 285
gcg gcg att gct gag ctg gac cga ttg ctg gaa gag ctg aac aac act 912
Ala Ala Ile Ala Glu Leu Asp Arg Leu Leu Glu Glu Leu Asn Asn Thr
290 295 300
cca gag gcc acc gag ctt tcc gcg cgg cat gag gcg gcg aag cag acg 960
Pro Glu Ala Thr Glu Leu Ser Ala Arg His Glu Ala Ala Lys Gln Thr
305 310 315 320
ctc gcg agg gtt tct gac ttg ctt gtc gca gct cag agt gag gaa acc 1008
Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala Gln Ser Glu Glu Thr
325 330 335
gtg gcg tcg atg aac ctg aaa cgc gcc gaa act gaa ttg aaa cgg ctc 1056
Val Ala Ser Met Asn Leu Lys Arg Ala Glu Thr Glu Leu Lys Arg Leu
340 345 350
gaa agc ctg ccg gtt gcg gag gtt tct gaa gaa atc gcg cgg gaa gtg 1104
Glu Ser Leu Pro Val Ala Glu Val Ser Glu Glu Ile Ala Arg Glu Val
355 360 365
gag aaa cta ttt ctt gcc aac acc cgc cgg gtt cac gcc gcc aac gtg 1152
Glu Lys Leu Phe Leu Ala Asn Thr Arg Arg Val His Ala Ala Asn Val
370 375 380
gat gag cag acc att gcg ctg cgc gag gat ctg gac aaa caa atc gat 1200
Asp Glu Gln Thr Ile Ala Leu Arg Glu Asp Leu Asp Lys Gln Ile Asp
385 390 395 400
gcc aat gag gca gaa ctt cga cgt tgt gaa aac caa att gtt ggc att 1248
Ala Asn Glu Ala Glu Leu Arg Arg Cys Glu Asn Gln Ile Val Gly Ile
405 410 415
ttg cgc agc tat att gaa acg tgg cct gcg aac cgc gct gac tta caa 1296
Leu Arg Ser Tyr Ile Glu Thr Trp Pro Ala Asn Arg Ala Asp Leu Gln
420 425 430
gcc gaa cct gag ttt gtt ggt gag gcc atc aac cgc ctc ggc gag ctt 1344
Ala Glu Pro Glu Phe Val Gly Glu Ala Ile Asn Arg Leu Gly Glu Leu
435 440 445
cgc agc gat cgt ttg gca gaa ttc acg gcc aaa ttc cta ggg ctc atg 1392
Arg Ser Asp Arg Leu Ala Glu Phe Thr Ala Lys Phe Leu Gly Leu Met
450 455 460
aac gag atg tcc acc cga aac ctc ggc caa atc tcg cgg cgt cta cgt 1440
Asn Glu Met Ser Thr Arg Asn Leu Gly Gln Ile Ser Arg Arg Leu Arg
465 470 475 480
gat gcg cgc cgg gaa atc gag gag cgc atc gag ccg atc aac gcc tcc 1488
Asp Ala Arg Arg Glu Ile Glu Glu Arg Ile Glu Pro Ile Asn Ala Ser
485 490 495
ttg gcg cag tcg gaa ttc aac gaa ggt cgc ttc ctg cac atc gac atc 1536
Leu Ala Gln Ser Glu Phe Asn Glu Gly Arg Phe Leu His Ile Asp Ile
500 505 510
cgt gat caa agt ggt ccg att gtg agg gaa ttc cag cag aaa ctt gat 1584
Arg Asp Gln Ser Gly Pro Ile Val Arg Glu Phe Gln Gln Lys Leu Asp
515 520 525
gcc gct acc agc ggt gac ctg gga acc agt acc gag aaa caa gcc ttc 1632
Ala Ala Thr Ser Gly Asp Leu Gly Thr Ser Thr Glu Lys Gln Ala Phe
530 535 540
gcc cgt tat gcg ctg atc gct gaa atc att tcc aaa ctc gcc tcc cac 1680
Ala Arg Tyr Ala Leu Ile Ala Glu Ile Ile Ser Lys Leu Ala Ser His
545 550 555 560
gac tcc gcc gac gcc cgc tgg cgc aac acc gtt cta gac acc cgc cgc 1728
Asp Ser Ala Asp Ala Arg Trp Arg Asn Thr Val Leu Asp Thr Arg Arg
565 570 575
cac gtt cgc ttc atc ggc ctc gag cgc gat tcc gac ggc gca acc gtc 1776
His Val Arg Phe Ile Gly Leu Glu Arg Asp Ser Asp Gly Ala Thr Val
580 585 590
aac acc tac gtc gac tcc gca tca ctt tca ggc gga caa gcc cag aag 1824
Asn Thr Tyr Val Asp Ser Ala Ser Leu Ser Gly Gly Gln Ala Gln Lys
595 600 605
ctg gtg ttt ttc tgc ctc gcc gct gcc ttg cgc tac cag cta gcc gaa 1872
Leu Val Phe Phe Cys Leu Ala Ala Ala Leu Arg Tyr Gln Leu Ala Glu
610 615 620
ccc ggc gcc cat tat ccc acc tac gcc acc gtc att ctg gac gaa gcc 1920
Pro Gly Ala His Tyr Pro Thr Tyr Ala Thr Val Ile Leu Asp Glu Ala
625 630 635 640
ttc gac cgc gcc gac ccc gcc ttc acc cgc caa acc atg aac gtc ttc 1968
Phe Asp Arg Ala Asp Pro Ala Phe Thr Arg Gln Thr Met Asn Val Phe
645 650 655
cac agc ttc ggc ttc cac atg gtg ctc gcg acc ccg ctg aaa ctt atc 2016
His Ser Phe Gly Phe His Met Val Leu Ala Thr Pro Leu Lys Leu Ile
660 665 670
caa acc ctc ggc gat tat gtc ggc tcc acc atc gtg gtc agc tac acc 2064
Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr Ile Val Val Ser Tyr Thr
675 680 685
gaa aaa cca aac gcc cag ggc gca att cag ggc aat tcc agt ttc tct 2112
Glu Lys Pro Asn Ala Gln Gly Ala Ile Gln Gly Asn Ser Ser Phe Ser
690 695 700
agg atc gag aaa taacatgcca ttgtttatcg acg 2147
Arg Ile Glu Lys
705
<210> 314
<211> 708
<212> PRT
<213> Corynebacterium glutamicum
<400> 314
Ala Ala Arg Leu Thr Val Asp Glu Tyr Pro Ala Ala Arg Glu Ala Leu
1 5 10 15
Glu Ser Ala Gly Gln Arg Asn Val Glu Asp Arg Thr Arg Ala Val Asp
20 25 30
Glu Phe Lys Ala Ala Asp Gln Glu Leu Ser Ser Leu Ser Lys Gly Ser
35 40 45
Ser Asn Ile Glu Tyr Arg Leu Leu Gln Val Arg Glu Asn Leu Cys Gln
50 55 60
Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe Ala Gly Glu Leu Ile
65 70 75 80
Asp Pro Asn Asn Ala Glu Trp Glu Pro Val Val Gln Arg Ile Leu Gly
85 90 95
Gly Phe Ala Ala Glu Met Leu Val Pro His Gly Leu Leu Pro Arg Val
100 105 110
Arg Asp Trp Val Asn Ala Lys His Leu Ala Ala Leu Leu Lys Phe Asn
115 120 125
Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser Arg Phe Pro Ala Asp
130 135 140
Ser Leu Ile Arg Lys Val Asp Val Val Glu Ser Pro Phe Arg Asp Trp
145 150 155 160
Val Asn Gln Glu Leu Gly Lys Arg Phe Asn Ile Arg Cys Val Arg Thr
165 170 175
Pro Glu Glu Leu Ser Ala Leu Gly Pro Arg Asp Gln Gly Val Thr Ile
180 185 190
Leu Gly Val Arg Lys Phe Ala Gln Gln Thr Gly Asp Pro Thr Thr Arg
195 200 205
Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp Arg Ser Thr Tyr Arg
210 215 220
Leu Gly Ser Thr Asn Asp Ala Lys Val Glu Thr Leu Arg Glu Thr Val
225 230 235 240
Lys Ala Gly Lys Ala Val Val Gln Ala Ala Asp Asn Arg Ile Ala Ala
245 250 255
Asn Arg Ala Glu Leu Arg Glu Leu Glu Arg Gln Tyr Gln Ala Ser Gln
260 265 270
Glu Ile Leu Lys Val Ser Trp Ala Gln Ile Asp Val Glu Ser Ala Asp
275 280 285
Ala Ala Ile Ala Glu Leu Asp Arg Leu Leu Glu Glu Leu Asn Asn Thr
290 295 300
Pro Glu Ala Thr Glu Leu Ser Ala Arg His Glu Ala Ala Lys Gln Thr
305 310 315 320
Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala Gln Ser Glu Glu Thr
325 330 335
Val Ala Ser Met Asn Leu Lys Arg Ala Glu Thr Glu Leu Lys Arg Leu
340 345 350
Glu Ser Leu Pro Val Ala Glu Val Ser Glu Glu Ile Ala Arg Glu Val
355 360 365
Glu Lys Leu Phe Leu Ala Asn Thr Arg Arg Val His Ala Ala Asn Val
370 375 380
Asp Glu Gln Thr Ile Ala Leu Arg Glu Asp Leu Asp Lys Gln Ile Asp
385 390 395 400
Ala Asn Glu Ala Glu Leu Arg Arg Cys Glu Asn Gln Ile Val Gly Ile
405 410 415
Leu Arg Ser Tyr Ile Glu Thr Trp Pro Ala Asn Arg Ala Asp Leu Gln
420 425 430
Ala Glu Pro Glu Phe Val Gly Glu Ala Ile Asn Arg Leu Gly Glu Leu
435 440 445
Arg Ser Asp Arg Leu Ala Glu Phe Thr Ala Lys Phe Leu Gly Leu Met
450 455 460
Asn Glu Met Ser Thr Arg Asn Leu Gly Gln Ile Ser Arg Arg Leu Arg
465 470 475 480
Asp Ala Arg Arg Glu Ile Glu Glu Arg Ile Glu Pro Ile Asn Ala Ser
485 490 495
Leu Ala Gln Ser Glu Phe Asn Glu Gly Arg Phe Leu His Ile Asp Ile
500 505 510
Arg Asp Gln Ser Gly Pro Ile Val Arg Glu Phe Gln Gln Lys Leu Asp
515 520 525
Ala Ala Thr Ser Gly Asp Leu Gly Thr Ser Thr Glu Lys Gln Ala Phe
530 535 540
Ala Arg Tyr Ala Leu Ile Ala Glu Ile Ile Ser Lys Leu Ala Ser His
545 550 555 560
Asp Ser Ala Asp Ala Arg Trp Arg Asn Thr Val Leu Asp Thr Arg Arg
565 570 575
His Val Arg Phe Ile Gly Leu Glu Arg Asp Ser Asp Gly Ala Thr Val
580 585 590
Asn Thr Tyr Val Asp Ser Ala Ser Leu Ser Gly Gly Gln Ala Gln Lys
595 600 605
Leu Val Phe Phe Cys Leu Ala Ala Ala Leu Arg Tyr Gln Leu Ala Glu
610 615 620
Pro Gly Ala His Tyr Pro Thr Tyr Ala Thr Val Ile Leu Asp Glu Ala
625 630 635 640
Phe Asp Arg Ala Asp Pro Ala Phe Thr Arg Gln Thr Met Asn Val Phe
645 650 655
His Ser Phe Gly Phe His Met Val Leu Ala Thr Pro Leu Lys Leu Ile
660 665 670
Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr Ile Val Val Ser Tyr Thr
675 680 685
Glu Lys Pro Asn Ala Gln Gly Ala Ile Gln Gly Asn Ser Ser Phe Ser
690 695 700
Arg Ile Glu Lys
705
<210> 315
<211> 1152
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1129)
<223> RXN02571
<400> 315
tggacaggcc ggggccgcgt acggtgttgg ttgaggtggt ggaggggcgc gtcgaaaagc 60
attgtcgctg gttgttgccg cttttggcag tcgggatggc gtg gtg gct cta act 115
Val Val Ala Leu Thr
1 5
caa atc gtc gga ccg tcc ggc tcc ggg ctc acg cgg gaa ttg gaa aaa 163
Gln Ile Val Gly Pro Ser Gly Ser Gly Leu Thr Arg Glu Leu Glu Lys
10 15 20
cgc tac cgg gaa acg ccc gga gcg gtg atg ctg acc gcc gac ccg cgc 211
Arg Tyr Arg Glu Thr Pro Gly Ala Val Met Leu Thr Ala Asp Pro Arg
25 30 35
gcg cat atc acc tac ctg cgc gcg aca gtc gcc gag gag ctg gcc ttt 259
Ala His Ile Thr Tyr Leu Arg Ala Thr Val Ala Glu Glu Leu Ala Phe
40 45 50
ggg ctg gaa caa cgc ggc atc gta ccc gcg cag atg tgg gag cgc gtc 307
Gly Leu Glu Gln Arg Gly Ile Val Pro Ala Gln Met Trp Glu Arg Val
55 60 65
cga aac atc ggg ctc ggc ctc gag aat ctg cta gac cgc gca ccc gcg 355
Arg Asn Ile Gly Leu Gly Leu Glu Asn Leu Leu Asp Arg Ala Pro Ala
70 75 80 85
caa ctt tcc ggc ggg caa aca cgg cgg ctg gcg atc ggc acc gtc gcc 403
Gln Leu Ser Gly Gly Gln Thr Arg Arg Leu Ala Ile Gly Thr Val Ala
90 95 100
atc tta gag gcg cca acg atg ctt ctc gac gac ccc ctc tcc ggt ctt 451
Ile Leu Glu Ala Pro Thr Met Leu Leu Asp Asp Pro Leu Ser Gly Leu
105 110 115
gat acc tcc tcg cga gcc caa ctc atc aca atg ttg gaa tca tat gag 499
Asp Thr Ser Ser Arg Ala Gln Leu Ile Thr Met Leu Glu Ser Tyr Glu
120 125 130
ggc gat gtc atc gtc gct gcg cac aag cgg tgg ctc gac gcg ccg act 547
Gly Asp Val Ile Val Ala Ala His Lys Arg Trp Leu Asp Ala Pro Thr
135 140 145
gtg tac tta ggg gat ttg gag gag ctg tcc ctg cct gcg cgg gtg gaa 595
Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu Pro Ala Arg Val Glu
150 155 160 165
ttt tcc ggt cca tcg cga acg ttt tca gcg att aca gga acc cgc gga 643
Phe Ser Gly Pro Ser Arg Thr Phe Ser Ala Ile Thr Gly Thr Arg Gly
170 175 180
caa caa cgc cga cgc tgg tgg caa ttc aac gaa tcc caa cca cag ttt 691
Gln Gln Arg Arg Arg Trp Trp Gln Phe Asn Glu Ser Gln Pro Gln Phe
185 190 195
cag atc ggc ccc ctg gat att act gtt tct gca ggt caa gtg ctg tgg 739
Gln Ile Gly Pro Leu Asp Ile Thr Val Ser Ala Gly Gln Val Leu Trp
200 205 210
ttg cag ggt ccc aat ggt tca ggg aag tcc aca ctc ctg cgt ggt ctt 787
Leu Gln Gly Pro Asn Gly Ser Gly Lys Ser Thr Leu Leu Arg Gly Leu
215 220 225
gcc aat gaa ccc ggc act gaa ttg atg ctg caa aac cct agc gat caa 835
Ala Asn Glu Pro Gly Thr Glu Leu Met Leu Gln Asn Pro Ser Asp Gln
230 235 240 245
gtc att gac tcc act gtt gct aat tgg gtg cca ggc agt aac agt gaa 883
Val Ile Asp Ser Thr Val Ala Asn Trp Val Pro Gly Ser Asn Ser Glu
250 255 260
gaa cat ccg ctg gat tta tcg caa cgc gaa ctc cgc ctt gcc caa tgc 931
Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu Arg Leu Ala Gln Cys
265 270 275
gac gca gcc ctg ggt aat aac ccg gaa gtt ttg ctt gct gat gaa ccc 979
Asp Ala Ala Leu Gly Asn Asn Pro Glu Val Leu Leu Ala Asp Glu Pro
280 285 290
gac gtc ggc ctt gat gtc ggc ggt cga aac gcc atc cac cag cgc ttt 1027
Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala Ile His Gln Arg Phe
295 300 305
gcg gat ttc tta ggg aat ggg gga gcg ctg atc ctg acc tgc cat gat 1075
Ala Asp Phe Leu Gly Asn Gly Gly Ala Leu Ile Leu Thr Cys His Asp
310 315 320 325
gaa acc ttc gtg gca gag gta gct gaa tac gcg ata gtg aag gaa atg 1123
Glu Thr Phe Val Ala Glu Val Ala Glu Tyr Ala Ile Val Lys Glu Met
330 335 340
ggg ctc taggtttctt tggaccaaac cac 1152
Gly Leu
<210> 316
<211> 343
<212> PRT
<213> Corynebacterium glutamicum
<400> 316
Val Val Ala Leu Thr Gln Ile Val Gly Pro Ser Gly Ser Gly Leu Thr
1 5 10 15
Arg Glu Leu Glu Lys Arg Tyr Arg Glu Thr Pro Gly Ala Val Met Leu
20 25 30
Thr Ala Asp Pro Arg Ala His Ile Thr Tyr Leu Arg Ala Thr Val Ala
35 40 45
Glu Glu Leu Ala Phe Gly Leu Glu Gln Arg Gly Ile Val Pro Ala Gln
50 55 60
Met Trp Glu Arg Val Arg Asn Ile Gly Leu Gly Leu Glu Asn Leu Leu
65 70 75 80
Asp Arg Ala Pro Ala Gln Leu Ser Gly Gly Gln Thr Arg Arg Leu Ala
85 90 95
Ile Gly Thr Val Ala Ile Leu Glu Ala Pro Thr Met Leu Leu Asp Asp
100 105 110
Pro Leu Ser Gly Leu Asp Thr Ser Ser Arg Ala Gln Leu Ile Thr Met
115 120 125
Leu Glu Ser Tyr Glu Gly Asp Val Ile Val Ala Ala His Lys Arg Trp
130 135 140
Leu Asp Ala Pro Thr Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu
145 150 155 160
Pro Ala Arg Val Glu Phe Ser Gly Pro Ser Arg Thr Phe Ser Ala Ile
165 170 175
Thr Gly Thr Arg Gly Gln Gln Arg Arg Arg Trp Trp Gln Phe Asn Glu
180 185 190
Ser Gln Pro Gln Phe Gln Ile Gly Pro Leu Asp Ile Thr Val Ser Ala
195 200 205
Gly Gln Val Leu Trp Leu Gln Gly Pro Asn Gly Ser Gly Lys Ser Thr
210 215 220
Leu Leu Arg Gly Leu Ala Asn Glu Pro Gly Thr Glu Leu Met Leu Gln
225 230 235 240
Asn Pro Ser Asp Gln Val Ile Asp Ser Thr Val Ala Asn Trp Val Pro
245 250 255
Gly Ser Asn Ser Glu Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu
260 265 270
Arg Leu Ala Gln Cys Asp Ala Ala Leu Gly Asn Asn Pro Glu Val Leu
275 280 285
Leu Ala Asp Glu Pro Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala
290 295 300
Ile His Gln Arg Phe Ala Asp Phe Leu Gly Asn Gly Gly Ala Leu Ile
305 310 315 320
Leu Thr Cys His Asp Glu Thr Phe Val Ala Glu Val Ala Glu Tyr Ala
325 330 335
Ile Val Lys Glu Met Gly Leu
340
<210> 317
<211> 1152
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1129)
<223> FRXA02571
<400> 317
tggacaggcc ggggccgcgt acggtgttgg ttgaggtggt ggaggggcgc gtcgaaaagc 60
attgtcgctg gttgttgccg cttttggcag tcgggatggc gtg gtg gct cta act 115
Val Val Ala Leu Thr
1 5
caa atc gtc gga ccg tcc ggc tcc ggg ctc acg cgg gaa ttg gaa aaa 163
Gln Ile Val Gly Pro Ser Gly Ser Gly Leu Thr Arg Glu Leu Glu Lys
10 15 20
cgc tac cgg gaa acg ccc gga gcg gtg atg ctg acc gcc gac ccg cgc 211
Arg Tyr Arg Glu Thr Pro Gly Ala Val Met Leu Thr Ala Asp Pro Arg
25 30 35
gcg cat atc acc tac ctg cgc gcg aca gtc gcc gag gag ctg gcc ttt 259
Ala His Ile Thr Tyr Leu Arg Ala Thr Val Ala Glu Glu Leu Ala Phe
40 45 50
ggg ctg gaa caa cgc ggc atc gta ccc gcg cag atg tgg gag cgc gtc 307
Gly Leu Glu Gln Arg Gly Ile Val Pro Ala Gln Met Trp Glu Arg Val
55 60 65
cga aac atc ggg ctc ggc ctc gag aat ctg cta gac cgc gca ccc gcg 355
Arg Asn Ile Gly Leu Gly Leu Glu Asn Leu Leu Asp Arg Ala Pro Ala
70 75 80 85
caa ctt tcc ggc ggg caa aca cgg cgg ctg gcg atc ggc acc gtc gcc 403
Gln Leu Ser Gly Gly Gln Thr Arg Arg Leu Ala Ile Gly Thr Val Ala
90 95 100
atc tta gag gcg cca acg atg ctt ctc gac gac ccc ctc tcc ggt ctt 451
Ile Leu Glu Ala Pro Thr Met Leu Leu Asp Asp Pro Leu Ser Gly Leu
105 110 115
gat acc tcc tcg cga gcc caa ctc atc aca atg ttg gaa tca tat gag 499
Asp Thr Ser Ser Arg Ala Gln Leu Ile Thr Met Leu Glu Ser Tyr Glu
120 125 130
ggc gat gtc atc gtc gct gcg cac aag cgg tgg ctc gac gcg ccg act 547
Gly Asp Val Ile Val Ala Ala His Lys Arg Trp Leu Asp Ala Pro Thr
135 140 145
gtg tac tta ggg gat ttg gag gag ctg tcc ctg cct gcg cgg gtg gaa 595
Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu Pro Ala Arg Val Glu
150 155 160 165
ttt tcc ggt cca tcg cga acg ttt tca gcg att aca gga acc cgc gga 643
Phe Ser Gly Pro Ser Arg Thr Phe Ser Ala Ile Thr Gly Thr Arg Gly
170 175 180
caa caa cgc cga cgc tgg tgg caa ttc aac gaa tcc caa cca cag ttt 691
Gln Gln Arg Arg Arg Trp Trp Gln Phe Asn Glu Ser Gln Pro Gln Phe
185 190 195
cag atc ggc ccc ctg gat att act gtt tct gca ggt caa gtg ctg tgg 739
Gln Ile Gly Pro Leu Asp Ile Thr Val Ser Ala Gly Gln Val Leu Trp
200 205 210
ttg cag ggt ccc aat ggt tca ggg aag tcc aca ctc ctg cgt ggt ctt 787
Leu Gln Gly Pro Asn Gly Ser Gly Lys Ser Thr Leu Leu Arg Gly Leu
215 220 225
gcc aat gaa ccc ggc act gaa ttg atg ctg caa aac cct agc gat caa 835
Ala Asn Glu Pro Gly Thr Glu Leu Met Leu Gln Asn Pro Ser Asp Gln
230 235 240 245
gtc att gac tcc act gtt gct aat tgg gtg cca ggc agt aac agt gaa 883
Val Ile Asp Ser Thr Val Ala Asn Trp Val Pro Gly Ser Asn Ser Glu
250 255 260
gaa cat ccg ctg gat tta tcg caa cgc gaa ctc cgc ctt gcc caa tgc 931
Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu Arg Leu Ala Gln Cys
265 270 275
gac gca gcc ctg ggt aat aac ccg gaa gtt ttg ctt gct gat gaa ccc 979
Asp Ala Ala Leu Gly Asn Asn Pro Glu Val Leu Leu Ala Asp Glu Pro
280 285 290
gac gtc ggc ctt gat gtc ggc ggt cga aac gcc atc cac cag cgc ttt 1027
Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala Ile His Gln Arg Phe
295 300 305
gcg gat ttc tta ggg aat ggg gga gcg ctg atc ctg acc tgc cat gat 1075
Ala Asp Phe Leu Gly Asn Gly Gly Ala Leu Ile Leu Thr Cys His Asp
310 315 320 325
gaa acc ttc gtg gca gag gta gct gaa tac gcg ata gtg aag gaa atg 1123
Glu Thr Phe Val Ala Glu Val Ala Glu Tyr Ala Ile Val Lys Glu Met
330 335 340
ggg ctc taggtttctt tggaccaaac cac 1152
Gly Leu
<210> 318
<211> 343
<212> PRT
<213> Corynebacterium glutamicum
<400> 318
Val Val Ala Leu Thr Gln Ile Val Gly Pro Ser Gly Ser Gly Leu Thr
1 5 10 15
Arg Glu Leu Glu Lys Arg Tyr Arg Glu Thr Pro Gly Ala Val Met Leu
20 25 30
Thr Ala Asp Pro Arg Ala His Ile Thr Tyr Leu Arg Ala Thr Val Ala
35 40 45
Glu Glu Leu Ala Phe Gly Leu Glu Gln Arg Gly Ile Val Pro Ala Gln
50 55 60
Met Trp Glu Arg Val Arg Asn Ile Gly Leu Gly Leu Glu Asn Leu Leu
65 70 75 80
Asp Arg Ala Pro Ala Gln Leu Ser Gly Gly Gln Thr Arg Arg Leu Ala
85 90 95
Ile Gly Thr Val Ala Ile Leu Glu Ala Pro Thr Met Leu Leu Asp Asp
100 105 110
Pro Leu Ser Gly Leu Asp Thr Ser Ser Arg Ala Gln Leu Ile Thr Met
115 120 125
Leu Glu Ser Tyr Glu Gly Asp Val Ile Val Ala Ala His Lys Arg Trp
130 135 140
Leu Asp Ala Pro Thr Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu
145 150 155 160
Pro Ala Arg Val Glu Phe Ser Gly Pro Ser Arg Thr Phe Ser Ala Ile
165 170 175
Thr Gly Thr Arg Gly Gln Gln Arg Arg Arg Trp Trp Gln Phe Asn Glu
180 185 190
Ser Gln Pro Gln Phe Gln Ile Gly Pro Leu Asp Ile Thr Val Ser Ala
195 200 205
Gly Gln Val Leu Trp Leu Gln Gly Pro Asn Gly Ser Gly Lys Ser Thr
210 215 220
Leu Leu Arg Gly Leu Ala Asn Glu Pro Gly Thr Glu Leu Met Leu Gln
225 230 235 240
Asn Pro Ser Asp Gln Val Ile Asp Ser Thr Val Ala Asn Trp Val Pro
245 250 255
Gly Ser Asn Ser Glu Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu
260 265 270
Arg Leu Ala Gln Cys Asp Ala Ala Leu Gly Asn Asn Pro Glu Val Leu
275 280 285
Leu Ala Asp Glu Pro Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala
290 295 300
Ile His Gln Arg Phe Ala Asp Phe Leu Gly Asn Gly Gly Ala Leu Ile
305 310 315 320
Leu Thr Cys His Asp Glu Thr Phe Val Ala Glu Val Ala Glu Tyr Ala
325 330 335
Ile Val Lys Glu Met Gly Leu
340
<210> 319
<211> 1746
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1723)
<223> RXN02074
<400> 319
cgggggaagg ccgtgtcgca tgctcgggct agccttggat ctcaagaaga attcgactgg 60
tttaaagtct gggctttaag tgcagaaagg ttgtggattg atg cgc tcc ctg ctt 115
Met Arg Ser Leu Leu
1 5
cgt gat atc cct gcg gtg ggt tgg cta atc acc gcg acg att gtt gtg 163
Arg Asp Ile Pro Ala Val Gly Trp Leu Ile Thr Ala Thr Ile Val Val
10 15 20
cgc acg ctc gtt gtt gcg ctg gtc atc gtt ggg atc ggc ttg ctt atc 211
Arg Thr Leu Val Val Ala Leu Val Ile Val Gly Ile Gly Leu Leu Ile
25 30 35
gac gtc ccc tcg ccc gct cat tca gcc atg ttg tgg tgg gtt ctg gca 259
Asp Val Pro Ser Pro Ala His Ser Ala Met Leu Trp Trp Val Leu Ala
40 45 50
ggt gcc acg gca gca gct gcg ctg ctg tgc gcg gaa gcg gtg ctc ccc 307
Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala Glu Ala Val Leu Pro
55 60 65
caa cgt att cgt gca cga gtt gaa cga tcc tgg cgg cgg cag ttg gct 355
Gln Arg Ile Arg Ala Arg Val Glu Arg Ser Trp Arg Arg Gln Leu Ala
70 75 80 85
gct aaa aat ctg gag ctg aat tcc agt tcg tca gat gat gcc cag ttg 403
Ala Lys Asn Leu Glu Leu Asn Ser Ser Ser Ser Asp Asp Ala Gln Leu
90 95 100
atc aca ctg gca act gaa gcc acc tca aaa gca tcc act tac aca gtg 451
Ile Thr Leu Ala Thr Glu Ala Thr Ser Lys Ala Ser Thr Tyr Thr Val
105 110 115
atg ttt ctg ggg cct tac ttt gca gta ttt ttg gcc cca ctg aca gtt 499
Met Phe Leu Gly Pro Tyr Phe Ala Val Phe Leu Ala Pro Leu Thr Val
120 125 130
att gcc gtt gtc ggc gcg gct att tcc tgg ccg att gcg ggg ata ctg 547
Ile Ala Val Val Gly Ala Ala Ile Ser Trp Pro Ile Ala Gly Ile Leu
135 140 145
tgc ctc ggg ttg tgc gtg ata cct ttc gtt att tct tgg gca cag cgc 595
Cys Leu Gly Leu Cys Val Ile Pro Phe Val Ile Ser Trp Ala Gln Arg
150 155 160 165
atg ttg aaa ggc gct ggc gcg gga tac ggg cga gca tct ggg cag ttg 643
Met Leu Lys Gly Ala Gly Ala Gly Tyr Gly Arg Ala Ser Gly Gln Leu
170 175 180
gca ggc gtg ttt ttg gaa tcg gtg cgc aca cta ggc acc acg atg atg 691
Ala Gly Val Phe Leu Glu Ser Val Arg Thr Leu Gly Thr Thr Met Met
185 190 195
ctg aat gcc gct ggg cag cgc agg cag atc atc aca cag cgc gca gag 739
Leu Asn Ala Ala Gly Gln Arg Arg Gln Ile Ile Thr Gln Arg Ala Glu
200 205 210
aat atg cgc tcc caa gtg atg tca ttg ctg tac cga aat cag ttg atg 787
Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr Arg Asn Gln Leu Met
215 220 225
att ctg gtg acc gac ggc gtg ttt gga gtt gcc acc aca atg gtt gct 835
Ile Leu Val Thr Asp Gly Val Phe Gly Val Ala Thr Thr Met Val Ala
230 235 240 245
gcg gtg ttt gcc att gga gga ttc ttt tca ggc tct ctt act ctc ggc 883
Ala Val Phe Ala Ile Gly Gly Phe Phe Ser Gly Ser Leu Thr Leu Gly
250 255 260
caa gct gta gca ctc gta ttg ctg gcc agg ctg ctt att gat ccc atc 931
Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu Leu Ile Asp Pro Ile
265 270 275
aac cgc atg ggt cgc acg ttt tac acc ggc atg gca ggc aaa ccc tcg 979
Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met Ala Gly Lys Pro Ser
280 285 290
ctg atc gcc att gaa aaa gcc ctc gcg aca acc ttt act gat cag cca 1027
Leu Ile Ala Ile Glu Lys Ala Leu Ala Thr Thr Phe Thr Asp Gln Pro
295 300 305
act caa cag gga cag cgc cac gat ggg gat ctg gtg gtc aac aac ttg 1075
Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu Val Val Asn Asn Leu
310 315 320 325
aag atc gcc cgc gat cac agg gac att gtg cac ggt atc tct ttc agc 1123
Lys Ile Ala Arg Asp His Arg Asp Ile Val His Gly Ile Ser Phe Ser
330 335 340
att ccc cgc ggt tcc cac atc gcg gtg gta ggt ccc agt ggc gct ggt 1171
Ile Pro Arg Gly Ser His Ile Ala Val Val Gly Pro Ser Gly Ala Gly
345 350 355
aaa tcc tct gtg gct cta gcg ttg tcc gga ctt tta gag ttt gat ggt 1219
Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu Leu Glu Phe Asp Gly
360 365 370
gcg att tcc ctc ggc ggc cac aac tgt gag atg tta gat ctt cgc gcc 1267
Ala Ile Ser Leu Gly Gly His Asn Cys Glu Met Leu Asp Leu Arg Ala
375 380 385
tca gtc agt ttc gtg ccc caa tcc ccc acg ctg ttt agc gga agc atc 1315
Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu Phe Ser Gly Ser Ile
390 395 400 405
aaa agc aat atc gat ctg gcg cgc acg ggt gtt gat tct gat cac atc 1363
Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val Asp Ser Asp His Ile
410 415 420
cac gca gca ctt tta ggc gaa gaa ctc ccc gcg gac ctc aaa gtc ggt 1411
His Ala Ala Leu Leu Gly Glu Glu Leu Pro Ala Asp Leu Lys Val Gly
425 430 435
gaa acc ggc aaa ggt gtc tcc ggc ggc caa gca gca cgc att tcc att 1459
Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Ala Ala Arg Ile Ser Ile
440 445 450
gcc cga ggt tta gta aag aat gct gcc gtg att gtt ctc gac gag gcg 1507
Ala Arg Gly Leu Val Lys Asn Ala Ala Val Ile Val Leu Asp Glu Ala
455 460 465
acc gca caa ctc gac tac acc aac gcc cgc cag gtt cga cat ctt gcc 1555
Thr Ala Gln Leu Asp Tyr Thr Asn Ala Arg Gln Val Arg His Leu Ala
470 475 480 485
aaa tcc ctt gag tgc acg ttg gtt gag atc acc cac cgc cca tca gaa 1603
Lys Ser Leu Glu Cys Thr Leu Val Glu Ile Thr His Arg Pro Ser Glu
490 495 500
gcc ctc gat gca gac ttc atc att gtt tta gag gat ggc caa ttg acc 1651
Ala Leu Asp Ala Asp Phe Ile Ile Val Leu Glu Asp Gly Gln Leu Thr
505 510 515
atg atg gat aca ccc agc aac gtt tcc cag cac aat gcg ttt ttc cgc 1699
Met Met Asp Thr Pro Ser Asn Val Ser Gln His Asn Ala Phe Phe Arg
520 525 530
acc gct gtg atg gag gaa gaa caa tgatttcccg acttctccaa ttg 1746
Thr Ala Val Met Glu Glu Glu Gln
535 540
<210> 320
<211> 541
<212> PRT
<213> Corynebacterium glutamicum
<400> 320
Met Arg Ser Leu Leu Arg Asp Ile Pro Ala Val Gly Trp Leu Ile Thr
1 5 10 15
Ala Thr Ile Val Val Arg Thr Leu Val Val Ala Leu Val Ile Val Gly
20 25 30
Ile Gly Leu Leu Ile Asp Val Pro Ser Pro Ala His Ser Ala Met Leu
35 40 45
Trp Trp Val Leu Ala Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala
50 55 60
Glu Ala Val Leu Pro Gln Arg Ile Arg Ala Arg Val Glu Arg Ser Trp
65 70 75 80
Arg Arg Gln Leu Ala Ala Lys Asn Leu Glu Leu Asn Ser Ser Ser Ser
85 90 95
Asp Asp Ala Gln Leu Ile Thr Leu Ala Thr Glu Ala Thr Ser Lys Ala
100 105 110
Ser Thr Tyr Thr Val Met Phe Leu Gly Pro Tyr Phe Ala Val Phe Leu
115 120 125
Ala Pro Leu Thr Val Ile Ala Val Val Gly Ala Ala Ile Ser Trp Pro
130 135 140
Ile Ala Gly Ile Leu Cys Leu Gly Leu Cys Val Ile Pro Phe Val Ile
145 150 155 160
Ser Trp Ala Gln Arg Met Leu Lys Gly Ala Gly Ala Gly Tyr Gly Arg
165 170 175
Ala Ser Gly Gln Leu Ala Gly Val Phe Leu Glu Ser Val Arg Thr Leu
180 185 190
Gly Thr Thr Met Met Leu Asn Ala Ala Gly Gln Arg Arg Gln Ile Ile
195 200 205
Thr Gln Arg Ala Glu Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr
210 215 220
Arg Asn Gln Leu Met Ile Leu Val Thr Asp Gly Val Phe Gly Val Ala
225 230 235 240
Thr Thr Met Val Ala Ala Val Phe Ala Ile Gly Gly Phe Phe Ser Gly
245 250 255
Ser Leu Thr Leu Gly Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu
260 265 270
Leu Ile Asp Pro Ile Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met
275 280 285
Ala Gly Lys Pro Ser Leu Ile Ala Ile Glu Lys Ala Leu Ala Thr Thr
290 295 300
Phe Thr Asp Gln Pro Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu
305 310 315 320
Val Val Asn Asn Leu Lys Ile Ala Arg Asp His Arg Asp Ile Val His
325 330 335
Gly Ile Ser Phe Ser Ile Pro Arg Gly Ser His Ile Ala Val Val Gly
340 345 350
Pro Ser Gly Ala Gly Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu
355 360 365
Leu Glu Phe Asp Gly Ala Ile Ser Leu Gly Gly His Asn Cys Glu Met
370 375 380
Leu Asp Leu Arg Ala Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu
385 390 395 400
Phe Ser Gly Ser Ile Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val
405 410 415
Asp Ser Asp His Ile His Ala Ala Leu Leu Gly Glu Glu Leu Pro Ala
420 425 430
Asp Leu Lys Val Gly Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Ala
435 440 445
Ala Arg Ile Ser Ile Ala Arg Gly Leu Val Lys Asn Ala Ala Val Ile
450 455 460
Val Leu Asp Glu Ala Thr Ala Gln Leu Asp Tyr Thr Asn Ala Arg Gln
465 470 475 480
Val Arg His Leu Ala Lys Ser Leu Glu Cys Thr Leu Val Glu Ile Thr
485 490 495
His Arg Pro Ser Glu Ala Leu Asp Ala Asp Phe Ile Ile Val Leu Glu
500 505 510
Asp Gly Gln Leu Thr Met Met Asp Thr Pro Ser Asn Val Ser Gln His
515 520 525
Asn Ala Phe Phe Arg Thr Ala Val Met Glu Glu Glu Gln
530 535 540
<210> 321
<211> 1746
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1723)
<223> FRXA02074
<400> 321
cgggggaagg ccgtgtcgca tgctcgggct agccttggat ctcaagaaga attcgactgg 60
tttaaagtct gggctttaag tgcagaaagg ttgtggattg atg cgc tcc ctg ctt 115
Met Arg Ser Leu Leu
1 5
cgt gat atc cct gcg gtg ggt tgg cta atc acc gcg acg att gtt gtg 163
Arg Asp Ile Pro Ala Val Gly Trp Leu Ile Thr Ala Thr Ile Val Val
10 15 20
cgc acg ctc gtt gtt gcg ctg gtc atc gtt ggg atc ggc ttg ctt atc 211
Arg Thr Leu Val Val Ala Leu Val Ile Val Gly Ile Gly Leu Leu Ile
25 30 35
gac gtc ccc tcg ccc gct cat tca gcc atg ttg tgg tgg gtt ctg gca 259
Asp Val Pro Ser Pro Ala His Ser Ala Met Leu Trp Trp Val Leu Ala
40 45 50
ggt gcc acg gca gca gct gcg ctg ctg tgc gcg gaa gcg gtg ctc ccc 307
Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala Glu Ala Val Leu Pro
55 60 65
caa cgt att cgt gca cga gtt gaa cga tcc tgg cgg cgg cag ttg gct 355
Gln Arg Ile Arg Ala Arg Val Glu Arg Ser Trp Arg Arg Gln Leu Ala
70 75 80 85
gct aaa aat ctg gag ctg aat tcc agt tcg tca gat gat gcc cag ttg 403
Ala Lys Asn Leu Glu Leu Asn Ser Ser Ser Ser Asp Asp Ala Gln Leu
90 95 100
atc aca ctg gca act gaa gcc acc tca aaa gca tcc act tac aca gtg 451
Ile Thr Leu Ala Thr Glu Ala Thr Ser Lys Ala Ser Thr Tyr Thr Val
105 110 115
atg ttt ctg ggg cct tac ttt gca gta ttt ttg gcc cca ctg aca gtt 499
Met Phe Leu Gly Pro Tyr Phe Ala Val Phe Leu Ala Pro Leu Thr Val
120 125 130
att gcc gtt gtc ggc gcg gct att tcc tgg ccg att gcg ggg ata ctg 547
Ile Ala Val Val Gly Ala Ala Ile Ser Trp Pro Ile Ala Gly Ile Leu
135 140 145
tgc ctc ggg ttg tgc gtg ata cct ttc gtt att tct tgg gca cag cgc 595
Cys Leu Gly Leu Cys Val Ile Pro Phe Val Ile Ser Trp Ala Gln Arg
150 155 160 165
atg ttg aaa ggc gct ggc gcg gga tac ggg cga gca tct ggg cag ttg 643
Met Leu Lys Gly Ala Gly Ala Gly Tyr Gly Arg Ala Ser Gly Gln Leu
170 175 180
gca ggc gtg ttt ttg gaa tcg gtg cgc aca cta ggc acc acg atg atg 691
Ala Gly Val Phe Leu Glu Ser Val Arg Thr Leu Gly Thr Thr Met Met
185 190 195
ctg aat gcc gct ggg cag cgc agg cag atc atc aca cag cgc gca gag 739
Leu Asn Ala Ala Gly Gln Arg Arg Gln Ile Ile Thr Gln Arg Ala Glu
200 205 210
aat atg cgc tcc caa gtg atg tca ttg ctg tac cga aat cag ttg atg 787
Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr Arg Asn Gln Leu Met
215 220 225
att ctg gtg acc gac ggc gtg ttt gga gtt gcc acc aca atg gtt gct 835
Ile Leu Val Thr Asp Gly Val Phe Gly Val Ala Thr Thr Met Val Ala
230 235 240 245
gcg gtg ttt gcc att gga gga ttc ttt tca ggc tct ctt act ctc ggc 883
Ala Val Phe Ala Ile Gly Gly Phe Phe Ser Gly Ser Leu Thr Leu Gly
250 255 260
caa gct gta gca ctc gta ttg ctg gcc agg ctg ctt att gat ccc atc 931
Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu Leu Ile Asp Pro Ile
265 270 275
aac cgc atg ggt cgc acg ttt tac acc ggc atg gca ggc aaa ccc tcg 979
Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met Ala Gly Lys Pro Ser
280 285 290
ctg atc gcc att gaa aaa gcc ctc gcg aca acc ttt act gat cag cca 1027
Leu Ile Ala Ile Glu Lys Ala Leu Ala Thr Thr Phe Thr Asp Gln Pro
295 300 305
act caa cag gga cag cgc cac gat ggg gat ctg gtg gtc aac aac ttg 1075
Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu Val Val Asn Asn Leu
310 315 320 325
aag atc gcc cgc gat cac agg gac att gtg cac ggt atc tct ttc agc 1123
Lys Ile Ala Arg Asp His Arg Asp Ile Val His Gly Ile Ser Phe Ser
330 335 340
att ccc cgc ggt tcc cac atc gcg gtg gta ggt ccc agt ggc gct ggt 1171
Ile Pro Arg Gly Ser His Ile Ala Val Val Gly Pro Ser Gly Ala Gly
345 350 355
aaa tcc tct gtg gct cta gcg ttg tcc gga ctt tta gag ttt gat ggt 1219
Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu Leu Glu Phe Asp Gly
360 365 370
gcg att tcc ctc ggc ggc cac aac tgt gag atg tta gat ctt cgc gcc 1267
Ala Ile Ser Leu Gly Gly His Asn Cys Glu Met Leu Asp Leu Arg Ala
375 380 385
tca gtc agt ttc gtg ccc caa tcc ccc acg ctg ttt agc gga agc atc 1315
Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu Phe Ser Gly Ser Ile
390 395 400 405
aaa agc aat atc gat ctg gcg cgc acg ggt gtt gat tct gat cac atc 1363
Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val Asp Ser Asp His Ile
410 415 420
cac gca gca ctt tta ggc gaa gaa ctc ccc gcg gac ctc aaa gtc ggt 1411
His Ala Ala Leu Leu Gly Glu Glu Leu Pro Ala Asp Leu Lys Val Gly
425 430 435
gaa acc ggc aaa ggt gtc tcc ggc ggc caa gca gca cgc att tcc att 1459
Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Ala Ala Arg Ile Ser Ile
440 445 450
gcc cga ggt tta gta aag aat gct gcc gtg att gtt ctc gac gag gcg 1507
Ala Arg Gly Leu Val Lys Asn Ala Ala Val Ile Val Leu Asp Glu Ala
455 460 465
acc gca caa ctc gac tac acc aac gcc cgc cag gtt cga cat ctt gcc 1555
Thr Ala Gln Leu Asp Tyr Thr Asn Ala Arg Gln Val Arg His Leu Ala
470 475 480 485
aaa tcc ctt gag tgc acg ttg gtt gag atc acc cac cgc cca tca gaa 1603
Lys Ser Leu Glu Cys Thr Leu Val Glu Ile Thr His Arg Pro Ser Glu
490 495 500
gcc ctc gat gca gac ttc atc att gtt tta gag gat ggc caa ttg acc 1651
Ala Leu Asp Ala Asp Phe Ile Ile Val Leu Glu Asp Gly Gln Leu Thr
505 510 515
atg atg gat aca ccc agc aac gtt tcc cag cac aat gcg ttt ttc cgc 1699
Met Met Asp Thr Pro Ser Asn Val Ser Gln His Asn Ala Phe Phe Arg
520 525 530
acc gct gtg atg gag gaa gaa caa tgatttcccg acttctccaa ttg 1746
Thr Ala Val Met Glu Glu Glu Gln
535 540
<210> 322
<211> 541
<212> PRT
<213> Corynebacterium glutamicum
<400> 322
Met Arg Ser Leu Leu Arg Asp Ile Pro Ala Val Gly Trp Leu Ile Thr
1 5 10 15
Ala Thr Ile Val Val Arg Thr Leu Val Val Ala Leu Val Ile Val Gly
20 25 30
Ile Gly Leu Leu Ile Asp Val Pro Ser Pro Ala His Ser Ala Met Leu
35 40 45
Trp Trp Val Leu Ala Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala
50 55 60
Glu Ala Val Leu Pro Gln Arg Ile Arg Ala Arg Val Glu Arg Ser Trp
65 70 75 80
Arg Arg Gln Leu Ala Ala Lys Asn Leu Glu Leu Asn Ser Ser Ser Ser
85 90 95
Asp Asp Ala Gln Leu Ile Thr Leu Ala Thr Glu Ala Thr Ser Lys Ala
100 105 110
Ser Thr Tyr Thr Val Met Phe Leu Gly Pro Tyr Phe Ala Val Phe Leu
115 120 125
Ala Pro Leu Thr Val Ile Ala Val Val Gly Ala Ala Ile Ser Trp Pro
130 135 140
Ile Ala Gly Ile Leu Cys Leu Gly Leu Cys Val Ile Pro Phe Val Ile
145 150 155 160
Ser Trp Ala Gln Arg Met Leu Lys Gly Ala Gly Ala Gly Tyr Gly Arg
165 170 175
Ala Ser Gly Gln Leu Ala Gly Val Phe Leu Glu Ser Val Arg Thr Leu
180 185 190
Gly Thr Thr Met Met Leu Asn Ala Ala Gly Gln Arg Arg Gln Ile Ile
195 200 205
Thr Gln Arg Ala Glu Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr
210 215 220
Arg Asn Gln Leu Met Ile Leu Val Thr Asp Gly Val Phe Gly Val Ala
225 230 235 240
Thr Thr Met Val Ala Ala Val Phe Ala Ile Gly Gly Phe Phe Ser Gly
245 250 255
Ser Leu Thr Leu Gly Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu
260 265 270
Leu Ile Asp Pro Ile Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met
275 280 285
Ala Gly Lys Pro Ser Leu Ile Ala Ile Glu Lys Ala Leu Ala Thr Thr
290 295 300
Phe Thr Asp Gln Pro Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu
305 310 315 320
Val Val Asn Asn Leu Lys Ile Ala Arg Asp His Arg Asp Ile Val His
325 330 335
Gly Ile Ser Phe Ser Ile Pro Arg Gly Ser His Ile Ala Val Val Gly
340 345 350
Pro Ser Gly Ala Gly Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu
355 360 365
Leu Glu Phe Asp Gly Ala Ile Ser Leu Gly Gly His Asn Cys Glu Met
370 375 380
Leu Asp Leu Arg Ala Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu
385 390 395 400
Phe Ser Gly Ser Ile Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val
405 410 415
Asp Ser Asp His Ile His Ala Ala Leu Leu Gly Glu Glu Leu Pro Ala
420 425 430
Asp Leu Lys Val Gly Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Ala
435 440 445
Ala Arg Ile Ser Ile Ala Arg Gly Leu Val Lys Asn Ala Ala Val Ile
450 455 460
Val Leu Asp Glu Ala Thr Ala Gln Leu Asp Tyr Thr Asn Ala Arg Gln
465 470 475 480
Val Arg His Leu Ala Lys Ser Leu Glu Cys Thr Leu Val Glu Ile Thr
485 490 495
His Arg Pro Ser Glu Ala Leu Asp Ala Asp Phe Ile Ile Val Leu Glu
500 505 510
Asp Gly Gln Leu Thr Met Met Asp Thr Pro Ser Asn Val Ser Gln His
515 520 525
Asn Ala Phe Phe Arg Thr Ala Val Met Glu Glu Glu Gln
530 535 540
<210> 323
<211> 1527
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1504)
<223> RXA02095
<400> 323
ctctcttggt cctctcccca cccattttta agtactcaag acccttccaa cagaaaggat 60
tactccccca acaggctcaa aaatactgaa aggctcacgc atg aaa act gag caa 115
Met Lys Thr Glu Gln
1 5
tcc caa aaa gca caa tta gcc cct aag aaa gca cct gaa aag cca caa 163
Ser Gln Lys Ala Gln Leu Ala Pro Lys Lys Ala Pro Glu Lys Pro Gln
10 15 20
cgc atc cgc caa ctt att tcc gtg gcg tgg cag cga cct tgg ctc acc 211
Arg Ile Arg Gln Leu Ile Ser Val Ala Trp Gln Arg Pro Trp Leu Thr
25 30 35
tca ttc acc gta atc agc gct tta gct gca acg ttg ttt gaa ctt aca 259
Ser Phe Thr Val Ile Ser Ala Leu Ala Ala Thr Leu Phe Glu Leu Thr
40 45 50
ctt cct ctt ttg acc ggt ggc gcc atc gat atc gcg ctc gga aat acc 307
Leu Pro Leu Leu Thr Gly Gly Ala Ile Asp Ile Ala Leu Gly Asn Thr
55 60 65
gga gat act tta acc act gac ctg ctg gac cgg ttc act ccg agt gga 355
Gly Asp Thr Leu Thr Thr Asp Leu Leu Asp Arg Phe Thr Pro Ser Gly
70 75 80 85
tta agc gtg ttg acc agc gtc att gcc ctt atc gtg ctt ctc gcg ttg 403
Leu Ser Val Leu Thr Ser Val Ile Ala Leu Ile Val Leu Leu Ala Leu
90 95 100
ctt cgc tat gcc agt caa ttt gga cgg cga tac acc gca ggc aag ctc 451
Leu Arg Tyr Ala Ser Gln Phe Gly Arg Arg Tyr Thr Ala Gly Lys Leu
105 110 115
agc atg ggg gta cag cat gat gtc cgg ctt aaa acg atg cgc tca ttg 499
Ser Met Gly Val Gln His Asp Val Arg Leu Lys Thr Met Arg Ser Leu
120 125 130
cag aac ctc gat ggg cca ggt cag gac tct att cgc aca ggc caa gta 547
Gln Asn Leu Asp Gly Pro Gly Gln Asp Ser Ile Arg Thr Gly Gln Val
135 140 145
gtc agt cgg tcc att tcg gat atc aac atg gtg caa agc ctt gtg gcg 595
Val Ser Arg Ser Ile Ser Asp Ile Asn Met Val Gln Ser Leu Val Ala
150 155 160 165
atg ttg ccg atg ttg atc gga aat gtg gtc aag ctt gtg ctc act ttg 643
Met Leu Pro Met Leu Ile Gly Asn Val Val Lys Leu Val Leu Thr Leu
170 175 180
gtg atc atg ctg gct att tcc ccg ccg ctg acc atc atc gct gca gtg 691
Val Ile Met Leu Ala Ile Ser Pro Pro Leu Thr Ile Ile Ala Ala Val
185 190 195
ttg gtg cct ttg ctg ttg tgg gcc gtg gcc tat tcg cga aaa gcg ctt 739
Leu Val Pro Leu Leu Leu Trp Ala Val Ala Tyr Ser Arg Lys Ala Leu
200 205 210
ttt gcg tcc acg tgg tcg gcc cag caa aag gct gcg gat ctg acc act 787
Phe Ala Ser Thr Trp Ser Ala Gln Gln Lys Ala Ala Asp Leu Thr Thr
215 220 225
cat gtg gaa gaa act gtc acg ggt atc cgc gtg gtc aag gca ttt gcg 835
His Val Glu Glu Thr Val Thr Gly Ile Arg Val Val Lys Ala Phe Ala
230 235 240 245
cag gaa gac cgc gag acc gac aaa ttg gat ctc acc gca cgt gag tta 883
Gln Glu Asp Arg Glu Thr Asp Lys Leu Asp Leu Thr Ala Arg Glu Leu
250 255 260
ttt gcc cag cgc atg cgc act gca cgt ctg acg gca aag ttc atc ccc 931
Phe Ala Gln Arg Met Arg Thr Ala Arg Leu Thr Ala Lys Phe Ile Pro
265 270 275
atg gtt gag cag ctt ccg cag ctt gct ttg gtg gtc aac att gtt ggc 979
Met Val Glu Gln Leu Pro Gln Leu Ala Leu Val Val Asn Ile Val Gly
280 285 290
ggt ggc tat ttg gcc atg act ggt cac atc acg gtg ggc acg ttt gtg 1027
Gly Gly Tyr Leu Ala Met Thr Gly His Ile Thr Val Gly Thr Phe Val
295 300 305
gcg ttt tct tcc tat ctc act agc ttg tcg gcg gtg gct agg tcc ctg 1075
Ala Phe Ser Ser Tyr Leu Thr Ser Leu Ser Ala Val Ala Arg Ser Leu
310 315 320 325
tcg ggc atg ctc atg cgc gtg cag ttg gcg ctg tct tct gtg gag cgc 1123
Ser Gly Met Leu Met Arg Val Gln Leu Ala Leu Ser Ser Val Glu Arg
330 335 340
atc ttt gaa gtc att gat ctt cag cct gaa cgc acc gat cct gca cac 1171
Ile Phe Glu Val Ile Asp Leu Gln Pro Glu Arg Thr Asp Pro Ala His
345 350 355
ccc ctg tca ctt ccc gac act ccc ctg ggt ctg tcg ttc aac aac gta 1219
Pro Leu Ser Leu Pro Asp Thr Pro Leu Gly Leu Ser Phe Asn Asn Val
360 365 370
gat ttc cgt ggg att ctc aac ggt ttt gag ctg ggt gtt cag gcc ggt 1267
Asp Phe Arg Gly Ile Leu Asn Gly Phe Glu Leu Gly Val Gln Ala Gly
375 380 385
gaa acc gtt gtg ttg gtg ggc cct cca ggt tca ggc aag acc atg gct 1315
Glu Thr Val Val Leu Val Gly Pro Pro Gly Ser Gly Lys Thr Met Ala
390 395 400 405
gtg cag ctt gct gga aac ttt tat caa cca gac agc ggc cac atc gcc 1363
Val Gln Leu Ala Gly Asn Phe Tyr Gln Pro Asp Ser Gly His Ile Ala
410 415 420
ttt gat agc aac ggc cat cgc act cgc ttc gac gac ctc acc cac agc 1411
Phe Asp Ser Asn Gly His Arg Thr Arg Phe Asp Asp Leu Thr His Ser
425 430 435
gat atc cgc agg aat ctc atc gcg gtt ttt gat gag ccg ttc ttg tac 1459
Asp Ile Arg Arg Asn Leu Ile Ala Val Phe Asp Glu Pro Phe Leu Tyr
440 445 450
tcc tcc tcc ata ccg cga gaa cat ctc gat ggg ttt gga tgt cag 1504
Ser Ser Ser Ile Pro Arg Glu His Leu Asp Gly Phe Gly Cys Gln
455 460 465
tgatgagcag atcgaacacg cag 1527
<210> 324
<211> 468
<212> PRT
<213> Corynebacterium glutamicum
<400> 324
Met Lys Thr Glu Gln Ser Gln Lys Ala Gln Leu Ala Pro Lys Lys Ala
1 5 10 15
Pro Glu Lys Pro Gln Arg Ile Arg Gln Leu Ile Ser Val Ala Trp Gln
20 25 30
Arg Pro Trp Leu Thr Ser Phe Thr Val Ile Ser Ala Leu Ala Ala Thr
35 40 45
Leu Phe Glu Leu Thr Leu Pro Leu Leu Thr Gly Gly Ala Ile Asp Ile
50 55 60
Ala Leu Gly Asn Thr Gly Asp Thr Leu Thr Thr Asp Leu Leu Asp Arg
65 70 75 80
Phe Thr Pro Ser Gly Leu Ser Val Leu Thr Ser Val Ile Ala Leu Ile
85 90 95
Val Leu Leu Ala Leu Leu Arg Tyr Ala Ser Gln Phe Gly Arg Arg Tyr
100 105 110
Thr Ala Gly Lys Leu Ser Met Gly Val Gln His Asp Val Arg Leu Lys
115 120 125
Thr Met Arg Ser Leu Gln Asn Leu Asp Gly Pro Gly Gln Asp Ser Ile
130 135 140
Arg Thr Gly Gln Val Val Ser Arg Ser Ile Ser Asp Ile Asn Met Val
145 150 155 160
Gln Ser Leu Val Ala Met Leu Pro Met Leu Ile Gly Asn Val Val Lys
165 170 175
Leu Val Leu Thr Leu Val Ile Met Leu Ala Ile Ser Pro Pro Leu Thr
180 185 190
Ile Ile Ala Ala Val Leu Val Pro Leu Leu Leu Trp Ala Val Ala Tyr
195 200 205
Ser Arg Lys Ala Leu Phe Ala Ser Thr Trp Ser Ala Gln Gln Lys Ala
210 215 220
Ala Asp Leu Thr Thr His Val Glu Glu Thr Val Thr Gly Ile Arg Val
225 230 235 240
Val Lys Ala Phe Ala Gln Glu Asp Arg Glu Thr Asp Lys Leu Asp Leu
245 250 255
Thr Ala Arg Glu Leu Phe Ala Gln Arg Met Arg Thr Ala Arg Leu Thr
260 265 270
Ala Lys Phe Ile Pro Met Val Glu Gln Leu Pro Gln Leu Ala Leu Val
275 280 285
Val Asn Ile Val Gly Gly Gly Tyr Leu Ala Met Thr Gly His Ile Thr
290 295 300
Val Gly Thr Phe Val Ala Phe Ser Ser Tyr Leu Thr Ser Leu Ser Ala
305 310 315 320
Val Ala Arg Ser Leu Ser Gly Met Leu Met Arg Val Gln Leu Ala Leu
325 330 335
Ser Ser Val Glu Arg Ile Phe Glu Val Ile Asp Leu Gln Pro Glu Arg
340 345 350
Thr Asp Pro Ala His Pro Leu Ser Leu Pro Asp Thr Pro Leu Gly Leu
355 360 365
Ser Phe Asn Asn Val Asp Phe Arg Gly Ile Leu Asn Gly Phe Glu Leu
370 375 380
Gly Val Gln Ala Gly Glu Thr Val Val Leu Val Gly Pro Pro Gly Ser
385 390 395 400
Gly Lys Thr Met Ala Val Gln Leu Ala Gly Asn Phe Tyr Gln Pro Asp
405 410 415
Ser Gly His Ile Ala Phe Asp Ser Asn Gly His Arg Thr Arg Phe Asp
420 425 430
Asp Leu Thr His Ser Asp Ile Arg Arg Asn Leu Ile Ala Val Phe Asp
435 440 445
Glu Pro Phe Leu Tyr Ser Ser Ser Ile Pro Arg Glu His Leu Asp Gly
450 455 460
Phe Gly Cys Gln
465
<210> 325
<211> 905
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(882)
<223> RXA02225
<400> 325
caa act gag gag cgc ttt ggc gca gcg gct gat gaa gcc ttg gca atc 48
Gln Thr Glu Glu Arg Phe Gly Ala Ala Ala Asp Glu Ala Leu Ala Ile
1 5 10 15
atg ttg aag gaa gct cgt ctg cag tcg ttg ctg act ttt gtg cgc caa 96
Met Leu Lys Glu Ala Arg Leu Gln Ser Leu Leu Thr Phe Val Arg Gln
20 25 30
ctt gtc cca gcg gtg ttt tct gtg ggt ctt ttg gct tat gcg tca ctg 144
Leu Val Pro Ala Val Phe Ser Val Gly Leu Leu Ala Tyr Ala Ser Leu
35 40 45
ttg gct ttt gac ggt gac ata act ggt ggt gag atg atc tcg gtg acg 192
Leu Ala Phe Asp Gly Asp Ile Thr Gly Gly Glu Met Ile Ser Val Thr
50 55 60
ttg ctg gtg cca cct tcg ttg act gtg ttg ggt gtg tcg ctt ggc atg 240
Leu Leu Val Pro Pro Ser Leu Thr Val Leu Gly Val Ser Leu Gly Met
65 70 75 80
atg aca gag att tgg gct agg gga cag gct tcg aca aaa agg gtc caa 288
Met Thr Glu Ile Trp Ala Arg Gly Gln Ala Ser Thr Lys Arg Val Gln
85 90 95
aac tta gtc act gaa ctg gat aag gcg gcc gct gag cca cga cct cag 336
Asn Leu Val Thr Glu Leu Asp Lys Ala Ala Ala Glu Pro Arg Pro Gln
100 105 110
cct gcc acc ttt gaa ttt gaa gag ggg atc acg gtg tgg gat cct tcg 384
Pro Ala Thr Phe Glu Phe Glu Glu Gly Ile Thr Val Trp Asp Pro Ser
115 120 125
aca cct gag gca cgc gat gtg att gat cgg gag ttg gag gcg ctt cag 432
Thr Pro Glu Ala Arg Asp Val Ile Asp Arg Glu Leu Glu Ala Leu Gln
130 135 140
gtt cgc gaa gat gtc att gtg gct cct cac cgc gtc agc gtg ttt gaa 480
Val Arg Glu Asp Val Ile Val Ala Pro His Arg Val Ser Val Phe Glu
145 150 155 160
ggt gtg ctg aag gat aat ttg aat ccg atg ggc act atc gca ccg gag 528
Gly Val Leu Lys Asp Asn Leu Asn Pro Met Gly Thr Ile Ala Pro Glu
165 170 175
atg ctg cgc gct gct ctt cat gct gca agt tgt gag gac atc ttg agc 576
Met Leu Arg Ala Ala Leu His Ala Ala Ser Cys Glu Asp Ile Leu Ser
180 185 190
cga ttg ggt gct gat ctg aac atg ccg ggg gag ttt gag ctt cca gat 624
Arg Leu Gly Ala Asp Leu Asn Met Pro Gly Glu Phe Glu Leu Pro Asp
195 200 205
acc ttg atc ggc gag gcc gga ttg aat ctc tcc ggt ggc caa cgc cag 672
Thr Leu Ile Gly Glu Ala Gly Leu Asn Leu Ser Gly Gly Gln Arg Gln
210 215 220
agg att gct ttg gca cga ttc ttg gct gtt gat cct gag gtg ctc att 720
Arg Ile Ala Leu Ala Arg Phe Leu Ala Val Asp Pro Glu Val Leu Ile
225 230 235 240
ttg gat gaa ccg acc acg ggg ttg gat gcg gtg acc ctg gat gaa gtg 768
Leu Asp Glu Pro Thr Thr Gly Leu Asp Ala Val Thr Leu Asp Glu Val
245 250 255
gca cat cgc gtc gaa aag ctt cgt cga ggc cgg aaa acc gtc gtc att 816
Ala His Arg Val Glu Lys Leu Arg Arg Gly Arg Lys Thr Val Val Ile
260 265 270
acg tcg aac ccg acg tgg cac ggc gtc gca aag cag atg caa tct gat 864
Thr Ser Asn Pro Thr Trp His Gly Val Ala Lys Gln Met Gln Ser Asp
275 280 285
ttt tcg gaa ggg gtg aag tagatggcgc agcatgagcg cgt 905
Phe Ser Glu Gly Val Lys
290
<210> 326
<211> 294
<212> PRT
<213> Corynebacterium glutamicum
<400> 326
Gln Thr Glu Glu Arg Phe Gly Ala Ala Ala Asp Glu Ala Leu Ala Ile
1 5 10 15
Met Leu Lys Glu Ala Arg Leu Gln Ser Leu Leu Thr Phe Val Arg Gln
20 25 30
Leu Val Pro Ala Val Phe Ser Val Gly Leu Leu Ala Tyr Ala Ser Leu
35 40 45
Leu Ala Phe Asp Gly Asp Ile Thr Gly Gly Glu Met Ile Ser Val Thr
50 55 60
Leu Leu Val Pro Pro Ser Leu Thr Val Leu Gly Val Ser Leu Gly Met
65 70 75 80
Met Thr Glu Ile Trp Ala Arg Gly Gln Ala Ser Thr Lys Arg Val Gln
85 90 95
Asn Leu Val Thr Glu Leu Asp Lys Ala Ala Ala Glu Pro Arg Pro Gln
100 105 110
Pro Ala Thr Phe Glu Phe Glu Glu Gly Ile Thr Val Trp Asp Pro Ser
115 120 125
Thr Pro Glu Ala Arg Asp Val Ile Asp Arg Glu Leu Glu Ala Leu Gln
130 135 140
Val Arg Glu Asp Val Ile Val Ala Pro His Arg Val Ser Val Phe Glu
145 150 155 160
Gly Val Leu Lys Asp Asn Leu Asn Pro Met Gly Thr Ile Ala Pro Glu
165 170 175
Met Leu Arg Ala Ala Leu His Ala Ala Ser Cys Glu Asp Ile Leu Ser
180 185 190
Arg Leu Gly Ala Asp Leu Asn Met Pro Gly Glu Phe Glu Leu Pro Asp
195 200 205
Thr Leu Ile Gly Glu Ala Gly Leu Asn Leu Ser Gly Gly Gln Arg Gln
210 215 220
Arg Ile Ala Leu Ala Arg Phe Leu Ala Val Asp Pro Glu Val Leu Ile
225 230 235 240
Leu Asp Glu Pro Thr Thr Gly Leu Asp Ala Val Thr Leu Asp Glu Val
245 250 255
Ala His Arg Val Glu Lys Leu Arg Arg Gly Arg Lys Thr Val Val Ile
260 265 270
Thr Ser Asn Pro Thr Trp His Gly Val Ala Lys Gln Met Gln Ser Asp
275 280 285
Phe Ser Glu Gly Val Lys
290
<210> 327
<211> 1050
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1027)
<223> RXA02253
<400> 327
tgaggacatt tcccaagtga aaggcttcgg cccgaaactt gcggaggctg tctatgaagg 60
tcttcacgcg tcaaaataag tagatcgcta ggatgtaacc atg att caa tcc act 115
Met Ile Gln Ser Thr
1 5
ggg gtc acg cac act gat aag tct gca caa gaa aat cct gtg aag tac 163
Gly Val Thr His Thr Asp Lys Ser Ala Gln Glu Asn Pro Val Lys Tyr
10 15 20
agg gac aat ttc aca cct gtc atc atc acc ggt atg tca ggc gca ggt 211
Arg Asp Asn Phe Thr Pro Val Ile Ile Thr Gly Met Ser Gly Ala Gly
25 30 35
ctg agc aca gca gcc cga gtc ctc gaa gac ttg ggt tgg tat gtg gcg 259
Leu Ser Thr Ala Ala Arg Val Leu Glu Asp Leu Gly Trp Tyr Val Ala
40 45 50
cac aat att cca cca cag atc atc ctg gaa tta att gat atg tgc gct 307
His Asn Ile Pro Pro Gln Ile Ile Leu Glu Leu Ile Asp Met Cys Ala
55 60 65
cgg gaa gat tct ccc gtc gac aaa gtt gca gtc gtg tgc gat gtg cgc 355
Arg Glu Asp Ser Pro Val Asp Lys Val Ala Val Val Cys Asp Val Arg
70 75 80 85
tcc cgt gaa ttc cgc gga agc ctc acc cag gtt gtt tca gag ctg cgt 403
Ser Arg Glu Phe Arg Gly Ser Leu Thr Gln Val Val Ser Glu Leu Arg
90 95 100
gat aag cag ctc gat ccc acg gtg tta ttt ctg gaa gca cgc gat gag 451
Asp Lys Gln Leu Asp Pro Thr Val Leu Phe Leu Glu Ala Arg Asp Glu
105 110 115
gtg ctg atc aag cga ttc gat aat gtg cgc cgc acc cat cct ttg cag 499
Val Leu Ile Lys Arg Phe Asp Asn Val Arg Arg Thr His Pro Leu Gln
120 125 130
ggc agc caa acc ctt cag gtg ggt att gaa cgt gaa cga acc gtg ctg 547
Gly Ser Gln Thr Leu Gln Val Gly Ile Glu Arg Glu Arg Thr Val Leu
135 140 145
tct cct gtg aag gaa gac gct tca gtg gtc atc gat acc tcg gat ctg 595
Ser Pro Val Lys Glu Asp Ala Ser Val Val Ile Asp Thr Ser Asp Leu
150 155 160 165
tcc gtg cat gat ttg cgc cgc gcc atc gaa tcc tcg ttt agg aca atc 643
Ser Val His Asp Leu Arg Arg Ala Ile Glu Ser Ser Phe Arg Thr Ile
170 175 180
gcc acg cgc acc cag cac gtc acc att gaa tca ttc ggt ttc aaa cac 691
Ala Thr Arg Thr Gln His Val Thr Ile Glu Ser Phe Gly Phe Lys His
185 190 195
ggc tca cca cgc gac gcc gac ttt gtt gtg gac gtg cgt ttc ttg ccg 739
Gly Ser Pro Arg Asp Ala Asp Phe Val Val Asp Val Arg Phe Leu Pro
200 205 210
aac cca ttc tgg gtt cca gag ctg cgc cca ttt agg gga gtg gac aag 787
Asn Pro Phe Trp Val Pro Glu Leu Arg Pro Phe Arg Gly Val Asp Lys
215 220 225
cca gta tct gac tat gtg ctc tcc caa aaa ggc gca gaa gaa ttt ttg 835
Pro Val Ser Asp Tyr Val Leu Ser Gln Lys Gly Ala Glu Glu Phe Leu
230 235 240 245
aac aac ttt gtg gac atg ctc aaa gac atg ctt ccg gga tac cgc cac 883
Asn Asn Phe Val Asp Met Leu Lys Asp Met Leu Pro Gly Tyr Arg His
250 255 260
gaa gga aaa aac ttc atc aca atc ggt gtc ggc tgc acc ggt gga cac 931
Glu Gly Lys Asn Phe Ile Thr Ile Gly Val Gly Cys Thr Gly Gly His
265 270 275
cac aga tca gtt gcg gtg tct gaa gaa cta gcc aaa aga atc gca gat 979
His Arg Ser Val Ala Val Ser Glu Glu Leu Ala Lys Arg Ile Ala Asp
280 285 290
cag acc acg ctc gac gtg tct gta gta cac cgc gat att aac cgc cac 1027
Gln Thr Thr Leu Asp Val Ser Val Val His Arg Asp Ile Asn Arg His
295 300 305
taggaaaggg gccaactaat tga 1050
<210> 328
<211> 309
<212> PRT
<213> Corynebacterium glutamicum
<400> 328
Met Ile Gln Ser Thr Gly Val Thr His Thr Asp Lys Ser Ala Gln Glu
1 5 10 15
Asn Pro Val Lys Tyr Arg Asp Asn Phe Thr Pro Val Ile Ile Thr Gly
20 25 30
Met Ser Gly Ala Gly Leu Ser Thr Ala Ala Arg Val Leu Glu Asp Leu
35 40 45
Gly Trp Tyr Val Ala His Asn Ile Pro Pro Gln Ile Ile Leu Glu Leu
50 55 60
Ile Asp Met Cys Ala Arg Glu Asp Ser Pro Val Asp Lys Val Ala Val
65 70 75 80
Val Cys Asp Val Arg Ser Arg Glu Phe Arg Gly Ser Leu Thr Gln Val
85 90 95
Val Ser Glu Leu Arg Asp Lys Gln Leu Asp Pro Thr Val Leu Phe Leu
100 105 110
Glu Ala Arg Asp Glu Val Leu Ile Lys Arg Phe Asp Asn Val Arg Arg
115 120 125
Thr His Pro Leu Gln Gly Ser Gln Thr Leu Gln Val Gly Ile Glu Arg
130 135 140
Glu Arg Thr Val Leu Ser Pro Val Lys Glu Asp Ala Ser Val Val Ile
145 150 155 160
Asp Thr Ser Asp Leu Ser Val His Asp Leu Arg Arg Ala Ile Glu Ser
165 170 175
Ser Phe Arg Thr Ile Ala Thr Arg Thr Gln His Val Thr Ile Glu Ser
180 185 190
Phe Gly Phe Lys His Gly Ser Pro Arg Asp Ala Asp Phe Val Val Asp
195 200 205
Val Arg Phe Leu Pro Asn Pro Phe Trp Val Pro Glu Leu Arg Pro Phe
210 215 220
Arg Gly Val Asp Lys Pro Val Ser Asp Tyr Val Leu Ser Gln Lys Gly
225 230 235 240
Ala Glu Glu Phe Leu Asn Asn Phe Val Asp Met Leu Lys Asp Met Leu
245 250 255
Pro Gly Tyr Arg His Glu Gly Lys Asn Phe Ile Thr Ile Gly Val Gly
260 265 270
Cys Thr Gly Gly His His Arg Ser Val Ala Val Ser Glu Glu Leu Ala
275 280 285
Lys Arg Ile Ala Asp Gln Thr Thr Leu Asp Val Ser Val Val His Arg
290 295 300
Asp Ile Asn Arg His
305
<210> 329
<211> 558
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(535)
<223> RXN01881
<400> 329
accggccctg cggcctcaac cgccgaccag cgcggcgcac acattttgac tgtttcataa 60
taaagacaaa cttaagtatc ggagtcgaag aaaaaccaca atg gcc aat ctg att 115
Met Ala Asn Leu Ile
1 5
aat ctc gag aac gtc tcc aaa acc tgg gga tta aaa acg ctt ctc gac 163
Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu Lys Thr Leu Leu Asp
10 15 20
ggt gtc tcc tta ggt gtt caa acc ggc gac cgc att ggc gtc gtc ggc 211
Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg Ile Gly Val Val Gly
25 30 35
ctc aat ggt ggc gga aaa acc acc ctg ctg gaa gta ctt act ggc atc 259
Leu Asn Gly Gly Gly Lys Thr Thr Leu Leu Glu Val Leu Thr Gly Ile
40 45 50
gaa aag ccg gat cag ggc cgt gtg tct cac aac tct gac ctg cgc atg 307
Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn Ser Asp Leu Arg Met
55 60 65
gct gtg gtg acg cag cgt gct gaa ctc aat gat gac gac acc gtc gct 355
Ala Val Val Thr Gln Arg Ala Glu Leu Asn Asp Asp Asp Thr Val Ala
70 75 80 85
gac gtg gtg ctt gga cct ttg ggt ttg gaa gtt ttc gaa tgg gca tca 403
Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val Phe Glu Trp Ala Ser
90 95 100
aac gcc acg gtg cgc gac gtc ctc ggt ggc ttg ggc att gtc gat ctt 451
Asn Ala Thr Val Arg Asp Val Leu Gly Gly Leu Gly Ile Val Asp Leu
105 110 115
ggc ctt gac acc aag gtg ggc aaa cct ttt ccg gtg ggc gaa gcg ccg 499
Gly Leu Asp Thr Lys Val Gly Lys Pro Phe Pro Val Gly Glu Ala Pro
120 125 130
acg cac caa cct ggc cgc cgc gct ggt tcg cga cct tgacctgatc 545
Thr His Gln Pro Gly Arg Arg Ala Gly Ser Arg Pro
135 140 145
gtgctcgacg agc 558
<210> 330
<211> 145
<212> PRT
<213> Corynebacterium glutamicum
<400> 330
Met Ala Asn Leu Ile Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu
1 5 10 15
Lys Thr Leu Leu Asp Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg
20 25 30
Ile Gly Val Val Gly Leu Asn Gly Gly Gly Lys Thr Thr Leu Leu Glu
35 40 45
Val Leu Thr Gly Ile Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn
50 55 60
Ser Asp Leu Arg Met Ala Val Val Thr Gln Arg Ala Glu Leu Asn Asp
65 70 75 80
Asp Asp Thr Val Ala Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val
85 90 95
Phe Glu Trp Ala Ser Asn Ala Thr Val Arg Asp Val Leu Gly Gly Leu
100 105 110
Gly Ile Val Asp Leu Gly Leu Asp Thr Lys Val Gly Lys Pro Phe Pro
115 120 125
Val Gly Glu Ala Pro Thr His Gln Pro Gly Arg Arg Ala Gly Ser Arg
130 135 140
Pro
145
<210> 331
<211> 564
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(541)
<223> FRXA01881
<400> 331
accggccctg cggcctcaac cgccgaccag cgcggcgcac acattttgac tgtttcataa 60
taaagacaaa cttaagtatc ggagtcgaag aaaaaccaca atg gcc aat ctg att 115
Met Ala Asn Leu Ile
1 5
aat ctc gag aac gtc tcc aaa acc tgg gga tta aaa acg ctt ctc gac 163
Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu Lys Thr Leu Leu Asp
10 15 20
ggt gtc tcc tta ggt gtt caa acc ggc gac cgc att ggc gtc gtc ggc 211
Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg Ile Gly Val Val Gly
25 30 35
ctc aat ggt ggc gga aaa acc acc ctg ctg gaa gta ctt act ggc atc 259
Leu Asn Gly Gly Gly Lys Thr Thr Leu Leu Glu Val Leu Thr Gly Ile
40 45 50
gaa aag ccg gat cag ggc cgt gtg tct cac aac tct gac ctg cgc atg 307
Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn Ser Asp Leu Arg Met
55 60 65
gct gtg gtg acg cag cgt gct gaa ctc aat gat gac gac acc gtc gct 355
Ala Val Val Thr Gln Arg Ala Glu Leu Asn Asp Asp Asp Thr Val Ala
70 75 80 85
gac gtg gtg ctt gga cct ttg ggt ttg gaa gtt ttc gaa tgg gca tca 403
Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val Phe Glu Trp Ala Ser
90 95 100
aac gcc acg gtg cgc gac gtc ctc ggt ggc ttg ggc att gtc gat ctt 451
Asn Ala Thr Val Arg Asp Val Leu Gly Gly Leu Gly Ile Val Asp Leu
105 110 115
ggc ctt gac acc aag gtg ggg caa acc ttt tcc ggt ggg cga agc gcc 499
Gly Leu Asp Thr Lys Val Gly Gln Thr Phe Ser Gly Gly Arg Ser Ala
120 125 130
gac gca cca acc tgg ccg ccg cgc tgg ttc gcg acc ttg acc 541
Asp Ala Pro Thr Trp Pro Pro Arg Trp Phe Ala Thr Leu Thr
135 140 145
tgatcgtgct cgacgagccc acc 564
<210> 332
<211> 147
<212> PRT
<213> Corynebacterium glutamicum
<400> 332
Met Ala Asn Leu Ile Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu
1 5 10 15
Lys Thr Leu Leu Asp Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg
20 25 30
Ile Gly Val Val Gly Leu Asn Gly Gly Gly Lys Thr Thr Leu Leu Glu
35 40 45
Val Leu Thr Gly Ile Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn
50 55 60
Ser Asp Leu Arg Met Ala Val Val Thr Gln Arg Ala Glu Leu Asn Asp
65 70 75 80
Asp Asp Thr Val Ala Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val
85 90 95
Phe Glu Trp Ala Ser Asn Ala Thr Val Arg Asp Val Leu Gly Gly Leu
100 105 110
Gly Ile Val Asp Leu Gly Leu Asp Thr Lys Val Gly Gln Thr Phe Ser
115 120 125
Gly Gly Arg Ser Ala Asp Ala Pro Thr Trp Pro Pro Arg Trp Phe Ala
130 135 140
Thr Leu Thr
145
<210> 333
<211> 813
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(790)
<223> RXA00526
<400> 333
ggtggagcag gcggcggctc cttttagtcc tgcggcccct tttgaccctg cagcccctgc 60
cgtttctgcc aagcaaaccg tgggccaggt gatttagcct atg agc ctc atc gaa 115
Met Ser Leu Ile Glu
1 5
atg cga aat att gtc aag acc tac aac att gga tct gaa ggt gaa ctc 163
Met Arg Asn Ile Val Lys Thr Tyr Asn Ile Gly Ser Glu Gly Glu Leu
10 15 20
acc gtg ttg cac ggt gtg gat ttc cat gtg gac cgt ggc gaa ttc gtg 211
Thr Val Leu His Gly Val Asp Phe His Val Asp Arg Gly Glu Phe Val
25 30 35
tcg gtt gtg ggt acg tcc ggc tca ggt aaa tca acg atg atg aac atc 259
Ser Val Val Gly Thr Ser Gly Ser Gly Lys Ser Thr Met Met Asn Ile
40 45 50
att ggg ttg ttg gat aag cca act gat ggc acg tac acc ttg gat ggc 307
Ile Gly Leu Leu Asp Lys Pro Thr Asp Gly Thr Tyr Thr Leu Asp Gly
55 60 65
gtg gat gtg ttg gat atc agc gat gat gct ttg gcg agc cac cgc gct 355
Val Asp Val Leu Asp Ile Ser Asp Asp Ala Leu Ala Ser His Arg Ala
70 75 80 85
aaa tcg att ggt ttt gtg ttt cag aac ttc aat ctg att ggc cgg atc 403
Lys Ser Ile Gly Phe Val Phe Gln Asn Phe Asn Leu Ile Gly Arg Ile
90 95 100
gat gcg ttg aag aat gtg gaa atg ccc atg atg tat gcg ggc att ccg 451
Asp Ala Leu Lys Asn Val Glu Met Pro Met Met Tyr Ala Gly Ile Pro
105 110 115
gct aag cag cgg aga agt cgt gcg gtt gaa tta ttg gaa atg gtc ggg 499
Ala Lys Gln Arg Arg Ser Arg Ala Val Glu Leu Leu Glu Met Val Gly
120 125 130
atg ggt gag cgt ctc aac cat gag ccc aat gag ctt tcg ggt ggt cag 547
Met Gly Glu Arg Leu Asn His Glu Pro Asn Glu Leu Ser Gly Gly Gln
135 140 145
aag cag cgc gtg gcc att gct cgc gcg ttg gcg aac gat cct gag atc 595
Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ala Asn Asp Pro Glu Ile
150 155 160 165
att ctt gct gat gaa cca act ggt gcg ttg gat tct gca acg ggc cgg 643
Ile Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp Ser Ala Thr Gly Arg
170 175 180
atg gtg atg gat att ttc cac cag ctc aac aag gag cag ggc aaa acc 691
Met Val Met Asp Ile Phe His Gln Leu Asn Lys Glu Gln Gly Lys Thr
185 190 195
atc gtg ttt att act cac aac cct gag ctt gct gat gaa tct gat cgg 739
Ile Val Phe Ile Thr His Asn Pro Glu Leu Ala Asp Glu Ser Asp Arg
200 205 210
gtg gtc acc atg gtt gac ggg cgc atc att ggg tct gag gtg aaa cac 787
Val Val Thr Met Val Asp Gly Arg Ile Ile Gly Ser Glu Val Lys His
215 220 225
tca tgagccttgc agaatcaatt ctt 813
Ser
230
<210> 334
<211> 230
<212> PRT
<213> Corynebacterium glutamicum
<400> 334
Met Ser Leu Ile Glu Met Arg Asn Ile Val Lys Thr Tyr Asn Ile Gly
1 5 10 15
Ser Glu Gly Glu Leu Thr Val Leu His Gly Val Asp Phe His Val Asp
20 25 30
Arg Gly Glu Phe Val Ser Val Val Gly Thr Ser Gly Ser Gly Lys Ser
35 40 45
Thr Met Met Asn Ile Ile Gly Leu Leu Asp Lys Pro Thr Asp Gly Thr
50 55 60
Tyr Thr Leu Asp Gly Val Asp Val Leu Asp Ile Ser Asp Asp Ala Leu
65 70 75 80
Ala Ser His Arg Ala Lys Ser Ile Gly Phe Val Phe Gln Asn Phe Asn
85 90 95
Leu Ile Gly Arg Ile Asp Ala Leu Lys Asn Val Glu Met Pro Met Met
100 105 110
Tyr Ala Gly Ile Pro Ala Lys Gln Arg Arg Ser Arg Ala Val Glu Leu
115 120 125
Leu Glu Met Val Gly Met Gly Glu Arg Leu Asn His Glu Pro Asn Glu
130 135 140
Leu Ser Gly Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ala
145 150 155 160
Asn Asp Pro Glu Ile Ile Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp
165 170 175
Ser Ala Thr Gly Arg Met Val Met Asp Ile Phe His Gln Leu Asn Lys
180 185 190
Glu Gln Gly Lys Thr Ile Val Phe Ile Thr His Asn Pro Glu Leu Ala
195 200 205
Asp Glu Ser Asp Arg Val Val Thr Met Val Asp Gly Arg Ile Ile Gly
210 215 220
Ser Glu Val Lys His Ser
225 230
<210> 335
<211> 1008
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(985)
<223> RXN00733
<400> 335
acggcgaggt tgtcggtatt ggaacgcaca cgaatttgct gaacacgtgc ggtacctacc 60
gtgaaattgt tgaatcccaa gagactgcgc aggcgcaatc atg agt aat act gca 115
Met Ser Asn Thr Ala
1 5
ggc ccc cgc ggg cgt tcc cat cag gca gac gcc gcg ccg aat caa aag 163
Gly Pro Arg Gly Arg Ser His Gln Ala Asp Ala Ala Pro Asn Gln Lys
10 15 20
gca cag aat ttc gga cca tct gcc aaa agg ctt ttc gga att cta ggc 211
Ala Gln Asn Phe Gly Pro Ser Ala Lys Arg Leu Phe Gly Ile Leu Gly
25 30 35
cat gac cgt aac acc tta att ttt gtt atc ttc cta gcc gtc ctg agc 259
His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe Leu Ala Val Leu Ser
40 45 50
gtt gga ctt acc gtc ttg ggc cca tgg ttg ctg ggt aaa gcc acc aac 307
Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu Gly Lys Ala Thr Asn
55 60 65
gtg gtg ttt gaa gga ttc cta tct aag cgc atg ccg gct ggt gcg tca 355
Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met Pro Ala Gly Ala Ser
70 75 80 85
aag gaa gat atc atc gcg cag ttg cag gct gca ggt aaa cat aat cag 403
Lys Glu Asp Ile Ile Ala Gln Leu Gln Ala Ala Gly Lys His Asn Gln
90 95 100
gct tcc atg atg gaa gac atg aac ctt gtt cca ggc tca ggc att gat 451
Ala Ser Met Met Glu Asp Met Asn Leu Val Pro Gly Ser Gly Ile Asp
105 110 115
ttt gaa aaa tta gcc atg atc ctc gga ctg gtg atc ggt gct tat ctc 499
Phe Glu Lys Leu Ala Met Ile Leu Gly Leu Val Ile Gly Ala Tyr Leu
120 125 130
atc ggt agc ctg ttg tcg ttg ttc cag gcg cgg atg ctc aac cgc atc 547
Ile Gly Ser Leu Leu Ser Leu Phe Gln Ala Arg Met Leu Asn Arg Ile
135 140 145
gtg caa agt gcc atg cac cgg ctg cgc atg gag gtg gag gaa aaa atc 595
Val Gln Ser Ala Met His Arg Leu Arg Met Glu Val Glu Glu Lys Ile
150 155 160 165
cac cgc cta ccg ctg agc tat ttc gat tcc atc aaa cgt ggt gat ctg 643
His Arg Leu Pro Leu Ser Tyr Phe Asp Ser Ile Lys Arg Gly Asp Leu
170 175 180
ctt agc cgt gtg acc aac gat gtg gat aat atc ggt caa tcc ctg caa 691
Leu Ser Arg Val Thr Asn Asp Val Asp Asn Ile Gly Gln Ser Leu Gln
185 190 195
caa acc ttg tca cag gcg atc act tcc cta ctg acc gtc atc ggt gtg 739
Gln Thr Leu Ser Gln Ala Ile Thr Ser Leu Leu Thr Val Ile Gly Val
200 205 210
ttg gtg atg atg ttt atc atc tcc cca ctg ctc gca ctc gtg gcg ctg 787
Leu Val Met Met Phe Ile Ile Ser Pro Leu Leu Ala Leu Val Ala Leu
215 220 225
gta tcc att ccg gtc acc atc gtg gtc act gtg gtg gtt gcg agc cgt 835
Val Ser Ile Pro Val Thr Ile Val Val Thr Val Val Val Ala Ser Arg
230 235 240 245
tcc cag aaa ctc ttt gcg gaa cag tgg aag cag acc ggt att ttg aat 883
Ser Gln Lys Leu Phe Ala Glu Gln Trp Lys Gln Thr Gly Ile Leu Asn
250 255 260
gcg cgc ctg gag gaa acc tac tct ggc cac gcc gtg gtt aag gtt ttc 931
Ala Arg Leu Glu Glu Thr Tyr Ser Gly His Ala Val Val Lys Val Phe
265 270 275
gga cac caa aag gat gtt caa gaa gca ttc gag gaa gaa aat caa gct 979
Gly His Gln Lys Asp Val Gln Glu Ala Phe Glu Glu Glu Asn Gln Ala
280 285 290
tgt gta taaggccagc tttggtgccc agt 1008
Cys Val
295
<210> 336
<211> 295
<212> PRT
<213> Corynebacterium glutamicum
<400> 336
Met Ser Asn Thr Ala Gly Pro Arg Gly Arg Ser His Gln Ala Asp Ala
1 5 10 15
Ala Pro Asn Gln Lys Ala Gln Asn Phe Gly Pro Ser Ala Lys Arg Leu
20 25 30
Phe Gly Ile Leu Gly His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe
35 40 45
Leu Ala Val Leu Ser Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu
50 55 60
Gly Lys Ala Thr Asn Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met
65 70 75 80
Pro Ala Gly Ala Ser Lys Glu Asp Ile Ile Ala Gln Leu Gln Ala Ala
85 90 95
Gly Lys His Asn Gln Ala Ser Met Met Glu Asp Met Asn Leu Val Pro
100 105 110
Gly Ser Gly Ile Asp Phe Glu Lys Leu Ala Met Ile Leu Gly Leu Val
115 120 125
Ile Gly Ala Tyr Leu Ile Gly Ser Leu Leu Ser Leu Phe Gln Ala Arg
130 135 140
Met Leu Asn Arg Ile Val Gln Ser Ala Met His Arg Leu Arg Met Glu
145 150 155 160
Val Glu Glu Lys Ile His Arg Leu Pro Leu Ser Tyr Phe Asp Ser Ile
165 170 175
Lys Arg Gly Asp Leu Leu Ser Arg Val Thr Asn Asp Val Asp Asn Ile
180 185 190
Gly Gln Ser Leu Gln Gln Thr Leu Ser Gln Ala Ile Thr Ser Leu Leu
195 200 205
Thr Val Ile Gly Val Leu Val Met Met Phe Ile Ile Ser Pro Leu Leu
210 215 220
Ala Leu Val Ala Leu Val Ser Ile Pro Val Thr Ile Val Val Thr Val
225 230 235 240
Val Val Ala Ser Arg Ser Gln Lys Leu Phe Ala Glu Gln Trp Lys Gln
245 250 255
Thr Gly Ile Leu Asn Ala Arg Leu Glu Glu Thr Tyr Ser Gly His Ala
260 265 270
Val Val Lys Val Phe Gly His Gln Lys Asp Val Gln Glu Ala Phe Glu
275 280 285
Glu Glu Asn Gln Ala Cys Val
290 295
<210> 337
<211> 508
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(508)
<223> FRXA00733
<400> 337
acggcgaggt tgtcggtatt ggaacgcaca cgaatttgct gaacacgtgc ggtacctacc 60
gtgaaattgt tgaatcccaa gagactgcgc aggcgcaatc atg agt aat act gca 115
Met Ser Asn Thr Ala
1 5
ggc ccc cgc ggg cgt tcc cat cag gca gac gcc gcg ccg aat caa aag 163
Gly Pro Arg Gly Arg Ser His Gln Ala Asp Ala Ala Pro Asn Gln Lys
10 15 20
gca cag aat ttc gga cca tct gcc aaa agg ctt ttc gga att cta ggc 211
Ala Gln Asn Phe Gly Pro Ser Ala Lys Arg Leu Phe Gly Ile Leu Gly
25 30 35
cat gac cgt aac acc tta att ttt gtt atc ttc cta gcc gtc ctg agc 259
His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe Leu Ala Val Leu Ser
40 45 50
gtt gga ctt acc gtc ttg ggc cca tgg ttg ctg ggt aaa gcc acc aac 307
Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu Gly Lys Ala Thr Asn
55 60 65
gtg gtg ttt gaa gga ttc cta tct aag cgc atg ccg gct ggt gcg tca 355
Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met Pro Ala Gly Ala Ser
70 75 80 85
aag gaa gat atc atc gcg cag ttg cag gct gca ggt aaa cat aat cag 403
Lys Glu Asp Ile Ile Ala Gln Leu Gln Ala Ala Gly Lys His Asn Gln
90 95 100
gct tcc atg atg gaa gac atg aac ctt gtt cca ggc tca ggc att gat 451
Ala Ser Met Met Glu Asp Met Asn Leu Val Pro Gly Ser Gly Ile Asp
105 110 115
ttt gaa aaa tta gcc atg atc ctc gga ctg gtg atc ggt gct tat ctc 499
Phe Glu Lys Leu Ala Met Ile Leu Gly Leu Val Ile Gly Ala Tyr Leu
120 125 130
att cgt agc 508
Ile Arg Ser
135
<210> 338
<211> 136
<212> PRT
<213> Corynebacterium glutamicum
<400> 338
Met Ser Asn Thr Ala Gly Pro Arg Gly Arg Ser His Gln Ala Asp Ala
1 5 10 15
Ala Pro Asn Gln Lys Ala Gln Asn Phe Gly Pro Ser Ala Lys Arg Leu
20 25 30
Phe Gly Ile Leu Gly His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe
35 40 45
Leu Ala Val Leu Ser Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu
50 55 60
Gly Lys Ala Thr Asn Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met
65 70 75 80
Pro Ala Gly Ala Ser Lys Glu Asp Ile Ile Ala Gln Leu Gln Ala Ala
85 90 95
Gly Lys His Asn Gln Ala Ser Met Met Glu Asp Met Asn Leu Val Pro
100 105 110
Gly Ser Gly Ile Asp Phe Glu Lys Leu Ala Met Ile Leu Gly Leu Val
115 120 125
Ile Gly Ala Tyr Leu Ile Arg Ser
130 135
<210> 339
<211> 692
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(669)
<223> RXA00735
<400> 339
ggt ccc acc ggt gcg ggc aag acc aca ttg gtg aat ctg atc atg cgt 48
Gly Pro Thr Gly Ala Gly Lys Thr Thr Leu Val Asn Leu Ile Met Arg
1 5 10 15
ttc tac gac atc aac agc ggt tcc atc act ctt ggt gaa aca gca caa 96
Phe Tyr Asp Ile Asn Ser Gly Ser Ile Thr Leu Gly Glu Thr Ala Gln
20 25 30
gac gcc gtg gat atc cgc acc atg gct aga gaa gat ctg cga tca cga 144
Asp Ala Val Asp Ile Arg Thr Met Ala Arg Glu Asp Leu Arg Ser Arg
35 40 45
acc ggc atg gtg ttg cag gat acg tgg ctg ttt gcc gga acc atc agg 192
Thr Gly Met Val Leu Gln Asp Thr Trp Leu Phe Ala Gly Thr Ile Arg
50 55 60
gat aac att ctt tac ggt aga cct gaa gca act gag gaa gaa atg ctt 240
Asp Asn Ile Leu Tyr Gly Arg Pro Glu Ala Thr Glu Glu Glu Met Leu
65 70 75 80
gct gcg tcc aag gcc gcc tac gtg gat cgt ttt gtc cgt tcc ctg cca 288
Ala Ala Ser Lys Ala Ala Tyr Val Asp Arg Phe Val Arg Ser Leu Pro
85 90 95
gaa ggc tac gac acc gta ctt gat gat gaa gcc atg aac cta tcg gtg 336
Glu Gly Tyr Asp Thr Val Leu Asp Asp Glu Ala Met Asn Leu Ser Val
100 105 110
ggt gaa cgc cag ctg atc acc atc gcg cgt gca ttc ttg gct aat ccc 384
Gly Glu Arg Gln Leu Ile Thr Ile Ala Arg Ala Phe Leu Ala Asn Pro
115 120 125
cga ctg ctg att ctg gat gaa gcc acc tca tcg gtg gat acg cgt acc 432
Arg Leu Leu Ile Leu Asp Glu Ala Thr Ser Ser Val Asp Thr Arg Thr
130 135 140
gaa ttg ttg att cag cgc gcc atg tcc aag ctg cgc caa gac cgc acc 480
Glu Leu Leu Ile Gln Arg Ala Met Ser Lys Leu Arg Gln Asp Arg Thr
145 150 155 160
gcc ttc gtc atc gcg cac cgg ttg tcc acg att cgt gat gcc aac ctg 528
Ala Phe Val Ile Ala His Arg Leu Ser Thr Ile Arg Asp Ala Asn Leu
165 170 175
att ttg atg atg aaa gac ggc gag atc gtg gag cag ggc aat cac cgt 576
Ile Leu Met Met Lys Asp Gly Glu Ile Val Glu Gln Gly Asn His Arg
180 185 190
gag ttg atg gcc ctg gag ggc gca tat tgg gag ttg tat aac tcc caa 624
Glu Leu Met Ala Leu Glu Gly Ala Tyr Trp Glu Leu Tyr Asn Ser Gln
195 200 205
ttc aac gcc ccc gcg aaa gaa gaa tta cag gct gac gga gat cac 669
Phe Asn Ala Pro Ala Lys Glu Glu Leu Gln Ala Asp Gly Asp His
210 215 220
tgatgatttc ttcttaggct ttc 692
<210> 340
<211> 223
<212> PRT
<213> Corynebacterium glutamicum
<400> 340
Gly Pro Thr Gly Ala Gly Lys Thr Thr Leu Val Asn Leu Ile Met Arg
1 5 10 15
Phe Tyr Asp Ile Asn Ser Gly Ser Ile Thr Leu Gly Glu Thr Ala Gln
20 25 30
Asp Ala Val Asp Ile Arg Thr Met Ala Arg Glu Asp Leu Arg Ser Arg
35 40 45
Thr Gly Met Val Leu Gln Asp Thr Trp Leu Phe Ala Gly Thr Ile Arg
50 55 60
Asp Asn Ile Leu Tyr Gly Arg Pro Glu Ala Thr Glu Glu Glu Met Leu
65 70 75 80
Ala Ala Ser Lys Ala Ala Tyr Val Asp Arg Phe Val Arg Ser Leu Pro
85 90 95
Glu Gly Tyr Asp Thr Val Leu Asp Asp Glu Ala Met Asn Leu Ser Val
100 105 110
Gly Glu Arg Gln Leu Ile Thr Ile Ala Arg Ala Phe Leu Ala Asn Pro
115 120 125
Arg Leu Leu Ile Leu Asp Glu Ala Thr Ser Ser Val Asp Thr Arg Thr
130 135 140
Glu Leu Leu Ile Gln Arg Ala Met Ser Lys Leu Arg Gln Asp Arg Thr
145 150 155 160
Ala Phe Val Ile Ala His Arg Leu Ser Thr Ile Arg Asp Ala Asn Leu
165 170 175
Ile Leu Met Met Lys Asp Gly Glu Ile Val Glu Gln Gly Asn His Arg
180 185 190
Glu Leu Met Ala Leu Glu Gly Ala Tyr Trp Glu Leu Tyr Asn Ser Gln
195 200 205
Phe Asn Ala Pro Ala Lys Glu Glu Leu Gln Ala Asp Gly Asp His
210 215 220
<210> 341
<211> 1986
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1963)
<223> RXA00878
<400> 341
cgagattagg tccgcttcag ttgtggtggc tccgaatctg atgaacaatg atcattccta 60
attcatttac atctttatca aagagagcca ccacctacta atg cga ctt ctt ggt 115
Met Arg Leu Leu Gly
1 5
cga att tta aaa acc acg tct gcg ctt tgg ccc tac tat ctc gga att 163
Arg Ile Leu Lys Thr Thr Ser Ala Leu Trp Pro Tyr Tyr Leu Gly Ile
10 15 20
atc gtc gta tcc att gtg atc gcg gcg ttg tcg ctg ctg tcg ccg ttt 211
Ile Val Val Ser Ile Val Ile Ala Ala Leu Ser Leu Leu Ser Pro Phe
25 30 35
att ctc cgc gaa gca aca gat tcc att gtt tct gca gta acc gga tct 259
Ile Leu Arg Glu Ala Thr Asp Ser Ile Val Ser Ala Val Thr Gly Ser
40 45 50
aac acc gtc gat gca gtt act cgc act att att ttc tta gct tta gcc 307
Asn Thr Val Asp Ala Val Thr Arg Thr Ile Ile Phe Leu Ala Leu Ala
55 60 65
ctg ttt gtc gca agc ttc ctc aat acg gtg atg acc aac atc ggt ggc 355
Leu Phe Val Ala Ser Phe Leu Asn Thr Val Met Thr Asn Ile Gly Gly
70 75 80 85
tac atc ggt gat gtc atg gca tct cgt atg cgc cag att ctg gcc acg 403
Tyr Ile Gly Asp Val Met Ala Ser Arg Met Arg Gln Ile Leu Ala Thr
90 95 100
cgc tat tac gca aag ctg ttg gcg ctg cct cag aag tat ttt gat aat 451
Arg Tyr Tyr Ala Lys Leu Leu Ala Leu Pro Gln Lys Tyr Phe Asp Asn
105 110 115
cag gtc acc ggc acc atc atc gcc cgc ctt gat cga tca atc aac ggc 499
Gln Val Thr Gly Thr Ile Ile Ala Arg Leu Asp Arg Ser Ile Asn Gly
120 125 130
atc acg cag ttc atg cag agc ttc tcc aac aac ttc ttc ccc atg ctc 547
Ile Thr Gln Phe Met Gln Ser Phe Ser Asn Asn Phe Phe Pro Met Leu
135 140 145
atc acc atg gtg gca gtg ctg att att tcc gcg att ttc tac tgg cct 595
Ile Thr Met Val Ala Val Leu Ile Ile Ser Ala Ile Phe Tyr Trp Pro
150 155 160 165
ctg gca att ctg ctg gcc atg ttg ttc ccg att tac atg tgg ctg acg 643
Leu Ala Ile Leu Leu Ala Met Leu Phe Pro Ile Tyr Met Trp Leu Thr
170 175 180
gcg ttg aca tcg aaa cgc tgg cag aaa tat gag ggc gag aaa aac cat 691
Ala Leu Thr Ser Lys Arg Trp Gln Lys Tyr Glu Gly Glu Lys Asn His
185 190 195
gaa atc gac gtg gct aac ggc cgc ttc gct gag gtt gtc ggc cag gtc 739
Glu Ile Asp Val Ala Asn Gly Arg Phe Ala Glu Val Val Gly Gln Val
200 205 210
aag gtt gtt aaa tca ttc gtc gca gag acc cgc gag ctg gct gat ttc 787
Lys Val Val Lys Ser Phe Val Ala Glu Thr Arg Glu Leu Ala Asp Phe
215 220 225
ggt ggg cgt tac ggc aaa aca gta gcg att acc cgg ccg caa tcc ggt 835
Gly Gly Arg Tyr Gly Lys Thr Val Ala Ile Thr Arg Pro Gln Ser Gly
230 235 240 245
tgg tgg cac cgc atg gat act ctc cgt ggc gcg gca cta aat atc atc 883
Trp Trp His Arg Met Asp Thr Leu Arg Gly Ala Ala Leu Asn Ile Ile
250 255 260
ttc ctg gcc att cac ctg ctg att ttc tac cgc acc ttg cac ggc cat 931
Phe Leu Ala Ile His Leu Leu Ile Phe Tyr Arg Thr Leu His Gly His
265 270 275
ttc acc atc ggc gac atg gtc atg ctc atc cag ctt gtc acc atg gcg 979
Phe Thr Ile Gly Asp Met Val Met Leu Ile Gln Leu Val Thr Met Ala
280 285 290
cag caa ccg gtg tac atg atg agc tac atc gtc gac tcc gcg cag cgc 1027
Gln Gln Pro Val Tyr Met Met Ser Tyr Ile Val Asp Ser Ala Gln Arg
295 300 305
gcc atc gcc ggc tcc cgc gac tac ttc gag gtc atg gcg cag cag gtc 1075
Ala Ile Ala Gly Ser Arg Asp Tyr Phe Glu Val Met Ala Gln Gln Val
310 315 320 325
gag ccc acc gcc aat aag gag ctt gtc gac gcc acc ctc gcc tca gac 1123
Glu Pro Thr Ala Asn Lys Glu Leu Val Asp Ala Thr Leu Ala Ser Asp
330 335 340
act cca cgc atc agt gtg ggc acg ccc gcc gcg ctg ccc gct gga gaa 1171
Thr Pro Arg Ile Ser Val Gly Thr Pro Ala Ala Leu Pro Ala Gly Glu
345 350 355
cca gcg atg gaa ttc aaa aac gtc acc ttc gcc tac gaa gaa ggc aag 1219
Pro Ala Met Glu Phe Lys Asn Val Thr Phe Ala Tyr Glu Glu Gly Lys
360 365 370
ccg gtt att tcc gac gtg tcc att acc gcc cgc cac ggc gag cgc atc 1267
Pro Val Ile Ser Asp Val Ser Ile Thr Ala Arg His Gly Glu Arg Ile
375 380 385
gcg ttg gtc ggt gaa tcc ggc ggc ggt aaa tcc acc ctg gtc aac ctt 1315
Ala Leu Val Gly Glu Ser Gly Gly Gly Lys Ser Thr Leu Val Asn Leu
390 395 400 405
ctg tta ggt ctg tac aaa cca aac agc ggc agc ctt gca gta tgt ggc 1363
Leu Leu Gly Leu Tyr Lys Pro Asn Ser Gly Ser Leu Ala Val Cys Gly
410 415 420
gtg gat gtt aaa gat ctg act tcc gag gaa ctt cgc gca tcc gtg ggt 1411
Val Asp Val Lys Asp Leu Thr Ser Glu Glu Leu Arg Ala Ser Val Gly
425 430 435
gtg gtc ttc cag gac gcc agc ttg ttc tct gga tct att gca gaa aac 1459
Val Val Phe Gln Asp Ala Ser Leu Phe Ser Gly Ser Ile Ala Glu Asn
440 445 450
atc gcc tac ggt cgc cca ggt gcc acc cgc gaa gag atc atc gaa gtg 1507
Ile Ala Tyr Gly Arg Pro Gly Ala Thr Arg Glu Glu Ile Ile Glu Val
455 460 465
gct aag aaa gcc aac gca cat gag ttc att tcc gcc ttc cct gaa gga 1555
Ala Lys Lys Ala Asn Ala His Glu Phe Ile Ser Ala Phe Pro Glu Gly
470 475 480 485
tat gaa acc gtc gtc ggt gaa cgc gga ctc aaa ctt tct ggt ggc cag 1603
Tyr Glu Thr Val Val Gly Glu Arg Gly Leu Lys Leu Ser Gly Gly Gln
490 495 500
aag cag cgc gtc tct gtg gca cgg gcc atg ctt aaa gat gcc cca ctt 1651
Lys Gln Arg Val Ser Val Ala Arg Ala Met Leu Lys Asp Ala Pro Leu
505 510 515
ctt gtt ctc gat gaa gcc acc tct gca ctg gat acc aag tct gag cag 1699
Leu Val Leu Asp Glu Ala Thr Ser Ala Leu Asp Thr Lys Ser Glu Gln
520 525 530
gca gtc caa gcc ggt ttg gaa cag ctg atg gaa aac cgc acc acc tta 1747
Ala Val Gln Ala Gly Leu Glu Gln Leu Met Glu Asn Arg Thr Thr Leu
535 540 545
atg atc gcc cac cgc ctg tcc acc atc gca ggc gtc gat acc atc gtg 1795
Met Ile Ala His Arg Leu Ser Thr Ile Ala Gly Val Asp Thr Ile Val
550 555 560 565
acc atc caa aac gga cgg gtt gaa gag gtc gga tct cct acc gag ctc 1843
Thr Ile Gln Asn Gly Arg Val Glu Glu Val Gly Ser Pro Thr Glu Leu
570 575 580
gca gtc tca ggc ggt atc tat tcc gaa ctg ctg cgc ctg acc aac tcc 1891
Ala Val Ser Gly Gly Ile Tyr Ser Glu Leu Leu Arg Leu Thr Asn Ser
585 590 595
aca gca gaa gcc gac cgg gag cgt ctg cgc gcc ttt ggt ttc act ggc 1939
Thr Ala Glu Ala Asp Arg Glu Arg Leu Arg Ala Phe Gly Phe Thr Gly
600 605 610
gat gca cca gct gaa gaa gag gac tagccccgcg aaagaacaat ccc 1986
Asp Ala Pro Ala Glu Glu Glu Asp
615 620
<210> 342
<211> 621
<212> PRT
<213> Corynebacterium glutamicum
<400> 342
Met Arg Leu Leu Gly Arg Ile Leu Lys Thr Thr Ser Ala Leu Trp Pro
1 5 10 15
Tyr Tyr Leu Gly Ile Ile Val Val Ser Ile Val Ile Ala Ala Leu Ser
20 25 30
Leu Leu Ser Pro Phe Ile Leu Arg Glu Ala Thr Asp Ser Ile Val Ser
35 40 45
Ala Val Thr Gly Ser Asn Thr Val Asp Ala Val Thr Arg Thr Ile Ile
50 55 60
Phe Leu Ala Leu Ala Leu Phe Val Ala Ser Phe Leu Asn Thr Val Met
65 70 75 80
Thr Asn Ile Gly Gly Tyr Ile Gly Asp Val Met Ala Ser Arg Met Arg
85 90 95
Gln Ile Leu Ala Thr Arg Tyr Tyr Ala Lys Leu Leu Ala Leu Pro Gln
100 105 110
Lys Tyr Phe Asp Asn Gln Val Thr Gly Thr Ile Ile Ala Arg Leu Asp
115 120 125
Arg Ser Ile Asn Gly Ile Thr Gln Phe Met Gln Ser Phe Ser Asn Asn
130 135 140
Phe Phe Pro Met Leu Ile Thr Met Val Ala Val Leu Ile Ile Ser Ala
145 150 155 160
Ile Phe Tyr Trp Pro Leu Ala Ile Leu Leu Ala Met Leu Phe Pro Ile
165 170 175
Tyr Met Trp Leu Thr Ala Leu Thr Ser Lys Arg Trp Gln Lys Tyr Glu
180 185 190
Gly Glu Lys Asn His Glu Ile Asp Val Ala Asn Gly Arg Phe Ala Glu
195 200 205
Val Val Gly Gln Val Lys Val Val Lys Ser Phe Val Ala Glu Thr Arg
210 215 220
Glu Leu Ala Asp Phe Gly Gly Arg Tyr Gly Lys Thr Val Ala Ile Thr
225 230 235 240
Arg Pro Gln Ser Gly Trp Trp His Arg Met Asp Thr Leu Arg Gly Ala
245 250 255
Ala Leu Asn Ile Ile Phe Leu Ala Ile His Leu Leu Ile Phe Tyr Arg
260 265 270
Thr Leu His Gly His Phe Thr Ile Gly Asp Met Val Met Leu Ile Gln
275 280 285
Leu Val Thr Met Ala Gln Gln Pro Val Tyr Met Met Ser Tyr Ile Val
290 295 300
Asp Ser Ala Gln Arg Ala Ile Ala Gly Ser Arg Asp Tyr Phe Glu Val
305 310 315 320
Met Ala Gln Gln Val Glu Pro Thr Ala Asn Lys Glu Leu Val Asp Ala
325 330 335
Thr Leu Ala Ser Asp Thr Pro Arg Ile Ser Val Gly Thr Pro Ala Ala
340 345 350
Leu Pro Ala Gly Glu Pro Ala Met Glu Phe Lys Asn Val Thr Phe Ala
355 360 365
Tyr Glu Glu Gly Lys Pro Val Ile Ser Asp Val Ser Ile Thr Ala Arg
370 375 380
His Gly Glu Arg Ile Ala Leu Val Gly Glu Ser Gly Gly Gly Lys Ser
385 390 395 400
Thr Leu Val Asn Leu Leu Leu Gly Leu Tyr Lys Pro Asn Ser Gly Ser
405 410 415
Leu Ala Val Cys Gly Val Asp Val Lys Asp Leu Thr Ser Glu Glu Leu
420 425 430
Arg Ala Ser Val Gly Val Val Phe Gln Asp Ala Ser Leu Phe Ser Gly
435 440 445
Ser Ile Ala Glu Asn Ile Ala Tyr Gly Arg Pro Gly Ala Thr Arg Glu
450 455 460
Glu Ile Ile Glu Val Ala Lys Lys Ala Asn Ala His Glu Phe Ile Ser
465 470 475 480
Ala Phe Pro Glu Gly Tyr Glu Thr Val Val Gly Glu Arg Gly Leu Lys
485 490 495
Leu Ser Gly Gly Gln Lys Gln Arg Val Ser Val Ala Arg Ala Met Leu
500 505 510
Lys Asp Ala Pro Leu Leu Val Leu Asp Glu Ala Thr Ser Ala Leu Asp
515 520 525
Thr Lys Ser Glu Gln Ala Val Gln Ala Gly Leu Glu Gln Leu Met Glu
530 535 540
Asn Arg Thr Thr Leu Met Ile Ala His Arg Leu Ser Thr Ile Ala Gly
545 550 555 560
Val Asp Thr Ile Val Thr Ile Gln Asn Gly Arg Val Glu Glu Val Gly
565 570 575
Ser Pro Thr Glu Leu Ala Val Ser Gly Gly Ile Tyr Ser Glu Leu Leu
580 585 590
Arg Leu Thr Asn Ser Thr Ala Glu Ala Asp Arg Glu Arg Leu Arg Ala
595 600 605
Phe Gly Phe Thr Gly Asp Ala Pro Ala Glu Glu Glu Asp
610 615 620
<210> 343
<211> 1713
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1690)
<223> RXN01191
<400> 343
cgctgctttc acgcaactga aaccgcaccg gatcaagtta tttggggttg ttctttgtgg 60
cgtgttggtg gccgtcgcgg ggttggtagg gccctgggcg gtg ggt gga ctc gtc 115
Val Gly Gly Leu Val
1 5
gat aag ctc ctt gca acc ccg agc atg cgc gac gtt gta gtg ttc gcg 163
Asp Lys Leu Leu Ala Thr Pro Ser Met Arg Asp Val Val Val Phe Ala
10 15 20
ctg ctt atc gtg gct ggc ggc gtt gtt tcg agc ctg ggc acg tgg tgg 211
Leu Leu Ile Val Ala Gly Gly Val Val Ser Ser Leu Gly Thr Trp Trp
25 30 35
ggc agc gcg ctg atg gcg cgc gcg ttg gag ccg gcg atc gcg ggg ctg 259
Gly Ser Ala Leu Met Ala Arg Ala Leu Glu Pro Ala Ile Ala Gly Leu
40 45 50
cgc gag gat gtg ttg cgc gcg gcg gtg agt ttg gat gcg aac acg att 307
Arg Glu Asp Val Leu Arg Ala Ala Val Ser Leu Asp Ala Asn Thr Ile
55 60 65
gaa acg gcg ggg cgc ggc gac gtg att tcg cgt atc gcg gat gat tcg 355
Glu Thr Ala Gly Arg Gly Asp Val Ile Ser Arg Ile Ala Asp Asp Ser
70 75 80 85
cgg gag gtg tcc act gcg gcg agc acc gtg gtg ccg ctg atg gtg cag 403
Arg Glu Val Ser Thr Ala Ala Ser Thr Val Val Pro Leu Met Val Gln
90 95 100
gcg ggc ttt acc gtg gtg att tcc gcg ttt ggc atg gcg gcg gtt gat 451
Ala Gly Phe Thr Val Val Ile Ser Ala Phe Gly Met Ala Ala Val Asp
105 110 115
tgg cgc ctc ggc ctt gtc ggt ttg gtc gcg atc ccg ctg tat tgg acc 499
Trp Arg Leu Gly Leu Val Gly Leu Val Ala Ile Pro Leu Tyr Trp Thr
120 125 130
acg ttg cgc gtc tat tta ccc cgc tca ggt ccg ctt tat acg cgt gag 547
Thr Leu Arg Val Tyr Leu Pro Arg Ser Gly Pro Leu Tyr Thr Arg Glu
135 140 145
cgc gag gcc ttt ggg gtg cgc acg cag cgg ctt gtc ggc gca gtc gaa 595
Arg Glu Ala Phe Gly Val Arg Thr Gln Arg Leu Val Gly Ala Val Glu
150 155 160 165
ggc gcg gaa acc ttg cgc gct ttc cgc gca gaa gat aca gaa tta aag 643
Gly Ala Glu Thr Leu Arg Ala Phe Arg Ala Glu Asp Thr Glu Leu Lys
170 175 180
cgt atc gac gca gcc tcc ggc gaa gcc cgc gac att tcc att tct gtt 691
Arg Ile Asp Ala Ala Ser Gly Glu Ala Arg Asp Ile Ser Ile Ser Val
185 190 195
ttc agg ttc ctc aca tgg gca ttt tcc cgc aac aac cgc gcg gaa tgc 739
Phe Arg Phe Leu Thr Trp Ala Phe Ser Arg Asn Asn Arg Ala Glu Cys
200 205 210
atc acc ctc gtg ctc atc ttg ggc acc ggc ttt tac ctg gtc aac atc 787
Ile Thr Leu Val Leu Ile Leu Gly Thr Gly Phe Tyr Leu Val Asn Ile
215 220 225
gat ctg gtc acc gtc ggc gca gtc tca acc gcc gca ctg atc ttc cac 835
Asp Leu Val Thr Val Gly Ala Val Ser Thr Ala Ala Leu Ile Phe His
230 235 240 245
cga ctc ttc ggt cca atc ggc acg ctc gtg ggc atg ttc tcc gac atc 883
Arg Leu Phe Gly Pro Ile Gly Thr Leu Val Gly Met Phe Ser Asp Ile
250 255 260
caa tcc gcc agc gca tcg ctg atc cgc atg gtg ggc gtt att aac gcg 931
Gln Ser Ala Ser Ala Ser Leu Ile Arg Met Val Gly Val Ile Asn Ala
265 270 275
gca tcg aac cag gtc agc ggc acc tcg ccg gcg tct gcc agc acc gct 979
Ala Ser Asn Gln Val Ser Gly Thr Ser Pro Ala Ser Ala Ser Thr Ala
280 285 290
tta acg ctt ttc gac gtc tcc cac cac tat cac act gca ccc gtc atc 1027
Leu Thr Leu Phe Asp Val Ser His His Tyr His Thr Ala Pro Val Ile
295 300 305
aag aat gca tcc gtg cag ctg gaa cca ggg gaa cac atc gcc att gtg 1075
Lys Asn Ala Ser Val Gln Leu Glu Pro Gly Glu His Ile Ala Ile Val
310 315 320 325
ggt gcg acc ggc gct ggt aaa agc acg ctc gcc ctc att gcg gca ggc 1123
Gly Ala Thr Gly Ala Gly Lys Ser Thr Leu Ala Leu Ile Ala Ala Gly
330 335 340
ctg ctc agc cca act tcc ggg cag gtg gct ctc ggc gga tcg agt ttt 1171
Leu Leu Ser Pro Thr Ser Gly Gln Val Ala Leu Gly Gly Ser Ser Phe
345 350 355
tct aac gtc gaa ccg gaa gca ttg cgc cag aag atc gcg atg gtc agc 1219
Ser Asn Val Glu Pro Glu Ala Leu Arg Gln Lys Ile Ala Met Val Ser
360 365 370
caa gaa atc cac tgc ttc cga gga tct gtt tta gat aat ctt cgt atc 1267
Gln Glu Ile His Cys Phe Arg Gly Ser Val Leu Asp Asn Leu Arg Ile
375 380 385
gca cgc ccc gaa gcc acc gat gcg gac atc cac gcc gtt ctc gcc gat 1315
Ala Arg Pro Glu Ala Thr Asp Ala Asp Ile His Ala Val Leu Ala Asp
390 395 400 405
att ggt gat tcc tgg ttg gag cgc tta ccg caa ggc ata gac acc atc 1363
Ile Gly Asp Ser Trp Leu Glu Arg Leu Pro Gln Gly Ile Asp Thr Ile
410 415 420
gtg ggt gat ggc gct ttc cgt tta acc tct gtg gaa aac cag atc atg 1411
Val Gly Asp Gly Ala Phe Arg Leu Thr Ser Val Glu Asn Gln Ile Met
425 430 435
gcg ctt gct cgc gta cat ttg gcc gac cta gca atc gtc atc ctt gat 1459
Ala Leu Ala Arg Val His Leu Ala Asp Leu Ala Ile Val Ile Leu Asp
440 445 450
gaa gca acg gct gaa tca ggc tct gat cat gca aaa cag ctt gaa gat 1507
Glu Ala Thr Ala Glu Ser Gly Ser Asp His Ala Lys Gln Leu Glu Asp
455 460 465
gca gcc ctt aaa gtc act gaa aac aga tca gcc atc atc gtg gct cac 1555
Ala Ala Leu Lys Val Thr Glu Asn Arg Ser Ala Ile Ile Val Ala His
470 475 480 485
cgc ctc aac caa gcg aaa acc gcc gat cgc atc atc gtc atg gac tcc 1603
Arg Leu Asn Gln Ala Lys Thr Ala Asp Arg Ile Ile Val Met Asp Ser
490 495 500
gga gaa atc ata gaa tct gga acc cat gaa gag ctt cga gcg atc ggc 1651
Gly Glu Ile Ile Glu Ser Gly Thr His Glu Glu Leu Arg Ala Ile Gly
505 510 515
ggc cga tat gaa caa ctg tgg act gcg tgg tct gcg cgc taattagcca 1700
Gly Arg Tyr Glu Gln Leu Trp Thr Ala Trp Ser Ala Arg
520 525 530
cccaagacca cgc 1713
<210> 344
<211> 530
<212> PRT
<213> Corynebacterium glutamicum
<400> 344
Val Gly Gly Leu Val Asp Lys Leu Leu Ala Thr Pro Ser Met Arg Asp
1 5 10 15
Val Val Val Phe Ala Leu Leu Ile Val Ala Gly Gly Val Val Ser Ser
20 25 30
Leu Gly Thr Trp Trp Gly Ser Ala Leu Met Ala Arg Ala Leu Glu Pro
35 40 45
Ala Ile Ala Gly Leu Arg Glu Asp Val Leu Arg Ala Ala Val Ser Leu
50 55 60
Asp Ala Asn Thr Ile Glu Thr Ala Gly Arg Gly Asp Val Ile Ser Arg
65 70 75 80
Ile Ala Asp Asp Ser Arg Glu Val Ser Thr Ala Ala Ser Thr Val Val
85 90 95
Pro Leu Met Val Gln Ala Gly Phe Thr Val Val Ile Ser Ala Phe Gly
100 105 110
Met Ala Ala Val Asp Trp Arg Leu Gly Leu Val Gly Leu Val Ala Ile
115 120 125
Pro Leu Tyr Trp Thr Thr Leu Arg Val Tyr Leu Pro Arg Ser Gly Pro
130 135 140
Leu Tyr Thr Arg Glu Arg Glu Ala Phe Gly Val Arg Thr Gln Arg Leu
145 150 155 160
Val Gly Ala Val Glu Gly Ala Glu Thr Leu Arg Ala Phe Arg Ala Glu
165 170 175
Asp Thr Glu Leu Lys Arg Ile Asp Ala Ala Ser Gly Glu Ala Arg Asp
180 185 190
Ile Ser Ile Ser Val Phe Arg Phe Leu Thr Trp Ala Phe Ser Arg Asn
195 200 205
Asn Arg Ala Glu Cys Ile Thr Leu Val Leu Ile Leu Gly Thr Gly Phe
210 215 220
Tyr Leu Val Asn Ile Asp Leu Val Thr Val Gly Ala Val Ser Thr Ala
225 230 235 240
Ala Leu Ile Phe His Arg Leu Phe Gly Pro Ile Gly Thr Leu Val Gly
245 250 255
Met Phe Ser Asp Ile Gln Ser Ala Ser Ala Ser Leu Ile Arg Met Val
260 265 270
Gly Val Ile Asn Ala Ala Ser Asn Gln Val Ser Gly Thr Ser Pro Ala
275 280 285
Ser Ala Ser Thr Ala Leu Thr Leu Phe Asp Val Ser His His Tyr His
290 295 300
Thr Ala Pro Val Ile Lys Asn Ala Ser Val Gln Leu Glu Pro Gly Glu
305 310 315 320
His Ile Ala Ile Val Gly Ala Thr Gly Ala Gly Lys Ser Thr Leu Ala
325 330 335
Leu Ile Ala Ala Gly Leu Leu Ser Pro Thr Ser Gly Gln Val Ala Leu
340 345 350
Gly Gly Ser Ser Phe Ser Asn Val Glu Pro Glu Ala Leu Arg Gln Lys
355 360 365
Ile Ala Met Val Ser Gln Glu Ile His Cys Phe Arg Gly Ser Val Leu
370 375 380
Asp Asn Leu Arg Ile Ala Arg Pro Glu Ala Thr Asp Ala Asp Ile His
385 390 395 400
Ala Val Leu Ala Asp Ile Gly Asp Ser Trp Leu Glu Arg Leu Pro Gln
405 410 415
Gly Ile Asp Thr Ile Val Gly Asp Gly Ala Phe Arg Leu Thr Ser Val
420 425 430
Glu Asn Gln Ile Met Ala Leu Ala Arg Val His Leu Ala Asp Leu Ala
435 440 445
Ile Val Ile Leu Asp Glu Ala Thr Ala Glu Ser Gly Ser Asp His Ala
450 455 460
Lys Gln Leu Glu Asp Ala Ala Leu Lys Val Thr Glu Asn Arg Ser Ala
465 470 475 480
Ile Ile Val Ala His Arg Leu Asn Gln Ala Lys Thr Ala Asp Arg Ile
485 490 495
Ile Val Met Asp Ser Gly Glu Ile Ile Glu Ser Gly Thr His Glu Glu
500 505 510
Leu Arg Ala Ile Gly Gly Arg Tyr Glu Gln Leu Trp Thr Ala Trp Ser
515 520 525
Ala Arg
530
<210> 345
<211> 1430
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(1407)
<223> FRXA01191
<400> 345
gtg agt ttg gat gcg aac acg att gaa acg gcg ggg cgc ggc gac gtg 48
Val Ser Leu Asp Ala Asn Thr Ile Glu Thr Ala Gly Arg Gly Asp Val
1 5 10 15
att tcg cgt atc gcg gat gat tcg cgg gag gtg tcc act gcg gcg agc 96
Ile Ser Arg Ile Ala Asp Asp Ser Arg Glu Val Ser Thr Ala Ala Ser
20 25 30
acc gtg gtg ccg ctg atg gtg cag gcg ggc ttt acc gtg gtg att tcc 144
Thr Val Val Pro Leu Met Val Gln Ala Gly Phe Thr Val Val Ile Ser
35 40 45
gcg ttt ggc atg gcg gcg gtt gat tgg cgc ctc ggc ctt gtc ggt ttg 192
Ala Phe Gly Met Ala Ala Val Asp Trp Arg Leu Gly Leu Val Gly Leu
50 55 60
gtc gcg atc ccg ctg tat tgg acc acg ttg cgc gtc tat tta ccc cgc 240
Val Ala Ile Pro Leu Tyr Trp Thr Thr Leu Arg Val Tyr Leu Pro Arg
65 70 75 80
tca ggt ccg ctt tat acg cgt gag cgc gag gcc ttt ggg gtg cgc acg 288
Ser Gly Pro Leu Tyr Thr Arg Glu Arg Glu Ala Phe Gly Val Arg Thr
85 90 95
cag cgg ctt gtc ggc gca gtc gaa ggc gcg gaa acc ttg cgc gct ttc 336
Gln Arg Leu Val Gly Ala Val Glu Gly Ala Glu Thr Leu Arg Ala Phe
100 105 110
cgc gca gaa gat aca gaa tta aag cgt atc gac gca gcc tcc ggc gaa 384
Arg Ala Glu Asp Thr Glu Leu Lys Arg Ile Asp Ala Ala Ser Gly Glu
115 120 125
gcc cgc gac att tcc att tct gtt ttc agg ttc ctc aca tgg gca ttt 432
Ala Arg Asp Ile Ser Ile Ser Val Phe Arg Phe Leu Thr Trp Ala Phe
130 135 140
tcc cgc aac aac cgc gcg gaa tgc atc acc ctc gtg ctc atc ttg ggc 480
Ser Arg Asn Asn Arg Ala Glu Cys Ile Thr Leu Val Leu Ile Leu Gly
145 150 155 160
acc ggc ttt tac ctg gtc aac atc gat ctg gtc acc gtc ggc gca gtc 528
Thr Gly Phe Tyr Leu Val Asn Ile Asp Leu Val Thr Val Gly Ala Val
165 170 175
tca acc gcc gca ctg atc ttc cac cga ctc ttc ggt cca atc ggc acg 576
Ser Thr Ala Ala Leu Ile Phe His Arg Leu Phe Gly Pro Ile Gly Thr
180 185 190
ctc gtg ggc atg ttc tcc gac atc caa tcc gcc agc gca tcg ctg atc 624
Leu Val Gly Met Phe Ser Asp Ile Gln Ser Ala Ser Ala Ser Leu Ile
195 200 205
cgc atg gtg ggc gtt att aac gcg gca tcg aac cag gtc agc ggc acc 672
Arg Met Val Gly Val Ile Asn Ala Ala Ser Asn Gln Val Ser Gly Thr
210 215 220
tcg ccg gcg tct gcc agc acc gct tta acg ctt ttc gac gtc tcc cac 720
Ser Pro Ala Ser Ala Ser Thr Ala Leu Thr Leu Phe Asp Val Ser His
225 230 235 240
cac tat cac act gca ccc gtc atc aag aat gca tcc gtg cag ctg gaa 768
His Tyr His Thr Ala Pro Val Ile Lys Asn Ala Ser Val Gln Leu Glu
245 250 255
cca ggg gaa cac atc gcc att gtg ggt gcg acc ggc gct ggt aaa agc 816
Pro Gly Glu His Ile Ala Ile Val Gly Ala Thr Gly Ala Gly Lys Ser
260 265 270
acg ctc gcc ctc att gcg gca ggc ctg ctc agc cca act tcc ggg cag 864
Thr Leu Ala Leu Ile Ala Ala Gly Leu Leu Ser Pro Thr Ser Gly Gln
275 280 285
gtg gct ctc ggc gga tcg agt ttt tct aac gtc gaa ccg gaa gca ttg 912
Val Ala Leu Gly Gly Ser Ser Phe Ser Asn Val Glu Pro Glu Ala Leu
290 295 300
cgc cag aag atc gcg atg gtc agc caa gaa atc cac tgc ttc cga gga 960
Arg Gln Lys Ile Ala Met Val Ser Gln Glu Ile His Cys Phe Arg Gly
305 310 315 320
tct gtt tta gat aat ctt cgt atc gca cgc ccc gaa gcc acc gat gcg 1008
Ser Val Leu Asp Asn Leu Arg Ile Ala Arg Pro Glu Ala Thr Asp Ala
325 330 335
gac atc cac gcc gtt ctc gcc gat att ggt gat tcc tgg ttg gag cgc 1056
Asp Ile His Ala Val Leu Ala Asp Ile Gly Asp Ser Trp Leu Glu Arg
340 345 350
tta ccg caa ggc ata gac acc atc gtg ggt gat ggc gct ttc cgt tta 1104
Leu Pro Gln Gly Ile Asp Thr Ile Val Gly Asp Gly Ala Phe Arg Leu
355 360 365
acc tct gtg gaa aac cag atc atg gcg ctt gct cgc gta cat ttg gcc 1152
Thr Ser Val Glu Asn Gln Ile Met Ala Leu Ala Arg Val His Leu Ala
370 375 380
gac cta gca atc gtc atc ctt gat gaa gca acg gct gaa tca ggc tct 1200
Asp Leu Ala Ile Val Ile Leu Asp Glu Ala Thr Ala Glu Ser Gly Ser
385 390 395 400
gat cat gca aaa cag ctt gaa gat gca gcc ctt aaa gtc act gaa aac 1248
Asp His Ala Lys Gln Leu Glu Asp Ala Ala Leu Lys Val Thr Glu Asn
405 410 415
aga tca gcc atc atc gtg gct cac cgc ctc aac caa gcg aaa acc gcc 1296
Arg Ser Ala Ile Ile Val Ala His Arg Leu Asn Gln Ala Lys Thr Ala
420 425 430
gat cgc atc atc gtc atg gac tcc gga gaa atc ata gaa tct gga acc 1344
Asp Arg Ile Ile Val Met Asp Ser Gly Glu Ile Ile Glu Ser Gly Thr
435 440 445
cat gaa gag ctt cga gcg atc ggc ggt cga tat gaa caa ctg tgg act 1392
His Glu Glu Leu Arg Ala Ile Gly Gly Arg Tyr Glu Gln Leu Trp Thr
450 455 460
gcg tgg tct gcg cgc taattagcca cccaagacca cgc 1430
Ala Trp Ser Ala Arg
465
<210> 346
<211> 469
<212> PRT
<213> Corynebacterium glutamicum
<400> 346
Val Ser Leu Asp Ala Asn Thr Ile Glu Thr Ala Gly Arg Gly Asp Val
1 5 10 15
Ile Ser Arg Ile Ala Asp Asp Ser Arg Glu Val Ser Thr Ala Ala Ser
20 25 30
Thr Val Val Pro Leu Met Val Gln Ala Gly Phe Thr Val Val Ile Ser
35 40 45
Ala Phe Gly Met Ala Ala Val Asp Trp Arg Leu Gly Leu Val Gly Leu
50 55 60
Val Ala Ile Pro Leu Tyr Trp Thr Thr Leu Arg Val Tyr Leu Pro Arg
65 70 75 80
Ser Gly Pro Leu Tyr Thr Arg Glu Arg Glu Ala Phe Gly Val Arg Thr
85 90 95
Gln Arg Leu Val Gly Ala Val Glu Gly Ala Glu Thr Leu Arg Ala Phe
100 105 110
Arg Ala Glu Asp Thr Glu Leu Lys Arg Ile Asp Ala Ala Ser Gly Glu
115 120 125
Ala Arg Asp Ile Ser Ile Ser Val Phe Arg Phe Leu Thr Trp Ala Phe
130 135 140
Ser Arg Asn Asn Arg Ala Glu Cys Ile Thr Leu Val Leu Ile Leu Gly
145 150 155 160
Thr Gly Phe Tyr Leu Val Asn Ile Asp Leu Val Thr Val Gly Ala Val
165 170 175
Ser Thr Ala Ala Leu Ile Phe His Arg Leu Phe Gly Pro Ile Gly Thr
180 185 190
Leu Val Gly Met Phe Ser Asp Ile Gln Ser Ala Ser Ala Ser Leu Ile
195 200 205
Arg Met Val Gly Val Ile Asn Ala Ala Ser Asn Gln Val Ser Gly Thr
210 215 220
Ser Pro Ala Ser Ala Ser Thr Ala Leu Thr Leu Phe Asp Val Ser His
225 230 235 240
His Tyr His Thr Ala Pro Val Ile Lys Asn Ala Ser Val Gln Leu Glu
245 250 255
Pro Gly Glu His Ile Ala Ile Val Gly Ala Thr Gly Ala Gly Lys Ser
260 265 270
Thr Leu Ala Leu Ile Ala Ala Gly Leu Leu Ser Pro Thr Ser Gly Gln
275 280 285
Val Ala Leu Gly Gly Ser Ser Phe Ser Asn Val Glu Pro Glu Ala Leu
290 295 300
Arg Gln Lys Ile Ala Met Val Ser Gln Glu Ile His Cys Phe Arg Gly
305 310 315 320
Ser Val Leu Asp Asn Leu Arg Ile Ala Arg Pro Glu Ala Thr Asp Ala
325 330 335
Asp Ile His Ala Val Leu Ala Asp Ile Gly Asp Ser Trp Leu Glu Arg
340 345 350
Leu Pro Gln Gly Ile Asp Thr Ile Val Gly Asp Gly Ala Phe Arg Leu
355 360 365
Thr Ser Val Glu Asn Gln Ile Met Ala Leu Ala Arg Val His Leu Ala
370 375 380
Asp Leu Ala Ile Val Ile Leu Asp Glu Ala Thr Ala Glu Ser Gly Ser
385 390 395 400
Asp His Ala Lys Gln Leu Glu Asp Ala Ala Leu Lys Val Thr Glu Asn
405 410 415
Arg Ser Ala Ile Ile Val Ala His Arg Leu Asn Gln Ala Lys Thr Ala
420 425 430
Asp Arg Ile Ile Val Met Asp Ser Gly Glu Ile Ile Glu Ser Gly Thr
435 440 445
His Glu Glu Leu Arg Ala Ile Gly Gly Arg Tyr Glu Gln Leu Trp Thr
450 455 460
Ala Trp Ser Ala Arg
465
<210> 347
<211> 1047
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1024)
<223> RXN01212
<400> 347
tttagaagcc acatgacata tgtcatgaaa attatgtgca aagtgcagta atactcctga 60
catatggctc taccagcgcc aatgcgaagt aggaagaatt atg cct atg aca acg 115
Met Pro Met Thr Thr
1 5
aca cca gca atc gac gta aca gac ctc gtg aga acc tac ggc gac tac 163
Thr Pro Ala Ile Asp Val Thr Asp Leu Val Arg Thr Tyr Gly Asp Tyr
10 15 20
acc gca gtc aag ggc ctg aat ttc cat gta cag cgc ggt gaa gta ttt 211
Thr Ala Val Lys Gly Leu Asn Phe His Val Gln Arg Gly Glu Val Phe
25 30 35
ggt ctg ctc ggc acc aac ggg gcc ggc aaa acc tcc acc ttg gaa gtc 259
Gly Leu Leu Gly Thr Asn Gly Ala Gly Lys Thr Ser Thr Leu Glu Val
40 45 50
atc gaa gga ctt tcc gca ccc agc tcc ggc acc gtg cgc atc tcc ggg 307
Ile Glu Gly Leu Ser Ala Pro Ser Ser Gly Thr Val Arg Ile Ser Gly
55 60 65
ctt gac ccc gtt gcc gac cgc gcg atc ctg cgc ccc gag ctc ggc atc 355
Leu Asp Pro Val Ala Asp Arg Ala Ile Leu Arg Pro Glu Leu Gly Ile
70 75 80 85
atg ctg caa tca ggc ggc ctg cca tca cag ctc acc gtc gcc gaa acc 403
Met Leu Gln Ser Gly Gly Leu Pro Ser Gln Leu Thr Val Ala Glu Thr
90 95 100
atg gac atg tgg cac ggc acc tgc acg tat ccg cgc gcc att aaa gat 451
Met Asp Met Trp His Gly Thr Cys Thr Tyr Pro Arg Ala Ile Lys Asp
105 110 115
gtg ctt gcc gac gtc gac ctc cta cac cgc gaa aac gtc aag gtc ggc 499
Val Leu Ala Asp Val Asp Leu Leu His Arg Glu Asn Val Lys Val Gly
120 125 130
gcg ctt tcc gga ggc gaa caa cga cgc ctt gat ttg gcc tgc gca ctg 547
Ala Leu Ser Gly Gly Glu Gln Arg Arg Leu Asp Leu Ala Cys Ala Leu
135 140 145
ctt ggc gac ccc tca att ttg ttc ctc gac gaa ccc acc acc ggc ctc 595
Leu Gly Asp Pro Ser Ile Leu Phe Leu Asp Glu Pro Thr Thr Gly Leu
150 155 160 165
gac cca gaa tct agg cgc cac acc tgg caa ctc ctg ctg gac ctg aaa 643
Asp Pro Glu Ser Arg Arg His Thr Trp Gln Leu Leu Leu Asp Leu Lys
170 175 180
cag cgc ggc gtc acc atg atg ctg acc acc cac tac ctg gag gaa gcc 691
Gln Arg Gly Val Thr Met Met Leu Thr Thr His Tyr Leu Glu Glu Ala
185 190 195
gaa ttc ctc tgc gac cgg att gcc atc atg aac gcc ggt gag atc gca 739
Glu Phe Leu Cys Asp Arg Ile Ala Ile Met Asn Ala Gly Glu Ile Ala
200 205 210
gtg gaa ggc acc ttg gat gaa ctg gtg gcc cgc gag aag tcg atc atc 787
Val Glu Gly Thr Leu Asp Glu Leu Val Ala Arg Glu Lys Ser Ile Ile
215 220 225
agt ttc gtg ctg cgt ggc ggg cag gtg gag ttg ccg gtc ttg agt ggg 835
Ser Phe Val Leu Arg Gly Gly Gln Val Glu Leu Pro Val Leu Ser Gly
230 235 240 245
gct gaa atc atc cgc gac aac aac cac gtc cgc atc gcc acc acc acc 883
Ala Glu Ile Ile Arg Asp Asn Asn His Val Arg Ile Ala Thr Thr Thr
250 255 260
ctg cag cag cac acc tta gaa ata ctt acc tgg gct gca gag acc ggg 931
Leu Gln Gln His Thr Leu Glu Ile Leu Thr Trp Ala Ala Glu Thr Gly
265 270 275
atc gcg ctg gaa ggc ttc gct gca aaa ccc gcc acc ttg gaa tcc gta 979
Ile Ala Leu Glu Gly Phe Ala Ala Lys Pro Ala Thr Leu Glu Ser Val
280 285 290
ttc atg gac atc gcc tca ctc gag aac acc tcg ctg caa acc gcc 1024
Phe Met Asp Ile Ala Ser Leu Glu Asn Thr Ser Leu Gln Thr Ala
295 300 305
tagaatcttt aaggagacca caa 1047
<210> 348
<211> 308
<212> PRT
<213> Corynebacterium glutamicum
<400> 348
Met Pro Met Thr Thr Thr Pro Ala Ile Asp Val Thr Asp Leu Val Arg
1 5 10 15
Thr Tyr Gly Asp Tyr Thr Ala Val Lys Gly Leu Asn Phe His Val Gln
20 25 30
Arg Gly Glu Val Phe Gly Leu Leu Gly Thr Asn Gly Ala Gly Lys Thr
35 40 45
Ser Thr Leu Glu Val Ile Glu Gly Leu Ser Ala Pro Ser Ser Gly Thr
50 55 60
Val Arg Ile Ser Gly Leu Asp Pro Val Ala Asp Arg Ala Ile Leu Arg
65 70 75 80
Pro Glu Leu Gly Ile Met Leu Gln Ser Gly Gly Leu Pro Ser Gln Leu
85 90 95
Thr Val Ala Glu Thr Met Asp Met Trp His Gly Thr Cys Thr Tyr Pro
100 105 110
Arg Ala Ile Lys Asp Val Leu Ala Asp Val Asp Leu Leu His Arg Glu
115 120 125
Asn Val Lys Val Gly Ala Leu Ser Gly Gly Glu Gln Arg Arg Leu Asp
130 135 140
Leu Ala Cys Ala Leu Leu Gly Asp Pro Ser Ile Leu Phe Leu Asp Glu
145 150 155 160
Pro Thr Thr Gly Leu Asp Pro Glu Ser Arg Arg His Thr Trp Gln Leu
165 170 175
Leu Leu Asp Leu Lys Gln Arg Gly Val Thr Met Met Leu Thr Thr His
180 185 190
Tyr Leu Glu Glu Ala Glu Phe Leu Cys Asp Arg Ile Ala Ile Met Asn
195 200 205
Ala Gly Glu Ile Ala Val Glu Gly Thr Leu Asp Glu Leu Val Ala Arg
210 215 220
Glu Lys Ser Ile Ile Ser Phe Val Leu Arg Gly Gly Gln Val Glu Leu
225 230 235 240
Pro Val Leu Ser Gly Ala Glu Ile Ile Arg Asp Asn Asn His Val Arg
245 250 255
Ile Ala Thr Thr Thr Leu Gln Gln His Thr Leu Glu Ile Leu Thr Trp
260 265 270
Ala Ala Glu Thr Gly Ile Ala Leu Glu Gly Phe Ala Ala Lys Pro Ala
275 280 285
Thr Leu Glu Ser Val Phe Met Asp Ile Ala Ser Leu Glu Asn Thr Ser
290 295 300
Leu Gln Thr Ala
305
<210> 349
<211> 813
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(813)
<223> FRXA01212
<400> 349
ggc ctg aat ttc cat gta cag cgc ggt gaa gta ttt ggt ctg ctc ggc 48
Gly Leu Asn Phe His Val Gln Arg Gly Glu Val Phe Gly Leu Leu Gly
1 5 10 15
acc aac ggg gcc ggc aaa acc tcc acc ttg gaa gtc atc gaa gga ctt 96
Thr Asn Gly Ala Gly Lys Thr Ser Thr Leu Glu Val Ile Glu Gly Leu
20 25 30
tcc gca ccc agc tcc ggc acc gtg cgc atc tcc ggg ctt gac ccc gtt 144
Ser Ala Pro Ser Ser Gly Thr Val Arg Ile Ser Gly Leu Asp Pro Val
35 40 45
gcc gac cgc gcg atc ctg cgc ccc gag ctc ggc atc atg ctg caa tca 192
Ala Asp Arg Ala Ile Leu Arg Pro Glu Leu Gly Ile Met Leu Gln Ser
50 55 60
ggc ggc ctg cca tca cag ctc acc gtc gcc gaa acc atg gac atg tgg 240
Gly Gly Leu Pro Ser Gln Leu Thr Val Ala Glu Thr Met Asp Met Trp
65 70 75 80
cac ggc acc tgc acg tat ccg cgc gcc att aaa gat gtg ctt gcc gac 288
His Gly Thr Cys Thr Tyr Pro Arg Ala Ile Lys Asp Val Leu Ala Asp
85 90 95
gtc gac ctc cta cac cgc gaa aac gtc aag gtc ggc gcg ctt tcc gga 336
Val Asp Leu Leu His Arg Glu Asn Val Lys Val Gly Ala Leu Ser Gly
100 105 110
ggc gaa caa cga cgc ctt gat ttg gcc tgc gca ctg ctt ggc gac ccc 384
Gly Glu Gln Arg Arg Leu Asp Leu Ala Cys Ala Leu Leu Gly Asp Pro
115 120 125
tca att ttg ttc ctc gac gaa ccc acc acc ggc ctc gac cca gaa tct 432
Ser Ile Leu Phe Leu Asp Glu Pro Thr Thr Gly Leu Asp Pro Glu Ser
130 135 140
agg cgc cac acc tgg caa ctc ctg ctg gac ctg aaa cag cgc ggc gtc 480
Arg Arg His Thr Trp Gln Leu Leu Leu Asp Leu Lys Gln Arg Gly Val
145 150 155 160
acc atg atg ctg acc acc cac tac ctg gag gaa gcc gaa ttc ctc tgc 528
Thr Met Met Leu Thr Thr His Tyr Leu Glu Glu Ala Glu Phe Leu Cys
165 170 175
gac cgg att gcc atc atg aac gcc ggt gag atc gca gtg gaa ggc acc 576
Asp Arg Ile Ala Ile Met Asn Ala Gly Glu Ile Ala Val Glu Gly Thr
180 185 190
ttg gat gaa ctg gtg gcc cgc gag aag tcg atc atc agt ttc gtg ctg 624
Leu Asp Glu Leu Val Ala Arg Glu Lys Ser Ile Ile Ser Phe Val Leu
195 200 205
cgt ggc ggg cag gtg gag ttg ccg gtc ttg agt ggg gct gaa atc atc 672
Arg Gly Gly Gln Val Glu Leu Pro Val Leu Ser Gly Ala Glu Ile Ile
210 215 220
cgc gac aac aac cac gtc cgc atc gcc acc acc acc ctg cag cag cac 720
Arg Asp Asn Asn His Val Arg Ile Ala Thr Thr Thr Leu Gln Gln His
225 230 235 240
acc tta gaa ata ctt acc tgg gct gca gag acc ggg atc gcg ctg gaa 768
Thr Leu Glu Ile Leu Thr Trp Ala Ala Glu Thr Gly Ile Ala Leu Glu
245 250 255
ggc ttc gct gca aaa ccc gcc acc ttg gaa tcc gta ttc atg gac 813
Gly Phe Ala Ala Lys Pro Ala Thr Leu Glu Ser Val Phe Met Asp
260 265 270
<210> 350
<211> 271
<212> PRT
<213> Corynebacterium glutamicum
<400> 350
Gly Leu Asn Phe His Val Gln Arg Gly Glu Val Phe Gly Leu Leu Gly
1 5 10 15
Thr Asn Gly Ala Gly Lys Thr Ser Thr Leu Glu Val Ile Glu Gly Leu
20 25 30
Ser Ala Pro Ser Ser Gly Thr Val Arg Ile Ser Gly Leu Asp Pro Val
35 40 45
Ala Asp Arg Ala Ile Leu Arg Pro Glu Leu Gly Ile Met Leu Gln Ser
50 55 60
Gly Gly Leu Pro Ser Gln Leu Thr Val Ala Glu Thr Met Asp Met Trp
65 70 75 80
His Gly Thr Cys Thr Tyr Pro Arg Ala Ile Lys Asp Val Leu Ala Asp
85 90 95
Val Asp Leu Leu His Arg Glu Asn Val Lys Val Gly Ala Leu Ser Gly
100 105 110
Gly Glu Gln Arg Arg Leu Asp Leu Ala Cys Ala Leu Leu Gly Asp Pro
115 120 125
Ser Ile Leu Phe Leu Asp Glu Pro Thr Thr Gly Leu Asp Pro Glu Ser
130 135 140
Arg Arg His Thr Trp Gln Leu Leu Leu Asp Leu Lys Gln Arg Gly Val
145 150 155 160
Thr Met Met Leu Thr Thr His Tyr Leu Glu Glu Ala Glu Phe Leu Cys
165 170 175
Asp Arg Ile Ala Ile Met Asn Ala Gly Glu Ile Ala Val Glu Gly Thr
180 185 190
Leu Asp Glu Leu Val Ala Arg Glu Lys Ser Ile Ile Ser Phe Val Leu
195 200 205
Arg Gly Gly Gln Val Glu Leu Pro Val Leu Ser Gly Ala Glu Ile Ile
210 215 220
Arg Asp Asn Asn His Val Arg Ile Ala Thr Thr Thr Leu Gln Gln His
225 230 235 240
Thr Leu Glu Ile Leu Thr Trp Ala Ala Glu Thr Gly Ile Ala Leu Glu
245 250 255
Gly Phe Ala Ala Lys Pro Ala Thr Leu Glu Ser Val Phe Met Asp
260 265 270
<210> 351
<211> 999
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(976)
<223> RXA02749
<400> 351
caacctagac ttcggtaaga agtaactttg ctttagttgg tcggcgcatc actttcccta 60
agcgatgcgc cgattacttg tttttgctac aaatttaact atg tca ccc atc cta 115
Met Ser Pro Ile Leu
1 5
aaa gtg cgg gac ctc gtc aaa cgc tat ggc gac acc gtt gcg gtt gac 163
Lys Val Arg Asp Leu Val Lys Arg Tyr Gly Asp Thr Val Ala Val Asp
10 15 20
ggt tta aat ttt gat gtt tca caa ggg gaa att ttt gcc ttt cta ggg 211
Gly Leu Asn Phe Asp Val Ser Gln Gly Glu Ile Phe Ala Phe Leu Gly
25 30 35
gag aac ggc gca gga aaa aca acc acg att tca tgc ctg att ggc att 259
Glu Asn Gly Ala Gly Lys Thr Thr Thr Ile Ser Cys Leu Ile Gly Ile
40 45 50
gat caa gcc acc tct ggg gag atc gaa ctg cag ggt ggc caa gta gat 307
Asp Gln Ala Thr Ser Gly Glu Ile Glu Leu Gln Gly Gly Gln Val Asp
55 60 65
tct gaa aaa ctt gga gtg gtg ttt caa caa tcc gtc tta gac cct ttg 355
Ser Glu Lys Leu Gly Val Val Phe Gln Gln Ser Val Leu Asp Pro Leu
70 75 80 85
ctg agt gcc aaa gaa aac ttg gaa aca cgc gga cag ctg tac cca ggg 403
Leu Ser Ala Lys Glu Asn Leu Glu Thr Arg Gly Gln Leu Tyr Pro Gly
90 95 100
gtg ggg aag cag cgg gtt gca cag ctc att gag caa atc ggg atg gaa 451
Val Gly Lys Gln Arg Val Ala Gln Leu Ile Glu Gln Ile Gly Met Glu
105 110 115
ggg ttt gcg gac cgc cga tac gga gtg ttg tcg ggc ggt gaa aaa cgt 499
Gly Phe Ala Asp Arg Arg Tyr Gly Val Leu Ser Gly Gly Glu Lys Arg
120 125 130
cgc acc gac atc gca cga gct tta ctg cac agc cca gac att ctt ttt 547
Arg Thr Asp Ile Ala Arg Ala Leu Leu His Ser Pro Asp Ile Leu Phe
135 140 145
ctt gat gaa ccc aca gca ggc ctc gac ccc aga tca cga cgc caa gtt 595
Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro Arg Ser Arg Arg Gln Val
150 155 160 165
tgg gac acc atc aat tcc ctg cgt aac gat gtg ggc ctc act gtc ttt 643
Trp Asp Thr Ile Asn Ser Leu Arg Asn Asp Val Gly Leu Thr Val Phe
170 175 180
ttg acc act cac tac atg gaa gaa aca gaa ctg gct gat tca gtt cta 691
Leu Thr Thr His Tyr Met Glu Glu Thr Glu Leu Ala Asp Ser Val Leu
185 190 195
atc att gac cgt ggc aaa gag gtc gca tca gga acc ccg atg gaa ctg 739
Ile Ile Asp Arg Gly Lys Glu Val Ala Ser Gly Thr Pro Met Glu Leu
200 205 210
cgc gcc cgt tac acc aca aca gaa ttg act ctt aga aca aac gac cct 787
Arg Ala Arg Tyr Thr Thr Thr Glu Leu Thr Leu Arg Thr Asn Asp Pro
215 220 225
act cat tcg ggt aaa gag ttg gcc cac ttg agc cca gaa atc gac ggt 835
Thr His Ser Gly Lys Glu Leu Ala His Leu Ser Pro Glu Ile Asp Gly
230 235 240 245
gac cga ctg cgg atc aag ttg gaa aat ggg ctc gaa gct gcg cgc ctg 883
Asp Arg Leu Arg Ile Lys Leu Glu Asn Gly Leu Glu Ala Ala Arg Leu
250 255 260
gca aca gaa cta gat ggg gtt ctc gac gta gag atc cgc cac ggt tcc 931
Ala Thr Glu Leu Asp Gly Val Leu Asp Val Glu Ile Arg His Gly Ser
265 270 275
atg gac gat gta ttt cta gca gtt aca gct gaa cgg aaa cga tca 976
Met Asp Asp Val Phe Leu Ala Val Thr Ala Glu Arg Lys Arg Ser
280 285 290
tgattacagt tctgacacgc aga 999
<210> 352
<211> 292
<212> PRT
<213> Corynebacterium glutamicum
<400> 352
Met Ser Pro Ile Leu Lys Val Arg Asp Leu Val Lys Arg Tyr Gly Asp
1 5 10 15
Thr Val Ala Val Asp Gly Leu Asn Phe Asp Val Ser Gln Gly Glu Ile
20 25 30
Phe Ala Phe Leu Gly Glu Asn Gly Ala Gly Lys Thr Thr Thr Ile Ser
35 40 45
Cys Leu Ile Gly Ile Asp Gln Ala Thr Ser Gly Glu Ile Glu Leu Gln
50 55 60
Gly Gly Gln Val Asp Ser Glu Lys Leu Gly Val Val Phe Gln Gln Ser
65 70 75 80
Val Leu Asp Pro Leu Leu Ser Ala Lys Glu Asn Leu Glu Thr Arg Gly
85 90 95
Gln Leu Tyr Pro Gly Val Gly Lys Gln Arg Val Ala Gln Leu Ile Glu
100 105 110
Gln Ile Gly Met Glu Gly Phe Ala Asp Arg Arg Tyr Gly Val Leu Ser
115 120 125
Gly Gly Glu Lys Arg Arg Thr Asp Ile Ala Arg Ala Leu Leu His Ser
130 135 140
Pro Asp Ile Leu Phe Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro Arg
145 150 155 160
Ser Arg Arg Gln Val Trp Asp Thr Ile Asn Ser Leu Arg Asn Asp Val
165 170 175
Gly Leu Thr Val Phe Leu Thr Thr His Tyr Met Glu Glu Thr Glu Leu
180 185 190
Ala Asp Ser Val Leu Ile Ile Asp Arg Gly Lys Glu Val Ala Ser Gly
195 200 205
Thr Pro Met Glu Leu Arg Ala Arg Tyr Thr Thr Thr Glu Leu Thr Leu
210 215 220
Arg Thr Asn Asp Pro Thr His Ser Gly Lys Glu Leu Ala His Leu Ser
225 230 235 240
Pro Glu Ile Asp Gly Asp Arg Leu Arg Ile Lys Leu Glu Asn Gly Leu
245 250 255
Glu Ala Ala Arg Leu Ala Thr Glu Leu Asp Gly Val Leu Asp Val Glu
260 265 270
Ile Arg His Gly Ser Met Asp Asp Val Phe Leu Ala Val Thr Ala Glu
275 280 285
Arg Lys Arg Ser
290
<210> 353
<211> 1920
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1897)
<223> RXA02224
<400> 353
gcttcgtcga ggccggaaaa ccgtcgtcat tacgtcgaac ccgacgtggc acggcgtcgc 60
aaagcagatg caatctgatt tttcggaagg ggtgaagtag atg gcg cag cat gag 115
Met Ala Gln His Glu
1 5
cgc gtt gcg gat gcg ctg cag ccg gcg tcg ttg gcg gag tcg tgg cgt 163
Arg Val Ala Asp Ala Leu Gln Pro Ala Ser Leu Ala Glu Ser Trp Arg
10 15 20
gag ctg aaa acg atg cct tcg ggg ccc aag gcc tgg tgg tat gtg agt 211
Glu Leu Lys Thr Met Pro Ser Gly Pro Lys Ala Trp Trp Tyr Val Ser
25 30 35
ttc gtg gtt att agc gtg gtc acg gtc gtg gcg atg gtc ggc acg tcc 259
Phe Val Val Ile Ser Val Val Thr Val Val Ala Met Val Gly Thr Ser
40 45 50
aac ttg ttg ggc tat tcc gtt gat ctg atc aat ggg cag tcg ttg ccg 307
Asn Leu Leu Gly Tyr Ser Val Asp Leu Ile Asn Gly Gln Ser Leu Pro
55 60 65
ctg atc ggt tca gga tcg acc gca atg atc tgg ttg ctt ggt ttg gtg 355
Leu Ile Gly Ser Gly Ser Thr Ala Met Ile Trp Leu Leu Gly Leu Val
70 75 80 85
ggc gct gga att tta gca gaa act gcc ggt cgc gcg ctg ctg caa ttg 403
Gly Ala Gly Ile Leu Ala Glu Thr Ala Gly Arg Ala Leu Leu Gln Leu
90 95 100
gtg atc aac acc ttg gca cgt cgc ctg tcg gtg gat ctg cgg aaa gct 451
Val Ile Asn Thr Leu Ala Arg Arg Leu Ser Val Asp Leu Arg Lys Ala
105 110 115
gcg ctg tct tcg gcg ttg cgt gca ccg gtt cct gat gtc atg gaa ttg 499
Ala Leu Ser Ser Ala Leu Arg Ala Pro Val Pro Asp Val Met Glu Leu
120 125 130
ggc acg gga aac gtg att agc cgc ctg acg caa gac atc gat aac act 547
Gly Thr Gly Asn Val Ile Ser Arg Leu Thr Gln Asp Ile Asp Asn Thr
135 140 145
gtg cgc atc gtc ggc atg gta ggt gtg cgt ttg gtg atc acc att ttg 595
Val Arg Ile Val Gly Met Val Gly Val Arg Leu Val Ile Thr Ile Leu
150 155 160 165
att ctg ccc agc tcc ttg ttc gcg ttg atg acc att cac tgg acc ttt 643
Ile Leu Pro Ser Ser Leu Phe Ala Leu Met Thr Ile His Trp Thr Phe
170 175 180
gtg atc ctg ttc atc gca gtg att gtg gtg ctg att ccc agc ggt cgg 691
Val Ile Leu Phe Ile Ala Val Ile Val Val Leu Ile Pro Ser Gly Arg
185 190 195
aaa gcc gtg cga gct att cct tcg gca aca aat att gtg tcc agt acg 739
Lys Ala Val Arg Ala Ile Pro Ser Ala Thr Asn Ile Val Ser Ser Thr
200 205 210
gag gcg cgt cga aac aat ctg ctc ctc gat acg atc cgt ggc att gaa 787
Glu Ala Arg Arg Asn Asn Leu Leu Leu Asp Thr Ile Arg Gly Ile Glu
215 220 225
aca ctg cgt gtg ctc aag ctc ggt gcg tgg ggt gtg cag cgg atg cgc 835
Thr Leu Arg Val Leu Lys Leu Gly Ala Trp Gly Val Gln Arg Met Arg
230 235 240 245
caa gcg tcg tgg act gcg gtg caa gca aca gct gat cgc gcg ccg att 883
Gln Ala Ser Trp Thr Ala Val Gln Ala Thr Ala Asp Arg Ala Pro Ile
250 255 260
ttc act cgt ctg ctc gcc ctt ggt tcg att gct tat ggc ctg ctg cta 931
Phe Thr Arg Leu Leu Ala Leu Gly Ser Ile Ala Tyr Gly Leu Leu Leu
265 270 275
att ggc gtg ttt ggg ctc agt gcg ttt tgg gtt gcc cag gat gcg atg 979
Ile Gly Val Phe Gly Leu Ser Ala Phe Trp Val Ala Gln Asp Ala Met
280 285 290
agc att gga gcg gca acg gca gca gtt ttc gtg gtt gtg cgc atg gaa 1027
Ser Ile Gly Ala Ala Thr Ala Ala Val Phe Val Val Val Arg Met Glu
295 300 305
att cac gtg ttc aac gtg ctg ttc ttc gca tcg gaa att cag agt gcg 1075
Ile His Val Phe Asn Val Leu Phe Phe Ala Ser Glu Ile Gln Ser Ala
310 315 320 325
tct act tct ctt ggt cgc gcg gtg tcc ctt gcc cag atg gct cgt cgc 1123
Ser Thr Ser Leu Gly Arg Ala Val Ser Leu Ala Gln Met Ala Arg Arg
330 335 340
acc gaa cag ctg tct gag tct gcc gat tgc aca gaa cca ccc tcc gtg 1171
Thr Glu Gln Leu Ser Glu Ser Ala Asp Cys Thr Glu Pro Pro Ser Val
345 350 355
act gtg cag gac gtg acg ttt aaa tat ccc ggc ggc gtg gcc att ttg 1219
Thr Val Gln Asp Val Thr Phe Lys Tyr Pro Gly Gly Val Ala Ile Leu
360 365 370
gag gat ttc aat ctg gtc ttg gaa gca gga aca acc aca gcg ctg gtc 1267
Glu Asp Phe Asn Leu Val Leu Glu Ala Gly Thr Thr Thr Ala Leu Val
375 380 385
ggt act tct ggt gcg gga aaa tcc acg ctc gcg ggc gtc att gcg ggg 1315
Gly Thr Ser Gly Ala Gly Lys Ser Thr Leu Ala Gly Val Ile Ala Gly
390 395 400 405
ctg cag cgc cct gat tcc ggc gcc gtt ttg gtc ggg ggc atc aac acc 1363
Leu Gln Arg Pro Asp Ser Gly Ala Val Leu Val Gly Gly Ile Asn Thr
410 415 420
gcc acc gtc acc gac acg tgg act acc cgc cag gtt gcg ctg atc agc 1411
Ala Thr Val Thr Asp Thr Trp Thr Thr Arg Gln Val Ala Leu Ile Ser
425 430 435
cag gaa gtc cac ctt ttc gca ggc act ctg gca gag gat ctt cgc atg 1459
Gln Glu Val His Leu Phe Ala Gly Thr Leu Ala Glu Asp Leu Arg Met
440 445 450
gcc aat gcg cac gcc acc gac gcg cag ctc cac gca gcg ctc gag tcg 1507
Ala Asn Ala His Ala Thr Asp Ala Gln Leu His Ala Ala Leu Glu Ser
455 460 465
gtc ggg ctc ggg caa atg aca act gct ttt cga cgt ttc ttt cca tcc 1555
Val Gly Leu Gly Gln Met Thr Thr Ala Phe Arg Arg Phe Phe Pro Ser
470 475 480 485
gga tta gac acc aaa att ggc gcc ggc gca gaa gaa ctc acc cct gaa 1603
Gly Leu Asp Thr Lys Ile Gly Ala Gly Ala Glu Glu Leu Thr Pro Glu
490 495 500
atc caa cag caa atc tct ctt gcc cgc atc gtg ctc cgc aat cca cct 1651
Ile Gln Gln Gln Ile Ser Leu Ala Arg Ile Val Leu Arg Asn Pro Pro
505 510 515
gtg ttg atc atg gat gaa gcc acc agt gaa gcc ggc agc gat gat gcc 1699
Val Leu Ile Met Asp Glu Ala Thr Ser Glu Ala Gly Ser Asp Asp Ala
520 525 530
cgc atg ttg gaa aaa gcc gcc aca gaa atc gca cga aac cgc acc acc 1747
Arg Met Leu Glu Lys Ala Ala Thr Glu Ile Ala Arg Asn Arg Thr Thr
535 540 545
ttg gtt gtt gcg cac cgc ctt gac caa gca gtt gtc gca gat cgc atc 1795
Leu Val Val Ala His Arg Leu Asp Gln Ala Val Val Ala Asp Arg Ile
550 555 560 565
atc gtg atg gaa caa ggc aca atc acc gaa gac ggc act cac cag gaa 1843
Ile Val Met Glu Gln Gly Thr Ile Thr Glu Asp Gly Thr His Gln Glu
570 575 580
tta ctt gct ttt gag ggc cgc tac gcg cag ctg tat caa cga tgg agt 1891
Leu Leu Ala Phe Glu Gly Arg Tyr Ala Gln Leu Tyr Gln Arg Trp Ser
585 590 595
gct caa tagttcaaat ccaccacaaa ctc 1920
Ala Gln
<210> 354
<211> 599
<212> PRT
<213> Corynebacterium glutamicum
<400> 354
Met Ala Gln His Glu Arg Val Ala Asp Ala Leu Gln Pro Ala Ser Leu
1 5 10 15
Ala Glu Ser Trp Arg Glu Leu Lys Thr Met Pro Ser Gly Pro Lys Ala
20 25 30
Trp Trp Tyr Val Ser Phe Val Val Ile Ser Val Val Thr Val Val Ala
35 40 45
Met Val Gly Thr Ser Asn Leu Leu Gly Tyr Ser Val Asp Leu Ile Asn
50 55 60
Gly Gln Ser Leu Pro Leu Ile Gly Ser Gly Ser Thr Ala Met Ile Trp
65 70 75 80
Leu Leu Gly Leu Val Gly Ala Gly Ile Leu Ala Glu Thr Ala Gly Arg
85 90 95
Ala Leu Leu Gln Leu Val Ile Asn Thr Leu Ala Arg Arg Leu Ser Val
100 105 110
Asp Leu Arg Lys Ala Ala Leu Ser Ser Ala Leu Arg Ala Pro Val Pro
115 120 125
Asp Val Met Glu Leu Gly Thr Gly Asn Val Ile Ser Arg Leu Thr Gln
130 135 140
Asp Ile Asp Asn Thr Val Arg Ile Val Gly Met Val Gly Val Arg Leu
145 150 155 160
Val Ile Thr Ile Leu Ile Leu Pro Ser Ser Leu Phe Ala Leu Met Thr
165 170 175
Ile His Trp Thr Phe Val Ile Leu Phe Ile Ala Val Ile Val Val Leu
180 185 190
Ile Pro Ser Gly Arg Lys Ala Val Arg Ala Ile Pro Ser Ala Thr Asn
195 200 205
Ile Val Ser Ser Thr Glu Ala Arg Arg Asn Asn Leu Leu Leu Asp Thr
210 215 220
Ile Arg Gly Ile Glu Thr Leu Arg Val Leu Lys Leu Gly Ala Trp Gly
225 230 235 240
Val Gln Arg Met Arg Gln Ala Ser Trp Thr Ala Val Gln Ala Thr Ala
245 250 255
Asp Arg Ala Pro Ile Phe Thr Arg Leu Leu Ala Leu Gly Ser Ile Ala
260 265 270
Tyr Gly Leu Leu Leu Ile Gly Val Phe Gly Leu Ser Ala Phe Trp Val
275 280 285
Ala Gln Asp Ala Met Ser Ile Gly Ala Ala Thr Ala Ala Val Phe Val
290 295 300
Val Val Arg Met Glu Ile His Val Phe Asn Val Leu Phe Phe Ala Ser
305 310 315 320
Glu Ile Gln Ser Ala Ser Thr Ser Leu Gly Arg Ala Val Ser Leu Ala
325 330 335
Gln Met Ala Arg Arg Thr Glu Gln Leu Ser Glu Ser Ala Asp Cys Thr
340 345 350
Glu Pro Pro Ser Val Thr Val Gln Asp Val Thr Phe Lys Tyr Pro Gly
355 360 365
Gly Val Ala Ile Leu Glu Asp Phe Asn Leu Val Leu Glu Ala Gly Thr
370 375 380
Thr Thr Ala Leu Val Gly Thr Ser Gly Ala Gly Lys Ser Thr Leu Ala
385 390 395 400
Gly Val Ile Ala Gly Leu Gln Arg Pro Asp Ser Gly Ala Val Leu Val
405 410 415
Gly Gly Ile Asn Thr Ala Thr Val Thr Asp Thr Trp Thr Thr Arg Gln
420 425 430
Val Ala Leu Ile Ser Gln Glu Val His Leu Phe Ala Gly Thr Leu Ala
435 440 445
Glu Asp Leu Arg Met Ala Asn Ala His Ala Thr Asp Ala Gln Leu His
450 455 460
Ala Ala Leu Glu Ser Val Gly Leu Gly Gln Met Thr Thr Ala Phe Arg
465 470 475 480
Arg Phe Phe Pro Ser Gly Leu Asp Thr Lys Ile Gly Ala Gly Ala Glu
485 490 495
Glu Leu Thr Pro Glu Ile Gln Gln Gln Ile Ser Leu Ala Arg Ile Val
500 505 510
Leu Arg Asn Pro Pro Val Leu Ile Met Asp Glu Ala Thr Ser Glu Ala
515 520 525
Gly Ser Asp Asp Ala Arg Met Leu Glu Lys Ala Ala Thr Glu Ile Ala
530 535 540
Arg Asn Arg Thr Thr Leu Val Val Ala His Arg Leu Asp Gln Ala Val
545 550 555 560
Val Ala Asp Arg Ile Ile Val Met Glu Gln Gly Thr Ile Thr Glu Asp
565 570 575
Gly Thr His Gln Glu Leu Leu Ala Phe Glu Gly Arg Tyr Ala Gln Leu
580 585 590
Tyr Gln Arg Trp Ser Ala Gln
595
<210> 355
<211> 1653
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1630)
<223> RXN01602
<400> 355
tgcaggccac atgcctccca gtgccgtctc tgcacgttga ttttcccctg ccacgactgg 60
tcgcagggcg actttctagc acttttaaag gaatttttta atg gct aaa acc cat 115
Met Ala Lys Thr His
1 5
att cgg tta cag gac ctt tcc ctg tca tac acc tca acc ccg tta att 163
Ile Arg Leu Gln Asp Leu Ser Leu Ser Tyr Thr Ser Thr Pro Leu Ile
10 15 20
acg aag ctc aat atc act gtt tct tct gga cag tgc gca gtg att gtt 211
Thr Lys Leu Asn Ile Thr Val Ser Ser Gly Gln Cys Ala Val Ile Val
25 30 35
ggt gag aat ggt cga ggt aaa acc aca ctt ctg cga gca ctg gct cga 259
Gly Glu Asn Gly Arg Gly Lys Thr Thr Leu Leu Arg Ala Leu Ala Arg
40 45 50
gaa ttc ccg cca tct gca ggt gag att ctc act cat ggc acg gta gca 307
Glu Phe Pro Pro Ser Ala Gly Glu Ile Leu Thr His Gly Thr Val Ala
55 60 65
att gct cat caa cac atg cct gca ggt gat ctg tcc gtc gga gag atc 355
Ile Ala His Gln His Met Pro Ala Gly Asp Leu Ser Val Gly Glu Ile
70 75 80 85
tgt gat gag gca att cgt gat tca aag aat gct ctc gaa gag ctt gag 403
Cys Asp Glu Ala Ile Arg Asp Ser Lys Asn Ala Leu Glu Glu Leu Glu
90 95 100
aga gct gga gct cta ctt gag aca aac act gcg cac gca ctt gat gga 451
Arg Ala Gly Ala Leu Leu Glu Thr Asn Thr Ala His Ala Leu Asp Gly
105 110 115
tat caa caa gcc ctt gat gcc gct gaa gtg ctt gac gca tgg aac gct 499
Tyr Gln Gln Ala Leu Asp Ala Ala Glu Val Leu Asp Ala Trp Asn Ala
120 125 130
gaa cat cga tta gaa aaa gct ctg cgc agc ttt ggc gcg atc acc gat 547
Glu His Arg Leu Glu Lys Ala Leu Arg Ser Phe Gly Ala Ile Thr Asp
135 140 145
aga tcc cgt gca ctc agt gag cta tcg atc ggg caa agg tat cgg gta 595
Arg Ser Arg Ala Leu Ser Glu Leu Ser Ile Gly Gln Arg Tyr Arg Val
150 155 160 165
cgg ctg gcc tgc ctc atc ggt ggc gat gct gat att ttg ctt ctc gat 643
Arg Leu Ala Cys Leu Ile Gly Gly Asp Ala Asp Ile Leu Leu Leu Asp
170 175 180
gaa ccc acc aat cat ctt gac cgg ggc gcg ctt aac tat ctc acc gaa 691
Glu Pro Thr Asn His Leu Asp Arg Gly Ala Leu Asn Tyr Leu Thr Glu
185 190 195
gcc ata acc tcc cac aaa ggt gtg gta ctt gtt gtt tct cat gat caa 739
Ala Ile Thr Ser His Lys Gly Val Val Leu Val Val Ser His Asp Gln
200 205 210
gca ctg atc aaa gat gtc gcg gat ttc atc atc gat att gat tca acc 787
Ala Leu Ile Lys Asp Val Ala Asp Phe Ile Ile Asp Ile Asp Ser Thr
215 220 225
cca gac ggc cta cca cgg atc tat cat gag ggt ttt gat tct tat cga 835
Pro Asp Gly Leu Pro Arg Ile Tyr His Glu Gly Phe Asp Ser Tyr Arg
230 235 240 245
cgc caa agg agt gcg ctt ctt gaa act tgg agg cag gat tat gcc gct 883
Arg Gln Arg Ser Ala Leu Leu Glu Thr Trp Arg Gln Asp Tyr Ala Ala
250 255 260
gca caa act gtg caa cag caa ttg cag gag gat cta gag cac gca cgc 931
Ala Gln Thr Val Gln Gln Gln Leu Gln Glu Asp Leu Glu His Ala Arg
265 270 275
cag cgg gtg aat tct tcg tgg aaa cct cca aaa gga acg gga aaa cac 979
Gln Arg Val Asn Ser Ser Trp Lys Pro Pro Lys Gly Thr Gly Lys His
280 285 290
act cgc gca tct cgg gct ccc gga gtg gtg cag gcc tta aag cga gca 1027
Thr Arg Ala Ser Arg Ala Pro Gly Val Val Gln Ala Leu Lys Arg Ala
295 300 305
cag gat gcg ttg gat agc aaa gcg ttg gac gtt ccc ccg gct ccg gcc 1075
Gln Asp Ala Leu Asp Ser Lys Ala Leu Asp Val Pro Pro Ala Pro Ala
310 315 320 325
cca ttg ctt ctg cct acc ttg aaa gtg cga cca gat aaa ccc atg gtg 1123
Pro Leu Leu Leu Pro Thr Leu Lys Val Arg Pro Asp Lys Pro Met Val
330 335 340
gac ttt tcg gac ctt ttt gta ccc cac cgc ttg cgt ctg cca ggc tca 1171
Asp Phe Ser Asp Leu Phe Val Pro His Arg Leu Arg Leu Pro Gly Ser
345 350 355
cat tca gtg gta tca ggt gac aaa ata gtg atc act ggt gac aac ggc 1219
His Ser Val Val Ser Gly Asp Lys Ile Val Ile Thr Gly Asp Asn Gly
360 365 370
gct ggc aaa tca acg ctc atc gaa gtc ttg tct ggg gtt ttg act ccg 1267
Ala Gly Lys Ser Thr Leu Ile Glu Val Leu Ser Gly Val Leu Thr Pro
375 380 385
gca agt ggt tcg gtt gca aac cat gcc cga act ggg gtt ctc ggc caa 1315
Ala Ser Gly Ser Val Ala Asn His Ala Arg Thr Gly Val Leu Gly Gln
390 395 400 405
gaa tca ctt gtc ggc gag gtg cca tca ata gca cga gat cac gca gtt 1363
Glu Ser Leu Val Gly Glu Val Pro Ser Ile Ala Arg Asp His Ala Val
410 415 420
aag tgg gga ctt tta agt gtt gag gag agc cga ttt gcc cta cag gaa 1411
Lys Trp Gly Leu Leu Ser Val Glu Glu Ser Arg Phe Ala Leu Gln Glu
425 430 435
ttc tca att ggt caa cgc aga aga cta gat ttg gcc atg tcg tta gct 1459
Phe Ser Ile Gly Gln Arg Arg Arg Leu Asp Leu Ala Met Ser Leu Ala
440 445 450
ggc aat cct gaa ctg ttg ctt ctc gat gaa cct tcg aac cat ctg tct 1507
Gly Asn Pro Glu Leu Leu Leu Leu Asp Glu Pro Ser Asn His Leu Ser
455 460 465
atg cac ttg gtt tcc gca ctt aca gag tgg ctg gac acg acc gcg gct 1555
Met His Leu Val Ser Ala Leu Thr Glu Trp Leu Asp Thr Thr Ala Ala
470 475 480 485
gca gtg atc atg gta acg cat gat cga cag cta ctc cgc gat acg gct 1603
Ala Val Ile Met Val Thr His Asp Arg Gln Leu Leu Arg Asp Thr Ala
490 495 500
cat tgg agg cac atc gag ttg aaa tct taagaattcg caagggcttt 1650
His Trp Arg His Ile Glu Leu Lys Ser
505 510
cac 1653
<210> 356
<211> 510
<212> PRT
<213> Corynebacterium glutamicum
<400> 356
Met Ala Lys Thr His Ile Arg Leu Gln Asp Leu Ser Leu Ser Tyr Thr
1 5 10 15
Ser Thr Pro Leu Ile Thr Lys Leu Asn Ile Thr Val Ser Ser Gly Gln
20 25 30
Cys Ala Val Ile Val Gly Glu Asn Gly Arg Gly Lys Thr Thr Leu Leu
35 40 45
Arg Ala Leu Ala Arg Glu Phe Pro Pro Ser Ala Gly Glu Ile Leu Thr
50 55 60
His Gly Thr Val Ala Ile Ala His Gln His Met Pro Ala Gly Asp Leu
65 70 75 80
Ser Val Gly Glu Ile Cys Asp Glu Ala Ile Arg Asp Ser Lys Asn Ala
85 90 95
Leu Glu Glu Leu Glu Arg Ala Gly Ala Leu Leu Glu Thr Asn Thr Ala
100 105 110
His Ala Leu Asp Gly Tyr Gln Gln Ala Leu Asp Ala Ala Glu Val Leu
115 120 125
Asp Ala Trp Asn Ala Glu His Arg Leu Glu Lys Ala Leu Arg Ser Phe
130 135 140
Gly Ala Ile Thr Asp Arg Ser Arg Ala Leu Ser Glu Leu Ser Ile Gly
145 150 155 160
Gln Arg Tyr Arg Val Arg Leu Ala Cys Leu Ile Gly Gly Asp Ala Asp
165 170 175
Ile Leu Leu Leu Asp Glu Pro Thr Asn His Leu Asp Arg Gly Ala Leu
180 185 190
Asn Tyr Leu Thr Glu Ala Ile Thr Ser His Lys Gly Val Val Leu Val
195 200 205
Val Ser His Asp Gln Ala Leu Ile Lys Asp Val Ala Asp Phe Ile Ile
210 215 220
Asp Ile Asp Ser Thr Pro Asp Gly Leu Pro Arg Ile Tyr His Glu Gly
225 230 235 240
Phe Asp Ser Tyr Arg Arg Gln Arg Ser Ala Leu Leu Glu Thr Trp Arg
245 250 255
Gln Asp Tyr Ala Ala Ala Gln Thr Val Gln Gln Gln Leu Gln Glu Asp
260 265 270
Leu Glu His Ala Arg Gln Arg Val Asn Ser Ser Trp Lys Pro Pro Lys
275 280 285
Gly Thr Gly Lys His Thr Arg Ala Ser Arg Ala Pro Gly Val Val Gln
290 295 300
Ala Leu Lys Arg Ala Gln Asp Ala Leu Asp Ser Lys Ala Leu Asp Val
305 310 315 320
Pro Pro Ala Pro Ala Pro Leu Leu Leu Pro Thr Leu Lys Val Arg Pro
325 330 335
Asp Lys Pro Met Val Asp Phe Ser Asp Leu Phe Val Pro His Arg Leu
340 345 350
Arg Leu Pro Gly Ser His Ser Val Val Ser Gly Asp Lys Ile Val Ile
355 360 365
Thr Gly Asp Asn Gly Ala Gly Lys Ser Thr Leu Ile Glu Val Leu Ser
370 375 380
Gly Val Leu Thr Pro Ala Ser Gly Ser Val Ala Asn His Ala Arg Thr
385 390 395 400
Gly Val Leu Gly Gln Glu Ser Leu Val Gly Glu Val Pro Ser Ile Ala
405 410 415
Arg Asp His Ala Val Lys Trp Gly Leu Leu Ser Val Glu Glu Ser Arg
420 425 430
Phe Ala Leu Gln Glu Phe Ser Ile Gly Gln Arg Arg Arg Leu Asp Leu
435 440 445
Ala Met Ser Leu Ala Gly Asn Pro Glu Leu Leu Leu Leu Asp Glu Pro
450 455 460
Ser Asn His Leu Ser Met His Leu Val Ser Ala Leu Thr Glu Trp Leu
465 470 475 480
Asp Thr Thr Ala Ala Ala Val Ile Met Val Thr His Asp Arg Gln Leu
485 490 495
Leu Arg Asp Thr Ala His Trp Arg His Ile Glu Leu Lys Ser
500 505 510
<210> 357
<211> 879
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(856)
<223> RXN02515
<400> 357
gtggctaagc acagttactt ggccaagctg ggcggcagaa aaaccggccc agctaatact 60
tcagtttaaa attcgcttca accctgaaag attgtgacag atg agc act ctt gaa 115
Met Ser Thr Leu Glu
1 5
atc cgt aac ctg cac gca cag gtc ctg ccg tcc gat gag tcc gct gag 163
Ile Arg Asn Leu His Ala Gln Val Leu Pro Ser Asp Glu Ser Ala Glu
10 15 20
cct aag gaa atc ctc aag ggc gtc aac ctc acc atc aac tct ggt gag 211
Pro Lys Glu Ile Leu Lys Gly Val Asn Leu Thr Ile Asn Ser Gly Glu
25 30 35
atc cac gcc atc atg ggc cct aac ggt tcc ggc aag tcc act ctt gct 259
Ile His Ala Ile Met Gly Pro Asn Gly Ser Gly Lys Ser Thr Leu Ala
40 45 50
tac acc ctt ggt gga cac cca cgc tac gag gta acc gca ggc gag gtc 307
Tyr Thr Leu Gly Gly His Pro Arg Tyr Glu Val Thr Ala Gly Glu Val
55 60 65
ctc ctc gac ggc gag aac atc ctg gag atg gaa gtt gat gag cgt gca 355
Leu Leu Asp Gly Glu Asn Ile Leu Glu Met Glu Val Asp Glu Arg Ala
70 75 80 85
cgc gct ggt ctc ttc ctg gcc atg cag tat cca act gaa atc cct ggc 403
Arg Ala Gly Leu Phe Leu Ala Met Gln Tyr Pro Thr Glu Ile Pro Gly
90 95 100
gtt tcc gtt gct aac ttc ctg cgt tcc gca gcg acc gca atc cgc ggc 451
Val Ser Val Ala Asn Phe Leu Arg Ser Ala Ala Thr Ala Ile Arg Gly
105 110 115
gag gct cct aag ctt cgc gag tgg gtt aag gaa gtc cgc acc gct cag 499
Glu Ala Pro Lys Leu Arg Glu Trp Val Lys Glu Val Arg Thr Ala Gln
120 125 130
gaa gct ctg gca att gac cct gag ttc tcc aac cgc tca gtc aac gaa 547
Glu Ala Leu Ala Ile Asp Pro Glu Phe Ser Asn Arg Ser Val Asn Glu
135 140 145
ggt ttc tcc ggt ggc gag aag aag cgc cac gag gtt ctg cag ctt gat 595
Gly Phe Ser Gly Gly Glu Lys Lys Arg His Glu Val Leu Gln Leu Asp
150 155 160 165
ctg ctg aag cca aag ttc gcg atc atg gat gag acc gac tcc ggc ctt 643
Leu Leu Lys Pro Lys Phe Ala Ile Met Asp Glu Thr Asp Ser Gly Leu
170 175 180
gac gtg gat gca ctg cgc att gtt tcc gag ggc atc aac tcc tac aag 691
Asp Val Asp Ala Leu Arg Ile Val Ser Glu Gly Ile Asn Ser Tyr Lys
185 190 195
cag gag acc gaa ggt ggc atc ttg atg atc acc cac tac aag cgc atc 739
Gln Glu Thr Glu Gly Gly Ile Leu Met Ile Thr His Tyr Lys Arg Ile
200 205 210
ctc aac tac gtt aag cct gac ttc att cac gtt ttc gcg aat ggc cag 787
Leu Asn Tyr Val Lys Pro Asp Phe Ile His Val Phe Ala Asn Gly Gln
215 220 225
att gtg acc acc ggt ggc gct gag ctt gct gac aag ctc gag gct gac 835
Ile Val Thr Thr Gly Gly Ala Glu Leu Ala Asp Lys Leu Glu Ala Asp
230 235 240 245
ggc tac gac cag ttc atc aag taacatgtcc gatttcctca atg 879
Gly Tyr Asp Gln Phe Ile Lys
250
<210> 358
<211> 252
<212> PRT
<213> Corynebacterium glutamicum
<400> 358
Met Ser Thr Leu Glu Ile Arg Asn Leu His Ala Gln Val Leu Pro Ser
1 5 10 15
Asp Glu Ser Ala Glu Pro Lys Glu Ile Leu Lys Gly Val Asn Leu Thr
20 25 30
Ile Asn Ser Gly Glu Ile His Ala Ile Met Gly Pro Asn Gly Ser Gly
35 40 45
Lys Ser Thr Leu Ala Tyr Thr Leu Gly Gly His Pro Arg Tyr Glu Val
50 55 60
Thr Ala Gly Glu Val Leu Leu Asp Gly Glu Asn Ile Leu Glu Met Glu
65 70 75 80
Val Asp Glu Arg Ala Arg Ala Gly Leu Phe Leu Ala Met Gln Tyr Pro
85 90 95
Thr Glu Ile Pro Gly Val Ser Val Ala Asn Phe Leu Arg Ser Ala Ala
100 105 110
Thr Ala Ile Arg Gly Glu Ala Pro Lys Leu Arg Glu Trp Val Lys Glu
115 120 125
Val Arg Thr Ala Gln Glu Ala Leu Ala Ile Asp Pro Glu Phe Ser Asn
130 135 140
Arg Ser Val Asn Glu Gly Phe Ser Gly Gly Glu Lys Lys Arg His Glu
145 150 155 160
Val Leu Gln Leu Asp Leu Leu Lys Pro Lys Phe Ala Ile Met Asp Glu
165 170 175
Thr Asp Ser Gly Leu Asp Val Asp Ala Leu Arg Ile Val Ser Glu Gly
180 185 190
Ile Asn Ser Tyr Lys Gln Glu Thr Glu Gly Gly Ile Leu Met Ile Thr
195 200 205
His Tyr Lys Arg Ile Leu Asn Tyr Val Lys Pro Asp Phe Ile His Val
210 215 220
Phe Ala Asn Gly Gln Ile Val Thr Thr Gly Gly Ala Glu Leu Ala Asp
225 230 235 240
Lys Leu Glu Ala Asp Gly Tyr Asp Gln Phe Ile Lys
245 250
<210> 359
<211> 1386
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1363)
<223> RXN00525
<400> 359
ccatcgtgtt tattactcac aaccctgagc ttgctgatga atctgatcgg gtggtcacca 60
tggttgacgg gcgcatcatt gggtctgagg tgaaacactc atg agc ctt gca gaa 115
Met Ser Leu Ala Glu
1 5
tca att ctt ttg gcg ctc acc agc ctg aga agc aac aag atg cgt gca 163
Ser Ile Leu Leu Ala Leu Thr Ser Leu Arg Ser Asn Lys Met Arg Ala
10 15 20
ttg ttg acg ctg tta gga gtc atc att ggt atc gca tca gtc atc gga 211
Leu Leu Thr Leu Leu Gly Val Ile Ile Gly Ile Ala Ser Val Ile Gly
25 30 35
att ttg acc att ggt aaa gcc ctg cag gat caa act ttg aat agt ttg 259
Ile Leu Thr Ile Gly Lys Ala Leu Gln Asp Gln Thr Leu Asn Ser Leu
40 45 50
gaa agc ttg ggc gcg aat gat ctg tcg gcg cag gtg gag gaa cgc ccc 307
Glu Ser Leu Gly Ala Asn Asp Leu Ser Ala Gln Val Glu Glu Arg Pro
55 60 65
gac gaa gat tcc ccc gaa ccc gat atg ttc gct ttt tct ggg gct gca 355
Asp Glu Asp Ser Pro Glu Pro Asp Met Phe Ala Phe Ser Gly Ala Ala
70 75 80 85
aac tct agt ggc aat ctg att ccg gaa gaa aca gtt gat acg ctg cgc 403
Asn Ser Ser Gly Asn Leu Ile Pro Glu Glu Thr Val Asp Thr Leu Arg
90 95 100
gat cgt ttc gca ggc agc atc acg gga atc agc gtt ggc gga atg ggt 451
Asp Arg Phe Ala Gly Ser Ile Thr Gly Ile Ser Val Gly Gly Met Gly
105 110 115
acg caa ggc act ctc atc ggc gac acc gca gat ctt aaa tcc gat ctc 499
Thr Gln Gly Thr Leu Ile Gly Asp Thr Ala Asp Leu Lys Ser Asp Leu
120 125 130
ctc ggc gtc aac gag gat tat atg tgg atg aat ggc gtc gaa atg aac 547
Leu Gly Val Asn Glu Asp Tyr Met Trp Met Asn Gly Val Glu Met Asn
135 140 145
tac ggc cgc gcc atc acg caa gac gat gtt gcc gct cag cgc ccc gtt 595
Tyr Gly Arg Ala Ile Thr Gln Asp Asp Val Ala Ala Gln Arg Pro Val
150 155 160 165
gcg gtc atc gcc cca gac acc ttt aat acg ctt ttc gac gca aac ccc 643
Ala Val Ile Ala Pro Asp Thr Phe Asn Thr Leu Phe Asp Ala Asn Pro
170 175 180
aac ctc gct ctg ggg tcc gaa gta gct ttt gaa ctc aac ggt caa gag 691
Asn Leu Ala Leu Gly Ser Glu Val Ala Phe Glu Leu Asn Gly Gln Glu
185 190 195
aca ttt ttg cgg gtt atc ggt gtg tat aaa gaa gcc gca gca ggt gga 739
Thr Phe Leu Arg Val Ile Gly Val Tyr Lys Glu Ala Ala Ala Gly Gly
200 205 210
ctt gtg gga agc aat cca acc gtc cac acc tac acc cca tat acg gtg 787
Leu Val Gly Ser Asn Pro Thr Val His Thr Tyr Thr Pro Tyr Thr Val
215 220 225
gcc aat gac atc acc cac acg gaa gat gga ttg aac acg tta agt atc 835
Ala Asn Asp Ile Thr His Thr Glu Asp Gly Leu Asn Thr Leu Ser Ile
230 235 240 245
cgt gca gct cag ggc gta gac cag gat tca ctt aag ggt tca ctg caa 883
Arg Ala Ala Gln Gly Val Asp Gln Asp Ser Leu Lys Gly Ser Leu Gln
250 255 260
acc tac ttc gac gcg ctg tac gcc aac aat gac tcg cac cac gtt gcc 931
Thr Tyr Phe Asp Ala Leu Tyr Ala Asn Asn Asp Ser His His Val Ala
265 270 275
atg ttg gac ttc cgt aaa cag atc gaa gag ttc aac acc att ctc ggc 979
Met Leu Asp Phe Arg Lys Gln Ile Glu Glu Phe Asn Thr Ile Leu Gly
280 285 290
gca atg agt ttg ggt atc tca gcc atc ggc gga att tcc ttg ctt gtc 1027
Ala Met Ser Leu Gly Ile Ser Ala Ile Gly Gly Ile Ser Leu Leu Val
295 300 305
ggt ggc atc gga gtg atg aac att atg ttg gtg tct gtc acc gag cga 1075
Gly Gly Ile Gly Val Met Asn Ile Met Leu Val Ser Val Thr Glu Arg
310 315 320 325
acc cgc gaa atc ggt gtc cga aaa gcc ctc ggc gct cgt cga cgt gac 1123
Thr Arg Glu Ile Gly Val Arg Lys Ala Leu Gly Ala Arg Arg Arg Asp
330 335 340
att cgc ctg caa ttc gtc gtt gaa gcc atg atc att tgt ttc atc ggt 1171
Ile Arg Leu Gln Phe Val Val Glu Ala Met Ile Ile Cys Phe Ile Gly
345 350 355
ggc atc ctc ggc gtg ctt ttg ggc ggc att ttg gga ttg atc atg tcc 1219
Gly Ile Leu Gly Val Leu Leu Gly Gly Ile Leu Gly Leu Ile Met Ser
360 365 370
agc gct att ggc tac att tcc ttg cca cca ctg agt gga atc gtg atc 1267
Ser Ala Ile Gly Tyr Ile Ser Leu Pro Pro Leu Ser Gly Ile Val Ile
375 380 385
gcc ttg gta ttt tcc atg gct atc ggc ctg ttt ttc ggc tac tac ccc 1315
Ala Leu Val Phe Ser Met Ala Ile Gly Leu Phe Phe Gly Tyr Tyr Pro
390 395 400 405
gcc aac aag gca gca aag ctc gat cca att gac gcc ttg cgt tat gag 1363
Ala Asn Lys Ala Ala Lys Leu Asp Pro Ile Asp Ala Leu Arg Tyr Glu
410 415 420
taaaagcctc gtttttaagg tag 1386
<210> 360
<211> 421
<212> PRT
<213> Corynebacterium glutamicum
<400> 360
Met Ser Leu Ala Glu Ser Ile Leu Leu Ala Leu Thr Ser Leu Arg Ser
1 5 10 15
Asn Lys Met Arg Ala Leu Leu Thr Leu Leu Gly Val Ile Ile Gly Ile
20 25 30
Ala Ser Val Ile Gly Ile Leu Thr Ile Gly Lys Ala Leu Gln Asp Gln
35 40 45
Thr Leu Asn Ser Leu Glu Ser Leu Gly Ala Asn Asp Leu Ser Ala Gln
50 55 60
Val Glu Glu Arg Pro Asp Glu Asp Ser Pro Glu Pro Asp Met Phe Ala
65 70 75 80
Phe Ser Gly Ala Ala Asn Ser Ser Gly Asn Leu Ile Pro Glu Glu Thr
85 90 95
Val Asp Thr Leu Arg Asp Arg Phe Ala Gly Ser Ile Thr Gly Ile Ser
100 105 110
Val Gly Gly Met Gly Thr Gln Gly Thr Leu Ile Gly Asp Thr Ala Asp
115 120 125
Leu Lys Ser Asp Leu Leu Gly Val Asn Glu Asp Tyr Met Trp Met Asn
130 135 140
Gly Val Glu Met Asn Tyr Gly Arg Ala Ile Thr Gln Asp Asp Val Ala
145 150 155 160
Ala Gln Arg Pro Val Ala Val Ile Ala Pro Asp Thr Phe Asn Thr Leu
165 170 175
Phe Asp Ala Asn Pro Asn Leu Ala Leu Gly Ser Glu Val Ala Phe Glu
180 185 190
Leu Asn Gly Gln Glu Thr Phe Leu Arg Val Ile Gly Val Tyr Lys Glu
195 200 205
Ala Ala Ala Gly Gly Leu Val Gly Ser Asn Pro Thr Val His Thr Tyr
210 215 220
Thr Pro Tyr Thr Val Ala Asn Asp Ile Thr His Thr Glu Asp Gly Leu
225 230 235 240
Asn Thr Leu Ser Ile Arg Ala Ala Gln Gly Val Asp Gln Asp Ser Leu
245 250 255
Lys Gly Ser Leu Gln Thr Tyr Phe Asp Ala Leu Tyr Ala Asn Asn Asp
260 265 270
Ser His His Val Ala Met Leu Asp Phe Arg Lys Gln Ile Glu Glu Phe
275 280 285
Asn Thr Ile Leu Gly Ala Met Ser Leu Gly Ile Ser Ala Ile Gly Gly
290 295 300
Ile Ser Leu Leu Val Gly Gly Ile Gly Val Met Asn Ile Met Leu Val
305 310 315 320
Ser Val Thr Glu Arg Thr Arg Glu Ile Gly Val Arg Lys Ala Leu Gly
325 330 335
Ala Arg Arg Arg Asp Ile Arg Leu Gln Phe Val Val Glu Ala Met Ile
340 345 350
Ile Cys Phe Ile Gly Gly Ile Leu Gly Val Leu Leu Gly Gly Ile Leu
355 360 365
Gly Leu Ile Met Ser Ser Ala Ile Gly Tyr Ile Ser Leu Pro Pro Leu
370 375 380
Ser Gly Ile Val Ile Ala Leu Val Phe Ser Met Ala Ile Gly Leu Phe
385 390 395 400
Phe Gly Tyr Tyr Pro Ala Asn Lys Ala Ala Lys Leu Asp Pro Ile Asp
405 410 415
Ala Leu Arg Tyr Glu
420
<210> 361
<211> 1815
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1792)
<223> RXN02096
<400> 361
cgcttcgacg acctcaccca cagcgatatc cgcaggaatc tcatcgcggt ttttgatgag 60
ccgttcttgt actcctcctc cataccgcga gaacatctcg atg ggt ttg gat gtc 115
Met Gly Leu Asp Val
1 5
agt gat gag cag atc gaa cac gca gcc agg ctt gcc cag gct cat gat 163
Ser Asp Glu Gln Ile Glu His Ala Ala Arg Leu Ala Gln Ala His Asp
10 15 20
ttt atc gat cgc ctt cca aac aaa tac gag gaa gtc att ggc gaa cgc 211
Phe Ile Asp Arg Leu Pro Asn Lys Tyr Glu Glu Val Ile Gly Glu Arg
25 30 35
ggc ctg acg ctt tct ggt ggt caa cgc caa cgc atc gcc ctc gca cgg 259
Gly Leu Thr Leu Ser Gly Gly Gln Arg Gln Arg Ile Ala Leu Ala Arg
40 45 50
gct ttc ctg gcg cat ccc aaa gtg ttg gtg ctt gat gat gcc acc tct 307
Ala Phe Leu Ala His Pro Lys Val Leu Val Leu Asp Asp Ala Thr Ser
55 60 65
gcc att gat gcc tcc act gag gac cgc att ttc cag gcc ttg cgc gaa 355
Ala Ile Asp Ala Ser Thr Glu Asp Arg Ile Phe Gln Ala Leu Arg Glu
70 75 80 85
gaa ctg cac gat gtc acc att ttg atc atc gcg cac cgc cac tcc act 403
Glu Leu His Asp Val Thr Ile Leu Ile Ile Ala His Arg His Ser Thr
90 95 100
ttg gag ctc ggc gat cgg gtt ggt ctg gtc gaa gat gga cgg gta aca 451
Leu Glu Leu Gly Asp Arg Val Gly Leu Val Glu Asp Gly Arg Val Thr
105 110 115
gca ctg gga ccg ttg agt gag atg cgt gat cac gct cgt ttc tcg cat 499
Ala Leu Gly Pro Leu Ser Glu Met Arg Asp His Ala Arg Phe Ser His
120 125 130
ctg atg gct ctt gat ttc cag gat tct cac gat ccg gaa ttc acc ctc 547
Leu Met Ala Leu Asp Phe Gln Asp Ser His Asp Pro Glu Phe Thr Leu
135 140 145
gac aac ggt tca cta ccc agc caa gag caa ttg tgg ccg gag gtc tcc 595
Asp Asn Gly Ser Leu Pro Ser Gln Glu Gln Leu Trp Pro Glu Val Ser
150 155 160 165
aca gaa aag cag tac aag att ctt gcg cct gcc cct ggt cga ggc cgt 643
Thr Glu Lys Gln Tyr Lys Ile Leu Ala Pro Ala Pro Gly Arg Gly Arg
170 175 180
ggc atg tcc atg cca gca acc cct gag ctg ctc gcc cag att gag gcg 691
Gly Met Ser Met Pro Ala Thr Pro Glu Leu Leu Ala Gln Ile Glu Ala
185 190 195
ctg cca gca gca acg gaa gaa aca cga gtt gat gcc ggg agg cta cgc 739
Leu Pro Ala Ala Thr Glu Glu Thr Arg Val Asp Ala Gly Arg Leu Arg
200 205 210
acc agt acc tcc ggt ttc aaa ttg ctc agt tta ttc aag cag gtc cgt 787
Thr Ser Thr Ser Gly Phe Lys Leu Leu Ser Leu Phe Lys Gln Val Arg
215 220 225
tgg ctc gtc gtc gcg gtc atc gcg ttg ttg ctg gtg ggc gta gcc gcc 835
Trp Leu Val Val Ala Val Ile Ala Leu Leu Leu Val Gly Val Ala Ala
230 235 240 245
gat cta gca ttt cca aca ctg atg cgc gca gcc atc gac aac ggt gtg 883
Asp Leu Ala Phe Pro Thr Leu Met Arg Ala Ala Ile Asp Asn Gly Val
250 255 260
caa gca caa agc acc tcc acg ttg tgg tgg atc gcc atc gca ggc agc 931
Gln Ala Gln Ser Thr Ser Thr Leu Trp Trp Ile Ala Ile Ala Gly Ser
265 270 275
gta gta gtc ctt ctg tcc tgg gcc gcc gcc gcg atc aac acg att atc 979
Val Val Val Leu Leu Ser Trp Ala Ala Ala Ala Ile Asn Thr Ile Ile
280 285 290
acg gca cgc acc ggt gaa cgg ctg ctt tac ggc ttg cgt ctg cgc tca 1027
Thr Ala Arg Thr Gly Glu Arg Leu Leu Tyr Gly Leu Arg Leu Arg Ser
295 300 305
ttt gtg cat cta ttg cgc ctg tcc atg agc tat ttc gaa cgc acc atg 1075
Phe Val His Leu Leu Arg Leu Ser Met Ser Tyr Phe Glu Arg Thr Met
310 315 320 325
tcc ggc cgc atc atg acg cgc atg acc acc gac atc gac aac ctc tcg 1123
Ser Gly Arg Ile Met Thr Arg Met Thr Thr Asp Ile Asp Asn Leu Ser
330 335 340
tcc ttc ctc caa tca ggt ctg gcg caa aca gtt gtc tct gtg ggc acg 1171
Ser Phe Leu Gln Ser Gly Leu Ala Gln Thr Val Val Ser Val Gly Thr
345 350 355
ctc atc ggt gtg gtc acc atg ctc gcc atc acc gac gca caa cta gca 1219
Leu Ile Gly Val Val Thr Met Leu Ala Ile Thr Asp Ala Gln Leu Ala
360 365 370
ctc gtt gcg ctg tcc gtg gtg ccg atc atc atc gtg ctc act ctc att 1267
Leu Val Ala Leu Ser Val Val Pro Ile Ile Ile Val Leu Thr Leu Ile
375 380 385
ttc cga cgc atc agc tcc agg ctg tac acc gct tca cgc gag caa gcc 1315
Phe Arg Arg Ile Ser Ser Arg Leu Tyr Thr Ala Ser Arg Glu Gln Ala
390 395 400 405
agc cag gtc aac gcg gta ttc cac gag tcc atc gcc ggt tta cgc acc 1363
Ser Gln Val Asn Ala Val Phe His Glu Ser Ile Ala Gly Leu Arg Thr
410 415 420
gcg cag atg cac cgc atg gaa gac caa gtc ttt gac aat tat gcg ggc 1411
Ala Gln Met His Arg Met Glu Asp Gln Val Phe Asp Asn Tyr Ala Gly
425 430 435
gaa gca gag gaa ttc cga cgc ctg cgt gtg aaa tcc cag acg gcc atc 1459
Glu Ala Glu Glu Phe Arg Arg Leu Arg Val Lys Ser Gln Thr Ala Ile
440 445 450
gcc atc tac ttc ccc ggc ctt ggc gcg ctc tct gaa atc gcc cag gca 1507
Ala Ile Tyr Phe Pro Gly Leu Gly Ala Leu Ser Glu Ile Ala Gln Ala
455 460 465
ctc gtc ctc ggt ttc ggc gca ctg caa gta acg cgc ggc gac atc tcc 1555
Leu Val Leu Gly Phe Gly Ala Leu Gln Val Thr Arg Gly Asp Ile Ser
470 475 480 485
acc ggc gta ctc gtg gca ttc gtg ctg tac atg ggc ctg atg ttc ggc 1603
Thr Gly Val Leu Val Ala Phe Val Leu Tyr Met Gly Leu Met Phe Gly
490 495 500
ccc atc caa caa cta agc caa atc ttc gac tcc tac caa caa gcc gcc 1651
Pro Ile Gln Gln Leu Ser Gln Ile Phe Asp Ser Tyr Gln Gln Ala Ala
505 510 515
gtc ggc ttc cgt cgc atc acc gaa ctg ctc gca acg cag ccc agc gtc 1699
Val Gly Phe Arg Arg Ile Thr Glu Leu Leu Ala Thr Gln Pro Ser Val
520 525 530
cag atc tgg gca cca aca ggc acg cta ggc agg ctg cca cgc agc ctt 1747
Gln Ile Trp Ala Pro Thr Gly Thr Leu Gly Arg Leu Pro Arg Ser Leu
535 540 545
tat tgc ttg acg acg tca cct tcg gct att cag acg atc cga tcc 1792
Tyr Cys Leu Thr Thr Ser Pro Ser Ala Ile Gln Thr Ile Arg Ser
550 555 560
tagacaacgt caccgtccag atc 1815
<210> 362
<211> 564
<212> PRT
<213> Corynebacterium glutamicum
<400> 362
Met Gly Leu Asp Val Ser Asp Glu Gln Ile Glu His Ala Ala Arg Leu
1 5 10 15
Ala Gln Ala His Asp Phe Ile Asp Arg Leu Pro Asn Lys Tyr Glu Glu
20 25 30
Val Ile Gly Glu Arg Gly Leu Thr Leu Ser Gly Gly Gln Arg Gln Arg
35 40 45
Ile Ala Leu Ala Arg Ala Phe Leu Ala His Pro Lys Val Leu Val Leu
50 55 60
Asp Asp Ala Thr Ser Ala Ile Asp Ala Ser Thr Glu Asp Arg Ile Phe
65 70 75 80
Gln Ala Leu Arg Glu Glu Leu His Asp Val Thr Ile Leu Ile Ile Ala
85 90 95
His Arg His Ser Thr Leu Glu Leu Gly Asp Arg Val Gly Leu Val Glu
100 105 110
Asp Gly Arg Val Thr Ala Leu Gly Pro Leu Ser Glu Met Arg Asp His
115 120 125
Ala Arg Phe Ser His Leu Met Ala Leu Asp Phe Gln Asp Ser His Asp
130 135 140
Pro Glu Phe Thr Leu Asp Asn Gly Ser Leu Pro Ser Gln Glu Gln Leu
145 150 155 160
Trp Pro Glu Val Ser Thr Glu Lys Gln Tyr Lys Ile Leu Ala Pro Ala
165 170 175
Pro Gly Arg Gly Arg Gly Met Ser Met Pro Ala Thr Pro Glu Leu Leu
180 185 190
Ala Gln Ile Glu Ala Leu Pro Ala Ala Thr Glu Glu Thr Arg Val Asp
195 200 205
Ala Gly Arg Leu Arg Thr Ser Thr Ser Gly Phe Lys Leu Leu Ser Leu
210 215 220
Phe Lys Gln Val Arg Trp Leu Val Val Ala Val Ile Ala Leu Leu Leu
225 230 235 240
Val Gly Val Ala Ala Asp Leu Ala Phe Pro Thr Leu Met Arg Ala Ala
245 250 255
Ile Asp Asn Gly Val Gln Ala Gln Ser Thr Ser Thr Leu Trp Trp Ile
260 265 270
Ala Ile Ala Gly Ser Val Val Val Leu Leu Ser Trp Ala Ala Ala Ala
275 280 285
Ile Asn Thr Ile Ile Thr Ala Arg Thr Gly Glu Arg Leu Leu Tyr Gly
290 295 300
Leu Arg Leu Arg Ser Phe Val His Leu Leu Arg Leu Ser Met Ser Tyr
305 310 315 320
Phe Glu Arg Thr Met Ser Gly Arg Ile Met Thr Arg Met Thr Thr Asp
325 330 335
Ile Asp Asn Leu Ser Ser Phe Leu Gln Ser Gly Leu Ala Gln Thr Val
340 345 350
Val Ser Val Gly Thr Leu Ile Gly Val Val Thr Met Leu Ala Ile Thr
355 360 365
Asp Ala Gln Leu Ala Leu Val Ala Leu Ser Val Val Pro Ile Ile Ile
370 375 380
Val Leu Thr Leu Ile Phe Arg Arg Ile Ser Ser Arg Leu Tyr Thr Ala
385 390 395 400
Ser Arg Glu Gln Ala Ser Gln Val Asn Ala Val Phe His Glu Ser Ile
405 410 415
Ala Gly Leu Arg Thr Ala Gln Met His Arg Met Glu Asp Gln Val Phe
420 425 430
Asp Asn Tyr Ala Gly Glu Ala Glu Glu Phe Arg Arg Leu Arg Val Lys
435 440 445
Ser Gln Thr Ala Ile Ala Ile Tyr Phe Pro Gly Leu Gly Ala Leu Ser
450 455 460
Glu Ile Ala Gln Ala Leu Val Leu Gly Phe Gly Ala Leu Gln Val Thr
465 470 475 480
Arg Gly Asp Ile Ser Thr Gly Val Leu Val Ala Phe Val Leu Tyr Met
485 490 495
Gly Leu Met Phe Gly Pro Ile Gln Gln Leu Ser Gln Ile Phe Asp Ser
500 505 510
Tyr Gln Gln Ala Ala Val Gly Phe Arg Arg Ile Thr Glu Leu Leu Ala
515 520 525
Thr Gln Pro Ser Val Gln Ile Trp Ala Pro Thr Gly Thr Leu Gly Arg
530 535 540
Leu Pro Arg Ser Leu Tyr Cys Leu Thr Thr Ser Pro Ser Ala Ile Gln
545 550 555 560
Thr Ile Arg Ser
<210> 363
<211> 1203
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1180)
<223> RXN00412
<400> 363
cttttgacga acaccacgtc gcgtacgctt cctcggggcg ttaaactatt tgtcttccag 60
cttttgtccc ccgacttttg tacgaatcga ggacaccgtc gtg tca cac acc gcg 115
Val Ser His Thr Ala
1 5
tcc aca ccg acg cca gag gaa tac tcc gcg cag caa ccc agc acc cag 163
Ser Thr Pro Thr Pro Glu Glu Tyr Ser Ala Gln Gln Pro Ser Thr Gln
10 15 20
ggc act cgc gtt gag ttc cgc ggc ata acc aaa gtc ttt agc aac aat 211
Gly Thr Arg Val Glu Phe Arg Gly Ile Thr Lys Val Phe Ser Asn Asn
25 30 35
aaa tct gct aaa acc acc gcg ctt gat aat gtc act ctc acc gta gaa 259
Lys Ser Ala Lys Thr Thr Ala Leu Asp Asn Val Thr Leu Thr Val Glu
40 45 50
ccc ggt gag gta atc ggc atc atc ggt tac tct ggc gcc ggc aag tcc 307
Pro Gly Glu Val Ile Gly Ile Ile Gly Tyr Ser Gly Ala Gly Lys Ser
55 60 65
act ctt gtc cgc ctc atc aat ggc ctt gac tcc ccc acg agc ggt tcg 355
Thr Leu Val Arg Leu Ile Asn Gly Leu Asp Ser Pro Thr Ser Gly Ser
70 75 80 85
ttg ctg ctc aac ggc acc gac atc gtc gga atg ccc gag tct aag ctg 403
Leu Leu Leu Asn Gly Thr Asp Ile Val Gly Met Pro Glu Ser Lys Leu
90 95 100
cgt aaa ctg cgc agt aat atc ggc atg att ttc cag cag ttc aac ctg 451
Arg Lys Leu Arg Ser Asn Ile Gly Met Ile Phe Gln Gln Phe Asn Leu
105 110 115
ttc cag tcg cgt act gcg gct gga aat gtg gag tac ccg ctg gaa gtt 499
Phe Gln Ser Arg Thr Ala Ala Gly Asn Val Glu Tyr Pro Leu Glu Val
120 125 130
gcc aag atg gac aag gca gct cgt aaa gct cgc gtg caa gaa atg ctc 547
Ala Lys Met Asp Lys Ala Ala Arg Lys Ala Arg Val Gln Glu Met Leu
135 140 145
gag ttc gtc ggc ctg ggc gac aaa ggc aaa aac tac ccc gag cag ctg 595
Glu Phe Val Gly Leu Gly Asp Lys Gly Lys Asn Tyr Pro Glu Gln Leu
150 155 160 165
tcg ggc ggc cag aag cag cgc gtc ggc att gcc cgt gca ctg gcc acc 643
Ser Gly Gly Gln Lys Gln Arg Val Gly Ile Ala Arg Ala Leu Ala Thr
170 175 180
aat cca acg ctt ttg ctt gcc gac gaa gcc acc tcc gct ttg gac cca 691
Asn Pro Thr Leu Leu Leu Ala Asp Glu Ala Thr Ser Ala Leu Asp Pro
185 190 195
gaa acc acc cat gaa gtt ctg gag ctg ctg cgc aag gta aac cgc gaa 739
Glu Thr Thr His Glu Val Leu Glu Leu Leu Arg Lys Val Asn Arg Glu
200 205 210
ctg ggc atc acc atc gtt gtg atc acc cac gaa atg gaa gtt gtg cgt 787
Leu Gly Ile Thr Ile Val Val Ile Thr His Glu Met Glu Val Val Arg
215 220 225
tcc atc gca gac aag gtt gct gtg atg gaa tcc ggc aaa gtt gtg gaa 835
Ser Ile Ala Asp Lys Val Ala Val Met Glu Ser Gly Lys Val Val Glu
230 235 240 245
tac ggc agc gtc tac gag gtg ttc tcc aat cca caa aca cag gtt gct 883
Tyr Gly Ser Val Tyr Glu Val Phe Ser Asn Pro Gln Thr Gln Val Ala
250 255 260
caa aag ttc gtg gcc acc gcg ctg cgt aac acc cca gac caa gtg gaa 931
Gln Lys Phe Val Ala Thr Ala Leu Arg Asn Thr Pro Asp Gln Val Glu
265 270 275
tcg gaa gat ctg ctt agc cat gag gga cgt ctg ttc acc att gat ctg 979
Ser Glu Asp Leu Leu Ser His Glu Gly Arg Leu Phe Thr Ile Asp Leu
280 285 290
act gaa acg tcc ggc ttc ttt gca gca acc gct cgt gct gcc gaa caa 1027
Thr Glu Thr Ser Gly Phe Phe Ala Ala Thr Ala Arg Ala Ala Glu Gln
295 300 305
ggt gct ttt gtc aac atc gtt cac ggt ggc gtg acc acc ttg caa cgc 1075
Gly Ala Phe Val Asn Ile Val His Gly Gly Val Thr Thr Leu Gln Arg
310 315 320 325
caa tca ttt ggc aaa atg act gtt cga ctc acc ggc aac acc gct gcg 1123
Gln Ser Phe Gly Lys Met Thr Val Arg Leu Thr Gly Asn Thr Ala Ala
330 335 340
att gaa gag ttc tat caa acc ttg acc aag acc acg acc atc aag gag 1171
Ile Glu Glu Phe Tyr Gln Thr Leu Thr Lys Thr Thr Thr Ile Lys Glu
345 350 355
atc acc cga tgaacgagat gatcctcgca gct 1203
Ile Thr Arg
360
<210> 364
<211> 360
<212> PRT
<213> Corynebacterium glutamicum
<400> 364
Val Ser His Thr Ala Ser Thr Pro Thr Pro Glu Glu Tyr Ser Ala Gln
1 5 10 15
Gln Pro Ser Thr Gln Gly Thr Arg Val Glu Phe Arg Gly Ile Thr Lys
20 25 30
Val Phe Ser Asn Asn Lys Ser Ala Lys Thr Thr Ala Leu Asp Asn Val
35 40 45
Thr Leu Thr Val Glu Pro Gly Glu Val Ile Gly Ile Ile Gly Tyr Ser
50 55 60
Gly Ala Gly Lys Ser Thr Leu Val Arg Leu Ile Asn Gly Leu Asp Ser
65 70 75 80
Pro Thr Ser Gly Ser Leu Leu Leu Asn Gly Thr Asp Ile Val Gly Met
85 90 95
Pro Glu Ser Lys Leu Arg Lys Leu Arg Ser Asn Ile Gly Met Ile Phe
100 105 110
Gln Gln Phe Asn Leu Phe Gln Ser Arg Thr Ala Ala Gly Asn Val Glu
115 120 125
Tyr Pro Leu Glu Val Ala Lys Met Asp Lys Ala Ala Arg Lys Ala Arg
130 135 140
Val Gln Glu Met Leu Glu Phe Val Gly Leu Gly Asp Lys Gly Lys Asn
145 150 155 160
Tyr Pro Glu Gln Leu Ser Gly Gly Gln Lys Gln Arg Val Gly Ile Ala
165 170 175
Arg Ala Leu Ala Thr Asn Pro Thr Leu Leu Leu Ala Asp Glu Ala Thr
180 185 190
Ser Ala Leu Asp Pro Glu Thr Thr His Glu Val Leu Glu Leu Leu Arg
195 200 205
Lys Val Asn Arg Glu Leu Gly Ile Thr Ile Val Val Ile Thr His Glu
210 215 220
Met Glu Val Val Arg Ser Ile Ala Asp Lys Val Ala Val Met Glu Ser
225 230 235 240
Gly Lys Val Val Glu Tyr Gly Ser Val Tyr Glu Val Phe Ser Asn Pro
245 250 255
Gln Thr Gln Val Ala Gln Lys Phe Val Ala Thr Ala Leu Arg Asn Thr
260 265 270
Pro Asp Gln Val Glu Ser Glu Asp Leu Leu Ser His Glu Gly Arg Leu
275 280 285
Phe Thr Ile Asp Leu Thr Glu Thr Ser Gly Phe Phe Ala Ala Thr Ala
290 295 300
Arg Ala Ala Glu Gln Gly Ala Phe Val Asn Ile Val His Gly Gly Val
305 310 315 320
Thr Thr Leu Gln Arg Gln Ser Phe Gly Lys Met Thr Val Arg Leu Thr
325 330 335
Gly Asn Thr Ala Ala Ile Glu Glu Phe Tyr Gln Thr Leu Thr Lys Thr
340 345 350
Thr Thr Ile Lys Glu Ile Thr Arg
355 360
<210> 365
<211> 798
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(775)
<223> RXN00411
<400> 365
catttggcaa aatgactgtt cgactcaccg gcaacaccgc tgcgattgaa gagttctatc 60
aaaccttgac caagaccacg accatcaagg agatcacccg atg aac gag atg atc 115
Met Asn Glu Met Ile
1 5
ctc gca gct gac tgg aac cgg cta gga ccc acc ttc caa aca gcc atc 163
Leu Ala Ala Asp Trp Asn Arg Leu Gly Pro Thr Phe Gln Thr Ala Ile
10 15 20
att gac acc ctg ttg atg gtc atc atc acc atg gtg gtg gct ggc tta 211
Ile Asp Thr Leu Leu Met Val Ile Ile Thr Met Val Val Ala Gly Leu
25 30 35
ctg ggt ctt gtc gtc ggc ctg ctg ctt tac acc acc cgc gct ggt gga 259
Leu Gly Leu Val Val Gly Leu Leu Leu Tyr Thr Thr Arg Ala Gly Gly
40 45 50
atc ttg aag aac aag gtc atc tac acc att ttg aat gtg ctg gtg aac 307
Ile Leu Lys Asn Lys Val Ile Tyr Thr Ile Leu Asn Val Leu Val Asn
55 60 65
ttt gtt cga ccc atc cca ttc att att ttg atc gcc gcc atc aag cca 355
Phe Val Arg Pro Ile Pro Phe Ile Ile Leu Ile Ala Ala Ile Lys Pro
70 75 80 85
cta acg gtc gcc gtc atg ggc acc tcc atc ggc cga gat gcc ggc atc 403
Leu Thr Val Ala Val Met Gly Thr Ser Ile Gly Arg Asp Ala Gly Ile
90 95 100
ttc gtc atg gtt gtc gca gcg att ttc tct gtg gct cga atc gtg gag 451
Phe Val Met Val Val Ala Ala Ile Phe Ser Val Ala Arg Ile Val Glu
105 110 115
caa aac ttg gtc tcc att gat cct ggt gtc atc gag gca gct cgc tcc 499
Gln Asn Leu Val Ser Ile Asp Pro Gly Val Ile Glu Ala Ala Arg Ser
120 125 130
atg ggt gcg tcc ccg atg cgc atc atc gcc acc gtg atc att cca gaa 547
Met Gly Ala Ser Pro Met Arg Ile Ile Ala Thr Val Ile Ile Pro Glu
135 140 145
gca ctt gga cca ttg gtt ctg ggt tac acc ttc ctg ttc atc gcg atc 595
Ala Leu Gly Pro Leu Val Leu Gly Tyr Thr Phe Leu Phe Ile Ala Ile
150 155 160 165
gtc gat atg tcc gca atg gtc ggc tac atc ggt ggc ggt ggt ctt ggt 643
Val Asp Met Ser Ala Met Val Gly Tyr Ile Gly Gly Gly Gly Leu Gly
170 175 180
gac ttc gcc att gtt tac ggc tac cgc gcc ttc gac aac gaa gtt atg 691
Asp Phe Ala Ile Val Tyr Gly Tyr Arg Ala Phe Asp Asn Glu Val Met
185 190 195
tac gtt gcc gtc ctg gtt atc gtc atc atc gtg cag gca gcc cag ctt 739
Tyr Val Ala Val Leu Val Ile Val Ile Ile Val Gln Ala Ala Gln Leu
200 205 210
ctg ggc aat tgg ctg tcc aag aag atc atg cgc cgc taaacctctt 785
Leu Gly Asn Trp Leu Ser Lys Lys Ile Met Arg Arg
215 220 225
gcatagaaaa acc 798
<210> 366
<211> 225
<212> PRT
<213> Corynebacterium glutamicum
<400> 366
Met Asn Glu Met Ile Leu Ala Ala Asp Trp Asn Arg Leu Gly Pro Thr
1 5 10 15
Phe Gln Thr Ala Ile Ile Asp Thr Leu Leu Met Val Ile Ile Thr Met
20 25 30
Val Val Ala Gly Leu Leu Gly Leu Val Val Gly Leu Leu Leu Tyr Thr
35 40 45
Thr Arg Ala Gly Gly Ile Leu Lys Asn Lys Val Ile Tyr Thr Ile Leu
50 55 60
Asn Val Leu Val Asn Phe Val Arg Pro Ile Pro Phe Ile Ile Leu Ile
65 70 75 80
Ala Ala Ile Lys Pro Leu Thr Val Ala Val Met Gly Thr Ser Ile Gly
85 90 95
Arg Asp Ala Gly Ile Phe Val Met Val Val Ala Ala Ile Phe Ser Val
100 105 110
Ala Arg Ile Val Glu Gln Asn Leu Val Ser Ile Asp Pro Gly Val Ile
115 120 125
Glu Ala Ala Arg Ser Met Gly Ala Ser Pro Met Arg Ile Ile Ala Thr
130 135 140
Val Ile Ile Pro Glu Ala Leu Gly Pro Leu Val Leu Gly Tyr Thr Phe
145 150 155 160
Leu Phe Ile Ala Ile Val Asp Met Ser Ala Met Val Gly Tyr Ile Gly
165 170 175
Gly Gly Gly Leu Gly Asp Phe Ala Ile Val Tyr Gly Tyr Arg Ala Phe
180 185 190
Asp Asn Glu Val Met Tyr Val Ala Val Leu Val Ile Val Ile Ile Val
195 200 205
Gln Ala Ala Gln Leu Leu Gly Asn Trp Leu Ser Lys Lys Ile Met Arg
210 215 220
Arg
225
<210> 367
<211> 852
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(829)
<223> RXN02614
<400> 367
tcattgtata cgccaccctc ggtctgctgt ctgaagcgct gatcagagct tgggaacgtc 60
acaccttccg ctaccgaaac gcataagaaa gttgctcgcc atg act gcc aca ttg 115
Met Thr Ala Thr Leu
1 5
tca ctc aaa ccc gca gcc act gtc cgt gga ttg cgc aaa tca tac gga 163
Ser Leu Lys Pro Ala Ala Thr Val Arg Gly Leu Arg Lys Ser Tyr Gly
10 15 20
act aaa gaa gtc ctc caa gga atc gac ctc acc atc aac tgc ggc gaa 211
Thr Lys Glu Val Leu Gln Gly Ile Asp Leu Thr Ile Asn Cys Gly Glu
25 30 35
gta acc gcg ctg atc gga cgc tca ggt tca gga aaa tcc acc atc ctg 259
Val Thr Ala Leu Ile Gly Arg Ser Gly Ser Gly Lys Ser Thr Ile Leu
40 45 50
cgc gtg ttg gcg ggc cta tct aaa gag cat tcc ggc tct gta gaa att 307
Arg Val Leu Ala Gly Leu Ser Lys Glu His Ser Gly Ser Val Glu Ile
55 60 65
tcc gga aac ccg gcc gtt gcc ttc caa gag cct cgc ctg ttg ccg tgg 355
Ser Gly Asn Pro Ala Val Ala Phe Gln Glu Pro Arg Leu Leu Pro Trp
70 75 80 85
aaa acg gtg ctc gat aat gtg acc ttt ggc ctc aac cgc act gat att 403
Lys Thr Val Leu Asp Asn Val Thr Phe Gly Leu Asn Arg Thr Asp Ile
90 95 100
tcc tgg tca gaa gca caa gaa cgc gcc tcg gca ctg ctt gca gaa gtc 451
Ser Trp Ser Glu Ala Gln Glu Arg Ala Ser Ala Leu Leu Ala Glu Val
105 110 115
aaa ctt ccc gac tcc gac gcc gcc tgg ccc ctc acg ctc tcc ggc ggc 499
Lys Leu Pro Asp Ser Asp Ala Ala Trp Pro Leu Thr Leu Ser Gly Gly
120 125 130
caa gcc cag cgc gtc tcc ctt gcg cga gcg ctc atc tcc gag cca gag 547
Gln Ala Gln Arg Val Ser Leu Ala Arg Ala Leu Ile Ser Glu Pro Glu
135 140 145
ctt ttg ctt ctc gac gaa ccc ttc ggc gcc ctc gat gct ctg aca aga 595
Leu Leu Leu Leu Asp Glu Pro Phe Gly Ala Leu Asp Ala Leu Thr Arg
150 155 160 165
ctg aca gcc caa gac ctg ctg ctc aaa acc gtg aac acc cga aac ttg 643
Leu Thr Ala Gln Asp Leu Leu Leu Lys Thr Val Asn Thr Arg Asn Leu
170 175 180
gga gtt ctg ctg gtc acc cat gat gtt tcc gag gcc atc gcc ctg gcc 691
Gly Val Leu Leu Val Thr His Asp Val Ser Glu Ala Ile Ala Leu Ala
185 190 195
gac cac gtc ctt ctt ctt gac gac ggc gcc atc aca cac agt ttg act 739
Asp His Val Leu Leu Leu Asp Asp Gly Ala Ile Thr His Ser Leu Thr
200 205 210
gta gat atc ccc ggc gat cgc cgc acc cac ccc tcc ttt gcc tcc tac 787
Val Asp Ile Pro Gly Asp Arg Arg Thr His Pro Ser Phe Ala Ser Tyr
215 220 225
acc gct caa ctc ctt gag tgg ctc gaa atc acc aca cct gcc 829
Thr Ala Gln Leu Leu Glu Trp Leu Glu Ile Thr Thr Pro Ala
230 235 240
tagaaagaaa tcatgaaatt taa 852
<210> 368
<211> 243
<212> PRT
<213> Corynebacterium glutamicum
<400> 368
Met Thr Ala Thr Leu Ser Leu Lys Pro Ala Ala Thr Val Arg Gly Leu
1 5 10 15
Arg Lys Ser Tyr Gly Thr Lys Glu Val Leu Gln Gly Ile Asp Leu Thr
20 25 30
Ile Asn Cys Gly Glu Val Thr Ala Leu Ile Gly Arg Ser Gly Ser Gly
35 40 45
Lys Ser Thr Ile Leu Arg Val Leu Ala Gly Leu Ser Lys Glu His Ser
50 55 60
Gly Ser Val Glu Ile Ser Gly Asn Pro Ala Val Ala Phe Gln Glu Pro
65 70 75 80
Arg Leu Leu Pro Trp Lys Thr Val Leu Asp Asn Val Thr Phe Gly Leu
85 90 95
Asn Arg Thr Asp Ile Ser Trp Ser Glu Ala Gln Glu Arg Ala Ser Ala
100 105 110
Leu Leu Ala Glu Val Lys Leu Pro Asp Ser Asp Ala Ala Trp Pro Leu
115 120 125
Thr Leu Ser Gly Gly Gln Ala Gln Arg Val Ser Leu Ala Arg Ala Leu
130 135 140
Ile Ser Glu Pro Glu Leu Leu Leu Leu Asp Glu Pro Phe Gly Ala Leu
145 150 155 160
Asp Ala Leu Thr Arg Leu Thr Ala Gln Asp Leu Leu Leu Lys Thr Val
165 170 175
Asn Thr Arg Asn Leu Gly Val Leu Leu Val Thr His Asp Val Ser Glu
180 185 190
Ala Ile Ala Leu Ala Asp His Val Leu Leu Leu Asp Asp Gly Ala Ile
195 200 205
Thr His Ser Leu Thr Val Asp Ile Pro Gly Asp Arg Arg Thr His Pro
210 215 220
Ser Phe Ala Ser Tyr Thr Ala Gln Leu Leu Glu Trp Leu Glu Ile Thr
225 230 235 240
Thr Pro Ala
<210> 369
<211> 1080
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1057)
<223> RXN02613
<400> 369
agatatcccc ggcgatcgcc gcacccaccc ctcctttgcc tcctacaccg ctcaactcct 60
tgagtggctc gaaatcacca cacctgccta gaaagaaatc atg aaa ttt aag aaa 115
Met Lys Phe Lys Lys
1 5
atc gcc ctc gtt ctc gcc ttc ggt cta ggc ctt gca tcc tgc tca tca 163
Ile Ala Leu Val Leu Ala Phe Gly Leu Gly Leu Ala Ser Cys Ser Ser
10 15 20
gct tct ggc gat ccc gcc acc aac gcc gat gga tcc atc gat ctg agc 211
Ala Ser Gly Asp Pro Ala Thr Asn Ala Asp Gly Ser Ile Asp Leu Ser
25 30 35
aaa gta acc ctt aac atc ggt gat caa atc gcc gga aca gaa caa gtg 259
Lys Val Thr Leu Asn Ile Gly Asp Gln Ile Ala Gly Thr Glu Gln Val
40 45 50
ctc caa gct tca ggg gag cta gat gat gtc cct tat aaa atc gaa tgg 307
Leu Gln Ala Ser Gly Glu Leu Asp Asp Val Pro Tyr Lys Ile Glu Trp
55 60 65
tca tca ttt acc tct gga cca ccc caa atc gaa gca tta aac gca ggt 355
Ser Ser Phe Thr Ser Gly Pro Pro Gln Ile Glu Ala Leu Asn Ala Gly
70 75 80 85
caa att gat ttc gcg atc acc gga aac acc cca ccg atc atc ggc ggc 403
Gln Ile Asp Phe Ala Ile Thr Gly Asn Thr Pro Pro Ile Ile Gly Gly
90 95 100
ccc acc aac acc aaa gtg gtc tcc gcc tac aac aac gat gct tta ggt 451
Pro Thr Asn Thr Lys Val Val Ser Ala Tyr Asn Asn Asp Ala Leu Gly
105 110 115
gat gtc atc ttg gtc gcc ccg gat tct tca ata acc tcg gtg gct gac 499
Asp Val Ile Leu Val Ala Pro Asp Ser Ser Ile Thr Ser Val Ala Asp
120 125 130
ctt gct gga aag aaa gtg gct gtc gcc cgc gga tcc agc gcc cac gga 547
Leu Ala Gly Lys Lys Val Ala Val Ala Arg Gly Ser Ser Ala His Gly
135 140 145
cac ctc atc caa caa cta gaa aaa gca ggc gtg agc gtt gac gac gta 595
His Leu Ile Gln Gln Leu Glu Lys Ala Gly Val Ser Val Asp Asp Val
150 155 160 165
gaa atc aac ctc ctc caa ccc tcc gac gcc aaa gcc gct ttc caa aac 643
Glu Ile Asn Leu Leu Gln Pro Ser Asp Ala Lys Ala Ala Phe Gln Asn
170 175 180
ggc cag gta gat gcg tgg gca gtg tgg gat ccc tac agc tca cag gcg 691
Gly Gln Val Asp Ala Trp Ala Val Trp Asp Pro Tyr Ser Ser Gln Ala
185 190 195
gaa ctg gaa gga gct caa gtt ttg gtc agg gga gcg gga ctg gtc agt 739
Glu Leu Glu Gly Ala Gln Val Leu Val Arg Gly Ala Gly Leu Val Ser
200 205 210
ggg cat gga ttt ggt gtc gca agt gat gaa gcg ctc gat gac ccc gca 787
Gly His Gly Phe Gly Val Ala Ser Asp Glu Ala Leu Asp Asp Pro Ala
215 220 225
aag gaa gcc gcc ttg gca gat ttc ctc gat cgc gtg gcc gac tct tat 835
Lys Glu Ala Ala Leu Ala Asp Phe Leu Asp Arg Val Ala Asp Ser Tyr
230 235 240 245
gaa tgg gct gaa gac aac acc gat gaa tgg gcg acg att ttc agc caa 883
Glu Trp Ala Glu Asp Asn Thr Asp Glu Trp Ala Thr Ile Phe Ser Gln
250 255 260
gaa tcc ggc ttt gat ccg gag gcc tct caa ctg aac acc cgc agc ctg 931
Glu Ser Gly Phe Asp Pro Glu Ala Ser Gln Leu Asn Thr Arg Ser Leu
265 270 275
cgc cat cag gtg ccg ctc gac gag tcc gtc aac acc tat cag aac gcg 979
Arg His Gln Val Pro Leu Asp Glu Ser Val Asn Thr Tyr Gln Asn Ala
280 285 290
ctt atc gac gct ttc gtc tcc gcg ggt ctc gtt gag gac ttt aat ttc 1027
Leu Ile Asp Ala Phe Val Ser Ala Gly Leu Val Glu Asp Phe Asn Phe
295 300 305
gag gac acc gta gac acc cga ttt gag ggc taagtatgtc tgagtatggc 1077
Glu Asp Thr Val Asp Thr Arg Phe Glu Gly
310 315
aaa 1080
<210> 370
<211> 319
<212> PRT
<213> Corynebacterium glutamicum
<400> 370
Met Lys Phe Lys Lys Ile Ala Leu Val Leu Ala Phe Gly Leu Gly Leu
1 5 10 15
Ala Ser Cys Ser Ser Ala Ser Gly Asp Pro Ala Thr Asn Ala Asp Gly
20 25 30
Ser Ile Asp Leu Ser Lys Val Thr Leu Asn Ile Gly Asp Gln Ile Ala
35 40 45
Gly Thr Glu Gln Val Leu Gln Ala Ser Gly Glu Leu Asp Asp Val Pro
50 55 60
Tyr Lys Ile Glu Trp Ser Ser Phe Thr Ser Gly Pro Pro Gln Ile Glu
65 70 75 80
Ala Leu Asn Ala Gly Gln Ile Asp Phe Ala Ile Thr Gly Asn Thr Pro
85 90 95
Pro Ile Ile Gly Gly Pro Thr Asn Thr Lys Val Val Ser Ala Tyr Asn
100 105 110
Asn Asp Ala Leu Gly Asp Val Ile Leu Val Ala Pro Asp Ser Ser Ile
115 120 125
Thr Ser Val Ala Asp Leu Ala Gly Lys Lys Val Ala Val Ala Arg Gly
130 135 140
Ser Ser Ala His Gly His Leu Ile Gln Gln Leu Glu Lys Ala Gly Val
145 150 155 160
Ser Val Asp Asp Val Glu Ile Asn Leu Leu Gln Pro Ser Asp Ala Lys
165 170 175
Ala Ala Phe Gln Asn Gly Gln Val Asp Ala Trp Ala Val Trp Asp Pro
180 185 190
Tyr Ser Ser Gln Ala Glu Leu Glu Gly Ala Gln Val Leu Val Arg Gly
195 200 205
Ala Gly Leu Val Ser Gly His Gly Phe Gly Val Ala Ser Asp Glu Ala
210 215 220
Leu Asp Asp Pro Ala Lys Glu Ala Ala Leu Ala Asp Phe Leu Asp Arg
225 230 235 240
Val Ala Asp Ser Tyr Glu Trp Ala Glu Asp Asn Thr Asp Glu Trp Ala
245 250 255
Thr Ile Phe Ser Gln Glu Ser Gly Phe Asp Pro Glu Ala Ser Gln Leu
260 265 270
Asn Thr Arg Ser Leu Arg His Gln Val Pro Leu Asp Glu Ser Val Asn
275 280 285
Thr Tyr Gln Asn Ala Leu Ile Asp Ala Phe Val Ser Ala Gly Leu Val
290 295 300
Glu Asp Phe Asn Phe Glu Asp Thr Val Asp Thr Arg Phe Glu Gly
305 310 315
<210> 371
<211> 1698
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1675)
<223> RXN00368
<400> 371
ttcttccaaa acgcaatgaa ctagttttcc tatgcagtta tctccttcaa atacgtcgac 60
gcagcgcttt cacatctctg cgttgacgtc tttgtctttc atg cgt ctg ggt gtg 115
Met Arg Leu Gly Val
1 5
tgg ctg att gtc gcg ggg ttg ttt atc act ccg ttg gcg ctg gtg gtg 163
Trp Leu Ile Val Ala Gly Leu Phe Ile Thr Pro Leu Ala Leu Val Val
10 15 20
ggc ttg gcg ttg gga ggc aat cag ttt cct gct ctg tgg gat tcc gga 211
Gly Leu Ala Leu Gly Gly Asn Gln Phe Pro Ala Leu Trp Asp Ser Gly
25 30 35
ttg ggc aaa gcc cta tgg aat tcc gcc tat aca aca gtg ctt tct gcg 259
Leu Gly Lys Ala Leu Trp Asn Ser Ala Tyr Thr Thr Val Leu Ser Ala
40 45 50
gtg ggc gcg acc att atc ggc acg atc atg gct ctc acg ctg gac cga 307
Val Gly Ala Thr Ile Ile Gly Thr Ile Met Ala Leu Thr Leu Asp Arg
55 60 65
act gat gtt ttc ggg cgc acc gcg ttg cgg tta ttt ttg tta tcc ccg 355
Thr Asp Val Phe Gly Arg Thr Ala Leu Arg Leu Phe Leu Leu Ser Pro
70 75 80 85
ctg ttg atc cct ccg ttt att ggg gct att gcg tgg ttg cag ctg ttc 403
Leu Leu Ile Pro Pro Phe Ile Gly Ala Ile Ala Trp Leu Gln Leu Phe
90 95 100
ggg aag aac cag ggc atc aac cgg ttt ttc ggc acg gaa gtg tgg gat 451
Gly Lys Asn Gln Gly Ile Asn Arg Phe Phe Gly Thr Glu Val Trp Asp
105 110 115
att tac ggc gct gat ggt gtg aca ttt ttg ttg att gtg cac tcc tat 499
Ile Tyr Gly Ala Asp Gly Val Thr Phe Leu Leu Ile Val His Ser Tyr
120 125 130
ccc act gtg tac atc att gtt tcg gca gct ctg agg caa ctt cct agt 547
Pro Thr Val Tyr Ile Ile Val Ser Ala Ala Leu Arg Gln Leu Pro Ser
135 140 145
gat ttg gag caa gct gca cgg atc gcg ggg gcg gat act ttt acg gtg 595
Asp Leu Glu Gln Ala Ala Arg Ile Ala Gly Ala Asp Thr Phe Thr Val
150 155 160 165
ttg cgc acc atc aca ctc cca ctg ctc aaa cct gca ttg ttg tcg gcg 643
Leu Arg Thr Ile Thr Leu Pro Leu Leu Lys Pro Ala Leu Leu Ser Ala
170 175 180
ttt act ctt acc aca gtg gcg aac ctc gcc gac ttt ggc att cca gct 691
Phe Thr Leu Thr Thr Val Ala Asn Leu Ala Asp Phe Gly Ile Pro Ala
185 190 195
ctg ttg gga tcg cca gcg cgt ttt gaa acc tta gcc acc atg att tat 739
Leu Leu Gly Ser Pro Ala Arg Phe Glu Thr Leu Ala Thr Met Ile Tyr
200 205 210
cgc ttc atg gaa tcc ggc acc gtg agc aat cca ttg cag gtg gta tcc 787
Arg Phe Met Glu Ser Gly Thr Val Ser Asn Pro Leu Gln Val Val Ser
215 220 225
acc att ggc atc gtg ttg ttg ttc ctg gga atc gca gca gta acc gcg 835
Thr Ile Gly Ile Val Leu Leu Phe Leu Gly Ile Ala Ala Val Thr Ala
230 235 240 245
gat tat ctg gtg tct ttg tac gcg gca tca aag ttg caa gac gca gga 883
Asp Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys Leu Gln Asp Ala Gly
250 255 260
aca ccg cat cgc ttt act ctc aac aaa tca cga atc cca gtc agc gtg 931
Thr Pro His Arg Phe Thr Leu Asn Lys Ser Arg Ile Pro Val Ser Val
265 270 275
atc acg tgg atc atc gcg ttg atc atc acc gcc gcc ccg ctg ctg ggt 979
Ile Thr Trp Ile Ile Ala Leu Ile Ile Thr Ala Ala Pro Leu Leu Gly
280 285 290
ctg gca tac aga gca tta ctg cct gcc cca ggt gtg ccg ttc aac cta 1027
Leu Ala Tyr Arg Ala Leu Leu Pro Ala Pro Gly Val Pro Phe Asn Leu
295 300 305
gac aac atc acg ctc aac aac ttt gaa gca gca ctg agc aat cca cga 1075
Asp Asn Ile Thr Leu Asn Asn Phe Glu Ala Ala Leu Ser Asn Pro Arg
310 315 320 325
gta atc gaa gga ttc agc aac tcc ctc atg tta tcc ctg ggt gca gcc 1123
Val Ile Glu Gly Phe Ser Asn Ser Leu Met Leu Ser Leu Gly Ala Ala
330 335 340
cta atc tgt ggg gtg ctg gga tgg ctg atc gga gtg ctc atc acc cga 1171
Leu Ile Cys Gly Val Leu Gly Trp Leu Ile Gly Val Leu Ile Thr Arg
345 350 355
acc cag cat ttc gcc aac gta ccg ttg aca ctc act gtg ctg ctt ccc 1219
Thr Gln His Phe Ala Asn Val Pro Leu Thr Leu Thr Val Leu Leu Pro
360 365 370
acc gca ctg ccg ggc atg atc atc ggc gtc ggc tgg ctc att ttg ggc 1267
Thr Ala Leu Pro Gly Met Ile Ile Gly Val Gly Trp Leu Ile Leu Gly
375 380 385
aga tac acc gga att tac aac aca cct tgg gtg att ttg ggt gca tat 1315
Arg Tyr Thr Gly Ile Tyr Asn Thr Pro Trp Val Ile Leu Gly Ala Tyr
390 395 400 405
gtg tgt gct ttt acc gcg ctg gtt gtc caa gct gta cgc gga cca ctc 1363
Val Cys Ala Phe Thr Ala Leu Val Val Gln Ala Val Arg Gly Pro Leu
410 415 420
agt caa gca ccc gaa gca atc gaa gaa gcc gca cga atc agc ggc gca 1411
Ser Gln Ala Pro Glu Ala Ile Glu Glu Ala Ala Arg Ile Ser Gly Ala
425 430 435
ggc aga tta cga tcc atc atg gac acc acc gga gcg atg gca att ccc 1459
Gly Arg Leu Arg Ser Ile Met Asp Thr Thr Gly Ala Met Ala Ile Pro
440 445 450
gca gct ttc gcc ggc gca gtg ctg gtt gcg gta act gcg gtt cga gag 1507
Ala Ala Phe Ala Gly Ala Val Leu Val Ala Val Thr Ala Val Arg Glu
455 460 465
tta acc gtg tcc att ttg ctc atc gcg ccg ggc acc acc acc ctg ggt 1555
Leu Thr Val Ser Ile Leu Leu Ile Ala Pro Gly Thr Thr Thr Leu Gly
470 475 480 485
gtg cag gtg ttc aat ttg cag cag gcg gga aat tac aat cag gca tcg 1603
Val Gln Val Phe Asn Leu Gln Gln Ala Gly Asn Tyr Asn Gln Ala Ser
490 495 500
gcg ttg tcg ttg atg ttt gcg att atc ggt atc gtg gcg ctc gcg ttg 1651
Ala Leu Ser Leu Met Phe Ala Ile Ile Gly Ile Val Ala Leu Ala Leu
505 510 515
acg gtg cgc agc cag aag gag ttt taggtgtcat cgatcaaatt gcg 1698
Thr Val Arg Ser Gln Lys Glu Phe
520 525
<210> 372
<211> 525
<212> PRT
<213> Corynebacterium glutamicum
<400> 372
Met Arg Leu Gly Val Trp Leu Ile Val Ala Gly Leu Phe Ile Thr Pro
1 5 10 15
Leu Ala Leu Val Val Gly Leu Ala Leu Gly Gly Asn Gln Phe Pro Ala
20 25 30
Leu Trp Asp Ser Gly Leu Gly Lys Ala Leu Trp Asn Ser Ala Tyr Thr
35 40 45
Thr Val Leu Ser Ala Val Gly Ala Thr Ile Ile Gly Thr Ile Met Ala
50 55 60
Leu Thr Leu Asp Arg Thr Asp Val Phe Gly Arg Thr Ala Leu Arg Leu
65 70 75 80
Phe Leu Leu Ser Pro Leu Leu Ile Pro Pro Phe Ile Gly Ala Ile Ala
85 90 95
Trp Leu Gln Leu Phe Gly Lys Asn Gln Gly Ile Asn Arg Phe Phe Gly
100 105 110
Thr Glu Val Trp Asp Ile Tyr Gly Ala Asp Gly Val Thr Phe Leu Leu
115 120 125
Ile Val His Ser Tyr Pro Thr Val Tyr Ile Ile Val Ser Ala Ala Leu
130 135 140
Arg Gln Leu Pro Ser Asp Leu Glu Gln Ala Ala Arg Ile Ala Gly Ala
145 150 155 160
Asp Thr Phe Thr Val Leu Arg Thr Ile Thr Leu Pro Leu Leu Lys Pro
165 170 175
Ala Leu Leu Ser Ala Phe Thr Leu Thr Thr Val Ala Asn Leu Ala Asp
180 185 190
Phe Gly Ile Pro Ala Leu Leu Gly Ser Pro Ala Arg Phe Glu Thr Leu
195 200 205
Ala Thr Met Ile Tyr Arg Phe Met Glu Ser Gly Thr Val Ser Asn Pro
210 215 220
Leu Gln Val Val Ser Thr Ile Gly Ile Val Leu Leu Phe Leu Gly Ile
225 230 235 240
Ala Ala Val Thr Ala Asp Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys
245 250 255
Leu Gln Asp Ala Gly Thr Pro His Arg Phe Thr Leu Asn Lys Ser Arg
260 265 270
Ile Pro Val Ser Val Ile Thr Trp Ile Ile Ala Leu Ile Ile Thr Ala
275 280 285
Ala Pro Leu Leu Gly Leu Ala Tyr Arg Ala Leu Leu Pro Ala Pro Gly
290 295 300
Val Pro Phe Asn Leu Asp Asn Ile Thr Leu Asn Asn Phe Glu Ala Ala
305 310 315 320
Leu Ser Asn Pro Arg Val Ile Glu Gly Phe Ser Asn Ser Leu Met Leu
325 330 335
Ser Leu Gly Ala Ala Leu Ile Cys Gly Val Leu Gly Trp Leu Ile Gly
340 345 350
Val Leu Ile Thr Arg Thr Gln His Phe Ala Asn Val Pro Leu Thr Leu
355 360 365
Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met Ile Ile Gly Val Gly
370 375 380
Trp Leu Ile Leu Gly Arg Tyr Thr Gly Ile Tyr Asn Thr Pro Trp Val
385 390 395 400
Ile Leu Gly Ala Tyr Val Cys Ala Phe Thr Ala Leu Val Val Gln Ala
405 410 415
Val Arg Gly Pro Leu Ser Gln Ala Pro Glu Ala Ile Glu Glu Ala Ala
420 425 430
Arg Ile Ser Gly Ala Gly Arg Leu Arg Ser Ile Met Asp Thr Thr Gly
435 440 445
Ala Met Ala Ile Pro Ala Ala Phe Ala Gly Ala Val Leu Val Ala Val
450 455 460
Thr Ala Val Arg Glu Leu Thr Val Ser Ile Leu Leu Ile Ala Pro Gly
465 470 475 480
Thr Thr Thr Leu Gly Val Gln Val Phe Asn Leu Gln Gln Ala Gly Asn
485 490 495
Tyr Asn Gln Ala Ser Ala Leu Ser Leu Met Phe Ala Ile Ile Gly Ile
500 505 510
Val Ala Leu Ala Leu Thr Val Arg Ser Gln Lys Glu Phe
515 520 525
<210> 373
<211> 602
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(579)
<223> FRXA00368
<400> 373
tcc ctc atg tta tcc ctg ggt gca gcc cta atc tgt ggg gtg ctg gga 48
Ser Leu Met Leu Ser Leu Gly Ala Ala Leu Ile Cys Gly Val Leu Gly
1 5 10 15
tgg ctg atc gga gtg ctc atc acc cga acc cag cat ttc gcc aac gta 96
Trp Leu Ile Gly Val Leu Ile Thr Arg Thr Gln His Phe Ala Asn Val
20 25 30
ccg ttg aca ctc act gtg ctg ctt ccc acc gca ctg ccg ggc atg atc 144
Pro Leu Thr Leu Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met Ile
35 40 45
atc ggc gtc ggc tgg ctc att ttg ggc aga tac acc gga att tac aac 192
Ile Gly Val Gly Trp Leu Ile Leu Gly Arg Tyr Thr Gly Ile Tyr Asn
50 55 60
aca cct tgg gtg att ttg ggt gca tat gtg tgt gct ttt acc gcg ctg 240
Thr Pro Trp Val Ile Leu Gly Ala Tyr Val Cys Ala Phe Thr Ala Leu
65 70 75 80
gtt gtc caa gct gta cgc gga cca ctc agt caa gca ccc gaa gca atc 288
Val Val Gln Ala Val Arg Gly Pro Leu Ser Gln Ala Pro Glu Ala Ile
85 90 95
gaa gaa gcc gca cga atc agc ggc gca ggc aga tta cga tcc atc atg 336
Glu Glu Ala Ala Arg Ile Ser Gly Ala Gly Arg Leu Arg Ser Ile Met
100 105 110
gac acc acc gga gcg atg gca att ccc gca gct ttc gcc ggc gca gtg 384
Asp Thr Thr Gly Ala Met Ala Ile Pro Ala Ala Phe Ala Gly Ala Val
115 120 125
ctg gtt gcg gta act gcg gtt cga gag tta acc gtg tcc att ttg ctc 432
Leu Val Ala Val Thr Ala Val Arg Glu Leu Thr Val Ser Ile Leu Leu
130 135 140
atc gcg ccg ggc acc acc acc ctg ggt gtg cag gtg ttc aat ttg cag 480
Ile Ala Pro Gly Thr Thr Thr Leu Gly Val Gln Val Phe Asn Leu Gln
145 150 155 160
cag gcg gga aat tac aat cag gca tcg gcg ttg tcg ttg atg ttt gcg 528
Gln Ala Gly Asn Tyr Asn Gln Ala Ser Ala Leu Ser Leu Met Phe Ala
165 170 175
att atc ggt atc gtg gcg ctc gcg ttg acg gtg cgc agc cag aag gag 576
Ile Ile Gly Ile Val Ala Leu Ala Leu Thr Val Arg Ser Gln Lys Glu
180 185 190
ttt taggtgtcat cgatcaaatt gcg 602
Phe
<210> 374
<211> 193
<212> PRT
<213> Corynebacterium glutamicum
<400> 374
Ser Leu Met Leu Ser Leu Gly Ala Ala Leu Ile Cys Gly Val Leu Gly
1 5 10 15
Trp Leu Ile Gly Val Leu Ile Thr Arg Thr Gln His Phe Ala Asn Val
20 25 30
Pro Leu Thr Leu Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met Ile
35 40 45
Ile Gly Val Gly Trp Leu Ile Leu Gly Arg Tyr Thr Gly Ile Tyr Asn
50 55 60
Thr Pro Trp Val Ile Leu Gly Ala Tyr Val Cys Ala Phe Thr Ala Leu
65 70 75 80
Val Val Gln Ala Val Arg Gly Pro Leu Ser Gln Ala Pro Glu Ala Ile
85 90 95
Glu Glu Ala Ala Arg Ile Ser Gly Ala Gly Arg Leu Arg Ser Ile Met
100 105 110
Asp Thr Thr Gly Ala Met Ala Ile Pro Ala Ala Phe Ala Gly Ala Val
115 120 125
Leu Val Ala Val Thr Ala Val Arg Glu Leu Thr Val Ser Ile Leu Leu
130 135 140
Ile Ala Pro Gly Thr Thr Thr Leu Gly Val Gln Val Phe Asn Leu Gln
145 150 155 160
Gln Ala Gly Asn Tyr Asn Gln Ala Ser Ala Leu Ser Leu Met Phe Ala
165 170 175
Ile Ile Gly Ile Val Ala Leu Ala Leu Thr Val Arg Ser Gln Lys Glu
180 185 190
Phe
<210> 375
<211> 798
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(798)
<223> FRXA00370
<400> 375
ggc aaa gcc cta tgg aat tcc gcc tat aca aca gtg ctt tct gcg gtg 48
Gly Lys Ala Leu Trp Asn Ser Ala Tyr Thr Thr Val Leu Ser Ala Val
1 5 10 15
ggc gcg acc att atc ggc acg atc atg gct ctc acg ctg gac cga act 96
Gly Ala Thr Ile Ile Gly Thr Ile Met Ala Leu Thr Leu Asp Arg Thr
20 25 30
gat gtt ttc ggg cgc acc gcg ttg cgg tta ttt ttg tta tcc ccg ctg 144
Asp Val Phe Gly Arg Thr Ala Leu Arg Leu Phe Leu Leu Ser Pro Leu
35 40 45
ttg atc cct ccg ttt att ggg gct att gcg tgg ttg cag ctg ttc ggg 192
Leu Ile Pro Pro Phe Ile Gly Ala Ile Ala Trp Leu Gln Leu Phe Gly
50 55 60
aag aac cag ggc atc aac cgg ttt ttc ggc acg gaa gtg tgg gat att 240
Lys Asn Gln Gly Ile Asn Arg Phe Phe Gly Thr Glu Val Trp Asp Ile
65 70 75 80
tac ggc gct gat ggt gtg aca ttt ttg ttg att gtg cac tcc tat ccc 288
Tyr Gly Ala Asp Gly Val Thr Phe Leu Leu Ile Val His Ser Tyr Pro
85 90 95
act gtg tac atc att gtt tcg gca gct ctg agg caa ctt cct agt gat 336
Thr Val Tyr Ile Ile Val Ser Ala Ala Leu Arg Gln Leu Pro Ser Asp
100 105 110
ttg gag caa gct gca cgg atc gcg ggg gcg gat act ttt acg gtg ttg 384
Leu Glu Gln Ala Ala Arg Ile Ala Gly Ala Asp Thr Phe Thr Val Leu
115 120 125
cgc acc atc aca ctc cca ctg ctc aaa cct gca ttg ttg tcg gcg ttt 432
Arg Thr Ile Thr Leu Pro Leu Leu Lys Pro Ala Leu Leu Ser Ala Phe
130 135 140
act ctt acc aca gtg gcg aac ctc gcc gac ttt ggc att cca gct ctg 480
Thr Leu Thr Thr Val Ala Asn Leu Ala Asp Phe Gly Ile Pro Ala Leu
145 150 155 160
ttg gga tcg cca gcg cgt ttt gaa acc tta gcc acc atg att tat cgc 528
Leu Gly Ser Pro Ala Arg Phe Glu Thr Leu Ala Thr Met Ile Tyr Arg
165 170 175
ttc atg gaa tcc ggc acc gtg agc aat cca ttg cag gtg gta tcc acc 576
Phe Met Glu Ser Gly Thr Val Ser Asn Pro Leu Gln Val Val Ser Thr
180 185 190
att ggc atc gtg ttg ttg ttc ctg gga atc gca gca gta acc gcg gat 624
Ile Gly Ile Val Leu Leu Phe Leu Gly Ile Ala Ala Val Thr Ala Asp
195 200 205
tat ctg gtg tct ttg tac gcg gca tca aag ttg caa gac gca gga aca 672
Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys Leu Gln Asp Ala Gly Thr
210 215 220
ccg cat cgc ttt act ctc aac aaa tca cga atc cca gtc agc gtg atc 720
Pro His Arg Phe Thr Leu Asn Lys Ser Arg Ile Pro Val Ser Val Ile
225 230 235 240
acg tgg atc atc gcg ttg atc atc acc gcc gcc ccg ctg ctg ggt ctg 768
Thr Trp Ile Ile Ala Leu Ile Ile Thr Ala Ala Pro Leu Leu Gly Leu
245 250 255
gca tac aga gca tta ctg cct gcc cca ggt 798
Ala Tyr Arg Ala Leu Leu Pro Ala Pro Gly
260 265
<210> 376
<211> 266
<212> PRT
<213> Corynebacterium glutamicum
<400> 376
Gly Lys Ala Leu Trp Asn Ser Ala Tyr Thr Thr Val Leu Ser Ala Val
1 5 10 15
Gly Ala Thr Ile Ile Gly Thr Ile Met Ala Leu Thr Leu Asp Arg Thr
20 25 30
Asp Val Phe Gly Arg Thr Ala Leu Arg Leu Phe Leu Leu Ser Pro Leu
35 40 45
Leu Ile Pro Pro Phe Ile Gly Ala Ile Ala Trp Leu Gln Leu Phe Gly
50 55 60
Lys Asn Gln Gly Ile Asn Arg Phe Phe Gly Thr Glu Val Trp Asp Ile
65 70 75 80
Tyr Gly Ala Asp Gly Val Thr Phe Leu Leu Ile Val His Ser Tyr Pro
85 90 95
Thr Val Tyr Ile Ile Val Ser Ala Ala Leu Arg Gln Leu Pro Ser Asp
100 105 110
Leu Glu Gln Ala Ala Arg Ile Ala Gly Ala Asp Thr Phe Thr Val Leu
115 120 125
Arg Thr Ile Thr Leu Pro Leu Leu Lys Pro Ala Leu Leu Ser Ala Phe
130 135 140
Thr Leu Thr Thr Val Ala Asn Leu Ala Asp Phe Gly Ile Pro Ala Leu
145 150 155 160
Leu Gly Ser Pro Ala Arg Phe Glu Thr Leu Ala Thr Met Ile Tyr Arg
165 170 175
Phe Met Glu Ser Gly Thr Val Ser Asn Pro Leu Gln Val Val Ser Thr
180 185 190
Ile Gly Ile Val Leu Leu Phe Leu Gly Ile Ala Ala Val Thr Ala Asp
195 200 205
Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys Leu Gln Asp Ala Gly Thr
210 215 220
Pro His Arg Phe Thr Leu Asn Lys Ser Arg Ile Pro Val Ser Val Ile
225 230 235 240
Thr Trp Ile Ile Ala Leu Ile Ile Thr Ala Ala Pro Leu Leu Gly Leu
245 250 255
Ala Tyr Arg Ala Leu Leu Pro Ala Pro Gly
260 265
<210> 377
<211> 749
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(726)
<223> RXN01285
<400> 377
ctc aac gtc acc atc ccc gac aac acc ttc acc gcc atc atc ggc ccc 48
Leu Asn Val Thr Ile Pro Asp Asn Thr Phe Thr Ala Ile Ile Gly Pro
1 5 10 15
aac ggc tgc ggc aaa tcc acc ctg ctc cgc ggt ttc tcc cgc gtg ctc 96
Asn Gly Cys Gly Lys Ser Thr Leu Leu Arg Gly Phe Ser Arg Val Leu
20 25 30
aat ccg cag cac ggc aaa gtg ctt ctc gac ggt cgg caa ctc gat tca 144
Asn Pro Gln His Gly Lys Val Leu Leu Asp Gly Arg Gln Leu Asp Ser
35 40 45
ttc aag cct aaa gag atc gcc cga gaa cta ggc ctg ctg cca cag acc 192
Phe Lys Pro Lys Glu Ile Ala Arg Glu Leu Gly Leu Leu Pro Gln Thr
50 55 60
tcc atc gcc cca gaa ggc atc cgg gtt tac gat ctc atc gcg cgc ggg 240
Ser Ile Ala Pro Glu Gly Ile Arg Val Tyr Asp Leu Ile Ala Arg Gly
65 70 75 80
cgc gct ccc tac caa agc ctc ata caa caa tgg cgc acc tcc gac gaa 288
Arg Ala Pro Tyr Gln Ser Leu Ile Gln Gln Trp Arg Thr Ser Asp Glu
85 90 95
gac gcc gtc gcg caa gcg ctc gcc tcc acg aat ctc acc gaa ctt gca 336
Asp Ala Val Ala Gln Ala Leu Ala Ser Thr Asn Leu Thr Glu Leu Ala
100 105 110
gct cgc ctc gtc gat gaa ctc tcc ggt ggc cag cgc caa cga gtg tgg 384
Ala Arg Leu Val Asp Glu Leu Ser Gly Gly Gln Arg Gln Arg Val Trp
115 120 125
gtg gcc atg ttg ctc gcc cag caa aca ccg atc atg ctt ctc gac gag 432
Val Ala Met Leu Leu Ala Gln Gln Thr Pro Ile Met Leu Leu Asp Glu
130 135 140
ccc acc acc ttc ctc gac atc gcc cac caa tac gaa ctc ttg gaa ttg 480
Pro Thr Thr Phe Leu Asp Ile Ala His Gln Tyr Glu Leu Leu Glu Leu
145 150 155 160
ctg cgc gca ttc aac gag gcc ggg aaa act gtg gtc act gtg ctt cac 528
Leu Arg Ala Phe Asn Glu Ala Gly Lys Thr Val Val Thr Val Leu His
165 170 175
gat ctc aac caa gcc gcc cgc tac gcc gac cac ctc atc gtg atg aaa 576
Asp Leu Asn Gln Ala Ala Arg Tyr Ala Asp His Leu Ile Val Met Lys
180 185 190
gat ggg cac gta cat gcc acg ggc aca ccg gag gaa gtc tta act gcc 624
Asp Gly His Val His Ala Thr Gly Thr Pro Glu Glu Val Leu Thr Ala
195 200 205
gag atg gtt caa gga gtt ttt ggc ctg ccc tgc atc atc tcc cca gac 672
Glu Met Val Gln Gly Val Phe Gly Leu Pro Cys Ile Ile Ser Pro Asp
210 215 220
ccc gtc aca gga acc ccc acc gtc gtt ccc ctc agt cgg tct cgc gca 720
Pro Val Thr Gly Thr Pro Thr Val Val Pro Leu Ser Arg Ser Arg Ala
225 230 235 240
gga gct taagtagcta cccctccaac gga 749
Gly Ala
<210> 378
<211> 242
<212> PRT
<213> Corynebacterium glutamicum
<400> 378
Leu Asn Val Thr Ile Pro Asp Asn Thr Phe Thr Ala Ile Ile Gly Pro
1 5 10 15
Asn Gly Cys Gly Lys Ser Thr Leu Leu Arg Gly Phe Ser Arg Val Leu
20 25 30
Asn Pro Gln His Gly Lys Val Leu Leu Asp Gly Arg Gln Leu Asp Ser
35 40 45
Phe Lys Pro Lys Glu Ile Ala Arg Glu Leu Gly Leu Leu Pro Gln Thr
50 55 60
Ser Ile Ala Pro Glu Gly Ile Arg Val Tyr Asp Leu Ile Ala Arg Gly
65 70 75 80
Arg Ala Pro Tyr Gln Ser Leu Ile Gln Gln Trp Arg Thr Ser Asp Glu
85 90 95
Asp Ala Val Ala Gln Ala Leu Ala Ser Thr Asn Leu Thr Glu Leu Ala
100 105 110
Ala Arg Leu Val Asp Glu Leu Ser Gly Gly Gln Arg Gln Arg Val Trp
115 120 125
Val Ala Met Leu Leu Ala Gln Gln Thr Pro Ile Met Leu Leu Asp Glu
130 135 140
Pro Thr Thr Phe Leu Asp Ile Ala His Gln Tyr Glu Leu Leu Glu Leu
145 150 155 160
Leu Arg Ala Phe Asn Glu Ala Gly Lys Thr Val Val Thr Val Leu His
165 170 175
Asp Leu Asn Gln Ala Ala Arg Tyr Ala Asp His Leu Ile Val Met Lys
180 185 190
Asp Gly His Val His Ala Thr Gly Thr Pro Glu Glu Val Leu Thr Ala
195 200 205
Glu Met Val Gln Gly Val Phe Gly Leu Pro Cys Ile Ile Ser Pro Asp
210 215 220
Pro Val Thr Gly Thr Pro Thr Val Val Pro Leu Ser Arg Ser Arg Ala
225 230 235 240
Gly Ala
<210> 379
<211> 1149
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1126)
<223> RXN00523
<400> 379
tggtgactcg tccgagtgaa attgccgtgg gcatcatcat gccgatcatt ggtgcgccac 60
tgtttatttg gattattcgt cgtcagaaag tcaaagagct atg agc ctt agc cat 115
Met Ser Leu Ser His
1 5
caa ctc aag cgc cag cgc gca tcg cgc aac tcc cgc agg tgg ctg att 163
Gln Leu Lys Arg Gln Arg Ala Ser Arg Asn Ser Arg Arg Trp Leu Ile
10 15 20
gtt gcg gca ttg ggc gtc gtc acg ctt ggt att ttt gct ttt tct ttg 211
Val Ala Ala Leu Gly Val Val Thr Leu Gly Ile Phe Ala Phe Ser Leu
25 30 35
atg tgg ggc gag gtg ttt tat ggc cct gct cag gtg ctg aaa gtg ttg 259
Met Trp Gly Glu Val Phe Tyr Gly Pro Ala Gln Val Leu Lys Val Leu
40 45 50
tct gga cag cag gtt ccc ggc gcg agt tat tcc gtt ggc gtg ttg cgt 307
Ser Gly Gln Gln Val Pro Gly Ala Ser Tyr Ser Val Gly Val Leu Arg
55 60 65
ttg ccg cgc gcg gtg atg ggt ttg act gcg ggt ttg gcg ttt ggc gcg 355
Leu Pro Arg Ala Val Met Gly Leu Thr Ala Gly Leu Ala Phe Gly Ala
70 75 80 85
gcg ggc gtg att ttt cag acg gtg ttg cgt aat cag ttg gcg tcg ccg 403
Ala Gly Val Ile Phe Gln Thr Val Leu Arg Asn Gln Leu Ala Ser Pro
90 95 100
gat att atc ggc att tct tct ggc gcg tcg gcg gcg ggc gta att tgc 451
Asp Ile Ile Gly Ile Ser Ser Gly Ala Ser Ala Ala Gly Val Ile Cys
105 110 115
att gtg ttt ttc ggg atg tcg cag tct gca gtg tcg gcg att tct ttg 499
Ile Val Phe Phe Gly Met Ser Gln Ser Ala Val Ser Ala Ile Ser Leu
120 125 130
tgt gcg tcc ttg gct gtg gcg ttg ttg att tat ctg gtg gcg tat cgc 547
Cys Ala Ser Leu Ala Val Ala Leu Leu Ile Tyr Leu Val Ala Tyr Arg
135 140 145
ggt ggt ttt tcg gcc acg cgt ctg att ctt acc ggc att ggt att gct 595
Gly Gly Phe Ser Ala Thr Arg Leu Ile Leu Thr Gly Ile Gly Ile Ala
150 155 160 165
gcg atg ctg aat tca tta gtg tcg tat tcg ctg tcc aag gct gat tct 643
Ala Met Leu Asn Ser Leu Val Ser Tyr Ser Leu Ser Lys Ala Asp Ser
170 175 180
tgg gat ctg ccg acc gcg acg cgc tgg ctt acc ggc tcg ctc aat ggt 691
Trp Asp Leu Pro Thr Ala Thr Arg Trp Leu Thr Gly Ser Leu Asn Gly
185 190 195
gcg acg tgg gat cgt gcg atg ccg ctg att gtc acc act gtg gta ctc 739
Ala Thr Trp Asp Arg Ala Met Pro Leu Ile Val Thr Thr Val Val Leu
200 205 210
att ccg ctg ctg gtg gct aat gcg cgc aat gtg gat ctt atg cgt ttg 787
Ile Pro Leu Leu Val Ala Asn Ala Arg Asn Val Asp Leu Met Arg Leu
215 220 225
ggc aat gat tcc gcg gtg ggt ttg ggc gtt gct act aat cgc acg cgc 835
Gly Asn Asp Ser Ala Val Gly Leu Gly Val Ala Thr Asn Arg Thr Arg
230 235 240 245
gtc att gcg att att gcc gct gtt gcg ctc atc gcc gtt gct acc gct 883
Val Ile Ala Ile Ile Ala Ala Val Ala Leu Ile Ala Val Ala Thr Ala
250 255 260
gca tgc ggc ccg atc gca ttc gtg gcg ttt gtg tct ggc ccc att gcc 931
Ala Cys Gly Pro Ile Ala Phe Val Ala Phe Val Ser Gly Pro Ile Ala
265 270 275
gcg cgc att tta ggc tcc ggc gga tcg ctc atc atc ccc tcc gca ctc 979
Ala Arg Ile Leu Gly Ser Gly Gly Ser Leu Ile Ile Pro Ser Ala Leu
280 285 290
atc ggc ggg ttg atc gtg ctc atc gcc gac cta att ggc caa tac ttc 1027
Ile Gly Gly Leu Ile Val Leu Ile Ala Asp Leu Ile Gly Gln Tyr Phe
295 300 305
ctc ggc acc cgc tac ccc gtc gga gtt gtc acc ggc gca ttc ggc gcc 1075
Leu Gly Thr Arg Tyr Pro Val Gly Val Val Thr Gly Ala Phe Gly Ala
310 315 320 325
cca ttc ctt atc tat tta ctc att cgt tcc aac cgc gcg gga gta acc 1123
Pro Phe Leu Ile Tyr Leu Leu Ile Arg Ser Asn Arg Ala Gly Val Thr
330 335 340
ctg tgaccaccaa ccatcaacta tcc 1149
Leu
<210> 380
<211> 342
<212> PRT
<213> Corynebacterium glutamicum
<400> 380
Met Ser Leu Ser His Gln Leu Lys Arg Gln Arg Ala Ser Arg Asn Ser
1 5 10 15
Arg Arg Trp Leu Ile Val Ala Ala Leu Gly Val Val Thr Leu Gly Ile
20 25 30
Phe Ala Phe Ser Leu Met Trp Gly Glu Val Phe Tyr Gly Pro Ala Gln
35 40 45
Val Leu Lys Val Leu Ser Gly Gln Gln Val Pro Gly Ala Ser Tyr Ser
50 55 60
Val Gly Val Leu Arg Leu Pro Arg Ala Val Met Gly Leu Thr Ala Gly
65 70 75 80
Leu Ala Phe Gly Ala Ala Gly Val Ile Phe Gln Thr Val Leu Arg Asn
85 90 95
Gln Leu Ala Ser Pro Asp Ile Ile Gly Ile Ser Ser Gly Ala Ser Ala
100 105 110
Ala Gly Val Ile Cys Ile Val Phe Phe Gly Met Ser Gln Ser Ala Val
115 120 125
Ser Ala Ile Ser Leu Cys Ala Ser Leu Ala Val Ala Leu Leu Ile Tyr
130 135 140
Leu Val Ala Tyr Arg Gly Gly Phe Ser Ala Thr Arg Leu Ile Leu Thr
145 150 155 160
Gly Ile Gly Ile Ala Ala Met Leu Asn Ser Leu Val Ser Tyr Ser Leu
165 170 175
Ser Lys Ala Asp Ser Trp Asp Leu Pro Thr Ala Thr Arg Trp Leu Thr
180 185 190
Gly Ser Leu Asn Gly Ala Thr Trp Asp Arg Ala Met Pro Leu Ile Val
195 200 205
Thr Thr Val Val Leu Ile Pro Leu Leu Val Ala Asn Ala Arg Asn Val
210 215 220
Asp Leu Met Arg Leu Gly Asn Asp Ser Ala Val Gly Leu Gly Val Ala
225 230 235 240
Thr Asn Arg Thr Arg Val Ile Ala Ile Ile Ala Ala Val Ala Leu Ile
245 250 255
Ala Val Ala Thr Ala Ala Cys Gly Pro Ile Ala Phe Val Ala Phe Val
260 265 270
Ser Gly Pro Ile Ala Ala Arg Ile Leu Gly Ser Gly Gly Ser Leu Ile
275 280 285
Ile Pro Ser Ala Leu Ile Gly Gly Leu Ile Val Leu Ile Ala Asp Leu
290 295 300
Ile Gly Gln Tyr Phe Leu Gly Thr Arg Tyr Pro Val Gly Val Val Thr
305 310 315 320
Gly Ala Phe Gly Ala Pro Phe Leu Ile Tyr Leu Leu Ile Arg Ser Asn
325 330 335
Arg Ala Gly Val Thr Leu
340
<210> 381
<211> 621
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(598)
<223> RXN01142
<400> 381
ctccccatcc accggcacag tcagcgcagg caacgaagaa attaaaggac caggacctga 60
ccgaggcatg gttttccaag accacgccct cctgccctga ttg acc gca cgc ggc 115
Leu Thr Ala Arg Gly
1 5
aac atc gac ttc ggg ctc cgc tcc gcg cgc ccc tcc ttg agc aaa acc 163
Asn Ile Asp Phe Gly Leu Arg Ser Ala Arg Pro Ser Leu Ser Lys Thr
10 15 20
gaa cgc gcc gac atc acc cgc acc cac ctc gaa caa gta ggc ctc acc 211
Glu Arg Ala Asp Ile Thr Arg Thr His Leu Glu Gln Val Gly Leu Thr
25 30 35
gac gcc gcc gaa cgg cgc ccc gcc cgc ctc tcc ggc ggc atg caa cag 259
Asp Ala Ala Glu Arg Arg Pro Ala Arg Leu Ser Gly Gly Met Gln Gln
40 45 50
cga gtc ggc atc gca cgc gcc ttc gcc atc gac cca cca atc atg ctt 307
Arg Val Gly Ile Ala Arg Ala Phe Ala Ile Asp Pro Pro Ile Met Leu
55 60 65
ctc gac gaa ccc ttc ggc gcc ctc gac gcc ctc acc cgc cgc gaa ctc 355
Leu Asp Glu Pro Phe Gly Ala Leu Asp Ala Leu Thr Arg Arg Glu Leu
70 75 80 85
cag ctc caa cta ctc aac att tgg gaa gcc tcc cgc cgc acc gtc gtc 403
Gln Leu Gln Leu Leu Asn Ile Trp Glu Ala Ser Arg Arg Thr Val Val
90 95 100
atg gtc acc cac gac gtc gac gag gcc atc ctg ctc tcc gac cga gtt 451
Met Val Thr His Asp Val Asp Glu Ala Ile Leu Leu Ser Asp Arg Val
105 110 115
ctc gtg atg tcc aag agc ccc gaa gcc acc atc atc acc gat att cca 499
Leu Val Met Ser Lys Ser Pro Glu Ala Thr Ile Ile Thr Asp Ile Pro
120 125 130
gtg aat ctt ccc cgc ccc aga cac gag ctg agt gaa gac gct tct gtt 547
Val Asn Leu Pro Arg Pro Arg His Glu Leu Ser Glu Asp Ala Ser Val
135 140 145
gaa gcc gag acc aca gcc ctg cgt aag cgg atg ctg cat ctg ctg gag 595
Glu Ala Glu Thr Thr Ala Leu Arg Lys Arg Met Leu His Leu Leu Glu
150 155 160 165
cac tagtttctaa cacgtctttt aaa 621
His
<210> 382
<211> 166
<212> PRT
<213> Corynebacterium glutamicum
<400> 382
Leu Thr Ala Arg Gly Asn Ile Asp Phe Gly Leu Arg Ser Ala Arg Pro
1 5 10 15
Ser Leu Ser Lys Thr Glu Arg Ala Asp Ile Thr Arg Thr His Leu Glu
20 25 30
Gln Val Gly Leu Thr Asp Ala Ala Glu Arg Arg Pro Ala Arg Leu Ser
35 40 45
Gly Gly Met Gln Gln Arg Val Gly Ile Ala Arg Ala Phe Ala Ile Asp
50 55 60
Pro Pro Ile Met Leu Leu Asp Glu Pro Phe Gly Ala Leu Asp Ala Leu
65 70 75 80
Thr Arg Arg Glu Leu Gln Leu Gln Leu Leu Asn Ile Trp Glu Ala Ser
85 90 95
Arg Arg Thr Val Val Met Val Thr His Asp Val Asp Glu Ala Ile Leu
100 105 110
Leu Ser Asp Arg Val Leu Val Met Ser Lys Ser Pro Glu Ala Thr Ile
115 120 125
Ile Thr Asp Ile Pro Val Asn Leu Pro Arg Pro Arg His Glu Leu Ser
130 135 140
Glu Asp Ala Ser Val Glu Ala Glu Thr Thr Ala Leu Arg Lys Arg Met
145 150 155 160
Leu His Leu Leu Glu His
165
<210> 383
<211> 948
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(925)
<223> RXN01141
<400> 383
aaagaacact cggtatggca cctgatttaa ggatgctgca atcgtgacac atatcctctt 60
cgacagcagg cgttttctgc aactgggcgc ttttgcgtcc ttg agc acc gca ttg 115
Leu Ser Thr Ala Leu
1 5
gcc gga gcg gcc cgc tac gtg acg tcg aca agc aat aat gaa cct gcg 163
Ala Gly Ala Ala Arg Tyr Val Thr Ser Thr Ser Asn Asn Glu Pro Ala
10 15 20
gat aac act ccc ctg acc att ggc tac gtg cct att gcg ggc tcg gcg 211
Asp Asn Thr Pro Leu Thr Ile Gly Tyr Val Pro Ile Ala Gly Ser Ala
25 30 35
ccg att gct atc gca gat gcg cta ggg ctg ttt aag aaa cac ggc gtg 259
Pro Ile Ala Ile Ala Asp Ala Leu Gly Leu Phe Lys Lys His Gly Val
40 45 50
aat gtc acg ttg aag aag tac tca ggc tgg tcc gac ctg tgg acc gcc 307
Asn Val Thr Leu Lys Lys Tyr Ser Gly Trp Ser Asp Leu Trp Thr Ala
55 60 65
tat gca aca gag cag ctt gat gtt gcg cac atg ctg tcg ccg atg act 355
Tyr Ala Thr Glu Gln Leu Asp Val Ala His Met Leu Ser Pro Met Thr
70 75 80 85
gtg gcg att aat gct gga gtg acc aac gcg tcg cgc ccg acg gag ctg 403
Val Ala Ile Asn Ala Gly Val Thr Asn Ala Ser Arg Pro Thr Glu Leu
90 95 100
tcg ttt acc cag aac acc aat ggg caa gca att acc ttg gcg tca aag 451
Ser Phe Thr Gln Asn Thr Asn Gly Gln Ala Ile Thr Leu Ala Ser Lys
105 110 115
cac tat ggt tcc gtc aat tca gcg gcg gat ctt aaa ggc atg gtg ctg 499
His Tyr Gly Ser Val Asn Ser Ala Ala Asp Leu Lys Gly Met Val Leu
120 125 130
gga att cct ttt gaa tat tca gtc cat gcg ctg ctc ctg cgc gat tat 547
Gly Ile Pro Phe Glu Tyr Ser Val His Ala Leu Leu Leu Arg Asp Tyr
135 140 145
ctc gtc tca aac gca gtt gat ccc atc gcc gat ctt gag ctt cgc ctg 595
Leu Val Ser Asn Ala Val Asp Pro Ile Ala Asp Leu Glu Leu Arg Leu
150 155 160 165
ctc cga cct gcc gat atg gtc gca caa ttg aca gtt gag ggc atc gat 643
Leu Arg Pro Ala Asp Met Val Ala Gln Leu Thr Val Glu Gly Ile Asp
170 175 180
gga ttc att ggg cct ggg ccg ttt aat gaa cgc gcc atc agc aat ggc 691
Gly Phe Ile Gly Pro Gly Pro Phe Asn Glu Arg Ala Ile Ser Asn Gly
185 190 195
tcc ggc cgg att tgg ctg ctg acc aaa caa ctg tgg gac aaa cat cca 739
Ser Gly Arg Ile Trp Leu Leu Thr Lys Gln Leu Trp Asp Lys His Pro
200 205 210
tgc tgc gcc gtg gcg atg gcc aaa gag tgg aaa gct gaa cac ccc acg 787
Cys Cys Ala Val Ala Met Ala Lys Glu Trp Lys Ala Glu His Pro Thr
215 220 225
gcg gct cag ggt gtg ctt aat gcg ctg gag gaa gcc tcc gca att ttg 835
Ala Ala Gln Gly Val Leu Asn Ala Leu Glu Glu Ala Ser Ala Ile Leu
230 235 240 245
agc aat ccg gca caa ttt gat tcc tcg gca cgc acg ctg tcg cag gaa 883
Ser Asn Pro Ala Gln Phe Asp Ser Ser Ala Arg Thr Leu Ser Gln Glu
250 255 260
aaa tac ctc aac cag cct gcc acg ttg ctg gat gga ccg tcg 925
Lys Tyr Leu Asn Gln Pro Ala Thr Leu Leu Asp Gly Pro Ser
265 270 275
taatcatcgg catcaccggc tta 948
<210> 384
<211> 275
<212> PRT
<213> Corynebacterium glutamicum
<400> 384
Leu Ser Thr Ala Leu Ala Gly Ala Ala Arg Tyr Val Thr Ser Thr Ser
1 5 10 15
Asn Asn Glu Pro Ala Asp Asn Thr Pro Leu Thr Ile Gly Tyr Val Pro
20 25 30
Ile Ala Gly Ser Ala Pro Ile Ala Ile Ala Asp Ala Leu Gly Leu Phe
35 40 45
Lys Lys His Gly Val Asn Val Thr Leu Lys Lys Tyr Ser Gly Trp Ser
50 55 60
Asp Leu Trp Thr Ala Tyr Ala Thr Glu Gln Leu Asp Val Ala His Met
65 70 75 80
Leu Ser Pro Met Thr Val Ala Ile Asn Ala Gly Val Thr Asn Ala Ser
85 90 95
Arg Pro Thr Glu Leu Ser Phe Thr Gln Asn Thr Asn Gly Gln Ala Ile
100 105 110
Thr Leu Ala Ser Lys His Tyr Gly Ser Val Asn Ser Ala Ala Asp Leu
115 120 125
Lys Gly Met Val Leu Gly Ile Pro Phe Glu Tyr Ser Val His Ala Leu
130 135 140
Leu Leu Arg Asp Tyr Leu Val Ser Asn Ala Val Asp Pro Ile Ala Asp
145 150 155 160
Leu Glu Leu Arg Leu Leu Arg Pro Ala Asp Met Val Ala Gln Leu Thr
165 170 175
Val Glu Gly Ile Asp Gly Phe Ile Gly Pro Gly Pro Phe Asn Glu Arg
180 185 190
Ala Ile Ser Asn Gly Ser Gly Arg Ile Trp Leu Leu Thr Lys Gln Leu
195 200 205
Trp Asp Lys His Pro Cys Cys Ala Val Ala Met Ala Lys Glu Trp Lys
210 215 220
Ala Glu His Pro Thr Ala Ala Gln Gly Val Leu Asn Ala Leu Glu Glu
225 230 235 240
Ala Ser Ala Ile Leu Ser Asn Pro Ala Gln Phe Asp Ser Ser Ala Arg
245 250 255
Thr Leu Ser Gln Glu Lys Tyr Leu Asn Gln Pro Ala Thr Leu Leu Asp
260 265 270
Gly Pro Ser
275
<210> 385
<211> 927
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(904)
<223> RXN01002
<400> 385
gactgctgat accgcacagg atgaaatcac tcgttacggc gagatcctga agaagttctc 60
caactaattt ccctgtttcc aatactcaag gtgtgcgcat atg aat tct gat gct 115
Met Asn Ser Asp Ala
1 5
tcg gct acc acc aac tcc tgg gct atc aac ttc gac cat gtg tcg gtg 163
Ser Ala Thr Thr Asn Ser Trp Ala Ile Asn Phe Asp His Val Ser Val
10 15 20
acg tat ccc aat ggg acg aaa gcc ctc gat gat gtt tcc ctc acc atc 211
Thr Tyr Pro Asn Gly Thr Lys Ala Leu Asp Asp Val Ser Leu Thr Ile
25 30 35
aat ccc ggt gag atg gtt gcc atc gtg ggt ctg tca gga tcg ggt aaa 259
Asn Pro Gly Glu Met Val Ala Ile Val Gly Leu Ser Gly Ser Gly Lys
40 45 50
tcc acg ctg att cgc acg atc aac ggt ctt gtc cgc gct acg gaa ggc 307
Ser Thr Leu Ile Arg Thr Ile Asn Gly Leu Val Arg Ala Thr Glu Gly
55 60 65
acc gtg acg gtg ggg ccg cat cag atc aac acc ttg aag ggg aaa gca 355
Thr Val Thr Val Gly Pro His Gln Ile Asn Thr Leu Lys Gly Lys Ala
70 75 80 85
ctg cgt gat gcc cgt ggg cag atc ggc atg att ttc cag ggg ttc aac 403
Leu Arg Asp Ala Arg Gly Gln Ile Gly Met Ile Phe Gln Gly Phe Asn
90 95 100
ctg tcg gaa cgc agc agt gtg ttc cag aat gtt ttg gtg ggc cgc ttc 451
Leu Ser Glu Arg Ser Ser Val Phe Gln Asn Val Leu Val Gly Arg Phe
105 110 115
gcg cac aca gcg tgg tgg cgt aac ctc ctc ggg ttt ccc acg gag cac 499
Ala His Thr Ala Trp Trp Arg Asn Leu Leu Gly Phe Pro Thr Glu His
120 125 130
gac aag cag att gct ttt cac gcg ttg gag tcc gtg ggc att ttg cac 547
Asp Lys Gln Ile Ala Phe His Ala Leu Glu Ser Val Gly Ile Leu His
135 140 145
aaa gtg tgg acc cga gct ggt gct ttg tcg ggt gga cag aaa cag cgc 595
Lys Val Trp Thr Arg Ala Gly Ala Leu Ser Gly Gly Gln Lys Gln Arg
150 155 160 165
gtt gct att gcg cgc gcc tta tcg caa gat ccg tct gtc atg ctg gca 643
Val Ala Ile Ala Arg Ala Leu Ser Gln Asp Pro Ser Val Met Leu Ala
170 175 180
gat gag cct gtg gca agc ctt gat ccg cca acc gcg cat tcc gtg atg 691
Asp Glu Pro Val Ala Ser Leu Asp Pro Pro Thr Ala His Ser Val Met
185 190 195
cgc gat cta gaa aac atc aac aac gtg gaa ggc ctc acc gtg ttg gtg 739
Arg Asp Leu Glu Asn Ile Asn Asn Val Glu Gly Leu Thr Val Leu Val
200 205 210
aac ttg cac ttg att gat ttg gct cgt caa tac acc aca agg ctt gtg 787
Asn Leu His Leu Ile Asp Leu Ala Arg Gln Tyr Thr Thr Arg Leu Val
215 220 225
ggt ttg cgt gcc ggc aag ctg gtc tat gac ggt cct atc tct gag gcc 835
Gly Leu Arg Ala Gly Lys Leu Val Tyr Asp Gly Pro Ile Ser Glu Ala
230 235 240 245
acc gat aaa gac ttt gaa gct atc tat ggt cgc ccc atc cag gct aaa 883
Thr Asp Lys Asp Phe Glu Ala Ile Tyr Gly Arg Pro Ile Gln Ala Lys
250 255 260
gac ctg cta ggt gat cgc gca tgaccacgcc ttcttctaca ctt 927
Asp Leu Leu Gly Asp Arg Ala
265
<210> 386
<211> 268
<212> PRT
<213> Corynebacterium glutamicum
<400> 386
Met Asn Ser Asp Ala Ser Ala Thr Thr Asn Ser Trp Ala Ile Asn Phe
1 5 10 15
Asp His Val Ser Val Thr Tyr Pro Asn Gly Thr Lys Ala Leu Asp Asp
20 25 30
Val Ser Leu Thr Ile Asn Pro Gly Glu Met Val Ala Ile Val Gly Leu
35 40 45
Ser Gly Ser Gly Lys Ser Thr Leu Ile Arg Thr Ile Asn Gly Leu Val
50 55 60
Arg Ala Thr Glu Gly Thr Val Thr Val Gly Pro His Gln Ile Asn Thr
65 70 75 80
Leu Lys Gly Lys Ala Leu Arg Asp Ala Arg Gly Gln Ile Gly Met Ile
85 90 95
Phe Gln Gly Phe Asn Leu Ser Glu Arg Ser Ser Val Phe Gln Asn Val
100 105 110
Leu Val Gly Arg Phe Ala His Thr Ala Trp Trp Arg Asn Leu Leu Gly
115 120 125
Phe Pro Thr Glu His Asp Lys Gln Ile Ala Phe His Ala Leu Glu Ser
130 135 140
Val Gly Ile Leu His Lys Val Trp Thr Arg Ala Gly Ala Leu Ser Gly
145 150 155 160
Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ser Gln Asp Pro
165 170 175
Ser Val Met Leu Ala Asp Glu Pro Val Ala Ser Leu Asp Pro Pro Thr
180 185 190
Ala His Ser Val Met Arg Asp Leu Glu Asn Ile Asn Asn Val Glu Gly
195 200 205
Leu Thr Val Leu Val Asn Leu His Leu Ile Asp Leu Ala Arg Gln Tyr
210 215 220
Thr Thr Arg Leu Val Gly Leu Arg Ala Gly Lys Leu Val Tyr Asp Gly
225 230 235 240
Pro Ile Ser Glu Ala Thr Asp Lys Asp Phe Glu Ala Ile Tyr Gly Arg
245 250 255
Pro Ile Gln Ala Lys Asp Leu Leu Gly Asp Arg Ala
260 265
<210> 387
<211> 969
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(946)
<223> RXN01000
<400> 387
ctttctatgc ctacgcggat gtttccgtga tcattctgga aatcctcatc gtggtgattg 60
tcattgaagt aatctccaac gcacttcgaa agaggctggt atg agc acc tta acc 115
Met Ser Thr Leu Thr
1 5
tct cac cgc aca gta ccg gcc ccc agc tct ccc ccg gcg cgc ccc aac 163
Ser His Arg Thr Val Pro Ala Pro Ser Ser Pro Pro Ala Arg Pro Asn
10 15 20
aaa ctg gcg cgc aat atc gtt gca att gtc gct gcg ctg att gtc ctt 211
Lys Leu Ala Arg Asn Ile Val Ala Ile Val Ala Ala Leu Ile Val Leu
25 30 35
ata gct acc ggc acg ctc aag atc gag tgg aat gag ctt ccg cag atg 259
Ile Ala Thr Gly Thr Leu Lys Ile Glu Trp Asn Glu Leu Pro Gln Met
40 45 50
ccc gcg cag gtg tgg cat tac tta gag ctg atg ttt agc gat ccc gat 307
Pro Ala Gln Val Trp His Tyr Leu Glu Leu Met Phe Ser Asp Pro Asp
55 60 65
tgg tcg aag ttt ggc cgc gcc gtc cag gaa atg tgg cgt tcc atc gcc 355
Trp Ser Lys Phe Gly Arg Ala Val Gln Glu Met Trp Arg Ser Ile Ala
70 75 80 85
atg gcg tgg ttg ggt gcc att tta tgc gtg gtg gtc tct gtc cct ctg 403
Met Ala Trp Leu Gly Ala Ile Leu Cys Val Val Val Ser Val Pro Leu
90 95 100
gga atg ttg gct gcc cgc ggg gtg gga cct tat tgg ctg cgt acc gtt 451
Gly Met Leu Ala Ala Arg Gly Val Gly Pro Tyr Trp Leu Arg Thr Val
105 110 115
tta cgg ttc gtg ttc gcg gtg att cgt gcg ttc ccc gaa gtg gtt atc 499
Leu Arg Phe Val Phe Ala Val Ile Arg Ala Phe Pro Glu Val Val Ile
120 125 130
gca att att ttg cta act gtc acc ggc cta act cct ttt act ggt gcg 547
Ala Ile Ile Leu Leu Thr Val Thr Gly Leu Thr Pro Phe Thr Gly Ala
135 140 145
ctc gca ttg ggt atc tcc ggt att gga caa cag gca aag tgg acc tat 595
Leu Ala Leu Gly Ile Ser Gly Ile Gly Gln Gln Ala Lys Trp Thr Tyr
150 155 160 165
gaa gcc att gag tcc act ccc acc ggc ccg tca gag gca gtg cgt gca 643
Glu Ala Ile Glu Ser Thr Pro Thr Gly Pro Ser Glu Ala Val Arg Ala
170 175 180
gcg ggt gga act acg ccg gag gtt ctg cgg tgg gcg ttg tgg cca cag 691
Ala Gly Gly Thr Thr Pro Glu Val Leu Arg Trp Ala Leu Trp Pro Gln
185 190 195
gtt gcg cca tcc att gca tct ttt gcc ctg tac cgc ttt gag atc aac 739
Val Ala Pro Ser Ile Ala Ser Phe Ala Leu Tyr Arg Phe Glu Ile Asn
200 205 210
atc cgt acc tct gcg gta ttg ggc atc gtt ggt gca ggt ggt atc ggt 787
Ile Arg Thr Ser Ala Val Leu Gly Ile Val Gly Ala Gly Gly Ile Gly
215 220 225
agt atg ctt gcc aat tac acc aac tac agg cag tgg gac acc gtg ggc 835
Ser Met Leu Ala Asn Tyr Thr Asn Tyr Arg Gln Trp Asp Thr Val Gly
230 235 240 245
atg ctg ctc atc gtc gtg gtt gtc gca acg atg atc gtc gat ctc atc 883
Met Leu Leu Ile Val Val Val Val Ala Thr Met Ile Val Asp Leu Ile
250 255 260
tcc ggc acc atc cgc cgc cgc atc atg aag ggg gct agt gac cgt gtc 931
Ser Gly Thr Ile Arg Arg Arg Ile Met Lys Gly Ala Ser Asp Arg Val
265 270 275
gtg gca cca agc aac tgacgctcca ccaagcatcc gca 969
Val Ala Pro Ser Asn
280
<210> 388
<211> 282
<212> PRT
<213> Corynebacterium glutamicum
<400> 388
Met Ser Thr Leu Thr Ser His Arg Thr Val Pro Ala Pro Ser Ser Pro
1 5 10 15
Pro Ala Arg Pro Asn Lys Leu Ala Arg Asn Ile Val Ala Ile Val Ala
20 25 30
Ala Leu Ile Val Leu Ile Ala Thr Gly Thr Leu Lys Ile Glu Trp Asn
35 40 45
Glu Leu Pro Gln Met Pro Ala Gln Val Trp His Tyr Leu Glu Leu Met
50 55 60
Phe Ser Asp Pro Asp Trp Ser Lys Phe Gly Arg Ala Val Gln Glu Met
65 70 75 80
Trp Arg Ser Ile Ala Met Ala Trp Leu Gly Ala Ile Leu Cys Val Val
85 90 95
Val Ser Val Pro Leu Gly Met Leu Ala Ala Arg Gly Val Gly Pro Tyr
100 105 110
Trp Leu Arg Thr Val Leu Arg Phe Val Phe Ala Val Ile Arg Ala Phe
115 120 125
Pro Glu Val Val Ile Ala Ile Ile Leu Leu Thr Val Thr Gly Leu Thr
130 135 140
Pro Phe Thr Gly Ala Leu Ala Leu Gly Ile Ser Gly Ile Gly Gln Gln
145 150 155 160
Ala Lys Trp Thr Tyr Glu Ala Ile Glu Ser Thr Pro Thr Gly Pro Ser
165 170 175
Glu Ala Val Arg Ala Ala Gly Gly Thr Thr Pro Glu Val Leu Arg Trp
180 185 190
Ala Leu Trp Pro Gln Val Ala Pro Ser Ile Ala Ser Phe Ala Leu Tyr
195 200 205
Arg Phe Glu Ile Asn Ile Arg Thr Ser Ala Val Leu Gly Ile Val Gly
210 215 220
Ala Gly Gly Ile Gly Ser Met Leu Ala Asn Tyr Thr Asn Tyr Arg Gln
225 230 235 240
Trp Asp Thr Val Gly Met Leu Leu Ile Val Val Val Val Ala Thr Met
245 250 255
Ile Val Asp Leu Ile Ser Gly Thr Ile Arg Arg Arg Ile Met Lys Gly
260 265 270
Ala Ser Asp Arg Val Val Ala Pro Ser Asn
275 280
<210> 389
<211> 1173
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1150)
<223> RXN01732
<400> 389
gattctatcg ctgatctccc tctccttgcc tgggtttgtt cccgggtctc ctcttcttaa 60
ctttcttgtc tcatgtcgct gaaaggtttt taaagatctc atg ttc aag ctc tct 115
Met Phe Lys Leu Ser
1 5
aag cca tcc aag tcc atg cgt gtt gct gtt tct acg ctt gcg atc tct 163
Lys Pro Ser Lys Ser Met Arg Val Ala Val Ser Thr Leu Ala Ile Ser
10 15 20
acc ctt gct cta gtt ggt tgt tcc tct tcc gat gag tct tct tcc tca 211
Thr Leu Ala Leu Val Gly Cys Ser Ser Ser Asp Glu Ser Ser Ser Ser
25 30 35
tca tct gcg tct tct tct tcg gat gct gca agc cag tgg cct gag tcc 259
Ser Ser Ala Ser Ser Ser Ser Asp Ala Ala Ser Gln Trp Pro Glu Ser
40 45 50
att act ttg tct ctt gtt cct tct act gag ggt gag gat ttg gct gaa 307
Ile Thr Leu Ser Leu Val Pro Ser Thr Glu Gly Glu Asp Leu Ala Glu
55 60 65
gcg ttg gct cct ttg act gat tac ctg tct gag aac ctt ggt att gag 355
Ala Leu Ala Pro Leu Thr Asp Tyr Leu Ser Glu Asn Leu Gly Ile Glu
70 75 80 85
gtc aat ggt gtg gtg gcg tct gat tac gct gca acc gtt gag gct ttg 403
Val Asn Gly Val Val Ala Ser Asp Tyr Ala Ala Thr Val Glu Ala Leu
90 95 100
ggt gct gat cag gct cag gtg atc atc act gat gcg ggt tcc ctg tat 451
Gly Ala Asp Gln Ala Gln Val Ile Ile Thr Asp Ala Gly Ser Leu Tyr
105 110 115
aac gcg att gag cag tac gat gcg cag ctg att ctg cgt gat gtg cgt 499
Asn Ala Ile Glu Gln Tyr Asp Ala Gln Leu Ile Leu Arg Asp Val Arg
120 125 130
ttc ggt gcc acc tcg tac tct gct gtg gcg tac acc aac aat cct gat 547
Phe Gly Ala Thr Ser Tyr Ser Ala Val Ala Tyr Thr Asn Asn Pro Asp
135 140 145
aag tac tgc gac gat gcc cca gtg gct gcg tct tat gct gcg tcc gat 595
Lys Tyr Cys Asp Asp Ala Pro Val Ala Ala Ser Tyr Ala Ala Ser Asp
150 155 160 165
gta gac atg ctt tac tgc aac ggt att gaa act gag ggc cag gct gct 643
Val Asp Met Leu Tyr Cys Asn Gly Ile Glu Thr Glu Gly Gln Ala Ala
170 175 180
acc ggt gag ggc cca gca gct ctt gat gcg ctg gaa aag atc gag tcc 691
Thr Gly Glu Gly Pro Ala Ala Leu Asp Ala Leu Glu Lys Ile Glu Ser
185 190 195
ggt gac aag gta gcg ctg cag gct gca acc tct cct gcg ggt tac cag 739
Gly Asp Lys Val Ala Leu Gln Ala Ala Thr Ser Pro Ala Gly Tyr Gln
200 205 210
tac cct atc gtc gct atg cag gat ctg ggc atg gat acc gat tcc gct 787
Tyr Pro Ile Val Ala Met Gln Asp Leu Gly Met Asp Thr Asp Ser Ala
215 220 225
ttt gtt cag gtt cca gta gag ggc aac aac aac gct gtg ctg tct gtc 835
Phe Val Gln Val Pro Val Glu Gly Asn Asn Asn Ala Val Leu Ser Val
230 235 240 245
ctg aac ggt gac gcg gaa gtg tcc ttc ggt ttc tgg gat gcg cgt tcc 883
Leu Asn Gly Asp Ala Glu Val Ser Phe Gly Phe Trp Asp Ala Arg Ser
250 255 260
acc gtg ctg tct gag gct cct aac gca gct gag gat gtc gta gcg ttt 931
Thr Val Leu Ser Glu Ala Pro Asn Ala Ala Glu Asp Val Val Ala Phe
265 270 275
gcc tac acc gag atg atc cct aac ggt ggc gtc gca gcg tcc aag tcc 979
Ala Tyr Thr Glu Met Ile Pro Asn Gly Gly Val Ala Ala Ser Lys Ser
280 285 290
ctt cca tcc gac ctg gtg gaa aag ctc acc gag ttg atg gat gat tac 1027
Leu Pro Ser Asp Leu Val Glu Lys Leu Thr Glu Leu Met Asp Asp Tyr
295 300 305
gca gat tcc tcc gag gaa gcc aag gat gtc atg ttc gac atg gtt ggt 1075
Ala Asp Ser Ser Glu Glu Ala Lys Asp Val Met Phe Asp Met Val Gly
310 315 320 325
cta tct gac tgg act gct gat acc gca cag gat gaa atc act cgt tac 1123
Leu Ser Asp Trp Thr Ala Asp Thr Ala Gln Asp Glu Ile Thr Arg Tyr
330 335 340
ggc gag atc ctg aag aag ttc tcc aac taatttccct gtttccaata 1170
Gly Glu Ile Leu Lys Lys Phe Ser Asn
345 350
ctc 1173
<210> 390
<211> 350
<212> PRT
<213> Corynebacterium glutamicum
<400> 390
Met Phe Lys Leu Ser Lys Pro Ser Lys Ser Met Arg Val Ala Val Ser
1 5 10 15
Thr Leu Ala Ile Ser Thr Leu Ala Leu Val Gly Cys Ser Ser Ser Asp
20 25 30
Glu Ser Ser Ser Ser Ser Ser Ala Ser Ser Ser Ser Asp Ala Ala Ser
35 40 45
Gln Trp Pro Glu Ser Ile Thr Leu Ser Leu Val Pro Ser Thr Glu Gly
50 55 60
Glu Asp Leu Ala Glu Ala Leu Ala Pro Leu Thr Asp Tyr Leu Ser Glu
65 70 75 80
Asn Leu Gly Ile Glu Val Asn Gly Val Val Ala Ser Asp Tyr Ala Ala
85 90 95
Thr Val Glu Ala Leu Gly Ala Asp Gln Ala Gln Val Ile Ile Thr Asp
100 105 110
Ala Gly Ser Leu Tyr Asn Ala Ile Glu Gln Tyr Asp Ala Gln Leu Ile
115 120 125
Leu Arg Asp Val Arg Phe Gly Ala Thr Ser Tyr Ser Ala Val Ala Tyr
130 135 140
Thr Asn Asn Pro Asp Lys Tyr Cys Asp Asp Ala Pro Val Ala Ala Ser
145 150 155 160
Tyr Ala Ala Ser Asp Val Asp Met Leu Tyr Cys Asn Gly Ile Glu Thr
165 170 175
Glu Gly Gln Ala Ala Thr Gly Glu Gly Pro Ala Ala Leu Asp Ala Leu
180 185 190
Glu Lys Ile Glu Ser Gly Asp Lys Val Ala Leu Gln Ala Ala Thr Ser
195 200 205
Pro Ala Gly Tyr Gln Tyr Pro Ile Val Ala Met Gln Asp Leu Gly Met
210 215 220
Asp Thr Asp Ser Ala Phe Val Gln Val Pro Val Glu Gly Asn Asn Asn
225 230 235 240
Ala Val Leu Ser Val Leu Asn Gly Asp Ala Glu Val Ser Phe Gly Phe
245 250 255
Trp Asp Ala Arg Ser Thr Val Leu Ser Glu Ala Pro Asn Ala Ala Glu
260 265 270
Asp Val Val Ala Phe Ala Tyr Thr Glu Met Ile Pro Asn Gly Gly Val
275 280 285
Ala Ala Ser Lys Ser Leu Pro Ser Asp Leu Val Glu Lys Leu Thr Glu
290 295 300
Leu Met Asp Asp Tyr Ala Asp Ser Ser Glu Glu Ala Lys Asp Val Met
305 310 315 320
Phe Asp Met Val Gly Leu Ser Asp Trp Thr Ala Asp Thr Ala Gln Asp
325 330 335
Glu Ile Thr Arg Tyr Gly Glu Ile Leu Lys Lys Phe Ser Asn
340 345 350
<210> 391
<211> 903
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(880)
<223> RXN03080
<400> 391
cttgcaaaca ggcgtggtgg tggcgttcat tggctcacca attttccttt atttactgct 60
cagcatgcgc aagcgacgcg gattggggct gtaaaaactc atg cct caa tta gtt 115
Met Pro Gln Leu Val
1 5
gaa att cgt gat ctc aac gtt gaa ttc ccc tct cgc cat gca gtg aaa 163
Glu Ile Arg Asp Leu Asn Val Glu Phe Pro Ser Arg His Ala Val Lys
10 15 20
aac gtg tct ttt tct gca cct gct gga aaa gtc acc gca ctg att ggc 211
Asn Val Ser Phe Ser Ala Pro Ala Gly Lys Val Thr Ala Leu Ile Gly
25 30 35
cca aat ggt gct ggt aaa agt act gcc ctt tcg gcg att gca gga ttg 259
Pro Asn Gly Ala Gly Lys Ser Thr Ala Leu Ser Ala Ile Ala Gly Leu
40 45 50
gtt gaa tcc acc ggc gag gta atg gtt ggt ggg agt ggg gtt gcg tcg 307
Val Glu Ser Thr Gly Glu Val Met Val Gly Gly Ser Gly Val Ala Ser
55 60 65
aaa agc gct aaa gcc cga gcc cgc ctg ctc tca ctc gtg ccg caa aac 355
Lys Ser Ala Lys Ala Arg Ala Arg Leu Leu Ser Leu Val Pro Gln Asn
70 75 80 85
acc gag ttg cgc att ggt ttt agt gca cgc gac gtt gtc gcg atg ggc 403
Thr Glu Leu Arg Ile Gly Phe Ser Ala Arg Asp Val Val Ala Met Gly
90 95 100
cgc tac ccg cat cgt ggc cgc ttc gcc gtg gag acc gac gca gat cga 451
Arg Tyr Pro His Arg Gly Arg Phe Ala Val Glu Thr Asp Ala Asp Arg
105 110 115
cgc gcc acc gat gac gcc ctg cgc gcc atc aac gcg ctc gac atc gcc 499
Arg Ala Thr Asp Asp Ala Leu Arg Ala Ile Asn Ala Leu Asp Ile Ala
120 125 130
gag cag ccc gtc aac gaa tta tcg ggc ggc cag cag cag ctc atc cac 547
Glu Gln Pro Val Asn Glu Leu Ser Gly Gly Gln Gln Gln Leu Ile His
135 140 145
atc ggc cga gcg ctc gcc caa gac acc gcc gtc gtg ctt ctc gac gag 595
Ile Gly Arg Ala Leu Ala Gln Asp Thr Ala Val Val Leu Leu Asp Glu
150 155 160 165
ccc gtc tcc gcc ctt gat cta cgg cac caa gtt gaa gtc ctt caa ctc 643
Pro Val Ser Ala Leu Asp Leu Arg His Gln Val Glu Val Leu Gln Leu
170 175 180
ctg cgc gcc cga gct aat tcc ggc acc acc gtg atc gtc gtc ctt cac 691
Leu Arg Ala Arg Ala Asn Ser Gly Thr Thr Val Ile Val Val Leu His
185 190 195
gat ctc aac cac gtt gcc cgt tgg tgc gac cat gca gtg ttg atg gcc 739
Asp Leu Asn His Val Ala Arg Trp Cys Asp His Ala Val Leu Met Ala
200 205 210
gac ggc gaa gtt gtc tcc caa ggt gac atc cgc gag gtg ctc gaa cct 787
Asp Gly Glu Val Val Ser Gln Gly Asp Ile Arg Glu Val Leu Glu Pro
215 220 225
gcc aca ctg tcc acc gtg tac gga ctg ccc att gcg gtg cgc gat gat 835
Ala Thr Leu Ser Thr Val Tyr Gly Leu Pro Ile Ala Val Arg Asp Asp
230 235 240 245
ccc gaa acc agc tca ctt cgc gtg atc ccg cat cca aat ccc ttt 880
Pro Glu Thr Ser Ser Leu Arg Val Ile Pro His Pro Asn Pro Phe
250 255 260
tgattgaaag tttgacttaa aaa 903
<210> 392
<211> 260
<212> PRT
<213> Corynebacterium glutamicum
<400> 392
Met Pro Gln Leu Val Glu Ile Arg Asp Leu Asn Val Glu Phe Pro Ser
1 5 10 15
Arg His Ala Val Lys Asn Val Ser Phe Ser Ala Pro Ala Gly Lys Val
20 25 30
Thr Ala Leu Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Ala Leu Ser
35 40 45
Ala Ile Ala Gly Leu Val Glu Ser Thr Gly Glu Val Met Val Gly Gly
50 55 60
Ser Gly Val Ala Ser Lys Ser Ala Lys Ala Arg Ala Arg Leu Leu Ser
65 70 75 80
Leu Val Pro Gln Asn Thr Glu Leu Arg Ile Gly Phe Ser Ala Arg Asp
85 90 95
Val Val Ala Met Gly Arg Tyr Pro His Arg Gly Arg Phe Ala Val Glu
100 105 110
Thr Asp Ala Asp Arg Arg Ala Thr Asp Asp Ala Leu Arg Ala Ile Asn
115 120 125
Ala Leu Asp Ile Ala Glu Gln Pro Val Asn Glu Leu Ser Gly Gly Gln
130 135 140
Gln Gln Leu Ile His Ile Gly Arg Ala Leu Ala Gln Asp Thr Ala Val
145 150 155 160
Val Leu Leu Asp Glu Pro Val Ser Ala Leu Asp Leu Arg His Gln Val
165 170 175
Glu Val Leu Gln Leu Leu Arg Ala Arg Ala Asn Ser Gly Thr Thr Val
180 185 190
Ile Val Val Leu His Asp Leu Asn His Val Ala Arg Trp Cys Asp His
195 200 205
Ala Val Leu Met Ala Asp Gly Glu Val Val Ser Gln Gly Asp Ile Arg
210 215 220
Glu Val Leu Glu Pro Ala Thr Leu Ser Thr Val Tyr Gly Leu Pro Ile
225 230 235 240
Ala Val Arg Asp Asp Pro Glu Thr Ser Ser Leu Arg Val Ile Pro His
245 250 255
Pro Asn Pro Phe
260
<210> 393
<211> 582
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(559)
<223> RXN03081
<400> 393
acggactgcc cattgcggtg cgcgatgatc ccgaaaccag ctcacttcgc gtgatcccgc 60
atccaaatcc cttttgattg aaagtttgac ttaaaaaccc atg aaa aaa tca ctc 115
Met Lys Lys Ser Leu
1 5
atc gcc att gtt gcc agt gcg ctc gtg tta agc ggc tgc acc tct gat 163
Ile Ala Ile Val Ala Ser Ala Leu Val Leu Ser Gly Cys Thr Ser Asp
10 15 20
tct tct gac tct tcc ggc act tcc gga act gtg gaa acc act tcg att 211
Ser Ser Asp Ser Ser Gly Thr Ser Gly Thr Val Glu Thr Thr Ser Ile
25 30 35
aca acc agc gtt gcc gca gct gac ggc gca ttc cca cgc acc gtc aca 259
Thr Thr Ser Val Ala Ala Ala Asp Gly Ala Phe Pro Arg Thr Val Thr
40 45 50
ctc gac gat tcc tcc atc acc tta gaa tcc aaa cca gag cgc atc gcc 307
Leu Asp Asp Ser Ser Ile Thr Leu Glu Ser Lys Pro Glu Arg Ile Ala
55 60 65
gta ctc acc cca gag gca gca tcc ttg gtt ctc ccc atc aca ggc gcc 355
Val Leu Thr Pro Glu Ala Ala Ser Leu Val Leu Pro Ile Thr Gly Ala
70 75 80 85
gac cgc gtc gtg atg acc gcc gaa atg gac acc gct gac gaa gaa acc 403
Asp Arg Val Val Met Thr Ala Glu Met Asp Thr Ala Asp Glu Glu Thr
90 95 100
gca gct ctg gcc tcc caa gtg gaa tac caa gtc aaa aac ggt ggc agg 451
Ala Ala Leu Ala Ser Gln Val Glu Tyr Gln Val Lys Asn Gly Gly Arg
105 110 115
ctc gac ccc gaa caa gtt gtc gcc ggc gac cca gat ttg gtg atc gtc 499
Leu Asp Pro Glu Gln Val Val Ala Gly Asp Pro Asp Leu Val Ile Val
120 125 130
agt gcg cgt ttc gat acc gaa caa ggc acc atc gac att ttg gaa ggc 547
Ser Ala Arg Phe Asp Thr Glu Gln Gly Thr Ile Asp Ile Leu Glu Gly
135 140 145
ctc aac gtc ccg tagttaactt cgattcagac gct 582
Leu Asn Val Pro
150
<210> 394
<211> 153
<212> PRT
<213> Corynebacterium glutamicum
<400> 394
Met Lys Lys Ser Leu Ile Ala Ile Val Ala Ser Ala Leu Val Leu Ser
1 5 10 15
Gly Cys Thr Ser Asp Ser Ser Asp Ser Ser Gly Thr Ser Gly Thr Val
20 25 30
Glu Thr Thr Ser Ile Thr Thr Ser Val Ala Ala Ala Asp Gly Ala Phe
35 40 45
Pro Arg Thr Val Thr Leu Asp Asp Ser Ser Ile Thr Leu Glu Ser Lys
50 55 60
Pro Glu Arg Ile Ala Val Leu Thr Pro Glu Ala Ala Ser Leu Val Leu
65 70 75 80
Pro Ile Thr Gly Ala Asp Arg Val Val Met Thr Ala Glu Met Asp Thr
85 90 95
Ala Asp Glu Glu Thr Ala Ala Leu Ala Ser Gln Val Glu Tyr Gln Val
100 105 110
Lys Asn Gly Gly Arg Leu Asp Pro Glu Gln Val Val Ala Gly Asp Pro
115 120 125
Asp Leu Val Ile Val Ser Ala Arg Phe Asp Thr Glu Gln Gly Thr Ile
130 135 140
Asp Ile Leu Glu Gly Leu Asn Val Pro
145 150
<210> 395
<211> 444
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(421)
<223> RXN03082
<400> 395
cagaagcaat cgcagaaatc gatgcaaacc gcattcgaca ttcgacaagc ctgccacctc 60
ccccactgtg ctcactttga tgcaacgcgg accacgccaa atg gtc atg cca gaa 115
Met Val Met Pro Glu
1 5
tct gcc atg ctc acc ggc ctg atc cgc gaa gcc ggc ggc act cca gtg 163
Ser Ala Met Leu Thr Gly Leu Ile Arg Glu Ala Gly Gly Thr Pro Val
10 15 20
gta gat tct ctc ggc gcg gta ggc acc atc act gca gac cca gaa caa 211
Val Asp Ser Leu Gly Ala Val Gly Thr Ile Thr Ala Asp Pro Glu Gln
25 30 35
gtt gtt gcg atg gca cct gag atc atc atc att cag gac ttc caa ggt 259
Val Val Ala Met Ala Pro Glu Ile Ile Ile Ile Gln Asp Phe Gln Gly
40 45 50
aaa ggc cga gag aac ttc gct aat ttc ctc tcc aac cca gcg cta gcc 307
Lys Gly Arg Glu Asn Phe Ala Asn Phe Leu Ser Asn Pro Ala Leu Ala
55 60 65
aac gtt ccc gcc att gaa aac gac aag att ttc tac gcc gac act gtc 355
Asn Val Pro Ala Ile Glu Asn Asp Lys Ile Phe Tyr Ala Asp Thr Val
70 75 80 85
acc act gga gtt act gca ggt acc gat atc acc act ggt ctg cag caa 403
Thr Thr Gly Val Thr Ala Gly Thr Asp Ile Thr Thr Gly Leu Gln Gln
90 95 100
gtg gca gaa atg ctg agc tagttttgag atgttgaaac tag 444
Val Ala Glu Met Leu Ser
105
<210> 396
<211> 107
<212> PRT
<213> Corynebacterium glutamicum
<400> 396
Met Val Met Pro Glu Ser Ala Met Leu Thr Gly Leu Ile Arg Glu Ala
1 5 10 15
Gly Gly Thr Pro Val Val Asp Ser Leu Gly Ala Val Gly Thr Ile Thr
20 25 30
Ala Asp Pro Glu Gln Val Val Ala Met Ala Pro Glu Ile Ile Ile Ile
35 40 45
Gln Asp Phe Gln Gly Lys Gly Arg Glu Asn Phe Ala Asn Phe Leu Ser
50 55 60
Asn Pro Ala Leu Ala Asn Val Pro Ala Ile Glu Asn Asp Lys Ile Phe
65 70 75 80
Tyr Ala Asp Thr Val Thr Thr Gly Val Thr Ala Gly Thr Asp Ile Thr
85 90 95
Thr Gly Leu Gln Gln Val Ala Glu Met Leu Ser
100 105
<210> 397
<211> 1479
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1456)
<223> RXA02261
<400> 397
gaaatctata gaacgatagg taaaaactgg actaggttta tctatagcgg aatagaaaat 60
actccgctcg acagcatcac ttagctgaaa ggcctttaac atg gac ccc tca gat 115
Met Asp Pro Ser Asp
1 5
cta gcc tgg att ctc gca gct ttt gcg ttg gta agc ctg atg ttc ccc 163
Leu Ala Trp Ile Leu Ala Ala Phe Ala Leu Val Ser Leu Met Phe Pro
10 15 20
gga ttg tcc ctg ctc tac ggc ggc atg ctg ggt ggg caa cac gtt ctt 211
Gly Leu Ser Leu Leu Tyr Gly Gly Met Leu Gly Gly Gln His Val Leu
25 30 35
aac acg ttc atg atg gtt atg agc tca ctt gga atc atc agc ctt gtg 259
Asn Thr Phe Met Met Val Met Ser Ser Leu Gly Ile Ile Ser Leu Val
40 45 50
tac atc att tat gga cac gga ctt gtc tta gga aac tcc atc ggt ggg 307
Tyr Ile Ile Tyr Gly His Gly Leu Val Leu Gly Asn Ser Ile Gly Gly
55 60 65
tgg gga att atc gga aat ccc ctt gaa tac ttc ggc ttc cgc aac att 355
Trp Gly Ile Ile Gly Asn Pro Leu Glu Tyr Phe Gly Phe Arg Asn Ile
70 75 80 85
atg gaa gat gac ggc acc gga gac ctc atg tgg gcc ggc ttc tac att 403
Met Glu Asp Asp Gly Thr Gly Asp Leu Met Trp Ala Gly Phe Tyr Ile
90 95 100
ctg ttc gct gca atc tca ctc gca ctt gtt tca tct ggt gca gcg ggg 451
Leu Phe Ala Ala Ile Ser Leu Ala Leu Val Ser Ser Gly Ala Ala Gly
105 110 115
cgc atg cgc ttt gga gcg tgg ctg gtc ttc ggt gtc ctg tgg ttc acc 499
Arg Met Arg Phe Gly Ala Trp Leu Val Phe Gly Val Leu Trp Phe Thr
120 125 130
ttt gtg tac gcg cca ctg gca cac tgg gtt ttc gct atc gat gat cct 547
Phe Val Tyr Ala Pro Leu Ala His Trp Val Phe Ala Ile Asp Asp Pro
135 140 145
gag tcc ggc tac gtg ggt ggc tgg atg aaa aat gtg ctt gag ttc cac 595
Glu Ser Gly Tyr Val Gly Gly Trp Met Lys Asn Val Leu Glu Phe His
150 155 160 165
gac ttt gct ggt gga acg gca gtg cac atg aat gcg ggt gcg tct gga 643
Asp Phe Ala Gly Gly Thr Ala Val His Met Asn Ala Gly Ala Ser Gly
170 175 180
ctc gcg ctg gca ata gtg ctg gga cgc cgc cac tcc atg gct gtg cgt 691
Leu Ala Leu Ala Ile Val Leu Gly Arg Arg His Ser Met Ala Val Arg
185 190 195
cca cac aac ctt cca ctg att ttg att ggt gca gga ctg atc gtt gcg 739
Pro His Asn Leu Pro Leu Ile Leu Ile Gly Ala Gly Leu Ile Val Ala
200 205 210
ggc tgg ttc gga ttc aat ggt ggt acc gca ggt ggt gcc aac ttc ctc 787
Gly Trp Phe Gly Phe Asn Gly Gly Thr Ala Gly Gly Ala Asn Phe Leu
215 220 225
gca agc tac gtg gtc gtt acc tct ctc att gct gca gct ggc gga atg 835
Ala Ser Tyr Val Val Val Thr Ser Leu Ile Ala Ala Ala Gly Gly Met
230 235 240 245
atg ggc ttc atg ctc gtt gaa cgt gtg ttc agc gga aaa ccc act ttc 883
Met Gly Phe Met Leu Val Glu Arg Val Phe Ser Gly Lys Pro Thr Phe
250 255 260
ttt ggc tcg gca acc ggc aca atc gca ggc ctt gtg gct atc acc ccg 931
Phe Gly Ser Ala Thr Gly Thr Ile Ala Gly Leu Val Ala Ile Thr Pro
265 270 275
gcc gcg gat gca gtg agc ccg ctc gga gca ttc gcc gtc gga gcg ctc 979
Ala Ala Asp Ala Val Ser Pro Leu Gly Ala Phe Ala Val Gly Ala Leu
280 285 290
ggc gca gtt gtc tcc ttc tgg gca att agc tgg aag aag gga cac cga 1027
Gly Ala Val Val Ser Phe Trp Ala Ile Ser Trp Lys Lys Gly His Arg
295 300 305
gtc gat gat tcc ttc gat gtg ttc gca gtc cac gga atg gcc ggc att 1075
Val Asp Asp Ser Phe Asp Val Phe Ala Val His Gly Met Ala Gly Ile
310 315 320 325
gca ggt gca ctg ttt gtc atg ctc ttt ggc gat cca cta gca cca gcg 1123
Ala Gly Ala Leu Phe Val Met Leu Phe Gly Asp Pro Leu Ala Pro Ala
330 335 340
gga gtt tcc gga gtc ttc ttc ggt ggc gaa ctc tcc ctg ctg tgg agg 1171
Gly Val Ser Gly Val Phe Phe Gly Gly Glu Leu Ser Leu Leu Trp Arg
345 350 355
gaa cca ctg gcc atc atc gtg acc ctt aca tac gca ttc ggc gtg acc 1219
Glu Pro Leu Ala Ile Ile Val Thr Leu Thr Tyr Ala Phe Gly Val Thr
360 365 370
tgg ttg att gcc acg atc ttg aac aag ttc atg act ctg cgc atc acc 1267
Trp Leu Ile Ala Thr Ile Leu Asn Lys Phe Met Thr Leu Arg Ile Thr
375 380 385
tcc gaa gcc gaa tat gaa ggc att gac cgc gca gaa cac gca gaa tct 1315
Ser Glu Ala Glu Tyr Glu Gly Ile Asp Arg Ala Glu His Ala Glu Ser
390 395 400 405
gcc tac cac ctc aat tcc aac gga att ggg atg gca acc cgc acc aat 1363
Ala Tyr His Leu Asn Ser Asn Gly Ile Gly Met Ala Thr Arg Thr Asn
410 415 420
ttc gga cct gaa atc ccc gag gaa acc gtg ccc gac gcc gtg cag gtg 1411
Phe Gly Pro Glu Ile Pro Glu Glu Thr Val Pro Asp Ala Val Gln Val
425 430 435
ggc gtc gat aag caa aaa atc gct gat act cga aag gcc tca aaa 1456
Gly Val Asp Lys Gln Lys Ile Ala Asp Thr Arg Lys Ala Ser Lys
440 445 450
tgaccgcaac ctacaccact gaa 1479
<210> 398
<211> 452
<212> PRT
<213> Corynebacterium glutamicum
<400> 398
Met Asp Pro Ser Asp Leu Ala Trp Ile Leu Ala Ala Phe Ala Leu Val
1 5 10 15
Ser Leu Met Phe Pro Gly Leu Ser Leu Leu Tyr Gly Gly Met Leu Gly
20 25 30
Gly Gln His Val Leu Asn Thr Phe Met Met Val Met Ser Ser Leu Gly
35 40 45
Ile Ile Ser Leu Val Tyr Ile Ile Tyr Gly His Gly Leu Val Leu Gly
50 55 60
Asn Ser Ile Gly Gly Trp Gly Ile Ile Gly Asn Pro Leu Glu Tyr Phe
65 70 75 80
Gly Phe Arg Asn Ile Met Glu Asp Asp Gly Thr Gly Asp Leu Met Trp
85 90 95
Ala Gly Phe Tyr Ile Leu Phe Ala Ala Ile Ser Leu Ala Leu Val Ser
100 105 110
Ser Gly Ala Ala Gly Arg Met Arg Phe Gly Ala Trp Leu Val Phe Gly
115 120 125
Val Leu Trp Phe Thr Phe Val Tyr Ala Pro Leu Ala His Trp Val Phe
130 135 140
Ala Ile Asp Asp Pro Glu Ser Gly Tyr Val Gly Gly Trp Met Lys Asn
145 150 155 160
Val Leu Glu Phe His Asp Phe Ala Gly Gly Thr Ala Val His Met Asn
165 170 175
Ala Gly Ala Ser Gly Leu Ala Leu Ala Ile Val Leu Gly Arg Arg His
180 185 190
Ser Met Ala Val Arg Pro His Asn Leu Pro Leu Ile Leu Ile Gly Ala
195 200 205
Gly Leu Ile Val Ala Gly Trp Phe Gly Phe Asn Gly Gly Thr Ala Gly
210 215 220
Gly Ala Asn Phe Leu Ala Ser Tyr Val Val Val Thr Ser Leu Ile Ala
225 230 235 240
Ala Ala Gly Gly Met Met Gly Phe Met Leu Val Glu Arg Val Phe Ser
245 250 255
Gly Lys Pro Thr Phe Phe Gly Ser Ala Thr Gly Thr Ile Ala Gly Leu
260 265 270
Val Ala Ile Thr Pro Ala Ala Asp Ala Val Ser Pro Leu Gly Ala Phe
275 280 285
Ala Val Gly Ala Leu Gly Ala Val Val Ser Phe Trp Ala Ile Ser Trp
290 295 300
Lys Lys Gly His Arg Val Asp Asp Ser Phe Asp Val Phe Ala Val His
305 310 315 320
Gly Met Ala Gly Ile Ala Gly Ala Leu Phe Val Met Leu Phe Gly Asp
325 330 335
Pro Leu Ala Pro Ala Gly Val Ser Gly Val Phe Phe Gly Gly Glu Leu
340 345 350
Ser Leu Leu Trp Arg Glu Pro Leu Ala Ile Ile Val Thr Leu Thr Tyr
355 360 365
Ala Phe Gly Val Thr Trp Leu Ile Ala Thr Ile Leu Asn Lys Phe Met
370 375 380
Thr Leu Arg Ile Thr Ser Glu Ala Glu Tyr Glu Gly Ile Asp Arg Ala
385 390 395 400
Glu His Ala Glu Ser Ala Tyr His Leu Asn Ser Asn Gly Ile Gly Met
405 410 415
Ala Thr Arg Thr Asn Phe Gly Pro Glu Ile Pro Glu Glu Thr Val Pro
420 425 430
Asp Ala Val Gln Val Gly Val Asp Lys Gln Lys Ile Ala Asp Thr Arg
435 440 445
Lys Ala Ser Lys
450
<210> 399
<211> 1111
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1111)
<223> RXA02020
<400> 399
ttggtcaatc aagcgtgaat ccggcttcca tgagccagtt gcccgcctca aagcttgacc 60
cattttcata accagtgcca tgtgggttta cggttgatac atg gct aaa tct aat 115
Met Ala Lys Ser Asn
1 5
gaa ggg ctg gga acc gga ctt cgg acc cgc cac ctc aca atg atg gga 163
Glu Gly Leu Gly Thr Gly Leu Arg Thr Arg His Leu Thr Met Met Gly
10 15 20
ctc ggc tcc gca att ggt gcc gga ctg ttc ctc ggc acc ggc gtt ggt 211
Leu Gly Ser Ala Ile Gly Ala Gly Leu Phe Leu Gly Thr Gly Val Gly
25 30 35
atc cgc gca gcc ggc ccc gca gtg ctc ctg gcg tac atc atc gcc gga 259
Ile Arg Ala Ala Gly Pro Ala Val Leu Leu Ala Tyr Ile Ile Ala Gly
40 45 50
gcc atc gtt gtg ctt gtt atg caa atg ctc ggc gag atg gct gct gcc 307
Ala Ile Val Val Leu Val Met Gln Met Leu Gly Glu Met Ala Ala Ala
55 60 65
cgt ccc gcc tcc gga tcg ttt tca cgt tac ggc gag gat gct ttc ggc 355
Arg Pro Ala Ser Gly Ser Phe Ser Arg Tyr Gly Glu Asp Ala Phe Gly
70 75 80 85
cac tgg gct ggt ttc tcc ctc ggt tgg ttg tac tgg ttc atg ctg att 403
His Trp Ala Gly Phe Ser Leu Gly Trp Leu Tyr Trp Phe Met Leu Ile
90 95 100
atg gtg atg ggc gcc gaa atg act ggc gct gct gcc atc atg ggt gca 451
Met Val Met Gly Ala Glu Met Thr Gly Ala Ala Ala Ile Met Gly Ala
105 110 115
tgg ttc ggc gtc gaa ccg tgg att cct tcg ctt gtc tgc gtg gtc ttc 499
Trp Phe Gly Val Glu Pro Trp Ile Pro Ser Leu Val Cys Val Val Phe
120 125 130
ttc gct gtg gtg aac ctc gtc gcg gtt cgc ggt ttc ggt gaa ttc gag 547
Phe Ala Val Val Asn Leu Val Ala Val Arg Gly Phe Gly Glu Phe Glu
135 140 145
tac tgg ttc gca ttc att aag gtc gcg gtg atc atc gct ttc ctc atc 595
Tyr Trp Phe Ala Phe Ile Lys Val Ala Val Ile Ile Ala Phe Leu Ile
150 155 160 165
att ggt att gct ctt att ttc gga tgg ctt ccc gga tcc acc ttt gtt 643
Ile Gly Ile Ala Leu Ile Phe Gly Trp Leu Pro Gly Ser Thr Phe Val
170 175 180
gga acc tca aac ttc atc ggt gat cac gga ttc atg ccc aat ggt att 691
Gly Thr Ser Asn Phe Ile Gly Asp His Gly Phe Met Pro Asn Gly Ile
185 190 195
tct ggt gtt gct gct ggt ttg ctc gcg gtg gct ttt gcc ttt ggt ggc 739
Ser Gly Val Ala Ala Gly Leu Leu Ala Val Ala Phe Ala Phe Gly Gly
200 205 210
att gaa att gtc acc att gca gct gca gag tcc gat aag cca cgt gaa 787
Ile Glu Ile Val Thr Ile Ala Ala Ala Glu Ser Asp Lys Pro Arg Glu
215 220 225
gct att tcc ctg gcg gtg cgt gcc gtg att tgg cgt att tca gtc ttt 835
Ala Ile Ser Leu Ala Val Arg Ala Val Ile Trp Arg Ile Ser Val Phe
230 235 240 245
tac ttg ggc tct gtt ttg gtc atc act ttc ctc atg cct tat gag tcg 883
Tyr Leu Gly Ser Val Leu Val Ile Thr Phe Leu Met Pro Tyr Glu Ser
250 255 260
atc aat ggt gcc gac acc gct gcg gaa tcc ccc ttc acc caa atc ctg 931
Ile Asn Gly Ala Asp Thr Ala Ala Glu Ser Pro Phe Thr Gln Ile Leu
265 270 275
gcg atg gca aac atc cct ggc acg gtt ggt ttc atg gaa gcg atc atc 979
Ala Met Ala Asn Ile Pro Gly Thr Val Gly Phe Met Glu Ala Ile Ile
280 285 290
gtt cta gca ctg ctt tcc gct ttc aac gcc caa atc tat gcc act tct 1027
Val Leu Ala Leu Leu Ser Ala Phe Asn Ala Gln Ile Tyr Ala Thr Ser
295 300 305
cgt ttg gta ttt tcc atg gcg aat cga caa gac gct ccg cga gtt ttc 1075
Arg Leu Val Phe Ser Met Ala Asn Arg Gln Asp Ala Pro Arg Val Phe
310 315 320 325
agt aag ctc agc acc agc cac gtc ccc acc aat gcg 1111
Ser Lys Leu Ser Thr Ser His Val Pro Thr Asn Ala
330 335
<210> 400
<211> 337
<212> PRT
<213> Corynebacterium glutamicum
<400> 400
Met Ala Lys Ser Asn Glu Gly Leu Gly Thr Gly Leu Arg Thr Arg His
1 5 10 15
Leu Thr Met Met Gly Leu Gly Ser Ala Ile Gly Ala Gly Leu Phe Leu
20 25 30
Gly Thr Gly Val Gly Ile Arg Ala Ala Gly Pro Ala Val Leu Leu Ala
35 40 45
Tyr Ile Ile Ala Gly Ala Ile Val Val Leu Val Met Gln Met Leu Gly
50 55 60
Glu Met Ala Ala Ala Arg Pro Ala Ser Gly Ser Phe Ser Arg Tyr Gly
65 70 75 80
Glu Asp Ala Phe Gly His Trp Ala Gly Phe Ser Leu Gly Trp Leu Tyr
85 90 95
Trp Phe Met Leu Ile Met Val Met Gly Ala Glu Met Thr Gly Ala Ala
100 105 110
Ala Ile Met Gly Ala Trp Phe Gly Val Glu Pro Trp Ile Pro Ser Leu
115 120 125
Val Cys Val Val Phe Phe Ala Val Val Asn Leu Val Ala Val Arg Gly
130 135 140
Phe Gly Glu Phe Glu Tyr Trp Phe Ala Phe Ile Lys Val Ala Val Ile
145 150 155 160
Ile Ala Phe Leu Ile Ile Gly Ile Ala Leu Ile Phe Gly Trp Leu Pro
165 170 175
Gly Ser Thr Phe Val Gly Thr Ser Asn Phe Ile Gly Asp His Gly Phe
180 185 190
Met Pro Asn Gly Ile Ser Gly Val Ala Ala Gly Leu Leu Ala Val Ala
195 200 205
Phe Ala Phe Gly Gly Ile Glu Ile Val Thr Ile Ala Ala Ala Glu Ser
210 215 220
Asp Lys Pro Arg Glu Ala Ile Ser Leu Ala Val Arg Ala Val Ile Trp
225 230 235 240
Arg Ile Ser Val Phe Tyr Leu Gly Ser Val Leu Val Ile Thr Phe Leu
245 250 255
Met Pro Tyr Glu Ser Ile Asn Gly Ala Asp Thr Ala Ala Glu Ser Pro
260 265 270
Phe Thr Gln Ile Leu Ala Met Ala Asn Ile Pro Gly Thr Val Gly Phe
275 280 285
Met Glu Ala Ile Ile Val Leu Ala Leu Leu Ser Ala Phe Asn Ala Gln
290 295 300
Ile Tyr Ala Thr Ser Arg Leu Val Phe Ser Met Ala Asn Arg Gln Asp
305 310 315 320
Ala Pro Arg Val Phe Ser Lys Leu Ser Thr Ser His Val Pro Thr Asn
325 330 335
Ala
<210> 401
<211> 784
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(784)
<223> RXA00281
<400> 401
ggttgactct ttggctttga tgccagcatt cgccaaagcg tggccctctt taagaaagct 60
actgaacaca acagagtagg tttatgcgac actggtgcgc atg atc aac gtt gaa 115
Met Ile Asn Val Glu
1 5
ggc ctc acc aaa caa tat ggt cag gtc cgc gca gtc gat gat ctg agc 163
Gly Leu Thr Lys Gln Tyr Gly Gln Val Arg Ala Val Asp Asp Leu Ser
10 15 20
ttc gaa gta aaa ccc gga ata gtc acc gga ttt ctc ggc ccc aac ggc 211
Phe Glu Val Lys Pro Gly Ile Val Thr Gly Phe Leu Gly Pro Asn Gly
25 30 35
gcc gga aaa tcc acc acg atg cgg ctg atc ctt ggc tta gat aat cca 259
Ala Gly Lys Ser Thr Thr Met Arg Leu Ile Leu Gly Leu Asp Asn Pro
40 45 50
act gca ggg cat gcc acg atc gaa gga caa ccc tac cga tcg ctc aaa 307
Thr Ala Gly His Ala Thr Ile Glu Gly Gln Pro Tyr Arg Ser Leu Lys
55 60 65
aat ccc ctg acc aaa gtg gga gca ctg ctt gat gcc aaa gca aca cac 355
Asn Pro Leu Thr Lys Val Gly Ala Leu Leu Asp Ala Lys Ala Thr His
70 75 80 85
cca aat aga aca gca gaa aac cac ctc aag tgg atc gcc cgt gca aat 403
Pro Asn Arg Thr Ala Glu Asn His Leu Lys Trp Ile Ala Arg Ala Asn
90 95 100
ggg ctg tcc acc aaa aga gtc gat gaa gtt ctc acc ctc gtg gga ctg 451
Gly Leu Ser Thr Lys Arg Val Asp Glu Val Leu Thr Leu Val Gly Leu
105 110 115
act ggt gtt ggg tca aag aag acc ggt ggg ttt tca cta ggc atg ggc 499
Thr Gly Val Gly Ser Lys Lys Thr Gly Gly Phe Ser Leu Gly Met Gly
120 125 130
caa cgt cta gga ctt gct gca gca ttg ctc ggc gat ccg gaa tac tta 547
Gln Arg Leu Gly Leu Ala Ala Ala Leu Leu Gly Asp Pro Glu Tyr Leu
135 140 145
att ctc gac gaa ccc gtc aac ggc ctt gac cca gaa ggc att cac tgg 595
Ile Leu Asp Glu Pro Val Asn Gly Leu Asp Pro Glu Gly Ile His Trp
150 155 160 165
gtg cgc acc ttg ttg caa aac atc gcc aag cag ggc aga acc gtg ctc 643
Val Arg Thr Leu Leu Gln Asn Ile Ala Lys Gln Gly Arg Thr Val Leu
170 175 180
gtg agt tcc cac ctg ctg tcc gag atg gcg caa act gcg gaa cat ttg 691
Val Ser Ser His Leu Leu Ser Glu Met Ala Gln Thr Ala Glu His Leu
185 190 195
atc gtg att ggg cgt ggc aag ctg gtc gcc gat atg ccc atg cat gag 739
Ile Val Ile Gly Arg Gly Lys Leu Val Ala Asp Met Pro Met His Glu
200 205 210
ttt gtg cgc tcc cat tcc gct tcc aca gtt gtg gtg cgg gca gca 784
Phe Val Arg Ser His Ser Ala Ser Thr Val Val Val Arg Ala Ala
215 220 225
<210> 402
<211> 228
<212> PRT
<213> Corynebacterium glutamicum
<400> 402
Met Ile Asn Val Glu Gly Leu Thr Lys Gln Tyr Gly Gln Val Arg Ala
1 5 10 15
Val Asp Asp Leu Ser Phe Glu Val Lys Pro Gly Ile Val Thr Gly Phe
20 25 30
Leu Gly Pro Asn Gly Ala Gly Lys Ser Thr Thr Met Arg Leu Ile Leu
35 40 45
Gly Leu Asp Asn Pro Thr Ala Gly His Ala Thr Ile Glu Gly Gln Pro
50 55 60
Tyr Arg Ser Leu Lys Asn Pro Leu Thr Lys Val Gly Ala Leu Leu Asp
65 70 75 80
Ala Lys Ala Thr His Pro Asn Arg Thr Ala Glu Asn His Leu Lys Trp
85 90 95
Ile Ala Arg Ala Asn Gly Leu Ser Thr Lys Arg Val Asp Glu Val Leu
100 105 110
Thr Leu Val Gly Leu Thr Gly Val Gly Ser Lys Lys Thr Gly Gly Phe
115 120 125
Ser Leu Gly Met Gly Gln Arg Leu Gly Leu Ala Ala Ala Leu Leu Gly
130 135 140
Asp Pro Glu Tyr Leu Ile Leu Asp Glu Pro Val Asn Gly Leu Asp Pro
145 150 155 160
Glu Gly Ile His Trp Val Arg Thr Leu Leu Gln Asn Ile Ala Lys Gln
165 170 175
Gly Arg Thr Val Leu Val Ser Ser His Leu Leu Ser Glu Met Ala Gln
180 185 190
Thr Ala Glu His Leu Ile Val Ile Gly Arg Gly Lys Leu Val Ala Asp
195 200 205
Met Pro Met His Glu Phe Val Arg Ser His Ser Ala Ser Thr Val Val
210 215 220
Val Arg Ala Ala
225
<210> 403
<211> 852
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(852)
<223> RXN00570
<400> 403
acg aga cct cgg ccc caa gaa att ggc aac ggg ctt gtc gca ctg att 48
Thr Arg Pro Arg Pro Gln Glu Ile Gly Asn Gly Leu Val Ala Leu Ile
1 5 10 15
ttc tcc gca tcc gga ccc atc gca gtg atc ctg gct gct gct gca gcg 96
Phe Ser Ala Ser Gly Pro Ile Ala Val Ile Leu Ala Ala Ala Ala Ala
20 25 30
gga aac ctt tcg cct gat caa aca tct tca tgg atc ttc gga gca ttt 144
Gly Asn Leu Ser Pro Asp Gln Thr Ser Ser Trp Ile Phe Gly Ala Phe
35 40 45
tta ggc aac gga ctg ctc acg ctg tgg ctt acc tat atg tac cgc agc 192
Leu Gly Asn Gly Leu Leu Thr Leu Trp Leu Thr Tyr Met Tyr Arg Ser
50 55 60
ccg cag gca tac ttc tgg acg att ccc gga acc gtc atc gtg ggc gac 240
Pro Gln Ala Tyr Phe Trp Thr Ile Pro Gly Thr Val Ile Val Gly Asp
65 70 75 80
tca ctt acc cac tta agt ttc gct gaa gtt atc ggc gca tac ctt gtt 288
Ser Leu Thr His Leu Ser Phe Ala Glu Val Ile Gly Ala Tyr Leu Val
85 90 95
acc ggc gtt gtg gtg ttt gcg ctc gga tgg acc ggt ctc atc gga cgg 336
Thr Gly Val Val Val Phe Ala Leu Gly Trp Thr Gly Leu Ile Gly Arg
100 105 110
atc atg gcg gta ctg cca cca acc atc gtg atg gcc atg gtc gca ggc 384
Ile Met Ala Val Leu Pro Pro Thr Ile Val Met Ala Met Val Ala Gly
115 120 125
att ttc ctc cgc ttc gga ctc gac ctc atc gac gcc agc gtg acc gac 432
Ile Phe Leu Arg Phe Gly Leu Asp Leu Ile Asp Ala Ser Val Thr Asp
130 135 140
ccg ctc att gca ctt ccc atg gtc ata gtt ttt gtg gca ttg agc atg 480
Pro Leu Ile Ala Leu Pro Met Val Ile Val Phe Val Ala Leu Ser Met
145 150 155 160
agt ccc cgc ttg gca agc atc gcc cca ccc gtt gca gta gcc gca gta 528
Ser Pro Arg Leu Ala Ser Ile Ala Pro Pro Val Ala Val Ala Ala Val
165 170 175
gtg gga acc atc gtt gcc atc gca tcc ggc aaa cta gcg tcc gga att 576
Val Gly Thr Ile Val Ala Ile Ala Ser Gly Lys Leu Ala Ser Gly Ile
180 185 190
cta gac aac gga att atc tcc cgc ccc gtc ttt acc gcc cca gaa ttt 624
Leu Asp Asn Gly Ile Ile Ser Arg Pro Val Phe Thr Ala Pro Glu Phe
195 200 205
tcc ttc gcc gcc atc atg gaa ctc gtt gtt ccc ttg gcg atc acc gta 672
Ser Phe Ala Ala Ile Met Glu Leu Val Val Pro Leu Ala Ile Thr Val
210 215 220
gtc att gtc caa aac ggc caa ggc gtc gca gtg ctt aaa gca gca ggt 720
Val Ile Val Gln Asn Gly Gln Gly Val Ala Val Leu Lys Ala Ala Gly
225 230 235 240
cac cgc ccc gga gta aac ctt gcc gcc gcg gcc tcc gga ctg tgg tcc 768
His Arg Pro Gly Val Asn Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser
245 250 255
cta ccc atg gcg ttg atc ggc aac atc acc acc tgc ctc acc ggc ccc 816
Leu Pro Met Ala Leu Ile Gly Asn Ile Thr Thr Cys Leu Thr Gly Pro
260 265 270
acc aac gcg ctg atc gtc gcc gga gca aaa tca cac 852
Thr Asn Ala Leu Ile Val Ala Gly Ala Lys Ser His
275 280
<210> 404
<211> 284
<212> PRT
<213> Corynebacterium glutamicum
<400> 404
Thr Arg Pro Arg Pro Gln Glu Ile Gly Asn Gly Leu Val Ala Leu Ile
1 5 10 15
Phe Ser Ala Ser Gly Pro Ile Ala Val Ile Leu Ala Ala Ala Ala Ala
20 25 30
Gly Asn Leu Ser Pro Asp Gln Thr Ser Ser Trp Ile Phe Gly Ala Phe
35 40 45
Leu Gly Asn Gly Leu Leu Thr Leu Trp Leu Thr Tyr Met Tyr Arg Ser
50 55 60
Pro Gln Ala Tyr Phe Trp Thr Ile Pro Gly Thr Val Ile Val Gly Asp
65 70 75 80
Ser Leu Thr His Leu Ser Phe Ala Glu Val Ile Gly Ala Tyr Leu Val
85 90 95
Thr Gly Val Val Val Phe Ala Leu Gly Trp Thr Gly Leu Ile Gly Arg
100 105 110
Ile Met Ala Val Leu Pro Pro Thr Ile Val Met Ala Met Val Ala Gly
115 120 125
Ile Phe Leu Arg Phe Gly Leu Asp Leu Ile Asp Ala Ser Val Thr Asp
130 135 140
Pro Leu Ile Ala Leu Pro Met Val Ile Val Phe Val Ala Leu Ser Met
145 150 155 160
Ser Pro Arg Leu Ala Ser Ile Ala Pro Pro Val Ala Val Ala Ala Val
165 170 175
Val Gly Thr Ile Val Ala Ile Ala Ser Gly Lys Leu Ala Ser Gly Ile
180 185 190
Leu Asp Asn Gly Ile Ile Ser Arg Pro Val Phe Thr Ala Pro Glu Phe
195 200 205
Ser Phe Ala Ala Ile Met Glu Leu Val Val Pro Leu Ala Ile Thr Val
210 215 220
Val Ile Val Gln Asn Gly Gln Gly Val Ala Val Leu Lys Ala Ala Gly
225 230 235 240
His Arg Pro Gly Val Asn Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser
245 250 255
Leu Pro Met Ala Leu Ile Gly Asn Ile Thr Thr Cys Leu Thr Gly Pro
260 265 270
Thr Asn Ala Leu Ile Val Ala Gly Ala Lys Ser His
275 280
<210> 405
<211> 498
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(498)
<223> FRXA00570
<400> 405
cca acc atc gtg atg gcc atg gtc gca ggc att ttc ctc cgc ttc gga 48
Pro Thr Ile Val Met Ala Met Val Ala Gly Ile Phe Leu Arg Phe Gly
1 5 10 15
ctc gac ctc atc gac gcc agc gtg acc gac ccg ctc att gca ctt ccc 96
Leu Asp Leu Ile Asp Ala Ser Val Thr Asp Pro Leu Ile Ala Leu Pro
20 25 30
atg gtc ata gtt ttt gtg gca ttg agc atg agt ccc cgc ttg gca agc 144
Met Val Ile Val Phe Val Ala Leu Ser Met Ser Pro Arg Leu Ala Ser
35 40 45
atc gcc cca ccc gtt gca gta gcc gca gta gtg gga acc atc gtt gcc 192
Ile Ala Pro Pro Val Ala Val Ala Ala Val Val Gly Thr Ile Val Ala
50 55 60
atc gca tcc ggc aaa cta gcg tcc gga att cta gac aac gga att atc 240
Ile Ala Ser Gly Lys Leu Ala Ser Gly Ile Leu Asp Asn Gly Ile Ile
65 70 75 80
tcc cgc ccc gtc ttt acc gcc cca gaa ttt tcc ttc gcc gcc atc atg 288
Ser Arg Pro Val Phe Thr Ala Pro Glu Phe Ser Phe Ala Ala Ile Met
85 90 95
gaa ctc gtt gtt ccc ttg gcg atc acc gta gtc att gtc caa aac ggc 336
Glu Leu Val Val Pro Leu Ala Ile Thr Val Val Ile Val Gln Asn Gly
100 105 110
caa ggc gtc gca gtg ctt aaa gca gca ggt cac cgc ccc gga gta aac 384
Gln Gly Val Ala Val Leu Lys Ala Ala Gly His Arg Pro Gly Val Asn
115 120 125
ctt gcc gcc gcg gcc tcc gga ctg tgg tcc cta ccc atg gcg ttg atc 432
Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser Leu Pro Met Ala Leu Ile
130 135 140
ggc aac atc acc acc tgc ctc acc ggc ccc acc aac gcg ctg atc gtc 480
Gly Asn Ile Thr Thr Cys Leu Thr Gly Pro Thr Asn Ala Leu Ile Val
145 150 155 160
gcc gga gca aaa tca cac 498
Ala Gly Ala Lys Ser His
165
<210> 406
<211> 166
<212> PRT
<213> Corynebacterium glutamicum
<400> 406
Pro Thr Ile Val Met Ala Met Val Ala Gly Ile Phe Leu Arg Phe Gly
1 5 10 15
Leu Asp Leu Ile Asp Ala Ser Val Thr Asp Pro Leu Ile Ala Leu Pro
20 25 30
Met Val Ile Val Phe Val Ala Leu Ser Met Ser Pro Arg Leu Ala Ser
35 40 45
Ile Ala Pro Pro Val Ala Val Ala Ala Val Val Gly Thr Ile Val Ala
50 55 60
Ile Ala Ser Gly Lys Leu Ala Ser Gly Ile Leu Asp Asn Gly Ile Ile
65 70 75 80
Ser Arg Pro Val Phe Thr Ala Pro Glu Phe Ser Phe Ala Ala Ile Met
85 90 95
Glu Leu Val Val Pro Leu Ala Ile Thr Val Val Ile Val Gln Asn Gly
100 105 110
Gln Gly Val Ala Val Leu Lys Ala Ala Gly His Arg Pro Gly Val Asn
115 120 125
Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser Leu Pro Met Ala Leu Ile
130 135 140
Gly Asn Ile Thr Thr Cys Leu Thr Gly Pro Thr Asn Ala Leu Ile Val
145 150 155 160
Ala Gly Ala Lys Ser His
165
<210> 407
<211> 1280
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(1257)
<223> RXN00571
<400> 407
aca ctt gtt cca cag gtt tac gaa ata gtg atc tac ggc gct gtg ctg 48
Thr Leu Val Pro Gln Val Tyr Glu Ile Val Ile Tyr Gly Ala Val Leu
1 5 10 15
tca gct gta cat gaa gat cca acc cag atc ggt gcg ctc agc cca gca 96
Ser Ala Val His Glu Asp Pro Thr Gln Ile Gly Ala Leu Ser Pro Ala
20 25 30
gtc gcc ggc acc ctt ggt tcc tac gcc atg atc ggc gtg atg atc ggt 144
Val Ala Gly Thr Leu Gly Ser Tyr Ala Met Ile Gly Val Met Ile Gly
35 40 45
gct cta tct gca ggt gcc gtt ggt gac cgc ctt ggt cgt cgc aaa gtt 192
Ala Leu Ser Ala Gly Ala Val Gly Asp Arg Leu Gly Arg Arg Lys Val
50 55 60
atg ctc acc gca atc gtc tgg ttc tct gtg ggc atg gcg ctg acc gcg 240
Met Leu Thr Ala Ile Val Trp Phe Ser Val Gly Met Ala Leu Thr Ala
65 70 75 80
ttc gcg tcc tcg att gcg ctg ttc ggt ttc ttg cgc ttc ctc acc gga 288
Phe Ala Ser Ser Ile Ala Leu Phe Gly Phe Leu Arg Phe Leu Thr Gly
85 90 95
ctt ggc gtg ggc atg atc gtt gca acc ggc ggc gca atc atc gcg gag 336
Leu Gly Val Gly Met Ile Val Ala Thr Gly Gly Ala Ile Ile Ala Glu
100 105 110
ttc gct cca gcg aat agg cgc aac ttg ttc aac gca atc gtg tac tcc 384
Phe Ala Pro Ala Asn Arg Arg Asn Leu Phe Asn Ala Ile Val Tyr Ser
115 120 125
ggt gtc cca gcc ggt ggc gtg ctg gct tct atc ctt gca ctg ctc ttt 432
Gly Val Pro Ala Gly Gly Val Leu Ala Ser Ile Leu Ala Leu Leu Phe
130 135 140
gaa gat gtc atc ggc tgg cgc gga ctc ttc ctc atc ggt gga tcc cca 480
Glu Asp Val Ile Gly Trp Arg Gly Leu Phe Leu Ile Gly Gly Ser Pro
145 150 155 160
cta ctg ttc ctc ctg cca ctt gca tac ttc ttc ctc cca gag tcc ccg 528
Leu Leu Phe Leu Leu Pro Leu Ala Tyr Phe Phe Leu Pro Glu Ser Pro
165 170 175
cgc tgg ctc acc tcc cgc ggc cgt gct gcg gac gcc aaa gcc ctc tgc 576
Arg Trp Leu Thr Ser Arg Gly Arg Ala Ala Asp Ala Lys Ala Leu Cys
180 185 190
gca cgc tat ggg ctg ccg acg gag gaa ttt gtc gtc gaa aag cag cag 624
Ala Arg Tyr Gly Leu Pro Thr Glu Glu Phe Val Val Glu Lys Gln Gln
195 200 205
gaa aca aag ggc acc gga ttc gct gga att ttc tcc tcc aag tac ctc 672
Glu Thr Lys Gly Thr Gly Phe Ala Gly Ile Phe Ser Ser Lys Tyr Leu
210 215 220
atg ggc acc att ctc atc ggc gca atg agc ttc atc ggg ctg ctt tcg 720
Met Gly Thr Ile Leu Ile Gly Ala Met Ser Phe Ile Gly Leu Leu Ser
225 230 235 240
acc tac ggc ctg aac acc tgg ttg cca aag atc atg gaa tcc aac ggc 768
Thr Tyr Gly Leu Asn Thr Trp Leu Pro Lys Ile Met Glu Ser Asn Gly
245 250 255
gca acc tca cat gat tcc ctg tac tcc ctg ctg ttc ctc aac ggc ggc 816
Ala Thr Ser His Asp Ser Leu Tyr Ser Leu Leu Phe Leu Asn Gly Gly
260 265 270
gca gtg ttc ggt ggc ctc atc gca tcc tgg ttc gct gac cgc atc ggc 864
Ala Val Phe Gly Gly Leu Ile Ala Ser Trp Phe Ala Asp Arg Ile Gly
275 280 285
gcg aag acc gtg atc acc tcc acc ttc gct ctc gcc gcg atc tgc ctc 912
Ala Lys Thr Val Ile Thr Ser Thr Phe Ala Leu Ala Ala Ile Cys Leu
290 295 300
gga gtc ctg cca aac atc tcc tcc tgg cca atg atg tac acc gca atc 960
Gly Val Leu Pro Asn Ile Ser Ser Trp Pro Met Met Tyr Thr Ala Ile
305 310 315 320
gca ttc gca ggc gtc ggc gtc ctg ggc acc cag gtt ctc acc tac ggc 1008
Ala Phe Ala Gly Val Gly Val Leu Gly Thr Gln Val Leu Thr Tyr Gly
325 330 335
ctg acc tcg aac ttc ttc gga acc gaa tgc cgc gca gcg gga gtt gca 1056
Leu Thr Ser Asn Phe Phe Gly Thr Glu Cys Arg Ala Ala Gly Val Ala
340 345 350
tgg tgt gca gga ttc ggc cga ctc ggc gga atc gtc gga cca gca atc 1104
Trp Cys Ala Gly Phe Gly Arg Leu Gly Gly Ile Val Gly Pro Ala Ile
355 360 365
ggt ggc ctg atc atc ggc gca gga ttc gga cca agc tcc gca ttc ctc 1152
Gly Gly Leu Ile Ile Gly Ala Gly Phe Gly Pro Ser Ser Ala Phe Leu
370 375 380
atc ttc gca gca gct gcc gca atc ggc gcg gtc tgc acc ttg ctg atc 1200
Ile Phe Ala Ala Ala Ala Ala Ile Gly Ala Val Cys Thr Leu Leu Ile
385 390 395 400
ccg cgc tcc cca gca gaa gta gag gtc aag gtc gcg cag gaa cca ctt 1248
Pro Arg Ser Pro Ala Glu Val Glu Val Lys Val Ala Gln Glu Pro Leu
405 410 415
gca cgt gtc taaccccaat taattcgaaa caa 1280
Ala Arg Val
<210> 408
<211> 419
<212> PRT
<213> Corynebacterium glutamicum
<400> 408
Thr Leu Val Pro Gln Val Tyr Glu Ile Val Ile Tyr Gly Ala Val Leu
1 5 10 15
Ser Ala Val His Glu Asp Pro Thr Gln Ile Gly Ala Leu Ser Pro Ala
20 25 30
Val Ala Gly Thr Leu Gly Ser Tyr Ala Met Ile Gly Val Met Ile Gly
35 40 45
Ala Leu Ser Ala Gly Ala Val Gly Asp Arg Leu Gly Arg Arg Lys Val
50 55 60
Met Leu Thr Ala Ile Val Trp Phe Ser Val Gly Met Ala Leu Thr Ala
65 70 75 80
Phe Ala Ser Ser Ile Ala Leu Phe Gly Phe Leu Arg Phe Leu Thr Gly
85 90 95
Leu Gly Val Gly Met Ile Val Ala Thr Gly Gly Ala Ile Ile Ala Glu
100 105 110
Phe Ala Pro Ala Asn Arg Arg Asn Leu Phe Asn Ala Ile Val Tyr Ser
115 120 125
Gly Val Pro Ala Gly Gly Val Leu Ala Ser Ile Leu Ala Leu Leu Phe
130 135 140
Glu Asp Val Ile Gly Trp Arg Gly Leu Phe Leu Ile Gly Gly Ser Pro
145 150 155 160
Leu Leu Phe Leu Leu Pro Leu Ala Tyr Phe Phe Leu Pro Glu Ser Pro
165 170 175
Arg Trp Leu Thr Ser Arg Gly Arg Ala Ala Asp Ala Lys Ala Leu Cys
180 185 190
Ala Arg Tyr Gly Leu Pro Thr Glu Glu Phe Val Val Glu Lys Gln Gln
195 200 205
Glu Thr Lys Gly Thr Gly Phe Ala Gly Ile Phe Ser Ser Lys Tyr Leu
210 215 220
Met Gly Thr Ile Leu Ile Gly Ala Met Ser Phe Ile Gly Leu Leu Ser
225 230 235 240
Thr Tyr Gly Leu Asn Thr Trp Leu Pro Lys Ile Met Glu Ser Asn Gly
245 250 255
Ala Thr Ser His Asp Ser Leu Tyr Ser Leu Leu Phe Leu Asn Gly Gly
260 265 270
Ala Val Phe Gly Gly Leu Ile Ala Ser Trp Phe Ala Asp Arg Ile Gly
275 280 285
Ala Lys Thr Val Ile Thr Ser Thr Phe Ala Leu Ala Ala Ile Cys Leu
290 295 300
Gly Val Leu Pro Asn Ile Ser Ser Trp Pro Met Met Tyr Thr Ala Ile
305 310 315 320
Ala Phe Ala Gly Val Gly Val Leu Gly Thr Gln Val Leu Thr Tyr Gly
325 330 335
Leu Thr Ser Asn Phe Phe Gly Thr Glu Cys Arg Ala Ala Gly Val Ala
340 345 350
Trp Cys Ala Gly Phe Gly Arg Leu Gly Gly Ile Val Gly Pro Ala Ile
355 360 365
Gly Gly Leu Ile Ile Gly Ala Gly Phe Gly Pro Ser Ser Ala Phe Leu
370 375 380
Ile Phe Ala Ala Ala Ala Ala Ile Gly Ala Val Cys Thr Leu Leu Ile
385 390 395 400
Pro Arg Ser Pro Ala Glu Val Glu Val Lys Val Ala Gln Glu Pro Leu
405 410 415
Ala Arg Val
<210> 409
<211> 1208
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(1185)
<223> FRXA00571
<400> 409
cag atc ggt gcg ctc agc cca gca gtc gcc ggc acc ctt ggt tcc tac 48
Gln Ile Gly Ala Leu Ser Pro Ala Val Ala Gly Thr Leu Gly Ser Tyr
1 5 10 15
gcc atg atc ggc gtg atg atc ggt gct cta tct gca ggt gcc gtt ggt 96
Ala Met Ile Gly Val Met Ile Gly Ala Leu Ser Ala Gly Ala Val Gly
20 25 30
gac cgc ctt ggt cgt cgc aaa gtt atg ctc acc gca atc gtc tgg ttc 144
Asp Arg Leu Gly Arg Arg Lys Val Met Leu Thr Ala Ile Val Trp Phe
35 40 45
tct gtg ggc atg gcg ctg acc gcg ttc gcg tcc tcg att gcg ctg ttc 192
Ser Val Gly Met Ala Leu Thr Ala Phe Ala Ser Ser Ile Ala Leu Phe
50 55 60
ggt ttc ttg cgc ttc ctc acc gga ctt ggc gtg ggc atg atc gtt gca 240
Gly Phe Leu Arg Phe Leu Thr Gly Leu Gly Val Gly Met Ile Val Ala
65 70 75 80
acc ggc ggc gca atc atc gcg gag ttc gct cca gcg aat agg cgc aac 288
Thr Gly Gly Ala Ile Ile Ala Glu Phe Ala Pro Ala Asn Arg Arg Asn
85 90 95
ttg ttc aac gca atc gtg tac tcc ggt gtc cca gcc ggt ggc gtg ctg 336
Leu Phe Asn Ala Ile Val Tyr Ser Gly Val Pro Ala Gly Gly Val Leu
100 105 110
gct tct atc ctt gca ctg ctc ttt gaa gat gtc atc ggc tgg cgc gga 384
Ala Ser Ile Leu Ala Leu Leu Phe Glu Asp Val Ile Gly Trp Arg Gly
115 120 125
ctc ttc ctc atc ggt gga tcc cca cta ctg ttc ctc ctg cca ctt gca 432
Leu Phe Leu Ile Gly Gly Ser Pro Leu Leu Phe Leu Leu Pro Leu Ala
130 135 140
tac ttc ttc ctc cca gag tcc ccg cgc tgg ctc acc tcc cgc ggc cgt 480
Tyr Phe Phe Leu Pro Glu Ser Pro Arg Trp Leu Thr Ser Arg Gly Arg
145 150 155 160
gct gcg gac gcc aaa gcc ctc tgc gca cgc tat ggg ctg ccg acg gag 528
Ala Ala Asp Ala Lys Ala Leu Cys Ala Arg Tyr Gly Leu Pro Thr Glu
165 170 175
gaa ttt gtc gtc gaa aag cag cag gaa aca aag ggc acc gga ttc gct 576
Glu Phe Val Val Glu Lys Gln Gln Glu Thr Lys Gly Thr Gly Phe Ala
180 185 190
gga att ttc tcc tcc aag tac ctc atg ggc acc att ctc atc ggc gca 624
Gly Ile Phe Ser Ser Lys Tyr Leu Met Gly Thr Ile Leu Ile Gly Ala
195 200 205
atg agc ttc atc ggg ctg ctt tcg acc tac ggc ctg aac acc tgg ttg 672
Met Ser Phe Ile Gly Leu Leu Ser Thr Tyr Gly Leu Asn Thr Trp Leu
210 215 220
cca aag atc atg gaa tcc aac ggc gca acc tca cat gat tcc ctg tac 720
Pro Lys Ile Met Glu Ser Asn Gly Ala Thr Ser His Asp Ser Leu Tyr
225 230 235 240
tcc ctg ctg ttc ctc aac ggc ggc gca gtg ttc ggt ggc ctc atc gca 768
Ser Leu Leu Phe Leu Asn Gly Gly Ala Val Phe Gly Gly Leu Ile Ala
245 250 255
tcc tgg ttc gct gac cgc atc ggc gcg aag acc gtg atc acc tcc acc 816
Ser Trp Phe Ala Asp Arg Ile Gly Ala Lys Thr Val Ile Thr Ser Thr
260 265 270
ttc gct ctc gcc gcg atc tgc ctc gga gtc ctg cca aac atc tcc tcc 864
Phe Ala Leu Ala Ala Ile Cys Leu Gly Val Leu Pro Asn Ile Ser Ser
275 280 285
tgg cca atg atg tac acc gca atc gca ttc gca ggc gtc ggc gtc ctg 912
Trp Pro Met Met Tyr Thr Ala Ile Ala Phe Ala Gly Val Gly Val Leu
290 295 300
ggc acc cag gtt ctc acc tac ggc ctg acc tcg aac ttc ttc gga acc 960
Gly Thr Gln Val Leu Thr Tyr Gly Leu Thr Ser Asn Phe Phe Gly Thr
305 310 315 320
gaa tgc cgc gca gcg gga gtt gca tgg tgt gca gga ttc ggc cga ctc 1008
Glu Cys Arg Ala Ala Gly Val Ala Trp Cys Ala Gly Phe Gly Arg Leu
325 330 335
ggc gga atc gtc gga cca gca atc ggt ggc ctg atc atc ggc gca gga 1056
Gly Gly Ile Val Gly Pro Ala Ile Gly Gly Leu Ile Ile Gly Ala Gly
340 345 350
ttc gga cca agc tcc gca ttc ctc atc ttc gca gca gct gcc gca atc 1104
Phe Gly Pro Ser Ser Ala Phe Leu Ile Phe Ala Ala Ala Ala Ala Ile
355 360 365
ggc gcg gtc tgc acc ttg ctg atc ccg cgc tcc cca gca gaa gta gag 1152
Gly Ala Val Cys Thr Leu Leu Ile Pro Arg Ser Pro Ala Glu Val Glu
370 375 380
gtc aag gtc gcg cag gaa cca ctt gca cgt gtc taaccccaat taattcgaaa 1205
Val Lys Val Ala Gln Glu Pro Leu Ala Arg Val
385 390 395
caa 1208
<210> 410
<211> 395
<212> PRT
<213> Corynebacterium glutamicum
<400> 410
Gln Ile Gly Ala Leu Ser Pro Ala Val Ala Gly Thr Leu Gly Ser Tyr
1 5 10 15
Ala Met Ile Gly Val Met Ile Gly Ala Leu Ser Ala Gly Ala Val Gly
20 25 30
Asp Arg Leu Gly Arg Arg Lys Val Met Leu Thr Ala Ile Val Trp Phe
35 40 45
Ser Val Gly Met Ala Leu Thr Ala Phe Ala Ser Ser Ile Ala Leu Phe
50 55 60
Gly Phe Leu Arg Phe Leu Thr Gly Leu Gly Val Gly Met Ile Val Ala
65 70 75 80
Thr Gly Gly Ala Ile Ile Ala Glu Phe Ala Pro Ala Asn Arg Arg Asn
85 90 95
Leu Phe Asn Ala Ile Val Tyr Ser Gly Val Pro Ala Gly Gly Val Leu
100 105 110
Ala Ser Ile Leu Ala Leu Leu Phe Glu Asp Val Ile Gly Trp Arg Gly
115 120 125
Leu Phe Leu Ile Gly Gly Ser Pro Leu Leu Phe Leu Leu Pro Leu Ala
130 135 140
Tyr Phe Phe Leu Pro Glu Ser Pro Arg Trp Leu Thr Ser Arg Gly Arg
145 150 155 160
Ala Ala Asp Ala Lys Ala Leu Cys Ala Arg Tyr Gly Leu Pro Thr Glu
165 170 175
Glu Phe Val Val Glu Lys Gln Gln Glu Thr Lys Gly Thr Gly Phe Ala
180 185 190
Gly Ile Phe Ser Ser Lys Tyr Leu Met Gly Thr Ile Leu Ile Gly Ala
195 200 205
Met Ser Phe Ile Gly Leu Leu Ser Thr Tyr Gly Leu Asn Thr Trp Leu
210 215 220
Pro Lys Ile Met Glu Ser Asn Gly Ala Thr Ser His Asp Ser Leu Tyr
225 230 235 240
Ser Leu Leu Phe Leu Asn Gly Gly Ala Val Phe Gly Gly Leu Ile Ala
245 250 255
Ser Trp Phe Ala Asp Arg Ile Gly Ala Lys Thr Val Ile Thr Ser Thr
260 265 270
Phe Ala Leu Ala Ala Ile Cys Leu Gly Val Leu Pro Asn Ile Ser Ser
275 280 285
Trp Pro Met Met Tyr Thr Ala Ile Ala Phe Ala Gly Val Gly Val Leu
290 295 300
Gly Thr Gln Val Leu Thr Tyr Gly Leu Thr Ser Asn Phe Phe Gly Thr
305 310 315 320
Glu Cys Arg Ala Ala Gly Val Ala Trp Cys Ala Gly Phe Gly Arg Leu
325 330 335
Gly Gly Ile Val Gly Pro Ala Ile Gly Gly Leu Ile Ile Gly Ala Gly
340 345 350
Phe Gly Pro Ser Ser Ala Phe Leu Ile Phe Ala Ala Ala Ala Ala Ile
355 360 365
Gly Ala Val Cys Thr Leu Leu Ile Pro Arg Ser Pro Ala Glu Val Glu
370 375 380
Val Lys Val Ala Gln Glu Pro Leu Ala Arg Val
385 390 395
<210> 411
<211> 689
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(666)
<223> RXA00962
<400> 411
gat aag gcc atc aag gcg gat cac gac att aga gaa ggc cac gat gag 48
Asp Lys Ala Ile Lys Ala Asp His Asp Ile Arg Glu Gly His Asp Glu
1 5 10 15
cca gca ggt ttc aag gat ctg ctt gtc gat cgc tac cgc tgg atc tcc 96
Pro Ala Gly Phe Lys Asp Leu Leu Val Asp Arg Tyr Arg Trp Ile Ser
20 25 30
att tgg ttc gcg ctc gcc aca ttt gtc acc ctg ctc gcg tgg tac gga 144
Ile Trp Phe Ala Leu Ala Thr Phe Val Thr Leu Leu Ala Trp Tyr Gly
35 40 45
ctg ggc aca tgg ttg cct cgc ctc atg gaa act gca ggt tat gag ttc 192
Leu Gly Thr Trp Leu Pro Arg Leu Met Glu Thr Ala Gly Tyr Glu Phe
50 55 60
ggc cat gca ttg atg ttc acc ctg gct ctg aac ctc ggt gca gtg atc 240
Gly His Ala Leu Met Phe Thr Leu Ala Leu Asn Leu Gly Ala Val Ile
65 70 75 80
gga tcc gtg gtt act gcg tgg gcc ggc gat cgc ttc ggg cca atc cgt 288
Gly Ser Val Val Thr Ala Trp Ala Gly Asp Arg Phe Gly Pro Ile Arg
85 90 95
tcc ggt gtc atc gct gca ggt atc gcc ggt att gca ctg ctc ctg ctg 336
Ser Gly Val Ile Ala Ala Gly Ile Ala Gly Ile Ala Leu Leu Leu Leu
100 105 110
ctc act tac ccg cct gtc acc gcg gtt tat gtc att ctc att ttg gct 384
Leu Thr Tyr Pro Pro Val Thr Ala Val Tyr Val Ile Leu Ile Leu Ala
115 120 125
ggc gtg ggc acc cac ggc act cag atc ctc atc att gca gct gtc gcc 432
Gly Val Gly Thr His Gly Thr Gln Ile Leu Ile Ile Ala Ala Val Ala
130 135 140
aac ttc tac cca agc aac ctg cgt ggc aca gca ctg ggc tgg gcg cta 480
Asn Phe Tyr Pro Ser Asn Leu Arg Gly Thr Ala Leu Gly Trp Ala Leu
145 150 155 160
ggt gta ggt cgt att ggt gct gtt gtg gcc ccg cag ctc gct ggc ctg 528
Gly Val Gly Arg Ile Gly Ala Val Val Ala Pro Gln Leu Ala Gly Leu
165 170 175
ctg ctg gca tgg aac ttg ggc gtg aac tcc aac ttc atc atg ttc ggc 576
Leu Leu Ala Trp Asn Leu Gly Val Asn Ser Asn Phe Ile Met Phe Gly
180 185 190
acc gct gcg ctg ctc tct gcg ctg gct ctc agc gtg ttg ctg cgc ctg 624
Thr Ala Ala Leu Leu Ser Ala Leu Ala Leu Ser Val Leu Leu Arg Leu
195 200 205
cag aaa acc tac agc gtc acc cac aaa gtc gaa atc caa ggc 666
Gln Lys Thr Tyr Ser Val Thr His Lys Val Glu Ile Gln Gly
210 215 220
taaccccctt tttcaactca cag 689
<210> 412
<211> 222
<212> PRT
<213> Corynebacterium glutamicum
<400> 412
Asp Lys Ala Ile Lys Ala Asp His Asp Ile Arg Glu Gly His Asp Glu
1 5 10 15
Pro Ala Gly Phe Lys Asp Leu Leu Val Asp Arg Tyr Arg Trp Ile Ser
20 25 30
Ile Trp Phe Ala Leu Ala Thr Phe Val Thr Leu Leu Ala Trp Tyr Gly
35 40 45
Leu Gly Thr Trp Leu Pro Arg Leu Met Glu Thr Ala Gly Tyr Glu Phe
50 55 60
Gly His Ala Leu Met Phe Thr Leu Ala Leu Asn Leu Gly Ala Val Ile
65 70 75 80
Gly Ser Val Val Thr Ala Trp Ala Gly Asp Arg Phe Gly Pro Ile Arg
85 90 95
Ser Gly Val Ile Ala Ala Gly Ile Ala Gly Ile Ala Leu Leu Leu Leu
100 105 110
Leu Thr Tyr Pro Pro Val Thr Ala Val Tyr Val Ile Leu Ile Leu Ala
115 120 125
Gly Val Gly Thr His Gly Thr Gln Ile Leu Ile Ile Ala Ala Val Ala
130 135 140
Asn Phe Tyr Pro Ser Asn Leu Arg Gly Thr Ala Leu Gly Trp Ala Leu
145 150 155 160
Gly Val Gly Arg Ile Gly Ala Val Val Ala Pro Gln Leu Ala Gly Leu
165 170 175
Leu Leu Ala Trp Asn Leu Gly Val Asn Ser Asn Phe Ile Met Phe Gly
180 185 190
Thr Ala Ala Leu Leu Ser Ala Leu Ala Leu Ser Val Leu Leu Arg Leu
195 200 205
Gln Lys Thr Tyr Ser Val Thr His Lys Val Glu Ile Gln Gly
210 215 220
<210> 413
<211> 484
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(484)
<223> RXA02811
<400> 413
cataatcact ctttccagat agcggaatcc ctttgattgt aacttggctc acctcgatta 60
tgtgtttatg acatcacacg caccagaatc gggaggactt gtg aca gag tca act 115
Val Thr Glu Ser Thr
1 5
ctc gga gca tcg aat agc tcc caa aca att gaa aat aaa ggc ctc acc 163
Leu Gly Ala Ser Asn Ser Ser Gln Thr Ile Glu Asn Lys Gly Leu Thr
10 15 20
atc ttg ggc atc agc ggc cga cgc ttg gct gcg gtg ctc att ggc tgg 211
Ile Leu Gly Ile Ser Gly Arg Arg Leu Ala Ala Val Leu Ile Gly Trp
25 30 35
ttt ttt gtc att ttc gac ggc tac gac ctc att gtg tac ggc acc gtc 259
Phe Phe Val Ile Phe Asp Gly Tyr Asp Leu Ile Val Tyr Gly Thr Val
40 45 50
caa tcg gcc ctg gct aag gag tgg aac tta agc tct gca acg ctg ggc 307
Gln Ser Ala Leu Ala Lys Glu Trp Asn Leu Ser Ser Ala Thr Leu Gly
55 60 65
acc atc ggc tcc acc gcg ttc ttt ggc atg gcg atc ggc gct gtg ttc 355
Thr Ile Gly Ser Thr Ala Phe Phe Gly Met Ala Ile Gly Ala Val Phe
70 75 80 85
att ggt cga ctg tca gac cgc gtg ggc cga aaa gca gcg gtg att gga 403
Ile Gly Arg Leu Ser Asp Arg Val Gly Arg Lys Ala Ala Val Ile Gly
90 95 100
tcc gtg ctg att ctc tct gtc ttc acc atg ctg tgt gca ttt gct cca 451
Ser Val Leu Ile Leu Ser Val Phe Thr Met Leu Cys Ala Phe Ala Pro
105 110 115
aac cca tgg gtg ttc ggc gct ttc cgt ttc atc 484
Asn Pro Trp Val Phe Gly Ala Phe Arg Phe Ile
120 125
<210> 414
<211> 128
<212> PRT
<213> Corynebacterium glutamicum
<400> 414
Val Thr Glu Ser Thr Leu Gly Ala Ser Asn Ser Ser Gln Thr Ile Glu
1 5 10 15
Asn Lys Gly Leu Thr Ile Leu Gly Ile Ser Gly Arg Arg Leu Ala Ala
20 25 30
Val Leu Ile Gly Trp Phe Phe Val Ile Phe Asp Gly Tyr Asp Leu Ile
35 40 45
Val Tyr Gly Thr Val Gln Ser Ala Leu Ala Lys Glu Trp Asn Leu Ser
50 55 60
Ser Ala Thr Leu Gly Thr Ile Gly Ser Thr Ala Phe Phe Gly Met Ala
65 70 75 80
Ile Gly Ala Val Phe Ile Gly Arg Leu Ser Asp Arg Val Gly Arg Lys
85 90 95
Ala Ala Val Ile Gly Ser Val Leu Ile Leu Ser Val Phe Thr Met Leu
100 105 110
Cys Ala Phe Ala Pro Asn Pro Trp Val Phe Gly Ala Phe Arg Phe Ile
115 120 125
<210> 415
<211> 1197
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(1197)
<223> RXA02115
<400> 415
acc cgc gca acc aaa agt gtc gga aca gtt ctc gca ctc ctg tgg ttc 48
Thr Arg Ala Thr Lys Ser Val Gly Thr Val Leu Ala Leu Leu Trp Phe
1 5 10 15
gca att gtc ctc gac ggc ttt gac cta gtc gtc ctg ggt gca aca atc 96
Ala Ile Val Leu Asp Gly Phe Asp Leu Val Val Leu Gly Ala Thr Ile
20 25 30
ccg tcc atg ctg gag gat ccc gcg tgg gat ctc act gct gga cag gcc 144
Pro Ser Met Leu Glu Asp Pro Ala Trp Asp Leu Thr Ala Gly Gln Ala
35 40 45
aca cag att tcc acc atc ggc ctc gtc ggc atg acc att ggc gca ctg 192
Thr Gln Ile Ser Thr Ile Gly Leu Val Gly Met Thr Ile Gly Ala Leu
50 55 60
acc atc ggt ttc tta acg gac cgt ctg ggt cga cgc cgt gtc atg ctg 240
Thr Ile Gly Phe Leu Thr Asp Arg Leu Gly Arg Arg Arg Val Met Leu
65 70 75 80
ttc tct gtg gca gta ttt tct gta ttc act ctc ctg ctg gca ttc acc 288
Phe Ser Val Ala Val Phe Ser Val Phe Thr Leu Leu Leu Ala Phe Thr
85 90 95
acc aac gtc cag ctc ttc agc ctg tgg cgt ttc ctc gca ggt gtt ggc 336
Thr Asn Val Gln Leu Phe Ser Leu Trp Arg Phe Leu Ala Gly Val Gly
100 105 110
ctt ggt gga gca ctc ccc acc gca att gcc atg gtg acc gag ttc cgc 384
Leu Gly Gly Ala Leu Pro Thr Ala Ile Ala Met Val Thr Glu Phe Arg
115 120 125
ccc ggc acc aaa gcg ggc tct gca tcc acc acc ttg atg acc ggc tac 432
Pro Gly Thr Lys Ala Gly Ser Ala Ser Thr Thr Leu Met Thr Gly Tyr
130 135 140
cac gtc ggc gca gta gca acc gcc ttc ctt ggc ctc ttc ctt atc gac 480
His Val Gly Ala Val Ala Thr Ala Phe Leu Gly Leu Phe Leu Ile Asp
145 150 155 160
ggc ttt ggt tgg cac tcc atg ttc atc gca ggt gcc gta cca gga ctg 528
Gly Phe Gly Trp His Ser Met Phe Ile Ala Gly Ala Val Pro Gly Leu
165 170 175
atc ctg cta cca ctg ctg tac ttc ttc ctt cca gaa tcc ccg cag tac 576
Ile Leu Leu Pro Leu Leu Tyr Phe Phe Leu Pro Glu Ser Pro Gln Tyr
180 185 190
ctc aaa atc tcc ggc aag ttg gat gag gcg cag gca gtt gca gca tct 624
Leu Lys Ile Ser Gly Lys Leu Asp Glu Ala Gln Ala Val Ala Ala Ser
195 200 205
tat gga ctt tcc ctg gat gat gat ctt gat cgc gaa cac gaa gaa gaa 672
Tyr Gly Leu Ser Leu Asp Asp Asp Leu Asp Arg Glu His Glu Glu Glu
210 215 220
ctc ggc gag tcc tcc tca ctt tcc tcc ctg ttc aag ccc tcg ttc cgc 720
Leu Gly Glu Ser Ser Ser Leu Ser Ser Leu Phe Lys Pro Ser Phe Arg
225 230 235 240
cgc aac acc ctg gcg att tgg ggc acc tca ttc atg gga ctc ctc ctg 768
Arg Asn Thr Leu Ala Ile Trp Gly Thr Ser Phe Met Gly Leu Leu Leu
245 250 255
gtc tac ggc ctg aac aca tgg ctg cca caa atc atg cgc caa gca gac 816
Val Tyr Gly Leu Asn Thr Trp Leu Pro Gln Ile Met Arg Gln Ala Asp
260 265 270
tac gac atg ggt aac tcg ctt gga ttc ctc atg gtg ctc aac atc ggc 864
Tyr Asp Met Gly Asn Ser Leu Gly Phe Leu Met Val Leu Asn Ile Gly
275 280 285
gca gtg atc ggc ctt tat att gca ggg cga att gcc gat aag aac tcc 912
Ala Val Ile Gly Leu Tyr Ile Ala Gly Arg Ile Ala Asp Lys Asn Ser
290 295 300
cct cgc aaa aca gca ctc gta tgg ttc gtg ttc tct gca ttt tcc ctc 960
Pro Arg Lys Thr Ala Leu Val Trp Phe Val Phe Ser Ala Phe Ser Leu
305 310 315 320
gcg ttg ctt gct gtc cgg atg cca ctg atc ggt ctg tat ggc atc gtg 1008
Ala Leu Leu Ala Val Arg Met Pro Leu Ile Gly Leu Tyr Gly Ile Val
325 330 335
ctg ctc acc ggc atc ttt gtg ttc agc tcc cag gta ctc atc tac gcc 1056
Leu Leu Thr Gly Ile Phe Val Phe Ser Ser Gln Val Leu Ile Tyr Ala
340 345 350
ttc gtt ggt gag aat cac cct gcc aag atg cgc gca acc gcc atg gga 1104
Phe Val Gly Glu Asn His Pro Ala Lys Met Arg Ala Thr Ala Met Gly
355 360 365
ttc tcc gca gga att ggt cgc ctc ggc gcc atc tct ggc ccg ttg ctt 1152
Phe Ser Ala Gly Ile Gly Arg Leu Gly Ala Ile Ser Gly Pro Leu Leu
370 375 380
ggt ggt ctg ctt gtc agt gcc aac ctt gct tac cca tgg ggc ttc 1197
Gly Gly Leu Leu Val Ser Ala Asn Leu Ala Tyr Pro Trp Gly Phe
385 390 395
<210> 416
<211> 399
<212> PRT
<213> Corynebacterium glutamicum
<400> 416
Thr Arg Ala Thr Lys Ser Val Gly Thr Val Leu Ala Leu Leu Trp Phe
1 5 10 15
Ala Ile Val Leu Asp Gly Phe Asp Leu Val Val Leu Gly Ala Thr Ile
20 25 30
Pro Ser Met Leu Glu Asp Pro Ala Trp Asp Leu Thr Ala Gly Gln Ala
35 40 45
Thr Gln Ile Ser Thr Ile Gly Leu Val Gly Met Thr Ile Gly Ala Leu
50 55 60
Thr Ile Gly Phe Leu Thr Asp Arg Leu Gly Arg Arg Arg Val Met Leu
65 70 75 80
Phe Ser Val Ala Val Phe Ser Val Phe Thr Leu Leu Leu Ala Phe Thr
85 90 95
Thr Asn Val Gln Leu Phe Ser Leu Trp Arg Phe Leu Ala Gly Val Gly
100 105 110
Leu Gly Gly Ala Leu Pro Thr Ala Ile Ala Met Val Thr Glu Phe Arg
115 120 125
Pro Gly Thr Lys Ala Gly Ser Ala Ser Thr Thr Leu Met Thr Gly Tyr
130 135 140
His Val Gly Ala Val Ala Thr Ala Phe Leu Gly Leu Phe Leu Ile Asp
145 150 155 160
Gly Phe Gly Trp His Ser Met Phe Ile Ala Gly Ala Val Pro Gly Leu
165 170 175
Ile Leu Leu Pro Leu Leu Tyr Phe Phe Leu Pro Glu Ser Pro Gln Tyr
180 185 190
Leu Lys Ile Ser Gly Lys Leu Asp Glu Ala Gln Ala Val Ala Ala Ser
195 200 205
Tyr Gly Leu Ser Leu Asp Asp Asp Leu Asp Arg Glu His Glu Glu Glu
210 215 220
Leu Gly Glu Ser Ser Ser Leu Ser Ser Leu Phe Lys Pro Ser Phe Arg
225 230 235 240
Arg Asn Thr Leu Ala Ile Trp Gly Thr Ser Phe Met Gly Leu Leu Leu
245 250 255
Val Tyr Gly Leu Asn Thr Trp Leu Pro Gln Ile Met Arg Gln Ala Asp
260 265 270
Tyr Asp Met Gly Asn Ser Leu Gly Phe Leu Met Val Leu Asn Ile Gly
275 280 285
Ala Val Ile Gly Leu Tyr Ile Ala Gly Arg Ile Ala Asp Lys Asn Ser
290 295 300
Pro Arg Lys Thr Ala Leu Val Trp Phe Val Phe Ser Ala Phe Ser Leu
305 310 315 320
Ala Leu Leu Ala Val Arg Met Pro Leu Ile Gly Leu Tyr Gly Ile Val
325 330 335
Leu Leu Thr Gly Ile Phe Val Phe Ser Ser Gln Val Leu Ile Tyr Ala
340 345 350
Phe Val Gly Glu Asn His Pro Ala Lys Met Arg Ala Thr Ala Met Gly
355 360 365
Phe Ser Ala Gly Ile Gly Arg Leu Gly Ala Ile Ser Gly Pro Leu Leu
370 375 380
Gly Gly Leu Leu Val Ser Ala Asn Leu Ala Tyr Pro Trp Gly Phe
385 390 395
<210> 417
<211> 1288
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1288)
<223> RXN00590
<400> 417
tctaaactca ctctcaactc accaagattg ttcaacaatc tgcgattggt gtgcaatcta 60
ccccaatcat tttgaaagcc cccacgaaag gagcgcgaca atg gcc gac aac aaa 115
Met Ala Asp Asn Lys
1 5
aat gcc gat gac agc cag cta gtc tca gcc agc act gga acc cct ggg 163
Asn Ala Asp Asp Ser Gln Leu Val Ser Ala Ser Thr Gly Thr Pro Gly
10 15 20
cct ggc gac att gca aaa gcc aat gcg cca tcc ctc aag caa gct gca 211
Pro Gly Asp Ile Ala Lys Ala Asn Ala Pro Ser Leu Lys Gln Ala Ala
25 30 35
gta acc gcc tct ggc cga agc gct ctg atg ggt gcc atc ttc ctc atg 259
Val Thr Ala Ser Gly Arg Ser Ala Leu Met Gly Ala Ile Phe Leu Met
40 45 50
gca act tct gcc atc ggc cca ggg ttc ctc acc caa acc gct gtc ttc 307
Ala Thr Ser Ala Ile Gly Pro Gly Phe Leu Thr Gln Thr Ala Val Phe
55 60 65
acc aac cag ctc ggc gca gct ttc gca ttt gcg atc ctg gtg tcg atc 355
Thr Asn Gln Leu Gly Ala Ala Phe Ala Phe Ala Ile Leu Val Ser Ile
70 75 80 85
ctc att gac atc gcg gtg cag ctg aat gtg tgg cgc atc atc ggc gtc 403
Leu Ile Asp Ile Ala Val Gln Leu Asn Val Trp Arg Ile Ile Gly Val
90 95 100
tct gaa atg cgc gcc caa gaa ctc ggc aac acg gtt atc cca ggt ttt 451
Ser Glu Met Arg Ala Gln Glu Leu Gly Asn Thr Val Ile Pro Gly Phe
105 110 115
ggt tgg gtg ctg gcc gta ctg gtc tgt att ggc ggc gta gta ttc aac 499
Gly Trp Val Leu Ala Val Leu Val Cys Ile Gly Gly Val Val Phe Asn
120 125 130
atc ggc aac atc gcc ggt ggt ggc ctt ggg ctt aac gcg ctg ctt ggc 547
Ile Gly Asn Ile Ala Gly Gly Gly Leu Gly Leu Asn Ala Leu Leu Gly
135 140 145
tgg gac gtc aaa gtt ggt ggc gtg atc acc gcg gcc atc gcg att gcg 595
Trp Asp Val Lys Val Gly Gly Val Ile Thr Ala Ala Ile Ala Ile Ala
150 155 160 165
atc ttc ttg ttc aag cga ctt ggt gct gct ctg gac aaa ttc ctc gtg 643
Ile Phe Leu Phe Lys Arg Leu Gly Ala Ala Leu Asp Lys Phe Leu Val
170 175 180
gtc ctc ggc gtc gtg atg atc ctg ctc acc gtc tac gtg gct ttc gtc 691
Val Leu Gly Val Val Met Ile Leu Leu Thr Val Tyr Val Ala Phe Val
185 190 195
tcc caa cct cca gtt ggc tcg gcg ctg aag aat gca gta ctt cct gac 739
Ser Gln Pro Pro Val Gly Ser Ala Leu Lys Asn Ala Val Leu Pro Asp
200 205 210
acc atc gac tgg ctt gtc atc acc aca ctt gtg ggt gga acc gtc ggt 787
Thr Ile Asp Trp Leu Val Ile Thr Thr Leu Val Gly Gly Thr Val Gly
215 220 225
gga tac atc act tac gct ggc gca cac cgc atg ctg gac tcc gga cga 835
Gly Tyr Ile Thr Tyr Ala Gly Ala His Arg Met Leu Asp Ser Gly Arg
230 235 240 245
acc ggc ccc aac aac gtc aaa gct gtt tcc aat tcc tct atc acc ggc 883
Thr Gly Pro Asn Asn Val Lys Ala Val Ser Asn Ser Ser Ile Thr Gly
250 255 260
atc ctg atc act ggc ctc atg cgc gtg gtg ctc ttc ctc gcg gtt ctc 931
Ile Leu Ile Thr Gly Leu Met Arg Val Val Leu Phe Leu Ala Val Leu
265 270 275
ggt gtt gtc gca ggt ggc gtc acc cta tcc acc acg ggc aac cca gcc 979
Gly Val Val Ala Gly Gly Val Thr Leu Ser Thr Thr Gly Asn Pro Ala
280 285 290
gcg gaa gca ttc cag cac gct gca ggc gat atc gga cta cgc atc ttc 1027
Ala Glu Ala Phe Gln His Ala Ala Gly Asp Ile Gly Leu Arg Ile Phe
295 300 305
ggc gcc gtg ctg tgg gca gcg tcc att tcc tca gtc atc ggc gcc agc 1075
Gly Ala Val Leu Trp Ala Ala Ser Ile Ser Ser Val Ile Gly Ala Ser
310 315 320 325
tac acc tct gca acc ttc ctg gtg gaa aac aag cca gag aag aag cgt 1123
Tyr Thr Ser Ala Thr Phe Leu Val Glu Asn Lys Pro Glu Lys Lys Arg
330 335 340
ctg caa aac tgg gtg acc atc atc ttc atc ctg att tct tgc tcc gtg 1171
Leu Gln Asn Trp Val Thr Ile Ile Phe Ile Leu Ile Ser Cys Ser Val
345 350 355
ttc atc atg ctc ggc acg gca cca gca atc ctc ttg gtc ttc gcc gga 1219
Phe Ile Met Leu Gly Thr Ala Pro Ala Ile Leu Leu Val Phe Ala Gly
360 365 370
gca ttc aac ggt ttg gtc ctc ccc gta ggc ttt acc ctg atg atc tac 1267
Ala Phe Asn Gly Leu Val Leu Pro Val Gly Phe Thr Leu Met Ile Tyr
375 380 385
gta gcg atc ttc cgc caa aaa 1288
Val Ala Ile Phe Arg Gln Lys
390 395
<210> 418
<211> 396
<212> PRT
<213> Corynebacterium glutamicum
<400> 418
Met Ala Asp Asn Lys Asn Ala Asp Asp Ser Gln Leu Val Ser Ala Ser
1 5 10 15
Thr Gly Thr Pro Gly Pro Gly Asp Ile Ala Lys Ala Asn Ala Pro Ser
20 25 30
Leu Lys Gln Ala Ala Val Thr Ala Ser Gly Arg Ser Ala Leu Met Gly
35 40 45
Ala Ile Phe Leu Met Ala Thr Ser Ala Ile Gly Pro Gly Phe Leu Thr
50 55 60
Gln Thr Ala Val Phe Thr Asn Gln Leu Gly Ala Ala Phe Ala Phe Ala
65 70 75 80
Ile Leu Val Ser Ile Leu Ile Asp Ile Ala Val Gln Leu Asn Val Trp
85 90 95
Arg Ile Ile Gly Val Ser Glu Met Arg Ala Gln Glu Leu Gly Asn Thr
100 105 110
Val Ile Pro Gly Phe Gly Trp Val Leu Ala Val Leu Val Cys Ile Gly
115 120 125
Gly Val Val Phe Asn Ile Gly Asn Ile Ala Gly Gly Gly Leu Gly Leu
130 135 140
Asn Ala Leu Leu Gly Trp Asp Val Lys Val Gly Gly Val Ile Thr Ala
145 150 155 160
Ala Ile Ala Ile Ala Ile Phe Leu Phe Lys Arg Leu Gly Ala Ala Leu
165 170 175
Asp Lys Phe Leu Val Val Leu Gly Val Val Met Ile Leu Leu Thr Val
180 185 190
Tyr Val Ala Phe Val Ser Gln Pro Pro Val Gly Ser Ala Leu Lys Asn
195 200 205
Ala Val Leu Pro Asp Thr Ile Asp Trp Leu Val Ile Thr Thr Leu Val
210 215 220
Gly Gly Thr Val Gly Gly Tyr Ile Thr Tyr Ala Gly Ala His Arg Met
225 230 235 240
Leu Asp Ser Gly Arg Thr Gly Pro Asn Asn Val Lys Ala Val Ser Asn
245 250 255
Ser Ser Ile Thr Gly Ile Leu Ile Thr Gly Leu Met Arg Val Val Leu
260 265 270
Phe Leu Ala Val Leu Gly Val Val Ala Gly Gly Val Thr Leu Ser Thr
275 280 285
Thr Gly Asn Pro Ala Ala Glu Ala Phe Gln His Ala Ala Gly Asp Ile
290 295 300
Gly Leu Arg Ile Phe Gly Ala Val Leu Trp Ala Ala Ser Ile Ser Ser
305 310 315 320
Val Ile Gly Ala Ser Tyr Thr Ser Ala Thr Phe Leu Val Glu Asn Lys
325 330 335
Pro Glu Lys Lys Arg Leu Gln Asn Trp Val Thr Ile Ile Phe Ile Leu
340 345 350
Ile Ser Cys Ser Val Phe Ile Met Leu Gly Thr Ala Pro Ala Ile Leu
355 360 365
Leu Val Phe Ala Gly Ala Phe Asn Gly Leu Val Leu Pro Val Gly Phe
370 375 380
Thr Leu Met Ile Tyr Val Ala Ile Phe Arg Gln Lys
385 390 395
<210> 419
<211> 487
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(487)
<223> FRXA00590
<400> 419
tacgctggcg cacaccgcat gctggactcc ggacgaaccg gccccaacac gtcaaagctg 60
tttccaattc tctatcaccg gcatcctgat cactggcctc atg cgc gtg gtg ctc 115
Met Arg Val Val Leu
1 5
ttc ctc gcg gtt ctc ggt gtt gtc gca ggt ggc gtc acc cta tcc acc 163
Phe Leu Ala Val Leu Gly Val Val Ala Gly Gly Val Thr Leu Ser Thr
10 15 20
acg ggc aac cca gcc gcg gaa gca ttc cag cac gct gca ggc gat atc 211
Thr Gly Asn Pro Ala Ala Glu Ala Phe Gln His Ala Ala Gly Asp Ile
25 30 35
gga cta cgc atc ttc ggc gcc gtg ctg tgg gca gcg tcc att tcc tca 259
Gly Leu Arg Ile Phe Gly Ala Val Leu Trp Ala Ala Ser Ile Ser Ser
40 45 50
gtc atc ggc gcc agc tac acc tct gca acc ttc ctg gtg gaa aac aag 307
Val Ile Gly Ala Ser Tyr Thr Ser Ala Thr Phe Leu Val Glu Asn Lys
55 60 65
cca gag aag aag cgt ctg caa aac tgg gtg acc atc atc ttc atc ctg 355
Pro Glu Lys Lys Arg Leu Gln Asn Trp Val Thr Ile Ile Phe Ile Leu
70 75 80 85
att tct tgc tcc gtg ttc atc atg ctc ggc acg gca cca gca atc ctc 403
Ile Ser Cys Ser Val Phe Ile Met Leu Gly Thr Ala Pro Ala Ile Leu
90 95 100
ttg gtc ttc gcc gga gca ttc aac ggt ttg gtc ctc ccc gta ggc ttt 451
Leu Val Phe Ala Gly Ala Phe Asn Gly Leu Val Leu Pro Val Gly Phe
105 110 115
acc ctg atg atc tac gta gcg atc ttc cgc caa aaa 487
Thr Leu Met Ile Tyr Val Ala Ile Phe Arg Gln Lys
120 125
<210> 420
<211> 129
<212> PRT
<213> Corynebacterium glutamicum
<400> 420
Met Arg Val Val Leu Phe Leu Ala Val Leu Gly Val Val Ala Gly Gly
1 5 10 15
Val Thr Leu Ser Thr Thr Gly Asn Pro Ala Ala Glu Ala Phe Gln His
20 25 30
Ala Ala Gly Asp Ile Gly Leu Arg Ile Phe Gly Ala Val Leu Trp Ala
35 40 45
Ala Ser Ile Ser Ser Val Ile Gly Ala Ser Tyr Thr Ser Ala Thr Phe
50 55 60
Leu Val Glu Asn Lys Pro Glu Lys Lys Arg Leu Gln Asn Trp Val Thr
65 70 75 80
Ile Ile Phe Ile Leu Ile Ser Cys Ser Val Phe Ile Met Leu Gly Thr
85 90 95
Ala Pro Ala Ile Leu Leu Val Phe Ala Gly Ala Phe Asn Gly Leu Val
100 105 110
Leu Pro Val Gly Phe Thr Leu Met Ile Tyr Val Ala Ile Phe Arg Gln
115 120 125
Lys
<210> 421
<211> 490
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(490)
<223> FRXA01538
<400> 421
tctaaactca ctctcaactc accaagattg ttcaacaatc tgcgattggt gtgcaatcta 60
ccccaatcat tttgaaagcc cccacgaaag gagcgcgaca atg gcc gac aac aaa 115
Met Ala Asp Asn Lys
1 5
aat gcc gat gac agc cag cta gtc tca gcc agc act gga acc cct ggg 163
Asn Ala Asp Asp Ser Gln Leu Val Ser Ala Ser Thr Gly Thr Pro Gly
10 15 20
cct ggc gac att gca aaa gcc aat gcg cca tcc ctc aag caa gct gca 211
Pro Gly Asp Ile Ala Lys Ala Asn Ala Pro Ser Leu Lys Gln Ala Ala
25 30 35
gta acc gcc tct ggc cga agc gct ctg atg ggt gcc atc ttc ctc atg 259
Val Thr Ala Ser Gly Arg Ser Ala Leu Met Gly Ala Ile Phe Leu Met
40 45 50
gca act tct gcc atc ggc cca ggg ttc ctc acc caa acc gct gtc ttc 307
Ala Thr Ser Ala Ile Gly Pro Gly Phe Leu Thr Gln Thr Ala Val Phe
55 60 65
acc aac cag ctc ggc gca gct ttc gca ttt gcg atc ctg gtg tcg atc 355
Thr Asn Gln Leu Gly Ala Ala Phe Ala Phe Ala Ile Leu Val Ser Ile
70 75 80 85
ctc att gac atc gcg gtg cag ctg aat gtg tgg cgc atc atc ggc gtc 403
Leu Ile Asp Ile Ala Val Gln Leu Asn Val Trp Arg Ile Ile Gly Val
90 95 100
tct gaa atg cgc gcc caa gaa ctc ggc aac acg gtt atc cca ggt ttt 451
Ser Glu Met Arg Ala Gln Glu Leu Gly Asn Thr Val Ile Pro Gly Phe
105 110 115
ggt tgg gtg ctg gcc gta ctg gtc tgt att ggc ggc gta 490
Gly Trp Val Leu Ala Val Leu Val Cys Ile Gly Gly Val
120 125 130
<210> 422
<211> 130
<212> PRT
<213> Corynebacterium glutamicum
<400> 422
Met Ala Asp Asn Lys Asn Ala Asp Asp Ser Gln Leu Val Ser Ala Ser
1 5 10 15
Thr Gly Thr Pro Gly Pro Gly Asp Ile Ala Lys Ala Asn Ala Pro Ser
20 25 30
Leu Lys Gln Ala Ala Val Thr Ala Ser Gly Arg Ser Ala Leu Met Gly
35 40 45
Ala Ile Phe Leu Met Ala Thr Ser Ala Ile Gly Pro Gly Phe Leu Thr
50 55 60
Gln Thr Ala Val Phe Thr Asn Gln Leu Gly Ala Ala Phe Ala Phe Ala
65 70 75 80
Ile Leu Val Ser Ile Leu Ile Asp Ile Ala Val Gln Leu Asn Val Trp
85 90 95
Arg Ile Ile Gly Val Ser Glu Met Arg Ala Gln Glu Leu Gly Asn Thr
100 105 110
Val Ile Pro Gly Phe Gly Trp Val Leu Ala Val Leu Val Cys Ile Gly
115 120 125
Gly Val
130
<210> 423
<211> 1401
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1378)
<223> RXA01727
<400> 423
agcttttggt ggtttcacca cctgcgctcg tcttaatttt gcgtgttcca gagagaccct 60
tgaggagggg ctgcgccgta tcgccagcgt gttgtaaata atg agt aaa aag tct 115
Met Ser Lys Lys Ser
1 5
gtc ctg att act tct ttg atg ctg ttt tcc atg ttc ttc gga gct gga 163
Val Leu Ile Thr Ser Leu Met Leu Phe Ser Met Phe Phe Gly Ala Gly
10 15 20
aac ctc atc ttc ccg ccg atg ctt gga ttg tcg gca gga acc aac tat 211
Asn Leu Ile Phe Pro Pro Met Leu Gly Leu Ser Ala Gly Thr Asn Tyr
25 30 35
cta cca gct atc tta gga ttt cta gca acg agt gtt ctg ctc ccg gtg 259
Leu Pro Ala Ile Leu Gly Phe Leu Ala Thr Ser Val Leu Leu Pro Val
40 45 50
ctg gcg att atc gcg gtg gtg ttg tcg gga gaa aat gtc aag gac atg 307
Leu Ala Ile Ile Ala Val Val Leu Ser Gly Glu Asn Val Lys Asp Met
55 60 65
gct tct cgt ggc ggt aag atc ttt ggc ctg gtg ttt cct att gct gcc 355
Ala Ser Arg Gly Gly Lys Ile Phe Gly Leu Val Phe Pro Ile Ala Ala
70 75 80 85
tat ttg tct atc ggc gcg ttt tac gcg ctg ccg agg act ggg gcg gtg 403
Tyr Leu Ser Ile Gly Ala Phe Tyr Ala Leu Pro Arg Thr Gly Ala Val
90 95 100
agc tat tcg acg gcg gtt ggc gtc gat aat gcg ctt tat tcg ggc ttg 451
Ser Tyr Ser Thr Ala Val Gly Val Asp Asn Ala Leu Tyr Ser Gly Leu
105 110 115
ttt aac ttt gtg ttt ttt gcg gtg gca ctg gcg ttg tcg tgg aat ccg 499
Phe Asn Phe Val Phe Phe Ala Val Ala Leu Ala Leu Ser Trp Asn Pro
120 125 130
aat ggc att gca gac aag ttg ggt aag tgg ctc acg cca gcg ttg ctc 547
Asn Gly Ile Ala Asp Lys Leu Gly Lys Trp Leu Thr Pro Ala Leu Leu
135 140 145
acg ttg att gtg gtg ctg gtg gtg ttg tcg gta gcc aag ttg gat ggc 595
Thr Leu Ile Val Val Leu Val Val Leu Ser Val Ala Lys Leu Asp Gly
150 155 160 165
acg cca ggt gag cca agt agt gcg tat gcg cag cag cct gcg ggg gcg 643
Thr Pro Gly Glu Pro Ser Ser Ala Tyr Ala Gln Gln Pro Ala Gly Ala
170 175 180
ggt ttg ctt gag ggc tac atg acg atg gat gcg att gct gcg ttg gcg 691
Gly Leu Leu Glu Gly Tyr Met Thr Met Asp Ala Ile Ala Ala Leu Ala
185 190 195
ttt ggc atc gtg gtg att tct gcg ttc aag tac caa aag gtt aac aag 739
Phe Gly Ile Val Val Ile Ser Ala Phe Lys Tyr Gln Lys Val Asn Lys
200 205 210
gtc cgc acg gca act gtc gtg tcg gcg ttc att gcc gga att ttg ttg 787
Val Arg Thr Ala Thr Val Val Ser Ala Phe Ile Ala Gly Ile Leu Leu
215 220 225
gcg ctg gtt tat ctt ggt ttg ggc tca atc ggt caa gta gta aac ggt 835
Ala Leu Val Tyr Leu Gly Leu Gly Ser Ile Gly Gln Val Val Asn Gly
230 235 240 245
gag ttc gct gat ggc acc gca att ttg aac tac gct gca ctg tcc acg 883
Glu Phe Ala Asp Gly Thr Ala Ile Leu Asn Tyr Ala Ala Leu Ser Thr
250 255 260
atg ggt cag gct ggt cgc atc atg ttc gtg gct att ttg atc ctt gca 931
Met Gly Gln Ala Gly Arg Ile Met Phe Val Ala Ile Leu Ile Leu Ala
265 270 275
tgt atg acc acc gca gtt ggt ctg atc agt gcg acg tct gag ttt ttc 979
Cys Met Thr Thr Ala Val Gly Leu Ile Ser Ala Thr Ser Glu Phe Phe
280 285 290
aat tcg ctg ctg cca ggt gtc aag tac cac gtc tgg gcc act gtt ttc 1027
Asn Ser Leu Leu Pro Gly Val Lys Tyr His Val Trp Ala Thr Val Phe
295 300 305
gcg ctg att tcc ttt ggc gtt gcc acc atg ggt ttg gat acg gtg ttg 1075
Ala Leu Ile Ser Phe Gly Val Ala Thr Met Gly Leu Asp Thr Val Leu
310 315 320 325
gcc gtt gcg gct cca gtg att agt ttc att tac cca tcg gcc atc acc 1123
Ala Val Ala Ala Pro Val Ile Ser Phe Ile Tyr Pro Ser Ala Ile Thr
330 335 340
ttg gtg ttc ttg tcg ctc atc gag ccc ctg ctg ttc cgt ctc aag tgg 1171
Leu Val Phe Leu Ser Leu Ile Glu Pro Leu Leu Phe Arg Leu Lys Trp
345 350 355
acc tac cta ttc ggc att tgg act gca gtt gtg tgg gcg ctg ttc atg 1219
Thr Tyr Leu Phe Gly Ile Trp Thr Ala Val Val Trp Ala Leu Phe Met
360 365 370
tct atc cct gcg ctg aat cca ttc atc gaa tgg gcg ccg ctg cac agc 1267
Ser Ile Pro Ala Leu Asn Pro Phe Ile Glu Trp Ala Pro Leu His Ser
375 380 385
atg tct ttg ggt tgg gtt gtc cca gtt ctc gtg gcc tct gcc atc ggt 1315
Met Ser Leu Gly Trp Val Val Pro Val Leu Val Ala Ser Ala Ile Gly
390 395 400 405
ttg gct att gat tgg aac aag aaa ggt gcc cag tct gtt gca aag aag 1363
Leu Ala Ile Asp Trp Asn Lys Lys Gly Ala Gln Ser Val Ala Lys Lys
410 415 420
gaa tcc att tcc gtc taatcgctaa ttgcgaggag tct 1401
Glu Ser Ile Ser Val
425
<210> 424
<211> 426
<212> PRT
<213> Corynebacterium glutamicum
<400> 424
Met Ser Lys Lys Ser Val Leu Ile Thr Ser Leu Met Leu Phe Ser Met
1 5 10 15
Phe Phe Gly Ala Gly Asn Leu Ile Phe Pro Pro Met Leu Gly Leu Ser
20 25 30
Ala Gly Thr Asn Tyr Leu Pro Ala Ile Leu Gly Phe Leu Ala Thr Ser
35 40 45
Val Leu Leu Pro Val Leu Ala Ile Ile Ala Val Val Leu Ser Gly Glu
50 55 60
Asn Val Lys Asp Met Ala Ser Arg Gly Gly Lys Ile Phe Gly Leu Val
65 70 75 80
Phe Pro Ile Ala Ala Tyr Leu Ser Ile Gly Ala Phe Tyr Ala Leu Pro
85 90 95
Arg Thr Gly Ala Val Ser Tyr Ser Thr Ala Val Gly Val Asp Asn Ala
100 105 110
Leu Tyr Ser Gly Leu Phe Asn Phe Val Phe Phe Ala Val Ala Leu Ala
115 120 125
Leu Ser Trp Asn Pro Asn Gly Ile Ala Asp Lys Leu Gly Lys Trp Leu
130 135 140
Thr Pro Ala Leu Leu Thr Leu Ile Val Val Leu Val Val Leu Ser Val
145 150 155 160
Ala Lys Leu Asp Gly Thr Pro Gly Glu Pro Ser Ser Ala Tyr Ala Gln
165 170 175
Gln Pro Ala Gly Ala Gly Leu Leu Glu Gly Tyr Met Thr Met Asp Ala
180 185 190
Ile Ala Ala Leu Ala Phe Gly Ile Val Val Ile Ser Ala Phe Lys Tyr
195 200 205
Gln Lys Val Asn Lys Val Arg Thr Ala Thr Val Val Ser Ala Phe Ile
210 215 220
Ala Gly Ile Leu Leu Ala Leu Val Tyr Leu Gly Leu Gly Ser Ile Gly
225 230 235 240
Gln Val Val Asn Gly Glu Phe Ala Asp Gly Thr Ala Ile Leu Asn Tyr
245 250 255
Ala Ala Leu Ser Thr Met Gly Gln Ala Gly Arg Ile Met Phe Val Ala
260 265 270
Ile Leu Ile Leu Ala Cys Met Thr Thr Ala Val Gly Leu Ile Ser Ala
275 280 285
Thr Ser Glu Phe Phe Asn Ser Leu Leu Pro Gly Val Lys Tyr His Val
290 295 300
Trp Ala Thr Val Phe Ala Leu Ile Ser Phe Gly Val Ala Thr Met Gly
305 310 315 320
Leu Asp Thr Val Leu Ala Val Ala Ala Pro Val Ile Ser Phe Ile Tyr
325 330 335
Pro Ser Ala Ile Thr Leu Val Phe Leu Ser Leu Ile Glu Pro Leu Leu
340 345 350
Phe Arg Leu Lys Trp Thr Tyr Leu Phe Gly Ile Trp Thr Ala Val Val
355 360 365
Trp Ala Leu Phe Met Ser Ile Pro Ala Leu Asn Pro Phe Ile Glu Trp
370 375 380
Ala Pro Leu His Ser Met Ser Leu Gly Trp Val Val Pro Val Leu Val
385 390 395 400
Ala Ser Ala Ile Gly Leu Ala Ile Asp Trp Asn Lys Lys Gly Ala Gln
405 410 415
Ser Val Ala Lys Lys Glu Ser Ile Ser Val
420 425
<210> 425
<211> 1461
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1438)
<223> RXA00623
<400> 425
tttaagcttc gtcggcaacg atcacaccac gttaaatttc gaccatcaat gacggtggcc 60
gttttttggc gaatccccaa aaaggtcgaa gaggaagttc atg gat tca aac aca 115
Met Asp Ser Asn Thr
1 5
gaa tct tca agt gtt gag gtc aaa aac gaa cac att aaa gtt caa aag 163
Glu Ser Ser Ser Val Glu Val Lys Asn Glu His Ile Lys Val Gln Lys
10 15 20
ccg ccg aag aag gac cgc act cac tgg ctc tac att gcg gtc att atc 211
Pro Pro Lys Lys Asp Arg Thr His Trp Leu Tyr Ile Ala Val Ile Ile
25 30 35
gca ttg att ggc ggt att acc cta ggc ctg att tca ccg gag ttg ggc 259
Ala Leu Ile Gly Gly Ile Thr Leu Gly Leu Ile Ser Pro Glu Leu Gly
40 45 50
aaa gaa ttc aag att ttg ggc acc atg ttt gtg tcc ttg atc aag atg 307
Lys Glu Phe Lys Ile Leu Gly Thr Met Phe Val Ser Leu Ile Lys Met
55 60 65
att atc gct cca gtt att ttc tgc acc atc gtc atc gga atc ggt tca 355
Ile Ile Ala Pro Val Ile Phe Cys Thr Ile Val Ile Gly Ile Gly Ser
70 75 80 85
gtc aag gca gcg gca aca gtc gga cgc gct ggt ggc atc gcc ctt gcg 403
Val Lys Ala Ala Ala Thr Val Gly Arg Ala Gly Gly Ile Ala Leu Ala
90 95 100
tac ttc atc acg atg tcc aca ttc gca ctc gca gtt ggc ctg cta gtc 451
Tyr Phe Ile Thr Met Ser Thr Phe Ala Leu Ala Val Gly Leu Leu Val
105 110 115
ggt aac ttc atc cag cca ggt agc gga ctg aac atc tca gtt gat gaa 499
Gly Asn Phe Ile Gln Pro Gly Ser Gly Leu Asn Ile Ser Val Asp Glu
120 125 130
gaa tct tca ttc gca tcc aca gag agc agc cct gaa gga ctc ttg gga 547
Glu Ser Ser Phe Ala Ser Thr Glu Ser Ser Pro Glu Gly Leu Leu Gly
135 140 145
ttc atc cac tcg atc atc cct gaa acg ttc ttc tct gca ttt act gat 595
Phe Ile His Ser Ile Ile Pro Glu Thr Phe Phe Ser Ala Phe Thr Asp
150 155 160 165
ggt tcg gtg ctg cag gta ctg ttc atc gcc atc ctc gtg ggc ttt gca 643
Gly Ser Val Leu Gln Val Leu Phe Ile Ala Ile Leu Val Gly Phe Ala
170 175 180
gct cag tcg atg ggt gaa aag gga cag ccc atc ctt gat ttc gta tcc 691
Ala Gln Ser Met Gly Glu Lys Gly Gln Pro Ile Leu Asp Phe Val Ser
185 190 195
cat ctg cag aag ctc atc ttc aag att ttg aac tgg att ctg tgg ctc 739
His Leu Gln Lys Leu Ile Phe Lys Ile Leu Asn Trp Ile Leu Trp Leu
200 205 210
gcc cca gtc ggt gca ttc ggt gca atg gcc ggc gtc gtt ggc gaa aca 787
Ala Pro Val Gly Ala Phe Gly Ala Met Ala Gly Val Val Gly Glu Thr
215 220 225
ggc ttt gat gcc gtt gtt cag ctc ggt att ttg atc ctc gcc ttt tac 835
Gly Phe Asp Ala Val Val Gln Leu Gly Ile Leu Ile Leu Ala Phe Tyr
230 235 240 245
gtc acc tgc gtg atc ttc atc ttt ggc gtg ctg ggc gcc gta ctg aag 883
Val Thr Cys Val Ile Phe Ile Phe Gly Val Leu Gly Ala Val Leu Lys
250 255 260
gtg ttc acc ggc gtg aat atc ttc aag ctg gtc aag tac ctt gcc aag 931
Val Phe Thr Gly Val Asn Ile Phe Lys Leu Val Lys Tyr Leu Ala Lys
265 270 275
gaa ttc ctg ctg atc ttt gct acc tca tcc tct gaa tct gcc ttg cca 979
Glu Phe Leu Leu Ile Phe Ala Thr Ser Ser Ser Glu Ser Ala Leu Pro
280 285 290
aac ctc atg cgc aag atg gaa cac atc ggt gtg gct aaa cca acc gtc 1027
Asn Leu Met Arg Lys Met Glu His Ile Gly Val Ala Lys Pro Thr Val
295 300 305
gga atc gtg gtc cca acc ggc tat tcc ttc aac ttg gac ggc acc gca 1075
Gly Ile Val Val Pro Thr Gly Tyr Ser Phe Asn Leu Asp Gly Thr Ala
310 315 320 325
att tac ctc acc atg gca tct atc ttc att gcc gac gcg atg aat atg 1123
Ile Tyr Leu Thr Met Ala Ser Ile Phe Ile Ala Asp Ala Met Asn Met
330 335 340
ccg atg agc ctc ggc gag cag gtc ggt ctg ctt gtc ttc atg atc atc 1171
Pro Met Ser Leu Gly Glu Gln Val Gly Leu Leu Val Phe Met Ile Ile
345 350 355
gca tcc aag ggc gct gct ggt gtc tcg ggt gcc ggt att gca acg ttg 1219
Ala Ser Lys Gly Ala Ala Gly Val Ser Gly Ala Gly Ile Ala Thr Leu
360 365 370
gct gcc gga ttg tct tca cac cgc cca gaa ctt ctg cac ggc gtt gac 1267
Ala Ala Gly Leu Ser Ser His Arg Pro Glu Leu Leu His Gly Val Asp
375 380 385
gtg att gtg ggc atc gat aaa ttc atg tct gaa gcc cgc gca cta acc 1315
Val Ile Val Gly Ile Asp Lys Phe Met Ser Glu Ala Arg Ala Leu Thr
390 395 400 405
aac ttc gcc gga aac tcc gtg gca aca ctg ctg gtc ggc aag tgg act 1363
Asn Phe Ala Gly Asn Ser Val Ala Thr Leu Leu Val Gly Lys Trp Thr
410 415 420
ggc acc gtg gac atg aac caa gtc cat gac gtt ttg aat gga aaa tct 1411
Gly Thr Val Asp Met Asn Gln Val His Asp Val Leu Asn Gly Lys Ser
425 430 435
cca ttt gtg gag tta gaa gaa gac cac tagttttcaa caggacgaca 1458
Pro Phe Val Glu Leu Glu Glu Asp His
440 445
acg 1461
<210> 426
<211> 446
<212> PRT
<213> Corynebacterium glutamicum
<400> 426
Met Asp Ser Asn Thr Glu Ser Ser Ser Val Glu Val Lys Asn Glu His
1 5 10 15
Ile Lys Val Gln Lys Pro Pro Lys Lys Asp Arg Thr His Trp Leu Tyr
20 25 30
Ile Ala Val Ile Ile Ala Leu Ile Gly Gly Ile Thr Leu Gly Leu Ile
35 40 45
Ser Pro Glu Leu Gly Lys Glu Phe Lys Ile Leu Gly Thr Met Phe Val
50 55 60
Ser Leu Ile Lys Met Ile Ile Ala Pro Val Ile Phe Cys Thr Ile Val
65 70 75 80
Ile Gly Ile Gly Ser Val Lys Ala Ala Ala Thr Val Gly Arg Ala Gly
85 90 95
Gly Ile Ala Leu Ala Tyr Phe Ile Thr Met Ser Thr Phe Ala Leu Ala
100 105 110
Val Gly Leu Leu Val Gly Asn Phe Ile Gln Pro Gly Ser Gly Leu Asn
115 120 125
Ile Ser Val Asp Glu Glu Ser Ser Phe Ala Ser Thr Glu Ser Ser Pro
130 135 140
Glu Gly Leu Leu Gly Phe Ile His Ser Ile Ile Pro Glu Thr Phe Phe
145 150 155 160
Ser Ala Phe Thr Asp Gly Ser Val Leu Gln Val Leu Phe Ile Ala Ile
165 170 175
Leu Val Gly Phe Ala Ala Gln Ser Met Gly Glu Lys Gly Gln Pro Ile
180 185 190
Leu Asp Phe Val Ser His Leu Gln Lys Leu Ile Phe Lys Ile Leu Asn
195 200 205
Trp Ile Leu Trp Leu Ala Pro Val Gly Ala Phe Gly Ala Met Ala Gly
210 215 220
Val Val Gly Glu Thr Gly Phe Asp Ala Val Val Gln Leu Gly Ile Leu
225 230 235 240
Ile Leu Ala Phe Tyr Val Thr Cys Val Ile Phe Ile Phe Gly Val Leu
245 250 255
Gly Ala Val Leu Lys Val Phe Thr Gly Val Asn Ile Phe Lys Leu Val
260 265 270
Lys Tyr Leu Ala Lys Glu Phe Leu Leu Ile Phe Ala Thr Ser Ser Ser
275 280 285
Glu Ser Ala Leu Pro Asn Leu Met Arg Lys Met Glu His Ile Gly Val
290 295 300
Ala Lys Pro Thr Val Gly Ile Val Val Pro Thr Gly Tyr Ser Phe Asn
305 310 315 320
Leu Asp Gly Thr Ala Ile Tyr Leu Thr Met Ala Ser Ile Phe Ile Ala
325 330 335
Asp Ala Met Asn Met Pro Met Ser Leu Gly Glu Gln Val Gly Leu Leu
340 345 350
Val Phe Met Ile Ile Ala Ser Lys Gly Ala Ala Gly Val Ser Gly Ala
355 360 365
Gly Ile Ala Thr Leu Ala Ala Gly Leu Ser Ser His Arg Pro Glu Leu
370 375 380
Leu His Gly Val Asp Val Ile Val Gly Ile Asp Lys Phe Met Ser Glu
385 390 395 400
Ala Arg Ala Leu Thr Asn Phe Ala Gly Asn Ser Val Ala Thr Leu Leu
405 410 415
Val Gly Lys Trp Thr Gly Thr Val Asp Met Asn Gln Val His Asp Val
420 425 430
Leu Asn Gly Lys Ser Pro Phe Val Glu Leu Glu Glu Asp His
435 440 445
<210> 427
<211> 620
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (55)..(597)
<223> RXA01584
<400> 427
ccaccccctt ccccgctacg cgccataccg gcttgggcgg gcatcggatc acta gtg 57
Val
1
gtg ttt ttg ggc gca ctt ctc ggc gcc gta atc atg ggc ggg ttt tat 105
Val Phe Leu Gly Ala Leu Leu Gly Ala Val Ile Met Gly Gly Phe Tyr
5 10 15
cca gca ttc att caa gcc gga tcc aca gtg ttc ggc ggc ggc cac gtg 153
Pro Ala Phe Ile Gln Ala Gly Ser Thr Val Phe Gly Gly Gly His Val
20 25 30
gtt ttg cca ctg ctg gaa aag ctc gtt gtt gcg ccc ggt ttt att aaa 201
Val Leu Pro Leu Leu Glu Lys Leu Val Val Ala Pro Gly Phe Ile Lys
35 40 45
gaa acc gac ttc cta tcc ggc tac tcc gca gcg cag gca gtg cct ggc 249
Glu Thr Asp Phe Leu Ser Gly Tyr Ser Ala Ala Gln Ala Val Pro Gly
50 55 60 65
ccc atg ttc agc ttc gcc agc tac ctc ggc gca atc tac ggt ggc atc 297
Pro Met Phe Ser Phe Ala Ser Tyr Leu Gly Ala Ile Tyr Gly Gly Ile
70 75 80
ggt ggt gca gtg ctg gcc agc ctg gcg atc ttc ttc ccc gcc gca ctc 345
Gly Gly Ala Val Leu Ala Ser Leu Ala Ile Phe Phe Pro Ala Ala Leu
85 90 95
ttg agc atc agc gga atg tac ttt tgg gga cgc tgg cga aaa gca ccg 393
Leu Ser Ile Ser Gly Met Tyr Phe Trp Gly Arg Trp Arg Lys Ala Pro
100 105 110
cgc atc caa gca gca gtc acc ggc atc aac gcc ggt gtg gtg ggg ctt 441
Arg Ile Gln Ala Ala Val Thr Gly Ile Asn Ala Gly Val Val Gly Leu
115 120 125
ttg ggc gca gcg ctc tac gat ccc gta ttc acc cac ggc atc acc agc 489
Leu Gly Ala Ala Leu Tyr Asp Pro Val Phe Thr His Gly Ile Thr Ser
130 135 140 145
gtt tcc gca tta gct atc gca acg gtg tgt tgg ctg ggg cta gcc cac 537
Val Ser Ala Leu Ala Ile Ala Thr Val Cys Trp Leu Gly Leu Ala His
150 155 160
tgg aaa att ccg ccg tgg gcc atc gcc gcg ggt gcg gcc ctt gca ggc 585
Trp Lys Ile Pro Pro Trp Ala Ile Ala Ala Gly Ala Ala Leu Ala Gly
165 170 175
tgg gtc ttg ctt tagaaaacgc tcagacccaa acc 620
Trp Val Leu Leu
180
<210> 428
<211> 181
<212> PRT
<213> Corynebacterium glutamicum
<400> 428
Val Val Phe Leu Gly Ala Leu Leu Gly Ala Val Ile Met Gly Gly Phe
1 5 10 15
Tyr Pro Ala Phe Ile Gln Ala Gly Ser Thr Val Phe Gly Gly Gly His
20 25 30
Val Val Leu Pro Leu Leu Glu Lys Leu Val Val Ala Pro Gly Phe Ile
35 40 45
Lys Glu Thr Asp Phe Leu Ser Gly Tyr Ser Ala Ala Gln Ala Val Pro
50 55 60
Gly Pro Met Phe Ser Phe Ala Ser Tyr Leu Gly Ala Ile Tyr Gly Gly
65 70 75 80
Ile Gly Gly Ala Val Leu Ala Ser Leu Ala Ile Phe Phe Pro Ala Ala
85 90 95
Leu Leu Ser Ile Ser Gly Met Tyr Phe Trp Gly Arg Trp Arg Lys Ala
100 105 110
Pro Arg Ile Gln Ala Ala Val Thr Gly Ile Asn Ala Gly Val Val Gly
115 120 125
Leu Leu Gly Ala Ala Leu Tyr Asp Pro Val Phe Thr His Gly Ile Thr
130 135 140
Ser Val Ser Ala Leu Ala Ile Ala Thr Val Cys Trp Leu Gly Leu Ala
145 150 155 160
His Trp Lys Ile Pro Pro Trp Ala Ile Ala Ala Gly Ala Ala Leu Ala
165 170 175
Gly Trp Val Leu Leu
180
<210> 429
<211> 813
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(790)
<223> RXA00852
<400> 429
agatcaccgt catggtcata atcgccgctg gagttcatgc agcattccct gacatccgta 60
agaaatagtt ccaacccact tttcctcaga attgcagttc atg ccc gag atc att 115
Met Pro Glu Ile Ile
1 5
ttt gac aac act gaa gta cgc tac gat gac tcg ctc att tta gag ccc 163
Phe Asp Asn Thr Glu Val Arg Tyr Asp Asp Ser Leu Ile Leu Glu Pro
10 15 20
cta tcg tta aaa ctg aca gaa caa cgc att ggc atc atc ggg gct aac 211
Leu Ser Leu Lys Leu Thr Glu Gln Arg Ile Gly Ile Ile Gly Ala Asn
25 30 35
ggc ggt gga aaa tcc acg ctc atc aga atg atc aat ggt ctc ggc gaa 259
Gly Gly Gly Lys Ser Thr Leu Ile Arg Met Ile Asn Gly Leu Gly Glu
40 45 50
cca acc aca ggg cgt gtt cta gtt gat ggc ctt gac gtc tcg cat tcc 307
Pro Thr Thr Gly Arg Val Leu Val Asp Gly Leu Asp Val Ser His Ser
55 60 65
gga cgg gaa gtt cgc aag aag gtt gga ttt gtc ttc tct gac gct gaa 355
Gly Arg Glu Val Arg Lys Lys Val Gly Phe Val Phe Ser Asp Ala Glu
70 75 80 85
aac cag atc gtg atg cca act gtg cgt gag gat att gcc ttc tcg ctt 403
Asn Gln Ile Val Met Pro Thr Val Arg Glu Asp Ile Ala Phe Ser Leu
90 95 100
cgc cgg cac aaa atg cca cgc gct gaa aag gcg caa cgt gtc gac gag 451
Arg Arg His Lys Met Pro Arg Ala Glu Lys Ala Gln Arg Val Asp Glu
105 110 115
atg atg gcg cga ttc aac ttg agc gag cat gca gat caa tca ccg cac 499
Met Met Ala Arg Phe Asn Leu Ser Glu His Ala Asp Gln Ser Pro His
120 125 130
acc cta tcc ggt ggt caa aag cag ttg tta gcg ctg gct gca gta ctg 547
Thr Leu Ser Gly Gly Gln Lys Gln Leu Leu Ala Leu Ala Ala Val Leu
135 140 145
att ttg gag cca gaa gtg atc atc gct gat gag ccc act acc ctg ctg 595
Ile Leu Glu Pro Glu Val Ile Ile Ala Asp Glu Pro Thr Thr Leu Leu
150 155 160 165
gat ctg cgc aat agg ctg atg atc aaa gac gtg ttc aat aaa ctc gag 643
Asp Leu Arg Asn Arg Leu Met Ile Lys Asp Val Phe Asn Lys Leu Glu
170 175 180
cag caa tta atc gtt gtc agc cat gat tta gat ttc ctc agc gat ttt 691
Gln Gln Leu Ile Val Val Ser His Asp Leu Asp Phe Leu Ser Asp Phe
185 190 195
gag cgg gtc att tgc atc aat gat cat aaa atc gct gct gat ggc cct 739
Glu Arg Val Ile Cys Ile Asn Asp His Lys Ile Ala Ala Asp Gly Pro
200 205 210
ccg caa aag tcc att gac ctg tac gta tcg ctt atg gcg gaa cct gcg 787
Pro Gln Lys Ser Ile Asp Leu Tyr Val Ser Leu Met Ala Glu Pro Ala
215 220 225
aaa tgaacagtat tcctttaggt ttt 813
Lys
230
<210> 430
<211> 230
<212> PRT
<213> Corynebacterium glutamicum
<400> 430
Met Pro Glu Ile Ile Phe Asp Asn Thr Glu Val Arg Tyr Asp Asp Ser
1 5 10 15
Leu Ile Leu Glu Pro Leu Ser Leu Lys Leu Thr Glu Gln Arg Ile Gly
20 25 30
Ile Ile Gly Ala Asn Gly Gly Gly Lys Ser Thr Leu Ile Arg Met Ile
35 40 45
Asn Gly Leu Gly Glu Pro Thr Thr Gly Arg Val Leu Val Asp Gly Leu
50 55 60
Asp Val Ser His Ser Gly Arg Glu Val Arg Lys Lys Val Gly Phe Val
65 70 75 80
Phe Ser Asp Ala Glu Asn Gln Ile Val Met Pro Thr Val Arg Glu Asp
85 90 95
Ile Ala Phe Ser Leu Arg Arg His Lys Met Pro Arg Ala Glu Lys Ala
100 105 110
Gln Arg Val Asp Glu Met Met Ala Arg Phe Asn Leu Ser Glu His Ala
115 120 125
Asp Gln Ser Pro His Thr Leu Ser Gly Gly Gln Lys Gln Leu Leu Ala
130 135 140
Leu Ala Ala Val Leu Ile Leu Glu Pro Glu Val Ile Ile Ala Asp Glu
145 150 155 160
Pro Thr Thr Leu Leu Asp Leu Arg Asn Arg Leu Met Ile Lys Asp Val
165 170 175
Phe Asn Lys Leu Glu Gln Gln Leu Ile Val Val Ser His Asp Leu Asp
180 185 190
Phe Leu Ser Asp Phe Glu Arg Val Ile Cys Ile Asn Asp His Lys Ile
195 200 205
Ala Ala Asp Gly Pro Pro Gln Lys Ser Ile Asp Leu Tyr Val Ser Leu
210 215 220
Met Ala Glu Pro Ala Lys
225 230
<210> 431
<211> 1269
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1246)
<223> RXA00690
<400> 431
atggatcatt ggactcacac tggctgtcat ttccttggtt tcagcgtctg ctgtggcggc 60
gtgggcgatt cgtcgttcag aggtccaggg ttaaagcttc gtg aaa tgg att gag 115
Val Lys Trp Ile Glu
1 5
cga tat gtg ctg tcc cgg cgg atg gtt cat ccc tgg gcg tgg tgg gtg 163
Arg Tyr Val Leu Ser Arg Arg Met Val His Pro Trp Ala Trp Trp Val
10 15 20
tgg gcg ttg ggt att gct ggt tgt gcc agc atg acc aac aat cct tat 211
Trp Ala Leu Gly Ile Ala Gly Cys Ala Ser Met Thr Asn Asn Pro Tyr
25 30 35
att ttg gcg ctc act ttt gcc acg ttg tgt ttt gtg gtg ttt aac cgt 259
Ile Leu Ala Leu Thr Phe Ala Thr Leu Cys Phe Val Val Phe Asn Arg
40 45 50
cgt ggg tca tcg ccg tgg tcg cgt gct ttc ccg atc tat ttg atg atc 307
Arg Gly Ser Ser Pro Trp Ser Arg Ala Phe Pro Ile Tyr Leu Met Ile
55 60 65
gcg ggt tgg ctc gtg gtg tac cgg ttg gtc atg cac att gtg gtg gga 355
Ala Gly Trp Leu Val Val Tyr Arg Leu Val Met His Ile Val Val Gly
70 75 80 85
gca aaa att ggc acc att gaa ctg ttt cgg atc ccg ccg gtg cag ttg 403
Ala Lys Ile Gly Thr Ile Glu Leu Phe Arg Ile Pro Pro Val Gln Leu
90 95 100
ccg gaa tgg gct gcg ggt atc cac gtg ttt ggc acg gtg tat ctc gag 451
Pro Glu Trp Ala Ala Gly Ile His Val Phe Gly Thr Val Tyr Leu Glu
105 110 115
ggt ctg atc atc gcg acg acg caa ggc tta acg ctt gga acg atg atc 499
Gly Leu Ile Ile Ala Thr Thr Gln Gly Leu Thr Leu Gly Thr Met Ile
120 125 130
gtg gcg gtg ggt gct gcg aac tct ttg gcg gat ccc aag aag ctg ctc 547
Val Ala Val Gly Ala Ala Asn Ser Leu Ala Asp Pro Lys Lys Leu Leu
135 140 145
aaa tcg ttg cct ggc gca ttg ggc gaa ctg gga act gcg gtg gtc atc 595
Lys Ser Leu Pro Gly Ala Leu Gly Glu Leu Gly Thr Ala Val Val Ile
150 155 160 165
ggt att tcc att gca cct cag atg gct gag tcg gcg ttc cgc att aat 643
Gly Ile Ser Ile Ala Pro Gln Met Ala Glu Ser Ala Phe Arg Ile Asn
170 175 180
cgt gca cga acc ttg cgt ggt gat gat gcc aaa ggt gtt cgt ggt ttc 691
Arg Ala Arg Thr Leu Arg Gly Asp Asp Ala Lys Gly Val Arg Gly Phe
185 190 195
gcg cgg att ttg atg ccg gtt ttc cag gac act ttg gat agg tct ttg 739
Ala Arg Ile Leu Met Pro Val Phe Gln Asp Thr Leu Asp Arg Ser Leu
200 205 210
gcc ctg gct aat tcc atg gat gcc cgt ggt tat ggc agg cag gct cat 787
Ala Leu Ala Asn Ser Met Asp Ala Arg Gly Tyr Gly Arg Gln Ala His
215 220 225
gta tcc aaa ttc caa cag cgt gtg acc tct att ttt ggt gca ttc gga 835
Val Ser Lys Phe Gln Gln Arg Val Thr Ser Ile Phe Gly Ala Phe Gly
230 235 240 245
ata ctc ggc gtg acc gtt ggt ctg ttt gtg gtc tta gat gca tca tca 883
Ile Leu Gly Val Thr Val Gly Leu Phe Val Val Leu Asp Ala Ser Ser
250 255 260
ccg atg ttc gtt gcc gtt ccg gtg ttt att acc ggc gtg ggc ttc ttg 931
Pro Met Phe Val Ala Val Pro Val Phe Ile Thr Gly Val Gly Phe Leu
265 270 275
atc att tcg ttg gtc gtt gct tca cat aga aaa aca tcc acc act ttt 979
Ile Ile Ser Leu Val Val Ala Ser His Arg Lys Thr Ser Thr Thr Phe
280 285 290
gat cag ttg cct tgg ggt gct gcg gaa tgg ctt gtg tgc atc aca ggt 1027
Asp Gln Leu Pro Trp Gly Ala Ala Glu Trp Leu Val Cys Ile Thr Gly
295 300 305
gtg att ccg ctg ctc atg gct gcg ctg aca cga tac ctt gat cca ggt 1075
Val Ile Pro Leu Leu Met Ala Ala Leu Thr Arg Tyr Leu Asp Pro Gly
310 315 320 325
tcc atg atc acc acc tgg gtt cct ttg cat atg cca gac acc gtt ccg 1123
Ser Met Ile Thr Thr Trp Val Pro Leu His Met Pro Asp Thr Val Pro
330 335 340
ttg ctc gtt gtg gca gga ctt gtt gtg gcg acg atg cca gga ttc ttg 1171
Leu Leu Val Val Ala Gly Leu Val Val Ala Thr Met Pro Gly Phe Leu
345 350 355
acg ccc cgc ttg ccg aag aac aaa gtg agg gtc aag cgt cga aaa gca 1219
Thr Pro Arg Leu Pro Lys Asn Lys Val Arg Val Lys Arg Arg Lys Ala
360 365 370
ata aat agc cca gaa agg gcc gaa gtt taatgagtgc tccttttagc 1266
Ile Asn Ser Pro Glu Arg Ala Glu Val
375 380
gcg 1269
<210> 432
<211> 382
<212> PRT
<213> Corynebacterium glutamicum
<400> 432
Val Lys Trp Ile Glu Arg Tyr Val Leu Ser Arg Arg Met Val His Pro
1 5 10 15
Trp Ala Trp Trp Val Trp Ala Leu Gly Ile Ala Gly Cys Ala Ser Met
20 25 30
Thr Asn Asn Pro Tyr Ile Leu Ala Leu Thr Phe Ala Thr Leu Cys Phe
35 40 45
Val Val Phe Asn Arg Arg Gly Ser Ser Pro Trp Ser Arg Ala Phe Pro
50 55 60
Ile Tyr Leu Met Ile Ala Gly Trp Leu Val Val Tyr Arg Leu Val Met
65 70 75 80
His Ile Val Val Gly Ala Lys Ile Gly Thr Ile Glu Leu Phe Arg Ile
85 90 95
Pro Pro Val Gln Leu Pro Glu Trp Ala Ala Gly Ile His Val Phe Gly
100 105 110
Thr Val Tyr Leu Glu Gly Leu Ile Ile Ala Thr Thr Gln Gly Leu Thr
115 120 125
Leu Gly Thr Met Ile Val Ala Val Gly Ala Ala Asn Ser Leu Ala Asp
130 135 140
Pro Lys Lys Leu Leu Lys Ser Leu Pro Gly Ala Leu Gly Glu Leu Gly
145 150 155 160
Thr Ala Val Val Ile Gly Ile Ser Ile Ala Pro Gln Met Ala Glu Ser
165 170 175
Ala Phe Arg Ile Asn Arg Ala Arg Thr Leu Arg Gly Asp Asp Ala Lys
180 185 190
Gly Val Arg Gly Phe Ala Arg Ile Leu Met Pro Val Phe Gln Asp Thr
195 200 205
Leu Asp Arg Ser Leu Ala Leu Ala Asn Ser Met Asp Ala Arg Gly Tyr
210 215 220
Gly Arg Gln Ala His Val Ser Lys Phe Gln Gln Arg Val Thr Ser Ile
225 230 235 240
Phe Gly Ala Phe Gly Ile Leu Gly Val Thr Val Gly Leu Phe Val Val
245 250 255
Leu Asp Ala Ser Ser Pro Met Phe Val Ala Val Pro Val Phe Ile Thr
260 265 270
Gly Val Gly Phe Leu Ile Ile Ser Leu Val Val Ala Ser His Arg Lys
275 280 285
Thr Ser Thr Thr Phe Asp Gln Leu Pro Trp Gly Ala Ala Glu Trp Leu
290 295 300
Val Cys Ile Thr Gly Val Ile Pro Leu Leu Met Ala Ala Leu Thr Arg
305 310 315 320
Tyr Leu Asp Pro Gly Ser Met Ile Thr Thr Trp Val Pro Leu His Met
325 330 335
Pro Asp Thr Val Pro Leu Leu Val Val Ala Gly Leu Val Val Ala Thr
340 345 350
Met Pro Gly Phe Leu Thr Pro Arg Leu Pro Lys Asn Lys Val Arg Val
355 360 365
Lys Arg Arg Lys Ala Ile Asn Ser Pro Glu Arg Ala Glu Val
370 375 380
<210> 433
<211> 876
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(853)
<223> RXA00827
<400> 433
tgcgtgaatt aacagacaac ggaatcagca ttgtgtcagt aacccatgat cctgatttca 60
tcgcagcgct gggcgatcac cacattgagg tgagcgcgaa gtg aac ctg ctg atc 115
Val Asn Leu Leu Ile
1 5
aaa att aat ccc gtc acc cgc atc atc gcg ttg atg gta ctg acc acg 163
Lys Ile Asn Pro Val Thr Arg Ile Ile Ala Leu Met Val Leu Thr Thr
10 15 20
ccg ttg ctg ctg agt ttg gat gtg atg tcg gca gcg atc gcg ctg gtg 211
Pro Leu Leu Leu Ser Leu Asp Val Met Ser Ala Ala Ile Ala Leu Val
25 30 35
gca acc att att ctg gca cca ttt gcc ggc gtg acc tgg aag atg ctg 259
Ala Thr Ile Ile Leu Ala Pro Phe Ala Gly Val Thr Trp Lys Met Leu
40 45 50
ctg aaa cgt ggc tgg atg ctg ttc ctc atg gca ccg gtg gct gca tta 307
Leu Lys Arg Gly Trp Met Leu Phe Leu Met Ala Pro Val Ala Ala Leu
55 60 65
tcc atg gcg ctt tat ggc agg ccg gat gga aaa gag tac ttt agc ttc 355
Ser Met Ala Leu Tyr Gly Arg Pro Asp Gly Lys Glu Tyr Phe Ser Phe
70 75 80 85
ctg ctc att cac gtc act gat aat tca ctg gct ttg gct gct gcc att 403
Leu Leu Ile His Val Thr Asp Asn Ser Leu Ala Leu Ala Ala Ala Ile
90 95 100
ggg ctg cgt gtt ctg gcg att ggt ctg ccc gtt gtg gtg ctg att gct 451
Gly Leu Arg Val Leu Ala Ile Gly Leu Pro Val Val Val Leu Ile Ala
105 110 115
cgc att gat ccc acc gac ctg ggc gat ggt ttg gcg cag ctg ctc aaa 499
Arg Ile Asp Pro Thr Asp Leu Gly Asp Gly Leu Ala Gln Leu Leu Lys
120 125 130
ctg cct gaa agg ttt gtc atc ggt gct gtg gca gga agc cga ctg atg 547
Leu Pro Glu Arg Phe Val Ile Gly Ala Val Ala Gly Ser Arg Leu Met
135 140 145
acg ctt ttt cgg gaa gat tgg tac tcc atg tcc agg gca agg cgt gcc 595
Thr Leu Phe Arg Glu Asp Trp Tyr Ser Met Ser Arg Ala Arg Arg Ala
150 155 160 165
cgc gga att gct gat cag ggc aag atc aag cac ttt ttc acc atg act 643
Arg Gly Ile Ala Asp Gln Gly Lys Ile Lys His Phe Phe Thr Met Thr
170 175 180
ttt ggt ttg ttg gtg ctc tcg ctt cgc cgt gga tcc aag ctt gca acg 691
Phe Gly Leu Leu Val Leu Ser Leu Arg Arg Gly Ser Lys Leu Ala Thr
185 190 195
gcg atg gaa gca cgc ggt ttt ggt cgc acg act ggc cgc acc tgg gca 739
Ala Met Glu Ala Arg Gly Phe Gly Arg Thr Thr Gly Arg Thr Trp Ala
200 205 210
agg gaa tcc acc gtc ggc gcg cgc gat ctg gtg ctc atc ttg gtg tgt 787
Arg Glu Ser Thr Val Gly Ala Arg Asp Leu Val Leu Ile Leu Val Cys
215 220 225
gct gcc att tcc gcg atc gct cta acc gtg tcc att cag act ggt ttc 835
Ala Ala Ile Ser Ala Ile Ala Leu Thr Val Ser Ile Gln Thr Gly Phe
230 235 240 245
ttt aag ttc ttg ggc aca tgatcacagt tttaattgat gga 876
Phe Lys Phe Leu Gly Thr
250
<210> 434
<211> 251
<212> PRT
<213> Corynebacterium glutamicum
<400> 434
Val Asn Leu Leu Ile Lys Ile Asn Pro Val Thr Arg Ile Ile Ala Leu
1 5 10 15
Met Val Leu Thr Thr Pro Leu Leu Leu Ser Leu Asp Val Met Ser Ala
20 25 30
Ala Ile Ala Leu Val Ala Thr Ile Ile Leu Ala Pro Phe Ala Gly Val
35 40 45
Thr Trp Lys Met Leu Leu Lys Arg Gly Trp Met Leu Phe Leu Met Ala
50 55 60
Pro Val Ala Ala Leu Ser Met Ala Leu Tyr Gly Arg Pro Asp Gly Lys
65 70 75 80
Glu Tyr Phe Ser Phe Leu Leu Ile His Val Thr Asp Asn Ser Leu Ala
85 90 95
Leu Ala Ala Ala Ile Gly Leu Arg Val Leu Ala Ile Gly Leu Pro Val
100 105 110
Val Val Leu Ile Ala Arg Ile Asp Pro Thr Asp Leu Gly Asp Gly Leu
115 120 125
Ala Gln Leu Leu Lys Leu Pro Glu Arg Phe Val Ile Gly Ala Val Ala
130 135 140
Gly Ser Arg Leu Met Thr Leu Phe Arg Glu Asp Trp Tyr Ser Met Ser
145 150 155 160
Arg Ala Arg Arg Ala Arg Gly Ile Ala Asp Gln Gly Lys Ile Lys His
165 170 175
Phe Phe Thr Met Thr Phe Gly Leu Leu Val Leu Ser Leu Arg Arg Gly
180 185 190
Ser Lys Leu Ala Thr Ala Met Glu Ala Arg Gly Phe Gly Arg Thr Thr
195 200 205
Gly Arg Thr Trp Ala Arg Glu Ser Thr Val Gly Ala Arg Asp Leu Val
210 215 220
Leu Ile Leu Val Cys Ala Ala Ile Ser Ala Ile Ala Leu Thr Val Ser
225 230 235 240
Ile Gln Thr Gly Phe Phe Lys Phe Leu Gly Thr
245 250
<210> 435
<211> 732
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(709)
<223> RXA00851
<400> 435
ttgagcgggt catttgcatc aatgatcata aaatcgctgc tgatggccct ccgcaaaagt 60
ccattgacct gtacgtatcg cttatggcgg aacctgcgaa atg aac agt att cct 115
Met Asn Ser Ile Pro
1 5
tta ggt ttt tac gtc gat aag caa tct gtt gtt cat tct ttt cct gct 163
Leu Gly Phe Tyr Val Asp Lys Gln Ser Val Val His Ser Phe Pro Ala
10 15 20
ttg tgg aaa ttc cca ctt ctg ctg ttt ttc atc atc ggc ggc tcc atc 211
Leu Trp Lys Phe Pro Leu Leu Leu Phe Phe Ile Ile Gly Gly Ser Ile
25 30 35
gcg gct tct acc ccg gtt cat ggg ttg att ttg gtg ggg att gca gtg 259
Ala Ala Ser Thr Pro Val His Gly Leu Ile Leu Val Gly Ile Ala Val
40 45 50
gtg ttt tac gtg ctg gcg aag att ccg ctg aag gtc gcg tgg gag cag 307
Val Phe Tyr Val Leu Ala Lys Ile Pro Leu Lys Val Ala Trp Glu Gln
55 60 65
ttg tgg cca gtg ctg ccg att ttg atc atg ctc ggt gcg ttt cag tgg 355
Leu Trp Pro Val Leu Pro Ile Leu Ile Met Leu Gly Ala Phe Gln Trp
70 75 80 85
tgg cag cgc ggc ttt gat ttc gcg gca acc aca gtg ctc acg ctg ttt 403
Trp Gln Arg Gly Phe Asp Phe Ala Ala Thr Thr Val Leu Thr Leu Phe
90 95 100
tcc gcg gtg atg gcc gcc atg ttg ttg acg ttg acc acg cgg ttg gaa 451
Ser Ala Val Met Ala Ala Met Leu Leu Thr Leu Thr Thr Arg Leu Glu
105 110 115
gcg ctc atg aat gca gtt gag cgg atg ttg cag cct ttt gca cgt ttt 499
Ala Leu Met Asn Ala Val Glu Arg Met Leu Gln Pro Phe Ala Arg Phe
120 125 130
ggc ctg cca gta gag acg atc acc ttg gct att tct ctc acg att cgg 547
Gly Leu Pro Val Glu Thr Ile Thr Leu Ala Ile Ser Leu Thr Ile Arg
135 140 145
ctc att ccg ctg caa tta gcc acg gtg aag gaa gtc ctc gat gcc cgt 595
Leu Ile Pro Leu Gln Leu Ala Thr Val Lys Glu Val Leu Asp Ala Arg
150 155 160 165
aaa gct cgt ggt gcc ggt ttt tct atc gcc gcg ttt ggc acg cct gtg 643
Lys Ala Arg Gly Ala Gly Phe Ser Ile Ala Ala Phe Gly Thr Pro Val
170 175 180
atc atc aga tca ata aag agg gcc cgc aat atc ggc gat gct ctt ctc 691
Ile Ile Arg Ser Ile Lys Arg Ala Arg Asn Ile Gly Asp Ala Leu Leu
185 190 195
gca cgt ggt gcc ggc gat taatttcttt caacacatag caa 732
Ala Arg Gly Ala Gly Asp
200
<210> 436
<211> 203
<212> PRT
<213> Corynebacterium glutamicum
<400> 436
Met Asn Ser Ile Pro Leu Gly Phe Tyr Val Asp Lys Gln Ser Val Val
1 5 10 15
His Ser Phe Pro Ala Leu Trp Lys Phe Pro Leu Leu Leu Phe Phe Ile
20 25 30
Ile Gly Gly Ser Ile Ala Ala Ser Thr Pro Val His Gly Leu Ile Leu
35 40 45
Val Gly Ile Ala Val Val Phe Tyr Val Leu Ala Lys Ile Pro Leu Lys
50 55 60
Val Ala Trp Glu Gln Leu Trp Pro Val Leu Pro Ile Leu Ile Met Leu
65 70 75 80
Gly Ala Phe Gln Trp Trp Gln Arg Gly Phe Asp Phe Ala Ala Thr Thr
85 90 95
Val Leu Thr Leu Phe Ser Ala Val Met Ala Ala Met Leu Leu Thr Leu
100 105 110
Thr Thr Arg Leu Glu Ala Leu Met Asn Ala Val Glu Arg Met Leu Gln
115 120 125
Pro Phe Ala Arg Phe Gly Leu Pro Val Glu Thr Ile Thr Leu Ala Ile
130 135 140
Ser Leu Thr Ile Arg Leu Ile Pro Leu Gln Leu Ala Thr Val Lys Glu
145 150 155 160
Val Leu Asp Ala Arg Lys Ala Arg Gly Ala Gly Phe Ser Ile Ala Ala
165 170 175
Phe Gly Thr Pro Val Ile Ile Arg Ser Ile Lys Arg Ala Arg Asn Ile
180 185 190
Gly Asp Ala Leu Leu Ala Arg Gly Ala Gly Asp
195 200
<210> 437
<211> 725
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (3)..(695)
<223> RXS03220
<400> 437
cc atg ggc tta agg gaa att ttg tcc agc aag tgg ctt gtg cgc atc 47
Met Gly Leu Arg Glu Ile Leu Ser Ser Lys Trp Leu Val Arg Ile
1 5 10 15
ctc ctg gta ggt atc gga ttg ggt gtc gca cag cag ctg acc ggc atc 95
Leu Leu Val Gly Ile Gly Leu Gly Val Ala Gln Gln Leu Thr Gly Ile
20 25 30
aac tcc atc atg tac tac ggc cag gtt gtt ctc att gag gct ggt ttc 143
Asn Ser Ile Met Tyr Tyr Gly Gln Val Val Leu Ile Glu Ala Gly Phe
35 40 45
tcc gag aat gca gct ctg atc gcc aac gtg gcg cca gga gtg atc gca 191
Ser Glu Asn Ala Ala Leu Ile Ala Asn Val Ala Pro Gly Val Ile Ala
50 55 60
gtt gtc ggt gca ttc atc gca ctg tgg atg atg gat ggt atc aac cgc 239
Val Val Gly Ala Phe Ile Ala Leu Trp Met Met Asp Gly Ile Asn Arg
65 70 75
cgt acc acc ctc att acc ggt tat tct ctc acc acc att agc cac gta 287
Arg Thr Thr Leu Ile Thr Gly Tyr Ser Leu Thr Thr Ile Ser His Val
80 85 90 95
ttg atc ggt atc gca tcc gta gca ttc cca gtc ggc gat cct ctt cgc 335
Leu Ile Gly Ile Ala Ser Val Ala Phe Pro Val Gly Asp Pro Leu Arg
100 105 110
ccc tac gtt atc ttg act ctg gtt gtg gtc ttc gtg gga tcc atg cag 383
Pro Tyr Val Ile Leu Thr Leu Val Val Val Phe Val Gly Ser Met Gln
115 120 125
acc ttc ctc aac gta gct acc tgg gtt atg ctc tct gag ctc ttc ccg 431
Thr Phe Leu Asn Val Ala Thr Trp Val Met Leu Ser Glu Leu Phe Pro
130 135 140
ctg gca atg cgc ggt ttc gca atc ggt atc tca gtg ttc ttc ctc tgg 479
Leu Ala Met Arg Gly Phe Ala Ile Gly Ile Ser Val Phe Phe Leu Trp
145 150 155
atc gca aac gcg ttc ctc gga ttg ttc ttc cca acc atc atg gaa gca 527
Ile Ala Asn Ala Phe Leu Gly Leu Phe Phe Pro Thr Ile Met Glu Ala
160 165 170 175
gta gga cta acc gga acc ttc ttc atg ttc gcc gga atc ggt gtg gtt 575
Val Gly Leu Thr Gly Thr Phe Phe Met Phe Ala Gly Ile Gly Val Val
180 185 190
gcc ttg atc ttc atc tac acc cag gtt cct gaa act cgt gga cgt acc 623
Ala Leu Ile Phe Ile Tyr Thr Gln Val Pro Glu Thr Arg Gly Arg Thr
195 200 205
ttg gag gag att gat gag gat gtt act tcc ggt gtc att ttc aac aag 671
Leu Glu Glu Ile Asp Glu Asp Val Thr Ser Gly Val Ile Phe Asn Lys
210 215 220
gac atc cga aaa gga aag gtg cac taaaaaccca gacactgcat agataacacg 725
Asp Ile Arg Lys Gly Lys Val His
225 230
<210> 438
<211> 231
<212> PRT
<213> Corynebacterium glutamicum
<400> 438
Met Gly Leu Arg Glu Ile Leu Ser Ser Lys Trp Leu Val Arg Ile Leu
1 5 10 15
Leu Val Gly Ile Gly Leu Gly Val Ala Gln Gln Leu Thr Gly Ile Asn
20 25 30
Ser Ile Met Tyr Tyr Gly Gln Val Val Leu Ile Glu Ala Gly Phe Ser
35 40 45
Glu Asn Ala Ala Leu Ile Ala Asn Val Ala Pro Gly Val Ile Ala Val
50 55 60
Val Gly Ala Phe Ile Ala Leu Trp Met Met Asp Gly Ile Asn Arg Arg
65 70 75 80
Thr Thr Leu Ile Thr Gly Tyr Ser Leu Thr Thr Ile Ser His Val Leu
85 90 95
Ile Gly Ile Ala Ser Val Ala Phe Pro Val Gly Asp Pro Leu Arg Pro
100 105 110
Tyr Val Ile Leu Thr Leu Val Val Val Phe Val Gly Ser Met Gln Thr
115 120 125
Phe Leu Asn Val Ala Thr Trp Val Met Leu Ser Glu Leu Phe Pro Leu
130 135 140
Ala Met Arg Gly Phe Ala Ile Gly Ile Ser Val Phe Phe Leu Trp Ile
145 150 155 160
Ala Asn Ala Phe Leu Gly Leu Phe Phe Pro Thr Ile Met Glu Ala Val
165 170 175
Gly Leu Thr Gly Thr Phe Phe Met Phe Ala Gly Ile Gly Val Val Ala
180 185 190
Leu Ile Phe Ile Tyr Thr Gln Val Pro Glu Thr Arg Gly Arg Thr Leu
195 200 205
Glu Glu Ile Asp Glu Asp Val Thr Ser Gly Val Ile Phe Asn Lys Asp
210 215 220
Ile Arg Lys Gly Lys Val His
225 230
<210> 439
<211> 408
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(385)
<223> FRXA02762
<400> 439
ttcccagtcg gcgatcctct tcgcccctac gttatcttga ctctggttgt ggtcttcgtg 60
ggatccatgc agaccttcct caacggtagc tacctgggtt atg ctc tct gag ctc 115
Met Leu Ser Glu Leu
1 5
ttc ccg ctg gca atg cgc ggt ttc gca atc ggt atc tca gtg ttc ttc 163
Phe Pro Leu Ala Met Arg Gly Phe Ala Ile Gly Ile Ser Val Phe Phe
10 15 20
ctc tgg atc gca aac gcg ttc ctc gga ttg ttc ttc cca acc atc atg 211
Leu Trp Ile Ala Asn Ala Phe Leu Gly Leu Phe Phe Pro Thr Ile Met
25 30 35
gaa gca gta gga cta acc gga acc ttc ttc atg ttc gcc gga atc ggt 259
Glu Ala Val Gly Leu Thr Gly Thr Phe Phe Met Phe Ala Gly Ile Gly
40 45 50
gtg gtt gcc ttg atc ttc atc tac acc cag gtt cct gaa act cgt gga 307
Val Val Ala Leu Ile Phe Ile Tyr Thr Gln Val Pro Glu Thr Arg Gly
55 60 65
cgt acc ttg gag gag att gat gag gat gtt act tcc ggt gtc att ttc 355
Arg Thr Leu Glu Glu Ile Asp Glu Asp Val Thr Ser Gly Val Ile Phe
70 75 80 85
aac aag gac atc cga aaa gga aag gtg cac taaaaaccca gacactgcat 405
Asn Lys Asp Ile Arg Lys Gly Lys Val His
90 95
aga 408
<210> 440
<211> 95
<212> PRT
<213> Corynebacterium glutamicum
<400> 440
Met Leu Ser Glu Leu Phe Pro Leu Ala Met Arg Gly Phe Ala Ile Gly
1 5 10 15
Ile Ser Val Phe Phe Leu Trp Ile Ala Asn Ala Phe Leu Gly Leu Phe
20 25 30
Phe Pro Thr Ile Met Glu Ala Val Gly Leu Thr Gly Thr Phe Phe Met
35 40 45
Phe Ala Gly Ile Gly Val Val Ala Leu Ile Phe Ile Tyr Thr Gln Val
50 55 60
Pro Glu Thr Arg Gly Arg Thr Leu Glu Glu Ile Asp Glu Asp Val Thr
65 70 75 80
Ser Gly Val Ile Phe Asn Lys Asp Ile Arg Lys Gly Lys Val His
85 90 95
<210> 441
<211> 789
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(766)
<223> RXN00092
<400> 441
cgaaaccaga aacacccagc ggctcctcgt cgaaaagcga atctttgaac tagaagccca 60
ggcacgttgg ctcgaccgaa ttgaagcatt ggagcagtaa atg aca aac acg cct 115
Met Thr Asn Thr Pro
1 5
ttc ccc ctt gaa ctt caa aac atc tcc tgc gcc ttc gga gaa ggc cca 163
Phe Pro Leu Glu Leu Gln Asn Ile Ser Cys Ala Phe Gly Glu Gly Pro
10 15 20
cgc cac gtc tcc gcg ctc aac aac gtc tcg ctg gca gtc aat ccc ggc 211
Arg His Val Ser Ala Leu Asn Asn Val Ser Leu Ala Val Asn Pro Gly
25 30 35
gaa ctc gtt gcc atc atg ggc ccg tcc ggc tca gga aaa tcc acc ttg 259
Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu
40 45 50
ctc aac gtc gcc ggc ctc ctg cag cgc gca acc tct ggc cat gtg ctt 307
Leu Asn Val Ala Gly Leu Leu Gln Arg Ala Thr Ser Gly His Val Leu
55 60 65
atc gac ggt gcc agc gcc tca gac ctc aac gcc aaa cgc gca gct gaa 355
Ile Asp Gly Ala Ser Ala Ser Asp Leu Asn Ala Lys Arg Ala Ala Glu
70 75 80 85
acc agg cgt cgc cac atc gga gtt att ttc caa aac tac aac ctg gtc 403
Thr Arg Arg Arg His Ile Gly Val Ile Phe Gln Asn Tyr Asn Leu Val
90 95 100
ccc acc ctc acc gtc gga gaa aac gtc ggt ctg ccc cta gaa ctc gac 451
Pro Thr Leu Thr Val Gly Glu Asn Val Gly Leu Pro Leu Glu Leu Asp
105 110 115
ggc aaa acc gac cgc cag gca gta gca atc gca ctc gcg gaa gtc ggc 499
Gly Lys Thr Asp Arg Gln Ala Val Ala Ile Ala Leu Ala Glu Val Gly
120 125 130
ctc gaa ggc ttc gac gac cgc ttc ccc gaa gag atc tcc ggc ggc caa 547
Leu Glu Gly Phe Asp Asp Arg Phe Pro Glu Glu Ile Ser Gly Gly Gln
135 140 145
gcc cag cgc gtc gcc atc gcg aga gcc ctc atc ggc ccc cga aaa atc 595
Ala Gln Arg Val Ala Ile Ala Arg Ala Leu Ile Gly Pro Arg Lys Ile
150 155 160 165
ttg ctt gcc gac gaa ccc acc ggc gcc ctc gac acc tcc acc ggc gac 643
Leu Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp Thr Ser Thr Gly Asp
170 175 180
gca gtc ctc cgc gtc ctc cgc caa aga atc gat tcc ggt gcc gca ggc 691
Ala Val Leu Arg Val Leu Arg Gln Arg Ile Asp Ser Gly Ala Ala Gly
185 190 195
ctc ctt gtc acc cac gaa ccc cgc ttc gcc gcg tgg gca gac cga aca 739
Leu Leu Val Thr His Glu Pro Arg Phe Ala Ala Trp Ala Asp Arg Thr
200 205 210
atc atg ctt agg gat ggt gaa atc cag tgaccacact tctagcagca 786
Ile Met Leu Arg Asp Gly Glu Ile Gln
215 220
acc 789
<210> 442
<211> 222
<212> PRT
<213> Corynebacterium glutamicum
<400> 442
Met Thr Asn Thr Pro Phe Pro Leu Glu Leu Gln Asn Ile Ser Cys Ala
1 5 10 15
Phe Gly Glu Gly Pro Arg His Val Ser Ala Leu Asn Asn Val Ser Leu
20 25 30
Ala Val Asn Pro Gly Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ser
35 40 45
Gly Lys Ser Thr Leu Leu Asn Val Ala Gly Leu Leu Gln Arg Ala Thr
50 55 60
Ser Gly His Val Leu Ile Asp Gly Ala Ser Ala Ser Asp Leu Asn Ala
65 70 75 80
Lys Arg Ala Ala Glu Thr Arg Arg Arg His Ile Gly Val Ile Phe Gln
85 90 95
Asn Tyr Asn Leu Val Pro Thr Leu Thr Val Gly Glu Asn Val Gly Leu
100 105 110
Pro Leu Glu Leu Asp Gly Lys Thr Asp Arg Gln Ala Val Ala Ile Ala
115 120 125
Leu Ala Glu Val Gly Leu Glu Gly Phe Asp Asp Arg Phe Pro Glu Glu
130 135 140
Ile Ser Gly Gly Gln Ala Gln Arg Val Ala Ile Ala Arg Ala Leu Ile
145 150 155 160
Gly Pro Arg Lys Ile Leu Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp
165 170 175
Thr Ser Thr Gly Asp Ala Val Leu Arg Val Leu Arg Gln Arg Ile Asp
180 185 190
Ser Gly Ala Ala Gly Leu Leu Val Thr His Glu Pro Arg Phe Ala Ala
195 200 205
Trp Ala Asp Arg Thr Ile Met Leu Arg Asp Gly Glu Ile Gln
210 215 220
<210> 443
<211> 227
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(204)
<223> FRXA00092
<400> 443
atc gcg aga gcc ctc atc ggc ccc cga aaa atc ttg ctt gcc gac gaa 48
Ile Ala Arg Ala Leu Ile Gly Pro Arg Lys Ile Leu Leu Ala Asp Glu
1 5 10 15
ccc acc ggc gcc ctc gac acc tcc acc ggc gac gca gtc ctc cgc gtc 96
Pro Thr Gly Ala Leu Asp Thr Ser Thr Gly Asp Ala Val Leu Arg Val
20 25 30
ctc cgc caa aga atc gat tcc ggt gcc gca ggc ctc ctt gtc acc cac 144
Leu Arg Gln Arg Ile Asp Ser Gly Ala Ala Gly Leu Leu Val Thr His
35 40 45
gaa ccc cgc ttc gcc gcg tgg gca gac cga aca atc atg ctt agg gat 192
Glu Pro Arg Phe Ala Ala Trp Ala Asp Arg Thr Ile Met Leu Arg Asp
50 55 60
ggt gaa atc cag tgaccacact tctagcagca acc 227
Gly Glu Ile Gln
65
<210> 444
<211> 68
<212> PRT
<213> Corynebacterium glutamicum
<400> 444
Ile Ala Arg Ala Leu Ile Gly Pro Arg Lys Ile Leu Leu Ala Asp Glu
1 5 10 15
Pro Thr Gly Ala Leu Asp Thr Ser Thr Gly Asp Ala Val Leu Arg Val
20 25 30
Leu Arg Gln Arg Ile Asp Ser Gly Ala Ala Gly Leu Leu Val Thr His
35 40 45
Glu Pro Arg Phe Ala Ala Trp Ala Asp Arg Thr Ile Met Leu Arg Asp
50 55 60
Gly Glu Ile Gln
65
<210> 445
<211> 975
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(952)
<223> RXN03060
<400> 445
tatgtccttt ggctccggta ccctggcagg agtacctggg ctgtttttct aaaatggcct 60
gacgttttca agattgaatt taaggaaagc atcgtagttc atg agt aac cct gcc 115
Met Ser Asn Pro Ala
1 5
gcg agc aca cct gcc aac aat tcg gac gat gtt gcg aag gag aat tgg 163
Ala Ser Thr Pro Ala Asn Asn Ser Asp Asp Val Ala Lys Glu Asn Trp
10 15 20
gac tct tct ttt acg ccg aag act gac att gac tct tcc cag cct gtc 211
Asp Ser Ser Phe Thr Pro Lys Thr Asp Ile Asp Ser Ser Gln Pro Val
25 30 35
aat aac tcg act ggt gaa gcc gct gcg cgc gca gtg aac ctg tac aag 259
Asn Asn Ser Thr Gly Glu Ala Ala Ala Arg Ala Val Asn Leu Tyr Lys
40 45 50
gcg tat ggc cag ggt gat acc act gtc acc gcg ttg gat cac gtc aac 307
Ala Tyr Gly Gln Gly Asp Thr Thr Val Thr Ala Leu Asp His Val Asn
55 60 65
gtg gag ttt gag aag aac aag ttc act gcc atc atg ggt cct tct ggc 355
Val Glu Phe Glu Lys Asn Lys Phe Thr Ala Ile Met Gly Pro Ser Gly
70 75 80 85
tcg ggt aag tcc acg ttg atg cac tgc atg gct ggt ctg gat gct gcg 403
Ser Gly Lys Ser Thr Leu Met His Cys Met Ala Gly Leu Asp Ala Ala
90 95 100
act ggt ggt tcg gca ttc att ggt gat acg gat ctg tcg cgg ttg aag 451
Thr Gly Gly Ser Ala Phe Ile Gly Asp Thr Asp Leu Ser Arg Leu Lys
105 110 115
gac aaa gag atg acc tct ttg cgt cgt gat cgt ttg gga ttc att ttc 499
Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg Leu Gly Phe Ile Phe
120 125 130
cag tcg ttc aac ttg gtt cct act ctg acg gcg tcg gag aac att acg 547
Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Ala Ser Glu Asn Ile Thr
135 140 145
ctg cct acc gat atc gcg ggc cgc aag att gat cag tcg tgg ttc gat 595
Leu Pro Thr Asp Ile Ala Gly Arg Lys Ile Asp Gln Ser Trp Phe Asp
150 155 160 165
gag att acc tct cgt ctg ggt ctg act gag cgc ctt aag cac cgt cct 643
Glu Ile Thr Ser Arg Leu Gly Leu Thr Glu Arg Leu Lys His Arg Pro
170 175 180
gca gag ctc tct ggt ggt cag cag cag cgt gtg gcg tgt gct cgt gcg 691
Ala Glu Leu Ser Gly Gly Gln Gln Gln Arg Val Ala Cys Ala Arg Ala
185 190 195
ttg gtg tct cgt ccg gag atc att ttc ggc gac gag cca acc ggt aac 739
Leu Val Ser Arg Pro Glu Ile Ile Phe Gly Asp Glu Pro Thr Gly Asn
200 205 210
ttg gat tcg aac tct tct agg gaa gtg ctg gat atc ctg cgc acc gca 787
Leu Asp Ser Asn Ser Ser Arg Glu Val Leu Asp Ile Leu Arg Thr Ala
215 220 225
gtt gat cag gat gat cag acc gtt gtg atc gtt acc cac gat gcc aag 835
Val Asp Gln Asp Asp Gln Thr Val Val Ile Val Thr His Asp Ala Lys
230 235 240 245
gcg gcg tcc tat gca gat cgt gtc att ttc ttg gcg gac ggt cgt atc 883
Ala Ala Ser Tyr Ala Asp Arg Val Ile Phe Leu Ala Asp Gly Arg Ile
250 255 260
gtg aac cag ttg ttt gat ccc acc atc gag gaa atc ttg gcc acg atg 931
Val Asn Gln Leu Phe Asp Pro Thr Ile Glu Glu Ile Leu Ala Thr Met
265 270 275
aac gga att gag gat att gcc taatgaattc cggttccaca atg 975
Asn Gly Ile Glu Asp Ile Ala
280
<210> 446
<211> 284
<212> PRT
<213> Corynebacterium glutamicum
<400> 446
Met Ser Asn Pro Ala Ala Ser Thr Pro Ala Asn Asn Ser Asp Asp Val
1 5 10 15
Ala Lys Glu Asn Trp Asp Ser Ser Phe Thr Pro Lys Thr Asp Ile Asp
20 25 30
Ser Ser Gln Pro Val Asn Asn Ser Thr Gly Glu Ala Ala Ala Arg Ala
35 40 45
Val Asn Leu Tyr Lys Ala Tyr Gly Gln Gly Asp Thr Thr Val Thr Ala
50 55 60
Leu Asp His Val Asn Val Glu Phe Glu Lys Asn Lys Phe Thr Ala Ile
65 70 75 80
Met Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu Met His Cys Met Ala
85 90 95
Gly Leu Asp Ala Ala Thr Gly Gly Ser Ala Phe Ile Gly Asp Thr Asp
100 105 110
Leu Ser Arg Leu Lys Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg
115 120 125
Leu Gly Phe Ile Phe Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Ala
130 135 140
Ser Glu Asn Ile Thr Leu Pro Thr Asp Ile Ala Gly Arg Lys Ile Asp
145 150 155 160
Gln Ser Trp Phe Asp Glu Ile Thr Ser Arg Leu Gly Leu Thr Glu Arg
165 170 175
Leu Lys His Arg Pro Ala Glu Leu Ser Gly Gly Gln Gln Gln Arg Val
180 185 190
Ala Cys Ala Arg Ala Leu Val Ser Arg Pro Glu Ile Ile Phe Gly Asp
195 200 205
Glu Pro Thr Gly Asn Leu Asp Ser Asn Ser Ser Arg Glu Val Leu Asp
210 215 220
Ile Leu Arg Thr Ala Val Asp Gln Asp Asp Gln Thr Val Val Ile Val
225 230 235 240
Thr His Asp Ala Lys Ala Ala Ser Tyr Ala Asp Arg Val Ile Phe Leu
245 250 255
Ala Asp Gly Arg Ile Val Asn Gln Leu Phe Asp Pro Thr Ile Glu Glu
260 265 270
Ile Leu Ala Thr Met Asn Gly Ile Glu Asp Ile Ala
275 280
<210> 447
<211> 538
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(538)
<223> FRXA02618
<400> 447
cgaaaccaga aacacccagc ggctcctcgt cgaaaagcga atctttgaac tagaagccca 60
ggcacgttgg ctcgaccgaa ttgaagcatt ggagcagtaa atg aca aac acg cct 115
Met Thr Asn Thr Pro
1 5
ttc ccc ctt gaa ctt caa aac atc tcc tgc gcc ttc gga gaa ggc cca 163
Phe Pro Leu Glu Leu Gln Asn Ile Ser Cys Ala Phe Gly Glu Gly Pro
10 15 20
cgc cac gtc tcc gcg ctc aac aac gtc tcg ctg gca gtc aat ccc ggc 211
Arg His Val Ser Ala Leu Asn Asn Val Ser Leu Ala Val Asn Pro Gly
25 30 35
gaa ctc gtt gcc atc atg ggc ccg tcc ggc tca gga aaa tcc acc ttg 259
Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu
40 45 50
ctc aac gtc gcc ggc ctc ctg cag cgc gca acc tct ggc cat gtg ctt 307
Leu Asn Val Ala Gly Leu Leu Gln Arg Ala Thr Ser Gly His Val Leu
55 60 65
atc gac ggt gcc agc gcc tca gac ctc aac gcc aaa cgc gca gct gaa 355
Ile Asp Gly Ala Ser Ala Ser Asp Leu Asn Ala Lys Arg Ala Ala Glu
70 75 80 85
acc agg cgt cgc cac atc gga gtt att ttc caa aac tac aac ctg gtc 403
Thr Arg Arg Arg His Ile Gly Val Ile Phe Gln Asn Tyr Asn Leu Val
90 95 100
ccc acc ctc acc gtc gga gaa aac atc ggt ctg ccc cta gaa ctc gac 451
Pro Thr Leu Thr Val Gly Glu Asn Ile Gly Leu Pro Leu Glu Leu Asp
105 110 115
ggc aaa acc gac cgc cag gca gta gca atc gca ctc gcg gaa gtc ggc 499
Gly Lys Thr Asp Arg Gln Ala Val Ala Ile Ala Leu Ala Glu Val Gly
120 125 130
ctc aag ggc tct acg acc gct ttt ccc gag aga tct ctg 538
Leu Lys Gly Ser Thr Thr Ala Phe Pro Glu Arg Ser Leu
135 140 145
<210> 448
<211> 146
<212> PRT
<213> Corynebacterium glutamicum
<400> 448
Met Thr Asn Thr Pro Phe Pro Leu Glu Leu Gln Asn Ile Ser Cys Ala
1 5 10 15
Phe Gly Glu Gly Pro Arg His Val Ser Ala Leu Asn Asn Val Ser Leu
20 25 30
Ala Val Asn Pro Gly Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ser
35 40 45
Gly Lys Ser Thr Leu Leu Asn Val Ala Gly Leu Leu Gln Arg Ala Thr
50 55 60
Ser Gly His Val Leu Ile Asp Gly Ala Ser Ala Ser Asp Leu Asn Ala
65 70 75 80
Lys Arg Ala Ala Glu Thr Arg Arg Arg His Ile Gly Val Ile Phe Gln
85 90 95
Asn Tyr Asn Leu Val Pro Thr Leu Thr Val Gly Glu Asn Ile Gly Leu
100 105 110
Pro Leu Glu Leu Asp Gly Lys Thr Asp Arg Gln Ala Val Ala Ile Ala
115 120 125
Leu Ala Glu Val Gly Leu Lys Gly Ser Thr Thr Ala Phe Pro Glu Arg
130 135 140
Ser Leu
145
<210> 449
<211> 975
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(952)
<223> FRXA02900
<400> 449
tatgtccttt ggctccggta ccctggcagg agtacctggg ctgtttttct aaaatggcct 60
gacgttttca agattgaatt taaggaaagc atcgtagttc atg agt aac cct gcc 115
Met Ser Asn Pro Ala
1 5
gcg agc aca cct gcc aac aat tcg gac gat gtt gcg aag gag aat tgg 163
Ala Ser Thr Pro Ala Asn Asn Ser Asp Asp Val Ala Lys Glu Asn Trp
10 15 20
gac tct tct ttt acg ccg aag act gac att gac tct tcc cag cct gtc 211
Asp Ser Ser Phe Thr Pro Lys Thr Asp Ile Asp Ser Ser Gln Pro Val
25 30 35
aat aac tcg act ggt gaa gcc gct gcg cgc gca gtg aac ctg tac aag 259
Asn Asn Ser Thr Gly Glu Ala Ala Ala Arg Ala Val Asn Leu Tyr Lys
40 45 50
gcg tat ggc cag ggt gat acc act gtc acc gcg ttg gat cac gtc aac 307
Ala Tyr Gly Gln Gly Asp Thr Thr Val Thr Ala Leu Asp His Val Asn
55 60 65
gtg gag ttt gag aag aac aag ttc act gcc atc atg ggt cct tct ggc 355
Val Glu Phe Glu Lys Asn Lys Phe Thr Ala Ile Met Gly Pro Ser Gly
70 75 80 85
tcg ggt aag tcc acg ttg atg cac tgc atg gct ggt ctg gat gct gcg 403
Ser Gly Lys Ser Thr Leu Met His Cys Met Ala Gly Leu Asp Ala Ala
90 95 100
act ggt ggt tcg gca ttc att ggt gat acg gat ctg tcg cgg ttg aag 451
Thr Gly Gly Ser Ala Phe Ile Gly Asp Thr Asp Leu Ser Arg Leu Lys
105 110 115
gac aaa gag atg acc tct ttg cgt cgt gat cgt ttg gga ttc att ttc 499
Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg Leu Gly Phe Ile Phe
120 125 130
cag tcg ttc aac ttg gtt cct act ctg acg gcg tcg gag aac att acg 547
Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Ala Ser Glu Asn Ile Thr
135 140 145
ctg cct acc gat atc gcg ggc cgc aag att gat cag tcg tgg ttc gat 595
Leu Pro Thr Asp Ile Ala Gly Arg Lys Ile Asp Gln Ser Trp Phe Asp
150 155 160 165
gag att acc tct cgt ctg ggt ctg act gag cgc ctt aag cac cgt cct 643
Glu Ile Thr Ser Arg Leu Gly Leu Thr Glu Arg Leu Lys His Arg Pro
170 175 180
gca gag ctc tct ggt ggt cag cag cag cgt gtg gcg tgt gct cgt gcg 691
Ala Glu Leu Ser Gly Gly Gln Gln Gln Arg Val Ala Cys Ala Arg Ala
185 190 195
ttg gtg tct cgt ccg gag atc att ttc ggc gac gag cca acc ggt aac 739
Leu Val Ser Arg Pro Glu Ile Ile Phe Gly Asp Glu Pro Thr Gly Asn
200 205 210
ttg gat tcg aac tct tct agg gaa gtg ctg gat atc ctg cgc acc gca 787
Leu Asp Ser Asn Ser Ser Arg Glu Val Leu Asp Ile Leu Arg Thr Ala
215 220 225
gtt gat cag gat gat cag acc gtt gtg atc gtt acc cac gat gcc aag 835
Val Asp Gln Asp Asp Gln Thr Val Val Ile Val Thr His Asp Ala Lys
230 235 240 245
gcg gcg tcc tat gca gat cgt gtc att ttc ttg gcg gac ggt cgt atc 883
Ala Ala Ser Tyr Ala Asp Arg Val Ile Phe Leu Ala Asp Gly Arg Ile
250 255 260
gtg aac cag ttg ttt gat ccc acc atc gag gaa atc ttg gcc acg atg 931
Val Asn Gln Leu Phe Asp Pro Thr Ile Glu Glu Ile Leu Ala Thr Met
265 270 275
aac gga att gag gat att gcc taatgaattc cggttccaca atg 975
Asn Gly Ile Glu Asp Ile Ala
280
<210> 450
<211> 284
<212> PRT
<213> Corynebacterium glutamicum
<400> 450
Met Ser Asn Pro Ala Ala Ser Thr Pro Ala Asn Asn Ser Asp Asp Val
1 5 10 15
Ala Lys Glu Asn Trp Asp Ser Ser Phe Thr Pro Lys Thr Asp Ile Asp
20 25 30
Ser Ser Gln Pro Val Asn Asn Ser Thr Gly Glu Ala Ala Ala Arg Ala
35 40 45
Val Asn Leu Tyr Lys Ala Tyr Gly Gln Gly Asp Thr Thr Val Thr Ala
50 55 60
Leu Asp His Val Asn Val Glu Phe Glu Lys Asn Lys Phe Thr Ala Ile
65 70 75 80
Met Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu Met His Cys Met Ala
85 90 95
Gly Leu Asp Ala Ala Thr Gly Gly Ser Ala Phe Ile Gly Asp Thr Asp
100 105 110
Leu Ser Arg Leu Lys Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg
115 120 125
Leu Gly Phe Ile Phe Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Ala
130 135 140
Ser Glu Asn Ile Thr Leu Pro Thr Asp Ile Ala Gly Arg Lys Ile Asp
145 150 155 160
Gln Ser Trp Phe Asp Glu Ile Thr Ser Arg Leu Gly Leu Thr Glu Arg
165 170 175
Leu Lys His Arg Pro Ala Glu Leu Ser Gly Gly Gln Gln Gln Arg Val
180 185 190
Ala Cys Ala Arg Ala Leu Val Ser Arg Pro Glu Ile Ile Phe Gly Asp
195 200 205
Glu Pro Thr Gly Asn Leu Asp Ser Asn Ser Ser Arg Glu Val Leu Asp
210 215 220
Ile Leu Arg Thr Ala Val Asp Gln Asp Asp Gln Thr Val Val Ile Val
225 230 235 240
Thr His Asp Ala Lys Ala Ala Ser Tyr Ala Asp Arg Val Ile Phe Leu
245 250 255
Ala Asp Gly Arg Ile Val Asn Gln Leu Phe Asp Pro Thr Ile Glu Glu
260 265 270
Ile Leu Ala Thr Met Asn Gly Ile Glu Asp Ile Ala
275 280
<210> 451
<211> 1452
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(1452)
<223> RXS03212
<400> 451
gcc tca ctt aac tgg tca gtc atc gtt cca gcc cta gtc att gtc cta 48
Ala Ser Leu Asn Trp Ser Val Ile Val Pro Ala Leu Val Ile Val Leu
1 5 10 15
gcg aca gtg gtg tgg ggt atc gga ttc aaa gat agc ttt acc aac ttt 96
Ala Thr Val Val Trp Gly Ile Gly Phe Lys Asp Ser Phe Thr Asn Phe
20 25 30
gct agt tct gcg ttg tca gca gta gtt gac aat ctc ggc tgg gcc ttc 144
Ala Ser Ser Ala Leu Ser Ala Val Val Asp Asn Leu Gly Trp Ala Phe
35 40 45
att ttg ttt ggc aca gtc ttt gta ttt ttt atc gtt gtt atc gcc gct 192
Ile Leu Phe Gly Thr Val Phe Val Phe Phe Ile Val Val Ile Ala Ala
50 55 60
agt aaa ttc ggc acg att cgc tta ggc cgc att gat gaa gca cca gag 240
Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile Asp Glu Ala Pro Glu
65 70 75 80
ttt cgc acg gtg tca tgg att tcc atg atg ttt gct gca ggt atg ggt 288
Phe Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly Met Gly
85 90 95
att ggt ttg atg ttc tac gga acc aca gaa cct tta acc ttc tac cgc 336
Ile Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg
100 105 110
aat ggt gta cct gga cat gat gaa cac aat gtt ggc gtt gct atg tcc 384
Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser
115 120 125
acg aca atg ttc cac tgg acc ttg cat cca tgg gct atc tac gca att 432
Thr Thr Met Phe His Trp Thr Leu His Pro Trp Ala Ile Tyr Ala Ile
130 135 140
gtg ggc cta gcc att gcc tat tcg acc ttc cga gtg ggc cgt aaa cag 480
Val Gly Leu Ala Ile Ala Tyr Ser Thr Phe Arg Val Gly Arg Lys Gln
145 150 155 160
ctt cta agc tct gca ttc gtg cca ctc att ggt gaa aaa ggt gca gaa 528
Leu Leu Ser Ser Ala Phe Val Pro Leu Ile Gly Glu Lys Gly Ala Glu
165 170 175
gga tgg ttg ggc aag ctc atc gac atc ctg gcg att atc gcc acc gta 576
Gly Trp Leu Gly Lys Leu Ile Asp Ile Leu Ala Ile Ile Ala Thr Val
180 185 190
ttc ggc acg gca tgt tcc ctt ggc ctt ggt gcc ctg cag att ggt gca 624
Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gln Ile Gly Ala
195 200 205
ggc ctg tcc gca gca aac atc att gaa gat cca agc gat tgg acc atc 672
Gly Leu Ser Ala Ala Asn Ile Ile Glu Asp Pro Ser Asp Trp Thr Ile
210 215 220
gtt ggc att gtt tct gtt ttg acc ctg gca ttt atc ttc tcc gct att 720
Val Gly Ile Val Ser Val Leu Thr Leu Ala Phe Ile Phe Ser Ala Ile
225 230 235 240
tct ggt gtg ggc aag gga atc cag tac ctc tcc aac gcc aac atg gtt 768
Ser Gly Val Gly Lys Gly Ile Gln Tyr Leu Ser Asn Ala Asn Met Val
245 250 255
ctg gca gct ctg ctc gcg att ttc gtg ttc gtt gtc gga cca acc gtg 816
Leu Ala Ala Leu Leu Ala Ile Phe Val Phe Val Val Gly Pro Thr Val
260 265 270
tcg att ttg aac ctg ctg cca ggt tct att ggc aac tac ctg tcc aac 864
Ser Ile Leu Asn Leu Leu Pro Gly Ser Ile Gly Asn Tyr Leu Ser Asn
275 280 285
ttc ttt caa atg gca ggc cgc act gcc atg agt gcc gac ggc aca gca 912
Phe Phe Gln Met Ala Gly Arg Thr Ala Met Ser Ala Asp Gly Thr Ala
290 295 300
ggt gag tgg cta ggt agc tgg acc atc ttc tac tgg gca tgg tgg atc 960
Gly Glu Trp Leu Gly Ser Trp Thr Ile Phe Tyr Trp Ala Trp Trp Ile
305 310 315 320
tct tgg tca cca ttc gta gga atg ttc ttg gca cgt att tcc cgt ggc 1008
Ser Trp Ser Pro Phe Val Gly Met Phe Leu Ala Arg Ile Ser Arg Gly
325 330 335
cgc tcc atc cgt gag ttc atc ctg ggc gtg ttg ctc gtc cca gca ggt 1056
Arg Ser Ile Arg Glu Phe Ile Leu Gly Val Leu Leu Val Pro Ala Gly
340 345 350
gtg tcc acc gta tgg ttc tcc att ttt ggt ggc act gcg att gtc ttc 1104
Val Ser Thr Val Trp Phe Ser Ile Phe Gly Gly Thr Ala Ile Val Phe
355 360 365
gaa caa aat ggg gaa tcc att tgg ggt gat ggt gca gca gaa gag cag 1152
Glu Gln Asn Gly Glu Ser Ile Trp Gly Asp Gly Ala Ala Glu Glu Gln
370 375 380
ctt ttt gga ttg ctt cat gca ctt cca ggt ggg caa atc atg ggc atc 1200
Leu Phe Gly Leu Leu His Ala Leu Pro Gly Gly Gln Ile Met Gly Ile
385 390 395 400
atc gcc atg att ttg ctg ggt act ttc ttc att acc tct gct gac tct 1248
Ile Ala Met Ile Leu Leu Gly Thr Phe Phe Ile Thr Ser Ala Asp Ser
405 410 415
gct tcc acc gtc atg ggc acc atg agt cag cac ggc cag ctg gaa gcc 1296
Ala Ser Thr Val Met Gly Thr Met Ser Gln His Gly Gln Leu Glu Ala
420 425 430
aac aag tgg gtg aca gct gcc tgg ggt gtt gct acc gca gct att gga 1344
Asn Lys Trp Val Thr Ala Ala Trp Gly Val Ala Thr Ala Ala Ile Gly
435 440 445
cta acg cta ttg ctt tct ggt ggt gac aat gcc ttg agc aac ttg caa 1392
Leu Thr Leu Leu Leu Ser Gly Gly Asp Asn Ala Leu Ser Asn Leu Gln
450 455 460
aac gtc acc atc gtg gct gca aca cca ttc ttg ttt gtg gtt att gga 1440
Asn Val Thr Ile Val Ala Ala Thr Pro Phe Leu Phe Val Val Ile Gly
465 470 475 480
ttg atg ttt gcg 1452
Leu Met Phe Ala
<210> 452
<211> 484
<212> PRT
<213> Corynebacterium glutamicum
<400> 452
Ala Ser Leu Asn Trp Ser Val Ile Val Pro Ala Leu Val Ile Val Leu
1 5 10 15
Ala Thr Val Val Trp Gly Ile Gly Phe Lys Asp Ser Phe Thr Asn Phe
20 25 30
Ala Ser Ser Ala Leu Ser Ala Val Val Asp Asn Leu Gly Trp Ala Phe
35 40 45
Ile Leu Phe Gly Thr Val Phe Val Phe Phe Ile Val Val Ile Ala Ala
50 55 60
Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile Asp Glu Ala Pro Glu
65 70 75 80
Phe Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly Met Gly
85 90 95
Ile Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg
100 105 110
Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser
115 120 125
Thr Thr Met Phe His Trp Thr Leu His Pro Trp Ala Ile Tyr Ala Ile
130 135 140
Val Gly Leu Ala Ile Ala Tyr Ser Thr Phe Arg Val Gly Arg Lys Gln
145 150 155 160
Leu Leu Ser Ser Ala Phe Val Pro Leu Ile Gly Glu Lys Gly Ala Glu
165 170 175
Gly Trp Leu Gly Lys Leu Ile Asp Ile Leu Ala Ile Ile Ala Thr Val
180 185 190
Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gln Ile Gly Ala
195 200 205
Gly Leu Ser Ala Ala Asn Ile Ile Glu Asp Pro Ser Asp Trp Thr Ile
210 215 220
Val Gly Ile Val Ser Val Leu Thr Leu Ala Phe Ile Phe Ser Ala Ile
225 230 235 240
Ser Gly Val Gly Lys Gly Ile Gln Tyr Leu Ser Asn Ala Asn Met Val
245 250 255
Leu Ala Ala Leu Leu Ala Ile Phe Val Phe Val Val Gly Pro Thr Val
260 265 270
Ser Ile Leu Asn Leu Leu Pro Gly Ser Ile Gly Asn Tyr Leu Ser Asn
275 280 285
Phe Phe Gln Met Ala Gly Arg Thr Ala Met Ser Ala Asp Gly Thr Ala
290 295 300
Gly Glu Trp Leu Gly Ser Trp Thr Ile Phe Tyr Trp Ala Trp Trp Ile
305 310 315 320
Ser Trp Ser Pro Phe Val Gly Met Phe Leu Ala Arg Ile Ser Arg Gly
325 330 335
Arg Ser Ile Arg Glu Phe Ile Leu Gly Val Leu Leu Val Pro Ala Gly
340 345 350
Val Ser Thr Val Trp Phe Ser Ile Phe Gly Gly Thr Ala Ile Val Phe
355 360 365
Glu Gln Asn Gly Glu Ser Ile Trp Gly Asp Gly Ala Ala Glu Glu Gln
370 375 380
Leu Phe Gly Leu Leu His Ala Leu Pro Gly Gly Gln Ile Met Gly Ile
385 390 395 400
Ile Ala Met Ile Leu Leu Gly Thr Phe Phe Ile Thr Ser Ala Asp Ser
405 410 415
Ala Ser Thr Val Met Gly Thr Met Ser Gln His Gly Gln Leu Glu Ala
420 425 430
Asn Lys Trp Val Thr Ala Ala Trp Gly Val Ala Thr Ala Ala Ile Gly
435 440 445
Leu Thr Leu Leu Leu Ser Gly Gly Asp Asn Ala Leu Ser Asn Leu Gln
450 455 460
Asn Val Thr Ile Val Ala Ala Thr Pro Phe Leu Phe Val Val Ile Gly
465 470 475 480
Leu Met Phe Ala
<210> 453
<211> 945
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(945)
<223> FRXA01591
<400> 453
gcc tca ctt aac tgg tca gtc atc gtt cca gcc cta gtc att gtc cta 48
Ala Ser Leu Asn Trp Ser Val Ile Val Pro Ala Leu Val Ile Val Leu
1 5 10 15
gcg aca gtg gtg tgg ggt atc gga ttc aaa gat agc ttt acc acc ttt 96
Ala Thr Val Val Trp Gly Ile Gly Phe Lys Asp Ser Phe Thr Thr Phe
20 25 30
gct agt tct gcg ttg tca gca gta gtt gac aat ctc ggc tgg gcc ttc 144
Ala Ser Ser Ala Leu Ser Ala Val Val Asp Asn Leu Gly Trp Ala Phe
35 40 45
att ttg ttt ggc aca gtc ttt gta ttt ttt atc gtt gtt atc gcc gct 192
Ile Leu Phe Gly Thr Val Phe Val Phe Phe Ile Val Val Ile Ala Ala
50 55 60
agt aaa ttc ggc acg att cgc tta ggc cgc att gat gaa gca cca gag 240
Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile Asp Glu Ala Pro Glu
65 70 75 80
ttt cgc acg gtg tca tgg att tcc atg atg ttt gct gca ggt atg ggt 288
Phe Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly Met Gly
85 90 95
att ggt ttg atg ttc tac gga acc aca gaa cct tta acc ttc tac cgc 336
Ile Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg
100 105 110
aat ggt gta cct gga cat gat gaa cac aat gtt ggc gtt gct atg tcc 384
Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser
115 120 125
acg aca atg ttc cac tgg acc ttg cat cca tgg gct atc tac gca att 432
Thr Thr Met Phe His Trp Thr Leu His Pro Trp Ala Ile Tyr Ala Ile
130 135 140
gtg ggc cta gcc att gcc tat tcg acc ttc cga gtg ggc cgt aaa cag 480
Val Gly Leu Ala Ile Ala Tyr Ser Thr Phe Arg Val Gly Arg Lys Gln
145 150 155 160
ctt cta agc tct gca ttc gtg cca ctc att ggt gaa aaa ggt gca gaa 528
Leu Leu Ser Ser Ala Phe Val Pro Leu Ile Gly Glu Lys Gly Ala Glu
165 170 175
gga tgg ttg ggc aag ctc atc gac atc ctg gcg att atc gcc acc gta 576
Gly Trp Leu Gly Lys Leu Ile Asp Ile Leu Ala Ile Ile Ala Thr Val
180 185 190
ttc ggc acg gca tgt tcc ctt ggc ctt ggt gcc ctg cag att ggt gca 624
Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gln Ile Gly Ala
195 200 205
ggc ctg tcc gca gca aac atc att gaa gat cca agc gat tgg acc atc 672
Gly Leu Ser Ala Ala Asn Ile Ile Glu Asp Pro Ser Asp Trp Thr Ile
210 215 220
gtt ggc att gtt tct gtt ttg acc ctg gca ttt atc ttc tcc gct att 720
Val Gly Ile Val Ser Val Leu Thr Leu Ala Phe Ile Phe Ser Ala Ile
225 230 235 240
tct ggt gtg ggc aag gga atc cag tac ctc tcc aac gcc aac atg gtt 768
Ser Gly Val Gly Lys Gly Ile Gln Tyr Leu Ser Asn Ala Asn Met Val
245 250 255
ctg gca gct ctg ctc gcg att ttc gtg ttc gtt gtc gga cca acc gtg 816
Leu Ala Ala Leu Leu Ala Ile Phe Val Phe Val Val Gly Pro Thr Val
260 265 270
tcg att ttg aac ctg ctg cca ggt tct att gtg aac tac ctg tcc aac 864
Ser Ile Leu Asn Leu Leu Pro Gly Ser Ile Val Asn Tyr Leu Ser Asn
275 280 285
ttc ttt caa atg gta ggc cgc act gcc atg agt gcc gac ggc aca cca 912
Phe Phe Gln Met Val Gly Arg Thr Ala Met Ser Ala Asp Gly Thr Pro
290 295 300
ggt gag tgg ctt ggt ggc tgc acc atc ttc tac 945
Gly Glu Trp Leu Gly Gly Cys Thr Ile Phe Tyr
305 310 315
<210> 454
<211> 315
<212> PRT
<213> Corynebacterium glutamicum
<400> 454
Ala Ser Leu Asn Trp Ser Val Ile Val Pro Ala Leu Val Ile Val Leu
1 5 10 15
Ala Thr Val Val Trp Gly Ile Gly Phe Lys Asp Ser Phe Thr Thr Phe
20 25 30
Ala Ser Ser Ala Leu Ser Ala Val Val Asp Asn Leu Gly Trp Ala Phe
35 40 45
Ile Leu Phe Gly Thr Val Phe Val Phe Phe Ile Val Val Ile Ala Ala
50 55 60
Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile Asp Glu Ala Pro Glu
65 70 75 80
Phe Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly Met Gly
85 90 95
Ile Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg
100 105 110
Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser
115 120 125
Thr Thr Met Phe His Trp Thr Leu His Pro Trp Ala Ile Tyr Ala Ile
130 135 140
Val Gly Leu Ala Ile Ala Tyr Ser Thr Phe Arg Val Gly Arg Lys Gln
145 150 155 160
Leu Leu Ser Ser Ala Phe Val Pro Leu Ile Gly Glu Lys Gly Ala Glu
165 170 175
Gly Trp Leu Gly Lys Leu Ile Asp Ile Leu Ala Ile Ile Ala Thr Val
180 185 190
Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gln Ile Gly Ala
195 200 205
Gly Leu Ser Ala Ala Asn Ile Ile Glu Asp Pro Ser Asp Trp Thr Ile
210 215 220
Val Gly Ile Val Ser Val Leu Thr Leu Ala Phe Ile Phe Ser Ala Ile
225 230 235 240
Ser Gly Val Gly Lys Gly Ile Gln Tyr Leu Ser Asn Ala Asn Met Val
245 250 255
Leu Ala Ala Leu Leu Ala Ile Phe Val Phe Val Val Gly Pro Thr Val
260 265 270
Ser Ile Leu Asn Leu Leu Pro Gly Ser Ile Val Asn Tyr Leu Ser Asn
275 280 285
Phe Phe Gln Met Val Gly Arg Thr Ala Met Ser Ala Asp Gly Thr Pro
290 295 300
Gly Glu Trp Leu Gly Gly Cys Thr Ile Phe Tyr
305 310 315
<210> 455
<211> 292
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(292)
<223> RXN00201
<400> 455
acgtcgcgga cttcaagtag tcggcgatga aaaagtccgt ttactaaacc ccgatctgtg 60
ttacgccatc gcgcggctcg ggcacaccga tacctgggca gtg gca gat tgc gga 115
Val Ala Asp Cys Gly
1 5
tta ccc atc cca gaa cac gta gag atc atc gat ttg gca ctc gtg ttt 163
Leu Pro Ile Pro Glu His Val Glu Ile Ile Asp Leu Ala Leu Val Phe
10 15 20
ggg atc ccc acc ttt gaa caa gta ctg aat gct ctc aag ccg gaa gta 211
Gly Ile Pro Thr Phe Glu Gln Val Leu Asn Ala Leu Lys Pro Glu Val
25 30 35
gtt gtg gaa ggc gcg gtg att gcc gaa ggg gca ccc caa cgt atc cgc 259
Val Val Glu Gly Ala Val Ile Ala Glu Gly Ala Pro Gln Arg Ile Arg
40 45 50
gaa atg gtg gat acg gat gtg gaa gta tgt gcg 292
Glu Met Val Asp Thr Asp Val Glu Val Cys Ala
55 60
<210> 456
<211> 64
<212> PRT
<213> Corynebacterium glutamicum
<400> 456
Val Ala Asp Cys Gly Leu Pro Ile Pro Glu His Val Glu Ile Ile Asp
1 5 10 15
Leu Ala Leu Val Phe Gly Ile Pro Thr Phe Glu Gln Val Leu Asn Ala
20 25 30
Leu Lys Pro Glu Val Val Val Glu Gly Ala Val Ile Ala Glu Gly Ala
35 40 45
Pro Gln Arg Ile Arg Glu Met Val Asp Thr Asp Val Glu Val Cys Ala
50 55 60
<210> 457
<211> 286
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(286)
<223> FRXA00201
<400> 457
acgtcgcgga cttcaagtag tcggcgatga aaaagtccgt ttactaaacc ccgatctgtg 60
ttacgccatc gcgcggctcg ggcacaccga tacctgggca gtg gca gat tgc gga 115
Val Ala Asp Cys Gly
1 5
tta ccc atc cca gaa cac gta gag atc atc gat ttg gca ctc gtg ttt 163
Leu Pro Ile Pro Glu His Val Glu Ile Ile Asp Leu Ala Leu Val Phe
10 15 20
ggg atc ccc acc ttt gaa caa gta ctg aat gct ctc aag ccg gaa gta 211
Gly Ile Pro Thr Phe Glu Gln Val Leu Asn Ala Leu Lys Pro Glu Val
25 30 35
gtt gtg gaa ggc gcg gtg att gcc gaa ggg gca ccc caa cgt atc cgc 259
Val Val Glu Gly Ala Val Ile Ala Glu Gly Ala Pro Gln Arg Ile Arg
40 45 50
gaa atg gtg gat acg gat gtg gaa gtt 286
Glu Met Val Asp Thr Asp Val Glu Val
55 60
<210> 458
<211> 62
<212> PRT
<213> Corynebacterium glutamicum
<400> 458
Val Ala Asp Cys Gly Leu Pro Ile Pro Glu His Val Glu Ile Ile Asp
1 5 10 15
Leu Ala Leu Val Phe Gly Ile Pro Thr Phe Glu Gln Val Leu Asn Ala
20 25 30
Leu Lys Pro Glu Val Val Val Glu Gly Ala Val Ile Ala Glu Gly Ala
35 40 45
Pro Gln Arg Ile Arg Glu Met Val Asp Thr Asp Val Glu Val
50 55 60
<210> 459
<211> 849
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(826)
<223> RXA01221
<400> 459
tccagggtgc gatcctggtt ctcgtgatcg tgttgctgcc gggcggaatt gcttcaatta 60
aactttccgc gctcaaaaat aaggccagga aggccacctc atg agc ctt aaa atc 115
Met Ser Leu Lys Ile
1 5
acc aac ctc aaa gtc gct ttc ggg tcg ttc atc gcc gtg aat gag att 163
Thr Asn Leu Lys Val Ala Phe Gly Ser Phe Ile Ala Val Asn Glu Ile
10 15 20
agt ttt cag gtg ctg ccc ggt cac gtc cac ttc ctc atc ggt gcc aac 211
Ser Phe Gln Val Leu Pro Gly His Val His Phe Leu Ile Gly Ala Asn
25 30 35
ggt gca ggt aaa acc acc tgc att gac gcg atc agc gga ttg gcg ccg 259
Gly Ala Gly Lys Thr Thr Cys Ile Asp Ala Ile Ser Gly Leu Ala Pro
40 45 50
ggg cag gga tca gtg cag ttg gat ggc act gag att ctg gga acc cct 307
Gly Gln Gly Ser Val Gln Leu Asp Gly Thr Glu Ile Leu Gly Thr Pro
55 60 65
gtg cac cgc att gct cgg atg ggt gtg ggg cga acg ttt cag acc gcc 355
Val His Arg Ile Ala Arg Met Gly Val Gly Arg Thr Phe Gln Thr Ala
70 75 80 85
agc gtg ttt gaa gaa ttg tct gtg ttg cag aat ctg gat att gcg tgc 403
Ser Val Phe Glu Glu Leu Ser Val Leu Gln Asn Leu Asp Ile Ala Cys
90 95 100
ggg att cat cgt ccg ttg cgg gcg ctt ctc ggg gtg cgt cat cgg att 451
Gly Ile His Arg Pro Leu Arg Ala Leu Leu Gly Val Arg His Arg Ile
105 110 115
gat ccc cga att gaa cac gcc ctg gag gtc acg ggt ctt gct gat ctg 499
Asp Pro Arg Ile Glu His Ala Leu Glu Val Thr Gly Leu Ala Asp Leu
120 125 130
gtg aat gct cag gcg gga acc ttg tcg cat ggg cag aaa cag tgg ctg 547
Val Asn Ala Gln Ala Gly Thr Leu Ser His Gly Gln Lys Gln Trp Leu
135 140 145
gaa att gca atg ttg ctg gtg cag gat gcg cag gtg ctc atg ctg gat 595
Glu Ile Ala Met Leu Leu Val Gln Asp Ala Gln Val Leu Met Leu Asp
150 155 160 165
gag ccg gtg gcg ggc atg agt gag gag gag cgt gtc gca acg ggt gag 643
Glu Pro Val Ala Gly Met Ser Glu Glu Glu Arg Val Ala Thr Gly Glu
170 175 180
ctt ttg cag agg gtt gcg cgg gga cgg gtg gtg ttg gtg gtg gag cac 691
Leu Leu Gln Arg Val Ala Arg Gly Arg Val Val Leu Val Val Glu His
185 190 195
gat atg gag ttc atg cgt cgt ttt gcc act cgc gtc act gtg atg aat 739
Asp Met Glu Phe Met Arg Arg Phe Ala Thr Arg Val Thr Val Met Asn
200 205 210
cgc ggc acg atc ttg tgt gag ggg tcg gtc gat gag att cag gcg aat 787
Arg Gly Thr Ile Leu Cys Glu Gly Ser Val Asp Glu Ile Gln Ala Asn
215 220 225
ccg gat gtg cag tcc att tat tta ggt acg gca ggg aag tgagttagtc 836
Pro Asp Val Gln Ser Ile Tyr Leu Gly Thr Ala Gly Lys
230 235 240
atgttggaaa tca 849
<210> 460
<211> 242
<212> PRT
<213> Corynebacterium glutamicum
<400> 460
Met Ser Leu Lys Ile Thr Asn Leu Lys Val Ala Phe Gly Ser Phe Ile
1 5 10 15
Ala Val Asn Glu Ile Ser Phe Gln Val Leu Pro Gly His Val His Phe
20 25 30
Leu Ile Gly Ala Asn Gly Ala Gly Lys Thr Thr Cys Ile Asp Ala Ile
35 40 45
Ser Gly Leu Ala Pro Gly Gln Gly Ser Val Gln Leu Asp Gly Thr Glu
50 55 60
Ile Leu Gly Thr Pro Val His Arg Ile Ala Arg Met Gly Val Gly Arg
65 70 75 80
Thr Phe Gln Thr Ala Ser Val Phe Glu Glu Leu Ser Val Leu Gln Asn
85 90 95
Leu Asp Ile Ala Cys Gly Ile His Arg Pro Leu Arg Ala Leu Leu Gly
100 105 110
Val Arg His Arg Ile Asp Pro Arg Ile Glu His Ala Leu Glu Val Thr
115 120 125
Gly Leu Ala Asp Leu Val Asn Ala Gln Ala Gly Thr Leu Ser His Gly
130 135 140
Gln Lys Gln Trp Leu Glu Ile Ala Met Leu Leu Val Gln Asp Ala Gln
145 150 155 160
Val Leu Met Leu Asp Glu Pro Val Ala Gly Met Ser Glu Glu Glu Arg
165 170 175
Val Ala Thr Gly Glu Leu Leu Gln Arg Val Ala Arg Gly Arg Val Val
180 185 190
Leu Val Val Glu His Asp Met Glu Phe Met Arg Arg Phe Ala Thr Arg
195 200 205
Val Thr Val Met Asn Arg Gly Thr Ile Leu Cys Glu Gly Ser Val Asp
210 215 220
Glu Ile Gln Ala Asn Pro Asp Val Gln Ser Ile Tyr Leu Gly Thr Ala
225 230 235 240
Gly Lys
<210> 461
<211> 822
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(799)
<223> RXA01222
<400> 461
aatcgcggca cgatcttgtg tgaggggtcg gtcgatgaga ttcaggcgaa tccggatgtg 60
cagtccattt atttaggtac ggcagggaag tgagttagtc atg ttg gaa atc act 115
Met Leu Glu Ile Thr
1 5
aat ttg tgt gca ggt tat ggc cgc acg cag gta ctt cat tct ctt tca 163
Asn Leu Cys Ala Gly Tyr Gly Arg Thr Gln Val Leu His Ser Leu Ser
10 15 20
atc tcc acg agc agc aac ggc atc ctg tcg atc ctc ggc cac aat ggc 211
Ile Ser Thr Ser Ser Asn Gly Ile Leu Ser Ile Leu Gly His Asn Gly
25 30 35
gct ggt aaa tcc acc ttg ctg cga acc gcg gtg ggg ttg att aag ccg 259
Ala Gly Lys Ser Thr Leu Leu Arg Thr Ala Val Gly Leu Ile Lys Pro
40 45 50
act tcc gga gag gtc aaa ctt ttc ggc cag gat gtc acc tcg ttg tcc 307
Thr Ser Gly Glu Val Lys Leu Phe Gly Gln Asp Val Thr Ser Leu Ser
55 60 65
acg cat gag cga gta aag cgc gga atg gct tat gtg ccg cag ggc cag 355
Thr His Glu Arg Val Lys Arg Gly Met Ala Tyr Val Pro Gln Gly Gln
70 75 80 85
cag tct ttt acg cag ctt agt tgc atg gaa aat ttg cag gtg gta gcg 403
Gln Ser Phe Thr Gln Leu Ser Cys Met Glu Asn Leu Gln Val Val Ala
90 95 100
gat ctg cag gga cgt gtg ggc aag gca cgc atc gcg gag gcg ctt gat 451
Asp Leu Gln Gly Arg Val Gly Lys Ala Arg Ile Ala Glu Ala Leu Asp
105 110 115
cgc ttt ccg gcg ctg acc cag gtg ctg gac cgc caa gcc ggc ctg ttg 499
Arg Phe Pro Ala Leu Thr Gln Val Leu Asp Arg Gln Ala Gly Leu Leu
120 125 130
tcg ggt ggt cag cgt cag cag ctt gcc atc gcc cgc gcg ctg atc acg 547
Ser Gly Gly Gln Arg Gln Gln Leu Ala Ile Ala Arg Ala Leu Ile Thr
135 140 145
gcg cca aag ctt ttg ctt ctc gac gaa ccc acc gag ggt att cag cct 595
Ala Pro Lys Leu Leu Leu Leu Asp Glu Pro Thr Glu Gly Ile Gln Pro
150 155 160 165
tcg gtg gtt gct gaa att cag cag acc atc atc gat ttg gct aag gac 643
Ser Val Val Ala Glu Ile Gln Gln Thr Ile Ile Asp Leu Ala Lys Asp
170 175 180
ggc atg agc att gtc ctg gtg gag caa aac att ggt ttt gca ttg gat 691
Gly Met Ser Ile Val Leu Val Glu Gln Asn Ile Gly Phe Ala Leu Asp
185 190 195
gct gca aca agc tac gcc att gtg gcg cgt ggt cag gtc gtg gaa tcg 739
Ala Ala Thr Ser Tyr Ala Ile Val Ala Arg Gly Gln Val Val Glu Ser
200 205 210
gga caa ggc gct gaa acc acc gca gag aag cag act aaa gtg cgg gaa 787
Gly Gln Gly Ala Glu Thr Thr Ala Glu Lys Gln Thr Lys Val Arg Glu
215 220 225
tct cta gca atc tagcggctgt ggatagcgtt ttg 822
Ser Leu Ala Ile
230
<210> 462
<211> 233
<212> PRT
<213> Corynebacterium glutamicum
<400> 462
Met Leu Glu Ile Thr Asn Leu Cys Ala Gly Tyr Gly Arg Thr Gln Val
1 5 10 15
Leu His Ser Leu Ser Ile Ser Thr Ser Ser Asn Gly Ile Leu Ser Ile
20 25 30
Leu Gly His Asn Gly Ala Gly Lys Ser Thr Leu Leu Arg Thr Ala Val
35 40 45
Gly Leu Ile Lys Pro Thr Ser Gly Glu Val Lys Leu Phe Gly Gln Asp
50 55 60
Val Thr Ser Leu Ser Thr His Glu Arg Val Lys Arg Gly Met Ala Tyr
65 70 75 80
Val Pro Gln Gly Gln Gln Ser Phe Thr Gln Leu Ser Cys Met Glu Asn
85 90 95
Leu Gln Val Val Ala Asp Leu Gln Gly Arg Val Gly Lys Ala Arg Ile
100 105 110
Ala Glu Ala Leu Asp Arg Phe Pro Ala Leu Thr Gln Val Leu Asp Arg
115 120 125
Gln Ala Gly Leu Leu Ser Gly Gly Gln Arg Gln Gln Leu Ala Ile Ala
130 135 140
Arg Ala Leu Ile Thr Ala Pro Lys Leu Leu Leu Leu Asp Glu Pro Thr
145 150 155 160
Glu Gly Ile Gln Pro Ser Val Val Ala Glu Ile Gln Gln Thr Ile Ile
165 170 175
Asp Leu Ala Lys Asp Gly Met Ser Ile Val Leu Val Glu Gln Asn Ile
180 185 190
Gly Phe Ala Leu Asp Ala Ala Thr Ser Tyr Ala Ile Val Ala Arg Gly
195 200 205
Gln Val Val Glu Ser Gly Gln Gly Ala Glu Thr Thr Ala Glu Lys Gln
210 215 220
Thr Lys Val Arg Glu Ser Leu Ala Ile
225 230
<210> 463
<211> 1005
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(982)
<223> RXA01219
<400> 463
caccatttgg gaaaccgatt ccccagttga tccggaccca tacttgtctt cctatgactg 60
ggccaagacc accgctgcga cttcctaaga gataaaaatc atg gac att tta ctc 115
Met Asp Ile Leu Leu
1 5
aat cag ctc gta gcc ggg ctt tca gtt gga tcg gtc ctt cta ttg gtc 163
Asn Gln Leu Val Ala Gly Leu Ser Val Gly Ser Val Leu Leu Leu Val
10 15 20
gca gtg gga ttg tca ctg acc ttt gga cag atg ggc gtt att aat atg 211
Ala Val Gly Leu Ser Leu Thr Phe Gly Gln Met Gly Val Ile Asn Met
25 30 35
gcg cac gga gag ttc atc atg gtc ggc gca tac acc gca tat gtg gtg 259
Ala His Gly Glu Phe Ile Met Val Gly Ala Tyr Thr Ala Tyr Val Val
40 45 50
cag ctg gtc gtc ggt tct gcc ggt tta tcc cta ctg atc agc att ccg 307
Gln Leu Val Val Gly Ser Ala Gly Leu Ser Leu Leu Ile Ser Ile Pro
55 60 65
ctg gcc ttt att atc ggt ggg ctt ttc gga gtt ctc ctc gaa caa ttc 355
Leu Ala Phe Ile Ile Gly Gly Leu Phe Gly Val Leu Leu Glu Gln Phe
70 75 80 85
ctg ctg aag tat ctt tat cac agg cca cta gac acg ctg ctg gcc aca 403
Leu Leu Lys Tyr Leu Tyr His Arg Pro Leu Asp Thr Leu Leu Ala Thr
90 95 100
ttc ggt gtc ggt ttg atc ctt cag cag ctg gcc cga aac att ttc gga 451
Phe Gly Val Gly Leu Ile Leu Gln Gln Leu Ala Arg Asn Ile Phe Gly
105 110 115
gct ccc gca gtg gat gtc agg gca ccg gaa ttt ctc cgc gga aac gtc 499
Ala Pro Ala Val Asp Val Arg Ala Pro Glu Phe Leu Arg Gly Asn Val
120 125 130
gaa gtt cta ggc gtc ttg gtg ccg acc gcg cga cta ttc atc ctg gcg 547
Glu Val Leu Gly Val Leu Val Pro Thr Ala Arg Leu Phe Ile Leu Ala
135 140 145
ctg gcc atc gca tca gtg act gca cta gct gtg ttc cta aat cgc act 595
Leu Ala Ile Ala Ser Val Thr Ala Leu Ala Val Phe Leu Asn Arg Thr
150 155 160 165
gcc tgg ggc cga cgc atc cgc gcc gtg gtt ctg aac cgc gac ctc gcg 643
Ala Trp Gly Arg Arg Ile Arg Ala Val Val Leu Asn Arg Asp Leu Ala
170 175 180
gaa acc gca ggt att gat acc cga gct act gac cga atg acg ttc ttt 691
Glu Thr Ala Gly Ile Asp Thr Arg Ala Thr Asp Arg Met Thr Phe Phe
185 190 195
gtg ggc tcc ggt ctt gcc gga atc gcc ggg gta gct atc aca ttg att 739
Val Gly Ser Gly Leu Ala Gly Ile Ala Gly Val Ala Ile Thr Leu Ile
200 205 210
ggc gcg acc ggc ccc acc atc ggt cag aac tac atc gtg gat gcc ttc 787
Gly Ala Thr Gly Pro Thr Ile Gly Gln Asn Tyr Ile Val Asp Ala Phe
215 220 225
ctt gtt gtt gcc gcc ggt ggc atc ggc cgg gtg aag ggc gct gtg atc 835
Leu Val Val Ala Ala Gly Gly Ile Gly Arg Val Lys Gly Ala Val Ile
230 235 240 245
atg gct ttc gtg ctg gga att act caa gca ttc gtg gaa tat acg aca 883
Met Ala Phe Val Leu Gly Ile Thr Gln Ala Phe Val Glu Tyr Thr Thr
250 255 260
ggt gcg agc atc gcg aag ttc atc gta ctc atc gct gtt gtt gcc ttc 931
Gly Ala Ser Ile Ala Lys Phe Ile Val Leu Ile Ala Val Val Ala Phe
265 270 275
ctg cag ttt agg cct caa gga ctc ttc caa acc caa act agg agc ctc 979
Leu Gln Phe Arg Pro Gln Gly Leu Phe Gln Thr Gln Thr Arg Ser Leu
280 285 290
gta tgagcactca actcaagctg aag 1005
Val
<210> 464
<211> 294
<212> PRT
<213> Corynebacterium glutamicum
<400> 464
Met Asp Ile Leu Leu Asn Gln Leu Val Ala Gly Leu Ser Val Gly Ser
1 5 10 15
Val Leu Leu Leu Val Ala Val Gly Leu Ser Leu Thr Phe Gly Gln Met
20 25 30
Gly Val Ile Asn Met Ala His Gly Glu Phe Ile Met Val Gly Ala Tyr
35 40 45
Thr Ala Tyr Val Val Gln Leu Val Val Gly Ser Ala Gly Leu Ser Leu
50 55 60
Leu Ile Ser Ile Pro Leu Ala Phe Ile Ile Gly Gly Leu Phe Gly Val
65 70 75 80
Leu Leu Glu Gln Phe Leu Leu Lys Tyr Leu Tyr His Arg Pro Leu Asp
85 90 95
Thr Leu Leu Ala Thr Phe Gly Val Gly Leu Ile Leu Gln Gln Leu Ala
100 105 110
Arg Asn Ile Phe Gly Ala Pro Ala Val Asp Val Arg Ala Pro Glu Phe
115 120 125
Leu Arg Gly Asn Val Glu Val Leu Gly Val Leu Val Pro Thr Ala Arg
130 135 140
Leu Phe Ile Leu Ala Leu Ala Ile Ala Ser Val Thr Ala Leu Ala Val
145 150 155 160
Phe Leu Asn Arg Thr Ala Trp Gly Arg Arg Ile Arg Ala Val Val Leu
165 170 175
Asn Arg Asp Leu Ala Glu Thr Ala Gly Ile Asp Thr Arg Ala Thr Asp
180 185 190
Arg Met Thr Phe Phe Val Gly Ser Gly Leu Ala Gly Ile Ala Gly Val
195 200 205
Ala Ile Thr Leu Ile Gly Ala Thr Gly Pro Thr Ile Gly Gln Asn Tyr
210 215 220
Ile Val Asp Ala Phe Leu Val Val Ala Ala Gly Gly Ile Gly Arg Val
225 230 235 240
Lys Gly Ala Val Ile Met Ala Phe Val Leu Gly Ile Thr Gln Ala Phe
245 250 255
Val Glu Tyr Thr Thr Gly Ala Ser Ile Ala Lys Phe Ile Val Leu Ile
260 265 270
Ala Val Val Ala Phe Leu Gln Phe Arg Pro Gln Gly Leu Phe Gln Thr
275 280 285
Gln Thr Arg Ser Leu Val
290
<210> 465
<211> 1200
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1177)
<223> RXA01220
<400> 465
caggtgcgag catcgcgaag ttcatcgtac tcatcgctgt tgttgccttc ctgcagttta 60
ggcctcaagg actcttccaa acccaaacta ggagcctcgt atg agc act caa ctc 115
Met Ser Thr Gln Leu
1 5
aag ctg aag aag ccc gca aag aag aaa act acg ccg aaa ctt agc gtc 163
Lys Leu Lys Lys Pro Ala Lys Lys Lys Thr Thr Pro Lys Leu Ser Val
10 15 20
gta aat gct ccc acg ctg cgc act gcg gcg ttg ggc ctg gcc gcg ctc 211
Val Asn Ala Pro Thr Leu Arg Thr Ala Ala Leu Gly Leu Ala Ala Leu
25 30 35
gct gcg gta ttg ctg tgc gcc ccg ctc ttt tta tcc aca ttc cag ctg 259
Ala Ala Val Leu Leu Cys Ala Pro Leu Phe Leu Ser Thr Phe Gln Leu
40 45 50
acg ttg atg tcg cgc ttg gtg tgt tat gcg atc gtc gca gtc ggc atc 307
Thr Leu Met Ser Arg Leu Val Cys Tyr Ala Ile Val Ala Val Gly Ile
55 60 65
ggg ctg gcg tgg ggc aga ggc ggc atg ctc acg ctg ggg caa ggc gtg 355
Gly Leu Ala Trp Gly Arg Gly Gly Met Leu Thr Leu Gly Gln Gly Val
70 75 80 85
ttc ttt gga atc ggc gcg tac atc atg gcc atg cac atg ctg tac agc 403
Phe Phe Gly Ile Gly Ala Tyr Ile Met Ala Met His Met Leu Tyr Ser
90 95 100
gat tcg cag att ttt ggg acc aca gtt ccg caa tgg tgg tcc att ttt 451
Asp Ser Gln Ile Phe Gly Thr Thr Val Pro Gln Trp Trp Ser Ile Phe
105 110 115
gcc aac ccg gca gtc gca ctc atc gca gtt gtg gcg ctt ccc ggc atc 499
Ala Asn Pro Ala Val Ala Leu Ile Ala Val Val Ala Leu Pro Gly Ile
120 125 130
gtg gct ttt gtg ctc ggc ttc tcc att ttc aaa cga cgc atc aaa ggc 547
Val Ala Phe Val Leu Gly Phe Ser Ile Phe Lys Arg Arg Ile Lys Gly
135 140 145
gcc tac ttt gcc atc gtg aac caa gcg ctc gcc gca gct gtt gtg gtg 595
Ala Tyr Phe Ala Ile Val Asn Gln Ala Leu Ala Ala Ala Val Val Val
150 155 160 165
ttg ctg gtc gga caa caa gat tcc ctt gga ggt tcc aat ggt ctt tcc 643
Leu Leu Val Gly Gln Gln Asp Ser Leu Gly Gly Ser Asn Gly Leu Ser
170 175 180
gga ttt cga tcg ttc atg ggt ttt gcc gtc tac gac ccc atc aac cgc 691
Gly Phe Arg Ser Phe Met Gly Phe Ala Val Tyr Asp Pro Ile Asn Arg
185 190 195
atc atg ttt tac ttc acc gca gtg gga gtt ctc ttg gct ttg gtg gct 739
Ile Met Phe Tyr Phe Thr Ala Val Gly Val Leu Leu Ala Leu Val Ala
200 205 210
atc tca tat tgg ctc atg cgc agc cgc tat gga gaa ctg ctc gtg gcc 787
Ile Ser Tyr Trp Leu Met Arg Ser Arg Tyr Gly Glu Leu Leu Val Ala
215 220 225
acc aga gat gca gaa gaa cgc gtc cga ttc ctc gga tat gat ccc gca 835
Thr Arg Asp Ala Glu Glu Arg Val Arg Phe Leu Gly Tyr Asp Pro Ala
230 235 240 245
ttg atc aaa acc gcc gca tat gtc att gct gcg atg att gcc gga atc 883
Leu Ile Lys Thr Ala Ala Tyr Val Ile Ala Ala Met Ile Ala Gly Ile
250 255 260
gcc gga gcg ctg ttc gtg ccg atc gtg ggc atc att tca ccc gca gaa 931
Ala Gly Ala Leu Phe Val Pro Ile Val Gly Ile Ile Ser Pro Ala Glu
265 270 275
atc ggc gtg gtg cca tca atc gtg ttc gtg atc gcc gtc gcc gct ggt 979
Ile Gly Val Val Pro Ser Ile Val Phe Val Ile Ala Val Ala Ala Gly
280 285 290
ggc agg gca tcc cta ttc ggt ccc gta gtt ggc gcg ctg gtg ctg ggc 1027
Gly Arg Ala Ser Leu Phe Gly Pro Val Val Gly Ala Leu Val Leu Gly
295 300 305
tgg gtg gaa tcc aca ctt gct caa act ttc ccc agc atg tgg tcc tat 1075
Trp Val Glu Ser Thr Leu Ala Gln Thr Phe Pro Ser Met Trp Ser Tyr
310 315 320 325
ttc cag ggt gcg atc ctg gtt ctc gtg atc gtg ttg ctg ccg ggc gga 1123
Phe Gln Gly Ala Ile Leu Val Leu Val Ile Val Leu Leu Pro Gly Gly
330 335 340
att gct tca att aaa ctt tcc gcg ctc aaa aat aag gcc agg aag gcc 1171
Ile Ala Ser Ile Lys Leu Ser Ala Leu Lys Asn Lys Ala Arg Lys Ala
345 350 355
acc tca tgagccttaa aatcaccaac ctc 1200
Thr Ser
<210> 466
<211> 359
<212> PRT
<213> Corynebacterium glutamicum
<400> 466
Met Ser Thr Gln Leu Lys Leu Lys Lys Pro Ala Lys Lys Lys Thr Thr
1 5 10 15
Pro Lys Leu Ser Val Val Asn Ala Pro Thr Leu Arg Thr Ala Ala Leu
20 25 30
Gly Leu Ala Ala Leu Ala Ala Val Leu Leu Cys Ala Pro Leu Phe Leu
35 40 45
Ser Thr Phe Gln Leu Thr Leu Met Ser Arg Leu Val Cys Tyr Ala Ile
50 55 60
Val Ala Val Gly Ile Gly Leu Ala Trp Gly Arg Gly Gly Met Leu Thr
65 70 75 80
Leu Gly Gln Gly Val Phe Phe Gly Ile Gly Ala Tyr Ile Met Ala Met
85 90 95
His Met Leu Tyr Ser Asp Ser Gln Ile Phe Gly Thr Thr Val Pro Gln
100 105 110
Trp Trp Ser Ile Phe Ala Asn Pro Ala Val Ala Leu Ile Ala Val Val
115 120 125
Ala Leu Pro Gly Ile Val Ala Phe Val Leu Gly Phe Ser Ile Phe Lys
130 135 140
Arg Arg Ile Lys Gly Ala Tyr Phe Ala Ile Val Asn Gln Ala Leu Ala
145 150 155 160
Ala Ala Val Val Val Leu Leu Val Gly Gln Gln Asp Ser Leu Gly Gly
165 170 175
Ser Asn Gly Leu Ser Gly Phe Arg Ser Phe Met Gly Phe Ala Val Tyr
180 185 190
Asp Pro Ile Asn Arg Ile Met Phe Tyr Phe Thr Ala Val Gly Val Leu
195 200 205
Leu Ala Leu Val Ala Ile Ser Tyr Trp Leu Met Arg Ser Arg Tyr Gly
210 215 220
Glu Leu Leu Val Ala Thr Arg Asp Ala Glu Glu Arg Val Arg Phe Leu
225 230 235 240
Gly Tyr Asp Pro Ala Leu Ile Lys Thr Ala Ala Tyr Val Ile Ala Ala
245 250 255
Met Ile Ala Gly Ile Ala Gly Ala Leu Phe Val Pro Ile Val Gly Ile
260 265 270
Ile Ser Pro Ala Glu Ile Gly Val Val Pro Ser Ile Val Phe Val Ile
275 280 285
Ala Val Ala Ala Gly Gly Arg Ala Ser Leu Phe Gly Pro Val Val Gly
290 295 300
Ala Leu Val Leu Gly Trp Val Glu Ser Thr Leu Ala Gln Thr Phe Pro
305 310 315 320
Ser Met Trp Ser Tyr Phe Gln Gly Ala Ile Leu Val Leu Val Ile Val
325 330 335
Leu Leu Pro Gly Gly Ile Ala Ser Ile Lys Leu Ser Ala Leu Lys Asn
340 345 350
Lys Ala Arg Lys Ala Thr Ser
355
<210> 467
<211> 876
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(853)
<223> RXA00091
<400> 467
tcatgaacca cgtgttccgc gcacaaggcg tcgtgtccat cattattgag atggtcggcg 60
gtaccgtctt cctcatcgtc atcctcagaa agggcagact gtg att acg tta act 115
Val Ile Thr Leu Thr
1 5
aat gtc cgc aag gaa tac tcc agc gac gtt gcc atc ggc ccc gtc aac 163
Asn Val Arg Lys Glu Tyr Ser Ser Asp Val Ala Ile Gly Pro Val Asn
10 15 20
ctt gag atc cca gcc ggc ggc atc acc gcg ttg gtc ggc cca aac ggt 211
Leu Glu Ile Pro Ala Gly Gly Ile Thr Ala Leu Val Gly Pro Asn Gly
25 30 35
gca ggc aag tca aca ctg ctc acc atg atc ggt cga ctc ctc ggc atc 259
Ala Gly Lys Ser Thr Leu Leu Thr Met Ile Gly Arg Leu Leu Gly Ile
40 45 50
gat gaa ggc aac atc acc gta gcc tcc tac gat gtc acc tca acc gca 307
Asp Glu Gly Asn Ile Thr Val Ala Ser Tyr Asp Val Thr Ser Thr Ala
55 60 65
tcc aaa gat ctg gcc aag atc atc tcc atc ctg cgc cag gaa aac cac 355
Ser Lys Asp Leu Ala Lys Ile Ile Ser Ile Leu Arg Gln Glu Asn His
70 75 80 85
ttt gtt acc aag ctg acc gtg cgc cag ctc gta ggt ttc gga cgc ttc 403
Phe Val Thr Lys Leu Thr Val Arg Gln Leu Val Gly Phe Gly Arg Phe
90 95 100
cca tat agc aag ggc cgg ctg acg gaa gaa gac gag gga atc atc tcc 451
Pro Tyr Ser Lys Gly Arg Leu Thr Glu Glu Asp Glu Gly Ile Ile Ser
105 110 115
cgc tac atc gac ttc ttc aat ctc acc gaa ctc gaa gac cgc tac ctc 499
Arg Tyr Ile Asp Phe Phe Asn Leu Thr Glu Leu Glu Asp Arg Tyr Leu
120 125 130
gac cag ctt tcc ggc ggc cag cgc cag cgc gcc tat gtc gcc atg gtg 547
Asp Gln Leu Ser Gly Gly Gln Arg Gln Arg Ala Tyr Val Ala Met Val
135 140 145
ctg tgc caa gag acg gac tac gtg ctt ctc gac gaa ccc ctc aac aat 595
Leu Cys Gln Glu Thr Asp Tyr Val Leu Leu Asp Glu Pro Leu Asn Asn
150 155 160 165
ctt gat atc gca cac tcg gtg gaa atg atg aaa cac ctc gag aat gct 643
Leu Asp Ile Ala His Ser Val Glu Met Met Lys His Leu Glu Asn Ala
170 175 180
gca gcc caa ttt ggc cgc acc atc atc gtg gtt ctt cac gac atc aac 691
Ala Ala Gln Phe Gly Arg Thr Ile Ile Val Val Leu His Asp Ile Asn
185 190 195
ttc gcc gcg cgc tac gcc gat tac atc gtg gcc gta aag cac gga atg 739
Phe Ala Ala Arg Tyr Ala Asp Tyr Ile Val Ala Val Lys His Gly Met
200 205 210
atc gaa aaa gag gga aca cct gaa cag atc atg aaa aac gag atc ctt 787
Ile Glu Lys Glu Gly Thr Pro Glu Gln Ile Met Lys Asn Glu Ile Leu
215 220 225
tca gaa atc ttc aat aca gag atc gaa gtt att gaa gga cca cac ggc 835
Ser Glu Ile Phe Asn Thr Glu Ile Glu Val Ile Glu Gly Pro His Gly
230 235 240 245
aag att gct tgc tac cac taaatgaaga gaaataagcc gac 876
Lys Ile Ala Cys Tyr His
250
<210> 468
<211> 251
<212> PRT
<213> Corynebacterium glutamicum
<400> 468
Val Ile Thr Leu Thr Asn Val Arg Lys Glu Tyr Ser Ser Asp Val Ala
1 5 10 15
Ile Gly Pro Val Asn Leu Glu Ile Pro Ala Gly Gly Ile Thr Ala Leu
20 25 30
Val Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu Leu Thr Met Ile Gly
35 40 45
Arg Leu Leu Gly Ile Asp Glu Gly Asn Ile Thr Val Ala Ser Tyr Asp
50 55 60
Val Thr Ser Thr Ala Ser Lys Asp Leu Ala Lys Ile Ile Ser Ile Leu
65 70 75 80
Arg Gln Glu Asn His Phe Val Thr Lys Leu Thr Val Arg Gln Leu Val
85 90 95
Gly Phe Gly Arg Phe Pro Tyr Ser Lys Gly Arg Leu Thr Glu Glu Asp
100 105 110
Glu Gly Ile Ile Ser Arg Tyr Ile Asp Phe Phe Asn Leu Thr Glu Leu
115 120 125
Glu Asp Arg Tyr Leu Asp Gln Leu Ser Gly Gly Gln Arg Gln Arg Ala
130 135 140
Tyr Val Ala Met Val Leu Cys Gln Glu Thr Asp Tyr Val Leu Leu Asp
145 150 155 160
Glu Pro Leu Asn Asn Leu Asp Ile Ala His Ser Val Glu Met Met Lys
165 170 175
His Leu Glu Asn Ala Ala Ala Gln Phe Gly Arg Thr Ile Ile Val Val
180 185 190
Leu His Asp Ile Asn Phe Ala Ala Arg Tyr Ala Asp Tyr Ile Val Ala
195 200 205
Val Lys His Gly Met Ile Glu Lys Glu Gly Thr Pro Glu Gln Ile Met
210 215 220
Lys Asn Glu Ile Leu Ser Glu Ile Phe Asn Thr Glu Ile Glu Val Ile
225 230 235 240
Glu Gly Pro His Gly Lys Ile Ala Cys Tyr His
245 250
<210> 469
<211> 692
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (79)..(669)
<223> RXA00228
<400> 469
ccgcatggca tccgccgaaa gaattcccct ccggaggaat ggcacgcctc atgggagaac 60
gcatcggcaa aaactgac atg cgc gac ctc cgc tcc atg atc ggc gtc agc 111
Met Arg Asp Leu Arg Ser Met Ile Gly Val Ser
1 5 10
tcc tcc gca tta ggc aac cga atc ccc tcc gaa gaa aaa gtc tct gac 159
Ser Ser Ala Leu Gly Asn Arg Ile Pro Ser Glu Glu Lys Val Ser Asp
15 20 25
cta gtc atc tcc gca ggc tac gca atc ctc ggc cgc tgg cgc gaa gac 207
Leu Val Ile Ser Ala Gly Tyr Ala Ile Leu Gly Arg Trp Arg Glu Asp
30 35 40
tac gac gaa atg gac ttc gga caa gcc acc gaa atc ctc gaa caa gtc 255
Tyr Asp Glu Met Asp Phe Gly Gln Ala Thr Glu Ile Leu Glu Gln Val
45 50 55
gga gcc atg cac cta gcc gac cgc acc tgg gga acc ctc tcc gaa ggc 303
Gly Ala Met His Leu Ala Asp Arg Thr Trp Gly Thr Leu Ser Glu Gly
60 65 70 75
gaa cgc aaa cga gtc ctg gtc gca cgc gca ctc atg acc aac ccg gaa 351
Glu Arg Lys Arg Val Leu Val Ala Arg Ala Leu Met Thr Asn Pro Glu
80 85 90
ctc ctc atc ctt gac gaa cca acc gca gga atg gac ctc ggc gga cgc 399
Leu Leu Ile Leu Asp Glu Pro Thr Ala Gly Met Asp Leu Gly Gly Arg
95 100 105
gaa gac ctc gtc ggc tac ctc gga gaa ctc gcc atg gac cca gac gca 447
Glu Asp Leu Val Gly Tyr Leu Gly Glu Leu Ala Met Asp Pro Asp Ala
110 115 120
cct gcc atc gtc atg atc acc cac cac gtc gaa gaa atc ccc gcc gga 495
Pro Ala Ile Val Met Ile Thr His His Val Glu Glu Ile Pro Ala Gly
125 130 135
ttc acc cac gca atg ctc ctc gac gaa ggt gaa atc gta gcc caa ggc 543
Phe Thr His Ala Met Leu Leu Asp Glu Gly Glu Ile Val Ala Gln Gly
140 145 150 155
ctg atc aac acc gtc atg aca aac gag aac cta tcc aaa gca ttc cac 591
Leu Ile Asn Thr Val Met Thr Asn Glu Asn Leu Ser Lys Ala Phe His
160 165 170
cag cca atc caa gta gac cgc atc ggg gaa cgc tac ttt gcc cgc cgt 639
Gln Pro Ile Gln Val Asp Arg Ile Gly Glu Arg Tyr Phe Ala Arg Arg
175 180 185
gtg aga acc gcc agg agt cat agg gct cag taggtttttt ggagttgtgg 689
Val Arg Thr Ala Arg Ser His Arg Ala Gln
190 195
gcc 692
<210> 470
<211> 197
<212> PRT
<213> Corynebacterium glutamicum
<400> 470
Met Arg Asp Leu Arg Ser Met Ile Gly Val Ser Ser Ser Ala Leu Gly
1 5 10 15
Asn Arg Ile Pro Ser Glu Glu Lys Val Ser Asp Leu Val Ile Ser Ala
20 25 30
Gly Tyr Ala Ile Leu Gly Arg Trp Arg Glu Asp Tyr Asp Glu Met Asp
35 40 45
Phe Gly Gln Ala Thr Glu Ile Leu Glu Gln Val Gly Ala Met His Leu
50 55 60
Ala Asp Arg Thr Trp Gly Thr Leu Ser Glu Gly Glu Arg Lys Arg Val
65 70 75 80
Leu Val Ala Arg Ala Leu Met Thr Asn Pro Glu Leu Leu Ile Leu Asp
85 90 95
Glu Pro Thr Ala Gly Met Asp Leu Gly Gly Arg Glu Asp Leu Val Gly
100 105 110
Tyr Leu Gly Glu Leu Ala Met Asp Pro Asp Ala Pro Ala Ile Val Met
115 120 125
Ile Thr His His Val Glu Glu Ile Pro Ala Gly Phe Thr His Ala Met
130 135 140
Leu Leu Asp Glu Gly Glu Ile Val Ala Gln Gly Leu Ile Asn Thr Val
145 150 155 160
Met Thr Asn Glu Asn Leu Ser Lys Ala Phe His Gln Pro Ile Gln Val
165 170 175
Asp Arg Ile Gly Glu Arg Tyr Phe Ala Arg Arg Val Arg Thr Ala Arg
180 185 190
Ser His Arg Ala Gln
195
<210> 471
<211> 813
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(790)
<223> RXA00346
<400> 471
atctatgaga cccctcaaaa caccgagaat ttcctcgatg cattcaccaa ggcagttgat 60
gatctcaccg ctgccactaa ccaggtttag aattatttaa atg ctg ttg act ttc 115
Met Leu Leu Thr Phe
1 5
aat gat gct gcg gtg gat ccc ctc tgg agg ggc ctg aat tta gag ctc 163
Asn Asp Ala Ala Val Asp Pro Leu Trp Arg Gly Leu Asn Leu Glu Leu
10 15 20
cga cag ggg gaa ttt ctt gcg gtt tta ggc ccc aac ggc gtg gga aaa 211
Arg Gln Gly Glu Phe Leu Ala Val Leu Gly Pro Asn Gly Val Gly Lys
25 30 35
tcc acg ctc atc ggt acg att ttg ggc acc cga aaa ctc acc cac ggt 259
Ser Thr Leu Ile Gly Thr Ile Leu Gly Thr Arg Lys Leu Thr His Gly
40 45 50
tcg gtt aaa act gat gcc cgg gtg ggt tat att ccg caa caa cga att 307
Ser Val Lys Thr Asp Ala Arg Val Gly Tyr Ile Pro Gln Gln Arg Ile
55 60 65
ttc gat gtc ccg ttg cgt gcc cgc gat atg gtt tcg ctg tcc gcg gcg 355
Phe Asp Val Pro Leu Arg Ala Arg Asp Met Val Ser Leu Ser Ala Ala
70 75 80 85
cat ggc gtg gtt tcc aaa agg gga ccc gcg aag ggt gac gtc gat aag 403
His Gly Val Val Ser Lys Arg Gly Pro Ala Lys Gly Asp Val Asp Lys
90 95 100
ctt ctt gcc cgc gtg ggc gct tcc gga atc gcc gat cga cgc gtc ggc 451
Leu Leu Ala Arg Val Gly Ala Ser Gly Ile Ala Asp Arg Arg Val Gly
105 110 115
gag ctc tcc ggc ggg cag cag cag ctc gtc cgc caa gcc cag gcc ctt 499
Glu Leu Ser Gly Gly Gln Gln Gln Leu Val Arg Gln Ala Gln Ala Leu
120 125 130
gcc acg cgc ccg caa tta ttg ctt gcc gac gaa ccc ctc ctc agc ctt 547
Ala Thr Arg Pro Gln Leu Leu Leu Ala Asp Glu Pro Leu Leu Ser Leu
135 140 145
gac ccc ggc gtc gcg cag cgc acg gtg tcc cta ttt ggt gaa ttg aag 595
Asp Pro Gly Val Ala Gln Arg Thr Val Ser Leu Phe Gly Glu Leu Lys
150 155 160 165
gcc gaa ggc gtc ggc gtt gtt gtg gtc acc cac gat gtc aat cca cta 643
Ala Glu Gly Val Gly Val Val Val Val Thr His Asp Val Asn Pro Leu
170 175 180
atg ggc ctg gta gat cgc att ttg tac ctc gcc ccc aac ggc cac acc 691
Met Gly Leu Val Asp Arg Ile Leu Tyr Leu Ala Pro Asn Gly His Thr
185 190 195
atc ggc acg gtt ggc gat gtc atg cag tcc gaa aaa ctc agc gaa ctc 739
Ile Gly Thr Val Gly Asp Val Met Gln Ser Glu Lys Leu Ser Glu Leu
200 205 210
tac aac gca ccc gtc acg gtg gct cgc atc aac gac aga atc gtg gtg 787
Tyr Asn Ala Pro Val Thr Val Ala Arg Ile Asn Asp Arg Ile Val Val
215 220 225
gtt taagtggatc tatccacctg gct 813
Val
230
<210> 472
<211> 230
<212> PRT
<213> Corynebacterium glutamicum
<400> 472
Met Leu Leu Thr Phe Asn Asp Ala Ala Val Asp Pro Leu Trp Arg Gly
1 5 10 15
Leu Asn Leu Glu Leu Arg Gln Gly Glu Phe Leu Ala Val Leu Gly Pro
20 25 30
Asn Gly Val Gly Lys Ser Thr Leu Ile Gly Thr Ile Leu Gly Thr Arg
35 40 45
Lys Leu Thr His Gly Ser Val Lys Thr Asp Ala Arg Val Gly Tyr Ile
50 55 60
Pro Gln Gln Arg Ile Phe Asp Val Pro Leu Arg Ala Arg Asp Met Val
65 70 75 80
Ser Leu Ser Ala Ala His Gly Val Val Ser Lys Arg Gly Pro Ala Lys
85 90 95
Gly Asp Val Asp Lys Leu Leu Ala Arg Val Gly Ala Ser Gly Ile Ala
100 105 110
Asp Arg Arg Val Gly Glu Leu Ser Gly Gly Gln Gln Gln Leu Val Arg
115 120 125
Gln Ala Gln Ala Leu Ala Thr Arg Pro Gln Leu Leu Leu Ala Asp Glu
130 135 140
Pro Leu Leu Ser Leu Asp Pro Gly Val Ala Gln Arg Thr Val Ser Leu
145 150 155 160
Phe Gly Glu Leu Lys Ala Glu Gly Val Gly Val Val Val Val Thr His
165 170 175
Asp Val Asn Pro Leu Met Gly Leu Val Asp Arg Ile Leu Tyr Leu Ala
180 185 190
Pro Asn Gly His Thr Ile Gly Thr Val Gly Asp Val Met Gln Ser Glu
195 200 205
Lys Leu Ser Glu Leu Tyr Asn Ala Pro Val Thr Val Ala Arg Ile Asn
210 215 220
Asp Arg Ile Val Val Val
225 230
<210> 473
<211> 433
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(433)
<223> RXA00524
<400> 473
tcctcggcac ccgctacccc gtcggagttg tcaccggcgc attcggcgcc ccattcctta 60
tctatttact cattcgttcc aaccgcgcgg gagtaaccct gtg acc acc aac cat 115
Val Thr Thr Asn His
1 5
caa cta tcc gcc gaa gaa att tcc ctg gcg tac ggc gag cgc acc atc 163
Gln Leu Ser Ala Glu Glu Ile Ser Leu Ala Tyr Gly Glu Arg Thr Ile
10 15 20
atc gat tcg ctc agc gtc gac atc gtc ccc ggc aaa atc acc tcc atc 211
Ile Asp Ser Leu Ser Val Asp Ile Val Pro Gly Lys Ile Thr Ser Ile
25 30 35
gtc ggc ccc aac gga tgc ggc aaa tca acg ctg ctg cgc gcc ttt gcg 259
Val Gly Pro Asn Gly Cys Gly Lys Ser Thr Leu Leu Arg Ala Phe Ala
40 45 50
cgc ctc ctt aaa cct agc gcc ggg caa gcg ctt atc gac gcc cac ccc 307
Arg Leu Leu Lys Pro Ser Ala Gly Gln Ala Leu Ile Asp Ala His Pro
55 60 65
ctt cct tca ctg cca ggc aaa gaa cta gct cgc atg ctc ggg ctg tta 355
Leu Pro Ser Leu Pro Gly Lys Glu Leu Ala Arg Met Leu Gly Leu Leu
70 75 80 85
ccg caa tcc ccc acc gga cct gaa ggc atc gtc gtc gcc gac ctc gtg 403
Pro Gln Ser Pro Thr Gly Pro Glu Gly Ile Val Val Ala Asp Leu Val
90 95 100
ggc cgc ggc cgc cac ccc cac caa gga ctc 433
Gly Arg Gly Arg His Pro His Gln Gly Leu
105 110
<210> 474
<211> 111
<212> PRT
<213> Corynebacterium glutamicum
<400> 474
Val Thr Thr Asn His Gln Leu Ser Ala Glu Glu Ile Ser Leu Ala Tyr
1 5 10 15
Gly Glu Arg Thr Ile Ile Asp Ser Leu Ser Val Asp Ile Val Pro Gly
20 25 30
Lys Ile Thr Ser Ile Val Gly Pro Asn Gly Cys Gly Lys Ser Thr Leu
35 40 45
Leu Arg Ala Phe Ala Arg Leu Leu Lys Pro Ser Ala Gly Gln Ala Leu
50 55 60
Ile Asp Ala His Pro Leu Pro Ser Leu Pro Gly Lys Glu Leu Ala Arg
65 70 75 80
Met Leu Gly Leu Leu Pro Gln Ser Pro Thr Gly Pro Glu Gly Ile Val
85 90 95
Val Ala Asp Leu Val Gly Arg Gly Arg His Pro His Gln Gly Leu
100 105 110
<210> 475
<211> 900
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(877)
<223> RXA01823
<400> 475
gcaacacgtt gatactgagc tgcacacgcc cgttggcctg gtgaccagtt tgctgggcgg 60
ggtgtatttg atgtggcttt tgagccgaaa ggaggcataa atg ctg caa gcg cat 115
Met Leu Gln Ala His
1 5
gat ctc acg ctg agt tac ggc ggg cga aat att gta gaa ggg ctc agt 163
Asp Leu Thr Leu Ser Tyr Gly Gly Arg Asn Ile Val Glu Gly Leu Ser
10 15 20
ctg gac ctt ccg gaa aga ggc ctc agc atc atc att ggc ccc aac gga 211
Leu Asp Leu Pro Glu Arg Gly Leu Ser Ile Ile Ile Gly Pro Asn Gly
25 30 35
tgc ggg aaa tca acc gtt ttg aaa gcg ttg ggc aga ctg ctg aaa cca 259
Cys Gly Lys Ser Thr Val Leu Lys Ala Leu Gly Arg Leu Leu Lys Pro
40 45 50
caa ttg ggg aag atc acg cta ggt ggg cga gat att tcc agc atg ggc 307
Gln Leu Gly Lys Ile Thr Leu Gly Gly Arg Asp Ile Ser Ser Met Gly
55 60 65
acc aag cat gtg gcg aaa cac atc ggg gtg ctt ccg caa ccc cca tat 355
Thr Lys His Val Ala Lys His Ile Gly Val Leu Pro Gln Pro Pro Tyr
70 75 80 85
gcg ccc gat ggg gtg agc gtc acg gag ctg gtc agc cgc ggg cgg tat 403
Ala Pro Asp Gly Val Ser Val Thr Glu Leu Val Ser Arg Gly Arg Tyr
90 95 100
ccg cac caa cat ctg ctg tcg caa tgg tcg aaa gac gat gaa gcc att 451
Pro His Gln His Leu Leu Ser Gln Trp Ser Lys Asp Asp Glu Ala Ile
105 110 115
gtg gcg cgc tcg ctg gcg gaa gtc ggc atg cac acc cat gct gag cat 499
Val Ala Arg Ser Leu Ala Glu Val Gly Met His Thr His Ala Glu His
120 125 130
tta gtg tcg gaa ctt tca ggc ggc cag cgc caa cgg gcg tgg atc gcc 547
Leu Val Ser Glu Leu Ser Gly Gly Gln Arg Gln Arg Ala Trp Ile Ala
135 140 145
atg gcg ctc gct cag gaa aca gac att ttg ctt ctc gac gag ccc acc 595
Met Ala Leu Ala Gln Glu Thr Asp Ile Leu Leu Leu Asp Glu Pro Thr
150 155 160 165
acg ttc ctc gac gta gcc cac caa ata tcc gtc ctc gat tta tgc tcc 643
Thr Phe Leu Asp Val Ala His Gln Ile Ser Val Leu Asp Leu Cys Ser
170 175 180
gac ctg cac caa cgt ggt cgc acc ctg gcc att gtt cta cac gat ctg 691
Asp Leu His Gln Arg Gly Arg Thr Leu Ala Ile Val Leu His Asp Leu
185 190 195
aac atg gct gca cgg tat gcc acc cac atc atc gcc atg cgg gac ggc 739
Asn Met Ala Ala Arg Tyr Ala Thr His Ile Ile Ala Met Arg Asp Gly
200 205 210
acc atc atc gac caa gga aaa ccc gaa gaa ata ctc act aaa gcg ctg 787
Thr Ile Ile Asp Gln Gly Lys Pro Glu Glu Ile Leu Thr Lys Ala Leu
215 220 225
ctc aaa gaa gtt ttt gac ctc gac gca ctc atc ctc aaa gac ccc aac 835
Leu Lys Glu Val Phe Asp Leu Asp Ala Leu Ile Leu Lys Asp Pro Asn
230 235 240 245
aac ggc cga cca ctc atc gtg ccc aca gac agg aga aac tca 877
Asn Gly Arg Pro Leu Ile Val Pro Thr Asp Arg Arg Asn Ser
250 255
tgaaagaaac cgacaaccta ctg 900
<210> 476
<211> 259
<212> PRT
<213> Corynebacterium glutamicum
<400> 476
Met Leu Gln Ala His Asp Leu Thr Leu Ser Tyr Gly Gly Arg Asn Ile
1 5 10 15
Val Glu Gly Leu Ser Leu Asp Leu Pro Glu Arg Gly Leu Ser Ile Ile
20 25 30
Ile Gly Pro Asn Gly Cys Gly Lys Ser Thr Val Leu Lys Ala Leu Gly
35 40 45
Arg Leu Leu Lys Pro Gln Leu Gly Lys Ile Thr Leu Gly Gly Arg Asp
50 55 60
Ile Ser Ser Met Gly Thr Lys His Val Ala Lys His Ile Gly Val Leu
65 70 75 80
Pro Gln Pro Pro Tyr Ala Pro Asp Gly Val Ser Val Thr Glu Leu Val
85 90 95
Ser Arg Gly Arg Tyr Pro His Gln His Leu Leu Ser Gln Trp Ser Lys
100 105 110
Asp Asp Glu Ala Ile Val Ala Arg Ser Leu Ala Glu Val Gly Met His
115 120 125
Thr His Ala Glu His Leu Val Ser Glu Leu Ser Gly Gly Gln Arg Gln
130 135 140
Arg Ala Trp Ile Ala Met Ala Leu Ala Gln Glu Thr Asp Ile Leu Leu
145 150 155 160
Leu Asp Glu Pro Thr Thr Phe Leu Asp Val Ala His Gln Ile Ser Val
165 170 175
Leu Asp Leu Cys Ser Asp Leu His Gln Arg Gly Arg Thr Leu Ala Ile
180 185 190
Val Leu His Asp Leu Asn Met Ala Ala Arg Tyr Ala Thr His Ile Ile
195 200 205
Ala Met Arg Asp Gly Thr Ile Ile Asp Gln Gly Lys Pro Glu Glu Ile
210 215 220
Leu Thr Lys Ala Leu Leu Lys Glu Val Phe Asp Leu Asp Ala Leu Ile
225 230 235 240
Leu Lys Asp Pro Asn Asn Gly Arg Pro Leu Ile Val Pro Thr Asp Arg
245 250 255
Arg Asn Ser
<210> 477
<211> 906
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(883)
<223> RXA02767
<400> 477
gggaaaacgt ttcctcgccg cccacagaat cataaaaatt ttctgaggtt gtcatgggta 60
ccagtctaag ccctggcctt acgccagtaa ggtgttaccc atg cgc gaa cta gca 115
Met Arg Glu Leu Ala
1 5
ctc aac atg gcc ggc gtc acc gtg cgg cgc ggc gag aaa ttg ctt ctc 163
Leu Asn Met Ala Gly Val Thr Val Arg Arg Gly Glu Lys Leu Leu Leu
10 15 20
gac gat atc tcc ctc tca att ccg caa ggg tcg cac tgg gcc gta ctt 211
Asp Asp Ile Ser Leu Ser Ile Pro Gln Gly Ser His Trp Ala Val Leu
25 30 35
ggt cca aat ggc gcc ggt aaa acc acc atg ctg aag atc gca gcc acc 259
Gly Pro Asn Gly Ala Gly Lys Thr Thr Met Leu Lys Ile Ala Ala Thr
40 45 50
ttg ctg tac cca tcg gaa ggc acc gtg gac atc ctg ggg cat cgc ttt 307
Leu Leu Tyr Pro Ser Glu Gly Thr Val Asp Ile Leu Gly His Arg Phe
55 60 65
ggt cgg gtg gat act cgt gag ctg cgg aaa aca atc ggc ctg gtg gac 355
Gly Arg Val Asp Thr Arg Glu Leu Arg Lys Thr Ile Gly Leu Val Asp
70 75 80 85
ccg aag caa aga ttt acc aac ctg ccg gcc cac gaa att gtg ctg tcg 403
Pro Lys Gln Arg Phe Thr Asn Leu Pro Ala His Glu Ile Val Leu Ser
90 95 100
ggg tta acc gcc tcc aac ggg ttg ttg cca cgg tgg tcg gct tcg gct 451
Gly Leu Thr Ala Ser Asn Gly Leu Leu Pro Arg Trp Ser Ala Ser Ala
105 110 115
tcg gag ttg gag cgg tgc gct ttg atg ttg gag ttg gtg ggc atg aca 499
Ser Glu Leu Glu Arg Cys Ala Leu Met Leu Glu Leu Val Gly Met Thr
120 125 130
gcg cgt gcc gat cgt tac tgg gcc gat atg agc cag ggc gaa aaa gcc 547
Ala Arg Ala Asp Arg Tyr Trp Ala Asp Met Ser Gln Gly Glu Lys Ala
135 140 145
cgc acc ctg att gct cgt gcg ctg att atc tca ccg acc cta ctg ctg 595
Arg Thr Leu Ile Ala Arg Ala Leu Ile Ile Ser Pro Thr Leu Leu Leu
150 155 160 165
ctt gat gaa ccc acc acc ggc ctt gac ctg ccc gga cgt gaa act ttg 643
Leu Asp Glu Pro Thr Thr Gly Leu Asp Leu Pro Gly Arg Glu Thr Leu
170 175 180
ctc agt gtg att gat ggt ttg cga gcc gct ctt cct ggt ctg acg aca 691
Leu Ser Val Ile Asp Gly Leu Arg Ala Ala Leu Pro Gly Leu Thr Thr
185 190 195
gtg atg atc acc cac cac gtc gaa gag atc gcc gcc tcc acg aca gat 739
Val Met Ile Thr His His Val Glu Glu Ile Ala Ala Ser Thr Thr Asp
200 205 210
atc ctc atg atc aag gac gcc cgc ata ctg gct tcg ggg act gtt tca 787
Ile Leu Met Ile Lys Asp Ala Arg Ile Leu Ala Ser Gly Thr Val Ser
215 220 225
gaa gtg atg act cct gaa aat ttg ggc gcg ctg tat gac atg tcg gtg 835
Glu Val Met Thr Pro Glu Asn Leu Gly Ala Leu Tyr Asp Met Ser Val
230 235 240 245
tcg ttg gaa act gtg cgc agc cgg tgg ttc gcg ttc gat gct ctg cat 883
Ser Leu Glu Thr Val Arg Ser Arg Trp Phe Ala Phe Asp Ala Leu His
250 255 260
taaaaggggc tagttttaca caa 906
<210> 478
<211> 261
<212> PRT
<213> Corynebacterium glutamicum
<400> 478
Met Arg Glu Leu Ala Leu Asn Met Ala Gly Val Thr Val Arg Arg Gly
1 5 10 15
Glu Lys Leu Leu Leu Asp Asp Ile Ser Leu Ser Ile Pro Gln Gly Ser
20 25 30
His Trp Ala Val Leu Gly Pro Asn Gly Ala Gly Lys Thr Thr Met Leu
35 40 45
Lys Ile Ala Ala Thr Leu Leu Tyr Pro Ser Glu Gly Thr Val Asp Ile
50 55 60
Leu Gly His Arg Phe Gly Arg Val Asp Thr Arg Glu Leu Arg Lys Thr
65 70 75 80
Ile Gly Leu Val Asp Pro Lys Gln Arg Phe Thr Asn Leu Pro Ala His
85 90 95
Glu Ile Val Leu Ser Gly Leu Thr Ala Ser Asn Gly Leu Leu Pro Arg
100 105 110
Trp Ser Ala Ser Ala Ser Glu Leu Glu Arg Cys Ala Leu Met Leu Glu
115 120 125
Leu Val Gly Met Thr Ala Arg Ala Asp Arg Tyr Trp Ala Asp Met Ser
130 135 140
Gln Gly Glu Lys Ala Arg Thr Leu Ile Ala Arg Ala Leu Ile Ile Ser
145 150 155 160
Pro Thr Leu Leu Leu Leu Asp Glu Pro Thr Thr Gly Leu Asp Leu Pro
165 170 175
Gly Arg Glu Thr Leu Leu Ser Val Ile Asp Gly Leu Arg Ala Ala Leu
180 185 190
Pro Gly Leu Thr Thr Val Met Ile Thr His His Val Glu Glu Ile Ala
195 200 205
Ala Ser Thr Thr Asp Ile Leu Met Ile Lys Asp Ala Arg Ile Leu Ala
210 215 220
Ser Gly Thr Val Ser Glu Val Met Thr Pro Glu Asn Leu Gly Ala Leu
225 230 235 240
Tyr Asp Met Ser Val Ser Leu Glu Thr Val Arg Ser Arg Trp Phe Ala
245 250 255
Phe Asp Ala Leu His
260
<210> 479
<211> 876
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(853)
<223> RXA02792
<400> 479
agaacaaagt gctgcccata ctcatgaact ttgccgaacc cccaaccccg ctggccgtcg 60
atggcctaga aaaaatcatc gactttgtgg aaacccaccc atg atc gag gcc aca 115
Met Ile Glu Ala Thr
1 5
cac cta cgc cac agt ttt ggc gac aac atc gtc atc gat gac gtc acc 163
His Leu Arg His Ser Phe Gly Asp Asn Ile Val Ile Asp Asp Val Thr
10 15 20
ctc cat cta cct gca cac ggc acc gtc agc ttg gtc ggc ccc aac ggc 211
Leu His Leu Pro Ala His Gly Thr Val Ser Leu Val Gly Pro Asn Gly
25 30 35
agt ggc aaa acc acc ctg ctg cgt gca cta tac gga gca ctg caa cca 259
Ser Gly Lys Thr Thr Leu Leu Arg Ala Leu Tyr Gly Ala Leu Gln Pro
40 45 50
aat gaa ggg cac atc cac gta gat ggc gtt cca cta ata agc ttg cac 307
Asn Glu Gly His Ile His Val Asp Gly Val Pro Leu Ile Ser Leu His
55 60 65
cgc aaa gac atc gca aaa acc atg gcc gta gtc atc caa gaa cat gac 355
Arg Lys Asp Ile Ala Lys Thr Met Ala Val Val Ile Gln Glu His Asp
70 75 80 85
tcc gac ctc ccc atg acc gtc gct gac ctg gtc tta cta ggc aga ctc 403
Ser Asp Leu Pro Met Thr Val Ala Asp Leu Val Leu Leu Gly Arg Leu
90 95 100
ccc cac caa aag atg ttt gcc ggc aac tct caa gct gat cag tta ctc 451
Pro His Gln Lys Met Phe Ala Gly Asn Ser Gln Ala Asp Gln Leu Leu
105 110 115
gtt aag gaa gca ctc acc cga gtc ggc gcc att cac ctg gcc gac cga 499
Val Lys Glu Ala Leu Thr Arg Val Gly Ala Ile His Leu Ala Asp Arg
120 125 130
caa ttc ggc gca ctt tca ggc ggt gaa cgc caa cgc gtc ctc atc gca 547
Gln Phe Gly Ala Leu Ser Gly Gly Glu Arg Gln Arg Val Leu Ile Ala
135 140 145
cga gca ctc gta caa aac gcc aca cac att ctg ctc gac gaa ccc acc 595
Arg Ala Leu Val Gln Asn Ala Thr His Ile Leu Leu Asp Glu Pro Thr
150 155 160 165
aac cac ctc gac atc cgc tac cag cac gaa gtc ctt cac ctc gtc cgc 643
Asn His Leu Asp Ile Arg Tyr Gln His Glu Val Leu His Leu Val Arg
170 175 180
gaa ctc agc tca agt tcc atc atc gtc ctc cac gac ctc aac ctc gca 691
Glu Leu Ser Ser Ser Ser Ile Ile Val Leu His Asp Leu Asn Leu Ala
185 190 195
ggt gcc tac agc gac cac atc atc ctc ctt gac caa gga cgt gtg gtt 739
Gly Ala Tyr Ser Asp His Ile Ile Leu Leu Asp Gln Gly Arg Val Val
200 205 210
act caa gga acg ccc tca gag gta ttg acc cca gag cat ttg gaa cct 787
Thr Gln Gly Thr Pro Ser Glu Val Leu Thr Pro Glu His Leu Glu Pro
215 220 225
gtg tat ggc gtt cgt gtt gag cgc ttt gac cta ggc gat gaa gtc cac 835
Val Tyr Gly Val Arg Val Glu Arg Phe Asp Leu Gly Asp Glu Val His
230 235 240 245
ctt cgg ttc aag cgt cac taggagtttt gttgaggagg tgg 876
Leu Arg Phe Lys Arg His
250
<210> 480
<211> 251
<212> PRT
<213> Corynebacterium glutamicum
<400> 480
Met Ile Glu Ala Thr His Leu Arg His Ser Phe Gly Asp Asn Ile Val
1 5 10 15
Ile Asp Asp Val Thr Leu His Leu Pro Ala His Gly Thr Val Ser Leu
20 25 30
Val Gly Pro Asn Gly Ser Gly Lys Thr Thr Leu Leu Arg Ala Leu Tyr
35 40 45
Gly Ala Leu Gln Pro Asn Glu Gly His Ile His Val Asp Gly Val Pro
50 55 60
Leu Ile Ser Leu His Arg Lys Asp Ile Ala Lys Thr Met Ala Val Val
65 70 75 80
Ile Gln Glu His Asp Ser Asp Leu Pro Met Thr Val Ala Asp Leu Val
85 90 95
Leu Leu Gly Arg Leu Pro His Gln Lys Met Phe Ala Gly Asn Ser Gln
100 105 110
Ala Asp Gln Leu Leu Val Lys Glu Ala Leu Thr Arg Val Gly Ala Ile
115 120 125
His Leu Ala Asp Arg Gln Phe Gly Ala Leu Ser Gly Gly Glu Arg Gln
130 135 140
Arg Val Leu Ile Ala Arg Ala Leu Val Gln Asn Ala Thr His Ile Leu
145 150 155 160
Leu Asp Glu Pro Thr Asn His Leu Asp Ile Arg Tyr Gln His Glu Val
165 170 175
Leu His Leu Val Arg Glu Leu Ser Ser Ser Ser Ile Ile Val Leu His
180 185 190
Asp Leu Asn Leu Ala Gly Ala Tyr Ser Asp His Ile Ile Leu Leu Asp
195 200 205
Gln Gly Arg Val Val Thr Gln Gly Thr Pro Ser Glu Val Leu Thr Pro
210 215 220
Glu His Leu Glu Pro Val Tyr Gly Val Arg Val Glu Arg Phe Asp Leu
225 230 235 240
Gly Asp Glu Val His Leu Arg Phe Lys Arg His
245 250
<210> 481
<211> 1161
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1138)
<223> RXN02929
<400> 481
caggtgggga cctcgcgtat cccagctggt ggaagaaatc gcagcgcagt tgaatcagct 60
tgcttcttct gaagctgtgc cggccgctgc ttaagttttc gtg ctg aag aga att 115
Val Leu Lys Arg Ile
1 5
ttc ctc aac ccc tgg gtg gct acc gcg ttg tcg gta gtc att ttg ggg 163
Phe Leu Asn Pro Trp Val Ala Thr Ala Leu Ser Val Val Ile Leu Gly
10 15 20
ttt gtg gtg ctg ttt tca ggt ttt agc ggt gtt att gat tta agc ccc 211
Phe Val Val Leu Phe Ser Gly Phe Ser Gly Val Ile Asp Leu Ser Pro
25 30 35
aca gca gtg att aga cat ttg agt ggg cag gac acg ctc acc cct cga 259
Thr Ala Val Ile Arg His Leu Ser Gly Gln Asp Thr Leu Thr Pro Arg
40 45 50
gat cag gcc atc ttc ttt gat atc cgg ctg cct cga att atc gct ggt 307
Asp Gln Ala Ile Phe Phe Asp Ile Arg Leu Pro Arg Ile Ile Ala Gly
55 60 65
gtc att gtc gga gca acg ctg gct att tct ggt gct tct tac caa gcg 355
Val Ile Val Gly Ala Thr Leu Ala Ile Ser Gly Ala Ser Tyr Gln Ala
70 75 80 85
gta ttt aga aac ccg ctg gct gat cct tat ttg ttg ggt gtg tcc gca 403
Val Phe Arg Asn Pro Leu Ala Asp Pro Tyr Leu Leu Gly Val Ser Ala
90 95 100
ggt tct ggc ctt ggt gtc acg gca gtg att gtt ggc ggt acc gtg ctg 451
Gly Ser Gly Leu Gly Val Thr Ala Val Ile Val Gly Gly Thr Val Leu
105 110 115
gga ttt tct gca ccg agc atc ggc gtg att ggt gca gca ttt gta ggt 499
Gly Phe Ser Ala Pro Ser Ile Gly Val Ile Gly Ala Ala Phe Val Gly
120 125 130
ggt gtt gcc gca gta ctt gcc acg ctg atg gtg agt cgg gga gta gga 547
Gly Val Ala Ala Val Leu Ala Thr Leu Met Val Ser Arg Gly Val Gly
135 140 145
cag gga tca tca acc acc gtg gtt att ttg gcg ggc gtg gcg gtt gct 595
Gln Gly Ser Ser Thr Thr Val Val Ile Leu Ala Gly Val Ala Val Ala
150 155 160 165
gct ttt gcc agt tcc atc cag acc tat att cag caa cga cac atc gat 643
Ala Phe Ala Ser Ser Ile Gln Thr Tyr Ile Gln Gln Arg His Ile Asp
170 175 180
acg gtg gcg cgc gta tat gtg tgg atg ttg ggc aac ctc aat gtc acc 691
Thr Val Ala Arg Val Tyr Val Trp Met Leu Gly Asn Leu Asn Val Thr
185 190 195
aac tgg atg tcg atc ttc atc gtg gct gtg gtg gcg gga cta tgc gcg 739
Asn Trp Met Ser Ile Phe Ile Val Ala Val Val Ala Gly Leu Cys Ala
200 205 210
gcc gtg atc atg tcc tgc gcc agg ttg tta gac gtg atg gct gtt ggt 787
Ala Val Ile Met Ser Cys Ala Arg Leu Leu Asp Val Met Ala Val Gly
215 220 225
gat gtg gaa gcc cgc aca ttg ggc gtc gat cca ggc ctc gta cgc att 835
Asp Val Glu Ala Arg Thr Leu Gly Val Asp Pro Gly Leu Val Arg Ile
230 235 240 245
ggc att gtc atc gtg gca acc ctt ggt aca gct gca gtg gta tcc att 883
Gly Ile Val Ile Val Ala Thr Leu Gly Thr Ala Ala Val Val Ser Ile
250 255 260
tcc ggt ctc atc ggg ttt gtg ggc atc att gtt ccg cac gcc ctg cgc 931
Ser Gly Leu Ile Gly Phe Val Gly Ile Ile Val Pro His Ala Leu Arg
265 270 275
cta att gtt ggc ccg ggg cat cgg att tta ctg cca ctg tct ttc gta 979
Leu Ile Val Gly Pro Gly His Arg Ile Leu Leu Pro Leu Ser Phe Val
280 285 290
tgg ggt gcc att ttc ctc gtg ttg gca gat acc gca ggg cga aca ttg 1027
Trp Gly Ala Ile Phe Leu Val Leu Ala Asp Thr Ala Gly Arg Thr Leu
295 300 305
atg gct cct cag gaa ctt ccc gtg ggt gtg gtg aca gct gca ctc ggc 1075
Met Ala Pro Gln Glu Leu Pro Val Gly Val Val Thr Ala Ala Leu Gly
310 315 320 325
gca ccg ttc ttc tta ttt att ttg cgc aga acc agc aga caa cga gtt 1123
Ala Pro Phe Phe Leu Phe Ile Leu Arg Arg Thr Ser Arg Gln Arg Val
330 335 340
cca aaa agg agt gct taagtggcga tcattgaatg cga 1161
Pro Lys Arg Ser Ala
345
<210> 482
<211> 346
<212> PRT
<213> Corynebacterium glutamicum
<400> 482
Val Leu Lys Arg Ile Phe Leu Asn Pro Trp Val Ala Thr Ala Leu Ser
1 5 10 15
Val Val Ile Leu Gly Phe Val Val Leu Phe Ser Gly Phe Ser Gly Val
20 25 30
Ile Asp Leu Ser Pro Thr Ala Val Ile Arg His Leu Ser Gly Gln Asp
35 40 45
Thr Leu Thr Pro Arg Asp Gln Ala Ile Phe Phe Asp Ile Arg Leu Pro
50 55 60
Arg Ile Ile Ala Gly Val Ile Val Gly Ala Thr Leu Ala Ile Ser Gly
65 70 75 80
Ala Ser Tyr Gln Ala Val Phe Arg Asn Pro Leu Ala Asp Pro Tyr Leu
85 90 95
Leu Gly Val Ser Ala Gly Ser Gly Leu Gly Val Thr Ala Val Ile Val
100 105 110
Gly Gly Thr Val Leu Gly Phe Ser Ala Pro Ser Ile Gly Val Ile Gly
115 120 125
Ala Ala Phe Val Gly Gly Val Ala Ala Val Leu Ala Thr Leu Met Val
130 135 140
Ser Arg Gly Val Gly Gln Gly Ser Ser Thr Thr Val Val Ile Leu Ala
145 150 155 160
Gly Val Ala Val Ala Ala Phe Ala Ser Ser Ile Gln Thr Tyr Ile Gln
165 170 175
Gln Arg His Ile Asp Thr Val Ala Arg Val Tyr Val Trp Met Leu Gly
180 185 190
Asn Leu Asn Val Thr Asn Trp Met Ser Ile Phe Ile Val Ala Val Val
195 200 205
Ala Gly Leu Cys Ala Ala Val Ile Met Ser Cys Ala Arg Leu Leu Asp
210 215 220
Val Met Ala Val Gly Asp Val Glu Ala Arg Thr Leu Gly Val Asp Pro
225 230 235 240
Gly Leu Val Arg Ile Gly Ile Val Ile Val Ala Thr Leu Gly Thr Ala
245 250 255
Ala Val Val Ser Ile Ser Gly Leu Ile Gly Phe Val Gly Ile Ile Val
260 265 270
Pro His Ala Leu Arg Leu Ile Val Gly Pro Gly His Arg Ile Leu Leu
275 280 285
Pro Leu Ser Phe Val Trp Gly Ala Ile Phe Leu Val Leu Ala Asp Thr
290 295 300
Ala Gly Arg Thr Leu Met Ala Pro Gln Glu Leu Pro Val Gly Val Val
305 310 315 320
Thr Ala Ala Leu Gly Ala Pro Phe Phe Leu Phe Ile Leu Arg Arg Thr
325 330 335
Ser Arg Gln Arg Val Pro Lys Arg Ser Ala
340 345
<210> 483
<211> 1095
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1072)
<223> FRXA01235
<400> 483
ttctgaagct gtgccggccg ctgcttaagt tttcgtgctg aagagaattt tcctcaaccc 60
ctgggtggct accgcgttgt cggtagtcat tttggggttt gtg gtg ctg ttt tca 115
Val Val Leu Phe Ser
1 5
ggt ttt agc ggt gtt att gat tta agc ccc aca gca gtg att aga cat 163
Gly Phe Ser Gly Val Ile Asp Leu Ser Pro Thr Ala Val Ile Arg His
10 15 20
ttg agt ggg cag gac acg ctc acc cct cga gat cag gcc atc ttc ttt 211
Leu Ser Gly Gln Asp Thr Leu Thr Pro Arg Asp Gln Ala Ile Phe Phe
25 30 35
gat atc cgg ctg cct cga att atc gct ggt gtc att gtc gga gca acg 259
Asp Ile Arg Leu Pro Arg Ile Ile Ala Gly Val Ile Val Gly Ala Thr
40 45 50
ctg gct att tct ggt gct gct tac caa gcg gta ttt aga aac ccg ctg 307
Leu Ala Ile Ser Gly Ala Ala Tyr Gln Ala Val Phe Arg Asn Pro Leu
55 60 65
gct gat cct tat ttg ttg ggt gtg tcc gca ggt tct ggc ctt ggt gtc 355
Ala Asp Pro Tyr Leu Leu Gly Val Ser Ala Gly Ser Gly Leu Gly Val
70 75 80 85
acg gca gtg att gtt ggc ggt acc gtg ctg gga ttt tct gca ccg agc 403
Thr Ala Val Ile Val Gly Gly Thr Val Leu Gly Phe Ser Ala Pro Ser
90 95 100
atc ggc gtg att ggt gca gca ttt gta ggt ggt gtt gcc gca gta ctt 451
Ile Gly Val Ile Gly Ala Ala Phe Val Gly Gly Val Ala Ala Val Leu
105 110 115
gcc acg ctg atg gtg agt cgg gga gta gga cag gga tca tca acc acc 499
Ala Thr Leu Met Val Ser Arg Gly Val Gly Gln Gly Ser Ser Thr Thr
120 125 130
gtg gtt att ttg gcg ggc gtg gcg gtt gct gct ttt gcc agt tcc atc 547
Val Val Ile Leu Ala Gly Val Ala Val Ala Ala Phe Ala Ser Ser Ile
135 140 145
cag acc tat att cag caa cga cac atc gat acg gtg gcg cgc gta tat 595
Gln Thr Tyr Ile Gln Gln Arg His Ile Asp Thr Val Ala Arg Val Tyr
150 155 160 165
gtg tgg atg ttg ggc aac ctc aat gtc acc aac tgg atg tcg atc ttc 643
Val Trp Met Leu Gly Asn Leu Asn Val Thr Asn Trp Met Ser Ile Phe
170 175 180
atc gtg gct gtg gtg gcg gga cta tgc gcg gcc gtg atc atg tcc tgc 691
Ile Val Ala Val Val Ala Gly Leu Cys Ala Ala Val Ile Met Ser Cys
185 190 195
gcc agg ttg tta gac gtg atg gct gtt ggt gat gtg gaa gcc cgc aca 739
Ala Arg Leu Leu Asp Val Met Ala Val Gly Asp Val Glu Ala Arg Thr
200 205 210
ttg ggc gtc gat cca ggc ctc gta cgc att ggc att gtc atc gtg gca 787
Leu Gly Val Asp Pro Gly Leu Val Arg Ile Gly Ile Val Ile Val Ala
215 220 225
acc ctt ggt aca gct gca gtg gta tcc att tcc ggt ctc atc ggg ttt 835
Thr Leu Gly Thr Ala Ala Val Val Ser Ile Ser Gly Leu Ile Gly Phe
230 235 240 245
gtg ggc atc att gtt ccg cac gcc ctg cgc cta att gtt ggc ccg ggg 883
Val Gly Ile Ile Val Pro His Ala Leu Arg Leu Ile Val Gly Pro Gly
250 255 260
cat cgg att tta ctg cca ctg tct ttc gta tgg ggt gcc att ttc ctc 931
His Arg Ile Leu Leu Pro Leu Ser Phe Val Trp Gly Ala Ile Phe Leu
265 270 275
gtg ttg gca gat acc gca ggg cga aca ttg atg gct cct cag gaa ctt 979
Val Leu Ala Asp Thr Ala Gly Arg Thr Leu Met Ala Pro Gln Glu Leu
280 285 290
ccc gtg ggt gtg gtg aca gct gca ctc ggc gca ccg ttc ttc tta ttt 1027
Pro Val Gly Val Val Thr Ala Ala Leu Gly Ala Pro Phe Phe Leu Phe
295 300 305
att ttg cgc aga acc agc aga caa cga gtt cca aaa agg agt gct 1072
Ile Leu Arg Arg Thr Ser Arg Gln Arg Val Pro Lys Arg Ser Ala
310 315 320
taagtggcga tcattgaatg cga 1095
<210> 484
<211> 324
<212> PRT
<213> Corynebacterium glutamicum
<400> 484
Val Val Leu Phe Ser Gly Phe Ser Gly Val Ile Asp Leu Ser Pro Thr
1 5 10 15
Ala Val Ile Arg His Leu Ser Gly Gln Asp Thr Leu Thr Pro Arg Asp
20 25 30
Gln Ala Ile Phe Phe Asp Ile Arg Leu Pro Arg Ile Ile Ala Gly Val
35 40 45
Ile Val Gly Ala Thr Leu Ala Ile Ser Gly Ala Ala Tyr Gln Ala Val
50 55 60
Phe Arg Asn Pro Leu Ala Asp Pro Tyr Leu Leu Gly Val Ser Ala Gly
65 70 75 80
Ser Gly Leu Gly Val Thr Ala Val Ile Val Gly Gly Thr Val Leu Gly
85 90 95
Phe Ser Ala Pro Ser Ile Gly Val Ile Gly Ala Ala Phe Val Gly Gly
100 105 110
Val Ala Ala Val Leu Ala Thr Leu Met Val Ser Arg Gly Val Gly Gln
115 120 125
Gly Ser Ser Thr Thr Val Val Ile Leu Ala Gly Val Ala Val Ala Ala
130 135 140
Phe Ala Ser Ser Ile Gln Thr Tyr Ile Gln Gln Arg His Ile Asp Thr
145 150 155 160
Val Ala Arg Val Tyr Val Trp Met Leu Gly Asn Leu Asn Val Thr Asn
165 170 175
Trp Met Ser Ile Phe Ile Val Ala Val Val Ala Gly Leu Cys Ala Ala
180 185 190
Val Ile Met Ser Cys Ala Arg Leu Leu Asp Val Met Ala Val Gly Asp
195 200 205
Val Glu Ala Arg Thr Leu Gly Val Asp Pro Gly Leu Val Arg Ile Gly
210 215 220
Ile Val Ile Val Ala Thr Leu Gly Thr Ala Ala Val Val Ser Ile Ser
225 230 235 240
Gly Leu Ile Gly Phe Val Gly Ile Ile Val Pro His Ala Leu Arg Leu
245 250 255
Ile Val Gly Pro Gly His Arg Ile Leu Leu Pro Leu Ser Phe Val Trp
260 265 270
Gly Ala Ile Phe Leu Val Leu Ala Asp Thr Ala Gly Arg Thr Leu Met
275 280 285
Ala Pro Gln Glu Leu Pro Val Gly Val Val Thr Ala Ala Leu Gly Ala
290 295 300
Pro Phe Phe Leu Phe Ile Leu Arg Arg Thr Ser Arg Gln Arg Val Pro
305 310 315 320
Lys Arg Ser Ala
<210> 485
<211> 1197
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1174)
<223> RXN02794
<400> 485
gcgcccactc atcggcgagc ttcaggagat gaggttgatg ctccattgat aatttctttc 60
gctaatagtc aaatgatcat ttgagtgtta gtgttttctc atg ctt ctt tcc gcc 115
Met Leu Leu Ser Ala
1 5
cgc aca cac acg agt ttc caa gaa ctt gga ctc aat gct agt cgg cgc 163
Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu Asn Ala Ser Arg Arg
10 15 20
aaa gca atc aac tgg aca ctg gca ctc act gtg gtg cta att gcc tcc 211
Lys Ala Ile Asn Trp Thr Leu Ala Leu Thr Val Val Leu Ile Ala Ser
25 30 35
atg ttt gtt ggc gtg ctc atc ggt gca tcc ggg acc tca gtg ttt tcc 259
Met Phe Val Gly Val Leu Ile Gly Ala Ser Gly Thr Ser Val Phe Ser
40 45 50
acg tgg acc gta att agc cac cat ctt ttt ggc act gag cta ggt ggc 307
Thr Trp Thr Val Ile Ser His His Leu Phe Gly Thr Glu Leu Gly Gly
55 60 65
tcc gac act gcc gac gcc atc att tgg tac atc cgc acc cca cgc gtc 355
Ser Asp Thr Ala Asp Ala Ile Ile Trp Tyr Ile Arg Thr Pro Arg Val
70 75 80 85
ttg ctc gct gcc att gtg ggc gca ggc ctt gcc ctg gca ggt gcc atc 403
Leu Leu Ala Ala Ile Val Gly Ala Gly Leu Ala Leu Ala Gly Ala Ile
90 95 100
atg caa gta ctg gtc cga aac atg ctg gca gac ccc tat atc ctc ggg 451
Met Gln Val Leu Val Arg Asn Met Leu Ala Asp Pro Tyr Ile Leu Gly
105 110 115
gtg aac tca ggt gcc agt tgc ggt gcg gcc gct gcc tta ctg ttc gga 499
Val Asn Ser Gly Ala Ser Cys Gly Ala Ala Ala Ala Leu Leu Phe Gly
120 125 130
gtg ggc gct gga ttt ggc gat tac gcc ctc caa ggc agc gcg ttt ctc 547
Val Gly Ala Gly Phe Gly Asp Tyr Ala Leu Gln Gly Ser Ala Phe Leu
135 140 145
ggc gca atg gca gct tcc gga ttg atc ttc ttc gtg gcg cgc gca gcg 595
Gly Ala Met Ala Ala Ser Gly Leu Ile Phe Phe Val Ala Arg Ala Ala
150 155 160 165
ggg cgc atc tcc tcg acc cgc ttg ttg atg tcc ggc gta gcg atc gga 643
Gly Arg Ile Ser Ser Thr Arg Leu Leu Met Ser Gly Val Ala Ile Gly
170 175 180
tac atg ctc tct gcg gca aca agc ttt ctc atc ttc tcc tcc gac tcc 691
Tyr Met Leu Ser Ala Ala Thr Ser Phe Leu Ile Phe Ser Ser Asp Ser
185 190 195
gcc gaa ggc agc cgc tcc gtg ttg ttc tgg ctg ctt gga tcc tta gga 739
Ala Glu Gly Ser Arg Ser Val Leu Phe Trp Leu Leu Gly Ser Leu Gly
200 205 210
ctt gcc gca tgg aat ggg ccg atg gcg atc atc ttc ctc atc gtg ggc 787
Leu Ala Ala Trp Asn Gly Pro Met Ala Ile Ile Phe Leu Ile Val Gly
215 220 225
att gcc ctg gcg ttg ctc atg gtg ttg ggt ccg caa ttg gat gcc tta 835
Ile Ala Leu Ala Leu Leu Met Val Leu Gly Pro Gln Leu Asp Ala Leu
230 235 240 245
aac tcc ggc gat gaa acc gca ctt acc ttg gga gta tcc cct gat cgc 883
Asn Ser Gly Asp Glu Thr Ala Leu Thr Leu Gly Val Ser Pro Asp Arg
250 255 260
ctc cgc att ctc ctc ctg gtg atc acc tgc ctg ctg gtg gga tcc atg 931
Leu Arg Ile Leu Leu Leu Val Ile Thr Cys Leu Leu Val Gly Ser Met
265 270 275
gtt gcc atg gcc ggc agc atc gga ttc atc ggc ctt gtc atc ccc cac 979
Val Ala Met Ala Gly Ser Ile Gly Phe Ile Gly Leu Val Ile Pro His
280 285 290
ctg gcc agg cgt ttt gtt agt gga aaa cac cga ctc atg ctg cct gta 1027
Leu Ala Arg Arg Phe Val Ser Gly Lys His Arg Leu Met Leu Pro Val
295 300 305
tcc gcg ttg atg ggc gca att ttg ctc atc tgg gct gat atc gcc gcc 1075
Ser Ala Leu Met Gly Ala Ile Leu Leu Ile Trp Ala Asp Ile Ala Ala
310 315 320 325
cgc acc ctg ctt gcg ccc caa gag att ccc atc ggc atc atc acc gca 1123
Arg Thr Leu Leu Ala Pro Gln Glu Ile Pro Ile Gly Ile Ile Thr Ala
330 335 340
ctc atc gga gca ccc ttc ctc ctg att ctg gtt cgc cgg atg cac acc 1171
Leu Ile Gly Ala Pro Phe Leu Leu Ile Leu Val Arg Arg Met His Thr
345 350 355
tac tgatttttaa ggaattatgc gta 1197
Tyr
<210> 486
<211> 358
<212> PRT
<213> Corynebacterium glutamicum
<400> 486
Met Leu Leu Ser Ala Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu
1 5 10 15
Asn Ala Ser Arg Arg Lys Ala Ile Asn Trp Thr Leu Ala Leu Thr Val
20 25 30
Val Leu Ile Ala Ser Met Phe Val Gly Val Leu Ile Gly Ala Ser Gly
35 40 45
Thr Ser Val Phe Ser Thr Trp Thr Val Ile Ser His His Leu Phe Gly
50 55 60
Thr Glu Leu Gly Gly Ser Asp Thr Ala Asp Ala Ile Ile Trp Tyr Ile
65 70 75 80
Arg Thr Pro Arg Val Leu Leu Ala Ala Ile Val Gly Ala Gly Leu Ala
85 90 95
Leu Ala Gly Ala Ile Met Gln Val Leu Val Arg Asn Met Leu Ala Asp
100 105 110
Pro Tyr Ile Leu Gly Val Asn Ser Gly Ala Ser Cys Gly Ala Ala Ala
115 120 125
Ala Leu Leu Phe Gly Val Gly Ala Gly Phe Gly Asp Tyr Ala Leu Gln
130 135 140
Gly Ser Ala Phe Leu Gly Ala Met Ala Ala Ser Gly Leu Ile Phe Phe
145 150 155 160
Val Ala Arg Ala Ala Gly Arg Ile Ser Ser Thr Arg Leu Leu Met Ser
165 170 175
Gly Val Ala Ile Gly Tyr Met Leu Ser Ala Ala Thr Ser Phe Leu Ile
180 185 190
Phe Ser Ser Asp Ser Ala Glu Gly Ser Arg Ser Val Leu Phe Trp Leu
195 200 205
Leu Gly Ser Leu Gly Leu Ala Ala Trp Asn Gly Pro Met Ala Ile Ile
210 215 220
Phe Leu Ile Val Gly Ile Ala Leu Ala Leu Leu Met Val Leu Gly Pro
225 230 235 240
Gln Leu Asp Ala Leu Asn Ser Gly Asp Glu Thr Ala Leu Thr Leu Gly
245 250 255
Val Ser Pro Asp Arg Leu Arg Ile Leu Leu Leu Val Ile Thr Cys Leu
260 265 270
Leu Val Gly Ser Met Val Ala Met Ala Gly Ser Ile Gly Phe Ile Gly
275 280 285
Leu Val Ile Pro His Leu Ala Arg Arg Phe Val Ser Gly Lys His Arg
290 295 300
Leu Met Leu Pro Val Ser Ala Leu Met Gly Ala Ile Leu Leu Ile Trp
305 310 315 320
Ala Asp Ile Ala Ala Arg Thr Leu Leu Ala Pro Gln Glu Ile Pro Ile
325 330 335
Gly Ile Ile Thr Ala Leu Ile Gly Ala Pro Phe Leu Leu Ile Leu Val
340 345 350
Arg Arg Met His Thr Tyr
355
<210> 487
<211> 364
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(364)
<223> FRXA01419
<400> 487
gcgcccactc atcggcgagc ttcaggagat gaggttgatg ctccattgat aatttctttc 60
gctaatagtc aaatgatcat ttgagtgtta gtgttttctc atg ctt ctt tcc gcc 115
Met Leu Leu Ser Ala
1 5
cgc aca cac acg agt ttc caa gaa ctt gga ctc aat gct agt cgg cgc 163
Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu Asn Ala Ser Arg Arg
10 15 20
aaa gca atc aac tgg aca ctg gca ctc act gtg gtg cta att gcc tcc 211
Lys Ala Ile Asn Trp Thr Leu Ala Leu Thr Val Val Leu Ile Ala Ser
25 30 35
atg ttt gtt ggc gtg ctc atc ggt gca tcc ggg acc tca gtg ttt tcc 259
Met Phe Val Gly Val Leu Ile Gly Ala Ser Gly Thr Ser Val Phe Ser
40 45 50
acg tgg acc gta att agc cac cat ctt ttt ggc act gag cta ggt ggc 307
Thr Trp Thr Val Ile Ser His His Leu Phe Gly Thr Glu Leu Gly Gly
55 60 65
tcc gac act gcc gac gcc atc att tgg tac atc cgc acc cca cgc gtc 355
Ser Asp Thr Ala Asp Ala Ile Ile Trp Tyr Ile Arg Thr Pro Arg Val
70 75 80 85
ttg ctc gct 364
Leu Leu Ala
<210> 488
<211> 88
<212> PRT
<213> Corynebacterium glutamicum
<400> 488
Met Leu Leu Ser Ala Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu
1 5 10 15
Asn Ala Ser Arg Arg Lys Ala Ile Asn Trp Thr Leu Ala Leu Thr Val
20 25 30
Val Leu Ile Ala Ser Met Phe Val Gly Val Leu Ile Gly Ala Ser Gly
35 40 45
Thr Ser Val Phe Ser Thr Trp Thr Val Ile Ser His His Leu Phe Gly
50 55 60
Thr Glu Leu Gly Gly Ser Asp Thr Ala Asp Ala Ile Ile Trp Tyr Ile
65 70 75 80
Arg Thr Pro Arg Val Leu Leu Ala
85
<210> 489
<211> 744
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(721)
<223> FRXA02794
<400> 489
tgaactcagg tgccagttgc ggtgcggccg ctgccttact gttcggagtg ggcgctggat 60
ttggcgatta cgccctccaa gcagcgcgtt tctcggcgca atg gca gct tcc gga 115
Met Ala Ala Ser Gly
1 5
ttg atc ttc ttc gtg gcg cgc gca gcg ggg cgc atc tcc tcg acc cgc 163
Leu Ile Phe Phe Val Ala Arg Ala Ala Gly Arg Ile Ser Ser Thr Arg
10 15 20
ttg ttg atg tcc ggc gta gcg atc gga tac atg ctc tct gcg gca aca 211
Leu Leu Met Ser Gly Val Ala Ile Gly Tyr Met Leu Ser Ala Ala Thr
25 30 35
agc ttt ctc atc ttc tcc tcc gac tcc gcc gaa ggc agc cgc tcc gtg 259
Ser Phe Leu Ile Phe Ser Ser Asp Ser Ala Glu Gly Ser Arg Ser Val
40 45 50
ttg ttc tgg ctg ctt gga tcc tta gga ctt gcc gca tgg aat ggg ccg 307
Leu Phe Trp Leu Leu Gly Ser Leu Gly Leu Ala Ala Trp Asn Gly Pro
55 60 65
atg gcg atc atc ttc ctc atc gtg ggc att gcc ctg gcg ttg ctc atg 355
Met Ala Ile Ile Phe Leu Ile Val Gly Ile Ala Leu Ala Leu Leu Met
70 75 80 85
gtg ttg ggt ccg caa ttg gat gcc tta aac tcc ggc gat gaa acc gca 403
Val Leu Gly Pro Gln Leu Asp Ala Leu Asn Ser Gly Asp Glu Thr Ala
90 95 100
ctt acc ttg gga gta tcc cct gat cgc ctc cgc att ctc ctc ctg gtg 451
Leu Thr Leu Gly Val Ser Pro Asp Arg Leu Arg Ile Leu Leu Leu Val
105 110 115
atc acc tgc ctg ctg gtg gga tcc atg gtt gcc atg gcc ggc agc atc 499
Ile Thr Cys Leu Leu Val Gly Ser Met Val Ala Met Ala Gly Ser Ile
120 125 130
gga ttc atc ggc ctt gtc atc ccc cac ctg gcc agg cgt ttt gtt agt 547
Gly Phe Ile Gly Leu Val Ile Pro His Leu Ala Arg Arg Phe Val Ser
135 140 145
gga aaa cac cga ctc atg ctg cct gta tcc gcg ttg atg ggc gca att 595
Gly Lys His Arg Leu Met Leu Pro Val Ser Ala Leu Met Gly Ala Ile
150 155 160 165
ttg ctc atc tgg gct gat atc gcc gcc cgc acc ctg ctt gcg ccc caa 643
Leu Leu Ile Trp Ala Asp Ile Ala Ala Arg Thr Leu Leu Ala Pro Gln
170 175 180
gag att ccc atc ggc atc atc acc gca ctc atc gga gca ccc ttc ctc 691
Glu Ile Pro Ile Gly Ile Ile Thr Ala Leu Ile Gly Ala Pro Phe Leu
185 190 195
ctg att ctg gtt cgc cgg atg cac acc tac tgatttttaa ggaattatgc 741
Leu Ile Leu Val Arg Arg Met His Thr Tyr
200 205
gta 744
<210> 490
<211> 207
<212> PRT
<213> Corynebacterium glutamicum
<400> 490
Met Ala Ala Ser Gly Leu Ile Phe Phe Val Ala Arg Ala Ala Gly Arg
1 5 10 15
Ile Ser Ser Thr Arg Leu Leu Met Ser Gly Val Ala Ile Gly Tyr Met
20 25 30
Leu Ser Ala Ala Thr Ser Phe Leu Ile Phe Ser Ser Asp Ser Ala Glu
35 40 45
Gly Ser Arg Ser Val Leu Phe Trp Leu Leu Gly Ser Leu Gly Leu Ala
50 55 60
Ala Trp Asn Gly Pro Met Ala Ile Ile Phe Leu Ile Val Gly Ile Ala
65 70 75 80
Leu Ala Leu Leu Met Val Leu Gly Pro Gln Leu Asp Ala Leu Asn Ser
85 90 95
Gly Asp Glu Thr Ala Leu Thr Leu Gly Val Ser Pro Asp Arg Leu Arg
100 105 110
Ile Leu Leu Leu Val Ile Thr Cys Leu Leu Val Gly Ser Met Val Ala
115 120 125
Met Ala Gly Ser Ile Gly Phe Ile Gly Leu Val Ile Pro His Leu Ala
130 135 140
Arg Arg Phe Val Ser Gly Lys His Arg Leu Met Leu Pro Val Ser Ala
145 150 155 160
Leu Met Gly Ala Ile Leu Leu Ile Trp Ala Asp Ile Ala Ala Arg Thr
165 170 175
Leu Leu Ala Pro Gln Glu Ile Pro Ile Gly Ile Ile Thr Ala Leu Ile
180 185 190
Gly Ala Pro Phe Leu Leu Ile Leu Val Arg Arg Met His Thr Tyr
195 200 205
<210> 491
<211> 1140
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1117)
<223> RXN03079
<400> 491
gagcggggtt gctatcggcc gaaagtttag ggttttgttc aatctgttgg ttagtattgc 60
ttgggtaaac aagtcataac aattttcatt aagggtcgtt ttg tcg cgc aca ggt 115
Leu Ser Arg Thr Gly
1 5
gtt tcg aaa aaa cca aag ctc acc gct cct gtt gtc atc atc ggc acc 163
Val Ser Lys Lys Pro Lys Leu Thr Ala Pro Val Val Ile Ile Gly Thr
10 15 20
ctc gtc ttg ttg atc atc gcc ttc acc gct tcc ctc atg ctg ggt ccc 211
Leu Val Leu Leu Ile Ile Ala Phe Thr Ala Ser Leu Met Leu Gly Pro
25 30 35
gtg acg gtt cca ttg aat gag ctt gca acc aac ccc gtt gtc acc gat 259
Val Thr Val Pro Leu Asn Glu Leu Ala Thr Asn Pro Val Val Thr Asp
40 45 50
atc cgt gca cca cgc att atc atc gca gca ttg gtg ggt gcg gcg ctg 307
Ile Arg Ala Pro Arg Ile Ile Ile Ala Ala Leu Val Gly Ala Ala Leu
55 60 65
gct gtc tcc ggt gcg atc atg cag acg gtg ttt cac aac ccg ttg gcg 355
Ala Val Ser Gly Ala Ile Met Gln Thr Val Phe His Asn Pro Leu Ala
70 75 80 85
gat ccc ggc att gtg ggt gtg tcc tcc ggt gca gct gtt gca gct gtc 403
Asp Pro Gly Ile Val Gly Val Ser Ser Gly Ala Ala Val Ala Ala Val
90 95 100
ttg gcg att gtc acc ggt gcg agt ttc ttt ggc caa tgg acc gtt cct 451
Leu Ala Ile Val Thr Gly Ala Ser Phe Phe Gly Gln Trp Thr Val Pro
105 110 115
ttt gcg gcc ttc gtg ggc gca ttg gtc acg gtg gct gtg gta tat ttg 499
Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val Ala Val Val Tyr Leu
120 125 130
atc gct agt tcc cgc gcg atg gat ggc cgt ggc gca gat ccg gcc acg 547
Ile Ala Ser Ser Arg Ala Met Asp Gly Arg Gly Ala Asp Pro Ala Thr
135 140 145
ttg gta ctg gtc ggc atg gct atc act gcc ttt ttg ggt gct gtt att 595
Leu Val Leu Val Gly Met Ala Ile Thr Ala Phe Leu Gly Ala Val Ile
150 155 160 165
tcc agc gcc act gcg aac gca cca caa gat tct gag ctt cga tcc gtg 643
Ser Ser Ala Thr Ala Asn Ala Pro Gln Asp Ser Glu Leu Arg Ser Val
170 175 180
acg ttt tgg ctc aac ggc gat ctg gta tct cgg acg tgg gaa cat gtg 691
Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg Thr Trp Glu His Val
185 190 195
ggc gtt gca ata atc ccc att atc gtt ggg ttg att cta gct atc ggc 739
Gly Val Ala Ile Ile Pro Ile Ile Val Gly Leu Ile Leu Ala Ile Gly
200 205 210
ggt tcc cgc gat ctg aac ttg ttg ctg ctg ggt gat tcc aca gcg caa 787
Gly Ser Arg Asp Leu Asn Leu Leu Leu Leu Gly Asp Ser Thr Ala Gln
215 220 225
aca tct gga ctc aac gtc aac cgc gca cgc atc att ttg cta gca ctt 835
Thr Ser Gly Leu Asn Val Asn Arg Ala Arg Ile Ile Leu Leu Ala Leu
230 235 240 245
gcg gca ctg ctc acc gcc aca gct gtt gcg gtc tcc ggc acc att acg 883
Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Val Ser Gly Thr Ile Thr
250 255 260
ttt gtt gga ttg gta gta ccc cac ctg gtg cgc att gtt tta ggt gcc 931
Phe Val Gly Leu Val Val Pro His Leu Val Arg Ile Val Leu Gly Ala
265 270 275
gat cac cga gcg tta ctc ccg gcc gcc gcg att ttg ggc gcc acg ttt 979
Asp His Arg Ala Leu Leu Pro Ala Ala Ala Ile Leu Gly Ala Thr Phe
280 285 290
gtt atc gtt tcc gac act gtt gcc cgc atg atc ttc tcc ccc atc gtc 1027
Val Ile Val Ser Asp Thr Val Ala Arg Met Ile Phe Ser Pro Ile Val
295 300 305
ttg caa aca ggc gtg gtg gtg gcg ttc att ggc tca cca att ttc ctt 1075
Leu Gln Thr Gly Val Val Val Ala Phe Ile Gly Ser Pro Ile Phe Leu
310 315 320 325
tat tta ctg ctc agc atg cgc aag cga cgc gga ttg ggg ctg 1117
Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly Leu Gly Leu
330 335
taaaaactca tgcctcaatt agt 1140
<210> 492
<211> 339
<212> PRT
<213> Corynebacterium glutamicum
<400> 492
Leu Ser Arg Thr Gly Val Ser Lys Lys Pro Lys Leu Thr Ala Pro Val
1 5 10 15
Val Ile Ile Gly Thr Leu Val Leu Leu Ile Ile Ala Phe Thr Ala Ser
20 25 30
Leu Met Leu Gly Pro Val Thr Val Pro Leu Asn Glu Leu Ala Thr Asn
35 40 45
Pro Val Val Thr Asp Ile Arg Ala Pro Arg Ile Ile Ile Ala Ala Leu
50 55 60
Val Gly Ala Ala Leu Ala Val Ser Gly Ala Ile Met Gln Thr Val Phe
65 70 75 80
His Asn Pro Leu Ala Asp Pro Gly Ile Val Gly Val Ser Ser Gly Ala
85 90 95
Ala Val Ala Ala Val Leu Ala Ile Val Thr Gly Ala Ser Phe Phe Gly
100 105 110
Gln Trp Thr Val Pro Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val
115 120 125
Ala Val Val Tyr Leu Ile Ala Ser Ser Arg Ala Met Asp Gly Arg Gly
130 135 140
Ala Asp Pro Ala Thr Leu Val Leu Val Gly Met Ala Ile Thr Ala Phe
145 150 155 160
Leu Gly Ala Val Ile Ser Ser Ala Thr Ala Asn Ala Pro Gln Asp Ser
165 170 175
Glu Leu Arg Ser Val Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg
180 185 190
Thr Trp Glu His Val Gly Val Ala Ile Ile Pro Ile Ile Val Gly Leu
195 200 205
Ile Leu Ala Ile Gly Gly Ser Arg Asp Leu Asn Leu Leu Leu Leu Gly
210 215 220
Asp Ser Thr Ala Gln Thr Ser Gly Leu Asn Val Asn Arg Ala Arg Ile
225 230 235 240
Ile Leu Leu Ala Leu Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Val
245 250 255
Ser Gly Thr Ile Thr Phe Val Gly Leu Val Val Pro His Leu Val Arg
260 265 270
Ile Val Leu Gly Ala Asp His Arg Ala Leu Leu Pro Ala Ala Ala Ile
275 280 285
Leu Gly Ala Thr Phe Val Ile Val Ser Asp Thr Val Ala Arg Met Ile
290 295 300
Phe Ser Pro Ile Val Leu Gln Thr Gly Val Val Val Ala Phe Ile Gly
305 310 315 320
Ser Pro Ile Phe Leu Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly
325 330 335
Leu Gly Leu
<210> 493
<211> 1140
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1117)
<223> FRXA02865
<400> 493
gagcggggtt gctatcggcc gaaagtttag ggttttgttc aatctgttgg ttagtattgc 60
ttgggtaaac aagtcataac aattttcatt aagggtcgtt ttg tcg cgc aca ggt 115
Leu Ser Arg Thr Gly
1 5
gtt tcg aaa aaa cca aag ctc acc gct cct gtt gtc atc atc ggc acc 163
Val Ser Lys Lys Pro Lys Leu Thr Ala Pro Val Val Ile Ile Gly Thr
10 15 20
ctc gtc ttg ttg atc atc gcc ttc acc gct tcc ctc atg ctg ggt ccc 211
Leu Val Leu Leu Ile Ile Ala Phe Thr Ala Ser Leu Met Leu Gly Pro
25 30 35
gtg acg gtt cca ttg aat gag ctt gca acc aac ccc gtt gtc acc gat 259
Val Thr Val Pro Leu Asn Glu Leu Ala Thr Asn Pro Val Val Thr Asp
40 45 50
atc cgt gca cca cgc att atc atc gca gca ttg gtg ggt gcg gcg ctg 307
Ile Arg Ala Pro Arg Ile Ile Ile Ala Ala Leu Val Gly Ala Ala Leu
55 60 65
gct gtc tcc ggt gcg atc atg cag acg gtg ttt cac aac ccg ttg gcg 355
Ala Val Ser Gly Ala Ile Met Gln Thr Val Phe His Asn Pro Leu Ala
70 75 80 85
gat ccc ggc att gtg ggt gtg tcc tcc ggt gca gct gtt gca gct gtc 403
Asp Pro Gly Ile Val Gly Val Ser Ser Gly Ala Ala Val Ala Ala Val
90 95 100
ttg gcg att gtc acc ggt gcg agt ttc ttt ggc caa tgg acc gtt cct 451
Leu Ala Ile Val Thr Gly Ala Ser Phe Phe Gly Gln Trp Thr Val Pro
105 110 115
ttt gcg gcc ttc gtg ggc gca ttg gtc acg gtg gct gtg gta tat ttg 499
Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val Ala Val Val Tyr Leu
120 125 130
atc gct agt tcc cgc gcg atg gat ggc cgt ggc gca gat ccg gcc acg 547
Ile Ala Ser Ser Arg Ala Met Asp Gly Arg Gly Ala Asp Pro Ala Thr
135 140 145
ttg gta ctg gtc ggc atg gct atc act gcc ttt ttg ggt gct gtt att 595
Leu Val Leu Val Gly Met Ala Ile Thr Ala Phe Leu Gly Ala Val Ile
150 155 160 165
tcc agc gcc act gcg aac gca cca caa gat tct gag ctt cga tcc gtg 643
Ser Ser Ala Thr Ala Asn Ala Pro Gln Asp Ser Glu Leu Arg Ser Val
170 175 180
acg ttt tgg ctc aac ggc gat ctg gta tct cgg acg tgg gaa cat gtg 691
Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg Thr Trp Glu His Val
185 190 195
ggc gtt gca ata atc ccc att atc gtt ggg ttg att cta gct atc ggc 739
Gly Val Ala Ile Ile Pro Ile Ile Val Gly Leu Ile Leu Ala Ile Gly
200 205 210
ggt tcc cgc gat ctg aac ttg ttg ctg ctg ggt gat tcc aca gcg caa 787
Gly Ser Arg Asp Leu Asn Leu Leu Leu Leu Gly Asp Ser Thr Ala Gln
215 220 225
aca tct gga ctc aac gtc aac cgc gca cgc atc att ttg cta gca ctt 835
Thr Ser Gly Leu Asn Val Asn Arg Ala Arg Ile Ile Leu Leu Ala Leu
230 235 240 245
gcg gca ctg ctc acc gcc aca gct gtt gcg gtc tcc ggc acc att acg 883
Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Val Ser Gly Thr Ile Thr
250 255 260
ttt gtt gga ttg gta gta ccc cac ctg gtg cgc att gtt tta ggt gcc 931
Phe Val Gly Leu Val Val Pro His Leu Val Arg Ile Val Leu Gly Ala
265 270 275
gat cac cga gcg tta ctc ccg gcc gcc gcg att ttg ggc gcc acg ttt 979
Asp His Arg Ala Leu Leu Pro Ala Ala Ala Ile Leu Gly Ala Thr Phe
280 285 290
gtt atc gtt tcc gac act gtt gcc cgc atg atc ttc tcc ccc atc gtc 1027
Val Ile Val Ser Asp Thr Val Ala Arg Met Ile Phe Ser Pro Ile Val
295 300 305
ttg caa aca ggc gtg gtg gtg gcg ttc att ggc tca cca att ttc ctt 1075
Leu Gln Thr Gly Val Val Val Ala Phe Ile Gly Ser Pro Ile Phe Leu
310 315 320 325
tat tta ctg ctc agc atg cgc aag cga cgc gga ttg ggg ctg 1117
Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly Leu Gly Leu
330 335
taaaaactca tgcctcaatt agt 1140
<210> 494
<211> 339
<212> PRT
<213> Corynebacterium glutamicum
<400> 494
Leu Ser Arg Thr Gly Val Ser Lys Lys Pro Lys Leu Thr Ala Pro Val
1 5 10 15
Val Ile Ile Gly Thr Leu Val Leu Leu Ile Ile Ala Phe Thr Ala Ser
20 25 30
Leu Met Leu Gly Pro Val Thr Val Pro Leu Asn Glu Leu Ala Thr Asn
35 40 45
Pro Val Val Thr Asp Ile Arg Ala Pro Arg Ile Ile Ile Ala Ala Leu
50 55 60
Val Gly Ala Ala Leu Ala Val Ser Gly Ala Ile Met Gln Thr Val Phe
65 70 75 80
His Asn Pro Leu Ala Asp Pro Gly Ile Val Gly Val Ser Ser Gly Ala
85 90 95
Ala Val Ala Ala Val Leu Ala Ile Val Thr Gly Ala Ser Phe Phe Gly
100 105 110
Gln Trp Thr Val Pro Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val
115 120 125
Ala Val Val Tyr Leu Ile Ala Ser Ser Arg Ala Met Asp Gly Arg Gly
130 135 140
Ala Asp Pro Ala Thr Leu Val Leu Val Gly Met Ala Ile Thr Ala Phe
145 150 155 160
Leu Gly Ala Val Ile Ser Ser Ala Thr Ala Asn Ala Pro Gln Asp Ser
165 170 175
Glu Leu Arg Ser Val Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg
180 185 190
Thr Trp Glu His Val Gly Val Ala Ile Ile Pro Ile Ile Val Gly Leu
195 200 205
Ile Leu Ala Ile Gly Gly Ser Arg Asp Leu Asn Leu Leu Leu Leu Gly
210 215 220
Asp Ser Thr Ala Gln Thr Ser Gly Leu Asn Val Asn Arg Ala Arg Ile
225 230 235 240
Ile Leu Leu Ala Leu Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Val
245 250 255
Ser Gly Thr Ile Thr Phe Val Gly Leu Val Val Pro His Leu Val Arg
260 265 270
Ile Val Leu Gly Ala Asp His Arg Ala Leu Leu Pro Ala Ala Ala Ile
275 280 285
Leu Gly Ala Thr Phe Val Ile Val Ser Asp Thr Val Ala Arg Met Ile
290 295 300
Phe Ser Pro Ile Val Leu Gln Thr Gly Val Val Val Ala Phe Ile Gly
305 310 315 320
Ser Pro Ile Phe Leu Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly
325 330 335
Leu Gly Leu
<210> 495
<211> 1695
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1672)
<223> RXA00181
<400> 495
gtatattcag acacccacgt cgattagtgt tgtagttcac agtgcttatt ttttatttgt 60
atctttgcac gtttgtcccc tacccaaaag gagaaacctc atg agc gat aac acc 115
Met Ser Asp Asn Thr
1 5
tgg ttc atc ata gcc atc gtt atc tat atg ttg gtg atg gtg ctc atc 163
Trp Phe Ile Ile Ala Ile Val Ile Tyr Met Leu Val Met Val Leu Ile
10 15 20
ggc tat tgg agt tac cgc aag aca gaa aaa tac gac gac tac atg ctc 211
Gly Tyr Trp Ser Tyr Arg Lys Thr Glu Lys Tyr Asp Asp Tyr Met Leu
25 30 35
gcc ggc cgc ggg ctc aac cct ttt gtt gcc gca atg tcc gca ggt gcc 259
Ala Gly Arg Gly Leu Asn Pro Phe Val Ala Ala Met Ser Ala Gly Ala
40 45 50
tca gat atg tca ggt tgg ctg ctc atg ggt ctg ccc ggc gcg ctg ttt 307
Ser Asp Met Ser Gly Trp Leu Leu Met Gly Leu Pro Gly Ala Leu Phe
55 60 65
gtc acc ggc atg tcc gag ttg tgg atc gca gtc gga ctc acc att ggt 355
Val Thr Gly Met Ser Glu Leu Trp Ile Ala Val Gly Leu Thr Ile Gly
70 75 80 85
gca tgg gcg aac tgg atg tgg gtg gca cct cgt ctt cgt tct tat tcc 403
Ala Trp Ala Asn Trp Met Trp Val Ala Pro Arg Leu Arg Ser Tyr Ser
90 95 100
gaa atc tcg gcc aac tca atc acc ctg cct tca ttc ttt gag aac cga 451
Glu Ile Ser Ala Asn Ser Ile Thr Leu Pro Ser Phe Phe Glu Asn Arg
105 110 115
ctt cgc gat aaa tct cgc gcg ctt cgc atc att gca gca cta att atc 499
Leu Arg Asp Lys Ser Arg Ala Leu Arg Ile Ile Ala Ala Leu Ile Ile
120 125 130
att gtg ttc ttc acc ttc tac att tct tca ggc atg gtt gct ggt gga 547
Ile Val Phe Phe Thr Phe Tyr Ile Ser Ser Gly Met Val Ala Gly Gly
135 140 145
gtg tat tgg gag tcc acg ttt ggt gga gat tat cta ctc ggt atg gcc 595
Val Tyr Trp Glu Ser Thr Phe Gly Gly Asp Tyr Leu Leu Gly Met Ala
150 155 160 165
att gtc gca ggt gtg aca gtg ctg tat acc ttc att gga gga ttc ctt 643
Ile Val Ala Gly Val Thr Val Leu Tyr Thr Phe Ile Gly Gly Phe Leu
170 175 180
gct gtg tct tat aca gac gca gtt cag ggg act atc atg ttc ttc tcg 691
Ala Val Ser Tyr Thr Asp Ala Val Gln Gly Thr Ile Met Phe Phe Ser
185 190 195
ttg atc atc gtg cca gtc atg gca tat ttc gca ctg gcg aac ccc atg 739
Leu Ile Ile Val Pro Val Met Ala Tyr Phe Ala Leu Ala Asn Pro Met
200 205 210
gat att tgg agc ttt gca aac tct aat gat tac ggc ccg cac acc gat 787
Asp Ile Trp Ser Phe Ala Asn Ser Asn Asp Tyr Gly Pro His Thr Asp
215 220 225
gga att ggc aat ccc acc tac ttc tcc atg atc agt ggc att tct gca 835
Gly Ile Gly Asn Pro Thr Tyr Phe Ser Met Ile Ser Gly Ile Ser Ala
230 235 240 245
gca gca atc att ggt aac tta ggt tgg ggt ctt gga tac ttc ggc cag 883
Ala Ala Ile Ile Gly Asn Leu Gly Trp Gly Leu Gly Tyr Phe Gly Gln
250 255 260
cca cac att gtg gtt cgt ttc atg gca ctt cgc aca cca gct gaa gca 931
Pro His Ile Val Val Arg Phe Met Ala Leu Arg Thr Pro Ala Glu Ala
265 270 275
aag caa ggt cgt cgc atc ggt att tcc tgg atg ata atc tgc ctg att 979
Lys Gln Gly Arg Arg Ile Gly Ile Ser Trp Met Ile Ile Cys Leu Ile
280 285 290
ggt gca acc ttt acc gca att atc tcc aca gtt ttc ttt gca caa aac 1027
Gly Ala Thr Phe Thr Ala Ile Ile Ser Thr Val Phe Phe Ala Gln Asn
295 300 305
ccc gac gcc aac atc act gac aca agg gct tat gag tcc atc ttc cta 1075
Pro Asp Ala Asn Ile Thr Asp Thr Arg Ala Tyr Glu Ser Ile Phe Leu
310 315 320 325
gat ctt gcc cgg atg ctg ttc cac cca ttg atc gct gga ctt att ctg 1123
Asp Leu Ala Arg Met Leu Phe His Pro Leu Ile Ala Gly Leu Ile Leu
330 335 340
act gct gtt ctc gcg gcc atc atg tct acc atg tcg tca cag ctg ctg 1171
Thr Ala Val Leu Ala Ala Ile Met Ser Thr Met Ser Ser Gln Leu Leu
345 350 355
gtc acc gca tct tcc ctg att gag gac ctg ctg aag gta gtt aaa aag 1219
Val Thr Ala Ser Ser Leu Ile Glu Asp Leu Leu Lys Val Val Lys Lys
360 365 370
gac tcg ctg agc gaa cgc acc ctg atc atg ctg tct cgt gcc aca gtc 1267
Asp Ser Leu Ser Glu Arg Thr Leu Ile Met Leu Ser Arg Ala Thr Val
375 380 385
atc att ctg gcg atc att gca gca gcc atg gct att aac ccg tct gat 1315
Ile Ile Leu Ala Ile Ile Ala Ala Ala Met Ala Ile Asn Pro Ser Asp
390 395 400 405
tcc atc ctc gga ttg gtg gga ttt gcg tgg gca gga ttc ggc tct gca 1363
Ser Ile Leu Gly Leu Val Gly Phe Ala Trp Ala Gly Phe Gly Ser Ala
410 415 420
ttt ggt ccg atc ata ctt gct agc ctt tat tgg aag cgt ctc aac gcc 1411
Phe Gly Pro Ile Ile Leu Ala Ser Leu Tyr Trp Lys Arg Leu Asn Ala
425 430 435
gcc ggc gct atc tcc ggc atg att act ggt gct att gtc tcc atc gcg 1459
Ala Gly Ala Ile Ser Gly Met Ile Thr Gly Ala Ile Val Ser Ile Ala
440 445 450
tgg ggt atg tcc cca cta agc gat acg ttg tat gaa atc atc cca ggt 1507
Trp Gly Met Ser Pro Leu Ser Asp Thr Leu Tyr Glu Ile Ile Pro Gly
455 460 465
ttc gcc ttg gca acc atc gtg atg gtc gtt gtt tcc ctc ctg aca aag 1555
Phe Ala Leu Ala Thr Ile Val Met Val Val Val Ser Leu Leu Thr Lys
470 475 480 485
gaa ccc tcc gaa gaa atc ctc aac gag ttt gaa acc gcc aag gat ctt 1603
Glu Pro Ser Glu Glu Ile Leu Asn Glu Phe Glu Thr Ala Lys Asp Leu
490 495 500
gct gcc gct gtg gaa tca aac gag gat gtt gat ttc gct gac gca gct 1651
Ala Ala Ala Val Glu Ser Asn Glu Asp Val Asp Phe Ala Asp Ala Ala
505 510 515
cag aag ctt tcg aaa gaa agt taagccttag agggaaccaa acg 1695
Gln Lys Leu Ser Lys Glu Ser
520
<210> 496
<211> 524
<212> PRT
<213> Corynebacterium glutamicum
<400> 496
Met Ser Asp Asn Thr Trp Phe Ile Ile Ala Ile Val Ile Tyr Met Leu
1 5 10 15
Val Met Val Leu Ile Gly Tyr Trp Ser Tyr Arg Lys Thr Glu Lys Tyr
20 25 30
Asp Asp Tyr Met Leu Ala Gly Arg Gly Leu Asn Pro Phe Val Ala Ala
35 40 45
Met Ser Ala Gly Ala Ser Asp Met Ser Gly Trp Leu Leu Met Gly Leu
50 55 60
Pro Gly Ala Leu Phe Val Thr Gly Met Ser Glu Leu Trp Ile Ala Val
65 70 75 80
Gly Leu Thr Ile Gly Ala Trp Ala Asn Trp Met Trp Val Ala Pro Arg
85 90 95
Leu Arg Ser Tyr Ser Glu Ile Ser Ala Asn Ser Ile Thr Leu Pro Ser
100 105 110
Phe Phe Glu Asn Arg Leu Arg Asp Lys Ser Arg Ala Leu Arg Ile Ile
115 120 125
Ala Ala Leu Ile Ile Ile Val Phe Phe Thr Phe Tyr Ile Ser Ser Gly
130 135 140
Met Val Ala Gly Gly Val Tyr Trp Glu Ser Thr Phe Gly Gly Asp Tyr
145 150 155 160
Leu Leu Gly Met Ala Ile Val Ala Gly Val Thr Val Leu Tyr Thr Phe
165 170 175
Ile Gly Gly Phe Leu Ala Val Ser Tyr Thr Asp Ala Val Gln Gly Thr
180 185 190
Ile Met Phe Phe Ser Leu Ile Ile Val Pro Val Met Ala Tyr Phe Ala
195 200 205
Leu Ala Asn Pro Met Asp Ile Trp Ser Phe Ala Asn Ser Asn Asp Tyr
210 215 220
Gly Pro His Thr Asp Gly Ile Gly Asn Pro Thr Tyr Phe Ser Met Ile
225 230 235 240
Ser Gly Ile Ser Ala Ala Ala Ile Ile Gly Asn Leu Gly Trp Gly Leu
245 250 255
Gly Tyr Phe Gly Gln Pro His Ile Val Val Arg Phe Met Ala Leu Arg
260 265 270
Thr Pro Ala Glu Ala Lys Gln Gly Arg Arg Ile Gly Ile Ser Trp Met
275 280 285
Ile Ile Cys Leu Ile Gly Ala Thr Phe Thr Ala Ile Ile Ser Thr Val
290 295 300
Phe Phe Ala Gln Asn Pro Asp Ala Asn Ile Thr Asp Thr Arg Ala Tyr
305 310 315 320
Glu Ser Ile Phe Leu Asp Leu Ala Arg Met Leu Phe His Pro Leu Ile
325 330 335
Ala Gly Leu Ile Leu Thr Ala Val Leu Ala Ala Ile Met Ser Thr Met
340 345 350
Ser Ser Gln Leu Leu Val Thr Ala Ser Ser Leu Ile Glu Asp Leu Leu
355 360 365
Lys Val Val Lys Lys Asp Ser Leu Ser Glu Arg Thr Leu Ile Met Leu
370 375 380
Ser Arg Ala Thr Val Ile Ile Leu Ala Ile Ile Ala Ala Ala Met Ala
385 390 395 400
Ile Asn Pro Ser Asp Ser Ile Leu Gly Leu Val Gly Phe Ala Trp Ala
405 410 415
Gly Phe Gly Ser Ala Phe Gly Pro Ile Ile Leu Ala Ser Leu Tyr Trp
420 425 430
Lys Arg Leu Asn Ala Ala Gly Ala Ile Ser Gly Met Ile Thr Gly Ala
435 440 445
Ile Val Ser Ile Ala Trp Gly Met Ser Pro Leu Ser Asp Thr Leu Tyr
450 455 460
Glu Ile Ile Pro Gly Phe Ala Leu Ala Thr Ile Val Met Val Val Val
465 470 475 480
Ser Leu Leu Thr Lys Glu Pro Ser Glu Glu Ile Leu Asn Glu Phe Glu
485 490 495
Thr Ala Lys Asp Leu Ala Ala Ala Val Glu Ser Asn Glu Asp Val Asp
500 505 510
Phe Ala Asp Ala Ala Gln Lys Leu Ser Lys Glu Ser
515 520
<210> 497
<211> 1476
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1453)
<223> RXA00591
<400> 497
gcaacgccac aggcaaaatc caaaagaaca tcctgcgaga cttcaccatc cccgtttcat 60
aaacccccca acgtcacttt gaaaacactt ggagaacgca atg act aca tct tcc 115
Met Thr Thr Ser Ser
1 5
aca gct tcg ccg atc gct gaa tta caa aac ctc agc ccg aag caa aga 163
Thr Ala Ser Pro Ile Ala Glu Leu Gln Asn Leu Ser Pro Lys Gln Arg
10 15 20
aaa tca gaa tcc cgg cgc gcg att ata tcc agc tac ttg ggc tcc acg 211
Lys Ser Glu Ser Arg Arg Ala Ile Ile Ser Ser Tyr Leu Gly Ser Thr
25 30 35
atc gag ttc tat gac ttc ctg tta tat gcc gca gcc tcc gcg acg gta 259
Ile Glu Phe Tyr Asp Phe Leu Leu Tyr Ala Ala Ala Ser Ala Thr Val
40 45 50
ttc ccc gca gtg ttc ttt acc aat ctc gat ccg ctg gct gga acc att 307
Phe Pro Ala Val Phe Phe Thr Asn Leu Asp Pro Leu Ala Gly Thr Ile
55 60 65
gcc gcc tac gga acc ttc gcc gca ggt tat tta gct agg cca ctt ggt 355
Ala Ala Tyr Gly Thr Phe Ala Ala Gly Tyr Leu Ala Arg Pro Leu Gly
70 75 80 85
gga gca atc ttc gga cac ttc ggt gac cgt ctt gga cgc aag aag atg 403
Gly Ala Ile Phe Gly His Phe Gly Asp Arg Leu Gly Arg Lys Lys Met
90 95 100
ctt gtg ttg tcc atg ctc atc atg ggt gtg gca tcc aca tgc atc ggc 451
Leu Val Leu Ser Met Leu Ile Met Gly Val Ala Ser Thr Cys Ile Gly
105 110 115
ctt gtc cca agc gct gaa atg atc gga agc atg ggc gcg gta atc ctg 499
Leu Val Pro Ser Ala Glu Met Ile Gly Ser Met Gly Ala Val Ile Leu
120 125 130
atc atg ctg cgc atc tgc caa ggc atc gct gtc ggt ggc gaa tgg ggc 547
Ile Met Leu Arg Ile Cys Gln Gly Ile Ala Val Gly Gly Glu Trp Gly
135 140 145
gga gct gcc ctc atg gcg ctc gag cac tca gat tcc aag aag cgc gga 595
Gly Ala Ala Leu Met Ala Leu Glu His Ser Asp Ser Lys Lys Arg Gly
150 155 160 165
ttc gcc gcc tcc ttc acc aac gct ggt gca cca acc ggc gct gca ctg 643
Phe Ala Ala Ser Phe Thr Asn Ala Gly Ala Pro Thr Gly Ala Ala Leu
170 175 180
gga acc ttc gcg ctc ggt acc gca tct gct gtt ctc acc cag gag caa 691
Gly Thr Phe Ala Leu Gly Thr Ala Ser Ala Val Leu Thr Gln Glu Gln
185 190 195
ttc ctt tca tgg ggt tgg cgc atc cca ttc ctg ctc tct ttc gtt ctg 739
Phe Leu Ser Trp Gly Trp Arg Ile Pro Phe Leu Leu Ser Phe Val Leu
200 205 210
ctg att gtc ggc ttg gtt atc cgc gcg aaa gtt agc gaa tca cca ctg 787
Leu Ile Val Gly Leu Val Ile Arg Ala Lys Val Ser Glu Ser Pro Leu
215 220 225
ttc gca gct gca gcg gcc gcc gaa aaa gcc aag cca acc gaa cgt aaa 835
Phe Ala Ala Ala Ala Ala Ala Glu Lys Ala Lys Pro Thr Glu Arg Lys
230 235 240 245
gtc ccc ctc ttg cag gtt ctt cgc cga cca aag gca ctg atc ttg acc 883
Val Pro Leu Leu Gln Val Leu Arg Arg Pro Lys Ala Leu Ile Leu Thr
250 255 260
atg ctt ggc ggc gca tca gga ttc gga ctt caa gtt ctc ttg tcc acc 931
Met Leu Gly Gly Ala Ser Gly Phe Gly Leu Gln Val Leu Leu Ser Thr
265 270 275
ttc tcc atc agc tac gca aca caa tcc ggc atc gaa aga tcc agc gtc 979
Phe Ser Ile Ser Tyr Ala Thr Gln Ser Gly Ile Glu Arg Ser Ser Val
280 285 290
ctc tac gcc ttc gca gtc gcc tca gtg ttc tct gtc ttc ttt gtg atc 1027
Leu Tyr Ala Phe Ala Val Ala Ser Val Phe Ser Val Phe Phe Val Ile
295 300 305
ctc ttc ggt cgc gta tcc gac ctc ttc gga cgc cga ccc gtc atg atc 1075
Leu Phe Gly Arg Val Ser Asp Leu Phe Gly Arg Arg Pro Val Met Ile
310 315 320 325
atc gcg ctc gta ctg ttc gtg gcc tac ctg ccg gca ttc ttc cgg atg 1123
Ile Ala Leu Val Leu Phe Val Ala Tyr Leu Pro Ala Phe Phe Arg Met
330 335 340
ctc acc tca gac aac tgg ttc atc ctg ctc tcg gca ttc acc atc gcg 1171
Leu Thr Ser Asp Asn Trp Phe Ile Leu Leu Ser Ala Phe Thr Ile Ala
345 350 355
ctc gca ctc cac gcc atg ctt tac ggc cca cta gca gcg ttt atc tcc 1219
Leu Ala Leu His Ala Met Leu Tyr Gly Pro Leu Ala Ala Phe Ile Ser
360 365 370
gaa caa ttc gga acc tcc gcg cgc tac aca ggc gca tcc ctg ggt tac 1267
Glu Gln Phe Gly Thr Ser Ala Arg Tyr Thr Gly Ala Ser Leu Gly Tyr
375 380 385
cag ttg gcc acg ctc atc ggt gca gga ttc acc cca acc atc ctg gct 1315
Gln Leu Ala Thr Leu Ile Gly Ala Gly Phe Thr Pro Thr Ile Leu Ala
390 395 400 405
agc ctc tac gcg gga cca ggc ggc gga acc tct gtc acc cca gtc atc 1363
Ser Leu Tyr Ala Gly Pro Gly Gly Gly Thr Ser Val Thr Pro Val Ile
410 415 420
gtc ttc ctc gca acg atg tcc cta gtg tcc atc atc gcc atc gca atc 1411
Val Phe Leu Ala Thr Met Ser Leu Val Ser Ile Ile Ala Ile Ala Ile
425 430 435
acc aga gaa tca aaa gac cac gat ctt tct act tac gaa cac 1453
Thr Arg Glu Ser Lys Asp His Asp Leu Ser Thr Tyr Glu His
440 445 450
taaggggacg atagggtcaa ttt 1476
<210> 498
<211> 451
<212> PRT
<213> Corynebacterium glutamicum
<400> 498
Met Thr Thr Ser Ser Thr Ala Ser Pro Ile Ala Glu Leu Gln Asn Leu
1 5 10 15
Ser Pro Lys Gln Arg Lys Ser Glu Ser Arg Arg Ala Ile Ile Ser Ser
20 25 30
Tyr Leu Gly Ser Thr Ile Glu Phe Tyr Asp Phe Leu Leu Tyr Ala Ala
35 40 45
Ala Ser Ala Thr Val Phe Pro Ala Val Phe Phe Thr Asn Leu Asp Pro
50 55 60
Leu Ala Gly Thr Ile Ala Ala Tyr Gly Thr Phe Ala Ala Gly Tyr Leu
65 70 75 80
Ala Arg Pro Leu Gly Gly Ala Ile Phe Gly His Phe Gly Asp Arg Leu
85 90 95
Gly Arg Lys Lys Met Leu Val Leu Ser Met Leu Ile Met Gly Val Ala
100 105 110
Ser Thr Cys Ile Gly Leu Val Pro Ser Ala Glu Met Ile Gly Ser Met
115 120 125
Gly Ala Val Ile Leu Ile Met Leu Arg Ile Cys Gln Gly Ile Ala Val
130 135 140
Gly Gly Glu Trp Gly Gly Ala Ala Leu Met Ala Leu Glu His Ser Asp
145 150 155 160
Ser Lys Lys Arg Gly Phe Ala Ala Ser Phe Thr Asn Ala Gly Ala Pro
165 170 175
Thr Gly Ala Ala Leu Gly Thr Phe Ala Leu Gly Thr Ala Ser Ala Val
180 185 190
Leu Thr Gln Glu Gln Phe Leu Ser Trp Gly Trp Arg Ile Pro Phe Leu
195 200 205
Leu Ser Phe Val Leu Leu Ile Val Gly Leu Val Ile Arg Ala Lys Val
210 215 220
Ser Glu Ser Pro Leu Phe Ala Ala Ala Ala Ala Ala Glu Lys Ala Lys
225 230 235 240
Pro Thr Glu Arg Lys Val Pro Leu Leu Gln Val Leu Arg Arg Pro Lys
245 250 255
Ala Leu Ile Leu Thr Met Leu Gly Gly Ala Ser Gly Phe Gly Leu Gln
260 265 270
Val Leu Leu Ser Thr Phe Ser Ile Ser Tyr Ala Thr Gln Ser Gly Ile
275 280 285
Glu Arg Ser Ser Val Leu Tyr Ala Phe Ala Val Ala Ser Val Phe Ser
290 295 300
Val Phe Phe Val Ile Leu Phe Gly Arg Val Ser Asp Leu Phe Gly Arg
305 310 315 320
Arg Pro Val Met Ile Ile Ala Leu Val Leu Phe Val Ala Tyr Leu Pro
325 330 335
Ala Phe Phe Arg Met Leu Thr Ser Asp Asn Trp Phe Ile Leu Leu Ser
340 345 350
Ala Phe Thr Ile Ala Leu Ala Leu His Ala Met Leu Tyr Gly Pro Leu
355 360 365
Ala Ala Phe Ile Ser Glu Gln Phe Gly Thr Ser Ala Arg Tyr Thr Gly
370 375 380
Ala Ser Leu Gly Tyr Gln Leu Ala Thr Leu Ile Gly Ala Gly Phe Thr
385 390 395 400
Pro Thr Ile Leu Ala Ser Leu Tyr Ala Gly Pro Gly Gly Gly Thr Ser
405 410 415
Val Thr Pro Val Ile Val Phe Leu Ala Thr Met Ser Leu Val Ser Ile
420 425 430
Ile Ala Ile Ala Ile Thr Arg Glu Ser Lys Asp His Asp Leu Ser Thr
435 440 445
Tyr Glu His
450
<210> 499
<211> 1635
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1612)
<223> RXA01629
<400> 499
caggaagaag ttaacaccgc ccaggggtgc gttggatgat gatcatctac aaacaaacat 60
tccgttatgc actcataaga tatgacgaga ggttttactc gtg agc ccg att cgc 115
Val Ser Pro Ile Arg
1 5
tca aaa aag aaa atc aag aac gaa cca aga cta aca gtc gat gac gtc 163
Ser Lys Lys Lys Ile Lys Asn Glu Pro Arg Leu Thr Val Asp Asp Val
10 15 20
aac gtt gtt ccc cca aag aag atc cgt ccg gcc att aaa ggc act gtg 211
Asn Val Val Pro Pro Lys Lys Ile Arg Pro Ala Ile Lys Gly Thr Val
25 30 35
gtg ggt aac ttc atg gag tgg tac gac ttc gga att tat ggt tat ttg 259
Val Gly Asn Phe Met Glu Trp Tyr Asp Phe Gly Ile Tyr Gly Tyr Leu
40 45 50
acg gtc acg atg acc gca gta ttt acc caa ggc ctg ccg caa gaa tgg 307
Thr Val Thr Met Thr Ala Val Phe Thr Gln Gly Leu Pro Gln Glu Trp
55 60 65
cag ttg ttg gcc gtg atg ttt ggt ttc gcg gtg tct tat tta gtt cgc 355
Gln Leu Leu Ala Val Met Phe Gly Phe Ala Val Ser Tyr Leu Val Arg
70 75 80 85
ccg ctt ggt ggc ctg gtt ctg ggt ccg ctt ggc gat aag gtt ggc cgc 403
Pro Leu Gly Gly Leu Val Leu Gly Pro Leu Gly Asp Lys Val Gly Arg
90 95 100
cag aag gtt ttg tac gta acc atg gcc atg atg gcc gtg tct acg gcg 451
Gln Lys Val Leu Tyr Val Thr Met Ala Met Met Ala Val Ser Thr Ala
105 110 115
ctg att ggc ttg ctg ccg acg gcg gcg tcg ata ggc gct tgg gct ttg 499
Leu Ile Gly Leu Leu Pro Thr Ala Ala Ser Ile Gly Ala Trp Ala Leu
120 125 130
gtg ctt ttg tac ctg ttg aag atg gtg cag gga ttt tcg act ggt ggt 547
Val Leu Leu Tyr Leu Leu Lys Met Val Gln Gly Phe Ser Thr Gly Gly
135 140 145
gaa tat gct ggt gcg acc acc tat gtt gct gag ttt gcg ccg gat cgt 595
Glu Tyr Ala Gly Ala Thr Thr Tyr Val Ala Glu Phe Ala Pro Asp Arg
150 155 160 165
cga cga ggt ttc ttc gga gct ttc cta gat atg ggt tcc tac ctg ggc 643
Arg Arg Gly Phe Phe Gly Ala Phe Leu Asp Met Gly Ser Tyr Leu Gly
170 175 180
ttt gcc gcg ggt gct tcg gtc gtg gcg att act acc tgg gtg acc act 691
Phe Ala Ala Gly Ala Ser Val Val Ala Ile Thr Thr Trp Val Thr Thr
185 190 195
cac ttc tat ggc gca act gcc atg gag gat ttc ggt tgg cgt att cct 739
His Phe Tyr Gly Ala Thr Ala Met Glu Asp Phe Gly Trp Arg Ile Pro
200 205 210
ttc ctg act gcg atc ccg ctg ggc atc att gcg gtg tac ctg cgt act 787
Phe Leu Thr Ala Ile Pro Leu Gly Ile Ile Ala Val Tyr Leu Arg Thr
215 220 225
cgt atc cct gag acc cct gcg ttt gag aac aac caa gac gag cca aat 835
Arg Ile Pro Glu Thr Pro Ala Phe Glu Asn Asn Gln Asp Glu Pro Asn
230 235 240 245
gca gtt gtt gaa aag gac act gaa gat cct tat gca cgc ctg ggc ctg 883
Ala Val Val Glu Lys Asp Thr Glu Asp Pro Tyr Ala Arg Leu Gly Leu
250 255 260
gct ggt gtt atc cgc cac cac tgg cgt cca ctg ctg att ggt att gcg 931
Ala Gly Val Ile Arg His His Trp Arg Pro Leu Leu Ile Gly Ile Ala
265 270 275
att gtg gca gcg acc aac acc gcc ggt tac gcg cta acc agt tac atg 979
Ile Val Ala Ala Thr Asn Thr Ala Gly Tyr Ala Leu Thr Ser Tyr Met
280 285 290
cct gtg tat cta gag gag cag atc ggt ctg cac tcc gca tcc gct gcc 1027
Pro Val Tyr Leu Glu Glu Gln Ile Gly Leu His Ser Ala Ser Ala Ala
295 300 305
gct gtg acc gtg ccg att ctg gtt gtt atg tcc ctg ctg ctg cca ttt 1075
Ala Val Thr Val Pro Ile Leu Val Val Met Ser Leu Leu Leu Pro Phe
310 315 320 325
gtt ggt atg tgg agt gac cgc gtg ggc cgc aag cct gtc tac gcg act 1123
Val Gly Met Trp Ser Asp Arg Val Gly Arg Lys Pro Val Tyr Ala Thr
330 335 340
gct gtt gcg gca acg ctg atc ttg atg gtt cct gcc ttc ttg atc atg 1171
Ala Val Ala Ala Thr Leu Ile Leu Met Val Pro Ala Phe Leu Ile Met
345 350 355
aac acc gga acc atc ggc gcc gta ctg att gca ctg tcc atg gtt gct 1219
Asn Thr Gly Thr Ile Gly Ala Val Leu Ile Ala Leu Ser Met Val Ala
360 365 370
att cca acc ggt ttg tat gtg gca ctg tcc gca tct gcc ctg cca gcg 1267
Ile Pro Thr Gly Leu Tyr Val Ala Leu Ser Ala Ser Ala Leu Pro Ala
375 380 385
ctg ttc cca acc gcg tca cga ttc tct gga atg ggt att tcc tac aac 1315
Leu Phe Pro Thr Ala Ser Arg Phe Ser Gly Met Gly Ile Ser Tyr Asn
390 395 400 405
att tcc gtg tcg ttg ttc ggt ggt aca acc ccg ctg atc acc cag ttc 1363
Ile Ser Val Ser Leu Phe Gly Gly Thr Thr Pro Leu Ile Thr Gln Phe
410 415 420
ctg ctg cag aag act ggc ctg gat atc gtt cca gcg ctc tac atc atg 1411
Leu Leu Gln Lys Thr Gly Leu Asp Ile Val Pro Ala Leu Tyr Ile Met
425 430 435
ttc ttc tct gca atc gca ggt gtg gcg ctg ctg ttc atg acc gag tct 1459
Phe Phe Ser Ala Ile Ala Gly Val Ala Leu Leu Phe Met Thr Glu Ser
440 445 450
tca cag aag cca ctg ctt ggc tca ttc cca acc gtg gaa acc aag tct 1507
Ser Gln Lys Pro Leu Leu Gly Ser Phe Pro Thr Val Glu Thr Lys Ser
455 460 465
gag gcc gtg gag atc gtg aag aac cag gac gag gat cca aat att gat 1555
Glu Ala Val Glu Ile Val Lys Asn Gln Asp Glu Asp Pro Asn Ile Asp
470 475 480 485
ctt tcc cat atg ccg ttt cct gat gag gaa aac gta ggt gct gaa aag 1603
Leu Ser His Met Pro Phe Pro Asp Glu Glu Asn Val Gly Ala Glu Lys
490 495 500
caa aac gca taaccgtaaa gcccgctgca agg 1635
Gln Asn Ala
<210> 500
<211> 504
<212> PRT
<213> Corynebacterium glutamicum
<400> 500
Val Ser Pro Ile Arg Ser Lys Lys Lys Ile Lys Asn Glu Pro Arg Leu
1 5 10 15
Thr Val Asp Asp Val Asn Val Val Pro Pro Lys Lys Ile Arg Pro Ala
20 25 30
Ile Lys Gly Thr Val Val Gly Asn Phe Met Glu Trp Tyr Asp Phe Gly
35 40 45
Ile Tyr Gly Tyr Leu Thr Val Thr Met Thr Ala Val Phe Thr Gln Gly
50 55 60
Leu Pro Gln Glu Trp Gln Leu Leu Ala Val Met Phe Gly Phe Ala Val
65 70 75 80
Ser Tyr Leu Val Arg Pro Leu Gly Gly Leu Val Leu Gly Pro Leu Gly
85 90 95
Asp Lys Val Gly Arg Gln Lys Val Leu Tyr Val Thr Met Ala Met Met
100 105 110
Ala Val Ser Thr Ala Leu Ile Gly Leu Leu Pro Thr Ala Ala Ser Ile
115 120 125
Gly Ala Trp Ala Leu Val Leu Leu Tyr Leu Leu Lys Met Val Gln Gly
130 135 140
Phe Ser Thr Gly Gly Glu Tyr Ala Gly Ala Thr Thr Tyr Val Ala Glu
145 150 155 160
Phe Ala Pro Asp Arg Arg Arg Gly Phe Phe Gly Ala Phe Leu Asp Met
165 170 175
Gly Ser Tyr Leu Gly Phe Ala Ala Gly Ala Ser Val Val Ala Ile Thr
180 185 190
Thr Trp Val Thr Thr His Phe Tyr Gly Ala Thr Ala Met Glu Asp Phe
195 200 205
Gly Trp Arg Ile Pro Phe Leu Thr Ala Ile Pro Leu Gly Ile Ile Ala
210 215 220
Val Tyr Leu Arg Thr Arg Ile Pro Glu Thr Pro Ala Phe Glu Asn Asn
225 230 235 240
Gln Asp Glu Pro Asn Ala Val Val Glu Lys Asp Thr Glu Asp Pro Tyr
245 250 255
Ala Arg Leu Gly Leu Ala Gly Val Ile Arg His His Trp Arg Pro Leu
260 265 270
Leu Ile Gly Ile Ala Ile Val Ala Ala Thr Asn Thr Ala Gly Tyr Ala
275 280 285
Leu Thr Ser Tyr Met Pro Val Tyr Leu Glu Glu Gln Ile Gly Leu His
290 295 300
Ser Ala Ser Ala Ala Ala Val Thr Val Pro Ile Leu Val Val Met Ser
305 310 315 320
Leu Leu Leu Pro Phe Val Gly Met Trp Ser Asp Arg Val Gly Arg Lys
325 330 335
Pro Val Tyr Ala Thr Ala Val Ala Ala Thr Leu Ile Leu Met Val Pro
340 345 350
Ala Phe Leu Ile Met Asn Thr Gly Thr Ile Gly Ala Val Leu Ile Ala
355 360 365
Leu Ser Met Val Ala Ile Pro Thr Gly Leu Tyr Val Ala Leu Ser Ala
370 375 380
Ser Ala Leu Pro Ala Leu Phe Pro Thr Ala Ser Arg Phe Ser Gly Met
385 390 395 400
Gly Ile Ser Tyr Asn Ile Ser Val Ser Leu Phe Gly Gly Thr Thr Pro
405 410 415
Leu Ile Thr Gln Phe Leu Leu Gln Lys Thr Gly Leu Asp Ile Val Pro
420 425 430
Ala Leu Tyr Ile Met Phe Phe Ser Ala Ile Ala Gly Val Ala Leu Leu
435 440 445
Phe Met Thr Glu Ser Ser Gln Lys Pro Leu Leu Gly Ser Phe Pro Thr
450 455 460
Val Glu Thr Lys Ser Glu Ala Val Glu Ile Val Lys Asn Gln Asp Glu
465 470 475 480
Asp Pro Asn Ile Asp Leu Ser His Met Pro Phe Pro Asp Glu Glu Asn
485 490 495
Val Gly Ala Glu Lys Gln Asn Ala
500
<210> 501
<211> 1509
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1486)
<223> RXA02030
<400> 501
gcgcctaaca tctcattgta tgggattgac tctaataatc tcctgtggaa acatcgcaag 60
ggtaattatt ggaatctatt attgtgtgag gcgataactc gtg acc aca act gat 115
Val Thr Thr Thr Asp
1 5
cac tcc acg gag ttg aat cct tct gat cca ggt ggg cag acg gca acc 163
His Ser Thr Glu Leu Asn Pro Ser Asp Pro Gly Gly Gln Thr Ala Thr
10 15 20
cta gtg att gac aag aaa act aaa cgt cgg gtt gca gca gcc tcc acc 211
Leu Val Ile Asp Lys Lys Thr Lys Arg Arg Val Ala Ala Ala Ser Thr
25 30 35
atc ggc aca acc atc gag ttc tac gat ttt tat gcg tac gct gcg gca 259
Ile Gly Thr Thr Ile Glu Phe Tyr Asp Phe Tyr Ala Tyr Ala Ala Ala
40 45 50
gct gtc gtt gtt ttc cca agt ctg ttt ttc cct gcc aat gac aac cca 307
Ala Val Val Val Phe Pro Ser Leu Phe Phe Pro Ala Asn Asp Asn Pro
55 60 65
acc gtg aac ctg ttg gca tcg ttt gcc acc ttt ggt ctt gcg ttc gtt 355
Thr Val Asn Leu Leu Ala Ser Phe Ala Thr Phe Gly Leu Ala Phe Val
70 75 80 85
gct cgt cca ctc ggt tca atc att ttc ggg cac ttc ggt gac cgt gtg 403
Ala Arg Pro Leu Gly Ser Ile Ile Phe Gly His Phe Gly Asp Arg Val
90 95 100
gga cgc aaa gct acc ttg atc ggt tca ctg ctg acc atg ggc att gcc 451
Gly Arg Lys Ala Thr Leu Ile Gly Ser Leu Leu Thr Met Gly Ile Ala
105 110 115
acc atc ttg atc ggc ctg ctg cct act tat ggt cag gtc gga atc att 499
Thr Ile Leu Ile Gly Leu Leu Pro Thr Tyr Gly Gln Val Gly Ile Ile
120 125 130
gca ccg gcg ctg ttg gcg ctc atg cgt ttc tgc cag ggc ctg ggc ctt 547
Ala Pro Ala Leu Leu Ala Leu Met Arg Phe Cys Gln Gly Leu Gly Leu
135 140 145
ggc ggt gaa tgg tct ggc gct gcg ttg ctg gct ggt gaa aac gcg gaa 595
Gly Gly Glu Trp Ser Gly Ala Ala Leu Leu Ala Gly Glu Asn Ala Glu
150 155 160 165
aac act cac cgc gct cgt gct gca atg tgg cca cag ctg ggt gca ccg 643
Asn Thr His Arg Ala Arg Ala Ala Met Trp Pro Gln Leu Gly Ala Pro
170 175 180
ttt ggt ttc ttc ttg gcc aat ggt ttc atg ctc att ctg gtc ggt gtg 691
Phe Gly Phe Phe Leu Ala Asn Gly Phe Met Leu Ile Leu Val Gly Val
185 190 195
ctt gcc cat cag gac ggc gat ctt cac ggc gcg ttc atg acc tgg ggt 739
Leu Ala His Gln Asp Gly Asp Leu His Gly Ala Phe Met Thr Trp Gly
200 205 210
tgg cgt ctg cca ttc ctg tct tcg gcg atc atg atc gca gtt ggc ctg 787
Trp Arg Leu Pro Phe Leu Ser Ser Ala Ile Met Ile Ala Val Gly Leu
215 220 225
tgg gtg cgt ttc tca ctg gag gaa act cca gtg ttc aag cag gct gtt 835
Trp Val Arg Phe Ser Leu Glu Glu Thr Pro Val Phe Lys Gln Ala Val
230 235 240 245
gat cag ggc aag aag gtg aag tct ccg ctc aag gag ctg ttc aag act 883
Asp Gln Gly Lys Lys Val Lys Ser Pro Leu Lys Glu Leu Phe Lys Thr
250 255 260
tcc cct ggc cct gtt gtg cag gct act ttg atc atg ctg tcc act tat 931
Ser Pro Gly Pro Val Val Gln Ala Thr Leu Ile Met Leu Ser Thr Tyr
265 270 275
acc ttg ttc tac ctg gtt acc acg tgg att ctg tcg tat ggc atc ggt 979
Thr Leu Phe Tyr Leu Val Thr Thr Trp Ile Leu Ser Tyr Gly Ile Gly
280 285 290
aat cgc agc acc gga aac ggc ctg tct att ccg tac ttt gag ttc ttg 1027
Asn Arg Ser Thr Gly Asn Gly Leu Ser Ile Pro Tyr Phe Glu Phe Leu
295 300 305
cag ttg cag ctg gcc acc atc gtg ttc ttc gcc atc atg atc cct gtg 1075
Gln Leu Gln Leu Ala Thr Ile Val Phe Phe Ala Ile Met Ile Pro Val
310 315 320 325
tca ggc tgg ttg gct gat gtg tgg ggt cgt aaa aac acc ctg acc ttg 1123
Ser Gly Trp Leu Ala Asp Val Trp Gly Arg Lys Asn Thr Leu Thr Leu
330 335 340
gct tct gtg ctg ctt ctc ggc ttt ggt ctg acg ttt aat ctg ctt ctc 1171
Ala Ser Val Leu Leu Leu Gly Phe Gly Leu Thr Phe Asn Leu Leu Leu
345 350 355
gat cca gag acc gcc acc aag acc acc gtg ttc atc ttc ttg ttc gtg 1219
Asp Pro Glu Thr Ala Thr Lys Thr Thr Val Phe Ile Phe Leu Phe Val
360 365 370
ggc atg agc atc atg ggt ctg atc ttt gga ccc atg tcg gca att ttg 1267
Gly Met Ser Ile Met Gly Leu Ile Phe Gly Pro Met Ser Ala Ile Leu
375 380 385
ccg gag ctc ttc ccc acc aac gtc cgc tac acg ggc tcc gga atc gcc 1315
Pro Glu Leu Phe Pro Thr Asn Val Arg Tyr Thr Gly Ser Gly Ile Ala
390 395 400 405
tac aat gtc tcc tcg atc ctc ggt gca gct att gca ccg ttc atc gca 1363
Tyr Asn Val Ser Ser Ile Leu Gly Ala Ala Ile Ala Pro Phe Ile Ala
410 415 420
acg tgg ctg gtg tcc gag ttt tca gtg gcg tac gtc ggc tat tac ctc 1411
Thr Trp Leu Val Ser Glu Phe Ser Val Ala Tyr Val Gly Tyr Tyr Leu
425 430 435
atc atc gtc acc gca att acc ttt gtt gcg gtg ctg acg atg aag gaa 1459
Ile Ile Val Thr Ala Ile Thr Phe Val Ala Val Leu Thr Met Lys Glu
440 445 450
aac aaa aac cac gac ctc cga gag gtc taaaagattt ttgcttatcg 1506
Asn Lys Asn His Asp Leu Arg Glu Val
455 460
acg 1509
<210> 502
<211> 462
<212> PRT
<213> Corynebacterium glutamicum
<400> 502
Val Thr Thr Thr Asp His Ser Thr Glu Leu Asn Pro Ser Asp Pro Gly
1 5 10 15
Gly Gln Thr Ala Thr Leu Val Ile Asp Lys Lys Thr Lys Arg Arg Val
20 25 30
Ala Ala Ala Ser Thr Ile Gly Thr Thr Ile Glu Phe Tyr Asp Phe Tyr
35 40 45
Ala Tyr Ala Ala Ala Ala Val Val Val Phe Pro Ser Leu Phe Phe Pro
50 55 60
Ala Asn Asp Asn Pro Thr Val Asn Leu Leu Ala Ser Phe Ala Thr Phe
65 70 75 80
Gly Leu Ala Phe Val Ala Arg Pro Leu Gly Ser Ile Ile Phe Gly His
85 90 95
Phe Gly Asp Arg Val Gly Arg Lys Ala Thr Leu Ile Gly Ser Leu Leu
100 105 110
Thr Met Gly Ile Ala Thr Ile Leu Ile Gly Leu Leu Pro Thr Tyr Gly
115 120 125
Gln Val Gly Ile Ile Ala Pro Ala Leu Leu Ala Leu Met Arg Phe Cys
130 135 140
Gln Gly Leu Gly Leu Gly Gly Glu Trp Ser Gly Ala Ala Leu Leu Ala
145 150 155 160
Gly Glu Asn Ala Glu Asn Thr His Arg Ala Arg Ala Ala Met Trp Pro
165 170 175
Gln Leu Gly Ala Pro Phe Gly Phe Phe Leu Ala Asn Gly Phe Met Leu
180 185 190
Ile Leu Val Gly Val Leu Ala His Gln Asp Gly Asp Leu His Gly Ala
195 200 205
Phe Met Thr Trp Gly Trp Arg Leu Pro Phe Leu Ser Ser Ala Ile Met
210 215 220
Ile Ala Val Gly Leu Trp Val Arg Phe Ser Leu Glu Glu Thr Pro Val
225 230 235 240
Phe Lys Gln Ala Val Asp Gln Gly Lys Lys Val Lys Ser Pro Leu Lys
245 250 255
Glu Leu Phe Lys Thr Ser Pro Gly Pro Val Val Gln Ala Thr Leu Ile
260 265 270
Met Leu Ser Thr Tyr Thr Leu Phe Tyr Leu Val Thr Thr Trp Ile Leu
275 280 285
Ser Tyr Gly Ile Gly Asn Arg Ser Thr Gly Asn Gly Leu Ser Ile Pro
290 295 300
Tyr Phe Glu Phe Leu Gln Leu Gln Leu Ala Thr Ile Val Phe Phe Ala
305 310 315 320
Ile Met Ile Pro Val Ser Gly Trp Leu Ala Asp Val Trp Gly Arg Lys
325 330 335
Asn Thr Leu Thr Leu Ala Ser Val Leu Leu Leu Gly Phe Gly Leu Thr
340 345 350
Phe Asn Leu Leu Leu Asp Pro Glu Thr Ala Thr Lys Thr Thr Val Phe
355 360 365
Ile Phe Leu Phe Val Gly Met Ser Ile Met Gly Leu Ile Phe Gly Pro
370 375 380
Met Ser Ala Ile Leu Pro Glu Leu Phe Pro Thr Asn Val Arg Tyr Thr
385 390 395 400
Gly Ser Gly Ile Ala Tyr Asn Val Ser Ser Ile Leu Gly Ala Ala Ile
405 410 415
Ala Pro Phe Ile Ala Thr Trp Leu Val Ser Glu Phe Ser Val Ala Tyr
420 425 430
Val Gly Tyr Tyr Leu Ile Ile Val Thr Ala Ile Thr Phe Val Ala Val
435 440 445
Leu Thr Met Lys Glu Asn Lys Asn His Asp Leu Arg Glu Val
450 455 460
<210> 503
<211> 870
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(847)
<223> RXA00186
<400> 503
agaagcccag cattttgttt agctcacctc taaagctcct gatctggata cgaggactcc 60
tgcggaaaac cgtgtggcta gtgaagctac ccggcatctc atg ggg gag aag act 115
Met Gly Glu Lys Thr
1 5
tct gtc gcg tat gtt cac gat gtt ctg atc aag ggc gtg cca gtg cgg 163
Ser Val Ala Tyr Val His Asp Val Leu Ile Lys Gly Val Pro Val Arg
10 15 20
ata tac aat ccg cac ccc aac gac ggg ccg ctt cct gtc ttt atc tac 211
Ile Tyr Asn Pro His Pro Asn Asp Gly Pro Leu Pro Val Phe Ile Tyr
25 30 35
ttc cat ggt ggc gga tgg gtt ttg ggg gac ctt gaa tca gtg gat tcc 259
Phe His Gly Gly Gly Trp Val Leu Gly Asp Leu Glu Ser Val Asp Ser
40 45 50
acc gtg cgc gat att gcc gtt gct tca ggc gcc ctg tgt atc agt gtg 307
Thr Val Arg Asp Ile Ala Val Ala Ser Gly Ala Leu Cys Ile Ser Val
55 60 65
gat tat cgc cgt gca ccg gaa cat cct ttt ctc gct gca ttg gat gat 355
Asp Tyr Arg Arg Ala Pro Glu His Pro Phe Leu Ala Ala Leu Asp Asp
70 75 80 85
tgc caa gtg gtc acg gaa gct gtc ctc aat ggt gaa ctc gcc agt gct 403
Cys Gln Val Val Thr Glu Ala Val Leu Asn Gly Glu Leu Ala Ser Ala
90 95 100
aac cag cat cta gtg gca gtc ggc ggg gac agc gcc ggt ggc aat att 451
Asn Gln His Leu Val Ala Val Gly Gly Asp Ser Ala Gly Gly Asn Ile
105 110 115
gcg gcg gtc atc gct caa cag ctg cgc gat cag atc acc cac caa gtt 499
Ala Ala Val Ile Ala Gln Gln Leu Arg Asp Gln Ile Thr His Gln Val
120 125 130
ctt gtg tat ccg gtg atg gac gta atc ttg ctg gtg att tgt tct atc 547
Leu Val Tyr Pro Val Met Asp Val Ile Leu Leu Val Ile Cys Ser Ile
135 140 145
att acc act ggt ttt gcg ctg ctc atg cat cca aag agc aag gac aag 595
Ile Thr Thr Gly Phe Ala Leu Leu Met His Pro Lys Ser Lys Asp Lys
150 155 160 165
acg gag acg att tct gat gaa ttc ctc gca gag atc caa gcg gga agt 643
Thr Glu Thr Ile Ser Asp Glu Phe Leu Ala Glu Ile Gln Ala Gly Ser
170 175 180
gaa aag atc tcc att ctg cgt tcg acc cct gct gaa aaa gcc aat gcg 691
Glu Lys Ile Ser Ile Leu Arg Ser Thr Pro Ala Glu Lys Ala Asn Ala
185 190 195
agc cgt tgg atc atg tac ttc gtt ggc gga att ggc ctg ctc tac agc 739
Ser Arg Trp Ile Met Tyr Phe Val Gly Gly Ile Gly Leu Leu Tyr Ser
200 205 210
gtg ttc agc ctg tgg aca ggt ggc gta acc gga ctg acg ttg aac tcc 787
Val Phe Ser Leu Trp Thr Gly Gly Val Thr Gly Leu Thr Leu Asn Ser
215 220 225
ttc aac ttc ctg ttc ctg tca ctc ggc atg gtg ctc acc gct aat tac 835
Phe Asn Phe Leu Phe Leu Ser Leu Gly Met Val Leu Thr Ala Asn Tyr
230 235 240 245
ggg cca gag tat taagcaaagc ttattcgcga agg 870
Gly Pro Glu Tyr
<210> 504
<211> 249
<212> PRT
<213> Corynebacterium glutamicum
<400> 504
Met Gly Glu Lys Thr Ser Val Ala Tyr Val His Asp Val Leu Ile Lys
1 5 10 15
Gly Val Pro Val Arg Ile Tyr Asn Pro His Pro Asn Asp Gly Pro Leu
20 25 30
Pro Val Phe Ile Tyr Phe His Gly Gly Gly Trp Val Leu Gly Asp Leu
35 40 45
Glu Ser Val Asp Ser Thr Val Arg Asp Ile Ala Val Ala Ser Gly Ala
50 55 60
Leu Cys Ile Ser Val Asp Tyr Arg Arg Ala Pro Glu His Pro Phe Leu
65 70 75 80
Ala Ala Leu Asp Asp Cys Gln Val Val Thr Glu Ala Val Leu Asn Gly
85 90 95
Glu Leu Ala Ser Ala Asn Gln His Leu Val Ala Val Gly Gly Asp Ser
100 105 110
Ala Gly Gly Asn Ile Ala Ala Val Ile Ala Gln Gln Leu Arg Asp Gln
115 120 125
Ile Thr His Gln Val Leu Val Tyr Pro Val Met Asp Val Ile Leu Leu
130 135 140
Val Ile Cys Ser Ile Ile Thr Thr Gly Phe Ala Leu Leu Met His Pro
145 150 155 160
Lys Ser Lys Asp Lys Thr Glu Thr Ile Ser Asp Glu Phe Leu Ala Glu
165 170 175
Ile Gln Ala Gly Ser Glu Lys Ile Ser Ile Leu Arg Ser Thr Pro Ala
180 185 190
Glu Lys Ala Asn Ala Ser Arg Trp Ile Met Tyr Phe Val Gly Gly Ile
195 200 205
Gly Leu Leu Tyr Ser Val Phe Ser Leu Trp Thr Gly Gly Val Thr Gly
210 215 220
Leu Thr Leu Asn Ser Phe Asn Phe Leu Phe Leu Ser Leu Gly Met Val
225 230 235 240
Leu Thr Ala Asn Tyr Gly Pro Glu Tyr
245
<210> 505
<211> 468
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(451)
<223> RXA00187
<400> 505
gcttattcgc gaaggcatcc aaggaacgtg gggattcatt cttcaattcc cgttctacgc 60
aggcattttc gggttgattt ccttcaccgg tctgggtgtt gtg atc tcc gga ttt 115
Val Ile Ser Gly Phe
1 5
ttc acc tcg att tcc acg gca acc acg tgg cct gtc atc gcg ttc ctc 163
Phe Thr Ser Ile Ser Thr Ala Thr Thr Trp Pro Val Ile Ala Phe Leu
10 15 20
tac tct gga ctg ctc aac atc gcg gtg cct tca ggt ggc tcg aaa ttc 211
Tyr Ser Gly Leu Leu Asn Ile Ala Val Pro Ser Gly Gly Ser Lys Phe
25 30 35
atc atc gaa gcc ccg tac atc atc cca acc cca gtg gat ctt ggc gct 259
Ile Ile Glu Ala Pro Tyr Ile Ile Pro Thr Pro Val Asp Leu Gly Ala
40 45 50
gac atg ggc ctt gtc ctg cag gct tat caa atg agt gat ggc gcg acc 307
Asp Met Gly Leu Val Leu Gln Ala Tyr Gln Met Ser Asp Gly Ala Thr
55 60 65
aac ctg ctc att ccg ttc ttc gcg ctg cca tat ttg gcc aat ttc aag 355
Asn Leu Leu Ile Pro Phe Phe Ala Leu Pro Tyr Leu Ala Asn Phe Lys
70 75 80 85
atc aaa ttc agc caa gtg gtg ggc tat aca gtt ccg cct gtc ctc gtt 403
Ile Lys Phe Ser Gln Val Val Gly Tyr Thr Val Pro Pro Val Leu Val
90 95 100
gtt atc gcc gtg atc tgc att tac ctg ttc ctg cga gca tca atc att 451
Val Ile Ala Val Ile Cys Ile Tyr Leu Phe Leu Arg Ala Ser Ile Ile
105 110 115
taaaaagatg cttctcg 468
<210> 506
<211> 117
<212> PRT
<213> Corynebacterium glutamicum
<400> 506
Val Ile Ser Gly Phe Phe Thr Ser Ile Ser Thr Ala Thr Thr Trp Pro
1 5 10 15
Val Ile Ala Phe Leu Tyr Ser Gly Leu Leu Asn Ile Ala Val Pro Ser
20 25 30
Gly Gly Ser Lys Phe Ile Ile Glu Ala Pro Tyr Ile Ile Pro Thr Pro
35 40 45
Val Asp Leu Gly Ala Asp Met Gly Leu Val Leu Gln Ala Tyr Gln Met
50 55 60
Ser Asp Gly Ala Thr Asn Leu Leu Ile Pro Phe Phe Ala Leu Pro Tyr
65 70 75 80
Leu Ala Asn Phe Lys Ile Lys Phe Ser Gln Val Val Gly Tyr Thr Val
85 90 95
Pro Pro Val Leu Val Val Ile Ala Val Ile Cys Ile Tyr Leu Phe Leu
100 105 110
Arg Ala Ser Ile Ile
115
<210> 507
<211> 1329
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1306)
<223> RXA01667
<400> 507
tctcggcgtt gatgatcatc cgcaatatca tgccgccgca agattccgct tttccagact 60
ttgctcattc cttcctctat tactgctcgc catcatcggc atg att ttg ggg cct 115
Met Ile Leu Gly Pro
1 5
aag gtg ttg ggt ctg att ggt tgg tcg gat cat ctt tcc act tac act 163
Lys Val Leu Gly Leu Ile Gly Trp Ser Asp His Leu Ser Thr Tyr Thr
10 15 20
acg gtg ctc att gcg att gtg ttt gct tcg atg ccg tat tcg atg aag 211
Thr Val Leu Ile Ala Ile Val Phe Ala Ser Met Pro Tyr Ser Met Lys
25 30 35
ttt gac cgt ggc gtg cgt act ggc atg aag acg atg tgg gcg tat tcg 259
Phe Asp Arg Gly Val Arg Thr Gly Met Lys Thr Met Trp Ala Tyr Ser
40 45 50
act gcg atg ttt gtg ggg cag tgg ggt ctg ttc att ttg ctg ggt ctg 307
Thr Ala Met Phe Val Gly Gln Trp Gly Leu Phe Ile Leu Leu Gly Leu
55 60 65
ttt ttg ttc caa ccg gtg tgg ggt acc gat gag tgg ttc ggc atg atg 355
Phe Leu Phe Gln Pro Val Trp Gly Thr Asp Glu Trp Phe Gly Met Met
70 75 80 85
ttg ccg gtt ggt ttt gtt ggt ggt ttt ggt act gct gct gcg gtg ggt 403
Leu Pro Val Gly Phe Val Gly Gly Phe Gly Thr Ala Ala Ala Val Gly
90 95 100
act gcg ttg gag tct tcg ggt gcg gag gct gcg atg tct ttg ggc ttt 451
Thr Ala Leu Glu Ser Ser Gly Ala Glu Ala Ala Met Ser Leu Gly Phe
105 110 115
acc tct gcg acg gtg ggt act ttt gct gcg att gtt ggt gga att att 499
Thr Ser Ala Thr Val Gly Thr Phe Ala Ala Ile Val Gly Gly Ile Ile
120 125 130
ttc aca acg tgg ggt att aag aag ggc aag act gcg gcg atg cct gcg 547
Phe Thr Thr Trp Gly Ile Lys Lys Gly Lys Thr Ala Ala Met Pro Ala
135 140 145
cag ttg ccg tgg gat ttg cgt tcg ggt tat atc gat aag ctg agt gat 595
Gln Leu Pro Trp Asp Leu Arg Ser Gly Tyr Ile Asp Lys Leu Ser Asp
150 155 160 165
cgt ccg tcg att ggt aag gcg agt acg aat ccg tct gcg att gag cct 643
Arg Pro Ser Ile Gly Lys Ala Ser Thr Asn Pro Ser Ala Ile Glu Pro
170 175 180
ttg gcg ctg cat act ggc att att ttg ttg act gtt gcg gtt gcg tat 691
Leu Ala Leu His Thr Gly Ile Ile Leu Leu Thr Val Ala Val Ala Tyr
185 190 195
tcc att aat cag tgg ttg ggt agc atg ttc cca acc gtg cag att ccg 739
Ser Ile Asn Gln Trp Leu Gly Ser Met Phe Pro Thr Val Gln Ile Pro
200 205 210
ttg ttt gcg atg tca ttt gtg gtc ggc att gtg ggc atg gga att atg 787
Leu Phe Ala Met Ser Phe Val Val Gly Ile Val Gly Met Gly Ile Met
215 220 225
cgt ttg ttg aag aag cct gag tat ttg gat cgc gac acc gtg aat tcc 835
Arg Leu Leu Lys Lys Pro Glu Tyr Leu Asp Arg Asp Thr Val Asn Ser
230 235 240 245
gtg tcg ggc gcg gcg acg gat tac ctc att gcg ttt ggt att gcc tcg 883
Val Ser Gly Ala Ala Thr Asp Tyr Leu Ile Ala Phe Gly Ile Ala Ser
250 255 260
att gct cct gct gcg att gct gat tac tgg gtt cct ctt gtg gtg ctg 931
Ile Ala Pro Ala Ala Ile Ala Asp Tyr Trp Val Pro Leu Val Val Leu
265 270 275
ttt gtt ttg ggc acc atc aac tgt tgt ttc ttc ttt ttc tgg gtt gcg 979
Phe Val Leu Gly Thr Ile Asn Cys Cys Phe Phe Phe Phe Trp Val Ala
280 285 290
cct cgt ttc ttt ggc gag aag tgg ctg gag cgc gcg atc ttc ggt tgg 1027
Pro Arg Phe Phe Gly Glu Lys Trp Leu Glu Arg Ala Ile Phe Gly Trp
295 300 305
ggt tgg gct act gcc gcg gtt gct acc ggt atc gcg ttg ctg aag atc 1075
Gly Trp Ala Thr Ala Ala Val Ala Thr Gly Ile Ala Leu Leu Lys Ile
310 315 320 325
gtg gat ccg aag ttg aag tcg gga gcg ctt aat gag tac ggc gtg gct 1123
Val Asp Pro Lys Leu Lys Ser Gly Ala Leu Asn Glu Tyr Gly Val Ala
330 335 340
tat atc ggt ttt gct cca ttt gaa atc ggc atg acc atc atc gcg ccg 1171
Tyr Ile Gly Phe Ala Pro Phe Glu Ile Gly Met Thr Ile Ile Ala Pro
345 350 355
atc gcg gtg ctc gca ggc ttt acc atg ggg ttg ggt tgg gcg tcg ttg 1219
Ile Ala Val Leu Ala Gly Phe Thr Met Gly Leu Gly Trp Ala Ser Leu
360 365 370
att gtt gcg atc gtg att ttt ggc ctc gcg tgg ggt ctg aag tgg ttg 1267
Ile Val Ala Ile Val Ile Phe Gly Leu Ala Trp Gly Leu Lys Trp Leu
375 380 385
ccg gag cgc gga cat gtc cgc ggc gag ggt aag ccg caa taaaggttgg 1316
Pro Glu Arg Gly His Val Arg Gly Glu Gly Lys Pro Gln
390 395 400
aagcgccggg tct 1329
<210> 508
<211> 402
<212> PRT
<213> Corynebacterium glutamicum
<400> 508
Met Ile Leu Gly Pro Lys Val Leu Gly Leu Ile Gly Trp Ser Asp His
1 5 10 15
Leu Ser Thr Tyr Thr Thr Val Leu Ile Ala Ile Val Phe Ala Ser Met
20 25 30
Pro Tyr Ser Met Lys Phe Asp Arg Gly Val Arg Thr Gly Met Lys Thr
35 40 45
Met Trp Ala Tyr Ser Thr Ala Met Phe Val Gly Gln Trp Gly Leu Phe
50 55 60
Ile Leu Leu Gly Leu Phe Leu Phe Gln Pro Val Trp Gly Thr Asp Glu
65 70 75 80
Trp Phe Gly Met Met Leu Pro Val Gly Phe Val Gly Gly Phe Gly Thr
85 90 95
Ala Ala Ala Val Gly Thr Ala Leu Glu Ser Ser Gly Ala Glu Ala Ala
100 105 110
Met Ser Leu Gly Phe Thr Ser Ala Thr Val Gly Thr Phe Ala Ala Ile
115 120 125
Val Gly Gly Ile Ile Phe Thr Thr Trp Gly Ile Lys Lys Gly Lys Thr
130 135 140
Ala Ala Met Pro Ala Gln Leu Pro Trp Asp Leu Arg Ser Gly Tyr Ile
145 150 155 160
Asp Lys Leu Ser Asp Arg Pro Ser Ile Gly Lys Ala Ser Thr Asn Pro
165 170 175
Ser Ala Ile Glu Pro Leu Ala Leu His Thr Gly Ile Ile Leu Leu Thr
180 185 190
Val Ala Val Ala Tyr Ser Ile Asn Gln Trp Leu Gly Ser Met Phe Pro
195 200 205
Thr Val Gln Ile Pro Leu Phe Ala Met Ser Phe Val Val Gly Ile Val
210 215 220
Gly Met Gly Ile Met Arg Leu Leu Lys Lys Pro Glu Tyr Leu Asp Arg
225 230 235 240
Asp Thr Val Asn Ser Val Ser Gly Ala Ala Thr Asp Tyr Leu Ile Ala
245 250 255
Phe Gly Ile Ala Ser Ile Ala Pro Ala Ala Ile Ala Asp Tyr Trp Val
260 265 270
Pro Leu Val Val Leu Phe Val Leu Gly Thr Ile Asn Cys Cys Phe Phe
275 280 285
Phe Phe Trp Val Ala Pro Arg Phe Phe Gly Glu Lys Trp Leu Glu Arg
290 295 300
Ala Ile Phe Gly Trp Gly Trp Ala Thr Ala Ala Val Ala Thr Gly Ile
305 310 315 320
Ala Leu Leu Lys Ile Val Asp Pro Lys Leu Lys Ser Gly Ala Leu Asn
325 330 335
Glu Tyr Gly Val Ala Tyr Ile Gly Phe Ala Pro Phe Glu Ile Gly Met
340 345 350
Thr Ile Ile Ala Pro Ile Ala Val Leu Ala Gly Phe Thr Met Gly Leu
355 360 365
Gly Trp Ala Ser Leu Ile Val Ala Ile Val Ile Phe Gly Leu Ala Trp
370 375 380
Gly Leu Lys Trp Leu Pro Glu Arg Gly His Val Arg Gly Glu Gly Lys
385 390 395 400
Pro Gln
<210> 509
<211> 1776
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1753)
<223> RXA02171
<400> 509
aaccacattc gtcattactt acatctatgt catgtttgcg aacaagaact tggagcctcg 60
tcaggctgct attcgccaga agatggaagg ttaatcagat atg aat tcc act att 115
Met Asn Ser Thr Ile
1 5
ctc ctt gca caa gac gct gtt tct gag ggc gtc ggt aat ccg att ctt 163
Leu Leu Ala Gln Asp Ala Val Ser Glu Gly Val Gly Asn Pro Ile Leu
10 15 20
aac atc agt gtc ttc gtc gtc ttc att att gtg acg atg acc gtg gtg 211
Asn Ile Ser Val Phe Val Val Phe Ile Ile Val Thr Met Thr Val Val
25 30 35
ctt cgc gtg ggc aag agc acc agc gaa tcc acc gac ttc tac acc ggt 259
Leu Arg Val Gly Lys Ser Thr Ser Glu Ser Thr Asp Phe Tyr Thr Gly
40 45 50
ggt gct tcc ttc tcc gga acc cag aac ggt ctg gct atc gca ggt gac 307
Gly Ala Ser Phe Ser Gly Thr Gln Asn Gly Leu Ala Ile Ala Gly Asp
55 60 65
tac ctg tct gca gcg tcc ttc ctc gga atc gtt ggt gca att tca ctc 355
Tyr Leu Ser Ala Ala Ser Phe Leu Gly Ile Val Gly Ala Ile Ser Leu
70 75 80 85
aac ggt tac gac gga ttc ctt tac tcc atc ggc ttc ttc gtc gca tgg 403
Asn Gly Tyr Asp Gly Phe Leu Tyr Ser Ile Gly Phe Phe Val Ala Trp
90 95 100
ctt gtt gca ctg ctg ctc gtg gca gag cca ctt cgt aac gtg ggc cgc 451
Leu Val Ala Leu Leu Leu Val Ala Glu Pro Leu Arg Asn Val Gly Arg
105 110 115
ttc acc atg gct gac gtg ctg tcc ttc cga ctg cgt cag aaa cca gtc 499
Phe Thr Met Ala Asp Val Leu Ser Phe Arg Leu Arg Gln Lys Pro Val
120 125 130
cgc gtc gct gcg gcc tgc ggt acc ctc gcg gtt acc ctc ttt tac ttg 547
Arg Val Ala Ala Ala Cys Gly Thr Leu Ala Val Thr Leu Phe Tyr Leu
135 140 145
atc gct cag atg gct ggt gca ggt tcg ctt gtg tcc gtt ctg ctg gac 595
Ile Ala Gln Met Ala Gly Ala Gly Ser Leu Val Ser Val Leu Leu Asp
150 155 160 165
atc cac gag ttc aag tgg cag gca gtt gtt gtc ggt atc gtt ggc att 643
Ile His Glu Phe Lys Trp Gln Ala Val Val Val Gly Ile Val Gly Ile
170 175 180
gtc atg atc gcc tac gtt ctt ctt ggc ggt atg aag ggc acc aca tac 691
Val Met Ile Ala Tyr Val Leu Leu Gly Gly Met Lys Gly Thr Thr Tyr
185 190 195
gtt cag atg att aag gca gtt ctg ctg gtc ggt ggc gtt gcc att atg 739
Val Gln Met Ile Lys Ala Val Leu Leu Val Gly Gly Val Ala Ile Met
200 205 210
acc gtt ctg acc ttc gtc aag gtg tct ggt ggc ctg acc acc ctt tta 787
Thr Val Leu Thr Phe Val Lys Val Ser Gly Gly Leu Thr Thr Leu Leu
215 220 225
aat gac gct gtt gag aag cac gcc gct tca gat tac gct gcc acc aag 835
Asn Asp Ala Val Glu Lys His Ala Ala Ser Asp Tyr Ala Ala Thr Lys
230 235 240 245
ggg tac gat cca acc cag atc ctg gag cct ggt ctg cag tac ggt gca 883
Gly Tyr Asp Pro Thr Gln Ile Leu Glu Pro Gly Leu Gln Tyr Gly Ala
250 255 260
act ctg acc act cag ctg gac ttc att tcc ttg gct ctc gct ctg tgt 931
Thr Leu Thr Thr Gln Leu Asp Phe Ile Ser Leu Ala Leu Ala Leu Cys
265 270 275
ctt gga acc gct ggt ctg cca cac gtt ctg atg cgc ttc tac acc gtt 979
Leu Gly Thr Ala Gly Leu Pro His Val Leu Met Arg Phe Tyr Thr Val
280 285 290
cct acc gcc aag gaa gca cgt aag tct gtg acc tgg gct atc gtc ctc 1027
Pro Thr Ala Lys Glu Ala Arg Lys Ser Val Thr Trp Ala Ile Val Leu
295 300 305
att ggt gcg ttc tac ctg atg acc ctg gtc ctt ggt tac ggc gct gcg 1075
Ile Gly Ala Phe Tyr Leu Met Thr Leu Val Leu Gly Tyr Gly Ala Ala
310 315 320 325
gca ctg gtc ggt cca gac cgc gtc att gcc gca cca ggt gct gct aat 1123
Ala Leu Val Gly Pro Asp Arg Val Ile Ala Ala Pro Gly Ala Ala Asn
330 335 340
gct gct gct cct ctg ctg gcc ttc gag ctt ggt ggt tcc atc ttc atg 1171
Ala Ala Ala Pro Leu Leu Ala Phe Glu Leu Gly Gly Ser Ile Phe Met
345 350 355
gcg ctg att tcc gca gtt gcg ttc gct acc gtt ctc gcc gtg gtc gca 1219
Ala Leu Ile Ser Ala Val Ala Phe Ala Thr Val Leu Ala Val Val Ala
360 365 370
ggt ctt gca att acc gca tcc gct gct gtt ggt cac gac atc tac aac 1267
Gly Leu Ala Ile Thr Ala Ser Ala Ala Val Gly His Asp Ile Tyr Asn
375 380 385
gct gtt atc cgc aac ggt cag tcc acc gaa gcg gag cag gtc cga gta 1315
Ala Val Ile Arg Asn Gly Gln Ser Thr Glu Ala Glu Gln Val Arg Val
390 395 400 405
tcc cgc atc acc gtt gtc gtc att ggc ctg att tcc att gtc ctg gga 1363
Ser Arg Ile Thr Val Val Val Ile Gly Leu Ile Ser Ile Val Leu Gly
410 415 420
att ctt gca atg acc cag aac gtt gcg ttc ctc gtg gcc ctg gcc ttc 1411
Ile Leu Ala Met Thr Gln Asn Val Ala Phe Leu Val Ala Leu Ala Phe
425 430 435
gca gtt gca gca tcc gct aac ctg cca acc atc ctg tac tcc ctg tac 1459
Ala Val Ala Ala Ser Ala Asn Leu Pro Thr Ile Leu Tyr Ser Leu Tyr
440 445 450
tgg aag aag ttc aac acc acc ggc gct gtg gcc gct atc tac acc ggt 1507
Trp Lys Lys Phe Asn Thr Thr Gly Ala Val Ala Ala Ile Tyr Thr Gly
455 460 465
ctc atc tcc gcg ctg ctg ctg atc ttc ctg tcc cca gca gtc tcc ggt 1555
Leu Ile Ser Ala Leu Leu Leu Ile Phe Leu Ser Pro Ala Val Ser Gly
470 475 480 485
aat gac agc gca atg gtt cca ggt gca gac tgg gca atc ttc cca ctg 1603
Asn Asp Ser Ala Met Val Pro Gly Ala Asp Trp Ala Ile Phe Pro Leu
490 495 500
aag aac cca ggc ctc gtc tcc atc cca ctg gca ttc atc gct ggt tgg 1651
Lys Asn Pro Gly Leu Val Ser Ile Pro Leu Ala Phe Ile Ala Gly Trp
505 510 515
atc ggc act ttg gtt ggc aag cca gac aac atg gat gat ctt gct gcc 1699
Ile Gly Thr Leu Val Gly Lys Pro Asp Asn Met Asp Asp Leu Ala Ala
520 525 530
gaa atg gaa gtt cgt tcc ctc acc ggt gtc ggt gtt gaa aag gct gtt 1747
Glu Met Glu Val Arg Ser Leu Thr Gly Val Gly Val Glu Lys Ala Val
535 540 545
gat cac taaatctagt ttctgaagtt att 1776
Asp His
550
<210> 510
<211> 551
<212> PRT
<213> Corynebacterium glutamicum
<400> 510
Met Asn Ser Thr Ile Leu Leu Ala Gln Asp Ala Val Ser Glu Gly Val
1 5 10 15
Gly Asn Pro Ile Leu Asn Ile Ser Val Phe Val Val Phe Ile Ile Val
20 25 30
Thr Met Thr Val Val Leu Arg Val Gly Lys Ser Thr Ser Glu Ser Thr
35 40 45
Asp Phe Tyr Thr Gly Gly Ala Ser Phe Ser Gly Thr Gln Asn Gly Leu
50 55 60
Ala Ile Ala Gly Asp Tyr Leu Ser Ala Ala Ser Phe Leu Gly Ile Val
65 70 75 80
Gly Ala Ile Ser Leu Asn Gly Tyr Asp Gly Phe Leu Tyr Ser Ile Gly
85 90 95
Phe Phe Val Ala Trp Leu Val Ala Leu Leu Leu Val Ala Glu Pro Leu
100 105 110
Arg Asn Val Gly Arg Phe Thr Met Ala Asp Val Leu Ser Phe Arg Leu
115 120 125
Arg Gln Lys Pro Val Arg Val Ala Ala Ala Cys Gly Thr Leu Ala Val
130 135 140
Thr Leu Phe Tyr Leu Ile Ala Gln Met Ala Gly Ala Gly Ser Leu Val
145 150 155 160
Ser Val Leu Leu Asp Ile His Glu Phe Lys Trp Gln Ala Val Val Val
165 170 175
Gly Ile Val Gly Ile Val Met Ile Ala Tyr Val Leu Leu Gly Gly Met
180 185 190
Lys Gly Thr Thr Tyr Val Gln Met Ile Lys Ala Val Leu Leu Val Gly
195 200 205
Gly Val Ala Ile Met Thr Val Leu Thr Phe Val Lys Val Ser Gly Gly
210 215 220
Leu Thr Thr Leu Leu Asn Asp Ala Val Glu Lys His Ala Ala Ser Asp
225 230 235 240
Tyr Ala Ala Thr Lys Gly Tyr Asp Pro Thr Gln Ile Leu Glu Pro Gly
245 250 255
Leu Gln Tyr Gly Ala Thr Leu Thr Thr Gln Leu Asp Phe Ile Ser Leu
260 265 270
Ala Leu Ala Leu Cys Leu Gly Thr Ala Gly Leu Pro His Val Leu Met
275 280 285
Arg Phe Tyr Thr Val Pro Thr Ala Lys Glu Ala Arg Lys Ser Val Thr
290 295 300
Trp Ala Ile Val Leu Ile Gly Ala Phe Tyr Leu Met Thr Leu Val Leu
305 310 315 320
Gly Tyr Gly Ala Ala Ala Leu Val Gly Pro Asp Arg Val Ile Ala Ala
325 330 335
Pro Gly Ala Ala Asn Ala Ala Ala Pro Leu Leu Ala Phe Glu Leu Gly
340 345 350
Gly Ser Ile Phe Met Ala Leu Ile Ser Ala Val Ala Phe Ala Thr Val
355 360 365
Leu Ala Val Val Ala Gly Leu Ala Ile Thr Ala Ser Ala Ala Val Gly
370 375 380
His Asp Ile Tyr Asn Ala Val Ile Arg Asn Gly Gln Ser Thr Glu Ala
385 390 395 400
Glu Gln Val Arg Val Ser Arg Ile Thr Val Val Val Ile Gly Leu Ile
405 410 415
Ser Ile Val Leu Gly Ile Leu Ala Met Thr Gln Asn Val Ala Phe Leu
420 425 430
Val Ala Leu Ala Phe Ala Val Ala Ala Ser Ala Asn Leu Pro Thr Ile
435 440 445
Leu Tyr Ser Leu Tyr Trp Lys Lys Phe Asn Thr Thr Gly Ala Val Ala
450 455 460
Ala Ile Tyr Thr Gly Leu Ile Ser Ala Leu Leu Leu Ile Phe Leu Ser
465 470 475 480
Pro Ala Val Ser Gly Asn Asp Ser Ala Met Val Pro Gly Ala Asp Trp
485 490 495
Ala Ile Phe Pro Leu Lys Asn Pro Gly Leu Val Ser Ile Pro Leu Ala
500 505 510
Phe Ile Ala Gly Trp Ile Gly Thr Leu Val Gly Lys Pro Asp Asn Met
515 520 525
Asp Asp Leu Ala Ala Glu Met Glu Val Arg Ser Leu Thr Gly Val Gly
530 535 540
Val Glu Lys Ala Val Asp His
545 550
<210> 511
<211> 1333
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1333)
<223> RXA00902
<400> 511
ttgttattgg tttgttcact cccatgcaat gtacgatcgg ttctaacgtc tacggcaatt 60
gacacgtcaa tttaattcag gaaaggggtg gggagaattt atg tct agt ggt ttt 115
Met Ser Ser Gly Phe
1 5
gaa tat gtt caa cat cct cga cga gcc ctc cct ccg cct ata cct gaa 163
Glu Tyr Val Gln His Pro Arg Arg Ala Leu Pro Pro Pro Ile Pro Glu
10 15 20
cgg aaa ggt cct gcc gca gca ttc ctg ccg gga act ttc cat ccc att 211
Arg Lys Gly Pro Ala Ala Ala Phe Leu Pro Gly Thr Phe His Pro Ile
25 30 35
aat cca aag aat att gca gcg agc cac gat cag gtg ctt cta tct ggt 259
Asn Pro Lys Asn Ile Ala Ala Ser His Asp Gln Val Leu Leu Ser Gly
40 45 50
tgg ggc aaa ttt gtg cgt tgg ctc ttg gta ttg ttg tcc att ttg gtc 307
Trp Gly Lys Phe Val Arg Trp Leu Leu Val Leu Leu Ser Ile Leu Val
55 60 65
atc atc att ggc atc aac ctc atc ttg gac ggt gtc tac gga ttt ggt 355
Ile Ile Ile Gly Ile Asn Leu Ile Leu Asp Gly Val Tyr Gly Phe Gly
70 75 80 85
act ttt tca acc acc cag atg tac caa gtt gcg aaa gat cca ctc att 403
Thr Phe Ser Thr Thr Gln Met Tyr Gln Val Ala Lys Asp Pro Leu Ile
90 95 100
ggt gtg ctg atc ggt atc ttg gct acg gcc ttg gtg caa tca tca acc 451
Gly Val Leu Ile Gly Ile Leu Ala Thr Ala Leu Val Gln Ser Ser Thr
105 110 115
acc acc aca acg ttg acg gtg act gca gtt ggt acg ggc att gtg tcg 499
Thr Thr Thr Thr Leu Thr Val Thr Ala Val Gly Thr Gly Ile Val Ser
120 125 130
gtg cct gtg gcg att ccg atc att ctt ggc gca aat atc ggt acg acg 547
Val Pro Val Ala Ile Pro Ile Ile Leu Gly Ala Asn Ile Gly Thr Thr
135 140 145
atc acc gcg atg ctc gtt gcg ttt tct tat gtg ggt gaa cgc agg gag 595
Ile Thr Ala Met Leu Val Ala Phe Ser Tyr Val Gly Glu Arg Arg Glu
150 155 160 165
ttt aag cga gct ttt acg gtt gcc gcc atg cat gtg tgg ttt aac gtg 643
Phe Lys Arg Ala Phe Thr Val Ala Ala Met His Val Trp Phe Asn Val
170 175 180
ctc gtc att ctt gtt cta ttt gtt gtg gaa ttg ctc ttt cat cca ttc 691
Leu Val Ile Leu Val Leu Phe Val Val Glu Leu Leu Phe His Pro Phe
185 190 195
cgc aca att agt ggt gcg atc gca acg gag atc aca ctg aca act ggt 739
Arg Thr Ile Ser Gly Ala Ile Ala Thr Glu Ile Thr Leu Thr Thr Gly
200 205 210
ggc tct ttg cct acc agt ggt gtg atg acc aag att ttt gat ccc cca 787
Gly Ser Leu Pro Thr Ser Gly Val Met Thr Lys Ile Phe Asp Pro Pro
215 220 225
acc caa ctt ctg ggt atg aat ggt ctt atc ggt tcg atc ggc aat cct 835
Thr Gln Leu Leu Gly Met Asn Gly Leu Ile Gly Ser Ile Gly Asn Pro
230 235 240 245
agt att tcg gcg att gta tgt ctt gtg gtg ggc acc att ctt att ctg 883
Ser Ile Ser Ala Ile Val Cys Leu Val Val Gly Thr Ile Leu Ile Leu
250 255 260
att tcg gtg cgt gcc atg agt tct cag atc cga acc att acg gca gcg 931
Ile Ser Val Arg Ala Met Ser Ser Gln Ile Arg Thr Ile Thr Ala Ala
265 270 275
acc gta acc tca att atg gac aag gtg atc aat cca gag aac agc ccc 979
Thr Val Thr Ser Ile Met Asp Lys Val Ile Asn Pro Glu Asn Ser Pro
280 285 290
aag gcg acg att ctt tcc aat ttc tgg agc ttc att ctt gga gtt ttg 1027
Lys Ala Thr Ile Leu Ser Asn Phe Trp Ser Phe Ile Leu Gly Val Leu
295 300 305
ttc acg ctc atg gtc act gcc tcg tca gtg acc gtg gct tcc atg cag 1075
Phe Thr Leu Met Val Thr Ala Ser Ser Val Thr Val Ala Ser Met Gln
310 315 320 325
cca gtg gct gcc tct ggt gtc gtt aag caa aag cca ttg ctg ggc gtc 1123
Pro Val Ala Ala Ser Gly Val Val Lys Gln Lys Pro Leu Leu Gly Val
330 335 340
att ttg ggt gcc aac gtg ggc acc acg gtg acc gca atg ttt gct act 1171
Ile Leu Gly Ala Asn Val Gly Thr Thr Val Thr Ala Met Phe Ala Thr
345 350 355
ttc gcg att gtc agc gat cag ggt gag ttc gct att cag gct gcg ttg 1219
Phe Ala Ile Val Ser Asp Gln Gly Glu Phe Ala Ile Gln Ala Ala Leu
360 365 370
atc cac ctc att gtg aac ttc acc ggc gca tta cta gtg ctg tgt att 1267
Ile His Leu Ile Val Asn Phe Thr Gly Ala Leu Leu Val Leu Cys Ile
375 380 385
ccg cag ctt gcc aat gtg att att cac ttg gcc gag aaa act gcg aac 1315
Pro Gln Leu Ala Asn Val Ile Ile His Leu Ala Glu Lys Thr Ala Asn
390 395 400 405
ctc act gcc cgc agt tac 1333
Leu Thr Ala Arg Ser Tyr
410
<210> 512
<211> 411
<212> PRT
<213> Corynebacterium glutamicum
<400> 512
Met Ser Ser Gly Phe Glu Tyr Val Gln His Pro Arg Arg Ala Leu Pro
1 5 10 15
Pro Pro Ile Pro Glu Arg Lys Gly Pro Ala Ala Ala Phe Leu Pro Gly
20 25 30
Thr Phe His Pro Ile Asn Pro Lys Asn Ile Ala Ala Ser His Asp Gln
35 40 45
Val Leu Leu Ser Gly Trp Gly Lys Phe Val Arg Trp Leu Leu Val Leu
50 55 60
Leu Ser Ile Leu Val Ile Ile Ile Gly Ile Asn Leu Ile Leu Asp Gly
65 70 75 80
Val Tyr Gly Phe Gly Thr Phe Ser Thr Thr Gln Met Tyr Gln Val Ala
85 90 95
Lys Asp Pro Leu Ile Gly Val Leu Ile Gly Ile Leu Ala Thr Ala Leu
100 105 110
Val Gln Ser Ser Thr Thr Thr Thr Thr Leu Thr Val Thr Ala Val Gly
115 120 125
Thr Gly Ile Val Ser Val Pro Val Ala Ile Pro Ile Ile Leu Gly Ala
130 135 140
Asn Ile Gly Thr Thr Ile Thr Ala Met Leu Val Ala Phe Ser Tyr Val
145 150 155 160
Gly Glu Arg Arg Glu Phe Lys Arg Ala Phe Thr Val Ala Ala Met His
165 170 175
Val Trp Phe Asn Val Leu Val Ile Leu Val Leu Phe Val Val Glu Leu
180 185 190
Leu Phe His Pro Phe Arg Thr Ile Ser Gly Ala Ile Ala Thr Glu Ile
195 200 205
Thr Leu Thr Thr Gly Gly Ser Leu Pro Thr Ser Gly Val Met Thr Lys
210 215 220
Ile Phe Asp Pro Pro Thr Gln Leu Leu Gly Met Asn Gly Leu Ile Gly
225 230 235 240
Ser Ile Gly Asn Pro Ser Ile Ser Ala Ile Val Cys Leu Val Val Gly
245 250 255
Thr Ile Leu Ile Leu Ile Ser Val Arg Ala Met Ser Ser Gln Ile Arg
260 265 270
Thr Ile Thr Ala Ala Thr Val Thr Ser Ile Met Asp Lys Val Ile Asn
275 280 285
Pro Glu Asn Ser Pro Lys Ala Thr Ile Leu Ser Asn Phe Trp Ser Phe
290 295 300
Ile Leu Gly Val Leu Phe Thr Leu Met Val Thr Ala Ser Ser Val Thr
305 310 315 320
Val Ala Ser Met Gln Pro Val Ala Ala Ser Gly Val Val Lys Gln Lys
325 330 335
Pro Leu Leu Gly Val Ile Leu Gly Ala Asn Val Gly Thr Thr Val Thr
340 345 350
Ala Met Phe Ala Thr Phe Ala Ile Val Ser Asp Gln Gly Glu Phe Ala
355 360 365
Ile Gln Ala Ala Leu Ile His Leu Ile Val Asn Phe Thr Gly Ala Leu
370 375 380
Leu Val Leu Cys Ile Pro Gln Leu Ala Asn Val Ile Ile His Leu Ala
385 390 395 400
Glu Lys Thr Ala Asn Leu Thr Ala Arg Ser Tyr
405 410
<210> 513
<211> 1440
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1417)
<223> RXA00941
<400> 513
agccggggtg gccgtttgcg tgtacgggtt ttgcttatcg acgcccactt ctgattttaa 60
aggcaaatat tttgtgtcac agcgagtaat cttttcgggc atg aac cta acc cgg 115
Met Asn Leu Thr Arg
1 5
aat gac agg ctc gat cga ctg ccc gta act tcc aaa cat aaa aag att 163
Asn Asp Arg Leu Asp Arg Leu Pro Val Thr Ser Lys His Lys Lys Ile
10 15 20
ctt ggc ggc tca ggt atc ggc tgg gca ttg gat gcc atg gat gtc gga 211
Leu Gly Gly Ser Gly Ile Gly Trp Ala Leu Asp Ala Met Asp Val Gly
25 30 35
ctg atc tct ttc gtc atg gct gcg ttg gcc act cat tgg ggc cta tcc 259
Leu Ile Ser Phe Val Met Ala Ala Leu Ala Thr His Trp Gly Leu Ser
40 45 50
cct act gaa act tcc ctg ctc gga tcc atc ggt ttc gtt ggc atg gcc 307
Pro Thr Glu Thr Ser Leu Leu Gly Ser Ile Gly Phe Val Gly Met Ala
55 60 65
atc ggc gct tcg ctg ggc ggt ttg ctg gcg gac aag ttg ggg cgt cga 355
Ile Gly Ala Ser Leu Gly Gly Leu Leu Ala Asp Lys Leu Gly Arg Arg
70 75 80 85
caa gtt ttt gcg ttg tct ttg cta gtt tat ggc gtt gcc act ggc gcg 403
Gln Val Phe Ala Leu Ser Leu Leu Val Tyr Gly Val Ala Thr Gly Ala
90 95 100
tcg gcg ctt tca gtg tcg ctg gca atg ttg atg gcg ctg cgc ttc gtc 451
Ser Ala Leu Ser Val Ser Leu Ala Met Leu Met Ala Leu Arg Phe Val
105 110 115
gtt gga ctt ggc ctg ggc gct gaa ctc ccc gtt gca tcc act ctg att 499
Val Gly Leu Gly Leu Gly Ala Glu Leu Pro Val Ala Ser Thr Leu Ile
120 125 130
tcc gag ttt tct cca cga aaa gtt cgt ggc cgc atg gtc gtt atc ctg 547
Ser Glu Phe Ser Pro Arg Lys Val Arg Gly Arg Met Val Val Ile Leu
135 140 145
gag gcg ttt tgg gcg ctg ggc tgg atc atg gct gca atc gtc gga acc 595
Glu Ala Phe Trp Ala Leu Gly Trp Ile Met Ala Ala Ile Val Gly Thr
150 155 160 165
ttt gtc gtg gca gga tcc gat aat ggt tgg cgt tgg gcg tta gct ctt 643
Phe Val Val Ala Gly Ser Asp Asn Gly Trp Arg Trp Ala Leu Ala Leu
170 175 180
ggc tgt gtc cct gca att tac gcg gtg tat gtc cgt ctc gga ctt cca 691
Gly Cys Val Pro Ala Ile Tyr Ala Val Tyr Val Arg Leu Gly Leu Pro
185 190 195
gaa tca gta cgt ttc ctg gag aag aaa ggc cgg cac gac gaa gca gaa 739
Glu Ser Val Arg Phe Leu Glu Lys Lys Gly Arg His Asp Glu Ala Glu
200 205 210
gcc atc gtt gtt tcc ttc gaa gaa gct gcc gct gcc gaa ggt aaa gct 787
Ala Ile Val Val Ser Phe Glu Glu Ala Ala Ala Ala Glu Gly Lys Ala
215 220 225
gcc gat gcc acc acc gct gtg gtt cat gac aac gct gcc gag ggt tcc 835
Ala Asp Ala Thr Thr Ala Val Val His Asp Asn Ala Ala Glu Gly Ser
230 235 240 245
gta tcc atc tgg tca gct gct ttg cgc aag cgc acc gtc gcg ctg tgg 883
Val Ser Ile Trp Ser Ala Ala Leu Arg Lys Arg Thr Val Ala Leu Trp
250 255 260
atc gtg tgg ttc tgc atc aac ttg tcc tac tac gga gcc ttc att tgg 931
Ile Val Trp Phe Cys Ile Asn Leu Ser Tyr Tyr Gly Ala Phe Ile Trp
265 270 275
att cca tcg ctg ctg gtt gcc gac ggt ttc acc ctc gtg aag tct ttc 979
Ile Pro Ser Leu Leu Val Ala Asp Gly Phe Thr Leu Val Lys Ser Phe
280 285 290
caa ttc act ctg atc atc acc ttg gct cag ctt cca ggc tat gcg gtt 1027
Gln Phe Thr Leu Ile Ile Thr Leu Ala Gln Leu Pro Gly Tyr Ala Val
295 300 305
gca gcg tgg ttg att gaa aag tgg ggc cgt cgc agc aca ttg gcc acg 1075
Ala Ala Trp Leu Ile Glu Lys Trp Gly Arg Arg Ser Thr Leu Ala Thr
310 315 320 325
ttc ctg gtt ggt tct gct atc tct gca gcg ctc tac ggc ttg gca aat 1123
Phe Leu Val Gly Ser Ala Ile Ser Ala Ala Leu Tyr Gly Leu Ala Asn
330 335 340
gtg gag tgg cag atc ctg gtc gca ggt tgt tta cta tcc ttc ttc aac 1171
Val Glu Trp Gln Ile Leu Val Ala Gly Cys Leu Leu Ser Phe Phe Asn
345 350 355
ctg ggc gca tgg ggc gca ctg tat gcc att ggg ccg gag ctt tat ccc 1219
Leu Gly Ala Trp Gly Ala Leu Tyr Ala Ile Gly Pro Glu Leu Tyr Pro
360 365 370
act aat gtc cgt gga act gga acg ggt gct gcc gcg gga ttc ggg cgc 1267
Thr Asn Val Arg Gly Thr Gly Thr Gly Ala Ala Ala Gly Phe Gly Arg
375 380 385
att gct tcc atc atc gct ccg ctc att gtt ccg cca gtg att gct ttt 1315
Ile Ala Ser Ile Ile Ala Pro Leu Ile Val Pro Pro Val Ile Ala Phe
390 395 400 405
ggt gga cca att gct ttg ttc gct ctc ttt gcc acc gcg ttt gcg atc 1363
Gly Gly Pro Ile Ala Leu Phe Ala Leu Phe Ala Thr Ala Phe Ala Ile
410 415 420
gca gcg att gcg gcg ttt acg ctg cct gag cag aag ggt aag tct ctc 1411
Ala Ala Ile Ala Ala Phe Thr Leu Pro Glu Gln Lys Gly Lys Ser Leu
425 430 435
gct gat tagtgagatc cttccaccag ttt 1440
Ala Asp
<210> 514
<211> 439
<212> PRT
<213> Corynebacterium glutamicum
<400> 514
Met Asn Leu Thr Arg Asn Asp Arg Leu Asp Arg Leu Pro Val Thr Ser
1 5 10 15
Lys His Lys Lys Ile Leu Gly Gly Ser Gly Ile Gly Trp Ala Leu Asp
20 25 30
Ala Met Asp Val Gly Leu Ile Ser Phe Val Met Ala Ala Leu Ala Thr
35 40 45
His Trp Gly Leu Ser Pro Thr Glu Thr Ser Leu Leu Gly Ser Ile Gly
50 55 60
Phe Val Gly Met Ala Ile Gly Ala Ser Leu Gly Gly Leu Leu Ala Asp
65 70 75 80
Lys Leu Gly Arg Arg Gln Val Phe Ala Leu Ser Leu Leu Val Tyr Gly
85 90 95
Val Ala Thr Gly Ala Ser Ala Leu Ser Val Ser Leu Ala Met Leu Met
100 105 110
Ala Leu Arg Phe Val Val Gly Leu Gly Leu Gly Ala Glu Leu Pro Val
115 120 125
Ala Ser Thr Leu Ile Ser Glu Phe Ser Pro Arg Lys Val Arg Gly Arg
130 135 140
Met Val Val Ile Leu Glu Ala Phe Trp Ala Leu Gly Trp Ile Met Ala
145 150 155 160
Ala Ile Val Gly Thr Phe Val Val Ala Gly Ser Asp Asn Gly Trp Arg
165 170 175
Trp Ala Leu Ala Leu Gly Cys Val Pro Ala Ile Tyr Ala Val Tyr Val
180 185 190
Arg Leu Gly Leu Pro Glu Ser Val Arg Phe Leu Glu Lys Lys Gly Arg
195 200 205
His Asp Glu Ala Glu Ala Ile Val Val Ser Phe Glu Glu Ala Ala Ala
210 215 220
Ala Glu Gly Lys Ala Ala Asp Ala Thr Thr Ala Val Val His Asp Asn
225 230 235 240
Ala Ala Glu Gly Ser Val Ser Ile Trp Ser Ala Ala Leu Arg Lys Arg
245 250 255
Thr Val Ala Leu Trp Ile Val Trp Phe Cys Ile Asn Leu Ser Tyr Tyr
260 265 270
Gly Ala Phe Ile Trp Ile Pro Ser Leu Leu Val Ala Asp Gly Phe Thr
275 280 285
Leu Val Lys Ser Phe Gln Phe Thr Leu Ile Ile Thr Leu Ala Gln Leu
290 295 300
Pro Gly Tyr Ala Val Ala Ala Trp Leu Ile Glu Lys Trp Gly Arg Arg
305 310 315 320
Ser Thr Leu Ala Thr Phe Leu Val Gly Ser Ala Ile Ser Ala Ala Leu
325 330 335
Tyr Gly Leu Ala Asn Val Glu Trp Gln Ile Leu Val Ala Gly Cys Leu
340 345 350
Leu Ser Phe Phe Asn Leu Gly Ala Trp Gly Ala Leu Tyr Ala Ile Gly
355 360 365
Pro Glu Leu Tyr Pro Thr Asn Val Arg Gly Thr Gly Thr Gly Ala Ala
370 375 380
Ala Gly Phe Gly Arg Ile Ala Ser Ile Ile Ala Pro Leu Ile Val Pro
385 390 395 400
Pro Val Ile Ala Phe Gly Gly Pro Ile Ala Leu Phe Ala Leu Phe Ala
405 410 415
Thr Ala Phe Ala Ile Ala Ala Ile Ala Ala Phe Thr Leu Pro Glu Gln
420 425 430
Lys Gly Lys Ser Leu Ala Asp
435
<210> 515
<211> 1704
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1681)
<223> RXN00449
<400> 515
tcgttggctt acatggtcat tgatgaccgg gctgaatatg tgagaaaatc catcccttct 60
ttaagcaagg gagtgaatta cagaaaagga ttgttcagca atg agc aca cct gac 115
Met Ser Thr Pro Asp
1 5
att aaa gaa ggc tcg gca gaa tca ccg ggc gaa gta atg gtc gtt gga 163
Ile Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu Val Met Val Val Gly
10 15 20
gac agg cga gag tgg cgt cga caa gca acc ggc atc att gcc ggc ctc 211
Asp Arg Arg Glu Trp Arg Arg Gln Ala Thr Gly Ile Ile Ala Gly Leu
25 30 35
gtc tta gcc gcc ctg gtc tat ctt ctc ttc ccc tcg aac tcc gtg gaa 259
Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro Ser Asn Ser Val Glu
40 45 50
acc gtc atg caa tcc agt ggc gtc gat cca gaa act gaa tac acc aac 307
Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu Thr Glu Tyr Thr Asn
55 60 65
aac gcg atg cgt ctt act gct gca gtc aca atc ttg atg gca gtg tgg 355
Asn Ala Met Arg Leu Thr Ala Ala Val Thr Ile Leu Met Ala Val Trp
70 75 80 85
tgg atg aca gaa gca atc cca cta gca gca acc gca ctt atc ccg ttg 403
Trp Met Thr Glu Ala Ile Pro Leu Ala Ala Thr Ala Leu Ile Pro Leu
90 95 100
gtt gca ttc cct gct ttc cag gtt gtg gac ttt ggg aag gca aca gct 451
Val Ala Phe Pro Ala Phe Gln Val Val Asp Phe Gly Lys Ala Thr Ala
105 110 115
ccg tat gcc aac cct acg agc ttc ctc ttc ttg ggc ggc ttt ctt atg 499
Pro Tyr Ala Asn Pro Thr Ser Phe Leu Phe Leu Gly Gly Phe Leu Met
120 125 130
gca ctt ggc ctg cag aaa tgg aac cta cac cga cgt atg gct cta gcg 547
Ala Leu Gly Leu Gln Lys Trp Asn Leu His Arg Arg Met Ala Leu Ala
135 140 145
gtc gtg cta gct gtt ggt act aag cca aag caa ttg gtc ttg ggt ttt 595
Val Val Leu Ala Val Gly Thr Lys Pro Lys Gln Leu Val Leu Gly Phe
150 155 160 165
atg gtg gca act gga ttt ttg tcc atg tgg gtg tct aac act gca acg 643
Met Val Ala Thr Gly Phe Leu Ser Met Trp Val Ser Asn Thr Ala Thr
170 175 180
gcc gtg gtt atg tta ccg atc ggt atg tcg gta ctg gca ctg acc gct 691
Ala Val Val Met Leu Pro Ile Gly Met Ser Val Leu Ala Leu Thr Ala
185 190 195
gag act gtg ggc gga atg aaa aac caa aag aaa ttc gcc act gga ctc 739
Glu Thr Val Gly Gly Met Lys Asn Gln Lys Lys Phe Ala Thr Gly Leu
200 205 210
atg ctg tcc att gct tat tct gct tcc atc ggt tca ctc ggc acc tta 787
Met Leu Ser Ile Ala Tyr Ser Ala Ser Ile Gly Ser Leu Gly Thr Leu
215 220 225
att ggc acg cca ccc aat gcc ttg ctt gct gcg tat atg tct gaa tcg 835
Ile Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala Tyr Met Ser Glu Ser
230 235 240 245
cat gat atc cac atc gga ttt ggt cag tgg atg att ctt ggt gta cca 883
His Asp Ile His Ile Gly Phe Gly Gln Trp Met Ile Leu Gly Val Pro
250 255 260
att gct gtc gtc ttc acc atc atc gcg tgg ctt gtg ttg acc acc gtg 931
Ile Ala Val Val Phe Thr Ile Ile Ala Trp Leu Val Leu Thr Thr Val
265 270 275
ttc aag cca gaa atg aaa gaa atc cct ggc gga cgt gaa ctg atc aaa 979
Phe Lys Pro Glu Met Lys Glu Ile Pro Gly Gly Arg Glu Leu Ile Lys
280 285 290
cgt gaa atc gct gaa atg ggg ccg tgg act gca cct cag gtc aca gtg 1027
Arg Glu Ile Ala Glu Met Gly Pro Trp Thr Ala Pro Gln Val Thr Val
295 300 305
ggt gtt att ttt gcg gca gct gca ctg gct tgg gtc ttc att cca tta 1075
Gly Val Ile Phe Ala Ala Ala Ala Leu Ala Trp Val Phe Ile Pro Leu
310 315 320 325
act cta gat tgg acc ggt tcc cag ctc tct atc aat gac tcc ctc att 1123
Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser Ile Asn Asp Ser Leu Ile
330 335 340
ggc atc gct gcc ggc ctg ctg atg ttt atc gtt ccc gct aac ttt aaa 1171
Gly Ile Ala Ala Gly Leu Leu Met Phe Ile Val Pro Ala Asn Phe Lys
345 350 355
acc ggc gaa cgc att ctt gat tgg cgt act gca ggc gaa ctt cca tgg 1219
Thr Gly Glu Arg Ile Leu Asp Trp Arg Thr Ala Gly Glu Leu Pro Trp
360 365 370
gat gtt ctc ttg ctt ttt ggt ggc ggg ctt tca ctt tct gcg atg ttt 1267
Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ser Leu Ser Ala Met Phe
375 380 385
acc agc acg gga ctt tcc cta tgg atc ggt gaa cta gct aag gga ctt 1315
Thr Ser Thr Gly Leu Ser Leu Trp Ile Gly Glu Leu Ala Lys Gly Leu
390 395 400 405
gat gcc ctt cca atc ttc att ctc atc ttc gcc att gct gtc ctg gtg 1363
Asp Ala Leu Pro Ile Phe Ile Leu Ile Phe Ala Ile Ala Val Leu Val
410 415 420
ttg ttc ctg acc gag ttc acc tcc aac acc gca aca gcg gca acc ttc 1411
Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Ala Thr Ala Ala Thr Phe
425 430 435
ctg cca atc atg ggt ggc gtc gcc gta ggt atc gga ctg acc gca ggt 1459
Leu Pro Ile Met Gly Gly Val Ala Val Gly Ile Gly Leu Thr Ala Gly
440 445 450
ggc gag cag aat gtt ctg ctg ctg acc atc cca gtc gca ctg tcc gca 1507
Gly Glu Gln Asn Val Leu Leu Leu Thr Ile Pro Val Ala Leu Ser Ala
455 460 465
acc tgt gcg ttc atg ctt cca gtg gca acg cct cca aac gcg att gca 1555
Thr Cys Ala Phe Met Leu Pro Val Ala Thr Pro Pro Asn Ala Ile Ala
470 475 480 485
ttc ggc tcc ggc tac att aag atc ggc gaa atg gtc aag ggt ggt ctg 1603
Phe Gly Ser Gly Tyr Ile Lys Ile Gly Glu Met Val Lys Gly Gly Leu
490 495 500
tgg ctg aac atc atc gca gtc atc ctc att acg att ttc acc tac ttc 1651
Trp Leu Asn Ile Ile Ala Val Ile Leu Ile Thr Ile Phe Thr Tyr Phe
505 510 515
gta gcg atc cca ctc ttt ggc atc atg ctt taaaagttaa caggcccgca 1701
Val Ala Ile Pro Leu Phe Gly Ile Met Leu
520 525
gtc 1704
<210> 516
<211> 527
<212> PRT
<213> Corynebacterium glutamicum
<400> 516
Met Ser Thr Pro Asp Ile Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu
1 5 10 15
Val Met Val Val Gly Asp Arg Arg Glu Trp Arg Arg Gln Ala Thr Gly
20 25 30
Ile Ile Ala Gly Leu Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro
35 40 45
Ser Asn Ser Val Glu Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu
50 55 60
Thr Glu Tyr Thr Asn Asn Ala Met Arg Leu Thr Ala Ala Val Thr Ile
65 70 75 80
Leu Met Ala Val Trp Trp Met Thr Glu Ala Ile Pro Leu Ala Ala Thr
85 90 95
Ala Leu Ile Pro Leu Val Ala Phe Pro Ala Phe Gln Val Val Asp Phe
100 105 110
Gly Lys Ala Thr Ala Pro Tyr Ala Asn Pro Thr Ser Phe Leu Phe Leu
115 120 125
Gly Gly Phe Leu Met Ala Leu Gly Leu Gln Lys Trp Asn Leu His Arg
130 135 140
Arg Met Ala Leu Ala Val Val Leu Ala Val Gly Thr Lys Pro Lys Gln
145 150 155 160
Leu Val Leu Gly Phe Met Val Ala Thr Gly Phe Leu Ser Met Trp Val
165 170 175
Ser Asn Thr Ala Thr Ala Val Val Met Leu Pro Ile Gly Met Ser Val
180 185 190
Leu Ala Leu Thr Ala Glu Thr Val Gly Gly Met Lys Asn Gln Lys Lys
195 200 205
Phe Ala Thr Gly Leu Met Leu Ser Ile Ala Tyr Ser Ala Ser Ile Gly
210 215 220
Ser Leu Gly Thr Leu Ile Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala
225 230 235 240
Tyr Met Ser Glu Ser His Asp Ile His Ile Gly Phe Gly Gln Trp Met
245 250 255
Ile Leu Gly Val Pro Ile Ala Val Val Phe Thr Ile Ile Ala Trp Leu
260 265 270
Val Leu Thr Thr Val Phe Lys Pro Glu Met Lys Glu Ile Pro Gly Gly
275 280 285
Arg Glu Leu Ile Lys Arg Glu Ile Ala Glu Met Gly Pro Trp Thr Ala
290 295 300
Pro Gln Val Thr Val Gly Val Ile Phe Ala Ala Ala Ala Leu Ala Trp
305 310 315 320
Val Phe Ile Pro Leu Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser Ile
325 330 335
Asn Asp Ser Leu Ile Gly Ile Ala Ala Gly Leu Leu Met Phe Ile Val
340 345 350
Pro Ala Asn Phe Lys Thr Gly Glu Arg Ile Leu Asp Trp Arg Thr Ala
355 360 365
Gly Glu Leu Pro Trp Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ser
370 375 380
Leu Ser Ala Met Phe Thr Ser Thr Gly Leu Ser Leu Trp Ile Gly Glu
385 390 395 400
Leu Ala Lys Gly Leu Asp Ala Leu Pro Ile Phe Ile Leu Ile Phe Ala
405 410 415
Ile Ala Val Leu Val Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Ala
420 425 430
Thr Ala Ala Thr Phe Leu Pro Ile Met Gly Gly Val Ala Val Gly Ile
435 440 445
Gly Leu Thr Ala Gly Gly Glu Gln Asn Val Leu Leu Leu Thr Ile Pro
450 455 460
Val Ala Leu Ser Ala Thr Cys Ala Phe Met Leu Pro Val Ala Thr Pro
465 470 475 480
Pro Asn Ala Ile Ala Phe Gly Ser Gly Tyr Ile Lys Ile Gly Glu Met
485 490 495
Val Lys Gly Gly Leu Trp Leu Asn Ile Ile Ala Val Ile Leu Ile Thr
500 505 510
Ile Phe Thr Tyr Phe Val Ala Ile Pro Leu Phe Gly Ile Met Leu
515 520 525
<210> 517
<211> 1028
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(1005)
<223> FRXA00449
<400> 517
ctg gca ctg acc gct gag act gtg ggc gga atg aaa aac caa aag aaa 48
Leu Ala Leu Thr Ala Glu Thr Val Gly Gly Met Lys Asn Gln Lys Lys
1 5 10 15
ttc gcc act gga ctc atg ctg tcc att gct tat tct gct tcc atc ggt 96
Phe Ala Thr Gly Leu Met Leu Ser Ile Ala Tyr Ser Ala Ser Ile Gly
20 25 30
tca ctc ggc acc tta att ggc acg cca ccc aat gcc ttg ctt gct gcg 144
Ser Leu Gly Thr Leu Ile Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala
35 40 45
tat atg tct gaa tcg cat gat atc cac atc gga ttt ggt cag tgg atg 192
Tyr Met Ser Glu Ser His Asp Ile His Ile Gly Phe Gly Gln Trp Met
50 55 60
att ctt ggt gta cca att gct gtc gtc ttc acc atc atc gcg tgg ctt 240
Ile Leu Gly Val Pro Ile Ala Val Val Phe Thr Ile Ile Ala Trp Leu
65 70 75 80
gtg ttg acc acc gtg ttc aag cca gaa atg aaa gaa atc cct ggc gga 288
Val Leu Thr Thr Val Phe Lys Pro Glu Met Lys Glu Ile Pro Gly Gly
85 90 95
cgt gaa ctg atc aaa cgt gaa atc gct gaa atg ggg ccg tgg act gca 336
Arg Glu Leu Ile Lys Arg Glu Ile Ala Glu Met Gly Pro Trp Thr Ala
100 105 110
cct cag gtc aca gtg ggt gtt att ttt gcg gca gct gca ctg gct tgg 384
Pro Gln Val Thr Val Gly Val Ile Phe Ala Ala Ala Ala Leu Ala Trp
115 120 125
gtc ttc att cca tta act cta gat tgg acc ggt tcc cag ctc tct atc 432
Val Phe Ile Pro Leu Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser Ile
130 135 140
aat gac tcc ctc att ggc atc gct gcc ggc ctg ctg atg ttt atc gtt 480
Asn Asp Ser Leu Ile Gly Ile Ala Ala Gly Leu Leu Met Phe Ile Val
145 150 155 160
ccc gct aac ttt aaa acc ggc gaa cgc att ctt gat tgg cgt act gca 528
Pro Ala Asn Phe Lys Thr Gly Glu Arg Ile Leu Asp Trp Arg Thr Ala
165 170 175
ggc gaa ctt cca tgg gat gtt ctc ttg ctt ttt ggt ggc ggg ctt tca 576
Gly Glu Leu Pro Trp Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ser
180 185 190
ctt tct gcg atg ttt acc agc acg gga ctt tcc cta tgg atc ggt gaa 624
Leu Ser Ala Met Phe Thr Ser Thr Gly Leu Ser Leu Trp Ile Gly Glu
195 200 205
cta gct aag gga ctt gat gcc ctt cca atc ttc att ctc atc ttc gcc 672
Leu Ala Lys Gly Leu Asp Ala Leu Pro Ile Phe Ile Leu Ile Phe Ala
210 215 220
att gct gtc ctg gtg ttg ttc ctg acc gag ttc acc tcc aac acc gca 720
Ile Ala Val Leu Val Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Ala
225 230 235 240
aca gcg gca acc ttc ctg cca atc atg ggt ggc gtc gcc gta ggt atc 768
Thr Ala Ala Thr Phe Leu Pro Ile Met Gly Gly Val Ala Val Gly Ile
245 250 255
gga ctg acc gca ggt ggc gag cag aat gtt ctg ctg ctg acc atc cca 816
Gly Leu Thr Ala Gly Gly Glu Gln Asn Val Leu Leu Leu Thr Ile Pro
260 265 270
gtc gca ctg tcc gca acc tgt gcg ttc atg ctt cca gtg gca acg cct 864
Val Ala Leu Ser Ala Thr Cys Ala Phe Met Leu Pro Val Ala Thr Pro
275 280 285
cca aac gcg att gca ttc ggc tcc ggc tac att aag atc ggc gaa atg 912
Pro Asn Ala Ile Ala Phe Gly Ser Gly Tyr Ile Lys Ile Gly Glu Met
290 295 300
gtc aag ggt ggt ctg tgg ctg aac atc atc gca gtc atc ctc att acg 960
Val Lys Gly Gly Leu Trp Leu Asn Ile Ile Ala Val Ile Leu Ile Thr
305 310 315 320
att ttc acc tac ttc gta gcg atc cca ctc ttt ggc atc atg ctt 1005
Ile Phe Thr Tyr Phe Val Ala Ile Pro Leu Phe Gly Ile Met Leu
325 330 335
taaaagttaa caggcccgca gtc 1028
<210> 518
<211> 335
<212> PRT
<213> Corynebacterium glutamicum
<400> 518
Leu Ala Leu Thr Ala Glu Thr Val Gly Gly Met Lys Asn Gln Lys Lys
1 5 10 15
Phe Ala Thr Gly Leu Met Leu Ser Ile Ala Tyr Ser Ala Ser Ile Gly
20 25 30
Ser Leu Gly Thr Leu Ile Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala
35 40 45
Tyr Met Ser Glu Ser His Asp Ile His Ile Gly Phe Gly Gln Trp Met
50 55 60
Ile Leu Gly Val Pro Ile Ala Val Val Phe Thr Ile Ile Ala Trp Leu
65 70 75 80
Val Leu Thr Thr Val Phe Lys Pro Glu Met Lys Glu Ile Pro Gly Gly
85 90 95
Arg Glu Leu Ile Lys Arg Glu Ile Ala Glu Met Gly Pro Trp Thr Ala
100 105 110
Pro Gln Val Thr Val Gly Val Ile Phe Ala Ala Ala Ala Leu Ala Trp
115 120 125
Val Phe Ile Pro Leu Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser Ile
130 135 140
Asn Asp Ser Leu Ile Gly Ile Ala Ala Gly Leu Leu Met Phe Ile Val
145 150 155 160
Pro Ala Asn Phe Lys Thr Gly Glu Arg Ile Leu Asp Trp Arg Thr Ala
165 170 175
Gly Glu Leu Pro Trp Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ser
180 185 190
Leu Ser Ala Met Phe Thr Ser Thr Gly Leu Ser Leu Trp Ile Gly Glu
195 200 205
Leu Ala Lys Gly Leu Asp Ala Leu Pro Ile Phe Ile Leu Ile Phe Ala
210 215 220
Ile Ala Val Leu Val Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Ala
225 230 235 240
Thr Ala Ala Thr Phe Leu Pro Ile Met Gly Gly Val Ala Val Gly Ile
245 250 255
Gly Leu Thr Ala Gly Gly Glu Gln Asn Val Leu Leu Leu Thr Ile Pro
260 265 270
Val Ala Leu Ser Ala Thr Cys Ala Phe Met Leu Pro Val Ala Thr Pro
275 280 285
Pro Asn Ala Ile Ala Phe Gly Ser Gly Tyr Ile Lys Ile Gly Glu Met
290 295 300
Val Lys Gly Gly Leu Trp Leu Asn Ile Ile Ala Val Ile Leu Ile Thr
305 310 315 320
Ile Phe Thr Tyr Phe Val Ala Ile Pro Leu Phe Gly Ile Met Leu
325 330 335
<210> 519
<211> 448
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(448)
<223> FRXA01755
<400> 519
tcgttggctt acatggtcat tgatgaccgg gctgaatatg tgagaaaatc catcccttct 60
ttaagcaagg gagtgaatta cagaaaagga ttgttcagca atg agc aca cct gac 115
Met Ser Thr Pro Asp
1 5
att aaa gaa ggc tcg gca gaa tca ccg ggc gaa gta atg gtc gtt gga 163
Ile Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu Val Met Val Val Gly
10 15 20
gac agg cga gag tgg cgt cga caa gca acc ggc atc att gcc ggc ctc 211
Asp Arg Arg Glu Trp Arg Arg Gln Ala Thr Gly Ile Ile Ala Gly Leu
25 30 35
gtc tta gcc gcc ctg gtc tat ctt ctc ttc ccc tcg aac tcc gtg gaa 259
Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro Ser Asn Ser Val Glu
40 45 50
acc gtc atg caa tcc agt ggc gtc gat cca gaa act gaa tac acc aac 307
Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu Thr Glu Tyr Thr Asn
55 60 65
aac gcg atg cgt ctt act gct gca gtc aca atc ttg atg gca gtg tgg 355
Asn Ala Met Arg Leu Thr Ala Ala Val Thr Ile Leu Met Ala Val Trp
70 75 80 85
tgg atg aca gaa gca atc cca cta gca gca acc gca ctt atc ccg ttg 403
Trp Met Thr Glu Ala Ile Pro Leu Ala Ala Thr Ala Leu Ile Pro Leu
90 95 100
gtt gca ttc cct gct ttc cag gtt gtg gac ttt ggg aag gca gca 448
Val Ala Phe Pro Ala Phe Gln Val Val Asp Phe Gly Lys Ala Ala
105 110 115
<210> 520
<211> 116
<212> PRT
<213> Corynebacterium glutamicum
<400> 520
Met Ser Thr Pro Asp Ile Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu
1 5 10 15
Val Met Val Val Gly Asp Arg Arg Glu Trp Arg Arg Gln Ala Thr Gly
20 25 30
Ile Ile Ala Gly Leu Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro
35 40 45
Ser Asn Ser Val Glu Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu
50 55 60
Thr Glu Tyr Thr Asn Asn Ala Met Arg Leu Thr Ala Ala Val Thr Ile
65 70 75 80
Leu Met Ala Val Trp Trp Met Thr Glu Ala Ile Pro Leu Ala Ala Thr
85 90 95
Ala Leu Ile Pro Leu Val Ala Phe Pro Ala Phe Gln Val Val Asp Phe
100 105 110
Gly Lys Ala Ala
115
<210> 521
<211> 912
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(889)
<223> RXA00269
<400> 521
tgcgatcttg gtggttgtcg ccatgctgct gccgaggtgg cgtgcgaagt tctccaaggc 60
accgaagcct aagcaaccag tagcagtgga ggcttaagac atg tta tcc atc aac 115
Met Leu Ser Ile Asn
1 5
gga att tct aag acg ttc ttc ccc ggc act gtg aat gag cgc cgc gcg 163
Gly Ile Ser Lys Thr Phe Phe Pro Gly Thr Val Asn Glu Arg Arg Ala
10 15 20
ttg cag cag ctc aaa ctc gat atg gct gag ggc gat ttt gtc acc gtc 211
Leu Gln Gln Leu Lys Leu Asp Met Ala Glu Gly Asp Phe Val Thr Val
25 30 35
atc ggt tct aac ggt gcg ggt aaa tcc acg ctg ctc aac gct gtt tct 259
Ile Gly Ser Asn Gly Ala Gly Lys Ser Thr Leu Leu Asn Ala Val Ser
40 45 50
ggc cgt ttg ctt gtt gat tcc ggc gag att tcc atc gac ggc aac aag 307
Gly Arg Leu Leu Val Asp Ser Gly Glu Ile Ser Ile Asp Gly Asn Lys
55 60 65
gta aac aag atg tca gag cac aag cgt gcc cgc tac atc ggc cgc gtt 355
Val Asn Lys Met Ser Glu His Lys Arg Ala Arg Tyr Ile Gly Arg Val
70 75 80 85
ttc cag gat cct ctg gcc ggc acc gcg ccg aat ctc acc att gaa gag 403
Phe Gln Asp Pro Leu Ala Gly Thr Ala Pro Asn Leu Thr Ile Glu Glu
90 95 100
aat ctg gcc atc gcg ttg ctg cgc ggc aag cgc cgt gga ttg ggc ttt 451
Asn Leu Ala Ile Ala Leu Leu Arg Gly Lys Arg Arg Gly Leu Gly Phe
105 110 115
gca ctg acc tcg aag cgc cgt gag caa ttc aag cag gaa ctt gag cgc 499
Ala Leu Thr Ser Lys Arg Arg Glu Gln Phe Lys Gln Glu Leu Glu Arg
120 125 130
ctt gag ctg ggt ctg gaa aac agg ctc act gcc aaa gtt ggt ttg ctc 547
Leu Glu Leu Gly Leu Glu Asn Arg Leu Thr Ala Lys Val Gly Leu Leu
135 140 145
tct ggc ggt cag cgt cag gca ttg tcc ctg ctg atg gct ggt ttt act 595
Ser Gly Gly Gln Arg Gln Ala Leu Ser Leu Leu Met Ala Gly Phe Thr
150 155 160 165
caa cct aaa atc atg ctg ttg gat gag cac acc gca gcg ctt gat cca 643
Gln Pro Lys Ile Met Leu Leu Asp Glu His Thr Ala Ala Leu Asp Pro
170 175 180
cag cgt gca gag ctt gtg acc acc ttg acc gaa aag atc gtg gca gat 691
Gln Arg Ala Glu Leu Val Thr Thr Leu Thr Glu Lys Ile Val Ala Asp
185 190 195
gga aat ctg act acg ctt atg gtc acg cac aac atg gaa cag gca att 739
Gly Asn Leu Thr Thr Leu Met Val Thr His Asn Met Glu Gln Ala Ile
200 205 210
cgc ctg ggc aat cgc ctg atc atg atg cat gaa ggc cag att gtc tac 787
Arg Leu Gly Asn Arg Leu Ile Met Met His Glu Gly Gln Ile Val Tyr
215 220 225
cag gca gat cag gct acc aag tcg aag ttg act gtg cgc gat ttg ctg 835
Gln Ala Asp Gln Ala Thr Lys Ser Lys Leu Thr Val Arg Asp Leu Leu
230 235 240 245
cag gag ttc gcc aac atc aag ggc gca aca ttg tct gac aag gcg ttc 883
Gln Glu Phe Ala Asn Ile Lys Gly Ala Thr Leu Ser Asp Lys Ala Phe
250 255 260
ctc ggc taaaaagagc ttgctttacg acg 912
Leu Gly
<210> 522
<211> 263
<212> PRT
<213> Corynebacterium glutamicum
<400> 522
Met Leu Ser Ile Asn Gly Ile Ser Lys Thr Phe Phe Pro Gly Thr Val
1 5 10 15
Asn Glu Arg Arg Ala Leu Gln Gln Leu Lys Leu Asp Met Ala Glu Gly
20 25 30
Asp Phe Val Thr Val Ile Gly Ser Asn Gly Ala Gly Lys Ser Thr Leu
35 40 45
Leu Asn Ala Val Ser Gly Arg Leu Leu Val Asp Ser Gly Glu Ile Ser
50 55 60
Ile Asp Gly Asn Lys Val Asn Lys Met Ser Glu His Lys Arg Ala Arg
65 70 75 80
Tyr Ile Gly Arg Val Phe Gln Asp Pro Leu Ala Gly Thr Ala Pro Asn
85 90 95
Leu Thr Ile Glu Glu Asn Leu Ala Ile Ala Leu Leu Arg Gly Lys Arg
100 105 110
Arg Gly Leu Gly Phe Ala Leu Thr Ser Lys Arg Arg Glu Gln Phe Lys
115 120 125
Gln Glu Leu Glu Arg Leu Glu Leu Gly Leu Glu Asn Arg Leu Thr Ala
130 135 140
Lys Val Gly Leu Leu Ser Gly Gly Gln Arg Gln Ala Leu Ser Leu Leu
145 150 155 160
Met Ala Gly Phe Thr Gln Pro Lys Ile Met Leu Leu Asp Glu His Thr
165 170 175
Ala Ala Leu Asp Pro Gln Arg Ala Glu Leu Val Thr Thr Leu Thr Glu
180 185 190
Lys Ile Val Ala Asp Gly Asn Leu Thr Thr Leu Met Val Thr His Asn
195 200 205
Met Glu Gln Ala Ile Arg Leu Gly Asn Arg Leu Ile Met Met His Glu
210 215 220
Gly Gln Ile Val Tyr Gln Ala Asp Gln Ala Thr Lys Ser Lys Leu Thr
225 230 235 240
Val Arg Asp Leu Leu Gln Glu Phe Ala Asn Ile Lys Gly Ala Thr Leu
245 250 255
Ser Asp Lys Ala Phe Leu Gly
260
<210> 523
<211> 817
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(817)
<223> RXA00369
<400> 523
ggcgggaaat tacaatcagg catcggcgtt gtcgttgatg tttgcgatta tcggtatcgt 60
ggcgctcgcg ttgacggtgc gcagccagaa ggagttttag gtg tca tcg atc aaa 115
Val Ser Ser Ile Lys
1 5
ttg cgc gat tta agc gtg agc ttc cgc gac gga acc ttc ggg ctg caa 163
Leu Arg Asp Leu Ser Val Ser Phe Arg Asp Gly Thr Phe Gly Leu Gln
10 15 20
gat atc aat ttg aaa att gag ccg gaa gaa ttt gtg gtg ctc atc ggg 211
Asp Ile Asn Leu Lys Ile Glu Pro Glu Glu Phe Val Val Leu Ile Gly
25 30 35
ccg tcg ggg tcc ggt aaa acc acc atg ttg ggc acc atc gcg ggg ttt 259
Pro Ser Gly Ser Gly Lys Thr Thr Met Leu Gly Thr Ile Ala Gly Phe
40 45 50
gtg gag cca agt tcc ggc agt gtg ctc atc gcc ggc gaa gaa atg acg 307
Val Glu Pro Ser Ser Gly Ser Val Leu Ile Ala Gly Glu Glu Met Thr
55 60 65
cat gtc ccg ccg gag cgc cgt cgc atg ggc atg gtg ttt cag cag cat 355
His Val Pro Pro Glu Arg Arg Arg Met Gly Met Val Phe Gln Gln His
70 75 80 85
gcg gtg tgg ccg cat atg tcg gtc gcc aag aat gtg gga tac ccg ctg 403
Ala Val Trp Pro His Met Ser Val Ala Lys Asn Val Gly Tyr Pro Leu
90 95 100
gcg cga agt ggt cag aag ggg gcg tcg ata agc aaa cgc gtg gag cgc 451
Ala Arg Ser Gly Gln Lys Gly Ala Ser Ile Ser Lys Arg Val Glu Arg
105 110 115
acg ctc gcg ctg gtg ggg ctt gag ggg ttc ggc agt cgc aga ccg gcc 499
Thr Leu Ala Leu Val Gly Leu Glu Gly Phe Gly Ser Arg Arg Pro Ala
120 125 130
agc ctg tct ggt ggt caa cgt cag cgg gtg gcg ctt gcg cgc gcc atc 547
Ser Leu Ser Gly Gly Gln Arg Gln Arg Val Ala Leu Ala Arg Ala Ile
135 140 145
atc gcc gac ccc acc gtg ctg ctt ctc gac gag gcc ctc tcc gcc ctc 595
Ile Ala Asp Pro Thr Val Leu Leu Leu Asp Glu Ala Leu Ser Ala Leu
150 155 160 165
gac gaa ccg ctg cga gac gct tta cga cgc gaa ctc gta tct ttg acc 643
Asp Glu Pro Leu Arg Asp Ala Leu Arg Arg Glu Leu Val Ser Leu Thr
170 175 180
cgg cgc gaa ggc ctc act act gtg cac gtg acg cat gac cgc gcc gaa 691
Arg Arg Glu Gly Leu Thr Thr Val His Val Thr His Asp Arg Ala Glu
185 190 195
gcg atc tcc atc gct gac cgc atc gtc gta ctc ggc aac ggt cga atc 739
Ala Ile Ser Ile Ala Asp Arg Ile Val Val Leu Gly Asn Gly Arg Ile
200 205 210
caa cag gta gcc acc cct act gag ctc ctt tcc gcc ccc gct act gcc 787
Gln Gln Val Ala Thr Pro Thr Glu Leu Leu Ser Ala Pro Ala Thr Ala
215 220 225
gat gtt gcc cga ttc atc gtc gac gcc acc 817
Asp Val Ala Arg Phe Ile Val Asp Ala Thr
230 235
<210> 524
<211> 239
<212> PRT
<213> Corynebacterium glutamicum
<400> 524
Val Ser Ser Ile Lys Leu Arg Asp Leu Ser Val Ser Phe Arg Asp Gly
1 5 10 15
Thr Phe Gly Leu Gln Asp Ile Asn Leu Lys Ile Glu Pro Glu Glu Phe
20 25 30
Val Val Leu Ile Gly Pro Ser Gly Ser Gly Lys Thr Thr Met Leu Gly
35 40 45
Thr Ile Ala Gly Phe Val Glu Pro Ser Ser Gly Ser Val Leu Ile Ala
50 55 60
Gly Glu Glu Met Thr His Val Pro Pro Glu Arg Arg Arg Met Gly Met
65 70 75 80
Val Phe Gln Gln His Ala Val Trp Pro His Met Ser Val Ala Lys Asn
85 90 95
Val Gly Tyr Pro Leu Ala Arg Ser Gly Gln Lys Gly Ala Ser Ile Ser
100 105 110
Lys Arg Val Glu Arg Thr Leu Ala Leu Val Gly Leu Glu Gly Phe Gly
115 120 125
Ser Arg Arg Pro Ala Ser Leu Ser Gly Gly Gln Arg Gln Arg Val Ala
130 135 140
Leu Ala Arg Ala Ile Ile Ala Asp Pro Thr Val Leu Leu Leu Asp Glu
145 150 155 160
Ala Leu Ser Ala Leu Asp Glu Pro Leu Arg Asp Ala Leu Arg Arg Glu
165 170 175
Leu Val Ser Leu Thr Arg Arg Glu Gly Leu Thr Thr Val His Val Thr
180 185 190
His Asp Arg Ala Glu Ala Ile Ser Ile Ala Asp Arg Ile Val Val Leu
195 200 205
Gly Asn Gly Arg Ile Gln Gln Val Ala Thr Pro Thr Glu Leu Leu Ser
210 215 220
Ala Pro Ala Thr Ala Asp Val Ala Arg Phe Ile Val Asp Ala Thr
225 230 235
<210> 525
<211> 1653
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1630)
<223> RXA02073
<400> 525
tcattgtttt agaggatggc caattgacca tgatggatac acccagcaac gtttcccagc 60
acaatgcgtt tttccgcacc gctgtgatgg aggaagaaca atg att tcc cga ctt 115
Met Ile Ser Arg Leu
1 5
ctc caa ttg gct aag aaa gta tgg ccg gaa ctt gga gcc tcc acg ctc 163
Leu Gln Leu Ala Lys Lys Val Trp Pro Glu Leu Gly Ala Ser Thr Leu
10 15 20
ctg cga ctg ctc aat cag cta ctc acc gca gca ctc att gtg ttc ccc 211
Leu Arg Leu Leu Asn Gln Leu Leu Thr Ala Ala Leu Ile Val Phe Pro
25 30 35
gcc tgg gtg cta agc cgc aaa cca gac atc tcc ctg ctc gcc gtc gcc 259
Ala Trp Val Leu Ser Arg Lys Pro Asp Ile Ser Leu Leu Ala Val Ala
40 45 50
atc atc atg gcg ctc atc gcg ctg aca gca gct gtc tgt cgc tgg ggt 307
Ile Ile Met Ala Leu Ile Ala Leu Thr Ala Ala Val Cys Arg Trp Gly
55 60 65
gag cag gta tgc ggc cac cgc gct gcc ttt ggg ctg ctt gcc cac atg 355
Glu Gln Val Cys Gly His Arg Ala Ala Phe Gly Leu Leu Ala His Met
70 75 80 85
cgc gtt atg ctt tac gac gcc ctc gtc cac aaa ggt tcc ccc tcg ccg 403
Arg Val Met Leu Tyr Asp Ala Leu Val His Lys Gly Ser Pro Ser Pro
90 95 100
atc cac ggc agc ggt tcg atc atg tct gtt gcc acc cgt gac att aac 451
Ile His Gly Ser Gly Ser Ile Met Ser Val Ala Thr Arg Asp Ile Asn
105 110 115
tcc atc gaa gta ttc ttc gcg cac acc att ggg cct aca gtc acc gca 499
Ser Ile Glu Val Phe Phe Ala His Thr Ile Gly Pro Thr Val Thr Ala
120 125 130
gtg ctg ctc agt gcg gga ggc gtg atc acg ctg gca acg ctc gat ccc 547
Val Leu Leu Ser Ala Gly Gly Val Ile Thr Leu Ala Thr Leu Asp Pro
135 140 145
gtt gct ggt cta att ggt tta ctc ggt gtc ctc atc gcg tgg ttg atc 595
Val Ala Gly Leu Ile Gly Leu Leu Gly Val Leu Ile Ala Trp Leu Ile
150 155 160 165
ccc ttg att gga aaa caa tcc tca agc agt gaa gcc aca tca cgt gga 643
Pro Leu Ile Gly Lys Gln Ser Ser Ser Ser Glu Ala Thr Ser Arg Gly
170 175 180
cac atc gcc cag cac ctc acc gaa gat gcc gcc ggc agg ctt gaa atc 691
His Ile Ala Gln His Leu Thr Glu Asp Ala Ala Gly Arg Leu Glu Ile
185 190 195
aac tca cat gga gcg caa gcc aca cgg tta aat gcg ctc gag gtg aaa 739
Asn Ser His Gly Ala Gln Ala Thr Arg Leu Asn Ala Leu Glu Val Lys
200 205 210
gag caa caa ctg gaa caa gtt gtg acc cga cag ggc ttg atc gtc ggt 787
Glu Gln Gln Leu Glu Gln Val Val Thr Arg Gln Gly Leu Ile Val Gly
215 220 225
atc cgt cag ggc gca gca ctt tta tgg ccg tgg ata tca gct gtg ttg 835
Ile Arg Gln Gly Ala Ala Leu Leu Trp Pro Trp Ile Ser Ala Val Leu
230 235 240 245
ttg gtt gct ctg gtt cct cat gtg ggc att gtt gca gcc gcg att atc 883
Leu Val Ala Leu Val Pro His Val Gly Ile Val Ala Ala Ala Ile Ile
250 255 260
ctg ggc atc tcc cct gcg ttg gat gca gtt gag gga ttt gct cgc acc 931
Leu Gly Ile Ser Pro Ala Leu Asp Ala Val Glu Gly Phe Ala Arg Thr
265 270 275
atg cct acc gcg tta aac agt gcg cag cgg tat ttc cag atc atc gat 979
Met Pro Thr Ala Leu Asn Ser Ala Gln Arg Tyr Phe Gln Ile Ile Asp
280 285 290
gcc cct gtt gct atc gct gaa cct gac gag ccg aag cct ttg ccc aaa 1027
Ala Pro Val Ala Ile Ala Glu Pro Asp Glu Pro Lys Pro Leu Pro Lys
295 300 305
ggc ccg ctt aag ctg cga att tct aga gtt cca gtc agc gca aag ggc 1075
Gly Pro Leu Lys Leu Arg Ile Ser Arg Val Pro Val Ser Ala Lys Gly
310 315 320 325
acc gtg tct tta gag gtt gca gct ggt gaa cac atc ggc atc atc gga 1123
Thr Val Ser Leu Glu Val Ala Ala Gly Glu His Ile Gly Ile Ile Gly
330 335 340
tcc agc ggt agt gga aaa tcc act ttg gcc aaa ctc atc ctc aag ctg 1171
Ser Ser Gly Ser Gly Lys Ser Thr Leu Ala Lys Leu Ile Leu Lys Leu
345 350 355
gcg caa cta cgg tct gga acc atc acc atc ggt ggt gtt gat atc gca 1219
Ala Gln Leu Arg Ser Gly Thr Ile Thr Ile Gly Gly Val Asp Ile Ala
360 365 370
gag gtt tca tcg gcg gag ctt cgc aaa tcc gtc acg ctg gtt gag cag 1267
Glu Val Ser Ser Ala Glu Leu Arg Lys Ser Val Thr Leu Val Glu Gln
375 380 385
aaa tct gtg ctg ttt aga gca agc gtg ctg gag aat tta cgg atg ggc 1315
Lys Ser Val Leu Phe Arg Ala Ser Val Leu Glu Asn Leu Arg Met Gly
390 395 400 405
aat cca gag ctg tct gaa gat gaa gca agg gaa gcc ttg agg ttg gcg 1363
Asn Pro Glu Leu Ser Glu Asp Glu Ala Arg Glu Ala Leu Arg Leu Ala
410 415 420
tcg ata agc gaa ctg cct tta gat gct gac gcc ctg cgc cta tct ggc 1411
Ser Ile Ser Glu Leu Pro Leu Asp Ala Asp Ala Leu Arg Leu Ser Gly
425 430 435
gga cag caa caa cgg ctc tgc ctg gcg cgt gct ttg gca cgc acc cct 1459
Gly Gln Gln Gln Arg Leu Cys Leu Ala Arg Ala Leu Ala Arg Thr Pro
440 445 450
cag gta ctg att gtc gat gaa gcc acc agc cac caa gat gcg ctc aat 1507
Gln Val Leu Ile Val Asp Glu Ala Thr Ser His Gln Asp Ala Leu Asn
455 460 465
caa gcg gat ctt tcc cag act ctg gcc acg ctt aaa gac acc acg gtg 1555
Gln Ala Asp Leu Ser Gln Thr Leu Ala Thr Leu Lys Asp Thr Thr Val
470 475 480 485
atc atc att gcg cac cgc aca gct gca tta acc cat gtg gat cgg ata 1603
Ile Ile Ile Ala His Arg Thr Ala Ala Leu Thr His Val Asp Arg Ile
490 495 500
att gac ctg gaa gaa atc aaa aat ccc tgatccttaa cgcggatcag 1650
Ile Asp Leu Glu Glu Ile Lys Asn Pro
505 510
ggg 1653
<210> 526
<211> 510
<212> PRT
<213> Corynebacterium glutamicum
<400> 526
Met Ile Ser Arg Leu Leu Gln Leu Ala Lys Lys Val Trp Pro Glu Leu
1 5 10 15
Gly Ala Ser Thr Leu Leu Arg Leu Leu Asn Gln Leu Leu Thr Ala Ala
20 25 30
Leu Ile Val Phe Pro Ala Trp Val Leu Ser Arg Lys Pro Asp Ile Ser
35 40 45
Leu Leu Ala Val Ala Ile Ile Met Ala Leu Ile Ala Leu Thr Ala Ala
50 55 60
Val Cys Arg Trp Gly Glu Gln Val Cys Gly His Arg Ala Ala Phe Gly
65 70 75 80
Leu Leu Ala His Met Arg Val Met Leu Tyr Asp Ala Leu Val His Lys
85 90 95
Gly Ser Pro Ser Pro Ile His Gly Ser Gly Ser Ile Met Ser Val Ala
100 105 110
Thr Arg Asp Ile Asn Ser Ile Glu Val Phe Phe Ala His Thr Ile Gly
115 120 125
Pro Thr Val Thr Ala Val Leu Leu Ser Ala Gly Gly Val Ile Thr Leu
130 135 140
Ala Thr Leu Asp Pro Val Ala Gly Leu Ile Gly Leu Leu Gly Val Leu
145 150 155 160
Ile Ala Trp Leu Ile Pro Leu Ile Gly Lys Gln Ser Ser Ser Ser Glu
165 170 175
Ala Thr Ser Arg Gly His Ile Ala Gln His Leu Thr Glu Asp Ala Ala
180 185 190
Gly Arg Leu Glu Ile Asn Ser His Gly Ala Gln Ala Thr Arg Leu Asn
195 200 205
Ala Leu Glu Val Lys Glu Gln Gln Leu Glu Gln Val Val Thr Arg Gln
210 215 220
Gly Leu Ile Val Gly Ile Arg Gln Gly Ala Ala Leu Leu Trp Pro Trp
225 230 235 240
Ile Ser Ala Val Leu Leu Val Ala Leu Val Pro His Val Gly Ile Val
245 250 255
Ala Ala Ala Ile Ile Leu Gly Ile Ser Pro Ala Leu Asp Ala Val Glu
260 265 270
Gly Phe Ala Arg Thr Met Pro Thr Ala Leu Asn Ser Ala Gln Arg Tyr
275 280 285
Phe Gln Ile Ile Asp Ala Pro Val Ala Ile Ala Glu Pro Asp Glu Pro
290 295 300
Lys Pro Leu Pro Lys Gly Pro Leu Lys Leu Arg Ile Ser Arg Val Pro
305 310 315 320
Val Ser Ala Lys Gly Thr Val Ser Leu Glu Val Ala Ala Gly Glu His
325 330 335
Ile Gly Ile Ile Gly Ser Ser Gly Ser Gly Lys Ser Thr Leu Ala Lys
340 345 350
Leu Ile Leu Lys Leu Ala Gln Leu Arg Ser Gly Thr Ile Thr Ile Gly
355 360 365
Gly Val Asp Ile Ala Glu Val Ser Ser Ala Glu Leu Arg Lys Ser Val
370 375 380
Thr Leu Val Glu Gln Lys Ser Val Leu Phe Arg Ala Ser Val Leu Glu
385 390 395 400
Asn Leu Arg Met Gly Asn Pro Glu Leu Ser Glu Asp Glu Ala Arg Glu
405 410 415
Ala Leu Arg Leu Ala Ser Ile Ser Glu Leu Pro Leu Asp Ala Asp Ala
420 425 430
Leu Arg Leu Ser Gly Gly Gln Gln Gln Arg Leu Cys Leu Ala Arg Ala
435 440 445
Leu Ala Arg Thr Pro Gln Val Leu Ile Val Asp Glu Ala Thr Ser His
450 455 460
Gln Asp Ala Leu Asn Gln Ala Asp Leu Ser Gln Thr Leu Ala Thr Leu
465 470 475 480
Lys Asp Thr Thr Val Ile Ile Ile Ala His Arg Thr Ala Ala Leu Thr
485 490 495
His Val Asp Arg Ile Ile Asp Leu Glu Glu Ile Lys Asn Pro
500 505 510
<210> 527
<211> 1142
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(1119)
<223> RXA01399
<400> 527
att ctc agc ccc gca acc gca ctt gtc ctg gcg att gga ttg att gct 48
Ile Leu Ser Pro Ala Thr Ala Leu Val Leu Ala Ile Gly Leu Ile Ala
1 5 10 15
gct gca att atc cct ccc ctg ctt gct gct cgc gga gtt aaa aca gcc 96
Ala Ala Ile Ile Pro Pro Leu Leu Ala Ala Arg Gly Val Lys Thr Ala
20 25 30
gaa gcc cgg cgc gct gaa tcc agc gaa gcc tac ttg agt tcc ttg gat 144
Glu Ala Arg Arg Ala Glu Ser Ser Glu Ala Tyr Leu Ser Ser Leu Asp
35 40 45
cag gtg ctg tcc aac cag gcg gcg ctt cgt gtt cgt ggt gaa atg ccg 192
Gln Val Leu Ser Asn Gln Ala Ala Leu Arg Val Arg Gly Glu Met Pro
50 55 60
gcc gct ctg tcc aag gcg gat gtg gct gcg cgt tcc tat tct tct tca 240
Ala Ala Leu Ser Lys Ala Asp Val Ala Ala Arg Ser Tyr Ser Ser Ser
65 70 75 80
ctg gag gca ggc gcg aaa gac act gcc att ggc gca gcg agt tcc ctg 288
Leu Glu Ala Gly Ala Lys Asp Thr Ala Ile Gly Ala Ala Ser Ser Leu
85 90 95
tgg att cac ggt ttc act gtc att ggt gtg ctc atg gtt tcc gcg tca 336
Trp Ile His Gly Phe Thr Val Ile Gly Val Leu Met Val Ser Ala Ser
100 105 110
ctg tat gca gat gga agc cat tca ccg cag tgg ttt ggt gtg ttg gtg 384
Leu Tyr Ala Asp Gly Ser His Ser Pro Gln Trp Phe Gly Val Leu Val
115 120 125
ctg ctt tca ctc gca gct ttc gag gct gtc tct gtt ctc ccc gat gct 432
Leu Leu Ser Leu Ala Ala Phe Glu Ala Val Ser Val Leu Pro Asp Ala
130 135 140
gcg att gct cgt acc cgc gcc gca gat gcc acc agg agg ctt gcg gaa 480
Ala Ile Ala Arg Thr Arg Ala Ala Asp Ala Thr Arg Arg Leu Ala Glu
145 150 155 160
atc tcg gcg ctg cca gaa tct gtc tct ctt gag ctt cgc acg gcc tct 528
Ile Ser Ala Leu Pro Glu Ser Val Ser Leu Glu Leu Arg Thr Ala Ser
165 170 175
gac cag ccc gta tta cgc gcc gag aat cta gtt tat gga tgg gac agc 576
Asp Gln Pro Val Leu Arg Ala Glu Asn Leu Val Tyr Gly Trp Asp Ser
180 185 190
gac cta ggc acg agc aac ctg gat ctc acc ttt ggt tca cga cat gaa 624
Asp Leu Gly Thr Ser Asn Leu Asp Leu Thr Phe Gly Ser Arg His Glu
195 200 205
atc atc gca ccc tct gga act ggc aaa acg acc ctg ctg ctc aca ctt 672
Ile Ile Ala Pro Ser Gly Thr Gly Lys Thr Thr Leu Leu Leu Thr Leu
210 215 220
gcg ggg ctg ttg gaa cct cgt gga ggc caa gtg ctt atc gac ggc acc 720
Ala Gly Leu Leu Glu Pro Arg Gly Gly Gln Val Leu Ile Asp Gly Thr
225 230 235 240
aat cct tcc gag ttg aaa aac gcc gtg ctg ttc agt cca gaa gat gcc 768
Asn Pro Ser Glu Leu Lys Asn Ala Val Leu Phe Ser Pro Glu Asp Ala
245 250 255
cac att ttt gcc acc act gtc cga gat aac tta gca ctc gga gca ccg 816
His Ile Phe Ala Thr Thr Val Arg Asp Asn Leu Ala Leu Gly Ala Pro
260 265 270
gaa gca acc gac gcg gaa atg aca tcg atc ctg gaa cat gtt ggt ttg 864
Glu Ala Thr Asp Ala Glu Met Thr Ser Ile Leu Glu His Val Gly Leu
275 280 285
tca gag tgg gtt caa ggt tta ccc gat ggt ctt ggc act gtc ctt gat 912
Ser Glu Trp Val Gln Gly Leu Pro Asp Gly Leu Gly Thr Val Leu Asp
290 295 300
tca ggt gcc gat agt ctc tcg gga ggt cag cgc cgc cgc ctg ctc ctt 960
Ser Gly Ala Asp Ser Leu Ser Gly Gly Gln Arg Arg Arg Leu Leu Leu
305 310 315 320
gcc cgc gta cta cta agt gat gca cca att ctg ctt ttg gat gaa ccc 1008
Ala Arg Val Leu Leu Ser Asp Ala Pro Ile Leu Leu Leu Asp Glu Pro
325 330 335
acc gag cac ctc gac act gca ggc tcc tct gaa atc ttg tct atg ctg 1056
Thr Glu His Leu Asp Thr Ala Gly Ser Ser Glu Ile Leu Ser Met Leu
340 345 350
gcc tcc gat gaa ctc cct ggt aaa aga gct agg aga acc gta gtg att 1104
Ala Ser Asp Glu Leu Pro Gly Lys Arg Ala Arg Arg Thr Val Val Ile
355 360 365
gtg agg cat gtg agg taattttgcc ccgctgtctt ctg 1142
Val Arg His Val Arg
370
<210> 528
<211> 373
<212> PRT
<213> Corynebacterium glutamicum
<400> 528
Ile Leu Ser Pro Ala Thr Ala Leu Val Leu Ala Ile Gly Leu Ile Ala
1 5 10 15
Ala Ala Ile Ile Pro Pro Leu Leu Ala Ala Arg Gly Val Lys Thr Ala
20 25 30
Glu Ala Arg Arg Ala Glu Ser Ser Glu Ala Tyr Leu Ser Ser Leu Asp
35 40 45
Gln Val Leu Ser Asn Gln Ala Ala Leu Arg Val Arg Gly Glu Met Pro
50 55 60
Ala Ala Leu Ser Lys Ala Asp Val Ala Ala Arg Ser Tyr Ser Ser Ser
65 70 75 80
Leu Glu Ala Gly Ala Lys Asp Thr Ala Ile Gly Ala Ala Ser Ser Leu
85 90 95
Trp Ile His Gly Phe Thr Val Ile Gly Val Leu Met Val Ser Ala Ser
100 105 110
Leu Tyr Ala Asp Gly Ser His Ser Pro Gln Trp Phe Gly Val Leu Val
115 120 125
Leu Leu Ser Leu Ala Ala Phe Glu Ala Val Ser Val Leu Pro Asp Ala
130 135 140
Ala Ile Ala Arg Thr Arg Ala Ala Asp Ala Thr Arg Arg Leu Ala Glu
145 150 155 160
Ile Ser Ala Leu Pro Glu Ser Val Ser Leu Glu Leu Arg Thr Ala Ser
165 170 175
Asp Gln Pro Val Leu Arg Ala Glu Asn Leu Val Tyr Gly Trp Asp Ser
180 185 190
Asp Leu Gly Thr Ser Asn Leu Asp Leu Thr Phe Gly Ser Arg His Glu
195 200 205
Ile Ile Ala Pro Ser Gly Thr Gly Lys Thr Thr Leu Leu Leu Thr Leu
210 215 220
Ala Gly Leu Leu Glu Pro Arg Gly Gly Gln Val Leu Ile Asp Gly Thr
225 230 235 240
Asn Pro Ser Glu Leu Lys Asn Ala Val Leu Phe Ser Pro Glu Asp Ala
245 250 255
His Ile Phe Ala Thr Thr Val Arg Asp Asn Leu Ala Leu Gly Ala Pro
260 265 270
Glu Ala Thr Asp Ala Glu Met Thr Ser Ile Leu Glu His Val Gly Leu
275 280 285
Ser Glu Trp Val Gln Gly Leu Pro Asp Gly Leu Gly Thr Val Leu Asp
290 295 300
Ser Gly Ala Asp Ser Leu Ser Gly Gly Gln Arg Arg Arg Leu Leu Leu
305 310 315 320
Ala Arg Val Leu Leu Ser Asp Ala Pro Ile Leu Leu Leu Asp Glu Pro
325 330 335
Thr Glu His Leu Asp Thr Ala Gly Ser Ser Glu Ile Leu Ser Met Leu
340 345 350
Ala Ser Asp Glu Leu Pro Gly Lys Arg Ala Arg Arg Thr Val Val Ile
355 360 365
Val Arg His Val Arg
370
<210> 529
<211> 1368
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1345)
<223> RXA01339
<400> 529
gagaaggcgg aaccgaagga atcgaagaat atctctccgt gcgttacctc gctttgccgt 60
gacacatgag ctgtccggtg aataacccga aggaaaaaac atg act acc gaa tca 115
Met Thr Thr Glu Ser
1 5
ata gtt gcg cac aat gct gca ggt aca gca cct cag aat gtg tcc tct 163
Ile Val Ala His Asn Ala Ala Gly Thr Ala Pro Gln Asn Val Ser Ser
10 15 20
gct aag aag aag tac ctc agc gtt gcc caa ggc gtt gcc ctt atc tac 211
Ala Lys Lys Lys Tyr Leu Ser Val Ala Gln Gly Val Ala Leu Ile Tyr
25 30 35
gga acc aac atc ggc gcc ggt gtg ctc agc ctc cca tac gct gcc cgc 259
Gly Thr Asn Ile Gly Ala Gly Val Leu Ser Leu Pro Tyr Ala Ala Arg
40 45 50
aac ggt ggt ttc ctc gcc ctg gtt gtt gcc ctg ctc att gcg gga aca 307
Asn Gly Gly Phe Leu Ala Leu Val Val Ala Leu Leu Ile Ala Gly Thr
55 60 65
ctg acc acc atc tcc atg ctc tac atc gcc gaa gta tcc ctg cgc acc 355
Leu Thr Thr Ile Ser Met Leu Tyr Ile Ala Glu Val Ser Leu Arg Thr
70 75 80 85
aag aag cca ctg cag ctt tcc ggc ctg gca gaa aaa tac ctg ggg cag 403
Lys Lys Pro Leu Gln Leu Ser Gly Leu Ala Glu Lys Tyr Leu Gly Gln
90 95 100
tgg ggc cgc tgg ctg gtg ttc att gcc att gtg gtc aac agc gtg ggt 451
Trp Gly Arg Trp Leu Val Phe Ile Ala Ile Val Val Asn Ser Val Gly
105 110 115
gca ctg att gcc tac gca tca gga tcc ggc att ttg ata ggc aac ctc 499
Ala Leu Ile Ala Tyr Ala Ser Gly Ser Gly Ile Leu Ile Gly Asn Leu
120 125 130
acc ggc ctg cca cca atc gtg ggc acc ctt gga ttc ttt gtt tta ggc 547
Thr Gly Leu Pro Pro Ile Val Gly Thr Leu Gly Phe Phe Val Leu Gly
135 140 145
acc ttg atc atg tgg aaa ggc ctg cac acg gca agc ttc gtg gag gca 595
Thr Leu Ile Met Trp Lys Gly Leu His Thr Ala Ser Phe Val Glu Ala
150 155 160 165
ttg atc acc act ggc atg gca acg atc atc atc gtg ctg tgt gga tgg 643
Leu Ile Thr Thr Gly Met Ala Thr Ile Ile Ile Val Leu Cys Gly Trp
170 175 180
aca gtg ctt ggc cct gga att tcc gca gac aac ctg atc gtg ttc cac 691
Thr Val Leu Gly Pro Gly Ile Ser Ala Asp Asn Leu Ile Val Phe His
185 190 195
cca ttc ttc atc gtt ccg atc atg aac ctc gcg gtc ttt acc ttc ctt 739
Pro Phe Phe Ile Val Pro Ile Met Asn Leu Ala Val Phe Thr Phe Leu
200 205 210
gcc caa tat gtg gtt cca gaa atc gca cga gga gtt aac cct gcc acc 787
Ala Gln Tyr Val Val Pro Glu Ile Ala Arg Gly Val Asn Pro Ala Thr
215 220 225
ccg aag gca gtg cca cgc gcg atc atc atc ggc atg gtc gca act ggt 835
Pro Lys Ala Val Pro Arg Ala Ile Ile Ile Gly Met Val Ala Thr Gly
230 235 240 245
gtc acc ctg gca gct gta cca ttc gcg gca cta ggg ctt ctg ggc aca 883
Val Thr Leu Ala Ala Val Pro Phe Ala Ala Leu Gly Leu Leu Gly Thr
250 255 260
ggc gtc agt gaa gtt gtc acc atc tcc tgg ggc gaa gca ctc gcc cca 931
Gly Val Ser Glu Val Val Thr Ile Ser Trp Gly Glu Ala Leu Ala Pro
265 270 275
gtg gcc tat tac atg gcc aat gcc ttc gca cta ttg gcc atg ttc act 979
Val Ala Tyr Tyr Met Ala Asn Ala Phe Ala Leu Leu Ala Met Phe Thr
280 285 290
tca ttc atc gcc att gga ttc acc gcg atg cgc aac gta cta gat att 1027
Ser Phe Ile Ala Ile Gly Phe Thr Ala Met Arg Asn Val Leu Asp Ile
295 300 305
ggc cac tgg cca caa cac gga tgg cag cga tcc gtt gct gtc gga cta 1075
Gly His Trp Pro Gln His Gly Trp Gln Arg Ser Val Ala Val Gly Leu
310 315 320 325
act gtt ctt cca cca ctg gca att tca ctt gcg gga tta ggc gga ttc 1123
Thr Val Leu Pro Pro Leu Ala Ile Ser Leu Ala Gly Leu Gly Gly Phe
330 335 340
gtg gca gca ctg agc tac gcc gga gga ttt gcc gga gca atc atg tcc 1171
Val Ala Ala Leu Ser Tyr Ala Gly Gly Phe Ala Gly Ala Ile Met Ser
345 350 355
atc atc ccc gtg ctg ttg ctg cgc aac tcc cgc aag agt ggc gac caa 1219
Ile Ile Pro Val Leu Leu Leu Arg Asn Ser Arg Lys Ser Gly Asp Gln
360 365 370
gaa cca gtg tgg aaa gcc acc tgg caa gcg cac ccc atc ttc cag atc 1267
Glu Pro Val Trp Lys Ala Thr Trp Gln Ala His Pro Ile Phe Gln Ile
375 380 385
ctg ttg att gtg gtg tac tcc ctg gcg ttt gtg tac tcg gtt ctc gcg 1315
Leu Leu Ile Val Val Tyr Ser Leu Ala Phe Val Tyr Ser Val Leu Ala
390 395 400 405
atc gtc gga tta atg cct gcg ggt tgg gca tagtcacttc ctgttgtggc 1365
Ile Val Gly Leu Met Pro Ala Gly Trp Ala
410 415
tgc 1368
<210> 530
<211> 415
<212> PRT
<213> Corynebacterium glutamicum
<400> 530
Met Thr Thr Glu Ser Ile Val Ala His Asn Ala Ala Gly Thr Ala Pro
1 5 10 15
Gln Asn Val Ser Ser Ala Lys Lys Lys Tyr Leu Ser Val Ala Gln Gly
20 25 30
Val Ala Leu Ile Tyr Gly Thr Asn Ile Gly Ala Gly Val Leu Ser Leu
35 40 45
Pro Tyr Ala Ala Arg Asn Gly Gly Phe Leu Ala Leu Val Val Ala Leu
50 55 60
Leu Ile Ala Gly Thr Leu Thr Thr Ile Ser Met Leu Tyr Ile Ala Glu
65 70 75 80
Val Ser Leu Arg Thr Lys Lys Pro Leu Gln Leu Ser Gly Leu Ala Glu
85 90 95
Lys Tyr Leu Gly Gln Trp Gly Arg Trp Leu Val Phe Ile Ala Ile Val
100 105 110
Val Asn Ser Val Gly Ala Leu Ile Ala Tyr Ala Ser Gly Ser Gly Ile
115 120 125
Leu Ile Gly Asn Leu Thr Gly Leu Pro Pro Ile Val Gly Thr Leu Gly
130 135 140
Phe Phe Val Leu Gly Thr Leu Ile Met Trp Lys Gly Leu His Thr Ala
145 150 155 160
Ser Phe Val Glu Ala Leu Ile Thr Thr Gly Met Ala Thr Ile Ile Ile
165 170 175
Val Leu Cys Gly Trp Thr Val Leu Gly Pro Gly Ile Ser Ala Asp Asn
180 185 190
Leu Ile Val Phe His Pro Phe Phe Ile Val Pro Ile Met Asn Leu Ala
195 200 205
Val Phe Thr Phe Leu Ala Gln Tyr Val Val Pro Glu Ile Ala Arg Gly
210 215 220
Val Asn Pro Ala Thr Pro Lys Ala Val Pro Arg Ala Ile Ile Ile Gly
225 230 235 240
Met Val Ala Thr Gly Val Thr Leu Ala Ala Val Pro Phe Ala Ala Leu
245 250 255
Gly Leu Leu Gly Thr Gly Val Ser Glu Val Val Thr Ile Ser Trp Gly
260 265 270
Glu Ala Leu Ala Pro Val Ala Tyr Tyr Met Ala Asn Ala Phe Ala Leu
275 280 285
Leu Ala Met Phe Thr Ser Phe Ile Ala Ile Gly Phe Thr Ala Met Arg
290 295 300
Asn Val Leu Asp Ile Gly His Trp Pro Gln His Gly Trp Gln Arg Ser
305 310 315 320
Val Ala Val Gly Leu Thr Val Leu Pro Pro Leu Ala Ile Ser Leu Ala
325 330 335
Gly Leu Gly Gly Phe Val Ala Ala Leu Ser Tyr Ala Gly Gly Phe Ala
340 345 350
Gly Ala Ile Met Ser Ile Ile Pro Val Leu Leu Leu Arg Asn Ser Arg
355 360 365
Lys Ser Gly Asp Gln Glu Pro Val Trp Lys Ala Thr Trp Gln Ala His
370 375 380
Pro Ile Phe Gln Ile Leu Leu Ile Val Val Tyr Ser Leu Ala Phe Val
385 390 395 400
Tyr Ser Val Leu Ala Ile Val Gly Leu Met Pro Ala Gly Trp Ala
405 410 415
<210> 531
<211> 1452
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1429)
<223> RXA02527
<400> 531
attggagcaa tcttttaatc aagttgggaa ttccagcgtt gattgtggtt gccatgtggt 60
ttgcccgcac cctgaagcac tcacggatca agcgtggcgg atg ttt ggc ctg ttc 115
Met Phe Gly Leu Phe
1 5
atc gcg acg att gtg gcg att att ctc aag cca atg cca atg ggt gcc 163
Ile Ala Thr Ile Val Ala Ile Ile Leu Lys Pro Met Pro Met Gly Ala
10 15 20
gtg aca att atc ggc atg atc gcc gcg gtg ttg act ggt ttg gtg ccg 211
Val Thr Ile Ile Gly Met Ile Ala Ala Val Leu Thr Gly Leu Val Pro
25 30 35
ttg acg gcg tct tct gat gat ccc ggc gcg gtg tat ggc ctt att ggt 259
Leu Thr Ala Ser Ser Asp Asp Pro Gly Ala Val Tyr Gly Leu Ile Gly
40 45 50
ttc agt aac ggc acc att tgg ctg att gtg atg gcg ttc ctg att tcg 307
Phe Ser Asn Gly Thr Ile Trp Leu Ile Val Met Ala Phe Leu Ile Ser
55 60 65
cgt gga ttc atc aag acg ggg ctt gga cgt cga ata gcg ttg ttc ttt 355
Arg Gly Phe Ile Lys Thr Gly Leu Gly Arg Arg Ile Ala Leu Phe Phe
70 75 80 85
gtg tct aaa gtc ggc gga aaa atg ctg ggt gtg acc tat ggt ttg gcg 403
Val Ser Lys Val Gly Gly Lys Met Leu Gly Val Thr Tyr Gly Leu Ala
90 95 100
ctc gct gat ttg gtg ttg gct cct gcg att cca tca gca act gcc cga 451
Leu Ala Asp Leu Val Leu Ala Pro Ala Ile Pro Ser Ala Thr Ala Arg
105 110 115
ggt ggt ggc att atg gct ccg att atg aag tcg gtg gca ttg act tat 499
Gly Gly Gly Ile Met Ala Pro Ile Met Lys Ser Val Ala Leu Thr Tyr
120 125 130
gat tcc act cct ggc cca act cgt cgc agg gct ggc gcg ttc ttg gcg 547
Asp Ser Thr Pro Gly Pro Thr Arg Arg Arg Ala Gly Ala Phe Leu Ala
135 140 145
ctg aat gtg gga cag gta aat gcg att acg tgc gcg atg ttt cta act 595
Leu Asn Val Gly Gln Val Asn Ala Ile Thr Cys Ala Met Phe Leu Thr
150 155 160 165
gca atg gca gga aac ccc ttg atc gcc tct ttg gct tcg cag atg gat 643
Ala Met Ala Gly Asn Pro Leu Ile Ala Ser Leu Ala Ser Gln Met Asp
170 175 180
gtc aat atc acg tgg aca aac tgg gct gtg ggt gcg att gtg cct ggt 691
Val Asn Ile Thr Trp Thr Asn Trp Ala Val Gly Ala Ile Val Pro Gly
185 190 195
ctg gtg gcg ctt att gtg gtg ccg tgg gtg gta tac aag atc tat cca 739
Leu Val Ala Leu Ile Val Val Pro Trp Val Val Tyr Lys Ile Tyr Pro
200 205 210
cct gag ttg aag gac acc cct gag gtc aag aaa atg gct tct gat gag 787
Pro Glu Leu Lys Asp Thr Pro Glu Val Lys Lys Met Ala Ser Asp Glu
215 220 225
ctc aag caa ttg ggt ggg ttt act tat ggt gag aag gtg ctg gcg gga 835
Leu Lys Gln Leu Gly Gly Phe Thr Tyr Gly Glu Lys Val Leu Ala Gly
230 235 240 245
acc ttt gtt gtg ttg ctg ctg ctc tgg aca ggt ggc gat ttg gtc ttg 883
Thr Phe Val Val Leu Leu Leu Leu Trp Thr Gly Gly Asp Leu Val Leu
250 255 260
gga atc tcg gca act acc acc gct ttc gtt ggc gtc atc atc ttg cta 931
Gly Ile Ser Ala Thr Thr Thr Ala Phe Val Gly Val Ile Ile Leu Leu
265 270 275
gtg gct cac gtg ctg acg tgg gag gac atc att caa gaa aag act gcg 979
Val Ala His Val Leu Thr Trp Glu Asp Ile Ile Gln Glu Lys Thr Ala
280 285 290
tgg gac acc atg gtg tgg ttc gcg gtg cta tac atg atg gca aca gcg 1027
Trp Asp Thr Met Val Trp Phe Ala Val Leu Tyr Met Met Ala Thr Ala
295 300 305
tta tcg cag tac gga ttc atc gca tgg atc tct gag gta att gct tcc 1075
Leu Ser Gln Tyr Gly Phe Ile Ala Trp Ile Ser Glu Val Ile Ala Ser
310 315 320 325
agt ttg ggt ggc atg aac tgg gtc gtt gct ttg gtt gtg ttg gtg ctg 1123
Ser Leu Gly Gly Met Asn Trp Val Val Ala Leu Val Val Leu Val Leu
330 335 340
att tac ttc ttc agt cac tat ttc ttt gcc tcg gca aca gcg cat att 1171
Ile Tyr Phe Phe Ser His Tyr Phe Phe Ala Ser Ala Thr Ala His Ile
345 350 355
tct gcg atg tac ttg gcc ttc ctg ggt gct gcg att gcg att ggt gca 1219
Ser Ala Met Tyr Leu Ala Phe Leu Gly Ala Ala Ile Ala Ile Gly Ala
360 365 370
ccc ccg ttg atg gcg gcc ctg gtg ttg gcg tac acc tcc aat ttg ttc 1267
Pro Pro Leu Met Ala Ala Leu Val Leu Ala Tyr Thr Ser Asn Leu Phe
375 380 385
tct tca ctc act cag tat tct ggt ggt cct tcg cca aca ttg ttt ggt 1315
Ser Ser Leu Thr Gln Tyr Ser Gly Gly Pro Ser Pro Thr Leu Phe Gly
390 395 400 405
ttg aac tac atc acg gtg ggt gag tgg tgg cgg acc tcg gca att gct 1363
Leu Asn Tyr Ile Thr Val Gly Glu Trp Trp Arg Thr Ser Ala Ile Ala
410 415 420
ggc gcg gta tcg att aca atc tgg ttg gtt atc ggt ggt ttg tgg atg 1411
Gly Ala Val Ser Ile Thr Ile Trp Leu Val Ile Gly Gly Leu Trp Met
425 430 435
aat gtc atc gga ctc tgg taatcgaaaa ttaaaggtaa ggg 1452
Asn Val Ile Gly Leu Trp
440
<210> 532
<211> 443
<212> PRT
<213> Corynebacterium glutamicum
<400> 532
Met Phe Gly Leu Phe Ile Ala Thr Ile Val Ala Ile Ile Leu Lys Pro
1 5 10 15
Met Pro Met Gly Ala Val Thr Ile Ile Gly Met Ile Ala Ala Val Leu
20 25 30
Thr Gly Leu Val Pro Leu Thr Ala Ser Ser Asp Asp Pro Gly Ala Val
35 40 45
Tyr Gly Leu Ile Gly Phe Ser Asn Gly Thr Ile Trp Leu Ile Val Met
50 55 60
Ala Phe Leu Ile Ser Arg Gly Phe Ile Lys Thr Gly Leu Gly Arg Arg
65 70 75 80
Ile Ala Leu Phe Phe Val Ser Lys Val Gly Gly Lys Met Leu Gly Val
85 90 95
Thr Tyr Gly Leu Ala Leu Ala Asp Leu Val Leu Ala Pro Ala Ile Pro
100 105 110
Ser Ala Thr Ala Arg Gly Gly Gly Ile Met Ala Pro Ile Met Lys Ser
115 120 125
Val Ala Leu Thr Tyr Asp Ser Thr Pro Gly Pro Thr Arg Arg Arg Ala
130 135 140
Gly Ala Phe Leu Ala Leu Asn Val Gly Gln Val Asn Ala Ile Thr Cys
145 150 155 160
Ala Met Phe Leu Thr Ala Met Ala Gly Asn Pro Leu Ile Ala Ser Leu
165 170 175
Ala Ser Gln Met Asp Val Asn Ile Thr Trp Thr Asn Trp Ala Val Gly
180 185 190
Ala Ile Val Pro Gly Leu Val Ala Leu Ile Val Val Pro Trp Val Val
195 200 205
Tyr Lys Ile Tyr Pro Pro Glu Leu Lys Asp Thr Pro Glu Val Lys Lys
210 215 220
Met Ala Ser Asp Glu Leu Lys Gln Leu Gly Gly Phe Thr Tyr Gly Glu
225 230 235 240
Lys Val Leu Ala Gly Thr Phe Val Val Leu Leu Leu Leu Trp Thr Gly
245 250 255
Gly Asp Leu Val Leu Gly Ile Ser Ala Thr Thr Thr Ala Phe Val Gly
260 265 270
Val Ile Ile Leu Leu Val Ala His Val Leu Thr Trp Glu Asp Ile Ile
275 280 285
Gln Glu Lys Thr Ala Trp Asp Thr Met Val Trp Phe Ala Val Leu Tyr
290 295 300
Met Met Ala Thr Ala Leu Ser Gln Tyr Gly Phe Ile Ala Trp Ile Ser
305 310 315 320
Glu Val Ile Ala Ser Ser Leu Gly Gly Met Asn Trp Val Val Ala Leu
325 330 335
Val Val Leu Val Leu Ile Tyr Phe Phe Ser His Tyr Phe Phe Ala Ser
340 345 350
Ala Thr Ala His Ile Ser Ala Met Tyr Leu Ala Phe Leu Gly Ala Ala
355 360 365
Ile Ala Ile Gly Ala Pro Pro Leu Met Ala Ala Leu Val Leu Ala Tyr
370 375 380
Thr Ser Asn Leu Phe Ser Ser Leu Thr Gln Tyr Ser Gly Gly Pro Ser
385 390 395 400
Pro Thr Leu Phe Gly Leu Asn Tyr Ile Thr Val Gly Glu Trp Trp Arg
405 410 415
Thr Ser Ala Ile Ala Gly Ala Val Ser Ile Thr Ile Trp Leu Val Ile
420 425 430
Gly Gly Leu Trp Met Asn Val Ile Gly Leu Trp
435 440
<210> 533
<211> 1968
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1945)
<223> RXN00298
<400> 533
tttagacaag ttctggttaa aattcttcat gaaggtgaga atctgggaat ttctcggtac 60
tctttcagat tcgtagttat ccactgattg gaagaatgag atg agc tca aat ata 115
Met Ser Ser Asn Ile
1 5
gct atc acg acc gag cct gaa ggg aaa aat aaa aag ggt ctc aaa tca 163
Ala Ile Thr Thr Glu Pro Glu Gly Lys Asn Lys Lys Gly Leu Lys Ser
10 15 20
gac ccg ttc att ttt tcc att tct gtc ggt ttt atc gtg gtg ttt gtc 211
Asp Pro Phe Ile Phe Ser Ile Ser Val Gly Phe Ile Val Val Phe Val
25 30 35
atc gcc aca att gcg cta ggc gag aaa gct cga aca acc ttt tcc gcg 259
Ile Ala Thr Ile Ala Leu Gly Glu Lys Ala Arg Thr Thr Phe Ser Ala
40 45 50
att gcc ggc tgg ctc tta gaa aat tta ggg tgg atg tat atc ggg ggt 307
Ile Ala Gly Trp Leu Leu Glu Asn Leu Gly Trp Met Tyr Ile Gly Gly
55 60 65
gtc tcc ttg gtt ttc att ttc ctc atg ggt atc ttt gcg tcc cgg tat 355
Val Ser Leu Val Phe Ile Phe Leu Met Gly Ile Phe Ala Ser Arg Tyr
70 75 80 85
ggc cgg gta aaa ctt ggt gat gac gat gat gac ccc gag cac acc cta 403
Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp Pro Glu His Thr Leu
90 95 100
atc gtg tgg ttc tgt atg ctt ttt gct ggc ggt gtc ggt gca gtc tta 451
Ile Val Trp Phe Cys Met Leu Phe Ala Gly Gly Val Gly Ala Val Leu
105 110 115
atg ttt tgg ggt gtt gcc gaa ccg att aac cac gcg ttc aac gtg cca 499
Met Phe Trp Gly Val Ala Glu Pro Ile Asn His Ala Phe Asn Val Pro
120 125 130
atg gct aat gaa gaa tcc atg agt gaa gcc gca att gtg cag gct ttt 547
Met Ala Asn Glu Glu Ser Met Ser Glu Ala Ala Ile Val Gln Ala Phe
135 140 145
gct tat act ttc tat cac ttc ggt att cac atg tgg gta atc atg gca 595
Ala Tyr Thr Phe Tyr His Phe Gly Ile His Met Trp Val Ile Met Ala
150 155 160 165
ctc cca gga tta tca ttg gga tac ttt att tac aaa cgt aag cta cct 643
Leu Pro Gly Leu Ser Leu Gly Tyr Phe Ile Tyr Lys Arg Lys Leu Pro
170 175 180
ccc cgt cta tcc tct gtg ttt tct ccg atc ttg ggt aag cac att tat 691
Pro Arg Leu Ser Ser Val Phe Ser Pro Ile Leu Gly Lys His Ile Tyr
185 190 195
tcc aca ccc ggc aag ctc atc gat gta ctg gcc atc gta ggc acc acg 739
Ser Thr Pro Gly Lys Leu Ile Asp Val Leu Ala Ile Val Gly Thr Thr
200 205 210
ttt ggt att gct gtg tca gta ggt ctt ggt gtg ctg caa atc aat gca 787
Phe Gly Ile Ala Val Ser Val Gly Leu Gly Val Leu Gln Ile Asn Ala
215 220 225
ggt atg aac aaa cta tgg agc acc ccg caa gta tcg tgg gtt cag ctt 835
Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val Ser Trp Val Gln Leu
230 235 240 245
ttg atc atc ttg atc atc acc gcg gtt gca tgt att tcc gtt gct tcc 883
Leu Ile Ile Leu Ile Ile Thr Ala Val Ala Cys Ile Ser Val Ala Ser
250 255 260
ggt ttg gat aag ggc att aag tta ctg tcc aac att aat att gca atg 931
Gly Leu Asp Lys Gly Ile Lys Leu Leu Ser Asn Ile Asn Ile Ala Met
265 270 275
gcc gtt gcg ttg atg ttc ttc atc ttg ttc act ggt cca acc ctc aca 979
Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr Gly Pro Thr Leu Thr
280 285 290
ttg ctg cgc ttt ctc gta gaa tcc ttc gga atc tat gca tcc tgg atg 1027
Leu Leu Arg Phe Leu Val Glu Ser Phe Gly Ile Tyr Ala Ser Trp Met
295 300 305
cct aat ctg atg ttt tgg act gac tct ttc caa gat aac cca ggc tgg 1075
Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln Asp Asn Pro Gly Trp
310 315 320 325
cag ggc aaa tgg acg gtg ttc tat tgg gca tgg act att tgt tgg tcg 1123
Gln Gly Lys Trp Thr Val Phe Tyr Trp Ala Trp Thr Ile Cys Trp Ser
330 335 340
cca tat gtc ggc atg ttc gtg gcg cgt att tcg cgt gga cgt acc gtc 1171
Pro Tyr Val Gly Met Phe Val Ala Arg Ile Ser Arg Gly Arg Thr Val
345 350 355
cgt gaa ttt atc ggt ggg gtt cta gct ctg cca gcg atc ttt ggc gta 1219
Arg Glu Phe Ile Gly Gly Val Leu Ala Leu Pro Ala Ile Phe Gly Val
360 365 370
gtt tgg ttc tct atc ttt ggt cgt gca ggc atc gaa gtg gaa ctg agt 1267
Val Trp Phe Ser Ile Phe Gly Arg Ala Gly Ile Glu Val Glu Leu Ser
375 380 385
aac cca ggt ttc ttg acc cag cca act gtt gtt gaa ggt gac gtg cca 1315
Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val Glu Gly Asp Val Pro
390 395 400 405
gca gcg ctt ttt aat gtg ctg caa gag tat ccg ctg act gga att gtc 1363
Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro Leu Thr Gly Ile Val
410 415 420
tcc gcg ttt gca ctt gta att att gtg att ttc ttt atc acc tcc atc 1411
Ser Ala Phe Ala Leu Val Ile Ile Val Ile Phe Phe Ile Thr Ser Ile
425 430 435
gat tcc gca gcg cta gtt aac gat atg ttc gct acc ggt gca gaa aat 1459
Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala Thr Gly Ala Glu Asn
440 445 450
caa aca ccg act agt tac cgc gtg atg tgg gcc tgc acc att ggg gcg 1507
Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Ala Cys Thr Ile Gly Ala
455 460 465
gtc gca ggt tcc ttg ctg atc att tcc cca tcc tct ggt att gcc acg 1555
Val Ala Gly Ser Leu Leu Ile Ile Ser Pro Ser Ser Gly Ile Ala Thr
470 475 480 485
ctg caa gaa gtg gtt atc atc gtg gct ttc cca ttc ttc ctc gtg caa 1603
Leu Gln Glu Val Val Ile Ile Val Ala Phe Pro Phe Phe Leu Val Gln
490 495 500
ttt gtc atg atg ttt tct ttg ctt aaa ggc atg agt gaa gat gct gct 1651
Phe Val Met Met Phe Ser Leu Leu Lys Gly Met Ser Glu Asp Ala Ala
505 510 515
gcg gtt cgt cgt gtg cag act cgt cag tgg gaa aag act gat aca cca 1699
Ala Val Arg Arg Val Gln Thr Arg Gln Trp Glu Lys Thr Asp Thr Pro
520 525 530
gaa aaa ctt gaa gag cat tcg tcc caa cca gcc ccg ggc tat gat gac 1747
Glu Lys Leu Glu Glu His Ser Ser Gln Pro Ala Pro Gly Tyr Asp Asp
535 540 545
gag ggc aac ccc ttg cca atg cct gcc ctc gaa cat gat gag gac ggt 1795
Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu His Asp Glu Asp Gly
550 555 560 565
aac att gtt atc cca ggc aac gta gtc att gaa ggt gat ctt ggg gta 1843
Asn Ile Val Ile Pro Gly Asn Val Val Ile Glu Gly Asp Leu Gly Val
570 575 580
gtt ggt gat gtg gtc gac gat cct gag gaa gcc caa gag atg ggg tct 1891
Val Gly Asp Val Val Asp Asp Pro Glu Glu Ala Gln Glu Met Gly Ser
585 590 595
cgt ttt aag atc gtc gag caa act cgg ccc cag tcc agg gac gaa tac 1939
Arg Phe Lys Ile Val Glu Gln Thr Arg Pro Gln Ser Arg Asp Glu Tyr
600 605 610
gat att taaacgattg cttttcgacg cac 1968
Asp Ile
615
<210> 534
<211> 615
<212> PRT
<213> Corynebacterium glutamicum
<400> 534
Met Ser Ser Asn Ile Ala Ile Thr Thr Glu Pro Glu Gly Lys Asn Lys
1 5 10 15
Lys Gly Leu Lys Ser Asp Pro Phe Ile Phe Ser Ile Ser Val Gly Phe
20 25 30
Ile Val Val Phe Val Ile Ala Thr Ile Ala Leu Gly Glu Lys Ala Arg
35 40 45
Thr Thr Phe Ser Ala Ile Ala Gly Trp Leu Leu Glu Asn Leu Gly Trp
50 55 60
Met Tyr Ile Gly Gly Val Ser Leu Val Phe Ile Phe Leu Met Gly Ile
65 70 75 80
Phe Ala Ser Arg Tyr Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp
85 90 95
Pro Glu His Thr Leu Ile Val Trp Phe Cys Met Leu Phe Ala Gly Gly
100 105 110
Val Gly Ala Val Leu Met Phe Trp Gly Val Ala Glu Pro Ile Asn His
115 120 125
Ala Phe Asn Val Pro Met Ala Asn Glu Glu Ser Met Ser Glu Ala Ala
130 135 140
Ile Val Gln Ala Phe Ala Tyr Thr Phe Tyr His Phe Gly Ile His Met
145 150 155 160
Trp Val Ile Met Ala Leu Pro Gly Leu Ser Leu Gly Tyr Phe Ile Tyr
165 170 175
Lys Arg Lys Leu Pro Pro Arg Leu Ser Ser Val Phe Ser Pro Ile Leu
180 185 190
Gly Lys His Ile Tyr Ser Thr Pro Gly Lys Leu Ile Asp Val Leu Ala
195 200 205
Ile Val Gly Thr Thr Phe Gly Ile Ala Val Ser Val Gly Leu Gly Val
210 215 220
Leu Gln Ile Asn Ala Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val
225 230 235 240
Ser Trp Val Gln Leu Leu Ile Ile Leu Ile Ile Thr Ala Val Ala Cys
245 250 255
Ile Ser Val Ala Ser Gly Leu Asp Lys Gly Ile Lys Leu Leu Ser Asn
260 265 270
Ile Asn Ile Ala Met Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr
275 280 285
Gly Pro Thr Leu Thr Leu Leu Arg Phe Leu Val Glu Ser Phe Gly Ile
290 295 300
Tyr Ala Ser Trp Met Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln
305 310 315 320
Asp Asn Pro Gly Trp Gln Gly Lys Trp Thr Val Phe Tyr Trp Ala Trp
325 330 335
Thr Ile Cys Trp Ser Pro Tyr Val Gly Met Phe Val Ala Arg Ile Ser
340 345 350
Arg Gly Arg Thr Val Arg Glu Phe Ile Gly Gly Val Leu Ala Leu Pro
355 360 365
Ala Ile Phe Gly Val Val Trp Phe Ser Ile Phe Gly Arg Ala Gly Ile
370 375 380
Glu Val Glu Leu Ser Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val
385 390 395 400
Glu Gly Asp Val Pro Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro
405 410 415
Leu Thr Gly Ile Val Ser Ala Phe Ala Leu Val Ile Ile Val Ile Phe
420 425 430
Phe Ile Thr Ser Ile Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala
435 440 445
Thr Gly Ala Glu Asn Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Ala
450 455 460
Cys Thr Ile Gly Ala Val Ala Gly Ser Leu Leu Ile Ile Ser Pro Ser
465 470 475 480
Ser Gly Ile Ala Thr Leu Gln Glu Val Val Ile Ile Val Ala Phe Pro
485 490 495
Phe Phe Leu Val Gln Phe Val Met Met Phe Ser Leu Leu Lys Gly Met
500 505 510
Ser Glu Asp Ala Ala Ala Val Arg Arg Val Gln Thr Arg Gln Trp Glu
515 520 525
Lys Thr Asp Thr Pro Glu Lys Leu Glu Glu His Ser Ser Gln Pro Ala
530 535 540
Pro Gly Tyr Asp Asp Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu
545 550 555 560
His Asp Glu Asp Gly Asn Ile Val Ile Pro Gly Asn Val Val Ile Glu
565 570 575
Gly Asp Leu Gly Val Val Gly Asp Val Val Asp Asp Pro Glu Glu Ala
580 585 590
Gln Glu Met Gly Ser Arg Phe Lys Ile Val Glu Gln Thr Arg Pro Gln
595 600 605
Ser Arg Asp Glu Tyr Asp Ile
610 615
<210> 535
<211> 1968
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1945)
<223> FRXA00298
<400> 535
tttagacaag ttctggttaa aattcttcat gaaggtgaga atctgggaat ttctcggtac 60
tctttcagat tcgtagttat ccactgattg gaagaatgag atg agc tca aat ata 115
Met Ser Ser Asn Ile
1 5
gct atc acg acc gag cct gaa ggg aaa aat aaa aag ggt ctc aaa tca 163
Ala Ile Thr Thr Glu Pro Glu Gly Lys Asn Lys Lys Gly Leu Lys Ser
10 15 20
gac ccg ttc att ttt tcc att tct gtc ggt ttt atc gtg gtg ttt gtc 211
Asp Pro Phe Ile Phe Ser Ile Ser Val Gly Phe Ile Val Val Phe Val
25 30 35
atc gcc aca att gcg cta ggc gag aaa gct cga aca acc ttt tcc gcg 259
Ile Ala Thr Ile Ala Leu Gly Glu Lys Ala Arg Thr Thr Phe Ser Ala
40 45 50
att gcc ggc tgg ctc tta gaa aat tta ggg tgg atg tat atc ggg ggt 307
Ile Ala Gly Trp Leu Leu Glu Asn Leu Gly Trp Met Tyr Ile Gly Gly
55 60 65
gtc tcc ttg gtt ttc att ttc ctc atg ggt atc ttt gcg tcc cgg tat 355
Val Ser Leu Val Phe Ile Phe Leu Met Gly Ile Phe Ala Ser Arg Tyr
70 75 80 85
ggc cgg gta aaa ctt ggt gat gac gat gat gac ccc gag cac acc cta 403
Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp Pro Glu His Thr Leu
90 95 100
atc gtg tgg ttc tgt atg ctt ttt gct ggc ggt gtc ggt gca gtc tta 451
Ile Val Trp Phe Cys Met Leu Phe Ala Gly Gly Val Gly Ala Val Leu
105 110 115
atg ttt tgg ggt gtt gcc gaa ccg att aac cac gcg ttc aac gtg cca 499
Met Phe Trp Gly Val Ala Glu Pro Ile Asn His Ala Phe Asn Val Pro
120 125 130
atg gct aat gaa gaa tcc atg agt gaa gcc gca att gtg cag gct ttt 547
Met Ala Asn Glu Glu Ser Met Ser Glu Ala Ala Ile Val Gln Ala Phe
135 140 145
gct tat act ttc tat cac ttc ggt att cac atg tgg gta atc atg gca 595
Ala Tyr Thr Phe Tyr His Phe Gly Ile His Met Trp Val Ile Met Ala
150 155 160 165
ctc cca gga tta tca ttg gga tac ttt att tac aaa cgt aag cta cct 643
Leu Pro Gly Leu Ser Leu Gly Tyr Phe Ile Tyr Lys Arg Lys Leu Pro
170 175 180
ccc cgt cta tcc tct gtg ttt tct ccg atc ttg ggt aag cac att tat 691
Pro Arg Leu Ser Ser Val Phe Ser Pro Ile Leu Gly Lys His Ile Tyr
185 190 195
tcc aca ccc ggc aag ctc atc gat gta ctg gcc atc gta ggc acc acg 739
Ser Thr Pro Gly Lys Leu Ile Asp Val Leu Ala Ile Val Gly Thr Thr
200 205 210
ttt ggt att gct gtg tca gta ggt ctt ggt gtg ctg caa atc aat gca 787
Phe Gly Ile Ala Val Ser Val Gly Leu Gly Val Leu Gln Ile Asn Ala
215 220 225
ggt atg aac aaa cta tgg agc acc ccg caa gta tcg tgg gtt cag ctt 835
Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val Ser Trp Val Gln Leu
230 235 240 245
ttg atc atc ttg atc atc acc gcg gtt gca tgt att tcc gtt gct tcc 883
Leu Ile Ile Leu Ile Ile Thr Ala Val Ala Cys Ile Ser Val Ala Ser
250 255 260
ggt ttg gat aag ggc att aag tta ctg tcc aac att aat att gca atg 931
Gly Leu Asp Lys Gly Ile Lys Leu Leu Ser Asn Ile Asn Ile Ala Met
265 270 275
gcc gtt gcg ttg atg ttc ttc atc ttg ttc act ggt cca acc ctc aca 979
Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr Gly Pro Thr Leu Thr
280 285 290
ttg ctg cgc ttt ctc gta gaa tcc ttc gga atc tat gca tcc tgg atg 1027
Leu Leu Arg Phe Leu Val Glu Ser Phe Gly Ile Tyr Ala Ser Trp Met
295 300 305
cct aat ctg atg ttt tgg act gac tct ttc caa gat aac cca ggc tgg 1075
Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln Asp Asn Pro Gly Trp
310 315 320 325
cag ggc aaa tgg acg gtg ttc tat tgg gca tgg act att tgt tgg tcg 1123
Gln Gly Lys Trp Thr Val Phe Tyr Trp Ala Trp Thr Ile Cys Trp Ser
330 335 340
cca tat gtc ggc atg ttc gtg gcg cgt att tcg cgt gga cgt acc gtc 1171
Pro Tyr Val Gly Met Phe Val Ala Arg Ile Ser Arg Gly Arg Thr Val
345 350 355
cgt gaa ttt atc ggt ggg gtt cta gct ctg cca gcg atc ttt ggc gta 1219
Arg Glu Phe Ile Gly Gly Val Leu Ala Leu Pro Ala Ile Phe Gly Val
360 365 370
gtt tgg ttc tct atc ttt ggt cgt gca ggc atc gaa gtg gaa ctg agt 1267
Val Trp Phe Ser Ile Phe Gly Arg Ala Gly Ile Glu Val Glu Leu Ser
375 380 385
aac cca ggt ttc ttg acc cag cca act gtt gtt gaa ggt gac gtg cca 1315
Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val Glu Gly Asp Val Pro
390 395 400 405
gca gcg ctt ttt aat gtg ctg caa gag tat ccg ctg act gga att gtc 1363
Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro Leu Thr Gly Ile Val
410 415 420
tcc gcg ttt gca ctt gta att att gtg att ttc ttt atc acc tcc atc 1411
Ser Ala Phe Ala Leu Val Ile Ile Val Ile Phe Phe Ile Thr Ser Ile
425 430 435
gat tcc gca gcg cta gtt aac gat atg ttc gct acc ggt gca gaa aat 1459
Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala Thr Gly Ala Glu Asn
440 445 450
caa aca ccg act agt tac cgc gtg atg tgg gcc tgc acc att ggg gcg 1507
Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Ala Cys Thr Ile Gly Ala
455 460 465
gtc gca ggt tcc ttg ctg atc att tcc cca tcc tct ggt att gcc acg 1555
Val Ala Gly Ser Leu Leu Ile Ile Ser Pro Ser Ser Gly Ile Ala Thr
470 475 480 485
ctg caa gaa gtg gtt atc atc gtg gct ttc cca ttc ttc ctc gtg caa 1603
Leu Gln Glu Val Val Ile Ile Val Ala Phe Pro Phe Phe Leu Val Gln
490 495 500
ttt gtc atg atg ttt tct ttg ctt aaa ggc atg agt gaa gat gct gct 1651
Phe Val Met Met Phe Ser Leu Leu Lys Gly Met Ser Glu Asp Ala Ala
505 510 515
gcg gtt cgt cgt gtg cag act cgt cag tgg gaa aag act gat aca cca 1699
Ala Val Arg Arg Val Gln Thr Arg Gln Trp Glu Lys Thr Asp Thr Pro
520 525 530
gaa aaa ctt gaa gag cat tcg tcc caa cca gcc ccg ggc tat gat gac 1747
Glu Lys Leu Glu Glu His Ser Ser Gln Pro Ala Pro Gly Tyr Asp Asp
535 540 545
gag ggc aac ccc ttg cca atg cct gcc ctc gaa cat gat gag gac ggt 1795
Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu His Asp Glu Asp Gly
550 555 560 565
aac att gtt atc cca ggc aac gta gtc att gaa ggt gat ctt ggg gta 1843
Asn Ile Val Ile Pro Gly Asn Val Val Ile Glu Gly Asp Leu Gly Val
570 575 580
gtt ggt gat gtg gtc gac gat cct gag gaa gcc caa gag atg ggg tct 1891
Val Gly Asp Val Val Asp Asp Pro Glu Glu Ala Gln Glu Met Gly Ser
585 590 595
cgt ttt aag atc gtc gag caa act cgg ccc cag tcc agg gac gaa tac 1939
Arg Phe Lys Ile Val Glu Gln Thr Arg Pro Gln Ser Arg Asp Glu Tyr
600 605 610
gat att taaacgattg cttttcgacg cac 1968
Asp Ile
615
<210> 536
<211> 615
<212> PRT
<213> Corynebacterium glutamicum
<400> 536
Met Ser Ser Asn Ile Ala Ile Thr Thr Glu Pro Glu Gly Lys Asn Lys
1 5 10 15
Lys Gly Leu Lys Ser Asp Pro Phe Ile Phe Ser Ile Ser Val Gly Phe
20 25 30
Ile Val Val Phe Val Ile Ala Thr Ile Ala Leu Gly Glu Lys Ala Arg
35 40 45
Thr Thr Phe Ser Ala Ile Ala Gly Trp Leu Leu Glu Asn Leu Gly Trp
50 55 60
Met Tyr Ile Gly Gly Val Ser Leu Val Phe Ile Phe Leu Met Gly Ile
65 70 75 80
Phe Ala Ser Arg Tyr Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp
85 90 95
Pro Glu His Thr Leu Ile Val Trp Phe Cys Met Leu Phe Ala Gly Gly
100 105 110
Val Gly Ala Val Leu Met Phe Trp Gly Val Ala Glu Pro Ile Asn His
115 120 125
Ala Phe Asn Val Pro Met Ala Asn Glu Glu Ser Met Ser Glu Ala Ala
130 135 140
Ile Val Gln Ala Phe Ala Tyr Thr Phe Tyr His Phe Gly Ile His Met
145 150 155 160
Trp Val Ile Met Ala Leu Pro Gly Leu Ser Leu Gly Tyr Phe Ile Tyr
165 170 175
Lys Arg Lys Leu Pro Pro Arg Leu Ser Ser Val Phe Ser Pro Ile Leu
180 185 190
Gly Lys His Ile Tyr Ser Thr Pro Gly Lys Leu Ile Asp Val Leu Ala
195 200 205
Ile Val Gly Thr Thr Phe Gly Ile Ala Val Ser Val Gly Leu Gly Val
210 215 220
Leu Gln Ile Asn Ala Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val
225 230 235 240
Ser Trp Val Gln Leu Leu Ile Ile Leu Ile Ile Thr Ala Val Ala Cys
245 250 255
Ile Ser Val Ala Ser Gly Leu Asp Lys Gly Ile Lys Leu Leu Ser Asn
260 265 270
Ile Asn Ile Ala Met Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr
275 280 285
Gly Pro Thr Leu Thr Leu Leu Arg Phe Leu Val Glu Ser Phe Gly Ile
290 295 300
Tyr Ala Ser Trp Met Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln
305 310 315 320
Asp Asn Pro Gly Trp Gln Gly Lys Trp Thr Val Phe Tyr Trp Ala Trp
325 330 335
Thr Ile Cys Trp Ser Pro Tyr Val Gly Met Phe Val Ala Arg Ile Ser
340 345 350
Arg Gly Arg Thr Val Arg Glu Phe Ile Gly Gly Val Leu Ala Leu Pro
355 360 365
Ala Ile Phe Gly Val Val Trp Phe Ser Ile Phe Gly Arg Ala Gly Ile
370 375 380
Glu Val Glu Leu Ser Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val
385 390 395 400
Glu Gly Asp Val Pro Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro
405 410 415
Leu Thr Gly Ile Val Ser Ala Phe Ala Leu Val Ile Ile Val Ile Phe
420 425 430
Phe Ile Thr Ser Ile Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala
435 440 445
Thr Gly Ala Glu Asn Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Ala
450 455 460
Cys Thr Ile Gly Ala Val Ala Gly Ser Leu Leu Ile Ile Ser Pro Ser
465 470 475 480
Ser Gly Ile Ala Thr Leu Gln Glu Val Val Ile Ile Val Ala Phe Pro
485 490 495
Phe Phe Leu Val Gln Phe Val Met Met Phe Ser Leu Leu Lys Gly Met
500 505 510
Ser Glu Asp Ala Ala Ala Val Arg Arg Val Gln Thr Arg Gln Trp Glu
515 520 525
Lys Thr Asp Thr Pro Glu Lys Leu Glu Glu His Ser Ser Gln Pro Ala
530 535 540
Pro Gly Tyr Asp Asp Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu
545 550 555 560
His Asp Glu Asp Gly Asn Ile Val Ile Pro Gly Asn Val Val Ile Glu
565 570 575
Gly Asp Leu Gly Val Val Gly Asp Val Val Asp Asp Pro Glu Glu Ala
580 585 590
Gln Glu Met Gly Ser Arg Phe Lys Ile Val Glu Gln Thr Arg Pro Gln
595 600 605
Ser Arg Asp Glu Tyr Asp Ile
610 615
<210> 537
<211> 576
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(553)
<223> RXA00596
<400> 537
ccgccaccga cggcctcttg aacaccgatg cataccaaca ggctgtgctc ggtgaaaatg 60
ccatcggagt gccaagccct agctaccagg gaggaaacta atg ctt aac gcc ctg 115
Met Leu Asn Ala Leu
1 5
aaa ttc atc cca tgg ctg atc ggc cag att ttc ctc tct ggc ttc agc 163
Lys Phe Ile Pro Trp Leu Ile Gly Gln Ile Phe Leu Ser Gly Phe Ser
10 15 20
gtg atc acc gct gcg gta aaa aag gac acc ggc ttc aac ccc gtt gtt 211
Val Ile Thr Ala Ala Val Lys Lys Asp Thr Gly Phe Asn Pro Val Val
25 30 35
atc cgc tac cca ctt cga gtg acc acg gac ttc cag atc gca gcc ctg 259
Ile Arg Tyr Pro Leu Arg Val Thr Thr Asp Phe Gln Ile Ala Ala Leu
40 45 50
tca acg tgc atc acc gcg act cct tcc acc ctg tcc ctt ggc cta cgc 307
Ser Thr Cys Ile Thr Ala Thr Pro Ser Thr Leu Ser Leu Gly Leu Arg
55 60 65
gaa ccc cgc aag ccc ggc gac ccc acc att ttg ctg atc caa gca gtg 355
Glu Pro Arg Lys Pro Gly Asp Pro Thr Ile Leu Leu Ile Gln Ala Val
70 75 80 85
ttt ggt tcc gat cca gta gaa gtt ttt gaa tcc atc gcc gat atg gaa 403
Phe Gly Ser Asp Pro Val Glu Val Phe Glu Ser Ile Ala Asp Met Glu
90 95 100
caa cgc ctc gtc cct tcg gtc gct tca att gac cac ggc gtc cca ggc 451
Gln Arg Leu Val Pro Ser Val Ala Ser Ile Asp His Gly Val Pro Gly
105 110 115
caa ggc cct tac aag gag atc cgc ccc agc gat gct gag tgg cca agt 499
Gln Gly Pro Tyr Lys Glu Ile Arg Pro Ser Asp Ala Glu Trp Pro Ser
120 125 130
cgc gag atc gct gac acc gcc caa aac acc gtc agc caa gac aag agg 547
Arg Glu Ile Ala Asp Thr Ala Gln Asn Thr Val Ser Gln Asp Lys Arg
135 140 145
gag ttt taaaacaaca tgactgcttt tgg 576
Glu Phe
150
<210> 538
<211> 151
<212> PRT
<213> Corynebacterium glutamicum
<400> 538
Met Leu Asn Ala Leu Lys Phe Ile Pro Trp Leu Ile Gly Gln Ile Phe
1 5 10 15
Leu Ser Gly Phe Ser Val Ile Thr Ala Ala Val Lys Lys Asp Thr Gly
20 25 30
Phe Asn Pro Val Val Ile Arg Tyr Pro Leu Arg Val Thr Thr Asp Phe
35 40 45
Gln Ile Ala Ala Leu Ser Thr Cys Ile Thr Ala Thr Pro Ser Thr Leu
50 55 60
Ser Leu Gly Leu Arg Glu Pro Arg Lys Pro Gly Asp Pro Thr Ile Leu
65 70 75 80
Leu Ile Gln Ala Val Phe Gly Ser Asp Pro Val Glu Val Phe Glu Ser
85 90 95
Ile Ala Asp Met Glu Gln Arg Leu Val Pro Ser Val Ala Ser Ile Asp
100 105 110
His Gly Val Pro Gly Gln Gly Pro Tyr Lys Glu Ile Arg Pro Ser Asp
115 120 125
Ala Glu Trp Pro Ser Arg Glu Ile Ala Asp Thr Ala Gln Asn Thr Val
130 135 140
Ser Gln Asp Lys Arg Glu Phe
145 150
<210> 539
<211> 750
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(727)
<223> RXA02364
<400> 539
gcgaaagtat ctaaggtcgt ttgattggtt tactaccccc gaagtggggg ttattggcag 60
catcgagcac caaatgagcg tgatccggga tcaggatctg atg gag cca ctg ttc 115
Met Glu Pro Leu Phe
1 5
caa agt ctt gcg gaa tcg gac aat att tct gtc att ggt gga ttt acc 163
Gln Ser Leu Ala Glu Ser Asp Asn Ile Ser Val Ile Gly Gly Phe Thr
10 15 20
caa ggc acc cga aat ctg tac acc act gat gcg ccg gtg aaa aga ccc 211
Gln Gly Thr Arg Asn Leu Tyr Thr Thr Asp Ala Pro Val Lys Arg Pro
25 30 35
gct gac ctg gct gga aag aag att cgc gtc cag gaa tcc gcc atg cac 259
Ala Asp Leu Ala Gly Lys Lys Ile Arg Val Gln Glu Ser Ala Met His
40 45 50
atc cgc atg att gaa ctc atg ggt ggc tcg gca acc ccg ttg act tac 307
Ile Arg Met Ile Glu Leu Met Gly Gly Ser Ala Thr Pro Leu Thr Tyr
55 60 65
ggc gag gta tat acc gcg atg cag tct ggt gtg ctg gat ggc gcg gaa 355
Gly Glu Val Tyr Thr Ala Met Gln Ser Gly Val Leu Asp Gly Ala Glu
70 75 80 85
aat aac gag atc agt tac gtt acc caa aac cac ttc gag gtt gct cgc 403
Asn Asn Glu Ile Ser Tyr Val Thr Gln Asn His Phe Glu Val Ala Arg
90 95 100
tac aac agc aac acc aat cac ctt gtc ggt ttg gat tac atg gtc atg 451
Tyr Asn Ser Asn Thr Asn His Leu Val Gly Leu Asp Tyr Met Val Met
105 110 115
cga cac gat ctg ctt gac gcc atg agc gag cca gac cgt gaa ttg ttc 499
Arg His Asp Leu Leu Asp Ala Met Ser Glu Pro Asp Arg Glu Leu Phe
120 125 130
ctg gaa gaa tgg gac gcc gcg atg act gag cac acg gat ctg tgg aac 547
Leu Glu Glu Trp Asp Ala Ala Met Thr Glu His Thr Asp Leu Trp Asn
135 140 145
aca gaa act gat gcc gtt att gaa aag gcg aaa gct ggg gga gcg gag 595
Thr Glu Thr Asp Ala Val Ile Glu Lys Ala Lys Ala Gly Gly Ala Glu
150 155 160 165
ttc gtt gag gtg gat gcg caa gca ttt acc gat gca ctg gct ccc atc 643
Phe Val Glu Val Asp Ala Gln Ala Phe Thr Asp Ala Leu Ala Pro Ile
170 175 180
aaa gac gaa ttc ttg acc tca gaa ttc cag cgt gaa ctc tac gaa gca 691
Lys Asp Glu Phe Leu Thr Ser Glu Phe Gln Arg Glu Leu Tyr Glu Ala
185 190 195
gtg cgc gcc gct gat act tca gga ggt gcg gca tca tgatgaattt 737
Val Arg Ala Ala Asp Thr Ser Gly Gly Ala Ala Ser
200 205
taagtccatc gtg 750
<210> 540
<211> 209
<212> PRT
<213> Corynebacterium glutamicum
<400> 540
Met Glu Pro Leu Phe Gln Ser Leu Ala Glu Ser Asp Asn Ile Ser Val
1 5 10 15
Ile Gly Gly Phe Thr Gln Gly Thr Arg Asn Leu Tyr Thr Thr Asp Ala
20 25 30
Pro Val Lys Arg Pro Ala Asp Leu Ala Gly Lys Lys Ile Arg Val Gln
35 40 45
Glu Ser Ala Met His Ile Arg Met Ile Glu Leu Met Gly Gly Ser Ala
50 55 60
Thr Pro Leu Thr Tyr Gly Glu Val Tyr Thr Ala Met Gln Ser Gly Val
65 70 75 80
Leu Asp Gly Ala Glu Asn Asn Glu Ile Ser Tyr Val Thr Gln Asn His
85 90 95
Phe Glu Val Ala Arg Tyr Asn Ser Asn Thr Asn His Leu Val Gly Leu
100 105 110
Asp Tyr Met Val Met Arg His Asp Leu Leu Asp Ala Met Ser Glu Pro
115 120 125
Asp Arg Glu Leu Phe Leu Glu Glu Trp Asp Ala Ala Met Thr Glu His
130 135 140
Thr Asp Leu Trp Asn Thr Glu Thr Asp Ala Val Ile Glu Lys Ala Lys
145 150 155 160
Ala Gly Gly Ala Glu Phe Val Glu Val Asp Ala Gln Ala Phe Thr Asp
165 170 175
Ala Leu Ala Pro Ile Lys Asp Glu Phe Leu Thr Ser Glu Phe Gln Arg
180 185 190
Glu Leu Tyr Glu Ala Val Arg Ala Ala Asp Thr Ser Gly Gly Ala Ala
195 200 205
Ser
<210> 541
<211> 888
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(865)
<223> RXN01411
<400> 541
cttatcgacg tccccatccc cctcgccaat gcttcggcga ggggttctat ttattgtgtg 60
tgctagcctt ttcgcaatcg ttcagcccgc cccgacgtca atg ttg gga gtg ggc 115
Met Leu Gly Val Gly
1 5
tgg cgc att cca ttc ctg atg gcc gtg cca cta ggg ctt atc ggc tgg 163
Trp Arg Ile Pro Phe Leu Met Ala Val Pro Leu Gly Leu Ile Gly Trp
10 15 20
tgg atc cgc acc ggt gcc cag gaa aat gta cgc ccc gca tcc gaa cgc 211
Trp Ile Arg Thr Gly Ala Gln Glu Asn Val Arg Pro Ala Ser Glu Arg
25 30 35
ccc gaa gct cct att aag cag gca ttg cgt act gag tgg aag atg atg 259
Pro Glu Ala Pro Ile Lys Gln Ala Leu Arg Thr Glu Trp Lys Met Met
40 45 50
ttg cgg gta ggt ggc ttt atc tct tgc acc ggt ctg agc ttc tac att 307
Leu Arg Val Gly Gly Phe Ile Ser Cys Thr Gly Leu Ser Phe Tyr Ile
55 60 65
ttc acc acg tac atg acc act ttc ctg cgc agc acc gtc gga ctg gag 355
Phe Thr Thr Tyr Met Thr Thr Phe Leu Arg Ser Thr Val Gly Leu Glu
70 75 80 85
ggc acg tta gtg ctg gct gga aac atc atc gct ctc agc atg gca gca 403
Gly Thr Leu Val Leu Ala Gly Asn Ile Ile Ala Leu Ser Met Ala Ala
90 95 100
att gtg gcc cca ttt gtt ggc cgc gca att gat aaa ttc ccc cgc cgg 451
Ile Val Ala Pro Phe Val Gly Arg Ala Ile Asp Lys Phe Pro Arg Arg
105 110 115
aac atc atg gct ttc gct acc tta agc aca gta att atg gcg atc ccg 499
Asn Ile Met Ala Phe Ala Thr Leu Ser Thr Val Ile Met Ala Ile Pro
120 125 130
gcc tac atc att gca ggt caa ggt act ttg act gct tct ttg att gcg 547
Ala Tyr Ile Ile Ala Gly Gln Gly Thr Leu Thr Ala Ser Leu Ile Ala
135 140 145
cag gta atg ctt gga atc ggc gcg gtt acc gct aac tgc gtt acc tca 595
Gln Val Met Leu Gly Ile Gly Ala Val Thr Ala Asn Cys Val Thr Ser
150 155 160 165
gta atg atg gcc gag gtc ttc caa gag gtc acc cgc ggt act tcc gcc 643
Val Met Met Ala Glu Val Phe Gln Glu Val Thr Arg Gly Thr Ser Ala
170 175 180
ggc att acc tac aac gtc act tac gca atc ttc ggc ggc tcg gct cca 691
Gly Ile Thr Tyr Asn Val Thr Tyr Ala Ile Phe Gly Gly Ser Ala Pro
185 190 195
ttt atc tcc acc gca ttg gtc tcc tgg acc ggc agc ccg ctg gcc cct 739
Phe Ile Ser Thr Ala Leu Val Ser Trp Thr Gly Ser Pro Leu Ala Pro
200 205 210
gcg gta tac atg atc atc att gcg ctc ttc gcc ttc acc gcg tcc cgc 787
Ala Val Tyr Met Ile Ile Ile Ala Leu Phe Ala Phe Thr Ala Ser Arg
215 220 225
ttc att cct gaa acc tcc cca gtt ttt gtc acc gca acc ccg gcc att 835
Phe Ile Pro Glu Thr Ser Pro Val Phe Val Thr Ala Thr Pro Ala Ile
230 235 240 245
aag gca cca aag gtg ctg gtc aac ccg ggt taaaccacgc ttttcgacga 885
Lys Ala Pro Lys Val Leu Val Asn Pro Gly
250 255
aaa 888
<210> 542
<211> 255
<212> PRT
<213> Corynebacterium glutamicum
<400> 542
Met Leu Gly Val Gly Trp Arg Ile Pro Phe Leu Met Ala Val Pro Leu
1 5 10 15
Gly Leu Ile Gly Trp Trp Ile Arg Thr Gly Ala Gln Glu Asn Val Arg
20 25 30
Pro Ala Ser Glu Arg Pro Glu Ala Pro Ile Lys Gln Ala Leu Arg Thr
35 40 45
Glu Trp Lys Met Met Leu Arg Val Gly Gly Phe Ile Ser Cys Thr Gly
50 55 60
Leu Ser Phe Tyr Ile Phe Thr Thr Tyr Met Thr Thr Phe Leu Arg Ser
65 70 75 80
Thr Val Gly Leu Glu Gly Thr Leu Val Leu Ala Gly Asn Ile Ile Ala
85 90 95
Leu Ser Met Ala Ala Ile Val Ala Pro Phe Val Gly Arg Ala Ile Asp
100 105 110
Lys Phe Pro Arg Arg Asn Ile Met Ala Phe Ala Thr Leu Ser Thr Val
115 120 125
Ile Met Ala Ile Pro Ala Tyr Ile Ile Ala Gly Gln Gly Thr Leu Thr
130 135 140
Ala Ser Leu Ile Ala Gln Val Met Leu Gly Ile Gly Ala Val Thr Ala
145 150 155 160
Asn Cys Val Thr Ser Val Met Met Ala Glu Val Phe Gln Glu Val Thr
165 170 175
Arg Gly Thr Ser Ala Gly Ile Thr Tyr Asn Val Thr Tyr Ala Ile Phe
180 185 190
Gly Gly Ser Ala Pro Phe Ile Ser Thr Ala Leu Val Ser Trp Thr Gly
195 200 205
Ser Pro Leu Ala Pro Ala Val Tyr Met Ile Ile Ile Ala Leu Phe Ala
210 215 220
Phe Thr Ala Ser Arg Phe Ile Pro Glu Thr Ser Pro Val Phe Val Thr
225 230 235 240
Ala Thr Pro Ala Ile Lys Ala Pro Lys Val Leu Val Asn Pro Gly
245 250 255
<210> 543
<211> 1058
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(1035)
<223> RXN00960
<400> 543
atg gct cgg cat tgt tgc agc aat cgc tac gcg tcc acc gtc ttc tcc 48
Met Ala Arg His Cys Cys Ser Asn Arg Tyr Ala Ser Thr Val Phe Ser
1 5 10 15
ggt ctg atc gcc tac gga gca tcc caa gcg ctc tac cca tgg ctg ctg 96
Gly Leu Ile Ala Tyr Gly Ala Ser Gln Ala Leu Tyr Pro Trp Leu Leu
20 25 30
aaa gac cac caa agc gtc acc gaa atc gac ctt gat gca ggt gcc ctc 144
Lys Asp His Gln Ser Val Thr Glu Ile Asp Leu Asp Ala Gly Ala Leu
35 40 45
cag ccc tac ttc aac atc gag atg cca cca cca ttt gaa gtg atg acc 192
Gln Pro Tyr Phe Asn Ile Glu Met Pro Pro Pro Phe Glu Val Met Thr
50 55 60
gca ctg ctg ctg gca ttc tgc ctc ggc ctg ggc atg gct gta att aaa 240
Ala Leu Leu Leu Ala Phe Cys Leu Gly Leu Gly Met Ala Val Ile Lys
65 70 75 80
tca gac acc ctg ttc aag gta acc cgc gaa ctc gag cgc gta gtc atg 288
Ser Asp Thr Leu Phe Lys Val Thr Arg Glu Leu Glu Arg Val Val Met
85 90 95
aag acc atc acc gcc ttt gtc atc cca ctg ctg cca ctc ttc atc ttc 336
Lys Thr Ile Thr Ala Phe Val Ile Pro Leu Leu Pro Leu Phe Ile Phe
100 105 110
ggc atc ttc ctc ggc atg ggc atg aac ggt ggc ctc ctg gag atc atg 384
Gly Ile Phe Leu Gly Met Gly Met Asn Gly Gly Leu Leu Glu Ile Met
115 120 125
tcc gcc ttt ggc aag gta ctg att ctc gcc gtc gtg gga acc ctg ctc 432
Ser Ala Phe Gly Lys Val Leu Ile Leu Ala Val Val Gly Thr Leu Leu
130 135 140
ttc cta gcc atc cag ttc att atc gct ggt gca gta tcc aag aag aac 480
Phe Leu Ala Ile Gln Phe Ile Ile Ala Gly Ala Val Ser Lys Lys Asn
145 150 155 160
cca tgg aaa ctg ttc aaa aac atg ctc cct gca tac ttc act gca ctg 528
Pro Trp Lys Leu Phe Lys Asn Met Leu Pro Ala Tyr Phe Thr Ala Leu
165 170 175
ggc act tcc tct tca gcg gca acc atc cca gtg acc tac cag cag acc 576
Gly Thr Ser Ser Ser Ala Ala Thr Ile Pro Val Thr Tyr Gln Gln Thr
180 185 190
ctg aaa aac gat gtt gat gtc aac gtc gca ggc ttt gtt gtc cca ctg 624
Leu Lys Asn Asp Val Asp Val Asn Val Ala Gly Phe Val Val Pro Leu
195 200 205
tgc gcc acc atc cac cta gct gga tcg atg atg aag atc ggc ctc ttc 672
Cys Ala Thr Ile His Leu Ala Gly Ser Met Met Lys Ile Gly Leu Phe
210 215 220
acc ttc gct gtt gtc ttc atg tac gac atg gaa gta ggc gtc ggc ctc 720
Thr Phe Ala Val Val Phe Met Tyr Asp Met Glu Val Gly Val Gly Leu
225 230 235 240
tcc atc gga ttc ctc ctc atg ctg ggc atc acc atg atc gcc gca cca 768
Ser Ile Gly Phe Leu Leu Met Leu Gly Ile Thr Met Ile Ala Ala Pro
245 250 255
ggc gtt ccc ggc gga gcc atc atg gca gca acc ggc atg ctg gcc tcc 816
Gly Val Pro Gly Gly Ala Ile Met Ala Ala Thr Gly Met Leu Ala Ser
260 265 270
atg ctc gga ttc aac acc gaa caa gtc gcc ctc atg atc gcc gct tac 864
Met Leu Gly Phe Asn Thr Glu Gln Val Ala Leu Met Ile Ala Ala Tyr
275 280 285
atc gcg att gac tcc ttc ggc acc gca gca aac gtc acc ggc gac ggc 912
Ile Ala Ile Asp Ser Phe Gly Thr Ala Ala Asn Val Thr Gly Asp Gly
290 295 300
gca atc gca gtc atc gtg aac aaa ttc gcc aag ggc cag ctg cac acc 960
Ala Ile Ala Val Ile Val Asn Lys Phe Ala Lys Gly Gln Leu His Thr
305 310 315 320
act tcc cca gat gaa atc gaa gaa gac gac cgc gtt gcc ttc gac atc 1008
Thr Ser Pro Asp Glu Ile Glu Glu Asp Asp Arg Val Ala Phe Asp Ile
325 330 335
act cca tcg gat gtg gaa cat cac aag tagaaacccg cattttctgt 1055
Thr Pro Ser Asp Val Glu His His Lys
340 345
agt 1058
<210> 544
<211> 345
<212> PRT
<213> Corynebacterium glutamicum
<400> 544
Met Ala Arg His Cys Cys Ser Asn Arg Tyr Ala Ser Thr Val Phe Ser
1 5 10 15
Gly Leu Ile Ala Tyr Gly Ala Ser Gln Ala Leu Tyr Pro Trp Leu Leu
20 25 30
Lys Asp His Gln Ser Val Thr Glu Ile Asp Leu Asp Ala Gly Ala Leu
35 40 45
Gln Pro Tyr Phe Asn Ile Glu Met Pro Pro Pro Phe Glu Val Met Thr
50 55 60
Ala Leu Leu Leu Ala Phe Cys Leu Gly Leu Gly Met Ala Val Ile Lys
65 70 75 80
Ser Asp Thr Leu Phe Lys Val Thr Arg Glu Leu Glu Arg Val Val Met
85 90 95
Lys Thr Ile Thr Ala Phe Val Ile Pro Leu Leu Pro Leu Phe Ile Phe
100 105 110
Gly Ile Phe Leu Gly Met Gly Met Asn Gly Gly Leu Leu Glu Ile Met
115 120 125
Ser Ala Phe Gly Lys Val Leu Ile Leu Ala Val Val Gly Thr Leu Leu
130 135 140
Phe Leu Ala Ile Gln Phe Ile Ile Ala Gly Ala Val Ser Lys Lys Asn
145 150 155 160
Pro Trp Lys Leu Phe Lys Asn Met Leu Pro Ala Tyr Phe Thr Ala Leu
165 170 175
Gly Thr Ser Ser Ser Ala Ala Thr Ile Pro Val Thr Tyr Gln Gln Thr
180 185 190
Leu Lys Asn Asp Val Asp Val Asn Val Ala Gly Phe Val Val Pro Leu
195 200 205
Cys Ala Thr Ile His Leu Ala Gly Ser Met Met Lys Ile Gly Leu Phe
210 215 220
Thr Phe Ala Val Val Phe Met Tyr Asp Met Glu Val Gly Val Gly Leu
225 230 235 240
Ser Ile Gly Phe Leu Leu Met Leu Gly Ile Thr Met Ile Ala Ala Pro
245 250 255
Gly Val Pro Gly Gly Ala Ile Met Ala Ala Thr Gly Met Leu Ala Ser
260 265 270
Met Leu Gly Phe Asn Thr Glu Gln Val Ala Leu Met Ile Ala Ala Tyr
275 280 285
Ile Ala Ile Asp Ser Phe Gly Thr Ala Ala Asn Val Thr Gly Asp Gly
290 295 300
Ala Ile Ala Val Ile Val Asn Lys Phe Ala Lys Gly Gln Leu His Thr
305 310 315 320
Thr Ser Pro Asp Glu Ile Glu Glu Asp Asp Arg Val Ala Phe Asp Ile
325 330 335
Thr Pro Ser Asp Val Glu His His Lys
340 345
<210> 545
<211> 1118
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(1095)
<223> RXN02447
<400> 545
aca gta gtt ccg gtg tac ctc gct gaa ctc gca cca cta gaa atc cgc 48
Thr Val Val Pro Val Tyr Leu Ala Glu Leu Ala Pro Leu Glu Ile Arg
1 5 10 15
ggc tcc ctg acc ggc cga aac gag ctt gct atc gtc acc ggc cag ctg 96
Gly Ser Leu Thr Gly Arg Asn Glu Leu Ala Ile Val Thr Gly Gln Leu
20 25 30
ctt gcc ttc gtg atc aac gcg ctt atc gcc gtc acc cta cac gga gtt 144
Leu Ala Phe Val Ile Asn Ala Leu Ile Ala Val Thr Leu His Gly Val
35 40 45
att gat gga atc tgg cgc atc atg ttc gcc gtc tgt gcc ctc cct gcc 192
Ile Asp Gly Ile Trp Arg Ile Met Phe Ala Val Cys Ala Leu Pro Ala
50 55 60
gtc gcc ctc ttc ctc ggc atg ctg cgg atg ccg gaa tca cca cgc tgg 240
Val Ala Leu Phe Leu Gly Met Leu Arg Met Pro Glu Ser Pro Arg Trp
65 70 75 80
ctg gtc aac cag ggg cgt tac gac gac gcc cgc cgc gtc atg gag acc 288
Leu Val Asn Gln Gly Arg Tyr Asp Asp Ala Arg Arg Val Met Glu Thr
85 90 95
gtc cgt acc cct gag cgt gcg aaa gcc gaa atg gat gaa atc atc gcg 336
Val Arg Thr Pro Glu Arg Ala Lys Ala Glu Met Asp Glu Ile Ile Ala
100 105 110
gtg cac tct gaa aac aat gcg gca ctt cct ggt gtt aag cag tct tcg 384
Val His Ser Glu Asn Asn Ala Ala Leu Pro Gly Val Lys Gln Ser Ser
115 120 125
ggc cag gct tca ggc cag gtt tct agc aag cac acc cac atg tcc atc 432
Gly Gln Ala Ser Gly Gln Val Ser Ser Lys His Thr His Met Ser Ile
130 135 140
ggc gaa gtc ctc agc aac aaa tgg ctg gtt cgt ctg ctc atc gcc ggc 480
Gly Glu Val Leu Ser Asn Lys Trp Leu Val Arg Leu Leu Ile Ala Gly
145 150 155 160
atc ggt gtt gca gtt gcc cag cag ctc acc ggc atc aac gcc atc atg 528
Ile Gly Val Ala Val Ala Gln Gln Leu Thr Gly Ile Asn Ala Ile Met
165 170 175
tac tac gga acc cgc gtc ctc gag gaa tcc ggc atg agc gca gaa atg 576
Tyr Tyr Gly Thr Arg Val Leu Glu Glu Ser Gly Met Ser Ala Glu Met
180 185 190
gct gtg gtt gcc aac att gct ttc ggt gcc gtt gcc gtc atc ggt gga 624
Ala Val Val Ala Asn Ile Ala Phe Gly Ala Val Ala Val Ile Gly Gly
195 200 205
ctg atc gca ctg cgc aac atg gac cgc ctg gat cgc cgc acc acc ttc 672
Leu Ile Ala Leu Arg Asn Met Asp Arg Leu Asp Arg Arg Thr Thr Phe
210 215 220
atc atc ggc ctg tca ctg acc acc acc ttc cac ctt ttg atc gca gct 720
Ile Ile Gly Leu Ser Leu Thr Thr Thr Phe His Leu Leu Ile Ala Ala
225 230 235 240
gcc ggc act ctc ctt cca gaa ggt aac tcc att cga cca ttc gcc atc 768
Ala Gly Thr Leu Leu Pro Glu Gly Asn Ser Ile Arg Pro Phe Ala Ile
245 250 255
atg atc ctt gtt gtt ggg ttc gtg ctc tcc atg cag act ttc ctc aac 816
Met Ile Leu Val Val Gly Phe Val Leu Ser Met Gln Thr Phe Leu Asn
260 265 270
gtt gca gtg tgg gtg tgg ctg gcg gaa atc ttc cca gtc cga atg aag 864
Val Ala Val Trp Val Trp Leu Ala Glu Ile Phe Pro Val Arg Met Lys
275 280 285
ggt atc ggc acc ggt att tcg gta ttc tgc ggt tgg ggc atc aat ggc 912
Gly Ile Gly Thr Gly Ile Ser Val Phe Cys Gly Trp Gly Ile Asn Gly
290 295 300
gtc cta gcg ttg ttc ttc cca gca ctg gtc tcc ggc gtg ggt atc acc 960
Val Leu Ala Leu Phe Phe Pro Ala Leu Val Ser Gly Val Gly Ile Thr
305 310 315 320
ttc tcc ttc ctt atc ttc gca gtc gtc gga gtc att gcc ctg gcg ttc 1008
Phe Ser Phe Leu Ile Phe Ala Val Val Gly Val Ile Ala Leu Ala Phe
325 330 335
gtc acc aag ttt gtt cct gaa acc cgt ggc cgc tca ctt gaa gaa ctc 1056
Val Thr Lys Phe Val Pro Glu Thr Arg Gly Arg Ser Leu Glu Glu Leu
340 345 350
gat cac gca gca ttc acc ggc cag atc ttc aag aag gct taaaccccct 1105
Asp His Ala Ala Phe Thr Gly Gln Ile Phe Lys Lys Ala
355 360 365
ccgatctctt tgg 1118
<210> 546
<211> 365
<212> PRT
<213> Corynebacterium glutamicum
<400> 546
Thr Val Val Pro Val Tyr Leu Ala Glu Leu Ala Pro Leu Glu Ile Arg
1 5 10 15
Gly Ser Leu Thr Gly Arg Asn Glu Leu Ala Ile Val Thr Gly Gln Leu
20 25 30
Leu Ala Phe Val Ile Asn Ala Leu Ile Ala Val Thr Leu His Gly Val
35 40 45
Ile Asp Gly Ile Trp Arg Ile Met Phe Ala Val Cys Ala Leu Pro Ala
50 55 60
Val Ala Leu Phe Leu Gly Met Leu Arg Met Pro Glu Ser Pro Arg Trp
65 70 75 80
Leu Val Asn Gln Gly Arg Tyr Asp Asp Ala Arg Arg Val Met Glu Thr
85 90 95
Val Arg Thr Pro Glu Arg Ala Lys Ala Glu Met Asp Glu Ile Ile Ala
100 105 110
Val His Ser Glu Asn Asn Ala Ala Leu Pro Gly Val Lys Gln Ser Ser
115 120 125
Gly Gln Ala Ser Gly Gln Val Ser Ser Lys His Thr His Met Ser Ile
130 135 140
Gly Glu Val Leu Ser Asn Lys Trp Leu Val Arg Leu Leu Ile Ala Gly
145 150 155 160
Ile Gly Val Ala Val Ala Gln Gln Leu Thr Gly Ile Asn Ala Ile Met
165 170 175
Tyr Tyr Gly Thr Arg Val Leu Glu Glu Ser Gly Met Ser Ala Glu Met
180 185 190
Ala Val Val Ala Asn Ile Ala Phe Gly Ala Val Ala Val Ile Gly Gly
195 200 205
Leu Ile Ala Leu Arg Asn Met Asp Arg Leu Asp Arg Arg Thr Thr Phe
210 215 220
Ile Ile Gly Leu Ser Leu Thr Thr Thr Phe His Leu Leu Ile Ala Ala
225 230 235 240
Ala Gly Thr Leu Leu Pro Glu Gly Asn Ser Ile Arg Pro Phe Ala Ile
245 250 255
Met Ile Leu Val Val Gly Phe Val Leu Ser Met Gln Thr Phe Leu Asn
260 265 270
Val Ala Val Trp Val Trp Leu Ala Glu Ile Phe Pro Val Arg Met Lys
275 280 285
Gly Ile Gly Thr Gly Ile Ser Val Phe Cys Gly Trp Gly Ile Asn Gly
290 295 300
Val Leu Ala Leu Phe Phe Pro Ala Leu Val Ser Gly Val Gly Ile Thr
305 310 315 320
Phe Ser Phe Leu Ile Phe Ala Val Val Gly Val Ile Ala Leu Ala Phe
325 330 335
Val Thr Lys Phe Val Pro Glu Thr Arg Gly Arg Ser Leu Glu Glu Leu
340 345 350
Asp His Ala Ala Phe Thr Gly Gln Ile Phe Lys Lys Ala
355 360 365
<210> 547
<211> 2013
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1990)
<223> RXN02395
<400> 547
aaacaggaat atttaactcg acttcttaaa aaagctctat acgtaaatat cttgcccatc 60
cagcaccacc tcattgtggt gcacaatgga gaggacacac atg tcc acc aac tct 115
Met Ser Thr Asn Ser
1 5
ggc aat aac ttg cct gaa tcc caa gag tca ccc gag gaa cct cat tat 163
Gly Asn Asn Leu Pro Glu Ser Gln Glu Ser Pro Glu Glu Pro His Tyr
10 15 20
cct cac gac acc cac cca ggc cta gtt cct ggc att tcg gtc gat gct 211
Pro His Asp Thr His Pro Gly Leu Val Pro Gly Ile Ser Val Asp Ala
25 30 35
caa cgc aac aag ttc gga ctc gac aaa acc gtt ttc ggc gtc acc gca 259
Gln Arg Asn Lys Phe Gly Leu Asp Lys Thr Val Phe Gly Val Thr Ala
40 45 50
gca tta att ctg gcg ttc atc gcc tgg ggc att tcc agc cct gat tcg 307
Ala Leu Ile Leu Ala Phe Ile Ala Trp Gly Ile Ser Ser Pro Asp Ser
55 60 65
gtt tct tca gta tcg tcc acg atg ttc agt tgg gct atg acg aat act 355
Val Ser Ser Val Ser Ser Thr Met Phe Ser Trp Ala Met Thr Asn Thr
70 75 80 85
ggt tgg ctc ctc aac ttt gtc atg ctg atc ggc att ggc acc atg ctc 403
Gly Trp Leu Leu Asn Phe Val Met Leu Ile Gly Ile Gly Thr Met Leu
90 95 100
tac atc gct ttt tcg cgc tac ggc cgc atc aag ctg ggc acg gac gaa 451
Tyr Ile Ala Phe Ser Arg Tyr Gly Arg Ile Lys Leu Gly Thr Asp Glu
105 110 115
gac gaa cca gaa ttc tct cgc ttt tcc tgg att gcg atg atg ttc ggc 499
Asp Glu Pro Glu Phe Ser Arg Phe Ser Trp Ile Ala Met Met Phe Gly
120 125 130
gcc ggc atc ggt gtc ggt atc ttc ttc ttc ggt cct tcc gaa ccg ctg 547
Ala Gly Ile Gly Val Gly Ile Phe Phe Phe Gly Pro Ser Glu Pro Leu
135 140 145
tgg cat tat ctc agt ccc cca cct cac acc gtg gaa gga tct aca cct 595
Trp His Tyr Leu Ser Pro Pro Pro His Thr Val Glu Gly Ser Thr Pro
150 155 160 165
gag tcc ttg cac caa gca ctt gcg cag tcc cac ttc cac tgg ggc tta 643
Glu Ser Leu His Gln Ala Leu Ala Gln Ser His Phe His Trp Gly Leu
170 175 180
tcc gcc tgg ggg ctg tat gcc ttg gtc ggc ggc gcg ttg gcg tac tcc 691
Ser Ala Trp Gly Leu Tyr Ala Leu Val Gly Gly Ala Leu Ala Tyr Ser
185 190 195
agt tac cga cgc ggc cgc gta acc ttg atc agc tcc acc ttc cgg tca 739
Ser Tyr Arg Arg Gly Arg Val Thr Leu Ile Ser Ser Thr Phe Arg Ser
200 205 210
ctt ttc ggt gag aaa acc gaa ggt atc gcg ggt cgc ctc atc gac atg 787
Leu Phe Gly Glu Lys Thr Glu Gly Ile Ala Gly Arg Leu Ile Asp Met
215 220 225
atg gcg atc atc gcc acg ctg ttt gga acg gct gca acc ttg ggc ctt 835
Met Ala Ile Ile Ala Thr Leu Phe Gly Thr Ala Ala Thr Leu Gly Leu
230 235 240 245
tca gca att cag gtt ggt cag ggc gtg cag att att tct ggc gct tcg 883
Ser Ala Ile Gln Val Gly Gln Gly Val Gln Ile Ile Ser Gly Ala Ser
250 255 260
gaa atc acc aac aac atc ttg atc gcc atc atc gcg atc ttg acc att 931
Glu Ile Thr Asn Asn Ile Leu Ile Ala Ile Ile Ala Ile Leu Thr Ile
265 270 275
ggc ttc atc atc tcc tca gta tct ggc gtg tcc aag ggc att cgt tat 979
Gly Phe Ile Ile Ser Ser Val Ser Gly Val Ser Lys Gly Ile Arg Tyr
280 285 290
ctt tcc aac ctc aat att tcc ttg acg ctt gga ttg gtc ctg ttt gtg 1027
Leu Ser Asn Leu Asn Ile Ser Leu Thr Leu Gly Leu Val Leu Phe Val
295 300 305
ttc atc acc ggc ccc acc ttg ttc ctg ctc aac ttg atc cca tcg agt 1075
Phe Ile Thr Gly Pro Thr Leu Phe Leu Leu Asn Leu Ile Pro Ser Ser
310 315 320 325
gtg ttg gaa tat ggc agt gag ttc ttg tca atg gct ggc aag tct ttg 1123
Val Leu Glu Tyr Gly Ser Glu Phe Leu Ser Met Ala Gly Lys Ser Leu
330 335 340
tcg tgg ggt gag gaa acc att gaa ttc caa gct ggt tgg acg gcg ttc 1171
Ser Trp Gly Glu Glu Thr Ile Glu Phe Gln Ala Gly Trp Thr Ala Phe
345 350 355
tac tgg gca tgg tgg atc gca tgg act cca ttc gtg ggt atg ttc atc 1219
Tyr Trp Ala Trp Trp Ile Ala Trp Thr Pro Phe Val Gly Met Phe Ile
360 365 370
gcg cgt att tct cgc ggc cgc acc ttg cgt gaa ttc gcg ctc atc acc 1267
Ala Arg Ile Ser Arg Gly Arg Thr Leu Arg Glu Phe Ala Leu Ile Thr
375 380 385
atg gct atc ccc tcc ttc att ttg atc ctg gcg ttc acc att ttc ggt 1315
Met Ala Ile Pro Ser Phe Ile Leu Ile Leu Ala Phe Thr Ile Phe Gly
390 395 400 405
gga act gcc atc acg atg aac cgc gag aac gta gat ggt ttt gac ggc 1363
Gly Thr Ala Ile Thr Met Asn Arg Glu Asn Val Asp Gly Phe Asp Gly
410 415 420
agt tca tcc aag gaa cag gtg ctg ttt gat atg ttc agc aac ctt ccg 1411
Ser Ser Ser Lys Glu Gln Val Leu Phe Asp Met Phe Ser Asn Leu Pro
425 430 435
ctg tac tcg atc aca ccg ttc att ttg atc ttt gtg ctg gca gta ttc 1459
Leu Tyr Ser Ile Thr Pro Phe Ile Leu Ile Phe Val Leu Ala Val Phe
440 445 450
ttt gtt acc tct gcc gat tcc gcc tcc gtg gtg atg gga acg atg agc 1507
Phe Val Thr Ser Ala Asp Ser Ala Ser Val Val Met Gly Thr Met Ser
455 460 465
tcc caa ggt aac cct gca cca aac aaa tta atc gtg gtg ttc tgg gga 1555
Ser Gln Gly Asn Pro Ala Pro Asn Lys Leu Ile Val Val Phe Trp Gly
470 475 480 485
ctg tgc atg atg ggc atc gcg gtg gtc atg ctg ctt act ggt ggc gaa 1603
Leu Cys Met Met Gly Ile Ala Val Val Met Leu Leu Thr Gly Gly Glu
490 495 500
tcc gcg ctg act ggt ctg cag aac ctc acc att ttg atc gcc att ccg 1651
Ser Ala Leu Thr Gly Leu Gln Asn Leu Thr Ile Leu Ile Ala Ile Pro
505 510 515
ttt gcg ctg gtg ttg atc gtg atg gct att gcc ttt att aag gac tta 1699
Phe Ala Leu Val Leu Ile Val Met Ala Ile Ala Phe Ile Lys Asp Leu
520 525 530
tcc aca gac cca gcc gct att cga caa cgc tat gca aag gca gcc atc 1747
Ser Thr Asp Pro Ala Ala Ile Arg Gln Arg Tyr Ala Lys Ala Ala Ile
535 540 545
tct aac gcg gtg gtt cgt ggc ttg gaa gaa cac ggc gac gac ttc gag 1795
Ser Asn Ala Val Val Arg Gly Leu Glu Glu His Gly Asp Asp Phe Glu
550 555 560 565
ctc tcc atc gaa cct gca gag gaa ggt cgt gga gcg ggt gct acc ttc 1843
Leu Ser Ile Glu Pro Ala Glu Glu Gly Arg Gly Ala Gly Ala Thr Phe
570 575 580
gat tcc acc gct gat cac atc acc gac tgg tat cag cgc acc gac gaa 1891
Asp Ser Thr Ala Asp His Ile Thr Asp Trp Tyr Gln Arg Thr Asp Glu
585 590 595
gaa ggc aat gat gtt gat tat gac ttc acc acc ggc aaa tgg gcc gat 1939
Glu Gly Asn Asp Val Asp Tyr Asp Phe Thr Thr Gly Lys Trp Ala Asp
600 605 610
ggt tgg aca ccg gaa tcg acc gaa gaa ggc gaa gtg gac gcg aaa aag 1987
Gly Trp Thr Pro Glu Ser Thr Glu Glu Gly Glu Val Asp Ala Lys Lys
615 620 625
gat taaaaaataa cgactggctg gga 2013
Asp
630
<210> 548
<211> 630
<212> PRT
<213> Corynebacterium glutamicum
<400> 548
Met Ser Thr Asn Ser Gly Asn Asn Leu Pro Glu Ser Gln Glu Ser Pro
1 5 10 15
Glu Glu Pro His Tyr Pro His Asp Thr His Pro Gly Leu Val Pro Gly
20 25 30
Ile Ser Val Asp Ala Gln Arg Asn Lys Phe Gly Leu Asp Lys Thr Val
35 40 45
Phe Gly Val Thr Ala Ala Leu Ile Leu Ala Phe Ile Ala Trp Gly Ile
50 55 60
Ser Ser Pro Asp Ser Val Ser Ser Val Ser Ser Thr Met Phe Ser Trp
65 70 75 80
Ala Met Thr Asn Thr Gly Trp Leu Leu Asn Phe Val Met Leu Ile Gly
85 90 95
Ile Gly Thr Met Leu Tyr Ile Ala Phe Ser Arg Tyr Gly Arg Ile Lys
100 105 110
Leu Gly Thr Asp Glu Asp Glu Pro Glu Phe Ser Arg Phe Ser Trp Ile
115 120 125
Ala Met Met Phe Gly Ala Gly Ile Gly Val Gly Ile Phe Phe Phe Gly
130 135 140
Pro Ser Glu Pro Leu Trp His Tyr Leu Ser Pro Pro Pro His Thr Val
145 150 155 160
Glu Gly Ser Thr Pro Glu Ser Leu His Gln Ala Leu Ala Gln Ser His
165 170 175
Phe His Trp Gly Leu Ser Ala Trp Gly Leu Tyr Ala Leu Val Gly Gly
180 185 190
Ala Leu Ala Tyr Ser Ser Tyr Arg Arg Gly Arg Val Thr Leu Ile Ser
195 200 205
Ser Thr Phe Arg Ser Leu Phe Gly Glu Lys Thr Glu Gly Ile Ala Gly
210 215 220
Arg Leu Ile Asp Met Met Ala Ile Ile Ala Thr Leu Phe Gly Thr Ala
225 230 235 240
Ala Thr Leu Gly Leu Ser Ala Ile Gln Val Gly Gln Gly Val Gln Ile
245 250 255
Ile Ser Gly Ala Ser Glu Ile Thr Asn Asn Ile Leu Ile Ala Ile Ile
260 265 270
Ala Ile Leu Thr Ile Gly Phe Ile Ile Ser Ser Val Ser Gly Val Ser
275 280 285
Lys Gly Ile Arg Tyr Leu Ser Asn Leu Asn Ile Ser Leu Thr Leu Gly
290 295 300
Leu Val Leu Phe Val Phe Ile Thr Gly Pro Thr Leu Phe Leu Leu Asn
305 310 315 320
Leu Ile Pro Ser Ser Val Leu Glu Tyr Gly Ser Glu Phe Leu Ser Met
325 330 335
Ala Gly Lys Ser Leu Ser Trp Gly Glu Glu Thr Ile Glu Phe Gln Ala
340 345 350
Gly Trp Thr Ala Phe Tyr Trp Ala Trp Trp Ile Ala Trp Thr Pro Phe
355 360 365
Val Gly Met Phe Ile Ala Arg Ile Ser Arg Gly Arg Thr Leu Arg Glu
370 375 380
Phe Ala Leu Ile Thr Met Ala Ile Pro Ser Phe Ile Leu Ile Leu Ala
385 390 395 400
Phe Thr Ile Phe Gly Gly Thr Ala Ile Thr Met Asn Arg Glu Asn Val
405 410 415
Asp Gly Phe Asp Gly Ser Ser Ser Lys Glu Gln Val Leu Phe Asp Met
420 425 430
Phe Ser Asn Leu Pro Leu Tyr Ser Ile Thr Pro Phe Ile Leu Ile Phe
435 440 445
Val Leu Ala Val Phe Phe Val Thr Ser Ala Asp Ser Ala Ser Val Val
450 455 460
Met Gly Thr Met Ser Ser Gln Gly Asn Pro Ala Pro Asn Lys Leu Ile
465 470 475 480
Val Val Phe Trp Gly Leu Cys Met Met Gly Ile Ala Val Val Met Leu
485 490 495
Leu Thr Gly Gly Glu Ser Ala Leu Thr Gly Leu Gln Asn Leu Thr Ile
500 505 510
Leu Ile Ala Ile Pro Phe Ala Leu Val Leu Ile Val Met Ala Ile Ala
515 520 525
Phe Ile Lys Asp Leu Ser Thr Asp Pro Ala Ala Ile Arg Gln Arg Tyr
530 535 540
Ala Lys Ala Ala Ile Ser Asn Ala Val Val Arg Gly Leu Glu Glu His
545 550 555 560
Gly Asp Asp Phe Glu Leu Ser Ile Glu Pro Ala Glu Glu Gly Arg Gly
565 570 575
Ala Gly Ala Thr Phe Asp Ser Thr Ala Asp His Ile Thr Asp Trp Tyr
580 585 590
Gln Arg Thr Asp Glu Glu Gly Asn Asp Val Asp Tyr Asp Phe Thr Thr
595 600 605
Gly Lys Trp Ala Asp Gly Trp Thr Pro Glu Ser Thr Glu Glu Gly Glu
610 615 620
Val Asp Ala Lys Lys Asp
625 630
<210> 549
<211> 2007
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1984)
<223> RXN02348
<400> 549
aaagacccga gccgaagccc tggcctgcgc atacttcctt gtcaacgctc gctgggatta 60
ggtcttttct gagcgctagc atttctccac tcaaaggagc atg ctt aac cgc atg 115
Met Leu Asn Arg Met
1 5
aaa agt gcg cgg cca aaa tca gtc gct cca aaa tcc gga caa gct tta 163
Lys Ser Ala Arg Pro Lys Ser Val Ala Pro Lys Ser Gly Gln Ala Leu
10 15 20
ctc act ctc ggt gcc cta ggt gtt gtg ttc ggc gac atc ggc acc agc 211
Leu Thr Leu Gly Ala Leu Gly Val Val Phe Gly Asp Ile Gly Thr Ser
25 30 35
ccc ctg tac tca ctt cac act gca ttc agc atg cag cac aac aaa gtc 259
Pro Leu Tyr Ser Leu His Thr Ala Phe Ser Met Gln His Asn Lys Val
40 45 50
gaa gtc act cag gaa aat gtg tac ggc atc atc tcc atg gtg ttg tgg 307
Glu Val Thr Gln Glu Asn Val Tyr Gly Ile Ile Ser Met Val Leu Trp
55 60 65
acc atc act ttg atc gtc acc gtc aaa tac gtc atg ctg gtc acc cga 355
Thr Ile Thr Leu Ile Val Thr Val Lys Tyr Val Met Leu Val Thr Arg
70 75 80 85
gct gac aac caa gga caa ggt ggc atc ctg gcg ctc gtt gct ttg ctg 403
Ala Asp Asn Gln Gly Gln Gly Gly Ile Leu Ala Leu Val Ala Leu Leu
90 95 100
aaa aac cgt ggg cac tgg gga aaa ttc gtg gca gta gcc ggc atg ttg 451
Lys Asn Arg Gly His Trp Gly Lys Phe Val Ala Val Ala Gly Met Leu
105 110 115
ggc gcc gca ttg ttt tat ggc gat gtg gtg atc acc ccg gcg atc tct 499
Gly Ala Ala Leu Phe Tyr Gly Asp Val Val Ile Thr Pro Ala Ile Ser
120 125 130
gtt ctc agc gca aca gaa ggc ttg acg gtt atc tcc cca agc ttt gag 547
Val Leu Ser Ala Thr Glu Gly Leu Thr Val Ile Ser Pro Ser Phe Glu
135 140 145
cgc ttc att ctg ccc gta tct ctc gca gtt ctg atc gct att ttt gca 595
Arg Phe Ile Leu Pro Val Ser Leu Ala Val Leu Ile Ala Ile Phe Ala
150 155 160 165
atc caa ccg ctc ggt aca gaa aaa gtc ggc aaa gcc ttc ggc ccc atc 643
Ile Gln Pro Leu Gly Thr Glu Lys Val Gly Lys Ala Phe Gly Pro Ile
170 175 180
atg ttg ctg tgg ttt gtc acc ctt gca gga ttg gga att ccg caa atc 691
Met Leu Leu Trp Phe Val Thr Leu Ala Gly Leu Gly Ile Pro Gln Ile
185 190 195
atc ggg cac cca gaa atc ttg cag agc ttg tct cca cat tgg gcc ctg 739
Ile Gly His Pro Glu Ile Leu Gln Ser Leu Ser Pro His Trp Ala Leu
200 205 210
cgc ttg att gtg gct gag cct ttc caa gca ttt gtg ctg ctt ggt gcc 787
Arg Leu Ile Val Ala Glu Pro Phe Gln Ala Phe Val Leu Leu Gly Ala
215 220 225
gtt gtc ctg aca gta acg ggt gcg gaa gcg ctc tac gct gat atg ggc 835
Val Val Leu Thr Val Thr Gly Ala Glu Ala Leu Tyr Ala Asp Met Gly
230 235 240 245
cat ttt ggg gcg agg cca atc aga gtg gcg tgg ttt tgc gtc gtc atg 883
His Phe Gly Ala Arg Pro Ile Arg Val Ala Trp Phe Cys Val Val Met
250 255 260
cct gct tta atc ttg acg tat ttg ggg cag ggc gcc ttg gtg atc aac 931
Pro Ala Leu Ile Leu Thr Tyr Leu Gly Gln Gly Ala Leu Val Ile Asn
265 270 275
cag cct gaa gcg gtg cgc aac ccc atg ttt tat ctc gcg ccg gaa ggt 979
Gln Pro Glu Ala Val Arg Asn Pro Met Phe Tyr Leu Ala Pro Glu Gly
280 285 290
ctg cgg att ccg ttg gtt att ttg gcg acc atc gct acg gtg atc gca 1027
Leu Arg Ile Pro Leu Val Ile Leu Ala Thr Ile Ala Thr Val Ile Ala
295 300 305
tcg cag gcc gtg att tct ggt gcg tat tca ttg acc aag cag gcc gtg 1075
Ser Gln Ala Val Ile Ser Gly Ala Tyr Ser Leu Thr Lys Gln Ala Val
310 315 320 325
aat ttg aaa ctg ctg cca cgc atg gtg atc cgg cat acc tcc cgc aaa 1123
Asn Leu Lys Leu Leu Pro Arg Met Val Ile Arg His Thr Ser Arg Lys
330 335 340
gag gaa ggc cag atc tat atg cca ctg gtt aat gga ttg ctg ttt gta 1171
Glu Glu Gly Gln Ile Tyr Met Pro Leu Val Asn Gly Leu Leu Phe Val
345 350 355
tcc gtg atg gtt gtg gtg ctg gta ttc cga tcc tct gaa agc ctc gcc 1219
Ser Val Met Val Val Val Leu Val Phe Arg Ser Ser Glu Ser Leu Ala
360 365 370
agc gcg tac gga ctt gca gtg acc gga acc ttg gtg ctg gtc agc gtc 1267
Ser Ala Tyr Gly Leu Ala Val Thr Gly Thr Leu Val Leu Val Ser Val
375 380 385
ctg tat ctg atc tat gtt cac acc aca tgg tgg aaa aca gcg ctg ttc 1315
Leu Tyr Leu Ile Tyr Val His Thr Thr Trp Trp Lys Thr Ala Leu Phe
390 395 400 405
att gtg ctc atc ggt att cca gaa gta ctt cta ttc gcc tcg aac acc 1363
Ile Val Leu Ile Gly Ile Pro Glu Val Leu Leu Phe Ala Ser Asn Thr
410 415 420
acg aaa att cac gac ggt ggc tgg ctt cca cta ctt att gcg gcc gtg 1411
Thr Lys Ile His Asp Gly Gly Trp Leu Pro Leu Leu Ile Ala Ala Val
425 430 435
ctc atc gtg gtg atg cgg acc tgg gag tgg gga agt gac cgc gtc aat 1459
Leu Ile Val Val Met Arg Thr Trp Glu Trp Gly Ser Asp Arg Val Asn
440 445 450
cag gaa cgc gca gag ctg gaa ctt ccc atg gat aag ttc ttg gag aaa 1507
Gln Glu Arg Ala Glu Leu Glu Leu Pro Met Asp Lys Phe Leu Glu Lys
455 460 465
ctc gat cag cca cac aat att ggt ctg cgt aaa gtt gcc gaa gtg gca 1555
Leu Asp Gln Pro His Asn Ile Gly Leu Arg Lys Val Ala Glu Val Ala
470 475 480 485
gta ttt cca cat ggc acc agc gat act gtc ccg ttg tca ttg gtt cgc 1603
Val Phe Pro His Gly Thr Ser Asp Thr Val Pro Leu Ser Leu Val Arg
490 495 500
tgc gtg aaa gac ctc aag ctt tta tac cga gag atc gtg atc gtt cga 1651
Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu Ile Val Ile Val Arg
505 510 515
atc gtc caa gaa cac gtt ccg cac gtg cca cca gag gaa cgc gcg gaa 1699
Ile Val Gln Glu His Val Pro His Val Pro Pro Glu Glu Arg Ala Glu
520 525 530
atg gaa gtg ctc cat cac gcc ccg atc aga gtc gtg cga gtt gat ctg 1747
Met Glu Val Leu His His Ala Pro Ile Arg Val Val Arg Val Asp Leu
535 540 545
cac ctt ggt tat ttt gat gag cag aac ctg cct gag cat ctc cat gcc 1795
His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro Glu His Leu His Ala
550 555 560 565
att gac cca aca tgg gat aac gcc acc tac ttc ctg tct gcc ctg act 1843
Ile Asp Pro Thr Trp Asp Asn Ala Thr Tyr Phe Leu Ser Ala Leu Thr
570 575 580
ctt cgg agc agg ttg cct gga aag att gct ggc tgg cgt gat cgt ttg 1891
Leu Arg Ser Arg Leu Pro Gly Lys Ile Ala Gly Trp Arg Asp Arg Leu
585 590 595
tat ctt tcg atg gaa cgt aat cag gca tct cga act gag tct ttc aaa 1939
Tyr Leu Ser Met Glu Arg Asn Gln Ala Ser Arg Thr Glu Ser Phe Lys
600 605 610
ttg caa cca agc aaa acc atc acg gtt gga aca gag ctg cac ctt 1984
Leu Gln Pro Ser Lys Thr Ile Thr Val Gly Thr Glu Leu His Leu
615 620 625
taatcaggca gttgctggcc aac 2007
<210> 550
<211> 628
<212> PRT
<213> Corynebacterium glutamicum
<400> 550
Met Leu Asn Arg Met Lys Ser Ala Arg Pro Lys Ser Val Ala Pro Lys
1 5 10 15
Ser Gly Gln Ala Leu Leu Thr Leu Gly Ala Leu Gly Val Val Phe Gly
20 25 30
Asp Ile Gly Thr Ser Pro Leu Tyr Ser Leu His Thr Ala Phe Ser Met
35 40 45
Gln His Asn Lys Val Glu Val Thr Gln Glu Asn Val Tyr Gly Ile Ile
50 55 60
Ser Met Val Leu Trp Thr Ile Thr Leu Ile Val Thr Val Lys Tyr Val
65 70 75 80
Met Leu Val Thr Arg Ala Asp Asn Gln Gly Gln Gly Gly Ile Leu Ala
85 90 95
Leu Val Ala Leu Leu Lys Asn Arg Gly His Trp Gly Lys Phe Val Ala
100 105 110
Val Ala Gly Met Leu Gly Ala Ala Leu Phe Tyr Gly Asp Val Val Ile
115 120 125
Thr Pro Ala Ile Ser Val Leu Ser Ala Thr Glu Gly Leu Thr Val Ile
130 135 140
Ser Pro Ser Phe Glu Arg Phe Ile Leu Pro Val Ser Leu Ala Val Leu
145 150 155 160
Ile Ala Ile Phe Ala Ile Gln Pro Leu Gly Thr Glu Lys Val Gly Lys
165 170 175
Ala Phe Gly Pro Ile Met Leu Leu Trp Phe Val Thr Leu Ala Gly Leu
180 185 190
Gly Ile Pro Gln Ile Ile Gly His Pro Glu Ile Leu Gln Ser Leu Ser
195 200 205
Pro His Trp Ala Leu Arg Leu Ile Val Ala Glu Pro Phe Gln Ala Phe
210 215 220
Val Leu Leu Gly Ala Val Val Leu Thr Val Thr Gly Ala Glu Ala Leu
225 230 235 240
Tyr Ala Asp Met Gly His Phe Gly Ala Arg Pro Ile Arg Val Ala Trp
245 250 255
Phe Cys Val Val Met Pro Ala Leu Ile Leu Thr Tyr Leu Gly Gln Gly
260 265 270
Ala Leu Val Ile Asn Gln Pro Glu Ala Val Arg Asn Pro Met Phe Tyr
275 280 285
Leu Ala Pro Glu Gly Leu Arg Ile Pro Leu Val Ile Leu Ala Thr Ile
290 295 300
Ala Thr Val Ile Ala Ser Gln Ala Val Ile Ser Gly Ala Tyr Ser Leu
305 310 315 320
Thr Lys Gln Ala Val Asn Leu Lys Leu Leu Pro Arg Met Val Ile Arg
325 330 335
His Thr Ser Arg Lys Glu Glu Gly Gln Ile Tyr Met Pro Leu Val Asn
340 345 350
Gly Leu Leu Phe Val Ser Val Met Val Val Val Leu Val Phe Arg Ser
355 360 365
Ser Glu Ser Leu Ala Ser Ala Tyr Gly Leu Ala Val Thr Gly Thr Leu
370 375 380
Val Leu Val Ser Val Leu Tyr Leu Ile Tyr Val His Thr Thr Trp Trp
385 390 395 400
Lys Thr Ala Leu Phe Ile Val Leu Ile Gly Ile Pro Glu Val Leu Leu
405 410 415
Phe Ala Ser Asn Thr Thr Lys Ile His Asp Gly Gly Trp Leu Pro Leu
420 425 430
Leu Ile Ala Ala Val Leu Ile Val Val Met Arg Thr Trp Glu Trp Gly
435 440 445
Ser Asp Arg Val Asn Gln Glu Arg Ala Glu Leu Glu Leu Pro Met Asp
450 455 460
Lys Phe Leu Glu Lys Leu Asp Gln Pro His Asn Ile Gly Leu Arg Lys
465 470 475 480
Val Ala Glu Val Ala Val Phe Pro His Gly Thr Ser Asp Thr Val Pro
485 490 495
Leu Ser Leu Val Arg Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu
500 505 510
Ile Val Ile Val Arg Ile Val Gln Glu His Val Pro His Val Pro Pro
515 520 525
Glu Glu Arg Ala Glu Met Glu Val Leu His His Ala Pro Ile Arg Val
530 535 540
Val Arg Val Asp Leu His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro
545 550 555 560
Glu His Leu His Ala Ile Asp Pro Thr Trp Asp Asn Ala Thr Tyr Phe
565 570 575
Leu Ser Ala Leu Thr Leu Arg Ser Arg Leu Pro Gly Lys Ile Ala Gly
580 585 590
Trp Arg Asp Arg Leu Tyr Leu Ser Met Glu Arg Asn Gln Ala Ser Arg
595 600 605
Thr Glu Ser Phe Lys Leu Gln Pro Ser Lys Thr Ile Thr Val Gly Thr
610 615 620
Glu Leu His Leu
625
<210> 551
<211> 1035
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1012)
<223> RXN00297
<400> 551
aacaaggcac cggaaaacaa gcaacgcacc ttgcagaggt ggtcttaagc atcttggagc 60
aaaacaacat ggcacaataa cgatcatgca acaggtgctc atg ggt ttc acg gtg 115
Met Gly Phe Thr Val
1 5
gtg ttc atc gtc atc gga ata ggt tgg att ctc ggt aga aga gac acc 163
Val Phe Ile Val Ile Gly Ile Gly Trp Ile Leu Gly Arg Arg Asp Thr
10 15 20
ttg ggc aca cat gcc cag aaa cct ttg agc ctg ttt gtc tat tac gtg 211
Leu Gly Thr His Ala Gln Lys Pro Leu Ser Leu Phe Val Tyr Tyr Val
25 30 35
gcc acc cca gcg ttg ttg ttt gat cgg gtc acc aag tca gat acc tcg 259
Ala Thr Pro Ala Leu Leu Phe Asp Arg Val Thr Lys Ser Asp Thr Ser
40 45 50
acg att ttc tct ctg aac ttc gtg gtc att gca ctc tct gcg ttg atc 307
Thr Ile Phe Ser Leu Asn Phe Val Val Ile Ala Leu Ser Ala Leu Ile
55 60 65
gta ggt ttc ctg ttt ttc cta ctc atg cgg ttc gtg atc aaa aga act 355
Val Gly Phe Leu Phe Phe Leu Leu Met Arg Phe Val Ile Lys Arg Thr
70 75 80 85
gcc gca gta tcg gtg atc ggc atg cta gct gcg tcc tac gcc aac gcc 403
Ala Ala Val Ser Val Ile Gly Met Leu Ala Ala Ser Tyr Ala Asn Ala
90 95 100
ggt aac ctg ggt atc cct ttg gca gcc tat att ttg gat gat ttc acc 451
Gly Asn Leu Gly Ile Pro Leu Ala Ala Tyr Ile Leu Asp Asp Phe Thr
105 110 115
gtg gtg att ccc gtg att ttg ttc cag gtg gcg ttc tac gca ccg atc 499
Val Val Ile Pro Val Ile Leu Phe Gln Val Ala Phe Tyr Ala Pro Ile
120 125 130
acc atg acc atc atg gag atg ctg acc aac aag aaa tcc acc aac ttg 547
Thr Met Thr Ile Met Glu Met Leu Thr Asn Lys Lys Ser Thr Asn Leu
135 140 145
gtg cgc aac ctc ctg gtc acg cca cta acc aac acc atg gtg ctc gca 595
Val Arg Asn Leu Leu Val Thr Pro Leu Thr Asn Thr Met Val Leu Ala
150 155 160 165
gcg att gcc ggt att gct gtg tct ttg act tcg atg agc gtg ccc gtg 643
Ala Ile Ala Gly Ile Ala Val Ser Leu Thr Ser Met Ser Val Pro Val
170 175 180
gtg att gct cag cca gtg gaa atg ttg gcg aat gct tca gtg cca ctg 691
Val Ile Ala Gln Pro Val Glu Met Leu Ala Asn Ala Ser Val Pro Leu
185 190 195
gct ttg gtg gtg ttc gga ctg tcc ttg tcc aag agc aag atc ctg gaa 739
Ala Leu Val Val Phe Gly Leu Ser Leu Ser Lys Ser Lys Ile Leu Glu
200 205 210
aag ggg cag gta tcc agg cgc gat gtg ttt acg gcg gca ctg ttc aag 787
Lys Gly Gln Val Ser Arg Arg Asp Val Phe Thr Ala Ala Leu Phe Lys
215 220 225
aat gtt ctg cac cca att gtt gcg gga ctt tta gcc tta gcc ttt ggt 835
Asn Val Leu His Pro Ile Val Ala Gly Leu Leu Ala Leu Ala Phe Gly
230 235 240 245
atg gaa ggt act gcc ttg ttg tcg gcg gtg att ctc ggt gca ctg cca 883
Met Glu Gly Thr Ala Leu Leu Ser Ala Val Ile Leu Gly Ala Leu Pro
250 255 260
aca gcg cag aat gtc tac acc tac gcg ttg cga ttt aga aca gct gaa 931
Thr Ala Gln Asn Val Tyr Thr Tyr Ala Leu Arg Phe Arg Thr Ala Glu
265 270 275
tcg atg gcg aga gac aca ggg gtg gtc acc aca ctc att tcc ttc ccc 979
Ser Met Ala Arg Asp Thr Gly Val Val Thr Thr Leu Ile Ser Phe Pro
280 285 290
gta ttg gtg gcg gtc tcc att atc ttt gga tct tagggttagc attagtggtc 1032
Val Leu Val Ala Val Ser Ile Ile Phe Gly Ser
295 300
atg 1035
<210> 552
<211> 304
<212> PRT
<213> Corynebacterium glutamicum
<400> 552
Met Gly Phe Thr Val Val Phe Ile Val Ile Gly Ile Gly Trp Ile Leu
1 5 10 15
Gly Arg Arg Asp Thr Leu Gly Thr His Ala Gln Lys Pro Leu Ser Leu
20 25 30
Phe Val Tyr Tyr Val Ala Thr Pro Ala Leu Leu Phe Asp Arg Val Thr
35 40 45
Lys Ser Asp Thr Ser Thr Ile Phe Ser Leu Asn Phe Val Val Ile Ala
50 55 60
Leu Ser Ala Leu Ile Val Gly Phe Leu Phe Phe Leu Leu Met Arg Phe
65 70 75 80
Val Ile Lys Arg Thr Ala Ala Val Ser Val Ile Gly Met Leu Ala Ala
85 90 95
Ser Tyr Ala Asn Ala Gly Asn Leu Gly Ile Pro Leu Ala Ala Tyr Ile
100 105 110
Leu Asp Asp Phe Thr Val Val Ile Pro Val Ile Leu Phe Gln Val Ala
115 120 125
Phe Tyr Ala Pro Ile Thr Met Thr Ile Met Glu Met Leu Thr Asn Lys
130 135 140
Lys Ser Thr Asn Leu Val Arg Asn Leu Leu Val Thr Pro Leu Thr Asn
145 150 155 160
Thr Met Val Leu Ala Ala Ile Ala Gly Ile Ala Val Ser Leu Thr Ser
165 170 175
Met Ser Val Pro Val Val Ile Ala Gln Pro Val Glu Met Leu Ala Asn
180 185 190
Ala Ser Val Pro Leu Ala Leu Val Val Phe Gly Leu Ser Leu Ser Lys
195 200 205
Ser Lys Ile Leu Glu Lys Gly Gln Val Ser Arg Arg Asp Val Phe Thr
210 215 220
Ala Ala Leu Phe Lys Asn Val Leu His Pro Ile Val Ala Gly Leu Leu
225 230 235 240
Ala Leu Ala Phe Gly Met Glu Gly Thr Ala Leu Leu Ser Ala Val Ile
245 250 255
Leu Gly Ala Leu Pro Thr Ala Gln Asn Val Tyr Thr Tyr Ala Leu Arg
260 265 270
Phe Arg Thr Ala Glu Ser Met Ala Arg Asp Thr Gly Val Val Thr Thr
275 280 285
Leu Ile Ser Phe Pro Val Leu Val Ala Val Ser Ile Ile Phe Gly Ser
290 295 300
<210> 553
<211> 353
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(343)
<223> RXN03103
<400> 553
atcttcagag tcacttcttt cagtgtcatt tttctcggcc ctaatccccc gctggagttc 60
aatcagcgat tgcaaccttt tagatatata aggagacaac atg tct gca aag cgt 115
Met Ser Ala Lys Arg
1 5
act ttt acc cgt atc ggt gcg att ctt gga gca act gca ctt gcc gga 163
Thr Phe Thr Arg Ile Gly Ala Ile Leu Gly Ala Thr Ala Leu Ala Gly
10 15 20
gtt acc ctc acc gcc tgt ggt gat tca agc ggt ggc gac gga ttc ctc 211
Val Thr Leu Thr Ala Cys Gly Asp Ser Ser Gly Gly Asp Gly Phe Leu
25 30 35
gca gcc att gaa aat ggt tct gtc aat gtc ggc acc aaa tac gat cag 259
Ala Ala Ile Glu Asn Gly Ser Val Asn Val Gly Thr Lys Tyr Asp Gln
40 45 50
cct ggt ctt ggc ctc cgc aac cca gac aac tcc atg agc ggt ctc gac 307
Pro Gly Leu Gly Leu Arg Asn Pro Asp Asn Ser Met Ser Gly Leu Asp
55 60 65
gtg gat gtt gct gaa tac gta att caa ctc cat cgc tgatgacaag 353
Val Asp Val Ala Glu Tyr Val Ile Gln Leu His Arg
70 75 80
<210> 554
<211> 81
<212> PRT
<213> Corynebacterium glutamicum
<400> 554
Met Ser Ala Lys Arg Thr Phe Thr Arg Ile Gly Ala Ile Leu Gly Ala
1 5 10 15
Thr Ala Leu Ala Gly Val Thr Leu Thr Ala Cys Gly Asp Ser Ser Gly
20 25 30
Gly Asp Gly Phe Leu Ala Ala Ile Glu Asn Gly Ser Val Asn Val Gly
35 40 45
Thr Lys Tyr Asp Gln Pro Gly Leu Gly Leu Arg Asn Pro Asp Asn Ser
50 55 60
Met Ser Gly Leu Asp Val Asp Val Ala Glu Tyr Val Ile Gln Leu His
65 70 75 80
Arg
<210> 555
<211> 695
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(672)
<223> RXN02993
<400> 555
gtt gct gaa tac gta gtc aac tcc atc gct gat gac aag ggc tgg gat 48
Val Ala Glu Tyr Val Val Asn Ser Ile Ala Asp Asp Lys Gly Trp Asp
1 5 10 15
cac ccc acc atc gaa tgg cgt gaa tcc cct tct gcg cag cgt gaa acc 96
His Pro Thr Ile Glu Trp Arg Glu Ser Pro Ser Ala Gln Arg Glu Thr
20 25 30
ctc att caa aac ggt gag gta gac atg atc gca gca acc tac tcc atc 144
Leu Ile Gln Asn Gly Glu Val Asp Met Ile Ala Ala Thr Tyr Ser Ile
35 40 45
aac gct ggc cgt tca gag tcc gtc aac ttc ggt ggc cca tac ctg ctt 192
Asn Ala Gly Arg Ser Glu Ser Val Asn Phe Gly Gly Pro Tyr Leu Leu
50 55 60
acc cac cag gct ctg ctt gtt cgc caa gat gac gat cgc att gaa acc 240
Thr His Gln Ala Leu Leu Val Arg Gln Asp Asp Asp Arg Ile Glu Thr
65 70 75 80
ctc gag gac ttg gat aac ggt ttg atc ctg tgc tcc gtt tcc gga tcc 288
Leu Glu Asp Leu Asp Asn Gly Leu Ile Leu Cys Ser Val Ser Gly Ser
85 90 95
act cca gct cag aag gtc aag gat gtc ctc cca ggc gtt cag ctc caa 336
Thr Pro Ala Gln Lys Val Lys Asp Val Leu Pro Gly Val Gln Leu Gln
100 105 110
gaa tac gac acc tac tct tcc tgt gtt gag gca ctg tcc cag ggc aac 384
Glu Tyr Asp Thr Tyr Ser Ser Cys Val Glu Ala Leu Ser Gln Gly Asn
115 120 125
gtt gac gcc ctg acc act gac gcc acc atc ctc ttc ggc tac tcc cag 432
Val Asp Ala Leu Thr Thr Asp Ala Thr Ile Leu Phe Gly Tyr Ser Gln
130 135 140
cag tac gaa ggc gac ttc cgc gtt gtg gaa atg gaa aag gac ggc gag 480
Gln Tyr Glu Gly Asp Phe Arg Val Val Glu Met Glu Lys Asp Gly Glu
145 150 155 160
cca ttc acc gac gag tac tac ggc att ggc ctg aag aag gat gac cag 528
Pro Phe Thr Asp Glu Tyr Tyr Gly Ile Gly Leu Lys Lys Asp Asp Gln
165 170 175
gaa ggc acc gac gct atc aac gcc gca ctt gag cgc atg tac gct gac 576
Glu Gly Thr Asp Ala Ile Asn Ala Ala Leu Glu Arg Met Tyr Ala Asp
180 185 190
ggc acc ttc cag cga ctg ctc acc gag aac ctc ggt gaa gac tcc gtg 624
Gly Thr Phe Gln Arg Leu Leu Thr Glu Asn Leu Gly Glu Asp Ser Val
195 200 205
gtt gtt gaa gaa ggc acc cca ggt gac ctc tcc ttc ctc gac gca agc 672
Val Val Glu Glu Gly Thr Pro Gly Asp Leu Ser Phe Leu Asp Ala Ser
210 215 220
tagtgtgacg gcttttaaaa gcc 695
<210> 556
<211> 224
<212> PRT
<213> Corynebacterium glutamicum
<400> 556
Val Ala Glu Tyr Val Val Asn Ser Ile Ala Asp Asp Lys Gly Trp Asp
1 5 10 15
His Pro Thr Ile Glu Trp Arg Glu Ser Pro Ser Ala Gln Arg Glu Thr
20 25 30
Leu Ile Gln Asn Gly Glu Val Asp Met Ile Ala Ala Thr Tyr Ser Ile
35 40 45
Asn Ala Gly Arg Ser Glu Ser Val Asn Phe Gly Gly Pro Tyr Leu Leu
50 55 60
Thr His Gln Ala Leu Leu Val Arg Gln Asp Asp Asp Arg Ile Glu Thr
65 70 75 80
Leu Glu Asp Leu Asp Asn Gly Leu Ile Leu Cys Ser Val Ser Gly Ser
85 90 95
Thr Pro Ala Gln Lys Val Lys Asp Val Leu Pro Gly Val Gln Leu Gln
100 105 110
Glu Tyr Asp Thr Tyr Ser Ser Cys Val Glu Ala Leu Ser Gln Gly Asn
115 120 125
Val Asp Ala Leu Thr Thr Asp Ala Thr Ile Leu Phe Gly Tyr Ser Gln
130 135 140
Gln Tyr Glu Gly Asp Phe Arg Val Val Glu Met Glu Lys Asp Gly Glu
145 150 155 160
Pro Phe Thr Asp Glu Tyr Tyr Gly Ile Gly Leu Lys Lys Asp Asp Gln
165 170 175
Glu Gly Thr Asp Ala Ile Asn Ala Ala Leu Glu Arg Met Tyr Ala Asp
180 185 190
Gly Thr Phe Gln Arg Leu Leu Thr Glu Asn Leu Gly Glu Asp Ser Val
195 200 205
Val Val Glu Glu Gly Thr Pro Gly Asp Leu Ser Phe Leu Asp Ala Ser
210 215 220
<210> 557
<211> 1590
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1567)
<223> RXN00349
<400> 557
tgtgtacatc acaatggaat tcggggctag agtatctggt gaaccgtgca taaacgacct 60
gtgattggac tctttttcct tgcaaaatgt tttccagcgg atg ttg agt ttt gcg 115
Met Leu Ser Phe Ala
1 5
acc ctt cgt ggc cgc att tca aca gtt gac gct gca aaa gcc gca cct 163
Thr Leu Arg Gly Arg Ile Ser Thr Val Asp Ala Ala Lys Ala Ala Pro
10 15 20
ccg cca tcg cca cta gcc ccg att gat ctc act gac cat agt caa gtg 211
Pro Pro Ser Pro Leu Ala Pro Ile Asp Leu Thr Asp His Ser Gln Val
25 30 35
gcc ggt gtg atg aat ttg gct gcg aga att ggc gat att ttg ctt tct 259
Ala Gly Val Met Asn Leu Ala Ala Arg Ile Gly Asp Ile Leu Leu Ser
40 45 50
tca ggt acg tca aat agt gac acc aag gta caa gtt cga gca gtg acc 307
Ser Gly Thr Ser Asn Ser Asp Thr Lys Val Gln Val Arg Ala Val Thr
55 60 65
tct gcg tac ggt ttg tac tac acg cac gtg gat atc acg ttg aat acg 355
Ser Ala Tyr Gly Leu Tyr Tyr Thr His Val Asp Ile Thr Leu Asn Thr
70 75 80 85
atc acc atc ttc acc aac atc ggt gtg gag agg aag atg ccg gtc aac 403
Ile Thr Ile Phe Thr Asn Ile Gly Val Glu Arg Lys Met Pro Val Asn
90 95 100
gtg ttt cat gtt gta ggc aag ttg gac acc aac ttc tcc aaa ctg tct 451
Val Phe His Val Val Gly Lys Leu Asp Thr Asn Phe Ser Lys Leu Ser
105 110 115
gag gtt gac cgt ttg atc cgt tcc att cag gct ggt gcg acc ccg cct 499
Glu Val Asp Arg Leu Ile Arg Ser Ile Gln Ala Gly Ala Thr Pro Pro
120 125 130
gag gtt gcc gag aaa atc ctg gac gag ttg gag caa tcc cct gcg tct 547
Glu Val Ala Glu Lys Ile Leu Asp Glu Leu Glu Gln Ser Pro Ala Ser
135 140 145
tat ggt ttc cct gtt gcg ttg ctt ggc tgg gca atg atg ggt ggt gct 595
Tyr Gly Phe Pro Val Ala Leu Leu Gly Trp Ala Met Met Gly Gly Ala
150 155 160 165
gtt gct gtg ctg ttg ggt ggt gga tgg cag gtt tcc cta att gct ttt 643
Val Ala Val Leu Leu Gly Gly Gly Trp Gln Val Ser Leu Ile Ala Phe
170 175 180
att acc gcg ttc acg atc att gcc acg acg tca ttt ttg gga aag aag 691
Ile Thr Ala Phe Thr Ile Ile Ala Thr Thr Ser Phe Leu Gly Lys Lys
185 190 195
ggt ttg cct act ttc ttc caa aat gtt gtt ggt ggt ttt att gcc acg 739
Gly Leu Pro Thr Phe Phe Gln Asn Val Val Gly Gly Phe Ile Ala Thr
200 205 210
ctg cct gca tcg att gct tat tct ttg gcg ttg caa ttt ggt ctt gag 787
Leu Pro Ala Ser Ile Ala Tyr Ser Leu Ala Leu Gln Phe Gly Leu Glu
215 220 225
atc aaa ccg agc cag atc atc gca tct gga att gtt gtg ctg ttg gca 835
Ile Lys Pro Ser Gln Ile Ile Ala Ser Gly Ile Val Val Leu Leu Ala
230 235 240 245
ggt ttg aca ctc gtg caa tct ctg cag gac ggc atc acg ggc gct ccg 883
Gly Leu Thr Leu Val Gln Ser Leu Gln Asp Gly Ile Thr Gly Ala Pro
250 255 260
gtg aca gca agt gca cga ttt ttc gaa aca ctc ctg ttt acc ggc ggc 931
Val Thr Ala Ser Ala Arg Phe Phe Glu Thr Leu Leu Phe Thr Gly Gly
265 270 275
att gtt gct ggc gtg ggt ttg ggc att cag ctt tct gaa atc ttg cat 979
Ile Val Ala Gly Val Gly Leu Gly Ile Gln Leu Ser Glu Ile Leu His
280 285 290
gtc atg ttg cct gcc atg gag tcc gct gca gca cct aat tat tcg tct 1027
Val Met Leu Pro Ala Met Glu Ser Ala Ala Ala Pro Asn Tyr Ser Ser
295 300 305
aca ttc gcc cgc att atc gct ggt ggc gtc acc gca gcg gcc ttc gca 1075
Thr Phe Ala Arg Ile Ile Ala Gly Gly Val Thr Ala Ala Ala Phe Ala
310 315 320 325
gtg ggt tgt tac gcg gag tgg tcc tcg gtg att att gcg ggg ctt act 1123
Val Gly Cys Tyr Ala Glu Trp Ser Ser Val Ile Ile Ala Gly Leu Thr
330 335 340
gcg ctg atg ggt tct gcg ttt tat tac ctc ttc gtt gtt tat tta ggc 1171
Ala Leu Met Gly Ser Ala Phe Tyr Tyr Leu Phe Val Val Tyr Leu Gly
345 350 355
ccc gtc tct gcc gct gcg att gct gca aca gca gtt ggt ttc act ggt 1219
Pro Val Ser Ala Ala Ala Ile Ala Ala Thr Ala Val Gly Phe Thr Gly
360 365 370
ggt ttg ctt gcc cgt cga ttc ttg att cca ccg ttg att gtg gcg att 1267
Gly Leu Leu Ala Arg Arg Phe Leu Ile Pro Pro Leu Ile Val Ala Ile
375 380 385
gcc ggc atc aca cca atg ctt cca ggt cta gca att tac cgc gga atg 1315
Ala Gly Ile Thr Pro Met Leu Pro Gly Leu Ala Ile Tyr Arg Gly Met
390 395 400 405
tac gcc acc ctg aat gat caa aca ctc atg ggt ttc acc aac att gcg 1363
Tyr Ala Thr Leu Asn Asp Gln Thr Leu Met Gly Phe Thr Asn Ile Ala
410 415 420
gtt gct tta gcc act gct tca tca ctt gcc gct ggc gtg gtt ttg ggt 1411
Val Ala Leu Ala Thr Ala Ser Ser Leu Ala Ala Gly Val Val Leu Gly
425 430 435
gag tgg att gcc cgc agg cta cgt cgt cca cca cgc ttc aac cca tac 1459
Glu Trp Ile Ala Arg Arg Leu Arg Arg Pro Pro Arg Phe Asn Pro Tyr
440 445 450
cgt gca ttt acc aag gcg aat gag ttc tcc ttc cag gag gaa gct gag 1507
Arg Ala Phe Thr Lys Ala Asn Glu Phe Ser Phe Gln Glu Glu Ala Glu
455 460 465
cag aat cag cgc cgg cag aga aaa cgt cca aag act aat cag aga ttc 1555
Gln Asn Gln Arg Arg Gln Arg Lys Arg Pro Lys Thr Asn Gln Arg Phe
470 475 480 485
ggt aat aaa agg taaaaatcaa cctgcttagg cgt 1590
Gly Asn Lys Arg
<210> 558
<211> 489
<212> PRT
<213> Corynebacterium glutamicum
<400> 558
Met Leu Ser Phe Ala Thr Leu Arg Gly Arg Ile Ser Thr Val Asp Ala
1 5 10 15
Ala Lys Ala Ala Pro Pro Pro Ser Pro Leu Ala Pro Ile Asp Leu Thr
20 25 30
Asp His Ser Gln Val Ala Gly Val Met Asn Leu Ala Ala Arg Ile Gly
35 40 45
Asp Ile Leu Leu Ser Ser Gly Thr Ser Asn Ser Asp Thr Lys Val Gln
50 55 60
Val Arg Ala Val Thr Ser Ala Tyr Gly Leu Tyr Tyr Thr His Val Asp
65 70 75 80
Ile Thr Leu Asn Thr Ile Thr Ile Phe Thr Asn Ile Gly Val Glu Arg
85 90 95
Lys Met Pro Val Asn Val Phe His Val Val Gly Lys Leu Asp Thr Asn
100 105 110
Phe Ser Lys Leu Ser Glu Val Asp Arg Leu Ile Arg Ser Ile Gln Ala
115 120 125
Gly Ala Thr Pro Pro Glu Val Ala Glu Lys Ile Leu Asp Glu Leu Glu
130 135 140
Gln Ser Pro Ala Ser Tyr Gly Phe Pro Val Ala Leu Leu Gly Trp Ala
145 150 155 160
Met Met Gly Gly Ala Val Ala Val Leu Leu Gly Gly Gly Trp Gln Val
165 170 175
Ser Leu Ile Ala Phe Ile Thr Ala Phe Thr Ile Ile Ala Thr Thr Ser
180 185 190
Phe Leu Gly Lys Lys Gly Leu Pro Thr Phe Phe Gln Asn Val Val Gly
195 200 205
Gly Phe Ile Ala Thr Leu Pro Ala Ser Ile Ala Tyr Ser Leu Ala Leu
210 215 220
Gln Phe Gly Leu Glu Ile Lys Pro Ser Gln Ile Ile Ala Ser Gly Ile
225 230 235 240
Val Val Leu Leu Ala Gly Leu Thr Leu Val Gln Ser Leu Gln Asp Gly
245 250 255
Ile Thr Gly Ala Pro Val Thr Ala Ser Ala Arg Phe Phe Glu Thr Leu
260 265 270
Leu Phe Thr Gly Gly Ile Val Ala Gly Val Gly Leu Gly Ile Gln Leu
275 280 285
Ser Glu Ile Leu His Val Met Leu Pro Ala Met Glu Ser Ala Ala Ala
290 295 300
Pro Asn Tyr Ser Ser Thr Phe Ala Arg Ile Ile Ala Gly Gly Val Thr
305 310 315 320
Ala Ala Ala Phe Ala Val Gly Cys Tyr Ala Glu Trp Ser Ser Val Ile
325 330 335
Ile Ala Gly Leu Thr Ala Leu Met Gly Ser Ala Phe Tyr Tyr Leu Phe
340 345 350
Val Val Tyr Leu Gly Pro Val Ser Ala Ala Ala Ile Ala Ala Thr Ala
355 360 365
Val Gly Phe Thr Gly Gly Leu Leu Ala Arg Arg Phe Leu Ile Pro Pro
370 375 380
Leu Ile Val Ala Ile Ala Gly Ile Thr Pro Met Leu Pro Gly Leu Ala
385 390 395 400
Ile Tyr Arg Gly Met Tyr Ala Thr Leu Asn Asp Gln Thr Leu Met Gly
405 410 415
Phe Thr Asn Ile Ala Val Ala Leu Ala Thr Ala Ser Ser Leu Ala Ala
420 425 430
Gly Val Val Leu Gly Glu Trp Ile Ala Arg Arg Leu Arg Arg Pro Pro
435 440 445
Arg Phe Asn Pro Tyr Arg Ala Phe Thr Lys Ala Asn Glu Phe Ser Phe
450 455 460
Gln Glu Glu Ala Glu Gln Asn Gln Arg Arg Gln Arg Lys Arg Pro Lys
465 470 475 480
Thr Asn Gln Arg Phe Gly Asn Lys Arg
485
<210> 559
<211> 492
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(469)
<223> RXN03095
<400> 559
aacgcctcaa ttagtgccag accttgccga ccgcagacca aacttcacca tttcaaacca 60
tccctagcca caacaacggc agttgtgcaa tgatctgcgt atg aat gca gat aag 115
Met Asn Ala Asp Lys
1 5
aaa atg tgc gga atg aac ccg gat agc caa tac gtc gaa ctt gcc gtc 163
Lys Met Cys Gly Met Asn Pro Asp Ser Gln Tyr Val Glu Leu Ala Val
10 15 20
gaa gtt ttc gga ctc ctc gcg gac gcc act cga gtt cgc atc atc ttg 211
Glu Val Phe Gly Leu Leu Ala Asp Ala Thr Arg Val Arg Ile Ile Leu
25 30 35
gca ctt cga aac agt ggt gaa ctt tcc gta aac cac ctc gcg gac atc 259
Ala Leu Arg Asn Ser Gly Glu Leu Ser Val Asn His Leu Ala Asp Ile
40 45 50
gtc gat aaa tcc ccc gca gca gtt tcc caa cac ctc gcc cgg ctg cgc 307
Val Asp Lys Ser Pro Ala Ala Val Ser Gln His Leu Ala Arg Leu Arg
55 60 65
atg gcc cga atc gtg tcc acc cgt caa gaa ggt caa cga gtt ttc tac 355
Met Ala Arg Ile Val Ser Thr Arg Gln Glu Gly Gln Arg Val Phe Tyr
70 75 80 85
aaa ctc acc aat gaa cac gca tca cag cta gtc tcc gac gct att ttt 403
Lys Leu Thr Asn Glu His Ala Ser Gln Leu Val Ser Asp Ala Ile Phe
90 95 100
cag gcg gaa cac acc att gcg gac ggc cag act ccc cca cac cac cac 451
Gln Ala Glu His Thr Ile Ala Asp Gly Gln Thr Pro Pro His His His
105 110 115
cga gaa cga gaa caa tca tgaccaccca cagtcaccaa gaa 492
Arg Glu Arg Glu Gln Ser
120
<210> 560
<211> 123
<212> PRT
<213> Corynebacterium glutamicum
<400> 560
Met Asn Ala Asp Lys Lys Met Cys Gly Met Asn Pro Asp Ser Gln Tyr
1 5 10 15
Val Glu Leu Ala Val Glu Val Phe Gly Leu Leu Ala Asp Ala Thr Arg
20 25 30
Val Arg Ile Ile Leu Ala Leu Arg Asn Ser Gly Glu Leu Ser Val Asn
35 40 45
His Leu Ala Asp Ile Val Asp Lys Ser Pro Ala Ala Val Ser Gln His
50 55 60
Leu Ala Arg Leu Arg Met Ala Arg Ile Val Ser Thr Arg Gln Glu Gly
65 70 75 80
Gln Arg Val Phe Tyr Lys Leu Thr Asn Glu His Ala Ser Gln Leu Val
85 90 95
Ser Asp Ala Ile Phe Gln Ala Glu His Thr Ile Ala Asp Gly Gln Thr
100 105 110
Pro Pro His His His Arg Glu Arg Glu Gln Ser
115 120
<210> 561
<211> 591
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(568)
<223> RXN03160
<400> 561
gagcatatgg tgcgcgcggc cgatatgctg atcaattcca accccgatcc gcacgcttaa 60
cttctgccaa aaagtcgttt tgaccataag ctaagcgatt gtg aat cga att gca 115
Val Asn Arg Ile Ala
1 5
gaa atc gca cgc agt ttc ggc gtg ctg ggc ttc agc gct ttc ggc ggc 163
Glu Ile Ala Arg Ser Phe Gly Val Leu Gly Phe Ser Ala Phe Gly Gly
10 15 20
ccc acc gcg cac ctc gga tat ttc cgc acg gaa ttc gtg gag cgg cgg 211
Pro Thr Ala His Leu Gly Tyr Phe Arg Thr Glu Phe Val Glu Arg Arg
25 30 35
cgc tgg ctg gat gat cgc caa tat tcc gag atc gta gcg ctc agc caa 259
Arg Trp Leu Asp Asp Arg Gln Tyr Ser Glu Ile Val Ala Leu Ser Gln
40 45 50
cta ctt ccc gga cct gga tcg tcg cag gtc ggt atg atg ctg ggc tac 307
Leu Leu Pro Gly Pro Gly Ser Ser Gln Val Gly Met Met Leu Gly Tyr
55 60 65
cac cgc gcc ggt ttt tcc ggc atg gcg atc gcc tgg ctc atg ttt acc 355
His Arg Ala Gly Phe Ser Gly Met Ala Ile Ala Trp Leu Met Phe Thr
70 75 80 85
tgg ccc tca ttg gcg ctc atg gcg gcg ttc gcc ctg ctt ttt gat gcg 403
Trp Pro Ser Leu Ala Leu Met Ala Ala Phe Ala Leu Leu Phe Asp Ala
90 95 100
acc tcc gcc agc tgg acg ctc ggc ctg ctc gcc gca gcg gtc gcc gtc 451
Thr Ser Ala Ser Trp Thr Leu Gly Leu Leu Ala Ala Ala Val Ala Val
105 110 115
gtt ttc aaa cgc agt cac cgg gca tgg cgc ggt tca atg gct tcc acg 499
Val Phe Lys Arg Ser His Arg Ala Trp Arg Gly Ser Met Ala Ser Thr
120 125 130
ccg ggg cgc cgg cca cca tcg ggg gtc ggc ctc ggg gca tcg cgg gtg 547
Pro Gly Arg Arg Pro Pro Ser Gly Val Gly Leu Gly Ala Ser Arg Val
135 140 145
ctc ggc cct ccc caa cgg ggt taacacacct tggggttcaa tca 591
Leu Gly Pro Pro Gln Arg Gly
150 155
<210> 562
<211> 156
<212> PRT
<213> Corynebacterium glutamicum
<400> 562
Val Asn Arg Ile Ala Glu Ile Ala Arg Ser Phe Gly Val Leu Gly Phe
1 5 10 15
Ser Ala Phe Gly Gly Pro Thr Ala His Leu Gly Tyr Phe Arg Thr Glu
20 25 30
Phe Val Glu Arg Arg Arg Trp Leu Asp Asp Arg Gln Tyr Ser Glu Ile
35 40 45
Val Ala Leu Ser Gln Leu Leu Pro Gly Pro Gly Ser Ser Gln Val Gly
50 55 60
Met Met Leu Gly Tyr His Arg Ala Gly Phe Ser Gly Met Ala Ile Ala
65 70 75 80
Trp Leu Met Phe Thr Trp Pro Ser Leu Ala Leu Met Ala Ala Phe Ala
85 90 95
Leu Leu Phe Asp Ala Thr Ser Ala Ser Trp Thr Leu Gly Leu Leu Ala
100 105 110
Ala Ala Val Ala Val Val Phe Lys Arg Ser His Arg Ala Trp Arg Gly
115 120 125
Ser Met Ala Ser Thr Pro Gly Arg Arg Pro Pro Ser Gly Val Gly Leu
130 135 140
Gly Ala Ser Arg Val Leu Gly Pro Pro Gln Arg Gly
145 150 155
<210> 563
<211> 645
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(622)
<223> RXN02955
<400> 563
atgcactggc tcccatcaaa gacgaattct tgacctcaga attccagcgt gaactctacg 60
aagcagtgcg cgccgctgat acttcaggag gtgcggcatc atg atg aat ttt aag 115
Met Met Asn Phe Lys
1 5
tcc atc gtg tgc gtc act gcc tgg cag gtg ttt agc cgc cag gtg ctg 163
Ser Ile Val Cys Val Thr Ala Trp Gln Val Phe Ser Arg Gln Val Leu
10 15 20
cac agc cca tca acg tgg tct gaa gaa cta tcc aag ctg ttg ttc gtg 211
His Ser Pro Ser Thr Trp Ser Glu Glu Leu Ser Lys Leu Leu Phe Val
25 30 35
tgg cta tct ttc gca ggt agt gcg ttc ctc ttt gga gag cgt gga cat 259
Trp Leu Ser Phe Ala Gly Ser Ala Phe Leu Phe Gly Glu Arg Gly His
40 45 50
att gcg gtt gat ttc atc gcg cgc aaa ctg cct gtt tct gcg cag cgg 307
Ile Ala Val Asp Phe Ile Ala Arg Lys Leu Pro Val Ser Ala Gln Arg
55 60 65
gtc ctg cag gtc att gtt cag ttg ttg att gtt gtt ttt gcg atc ctc 355
Val Leu Gln Val Ile Val Gln Leu Leu Ile Val Val Phe Ala Ile Leu
70 75 80 85
ggc atg atc tgg ggt ggc tac ttg gct gca tca atc gcg tgg aat cag 403
Gly Met Ile Trp Gly Gly Tyr Leu Ala Ala Ser Ile Ala Trp Asn Gln
90 95 100
cag ctc act gcg ctg cca ctt acc ttg gga tgg gtg tat gtt gtc atc 451
Gln Leu Thr Ala Leu Pro Leu Thr Leu Gly Trp Val Tyr Val Val Ile
105 110 115
ccg atc gcg ggt gtg ttc atc gcg ttg ttc gcg atc atc gat ctc atc 499
Pro Ile Ala Gly Val Phe Ile Ala Leu Phe Ala Ile Ile Asp Leu Ile
120 125 130
gaa gtg gcc aca ggc aag gaa gag cct tac ccc ctt gtt gat gaa tca 547
Glu Val Ala Thr Gly Lys Glu Glu Pro Tyr Pro Leu Val Asp Glu Ser
135 140 145
gaa gaa cct cga gat ttg gac gag cta gag gcc caa agc gct ata gat 595
Glu Glu Pro Arg Asp Leu Asp Glu Leu Glu Ala Gln Ser Ala Ile Asp
150 155 160 165
tct gca agt tca gcg gaa ggt agg aac taatatgttg tcgccagcag 642
Ser Ala Ser Ser Ala Glu Gly Arg Asn
170
ctg 645
<210> 564
<211> 174
<212> PRT
<213> Corynebacterium glutamicum
<400> 564
Met Met Asn Phe Lys Ser Ile Val Cys Val Thr Ala Trp Gln Val Phe
1 5 10 15
Ser Arg Gln Val Leu His Ser Pro Ser Thr Trp Ser Glu Glu Leu Ser
20 25 30
Lys Leu Leu Phe Val Trp Leu Ser Phe Ala Gly Ser Ala Phe Leu Phe
35 40 45
Gly Glu Arg Gly His Ile Ala Val Asp Phe Ile Ala Arg Lys Leu Pro
50 55 60
Val Ser Ala Gln Arg Val Leu Gln Val Ile Val Gln Leu Leu Ile Val
65 70 75 80
Val Phe Ala Ile Leu Gly Met Ile Trp Gly Gly Tyr Leu Ala Ala Ser
85 90 95
Ile Ala Trp Asn Gln Gln Leu Thr Ala Leu Pro Leu Thr Leu Gly Trp
100 105 110
Val Tyr Val Val Ile Pro Ile Ala Gly Val Phe Ile Ala Leu Phe Ala
115 120 125
Ile Ile Asp Leu Ile Glu Val Ala Thr Gly Lys Glu Glu Pro Tyr Pro
130 135 140
Leu Val Asp Glu Ser Glu Glu Pro Arg Asp Leu Asp Glu Leu Glu Ala
145 150 155 160
Gln Ser Ala Ile Asp Ser Ala Ser Ser Ala Glu Gly Arg Asn
165 170
<210> 565
<211> 754
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(754)
<223> RXN03109
<400> 565
actggcgctt cccgatggtc aatcattggc ctttggtgcc caaactggcg agttgttgct 60
ccgcgcatcc cgcgaactgt atgtgcaggg cggcgagtag atg gtt gtg aag gag 115
Met Val Val Lys Glu
1 5
gtt gac gtc gaa aag caa aaa gct ggc cgg gtg cct ggt gct ata gct 163
Val Asp Val Glu Lys Gln Lys Ala Gly Arg Val Pro Gly Ala Ile Ala
10 15 20
aag cgt cgg acc gtg cgg att gtg ctg ttt gtc gcg ctg ggc gcg atc 211
Lys Arg Arg Thr Val Arg Ile Val Leu Phe Val Ala Leu Gly Ala Ile
25 30 35
gtg att gcg gcg tcg ctg tgg tcg att ctg gtc ggc caa tac acc atc 259
Val Ile Ala Ala Ser Leu Trp Ser Ile Leu Val Gly Gln Tyr Thr Ile
40 45 50
ccg att cgc gat cta cct gcg att tta gcc tcc ggt ccg acc ggt gcg 307
Pro Ile Arg Asp Leu Pro Ala Ile Leu Ala Ser Gly Pro Thr Gly Ala
55 60 65
cag acg atg gcg gaa caa gtc gtg tgg caa atc cgc atg ccg cgc atc 355
Gln Thr Met Ala Glu Gln Val Val Trp Gln Ile Arg Met Pro Arg Ile
70 75 80 85
gtg ctg gga ctg ctc gtg ggt gcc gct ttg ggc gtg gcc ggc gcg ctg 403
Val Leu Gly Leu Leu Val Gly Ala Ala Leu Gly Val Ala Gly Ala Leu
90 95 100
ttg cag gcg gtg ttt tcc aac ccg ctg gcg gaa ccg tcg atc atc ggc 451
Leu Gln Ala Val Phe Ser Asn Pro Leu Ala Glu Pro Ser Ile Ile Gly
105 110 115
gtg acc tcc ggc gcg ggc gtg ggt gct gct gcg gtg atc gtg ttt aac 499
Val Thr Ser Gly Ala Gly Val Gly Ala Ala Ala Val Ile Val Phe Asn
120 125 130
ctg aca ttt ttg ggc aca tcc acc gtc gca gtc ggc gcg ttt att acc 547
Leu Thr Phe Leu Gly Thr Ser Thr Val Ala Val Gly Ala Phe Ile Thr
135 140 145
gcg gtg atc acc acg att ttg gta tat cag ctg gcc aga agc cgt gga 595
Ala Val Ile Thr Thr Ile Leu Val Tyr Gln Leu Ala Arg Ser Arg Gly
150 155 160 165
cgt gtg caa gtg atc aac ctg atc ctg aca ggc ata gcc att aat gca 643
Arg Val Gln Val Ile Asn Leu Ile Leu Thr Gly Ile Ala Ile Asn Ala
170 175 180
gta tcc ggc gcg ctg acc tca gtt ctt gat cta cat cgc gcc gac gag 691
Val Ser Gly Ala Leu Thr Ser Val Leu Asp Leu His Arg Ala Asp Glu
185 190 195
ctc ccg cga aga aat att ttc tgc aga tgg gtt cct cac ggc tcg cat 739
Leu Pro Arg Arg Asn Ile Phe Cys Arg Trp Val Pro His Gly Ser His
200 205 210
ggc gca cgt caa cgt 754
Gly Ala Arg Gln Arg
215
<210> 566
<211> 218
<212> PRT
<213> Corynebacterium glutamicum
<400> 566
Met Val Val Lys Glu Val Asp Val Glu Lys Gln Lys Ala Gly Arg Val
1 5 10 15
Pro Gly Ala Ile Ala Lys Arg Arg Thr Val Arg Ile Val Leu Phe Val
20 25 30
Ala Leu Gly Ala Ile Val Ile Ala Ala Ser Leu Trp Ser Ile Leu Val
35 40 45
Gly Gln Tyr Thr Ile Pro Ile Arg Asp Leu Pro Ala Ile Leu Ala Ser
50 55 60
Gly Pro Thr Gly Ala Gln Thr Met Ala Glu Gln Val Val Trp Gln Ile
65 70 75 80
Arg Met Pro Arg Ile Val Leu Gly Leu Leu Val Gly Ala Ala Leu Gly
85 90 95
Val Ala Gly Ala Leu Leu Gln Ala Val Phe Ser Asn Pro Leu Ala Glu
100 105 110
Pro Ser Ile Ile Gly Val Thr Ser Gly Ala Gly Val Gly Ala Ala Ala
115 120 125
Val Ile Val Phe Asn Leu Thr Phe Leu Gly Thr Ser Thr Val Ala Val
130 135 140
Gly Ala Phe Ile Thr Ala Val Ile Thr Thr Ile Leu Val Tyr Gln Leu
145 150 155 160
Ala Arg Ser Arg Gly Arg Val Gln Val Ile Asn Leu Ile Leu Thr Gly
165 170 175
Ile Ala Ile Asn Ala Val Ser Gly Ala Leu Thr Ser Val Leu Asp Leu
180 185 190
His Arg Ala Asp Glu Leu Pro Arg Arg Asn Ile Phe Cys Arg Trp Val
195 200 205
Pro His Gly Ser His Gly Ala Arg Gln Arg
210 215
<210> 567
<211> 357
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(334)
<223> RXN02979
<400> 567
ctaggtcaag gaacttcact cggctagtcc ttagactcaa atgtgttcag acaaacactg 60
gcaccgtaag gcacgaaagt taccgaaagg actggttccc atg acc gcc cca aac 115
Met Thr Ala Pro Asn
1 5
act ctc aag caa aca act ctt cgc tct gat gag ttc tct tgc cca tcc 163
Thr Leu Lys Gln Thr Thr Leu Arg Ser Asp Glu Phe Ser Cys Pro Ser
10 15 20
tgt gtc tcc aag att gaa aac aaa ttg aat gga ttg gat ggc gtc gac 211
Cys Val Ser Lys Ile Glu Asn Lys Leu Asn Gly Leu Asp Gly Val Asp
25 30 35
aat gca gag gtg aag ttc tcc tcc gga aga atc ctt gtt gat cac gac 259
Asn Ala Glu Val Lys Phe Ser Ser Gly Arg Ile Leu Val Asp His Asp
40 45 50
ccc agc aag gtc tct atc aag gat cta gtc gct gca gtc gca gag gtt 307
Pro Ser Lys Val Ser Ile Lys Asp Leu Val Ala Ala Val Ala Glu Val
55 60 65
ggc tac acc gca aag cca tca gca atc taaaactctc agttagacca 354
Gly Tyr Thr Ala Lys Pro Ser Ala Ile
70 75
tta 357
<210> 568
<211> 78
<212> PRT
<213> Corynebacterium glutamicum
<400> 568
Met Thr Ala Pro Asn Thr Leu Lys Gln Thr Thr Leu Arg Ser Asp Glu
1 5 10 15
Phe Ser Cys Pro Ser Cys Val Ser Lys Ile Glu Asn Lys Leu Asn Gly
20 25 30
Leu Asp Gly Val Asp Asn Ala Glu Val Lys Phe Ser Ser Gly Arg Ile
35 40 45
Leu Val Asp His Asp Pro Ser Lys Val Ser Ile Lys Asp Leu Val Ala
50 55 60
Ala Val Ala Glu Val Gly Tyr Thr Ala Lys Pro Ser Ala Ile
65 70 75
<210> 569
<211> 357
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(334)
<223> RXN02987
<400> 569
gttgtttgat ccaggtcaag gaattaaccc ggaaaggacc gtatctttaa aggtgcaagc 60
acaggaacat gacgataaaa gatgaaagga cctggttacg atg acc gcc ccc gcc 115
Met Thr Ala Pro Ala
1 5
acg ctg aag aac acc acc ttg cgc tct gat gag ttc acc tgt ccg agc 163
Thr Leu Lys Asn Thr Thr Leu Arg Ser Asp Glu Phe Thr Cys Pro Ser
10 15 20
tgt gtc gcc aag atc gaa aac aag ctg aat ggt ttg gac ggc gtg gag 211
Cys Val Ala Lys Ile Glu Asn Lys Leu Asn Gly Leu Asp Gly Val Glu
25 30 35
aat gcg gag gtg aag ttc tcc tcc gga cgc atc ctg atc acc cac gac 259
Asn Ala Glu Val Lys Phe Ser Ser Gly Arg Ile Leu Ile Thr His Asp
40 45 50
cca cag aag gtc tcc gta cgt gac ctg gtc acc gcg gta gcc gag gtc 307
Pro Gln Lys Val Ser Val Arg Asp Leu Val Thr Ala Val Ala Glu Val
55 60 65
ggt tac acc gcc aag ccg tcg gcg atc tgacgcactc ccgaccccac 354
Gly Tyr Thr Ala Lys Pro Ser Ala Ile
70 75
aag 357
<210> 570
<211> 78
<212> PRT
<213> Corynebacterium glutamicum
<400> 570
Met Thr Ala Pro Ala Thr Leu Lys Asn Thr Thr Leu Arg Ser Asp Glu
1 5 10 15
Phe Thr Cys Pro Ser Cys Val Ala Lys Ile Glu Asn Lys Leu Asn Gly
20 25 30
Leu Asp Gly Val Glu Asn Ala Glu Val Lys Phe Ser Ser Gly Arg Ile
35 40 45
Leu Ile Thr His Asp Pro Gln Lys Val Ser Val Arg Asp Leu Val Thr
50 55 60
Ala Val Ala Glu Val Gly Tyr Thr Ala Lys Pro Ser Ala Ile
65 70 75
<210> 571
<211> 1041
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1018)
<223> RXN03084
<400> 571
ccacccccac gtctaagttt tcccctattt acacacacct gaccgaagct gtaaggtttg 60
cctaatcttt ttcaatctaa agtcaggata ttcacagccc atg tca tct cgc aga 115
Met Ser Ser Arg Arg
1 5
aaa ctc tcc tcc gca ctg atc gtg ctt ctc gca gca gca cta cct ctt 163
Lys Leu Ser Ser Ala Leu Ile Val Leu Leu Ala Ala Ala Leu Pro Leu
10 15 20
act gct tgt tcc tcc agc tca gaa gag gaa gca tcc acc agc tct gcg 211
Thr Ala Cys Ser Ser Ser Ser Glu Glu Glu Ala Ser Thr Ser Ser Ala
25 30 35
act cgc gaa ttc aca gac gct cac gga aca acc gaa gtt ccc gaa aat 259
Thr Arg Glu Phe Thr Asp Ala His Gly Thr Thr Glu Val Pro Glu Asn
40 45 50
cct cag cgc gtc gtt gtc ctc gag cca ctt gag cta gac acc gca atc 307
Pro Gln Arg Val Val Val Leu Glu Pro Leu Glu Leu Asp Thr Ala Ile
55 60 65
gcc ctc gga atc acc cca gtg ggt gca gct gtc gcc aac aac gtc act 355
Ala Leu Gly Ile Thr Pro Val Gly Ala Ala Val Ala Asn Asn Val Thr
70 75 80 85
ggt att cct gca tat ctc ggc gtc gat gga atc gag cct gtc ggc acc 403
Gly Ile Pro Ala Tyr Leu Gly Val Asp Gly Ile Glu Pro Val Gly Thr
90 95 100
gtt tct gag cca aat atc gaa gcg atc gct gct ctc gag ccc gac ctg 451
Val Ser Glu Pro Asn Ile Glu Ala Ile Ala Ala Leu Glu Pro Asp Leu
105 110 115
atc ctg ggc acc gat tcc cgc cac gcc gaa atc tac gac cgc ctc gaa 499
Ile Leu Gly Thr Asp Ser Arg His Ala Glu Ile Tyr Asp Arg Leu Glu
120 125 130
tcc atc gcc cca acc gtg ttc atg aca acc cat gtt gat ccg tgg aaa 547
Ser Ile Ala Pro Thr Val Phe Met Thr Thr His Val Asp Pro Trp Lys
135 140 145
gac aat gtc gtc ttc atc ggc gat gca ttg ggc aag aag cag gaa tcc 595
Asp Asn Val Val Phe Ile Gly Asp Ala Leu Gly Lys Lys Gln Glu Ser
150 155 160 165
gag gat ctc atc caa ggc ttt aat gac aag tgc gaa gag atc aag tcc 643
Glu Asp Leu Ile Gln Gly Phe Asn Asp Lys Cys Glu Glu Ile Lys Ser
170 175 180
gag cat gat gtc gaa ggt aag acc gtc aac atg att cgt ccc cgc gac 691
Glu His Asp Val Glu Gly Lys Thr Val Asn Met Ile Arg Pro Arg Asp
185 190 195
gag caa acc atg agc cta tac ggc ccg acc tca ttt gcc ggc agc tct 739
Glu Gln Thr Met Ser Leu Tyr Gly Pro Thr Ser Phe Ala Gly Ser Ser
200 205 210
ttg gag tgc gca gga ctc acc att cct gat cag gaa tgg aag gat gac 787
Leu Glu Cys Ala Gly Leu Thr Ile Pro Asp Gln Glu Trp Lys Asp Asp
215 220 225
ctc cag gcc gac atc gct cct gag aac ttc atg ctc gcc acc gcc gac 835
Leu Gln Ala Asp Ile Ala Pro Glu Asn Phe Met Leu Ala Thr Ala Asp
230 235 240 245
tac gtc ttt gtc acc gca act gat gtc acc gat gaa aat gag ctc ccc 883
Tyr Val Phe Val Thr Ala Thr Asp Val Thr Asp Glu Asn Glu Leu Pro
250 255 260
gaa gta atc cga gaa aac cgc gaa cag ttc cca tca ctc acc ctt gtc 931
Glu Val Ile Arg Glu Asn Arg Glu Gln Phe Pro Ser Leu Thr Leu Val
265 270 275
gat acc agc tac tgg gta tct ggc gtc ggt cca ctt ggc ggc agc aaa 979
Asp Thr Ser Tyr Trp Val Ser Gly Val Gly Pro Leu Gly Gly Ser Lys
280 285 290
gtc ttg gaa gac atc gat gcc ttc ctc gac gca cag caa taatgtccac 1028
Val Leu Glu Asp Ile Asp Ala Phe Leu Asp Ala Gln Gln
295 300 305
agctctcccc gat 1041
<210> 572
<211> 306
<212> PRT
<213> Corynebacterium glutamicum
<400> 572
Met Ser Ser Arg Arg Lys Leu Ser Ser Ala Leu Ile Val Leu Leu Ala
1 5 10 15
Ala Ala Leu Pro Leu Thr Ala Cys Ser Ser Ser Ser Glu Glu Glu Ala
20 25 30
Ser Thr Ser Ser Ala Thr Arg Glu Phe Thr Asp Ala His Gly Thr Thr
35 40 45
Glu Val Pro Glu Asn Pro Gln Arg Val Val Val Leu Glu Pro Leu Glu
50 55 60
Leu Asp Thr Ala Ile Ala Leu Gly Ile Thr Pro Val Gly Ala Ala Val
65 70 75 80
Ala Asn Asn Val Thr Gly Ile Pro Ala Tyr Leu Gly Val Asp Gly Ile
85 90 95
Glu Pro Val Gly Thr Val Ser Glu Pro Asn Ile Glu Ala Ile Ala Ala
100 105 110
Leu Glu Pro Asp Leu Ile Leu Gly Thr Asp Ser Arg His Ala Glu Ile
115 120 125
Tyr Asp Arg Leu Glu Ser Ile Ala Pro Thr Val Phe Met Thr Thr His
130 135 140
Val Asp Pro Trp Lys Asp Asn Val Val Phe Ile Gly Asp Ala Leu Gly
145 150 155 160
Lys Lys Gln Glu Ser Glu Asp Leu Ile Gln Gly Phe Asn Asp Lys Cys
165 170 175
Glu Glu Ile Lys Ser Glu His Asp Val Glu Gly Lys Thr Val Asn Met
180 185 190
Ile Arg Pro Arg Asp Glu Gln Thr Met Ser Leu Tyr Gly Pro Thr Ser
195 200 205
Phe Ala Gly Ser Ser Leu Glu Cys Ala Gly Leu Thr Ile Pro Asp Gln
210 215 220
Glu Trp Lys Asp Asp Leu Gln Ala Asp Ile Ala Pro Glu Asn Phe Met
225 230 235 240
Leu Ala Thr Ala Asp Tyr Val Phe Val Thr Ala Thr Asp Val Thr Asp
245 250 255
Glu Asn Glu Leu Pro Glu Val Ile Arg Glu Asn Arg Glu Gln Phe Pro
260 265 270
Ser Leu Thr Leu Val Asp Thr Ser Tyr Trp Val Ser Gly Val Gly Pro
275 280 285
Leu Gly Gly Ser Lys Val Leu Glu Asp Ile Asp Ala Phe Leu Asp Ala
290 295 300
Gln Gln
305
<210> 573
<211> 440
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(417)
<223> RXN03183
<400> 573
gaa gcc gaa gca acc gca ggc aaa ttc gaa gta cag ccc ctc gta ggt 48
Glu Ala Glu Ala Thr Ala Gly Lys Phe Glu Val Gln Pro Leu Val Gly
1 5 10 15
aaa gac ggc gtc ggc gta tcc acc ctt ggt ggc tac aac aac ggc atc 96
Lys Asp Gly Val Gly Val Ser Thr Leu Gly Gly Tyr Asn Asn Gly Ile
20 25 30
aac gtc aac tcc gaa aac aag gca acc gcc cgc gac ttc atc gaa ttc 144
Asn Val Asn Ser Glu Asn Lys Ala Thr Ala Arg Asp Phe Ile Glu Phe
35 40 45
atc atc aac gaa gag aac caa acc tgg ttc gcg gac aac tcc ttc cca 192
Ile Ile Asn Glu Glu Asn Gln Thr Trp Phe Ala Asp Asn Ser Phe Pro
50 55 60
cca gtt ctg gca tcc atc tac gat gat gag tcc ctt gtt gag cag tac 240
Pro Val Leu Ala Ser Ile Tyr Asp Asp Glu Ser Leu Val Glu Gln Tyr
65 70 75 80
cca tac ctg cca gca ctg aag gaa tcc ctg gaa aac gca gca cca cgc 288
Pro Tyr Leu Pro Ala Leu Lys Glu Ser Leu Glu Asn Ala Ala Pro Arg
85 90 95
cca gtg tct cct ttc tac cca gcc atc tcc aag gca atc cag gac aac 336
Pro Val Ser Pro Phe Tyr Pro Ala Ile Ser Lys Ala Ile Gln Asp Asn
100 105 110
gcc tac gca gcg ctt aac ggc aac gtc gac gtt gac cag gca acc acc 384
Ala Tyr Ala Ala Leu Asn Gly Asn Val Asp Val Asp Gln Ala Thr Thr
115 120 125
gat atg aag gca gcg atc gaa aac gct tcc agc tagttcggta atttagttca 437
Asp Met Lys Ala Ala Ile Glu Asn Ala Ser Ser
130 135
ttc 440
<210> 574
<211> 139
<212> PRT
<213> Corynebacterium glutamicum
<400> 574
Glu Ala Glu Ala Thr Ala Gly Lys Phe Glu Val Gln Pro Leu Val Gly
1 5 10 15
Lys Asp Gly Val Gly Val Ser Thr Leu Gly Gly Tyr Asn Asn Gly Ile
20 25 30
Asn Val Asn Ser Glu Asn Lys Ala Thr Ala Arg Asp Phe Ile Glu Phe
35 40 45
Ile Ile Asn Glu Glu Asn Gln Thr Trp Phe Ala Asp Asn Ser Phe Pro
50 55 60
Pro Val Leu Ala Ser Ile Tyr Asp Asp Glu Ser Leu Val Glu Gln Tyr
65 70 75 80
Pro Tyr Leu Pro Ala Leu Lys Glu Ser Leu Glu Asn Ala Ala Pro Arg
85 90 95
Pro Val Ser Pro Phe Tyr Pro Ala Ile Ser Lys Ala Ile Gln Asp Asn
100 105 110
Ala Tyr Ala Ala Leu Asn Gly Asn Val Asp Val Asp Gln Ala Thr Thr
115 120 125
Asp Met Lys Ala Ala Ile Glu Asn Ala Ser Ser
130 135
<210> 575
<211> 1077
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1054)
<223> RXN01139
<400> 575
accaccgtgg caggcttttt cagtggcaag aagattaatt ctccacccct tcattttcaa 60
taagctttca ataaggggag aagtgtgctt agctggggtc atg gaa agc cac gat 115
Met Glu Ser His Asp
1 5
ctt cag cag cgc agt tat gcg cac aat ccc gat ggc cac gac cac agc 163
Leu Gln Gln Arg Ser Tyr Ala His Asn Pro Asp Gly His Asp His Ser
10 15 20
cat gac gga ctc gga cac tca cat gct ccc agc tcc ctc aag gct ctt 211
His Asp Gly Leu Gly His Ser His Ala Pro Ser Ser Leu Lys Ala Leu
25 30 35
ttt gcg gtc atc att ttc acc tcg atc atc ttc cta gcg gaa cta atc 259
Phe Ala Val Ile Ile Phe Thr Ser Ile Ile Phe Leu Ala Glu Leu Ile
40 45 50
gcc ggc ctt att tcc gga tct ttg gca ctg ctg gct gac gcc atg cac 307
Ala Gly Leu Ile Ser Gly Ser Leu Ala Leu Leu Ala Asp Ala Met His
55 60 65
atg ctg tcc gac tcc act ggc ttg atc att gcg gct gtc gcc atg ctc 355
Met Leu Ser Asp Ser Thr Gly Leu Ile Ile Ala Ala Val Ala Met Leu
70 75 80 85
att ggc cgt cgg gca cgc act tct cgt gcg acc tac gga tac aag cgt 403
Ile Gly Arg Arg Ala Arg Thr Ser Arg Ala Thr Tyr Gly Tyr Lys Arg
90 95 100
gcg gaa gtc ttg gca gcg atg gtt aac gcc acc gtt gtt aca gca ctg 451
Ala Glu Val Leu Ala Ala Met Val Asn Ala Thr Val Val Thr Ala Leu
105 110 115
tct gtg tgg atc gtc gtt gag gcc atc atg cgt ctg ggc aag gac ctg 499
Ser Val Trp Ile Val Val Glu Ala Ile Met Arg Leu Gly Lys Asp Leu
120 125 130
gaa atc cag acc aac ctg atg ctc atc gtc gcg gtc att ggt ttt gtc 547
Glu Ile Gln Thr Asn Leu Met Leu Ile Val Ala Val Ile Gly Phe Val
135 140 145
acc aac gga att tcc gcc ctg gtg ttg atg cgc cac caa gat ggc aat 595
Thr Asn Gly Ile Ser Ala Leu Val Leu Met Arg His Gln Asp Gly Asn
150 155 160 165
atc aat atg cgt gga gca ttc ctt cac gtt ctc agt gac atg ctg ggt 643
Ile Asn Met Arg Gly Ala Phe Leu His Val Leu Ser Asp Met Leu Gly
170 175 180
tcc gtt gcc gtc att att gcg ggc ctg gtg att cgc tac acg gga tgg 691
Ser Val Ala Val Ile Ile Ala Gly Leu Val Ile Arg Tyr Thr Gly Trp
185 190 195
atg ccg gcc gat acc att gct tcg att gcg att gct gcg att att att 739
Met Pro Ala Asp Thr Ile Ala Ser Ile Ala Ile Ala Ala Ile Ile Ile
200 205 210
cct cgc gca ttc agc ctc ctg aag gaa gct ctc aat atc ttg ttg gag 787
Pro Arg Ala Phe Ser Leu Leu Lys Glu Ala Leu Asn Ile Leu Leu Glu
215 220 225
cgt gtt cct aca ggt gcg gag cct gca gag gtc gac gca gcc ctt cgt 835
Arg Val Pro Thr Gly Ala Glu Pro Ala Glu Val Asp Ala Ala Leu Arg
230 235 240 245
aaa gtc cca ggt gtc agc gat gtg cat gat ctt cac att tgg agc att 883
Lys Val Pro Gly Val Ser Asp Val His Asp Leu His Ile Trp Ser Ile
250 255 260
gac ggc aag gaa atc ctg gcc acg gtg cat ttg gtg gtg gat tcg tct 931
Asp Gly Lys Glu Ile Leu Ala Thr Val His Leu Val Val Asp Ser Ser
265 270 275
aca aat cag ctg cat agt tgt ggc gtg ttg gat cgg gca gaa gcg gaa 979
Thr Asn Gln Leu His Ser Cys Gly Val Leu Asp Arg Ala Glu Ala Glu
280 285 290
cta tcc aaa ctt ggg atc ttg cac tca aca att cag ctg gaa agc gca 1027
Leu Ser Lys Leu Gly Ile Leu His Ser Thr Ile Gln Leu Glu Ser Ala
295 300 305
gat cac agt gat cat gaa agt gtg tgc tgatatagag tatgtcccat 1074
Asp His Ser Asp His Glu Ser Val Cys
310 315
ggg 1077
<210> 576
<211> 318
<212> PRT
<213> Corynebacterium glutamicum
<400> 576
Met Glu Ser His Asp Leu Gln Gln Arg Ser Tyr Ala His Asn Pro Asp
1 5 10 15
Gly His Asp His Ser His Asp Gly Leu Gly His Ser His Ala Pro Ser
20 25 30
Ser Leu Lys Ala Leu Phe Ala Val Ile Ile Phe Thr Ser Ile Ile Phe
35 40 45
Leu Ala Glu Leu Ile Ala Gly Leu Ile Ser Gly Ser Leu Ala Leu Leu
50 55 60
Ala Asp Ala Met His Met Leu Ser Asp Ser Thr Gly Leu Ile Ile Ala
65 70 75 80
Ala Val Ala Met Leu Ile Gly Arg Arg Ala Arg Thr Ser Arg Ala Thr
85 90 95
Tyr Gly Tyr Lys Arg Ala Glu Val Leu Ala Ala Met Val Asn Ala Thr
100 105 110
Val Val Thr Ala Leu Ser Val Trp Ile Val Val Glu Ala Ile Met Arg
115 120 125
Leu Gly Lys Asp Leu Glu Ile Gln Thr Asn Leu Met Leu Ile Val Ala
130 135 140
Val Ile Gly Phe Val Thr Asn Gly Ile Ser Ala Leu Val Leu Met Arg
145 150 155 160
His Gln Asp Gly Asn Ile Asn Met Arg Gly Ala Phe Leu His Val Leu
165 170 175
Ser Asp Met Leu Gly Ser Val Ala Val Ile Ile Ala Gly Leu Val Ile
180 185 190
Arg Tyr Thr Gly Trp Met Pro Ala Asp Thr Ile Ala Ser Ile Ala Ile
195 200 205
Ala Ala Ile Ile Ile Pro Arg Ala Phe Ser Leu Leu Lys Glu Ala Leu
210 215 220
Asn Ile Leu Leu Glu Arg Val Pro Thr Gly Ala Glu Pro Ala Glu Val
225 230 235 240
Asp Ala Ala Leu Arg Lys Val Pro Gly Val Ser Asp Val His Asp Leu
245 250 255
His Ile Trp Ser Ile Asp Gly Lys Glu Ile Leu Ala Thr Val His Leu
260 265 270
Val Val Asp Ser Ser Thr Asn Gln Leu His Ser Cys Gly Val Leu Asp
275 280 285
Arg Ala Glu Ala Glu Leu Ser Lys Leu Gly Ile Leu His Ser Thr Ile
290 295 300
Gln Leu Glu Ser Ala Asp His Ser Asp His Glu Ser Val Cys
305 310 315
<210> 577
<211> 2733
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(2710)
<223> RXN00378
<400> 577
accgtgagcc ttatactgtg aggacattaa aagtgacacc tctttttcta tcttttacaa 60
cccaagaagg tttatcgtga gcacaccgga ttcttcctcg gtg gac aag gcc gta 115
Val Asp Lys Ala Val
1 5
aac act gct atc tct gac gcc aaa aca gcg gcg ctc aag gca ggt gtt 163
Asn Thr Ala Ile Ser Asp Ala Lys Thr Ala Ala Leu Lys Ala Gly Val
10 15 20
gga ttg aac cga gcc acc gcc tca gaa gaa gag gaa gat tta agc tca 211
Gly Leu Asn Arg Ala Thr Ala Ser Glu Glu Glu Glu Asp Leu Ser Ser
25 30 35
agc att aag gtt tct ttg gcc ttt gag ctc gag ggg tta agc aat gca 259
Ser Ile Lys Val Ser Leu Ala Phe Glu Leu Glu Gly Leu Ser Asn Ala
40 45 50
cca tcg ttg atg gtg gtg gaa aaa gcc cta gag aag atc ccc ggt gta 307
Pro Ser Leu Met Val Val Glu Lys Ala Leu Glu Lys Ile Pro Gly Val
55 60 65
tcc gcg gat ctg att tac cct tca caa act gca tgg att aca gca act 355
Ser Ala Asp Leu Ile Tyr Pro Ser Gln Thr Ala Trp Ile Thr Ala Thr
70 75 80 85
gat cgg gta cat ccc gaa acc ctc att gag gtg ttt gag cag ttc ggc 403
Asp Arg Val His Pro Glu Thr Leu Ile Glu Val Phe Glu Gln Phe Gly
90 95 100
atc aaa gca cac ctt tct aat tca tcg ctg ctg cgc agg cat caa cag 451
Ile Lys Ala His Leu Ser Asn Ser Ser Leu Leu Arg Arg His Gln Gln
105 110 115
ctc agc gcg gaa gta aat agg gaa gca cgc ctt gat cgt tac cgc tcc 499
Leu Ser Ala Glu Val Asn Arg Glu Ala Arg Leu Asp Arg Tyr Arg Ser
120 125 130
cga atg gat gcc aag cga atc tcg cct cgt gtg cga agg cat aac cga 547
Arg Met Asp Ala Lys Arg Ile Ser Pro Arg Val Arg Arg His Asn Arg
135 140 145
caa gaa atg gta cat gcg gta cgc gct cgt gaa agt ggt tgg att aaa 595
Gln Glu Met Val His Ala Val Arg Ala Arg Glu Ser Gly Trp Ile Lys
150 155 160 165
cgc agg aat cac acc acc tcg cag cat gaa gac cca atg tcg ggc gat 643
Arg Arg Asn His Thr Thr Ser Gln His Glu Asp Pro Met Ser Gly Asp
170 175 180
gtg ctg ttc acc gcc cgc gca ctg att aca cct aag cgt ttg tgg gtg 691
Val Leu Phe Thr Ala Arg Ala Leu Ile Thr Pro Lys Arg Leu Trp Val
185 190 195
tcg ttg ccg ttt gcg ctc atc gta ttg gcg tta tcg ttg aat cct tcg 739
Ser Leu Pro Phe Ala Leu Ile Val Leu Ala Leu Ser Leu Asn Pro Ser
200 205 210
tgg cag ttt gat tat tgg cag tgg ttg tcc gct gtg ttg gct att cct 787
Trp Gln Phe Asp Tyr Trp Gln Trp Leu Ser Ala Val Leu Ala Ile Pro
215 220 225
gtg gtg gtg tgg ggt gcc tgg ccg ttt cac cgc gct gca gca ggc ggt 835
Val Val Val Trp Gly Ala Trp Pro Phe His Arg Ala Ala Ala Gly Gly
230 235 240 245
att cgt cga gga att tcc gct ctt gat gcg acc agc tca atc gct att 883
Ile Arg Arg Gly Ile Ser Ala Leu Asp Ala Thr Ser Ser Ile Ala Ile
250 255 260
gct gct gca tac gcg tgg tct atc gcc atg ctg ttg ttt gaa acc cca 931
Ala Ala Ala Tyr Ala Trp Ser Ile Ala Met Leu Leu Phe Glu Thr Pro
265 270 275
gga ggt aaa tcc tgg cgg tca tat ccg tcc tgg ttc gct ttt gac cac 979
Gly Gly Lys Ser Trp Arg Ser Tyr Pro Ser Trp Phe Ala Phe Asp His
280 285 290
ggc acg ttg acc caa aac gag att tat ttt gat gtg gcc tgc gga atc 1027
Gly Thr Leu Thr Gln Asn Glu Ile Tyr Phe Asp Val Ala Cys Gly Ile
295 300 305
acc gtg ttg ctt ctt gcc gga cgg ctg ctg aca agg cgt cga agc caa 1075
Thr Val Leu Leu Leu Ala Gly Arg Leu Leu Thr Arg Arg Arg Ser Gln
310 315 320 325
tcc agt ttg tta gcg gaa ctt ggt cgc ctc caa atc gat cca cag cgc 1123
Ser Ser Leu Leu Ala Glu Leu Gly Arg Leu Gln Ile Asp Pro Gln Arg
330 335 340
att gtc act gtg gtg cgt aaa cac cga ttg aag cgc gta gtc cag gaa 1171
Ile Val Thr Val Val Arg Lys His Arg Leu Lys Arg Val Val Gln Glu
345 350 355
ctg aac att cca gtg cag gaa gtc cgt gtc aat gac gat gtg aaa gtt 1219
Leu Asn Ile Pro Val Gln Glu Val Arg Val Asn Asp Asp Val Lys Val
360 365 370
cca cct aat acc acg atc cct gtg gat ggc act gtc atc ggt ggc ggt 1267
Pro Pro Asn Thr Thr Ile Pro Val Asp Gly Thr Val Ile Gly Gly Gly
375 380 385
tcg cgg atc gca gct agc atc atc atg gga caa gac cag cgt gat gta 1315
Ser Arg Ile Ala Ala Ser Ile Ile Met Gly Gln Asp Gln Arg Asp Val
390 395 400 405
aaa gta aat gac aaa gtt ttc gcc ggc agc ctc aac ctc gaa tcc gaa 1363
Lys Val Asn Asp Lys Val Phe Ala Gly Ser Leu Asn Leu Glu Ser Glu
410 415 420
atc aag gtt cgt gtt att cgc act ggt cac cgc acc cgc atc gcc gcg 1411
Ile Lys Val Arg Val Ile Arg Thr Gly His Arg Thr Arg Ile Ala Ala
425 430 435
gta cat agg tgg gtt aaa gaa gcg acg ttg aag gaa aac cgc cac aat 1459
Val His Arg Trp Val Lys Glu Ala Thr Leu Lys Glu Asn Arg His Asn
440 445 450
agg gca gcg atc cgt tcg gcc ggt aac ctt gtg ccc atc acg ttc acc 1507
Arg Ala Ala Ile Arg Ser Ala Gly Asn Leu Val Pro Ile Thr Phe Thr
455 460 465
ctt gct gtg gtg gac ttc tgt ctg tgg gca ctg atc tct gga aac atc 1555
Leu Ala Val Val Asp Phe Cys Leu Trp Ala Leu Ile Ser Gly Asn Ile
470 475 480 485
aac gct gca ttt acc act acc ttg gct gtc ctt gcg tgc gtg gct ccg 1603
Asn Ala Ala Phe Thr Thr Thr Leu Ala Val Leu Ala Cys Val Ala Pro
490 495 500
gtg gcc tta gcg ttg tct gct cca ctt gcc acg agg aat tcc atc gaa 1651
Val Ala Leu Ala Leu Ser Ala Pro Leu Ala Thr Arg Asn Ser Ile Glu
505 510 515
gct gca gca cga cac ggt att ttg gtc cgc tct ggt gaa att ttc cga 1699
Ala Ala Ala Arg His Gly Ile Leu Val Arg Ser Gly Glu Ile Phe Arg
520 525 530
gtt ctc gat gat gtg gat act gcc gta ttt aat cgt gtg ggc aca cta 1747
Val Leu Asp Asp Val Asp Thr Ala Val Phe Asn Arg Val Gly Thr Leu
535 540 545
acc gat ggc gaa atg aca gtg gaa acc gtc aca gca gac aaa ggc gag 1795
Thr Asp Gly Glu Met Thr Val Glu Thr Val Thr Ala Asp Lys Gly Glu
550 555 560 565
gac cca gaa cta gtg ctg cgt gtc gcc ggg gcg ttg gcc atg gaa tcc 1843
Asp Pro Glu Leu Val Leu Arg Val Ala Gly Ala Leu Ala Met Glu Ser
570 575 580
cac cac gcg att tcc aaa gca ctg gtg aaa gca tcc cgt gaa gct cgt 1891
His His Ala Ile Ser Lys Ala Leu Val Lys Ala Ser Arg Glu Ala Arg
585 590 595
gat acc ggc gcc ggt ggt gaa gat gtc cca cac tgg att gaa gta ggc 1939
Asp Thr Gly Ala Gly Gly Glu Asp Val Pro His Trp Ile Glu Val Gly
600 605 610
aac gtg gaa atc acc gaa gcc ggc tca ttc caa gca acc atc gag ctg 1987
Asn Val Glu Ile Thr Glu Ala Gly Ser Phe Gln Ala Thr Ile Glu Leu
615 620 625
cca ctg atc aaa cca tct ggc gaa aaa atc atg cgc acc aca gaa gca 2035
Pro Leu Ile Lys Pro Ser Gly Glu Lys Ile Met Arg Thr Thr Glu Ala
630 635 640 645
ctc ctg tgg cga cca cga tcc atg aca gaa gtc cgt gag cac tta agc 2083
Leu Leu Trp Arg Pro Arg Ser Met Thr Glu Val Arg Glu His Leu Ser
650 655 660
ccc cga cta gtg gca gca gca acc tca ggt ggc gca cca ctg atc gtg 2131
Pro Arg Leu Val Ala Ala Ala Thr Ser Gly Gly Ala Pro Leu Ile Val
665 670 675
cga tgg aaa ggc aaa gac cgc gga gtt atc act cta agt gac cac gtg 2179
Arg Trp Lys Gly Lys Asp Arg Gly Val Ile Thr Leu Ser Asp His Val
680 685 690
aga tca gat tcc tcc gat gcg att att gcg att gaa gaa caa ggc atc 2227
Arg Ser Asp Ser Ser Asp Ala Ile Ile Ala Ile Glu Glu Gln Gly Ile
695 700 705
gag acc atg atg ctt tca cgt gat act tac ccg gtg gca cgt cga tac 2275
Glu Thr Met Met Leu Ser Arg Asp Thr Tyr Pro Val Ala Arg Arg Tyr
710 715 720 725
gca gac agc tta ggc atc acc cac gtc ttg gcc ggc atc gcg ccg ggc 2323
Ala Asp Ser Leu Gly Ile Thr His Val Leu Ala Gly Ile Ala Pro Gly
730 735 740
aag aaa gcc cag gtc gtc cgt gca gtc cac acc cgc gga tcc act gtc 2371
Lys Lys Ala Gln Val Val Arg Ala Val His Thr Arg Gly Ser Thr Val
745 750 755
gcg atg atc ggc gat gaa tca gta atg gac tgt ttg aaa gtc gct gac 2419
Ala Met Ile Gly Asp Glu Ser Val Met Asp Cys Leu Lys Val Ala Asp
760 765 770
gtg ggt gta ctg atg ggc gtc gat cgt ccc tca gat ctg cgt gat gat 2467
Val Gly Val Leu Met Gly Val Asp Arg Pro Ser Asp Leu Arg Asp Asp
775 780 785
tcc gat gac ccg gca gct gac gtt gtg gtc atg cgc gaa gag gtc atg 2515
Ser Asp Asp Pro Ala Ala Asp Val Val Val Met Arg Glu Glu Val Met
790 795 800 805
agc gtg ccg acg ctg ttt aaa ctg gct cga cgc tac gcc aag ttg gtc 2563
Ser Val Pro Thr Leu Phe Lys Leu Ala Arg Arg Tyr Ala Lys Leu Val
810 815 820
aat ggc aat att gct ctg gcc tgg atc tat aac ggt gtt gcc atg gtg 2611
Asn Gly Asn Ile Ala Leu Ala Trp Ile Tyr Asn Gly Val Ala Met Val
825 830 835
ctt gca gtg tct ggc ttg ctg cat cca atg gct gcg acc gtg gct atg 2659
Leu Ala Val Ser Gly Leu Leu His Pro Met Ala Ala Thr Val Ala Met
840 845 850
ctg gcg tct tcg ctg ctt att gaa tgg cgc tcg ggc agg gcg cgc aag 2707
Leu Ala Ser Ser Leu Leu Ile Glu Trp Arg Ser Gly Arg Ala Arg Lys
855 860 865
tac taaccagcaa ttcccaagcc caa 2733
Tyr
870
<210> 578
<211> 870
<212> PRT
<213> Corynebacterium glutamicum
<400> 578
Val Asp Lys Ala Val Asn Thr Ala Ile Ser Asp Ala Lys Thr Ala Ala
1 5 10 15
Leu Lys Ala Gly Val Gly Leu Asn Arg Ala Thr Ala Ser Glu Glu Glu
20 25 30
Glu Asp Leu Ser Ser Ser Ile Lys Val Ser Leu Ala Phe Glu Leu Glu
35 40 45
Gly Leu Ser Asn Ala Pro Ser Leu Met Val Val Glu Lys Ala Leu Glu
50 55 60
Lys Ile Pro Gly Val Ser Ala Asp Leu Ile Tyr Pro Ser Gln Thr Ala
65 70 75 80
Trp Ile Thr Ala Thr Asp Arg Val His Pro Glu Thr Leu Ile Glu Val
85 90 95
Phe Glu Gln Phe Gly Ile Lys Ala His Leu Ser Asn Ser Ser Leu Leu
100 105 110
Arg Arg His Gln Gln Leu Ser Ala Glu Val Asn Arg Glu Ala Arg Leu
115 120 125
Asp Arg Tyr Arg Ser Arg Met Asp Ala Lys Arg Ile Ser Pro Arg Val
130 135 140
Arg Arg His Asn Arg Gln Glu Met Val His Ala Val Arg Ala Arg Glu
145 150 155 160
Ser Gly Trp Ile Lys Arg Arg Asn His Thr Thr Ser Gln His Glu Asp
165 170 175
Pro Met Ser Gly Asp Val Leu Phe Thr Ala Arg Ala Leu Ile Thr Pro
180 185 190
Lys Arg Leu Trp Val Ser Leu Pro Phe Ala Leu Ile Val Leu Ala Leu
195 200 205
Ser Leu Asn Pro Ser Trp Gln Phe Asp Tyr Trp Gln Trp Leu Ser Ala
210 215 220
Val Leu Ala Ile Pro Val Val Val Trp Gly Ala Trp Pro Phe His Arg
225 230 235 240
Ala Ala Ala Gly Gly Ile Arg Arg Gly Ile Ser Ala Leu Asp Ala Thr
245 250 255
Ser Ser Ile Ala Ile Ala Ala Ala Tyr Ala Trp Ser Ile Ala Met Leu
260 265 270
Leu Phe Glu Thr Pro Gly Gly Lys Ser Trp Arg Ser Tyr Pro Ser Trp
275 280 285
Phe Ala Phe Asp His Gly Thr Leu Thr Gln Asn Glu Ile Tyr Phe Asp
290 295 300
Val Ala Cys Gly Ile Thr Val Leu Leu Leu Ala Gly Arg Leu Leu Thr
305 310 315 320
Arg Arg Arg Ser Gln Ser Ser Leu Leu Ala Glu Leu Gly Arg Leu Gln
325 330 335
Ile Asp Pro Gln Arg Ile Val Thr Val Val Arg Lys His Arg Leu Lys
340 345 350
Arg Val Val Gln Glu Leu Asn Ile Pro Val Gln Glu Val Arg Val Asn
355 360 365
Asp Asp Val Lys Val Pro Pro Asn Thr Thr Ile Pro Val Asp Gly Thr
370 375 380
Val Ile Gly Gly Gly Ser Arg Ile Ala Ala Ser Ile Ile Met Gly Gln
385 390 395 400
Asp Gln Arg Asp Val Lys Val Asn Asp Lys Val Phe Ala Gly Ser Leu
405 410 415
Asn Leu Glu Ser Glu Ile Lys Val Arg Val Ile Arg Thr Gly His Arg
420 425 430
Thr Arg Ile Ala Ala Val His Arg Trp Val Lys Glu Ala Thr Leu Lys
435 440 445
Glu Asn Arg His Asn Arg Ala Ala Ile Arg Ser Ala Gly Asn Leu Val
450 455 460
Pro Ile Thr Phe Thr Leu Ala Val Val Asp Phe Cys Leu Trp Ala Leu
465 470 475 480
Ile Ser Gly Asn Ile Asn Ala Ala Phe Thr Thr Thr Leu Ala Val Leu
485 490 495
Ala Cys Val Ala Pro Val Ala Leu Ala Leu Ser Ala Pro Leu Ala Thr
500 505 510
Arg Asn Ser Ile Glu Ala Ala Ala Arg His Gly Ile Leu Val Arg Ser
515 520 525
Gly Glu Ile Phe Arg Val Leu Asp Asp Val Asp Thr Ala Val Phe Asn
530 535 540
Arg Val Gly Thr Leu Thr Asp Gly Glu Met Thr Val Glu Thr Val Thr
545 550 555 560
Ala Asp Lys Gly Glu Asp Pro Glu Leu Val Leu Arg Val Ala Gly Ala
565 570 575
Leu Ala Met Glu Ser His His Ala Ile Ser Lys Ala Leu Val Lys Ala
580 585 590
Ser Arg Glu Ala Arg Asp Thr Gly Ala Gly Gly Glu Asp Val Pro His
595 600 605
Trp Ile Glu Val Gly Asn Val Glu Ile Thr Glu Ala Gly Ser Phe Gln
610 615 620
Ala Thr Ile Glu Leu Pro Leu Ile Lys Pro Ser Gly Glu Lys Ile Met
625 630 635 640
Arg Thr Thr Glu Ala Leu Leu Trp Arg Pro Arg Ser Met Thr Glu Val
645 650 655
Arg Glu His Leu Ser Pro Arg Leu Val Ala Ala Ala Thr Ser Gly Gly
660 665 670
Ala Pro Leu Ile Val Arg Trp Lys Gly Lys Asp Arg Gly Val Ile Thr
675 680 685
Leu Ser Asp His Val Arg Ser Asp Ser Ser Asp Ala Ile Ile Ala Ile
690 695 700
Glu Glu Gln Gly Ile Glu Thr Met Met Leu Ser Arg Asp Thr Tyr Pro
705 710 715 720
Val Ala Arg Arg Tyr Ala Asp Ser Leu Gly Ile Thr His Val Leu Ala
725 730 735
Gly Ile Ala Pro Gly Lys Lys Ala Gln Val Val Arg Ala Val His Thr
740 745 750
Arg Gly Ser Thr Val Ala Met Ile Gly Asp Glu Ser Val Met Asp Cys
755 760 765
Leu Lys Val Ala Asp Val Gly Val Leu Met Gly Val Asp Arg Pro Ser
770 775 780
Asp Leu Arg Asp Asp Ser Asp Asp Pro Ala Ala Asp Val Val Val Met
785 790 795 800
Arg Glu Glu Val Met Ser Val Pro Thr Leu Phe Lys Leu Ala Arg Arg
805 810 815
Tyr Ala Lys Leu Val Asn Gly Asn Ile Ala Leu Ala Trp Ile Tyr Asn
820 825 830
Gly Val Ala Met Val Leu Ala Val Ser Gly Leu Leu His Pro Met Ala
835 840 845
Ala Thr Val Ala Met Leu Ala Ser Ser Leu Leu Ile Glu Trp Arg Ser
850 855 860
Gly Arg Ala Arg Lys Tyr
865 870
<210> 579
<211> 1925
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(1902)
<223> RXN01338
<400> 579
aaa act tat acc cca aat ccc tgg atg tta ttc atc cgc tca ttt gat 48
Lys Thr Tyr Thr Pro Asn Pro Trp Met Leu Phe Ile Arg Ser Phe Asp
1 5 10 15
ggc atc atc act gtc gca gcc ctt gtt gcc atc gca ata cat ctc att 96
Gly Ile Ile Thr Val Ala Ala Leu Val Ala Ile Ala Ile His Leu Ile
20 25 30
tta tgg ctg gct cta gat cta gat ggc ctt gct aaa aac tgg cct tta 144
Leu Trp Leu Ala Leu Asp Leu Asp Gly Leu Ala Lys Asn Trp Pro Leu
35 40 45
ata gcc atc gtt atc gta ggt ggc att ccg ttg atg tgg gat gtg ctg 192
Ile Ala Ile Val Ile Val Gly Gly Ile Pro Leu Met Trp Asp Val Leu
50 55 60
aaa tca gcc att aaa act cgc ggt ggc gcg gat act tta gca gca gtc 240
Lys Ser Ala Ile Lys Thr Arg Gly Gly Ala Asp Thr Leu Ala Ala Val
65 70 75 80
tcc atc att act tct gtg ttg tta ggg gag tgg ttg gtt gcc gcg atc 288
Ser Ile Ile Thr Ser Val Leu Leu Gly Glu Trp Leu Val Ala Ala Ile
85 90 95
atc gtg ctc atg ctc tct ggt ggt gaa gcg cta gaa gag gca gca tca 336
Ile Val Leu Met Leu Ser Gly Gly Glu Ala Leu Glu Glu Ala Ala Ser
100 105 110
cgg cga gcc agt ggc acc ttg gac gca ctt gcc cgg cgc gca cca agt 384
Arg Arg Ala Ser Gly Thr Leu Asp Ala Leu Ala Arg Arg Ala Pro Ser
115 120 125
aca gct cac cgc ctg ttg ggt gca acc att ctt gat gga acc gaa gag 432
Thr Ala His Arg Leu Leu Gly Ala Thr Ile Leu Asp Gly Thr Glu Glu
130 135 140
atc gcc gtg gaa gag atc acg gtt ggt gat tta gtg gcg gtg ctc ccg 480
Ile Ala Val Glu Glu Ile Thr Val Gly Asp Leu Val Ala Val Leu Pro
145 150 155 160
cat gaa ctt tgt ccc gtg gat ggt gaa atc gtg gca ggc cac ggc acc 528
His Glu Leu Cys Pro Val Asp Gly Glu Ile Val Ala Gly His Gly Thr
165 170 175
atg gat gag tct tat ctc acg ggt gag ccc tat gtg gtg agt aaa tct 576
Met Asp Glu Ser Tyr Leu Thr Gly Glu Pro Tyr Val Val Ser Lys Ser
180 185 190
aaa ggt tcg caa gca atg tcg ggt gca gtc aat ggt gat act ccg ctg 624
Lys Gly Ser Gln Ala Met Ser Gly Ala Val Asn Gly Asp Thr Pro Leu
195 200 205
acg att gtt gcc aca aag ctt gcc cat gat tcc aga tac gcc caa att 672
Thr Ile Val Ala Thr Lys Leu Ala His Asp Ser Arg Tyr Ala Gln Ile
210 215 220
gtt ggt gta ctc cat gaa gca gaa aac aac cgc cca gaa atg cgc agg 720
Val Gly Val Leu His Glu Ala Glu Asn Asn Arg Pro Glu Met Arg Arg
225 230 235 240
atg gct gac cgt ctt ggc gcg tgg tat acg gtg att gca ctt gcc ctc 768
Met Ala Asp Arg Leu Gly Ala Trp Tyr Thr Val Ile Ala Leu Ala Leu
245 250 255
ggt ggt ctt ggc tgg att gtc tcc ggc gac cca gtg agg ttc ttg gct 816
Gly Gly Leu Gly Trp Ile Val Ser Gly Asp Pro Val Arg Phe Leu Ala
260 265 270
gtt gtc gtt gtc gcc acc cca tgt cca ttg ctc att gca gtg cca gtg 864
Val Val Val Val Ala Thr Pro Cys Pro Leu Leu Ile Ala Val Pro Val
275 280 285
gcg atc atc ggt gcg att tct ctt gcg gct cgt cgg ggc atc atc gtg 912
Ala Ile Ile Gly Ala Ile Ser Leu Ala Ala Arg Arg Gly Ile Ile Val
290 295 300
aag aac cct gga atg ctg gaa aac gct tca gga gta aag aca gtg atg 960
Lys Asn Pro Gly Met Leu Glu Asn Ala Ser Gly Val Lys Thr Val Met
305 310 315 320
ttc gat aag act gga acg ctc acc tat ggc agg cca gtg att act gat 1008
Phe Asp Lys Thr Gly Thr Leu Thr Tyr Gly Arg Pro Val Ile Thr Asp
325 330 335
atc cac act gct ccc gga gtt gag gaa gat aca gtc cta gct ttg gct 1056
Ile His Thr Ala Pro Gly Val Glu Glu Asp Thr Val Leu Ala Leu Ala
340 345 350
gct tca gta gag cgc tac tcc aga cac ccg ttg gct gac gcg att cgt 1104
Ala Ser Val Glu Arg Tyr Ser Arg His Pro Leu Ala Asp Ala Ile Arg
355 360 365
gag ggc gca aaa gcc agg gaa ctt cat ctg cct gat gta gtg gaa gta 1152
Glu Gly Ala Lys Ala Arg Glu Leu His Leu Pro Asp Val Val Glu Val
370 375 380
tcg gaa cgt cca gga cag gga cta acc ggc acg gtg ggc gag cac ctg 1200
Ser Glu Arg Pro Gly Gln Gly Leu Thr Gly Thr Val Gly Glu His Leu
385 390 395 400
gtt cga ata acc aat agg cgc agc aca cta gaa att gat cca gac agc 1248
Val Arg Ile Thr Asn Arg Arg Ser Thr Leu Glu Ile Asp Pro Asp Ser
405 410 415
aag aac tac att ccg gtg aca agt tcc ggc atg gaa tct gtg gtg ctt 1296
Lys Asn Tyr Ile Pro Val Thr Ser Ser Gly Met Glu Ser Val Val Leu
420 425 430
gtt gat gat aaa tat gca gca ctc att cgc ctc cgg gat gaa cct cgt 1344
Val Asp Asp Lys Tyr Ala Ala Leu Ile Arg Leu Arg Asp Glu Pro Arg
435 440 445
gca tct gcc agt gag ttc atc gcg cac ttg ccc aag aag cac aaa gtg 1392
Ala Ser Ala Ser Glu Phe Ile Ala His Leu Pro Lys Lys His Lys Val
450 455 460
gac aag ctc atg att atc tct ggt gat cgc gca tct gag gtt cgt tac 1440
Asp Lys Leu Met Ile Ile Ser Gly Asp Arg Ala Ser Glu Val Arg Tyr
465 470 475 480
ctt gcg gac aag gtt ggc att gat gag gta cac gca gag gcc tca ccg 1488
Leu Ala Asp Lys Val Gly Ile Asp Glu Val His Ala Glu Ala Ser Pro
485 490 495
gaa gac aag ctg aac att gtt aat cgg cat aat gag cac ggc gcc acc 1536
Glu Asp Lys Leu Asn Ile Val Asn Arg His Asn Glu His Gly Ala Thr
500 505 510
atg ttc tta ggt gat gga atc aac gat gcg cca gcc atg gcc gtt gcc 1584
Met Phe Leu Gly Asp Gly Ile Asn Asp Ala Pro Ala Met Ala Val Ala
515 520 525
acc gtt ggt gtc gcg atg gga gca gac tcc gat gtc acg tcc gaa gca 1632
Thr Val Gly Val Ala Met Gly Ala Asp Ser Asp Val Thr Ser Glu Ala
530 535 540
gca gat gct gtg att ttg gat tct tcc ctg gaa cgt ctc gac gat ctg 1680
Ala Asp Ala Val Ile Leu Asp Ser Ser Leu Glu Arg Leu Asp Asp Leu
545 550 555 560
ctc cac atc agt gca cgg atg cgt cga ata gcg ttg caa tct gcg ggc 1728
Leu His Ile Ser Ala Arg Met Arg Arg Ile Ala Leu Gln Ser Ala Gly
565 570 575
ggt ggc atg gcg ttg agt gtc ata gga atg atc ctc gcg gta ttt gga 1776
Gly Gly Met Ala Leu Ser Val Ile Gly Met Ile Leu Ala Val Phe Gly
580 585 590
ttc ttg acg cca ctg atg ggt gcg atc ttc caa gag gtc att gac gtg 1824
Phe Leu Thr Pro Leu Met Gly Ala Ile Phe Gln Glu Val Ile Asp Val
595 600 605
ctg gct atc ctc aat tcc gct cgg gtc gca ctg cca cgc gga gcg att 1872
Leu Ala Ile Leu Asn Ser Ala Arg Val Ala Leu Pro Arg Gly Ala Ile
610 615 620
agt gat ttt gat acg caa gaa aaa gtt tct tagcagggta acctaaatgt 1922
Ser Asp Phe Asp Thr Gln Glu Lys Val Ser
625 630
cgt 1925
<210> 580
<211> 634
<212> PRT
<213> Corynebacterium glutamicum
<400> 580
Lys Thr Tyr Thr Pro Asn Pro Trp Met Leu Phe Ile Arg Ser Phe Asp
1 5 10 15
Gly Ile Ile Thr Val Ala Ala Leu Val Ala Ile Ala Ile His Leu Ile
20 25 30
Leu Trp Leu Ala Leu Asp Leu Asp Gly Leu Ala Lys Asn Trp Pro Leu
35 40 45
Ile Ala Ile Val Ile Val Gly Gly Ile Pro Leu Met Trp Asp Val Leu
50 55 60
Lys Ser Ala Ile Lys Thr Arg Gly Gly Ala Asp Thr Leu Ala Ala Val
65 70 75 80
Ser Ile Ile Thr Ser Val Leu Leu Gly Glu Trp Leu Val Ala Ala Ile
85 90 95
Ile Val Leu Met Leu Ser Gly Gly Glu Ala Leu Glu Glu Ala Ala Ser
100 105 110
Arg Arg Ala Ser Gly Thr Leu Asp Ala Leu Ala Arg Arg Ala Pro Ser
115 120 125
Thr Ala His Arg Leu Leu Gly Ala Thr Ile Leu Asp Gly Thr Glu Glu
130 135 140
Ile Ala Val Glu Glu Ile Thr Val Gly Asp Leu Val Ala Val Leu Pro
145 150 155 160
His Glu Leu Cys Pro Val Asp Gly Glu Ile Val Ala Gly His Gly Thr
165 170 175
Met Asp Glu Ser Tyr Leu Thr Gly Glu Pro Tyr Val Val Ser Lys Ser
180 185 190
Lys Gly Ser Gln Ala Met Ser Gly Ala Val Asn Gly Asp Thr Pro Leu
195 200 205
Thr Ile Val Ala Thr Lys Leu Ala His Asp Ser Arg Tyr Ala Gln Ile
210 215 220
Val Gly Val Leu His Glu Ala Glu Asn Asn Arg Pro Glu Met Arg Arg
225 230 235 240
Met Ala Asp Arg Leu Gly Ala Trp Tyr Thr Val Ile Ala Leu Ala Leu
245 250 255
Gly Gly Leu Gly Trp Ile Val Ser Gly Asp Pro Val Arg Phe Leu Ala
260 265 270
Val Val Val Val Ala Thr Pro Cys Pro Leu Leu Ile Ala Val Pro Val
275 280 285
Ala Ile Ile Gly Ala Ile Ser Leu Ala Ala Arg Arg Gly Ile Ile Val
290 295 300
Lys Asn Pro Gly Met Leu Glu Asn Ala Ser Gly Val Lys Thr Val Met
305 310 315 320
Phe Asp Lys Thr Gly Thr Leu Thr Tyr Gly Arg Pro Val Ile Thr Asp
325 330 335
Ile His Thr Ala Pro Gly Val Glu Glu Asp Thr Val Leu Ala Leu Ala
340 345 350
Ala Ser Val Glu Arg Tyr Ser Arg His Pro Leu Ala Asp Ala Ile Arg
355 360 365
Glu Gly Ala Lys Ala Arg Glu Leu His Leu Pro Asp Val Val Glu Val
370 375 380
Ser Glu Arg Pro Gly Gln Gly Leu Thr Gly Thr Val Gly Glu His Leu
385 390 395 400
Val Arg Ile Thr Asn Arg Arg Ser Thr Leu Glu Ile Asp Pro Asp Ser
405 410 415
Lys Asn Tyr Ile Pro Val Thr Ser Ser Gly Met Glu Ser Val Val Leu
420 425 430
Val Asp Asp Lys Tyr Ala Ala Leu Ile Arg Leu Arg Asp Glu Pro Arg
435 440 445
Ala Ser Ala Ser Glu Phe Ile Ala His Leu Pro Lys Lys His Lys Val
450 455 460
Asp Lys Leu Met Ile Ile Ser Gly Asp Arg Ala Ser Glu Val Arg Tyr
465 470 475 480
Leu Ala Asp Lys Val Gly Ile Asp Glu Val His Ala Glu Ala Ser Pro
485 490 495
Glu Asp Lys Leu Asn Ile Val Asn Arg His Asn Glu His Gly Ala Thr
500 505 510
Met Phe Leu Gly Asp Gly Ile Asn Asp Ala Pro Ala Met Ala Val Ala
515 520 525
Thr Val Gly Val Ala Met Gly Ala Asp Ser Asp Val Thr Ser Glu Ala
530 535 540
Ala Asp Ala Val Ile Leu Asp Ser Ser Leu Glu Arg Leu Asp Asp Leu
545 550 555 560
Leu His Ile Ser Ala Arg Met Arg Arg Ile Ala Leu Gln Ser Ala Gly
565 570 575
Gly Gly Met Ala Leu Ser Val Ile Gly Met Ile Leu Ala Val Phe Gly
580 585 590
Phe Leu Thr Pro Leu Met Gly Ala Ile Phe Gln Glu Val Ile Asp Val
595 600 605
Leu Ala Ile Leu Asn Ser Ala Arg Val Ala Leu Pro Arg Gly Ala Ile
610 615 620
Ser Asp Phe Asp Thr Gln Glu Lys Val Ser
625 630
<210> 581
<211> 1917
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1894)
<223> RXN00980
<400> 581
agagagaaag ggagaaatca tgaaaacgtg gaagacctgg ggggtcgtcg gagcttcagg 60
cctcttgatt attttgtcgt ggttgagttc atcgagcccg atg ctg gca gat gca 115
Met Leu Ala Asp Ala
1 5
ttc atg atc gcg gct gca att gtt gca ggt tgg ccg atc gcg cag tct 163
Phe Met Ile Ala Ala Ala Ile Val Ala Gly Trp Pro Ile Ala Gln Ser
10 15 20
gca tat caa gca ctt cgc att cga atg gtg tcg att gac tta ctg gtc 211
Ala Tyr Gln Ala Leu Arg Ile Arg Met Val Ser Ile Asp Leu Leu Val
25 30 35
gtt gtg gct gcc gtt ggt gcc atg ttc atc aac aac tat tgg gag tct 259
Val Val Ala Ala Val Gly Ala Met Phe Ile Asn Asn Tyr Trp Glu Ser
40 45 50
gcg gcg gtg acg ttc ctc ttt gcc ctt ggc aag gca ctg gaa cgc gcg 307
Ala Ala Val Thr Phe Leu Phe Ala Leu Gly Lys Ala Leu Glu Arg Ala
55 60 65
aca atg aac cgc aca cga aaa gca cta tcg gat ctg gtg gat gca gct 355
Thr Met Asn Arg Thr Arg Lys Ala Leu Ser Asp Leu Val Asp Ala Ala
70 75 80 85
cca gaa act gca aca agg ctc aac gcg gat gac tca aca gag gta gtt 403
Pro Glu Thr Ala Thr Arg Leu Asn Ala Asp Asp Ser Thr Glu Val Val
90 95 100
gag ctg tgg gag ctt gag ccc ggt gac atc gtc ttg gta cgc aat ggc 451
Glu Leu Trp Glu Leu Glu Pro Gly Asp Ile Val Leu Val Arg Asn Gly
105 110 115
gaa caa att ccc gtc gat gga aac gtg att gcg ggt gtc ggt gga att 499
Glu Gln Ile Pro Val Asp Gly Asn Val Ile Ala Gly Val Gly Gly Ile
120 125 130
gat gaa tcc aac atc acg ggt gaa tca atg ccg gct gaa aag ggt caa 547
Asp Glu Ser Asn Ile Thr Gly Glu Ser Met Pro Ala Glu Lys Gly Gln
135 140 145
ggc tct gat gtg tat gca gga acc tgg ctg cga tct ggt gtt ttg aga 595
Gly Ser Asp Val Tyr Ala Gly Thr Trp Leu Arg Ser Gly Val Leu Arg
150 155 160 165
gtc gag gca aca gga att ggt tca gac tca act ttg gca aaa atc att 643
Val Glu Ala Thr Gly Ile Gly Ser Asp Ser Thr Leu Ala Lys Ile Ile
170 175 180
cac cgc gtt gaa gac gcc cag gat gac aaa gcc cgc aca caa aca ttc 691
His Arg Val Glu Asp Ala Gln Asp Asp Lys Ala Arg Thr Gln Thr Phe
185 190 195
tta gag aaa ttc tct aag tgg tac acc ccg ggc gtc atg atc gcc gcc 739
Leu Glu Lys Phe Ser Lys Trp Tyr Thr Pro Gly Val Met Ile Ala Ala
200 205 210
gca gtg gtg gga ctt atc acc tgg gac gta gaa cta gca ctg acg ctc 787
Ala Val Val Gly Leu Ile Thr Trp Asp Val Glu Leu Ala Leu Thr Leu
215 220 225
tta gtg atc ggc tgc ccc ggc gcg ttg gtt atc tcc atc ccg gtg tcc 835
Leu Val Ile Gly Cys Pro Gly Ala Leu Val Ile Ser Ile Pro Val Ser
230 235 240 245
atc gtc gca ggc atc ggc cgt gct gca cgc gat ggc gtg ctg atc aag 883
Ile Val Ala Gly Ile Gly Arg Ala Ala Arg Asp Gly Val Leu Ile Lys
250 255 260
ggt gga gaa tac cta gaa acc gcc gcg aaa gtc gac gtc gtt gtc gtg 931
Gly Gly Glu Tyr Leu Glu Thr Ala Ala Lys Val Asp Val Val Val Val
265 270 275
gac aaa act gga acg ctg acc acc ggc cgc cca gaa ctc aca gac gta 979
Asp Lys Thr Gly Thr Leu Thr Thr Gly Arg Pro Glu Leu Thr Asp Val
280 285 290
gaa gtc atc gag ccc gcc tac agc cag ggc gag gtg ctg gag ctc gcc 1027
Glu Val Ile Glu Pro Ala Tyr Ser Gln Gly Glu Val Leu Glu Leu Ala
295 300 305
gcg cgc gcc gag acg gct tca gaa cat ccg ctt gcc gac gcc atc atc 1075
Ala Arg Ala Glu Thr Ala Ser Glu His Pro Leu Ala Asp Ala Ile Ile
310 315 320 325
cgt ggt gcc cag gat cgg ggg ctg tcc aca aca ttg gtg gaa gca gct 1123
Arg Gly Ala Gln Asp Arg Gly Leu Ser Thr Thr Leu Val Glu Ala Ala
330 335 340
gaa aac atc acc ggc cga ggc att atc gca aat gtt gat gga cag gca 1171
Glu Asn Ile Thr Gly Arg Gly Ile Ile Ala Asn Val Asp Gly Gln Ala
345 350 355
gtt gct gtt gga tct gct gag tta ctt gat cat gaa cca gac tcg acc 1219
Val Ala Val Gly Ser Ala Glu Leu Leu Asp His Glu Pro Asp Ser Thr
360 365 370
agg atc ctg gag cta aat gcc gaa gga aag acc gcg atg ttt gtc gga 1267
Arg Ile Leu Glu Leu Asn Ala Glu Gly Lys Thr Ala Met Phe Val Gly
375 380 385
gtg aac gga cac gcc att gga atc gtg gcc gtc gcc gac gcc gtt cgt 1315
Val Asn Gly His Ala Ile Gly Ile Val Ala Val Ala Asp Ala Val Arg
390 395 400 405
tca gat tct gcc tca gca atc gaa tcg ctg cat aag gcg ggc att caa 1363
Ser Asp Ser Ala Ser Ala Ile Glu Ser Leu His Lys Ala Gly Ile Gln
410 415 420
gtt gtc atg gcg act ggc gac gct cac cgc gtt gca caa aac gtg gcc 1411
Val Val Met Ala Thr Gly Asp Ala His Arg Val Ala Gln Asn Val Ala
425 430 435
tcc aag ctg gga gtg gat gaa gtc tac tca gag cta ctc cct gaa cag 1459
Ser Lys Leu Gly Val Asp Glu Val Tyr Ser Glu Leu Leu Pro Glu Gln
440 445 450
aaa tta gaa ctg gtg cgt gat ctg caa gct gcc ggc aaa acg gtc gcg 1507
Lys Leu Glu Leu Val Arg Asp Leu Gln Ala Ala Gly Lys Thr Val Ala
455 460 465
atg gtg ggt gac gga gtc aac gac acc cca gca ttg gca gct gct gat 1555
Met Val Gly Asp Gly Val Asn Asp Thr Pro Ala Leu Ala Ala Ala Asp
470 475 480 485
atc gga gta gcg atg ggc gtg gca ggt tcc cct gca gcc att gaa acc 1603
Ile Gly Val Ala Met Gly Val Ala Gly Ser Pro Ala Ala Ile Glu Thr
490 495 500
gct gat atc gca ctc atg gcg gat cgt ctc cca cgg ctg gca cat gca 1651
Ala Asp Ile Ala Leu Met Ala Asp Arg Leu Pro Arg Leu Ala His Ala
505 510 515
gtg acc ttg gca aaa cgc acc gta aga acc atg cgc atc aat att ctg 1699
Val Thr Leu Ala Lys Arg Thr Val Arg Thr Met Arg Ile Asn Ile Leu
520 525 530
att gcg ttg gct acc gtg atg gtg tta cta gct ggc gtc cta ttt ggc 1747
Ile Ala Leu Ala Thr Val Met Val Leu Leu Ala Gly Val Leu Phe Gly
535 540 545
gga gtt acc atg tcg gtt ggc atg ctc gtt cac gaa gca agc gtg ctg 1795
Gly Val Thr Met Ser Val Gly Met Leu Val His Glu Ala Ser Val Leu
550 555 560 565
ctt gtt atc agc atc gcc atg ctg ttg ctg cgt cca aca ctt aaa gaa 1843
Leu Val Ile Ser Ile Ala Met Leu Leu Leu Arg Pro Thr Leu Lys Glu
570 575 580
gat gct gcg caa gca agt gat att aaa cgc tcg gaa ata caa cag atc 1891
Asp Ala Ala Gln Ala Ser Asp Ile Lys Arg Ser Glu Ile Gln Gln Ile
585 590 595
gca taaccaatgg ctgggtactg atg 1917
Ala
<210> 582
<211> 598
<212> PRT
<213> Corynebacterium glutamicum
<400> 582
Met Leu Ala Asp Ala Phe Met Ile Ala Ala Ala Ile Val Ala Gly Trp
1 5 10 15
Pro Ile Ala Gln Ser Ala Tyr Gln Ala Leu Arg Ile Arg Met Val Ser
20 25 30
Ile Asp Leu Leu Val Val Val Ala Ala Val Gly Ala Met Phe Ile Asn
35 40 45
Asn Tyr Trp Glu Ser Ala Ala Val Thr Phe Leu Phe Ala Leu Gly Lys
50 55 60
Ala Leu Glu Arg Ala Thr Met Asn Arg Thr Arg Lys Ala Leu Ser Asp
65 70 75 80
Leu Val Asp Ala Ala Pro Glu Thr Ala Thr Arg Leu Asn Ala Asp Asp
85 90 95
Ser Thr Glu Val Val Glu Leu Trp Glu Leu Glu Pro Gly Asp Ile Val
100 105 110
Leu Val Arg Asn Gly Glu Gln Ile Pro Val Asp Gly Asn Val Ile Ala
115 120 125
Gly Val Gly Gly Ile Asp Glu Ser Asn Ile Thr Gly Glu Ser Met Pro
130 135 140
Ala Glu Lys Gly Gln Gly Ser Asp Val Tyr Ala Gly Thr Trp Leu Arg
145 150 155 160
Ser Gly Val Leu Arg Val Glu Ala Thr Gly Ile Gly Ser Asp Ser Thr
165 170 175
Leu Ala Lys Ile Ile His Arg Val Glu Asp Ala Gln Asp Asp Lys Ala
180 185 190
Arg Thr Gln Thr Phe Leu Glu Lys Phe Ser Lys Trp Tyr Thr Pro Gly
195 200 205
Val Met Ile Ala Ala Ala Val Val Gly Leu Ile Thr Trp Asp Val Glu
210 215 220
Leu Ala Leu Thr Leu Leu Val Ile Gly Cys Pro Gly Ala Leu Val Ile
225 230 235 240
Ser Ile Pro Val Ser Ile Val Ala Gly Ile Gly Arg Ala Ala Arg Asp
245 250 255
Gly Val Leu Ile Lys Gly Gly Glu Tyr Leu Glu Thr Ala Ala Lys Val
260 265 270
Asp Val Val Val Val Asp Lys Thr Gly Thr Leu Thr Thr Gly Arg Pro
275 280 285
Glu Leu Thr Asp Val Glu Val Ile Glu Pro Ala Tyr Ser Gln Gly Glu
290 295 300
Val Leu Glu Leu Ala Ala Arg Ala Glu Thr Ala Ser Glu His Pro Leu
305 310 315 320
Ala Asp Ala Ile Ile Arg Gly Ala Gln Asp Arg Gly Leu Ser Thr Thr
325 330 335
Leu Val Glu Ala Ala Glu Asn Ile Thr Gly Arg Gly Ile Ile Ala Asn
340 345 350
Val Asp Gly Gln Ala Val Ala Val Gly Ser Ala Glu Leu Leu Asp His
355 360 365
Glu Pro Asp Ser Thr Arg Ile Leu Glu Leu Asn Ala Glu Gly Lys Thr
370 375 380
Ala Met Phe Val Gly Val Asn Gly His Ala Ile Gly Ile Val Ala Val
385 390 395 400
Ala Asp Ala Val Arg Ser Asp Ser Ala Ser Ala Ile Glu Ser Leu His
405 410 415
Lys Ala Gly Ile Gln Val Val Met Ala Thr Gly Asp Ala His Arg Val
420 425 430
Ala Gln Asn Val Ala Ser Lys Leu Gly Val Asp Glu Val Tyr Ser Glu
435 440 445
Leu Leu Pro Glu Gln Lys Leu Glu Leu Val Arg Asp Leu Gln Ala Ala
450 455 460
Gly Lys Thr Val Ala Met Val Gly Asp Gly Val Asn Asp Thr Pro Ala
465 470 475 480
Leu Ala Ala Ala Asp Ile Gly Val Ala Met Gly Val Ala Gly Ser Pro
485 490 495
Ala Ala Ile Glu Thr Ala Asp Ile Ala Leu Met Ala Asp Arg Leu Pro
500 505 510
Arg Leu Ala His Ala Val Thr Leu Ala Lys Arg Thr Val Arg Thr Met
515 520 525
Arg Ile Asn Ile Leu Ile Ala Leu Ala Thr Val Met Val Leu Leu Ala
530 535 540
Gly Val Leu Phe Gly Gly Val Thr Met Ser Val Gly Met Leu Val His
545 550 555 560
Glu Ala Ser Val Leu Leu Val Ile Ser Ile Ala Met Leu Leu Leu Arg
565 570 575
Pro Thr Leu Lys Glu Asp Ala Ala Gln Ala Ser Asp Ile Lys Arg Ser
580 585 590
Glu Ile Gln Gln Ile Ala
595
<210> 583
<211> 1296
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1273)
<223> RXN00099
<400> 583
ctctggtgaa gaggatgttg actcgggaga ttcttccact gattcactga ttaagtggta 60
ccgcgcaaat aggtagtcgc ttgcttatag ggtcaggggc gtg aag aat cct cgc 115
Val Lys Asn Pro Arg
1 5
ctc ata gca ctg gcc gct atc atc ctg acc tcg ttc aat ctg cga aca 163
Leu Ile Ala Leu Ala Ala Ile Ile Leu Thr Ser Phe Asn Leu Arg Thr
10 15 20
gct att act gct tta gct ccg ctg gtt tct gag att cgg gat gat tta 211
Ala Ile Thr Ala Leu Ala Pro Leu Val Ser Glu Ile Arg Asp Asp Leu
25 30 35
ggg gtt agt gct tct ctt att ggt gtg ttg ggc atg atc ccg act gct 259
Gly Val Ser Ala Ser Leu Ile Gly Val Leu Gly Met Ile Pro Thr Ala
40 45 50
atg ttc gcg gat gct gcg ttt gcg ctt ccg tcg ttg aag agg aag ttc 307
Met Phe Ala Asp Ala Ala Phe Ala Leu Pro Ser Leu Lys Arg Lys Phe
55 60 65
act act tcc caa ctg ttg atg ttt gcc atg ctg ttg act gct gcc ggt 355
Thr Thr Ser Gln Leu Leu Met Phe Ala Met Leu Leu Thr Ala Ala Gly
70 75 80 85
cag att att cgt gtc gct gga cct gct tcg ctg ttg atg gtc ggt act 403
Gln Ile Ile Arg Val Ala Gly Pro Ala Ser Leu Leu Met Val Gly Thr
90 95 100
gtg ttc gcg atg ttt gcg atc gga gtt acc aat gtg ttg ctt ccg att 451
Val Phe Ala Met Phe Ala Ile Gly Val Thr Asn Val Leu Leu Pro Ile
105 110 115
gct gtt agg gag tat ttt ccg cgt cac gtc ggt gga atg tcg aca act 499
Ala Val Arg Glu Tyr Phe Pro Arg His Val Gly Gly Met Ser Thr Thr
120 125 130
tat ctg gtg tcg ttc cag att gtt cag gca ctt gct ccg acg ctt gcc 547
Tyr Leu Val Ser Phe Gln Ile Val Gln Ala Leu Ala Pro Thr Leu Ala
135 140 145
gtg ccg att tct cag tgg gct aca cat gtg ggg ttg acc ggt tgg agg 595
Val Pro Ile Ser Gln Trp Ala Thr His Val Gly Leu Thr Gly Trp Arg
150 155 160 165
gtg tcg ctc ggt tcg tgg gcg ctg ctg ggg ttg gtt gcg gcg att tcg 643
Val Ser Leu Gly Ser Trp Ala Leu Leu Gly Leu Val Ala Ala Ile Ser
170 175 180
tgg att ccg ctg ttg agt ttg cag ggt gcc agg gtt gtt gcg gcg ccg 691
Trp Ile Pro Leu Leu Ser Leu Gln Gly Ala Arg Val Val Ala Ala Pro
185 190 195
tcg aag gtt tct ctt cct gtg tgg aag tct tcg gtt ggt gtg ggg ctc 739
Ser Lys Val Ser Leu Pro Val Trp Lys Ser Ser Val Gly Val Gly Leu
200 205 210
ggg ttg atg ttt ggg ttt act tcg ttt gcg acg tat atc ctc atg ggt 787
Gly Leu Met Phe Gly Phe Thr Ser Phe Ala Thr Tyr Ile Leu Met Gly
215 220 225
ttt atg ccg cag atg gta ggt gat cct cag ctc ggt gcg gtg ttg tta 835
Phe Met Pro Gln Met Val Gly Asp Pro Gln Leu Gly Ala Val Leu Leu
230 235 240 245
ggc tgg tgg tca att ttg gga ttg ccg ctg aac att ctg gga ccg tgg 883
Gly Trp Trp Ser Ile Leu Gly Leu Pro Leu Asn Ile Leu Gly Pro Trp
250 255 260
ttg gtg acg cgt ttc act aac tgc ttc ccg atg gtt gtt atc gcc agt 931
Leu Val Thr Arg Phe Thr Asn Cys Phe Pro Met Val Val Ile Ala Ser
265 270 275
gtc atg ttt ctc atc ggt aat ggt ggg ttt tgt ttg gct ccg gat gtt 979
Val Met Phe Leu Ile Gly Asn Gly Gly Phe Cys Leu Ala Pro Asp Val
280 285 290
gcg ccg tgg ttg tgg gcg acg ttg tct ggt ctt ggt ccc ctt gcg ttc 1027
Ala Pro Trp Leu Trp Ala Thr Leu Ser Gly Leu Gly Pro Leu Ala Phe
295 300 305
ccg atg gcg ttg acg ctc att aat att cgt gct gaa act agt gct ggt 1075
Pro Met Ala Leu Thr Leu Ile Asn Ile Arg Ala Glu Thr Ser Ala Gly
310 315 320 325
gct tct gcg ttg agt tcc ttc ggg cag ggt ttg ggt tat acg att gcg 1123
Ala Ser Ala Leu Ser Ser Phe Gly Gln Gly Leu Gly Tyr Thr Ile Ala
330 335 340
tgt ttc ggt ccc ttg ttg act ggt ttc att gtc gat gcg aca ggc agc 1171
Cys Phe Gly Pro Leu Leu Thr Gly Phe Ile Val Asp Ala Thr Gly Ser
345 350 355
ttc cga aca atc ttt gtg ctt ttt gcg gtt gca aca ctc ttc gtt att 1219
Phe Arg Thr Ile Phe Val Leu Phe Ala Val Ala Thr Leu Phe Val Ile
360 365 370
aga ggc ggt tac ttt gcg aca agg cag gtt tac gtc gaa aag ctt tta 1267
Arg Gly Gly Tyr Phe Ala Thr Arg Gln Val Tyr Val Glu Lys Leu Leu
375 380 385
aat cgc taggatggcg ctatgccgca aag 1296
Asn Arg
390
<210> 584
<211> 391
<212> PRT
<213> Corynebacterium glutamicum
<400> 584
Val Lys Asn Pro Arg Leu Ile Ala Leu Ala Ala Ile Ile Leu Thr Ser
1 5 10 15
Phe Asn Leu Arg Thr Ala Ile Thr Ala Leu Ala Pro Leu Val Ser Glu
20 25 30
Ile Arg Asp Asp Leu Gly Val Ser Ala Ser Leu Ile Gly Val Leu Gly
35 40 45
Met Ile Pro Thr Ala Met Phe Ala Asp Ala Ala Phe Ala Leu Pro Ser
50 55 60
Leu Lys Arg Lys Phe Thr Thr Ser Gln Leu Leu Met Phe Ala Met Leu
65 70 75 80
Leu Thr Ala Ala Gly Gln Ile Ile Arg Val Ala Gly Pro Ala Ser Leu
85 90 95
Leu Met Val Gly Thr Val Phe Ala Met Phe Ala Ile Gly Val Thr Asn
100 105 110
Val Leu Leu Pro Ile Ala Val Arg Glu Tyr Phe Pro Arg His Val Gly
115 120 125
Gly Met Ser Thr Thr Tyr Leu Val Ser Phe Gln Ile Val Gln Ala Leu
130 135 140
Ala Pro Thr Leu Ala Val Pro Ile Ser Gln Trp Ala Thr His Val Gly
145 150 155 160
Leu Thr Gly Trp Arg Val Ser Leu Gly Ser Trp Ala Leu Leu Gly Leu
165 170 175
Val Ala Ala Ile Ser Trp Ile Pro Leu Leu Ser Leu Gln Gly Ala Arg
180 185 190
Val Val Ala Ala Pro Ser Lys Val Ser Leu Pro Val Trp Lys Ser Ser
195 200 205
Val Gly Val Gly Leu Gly Leu Met Phe Gly Phe Thr Ser Phe Ala Thr
210 215 220
Tyr Ile Leu Met Gly Phe Met Pro Gln Met Val Gly Asp Pro Gln Leu
225 230 235 240
Gly Ala Val Leu Leu Gly Trp Trp Ser Ile Leu Gly Leu Pro Leu Asn
245 250 255
Ile Leu Gly Pro Trp Leu Val Thr Arg Phe Thr Asn Cys Phe Pro Met
260 265 270
Val Val Ile Ala Ser Val Met Phe Leu Ile Gly Asn Gly Gly Phe Cys
275 280 285
Leu Ala Pro Asp Val Ala Pro Trp Leu Trp Ala Thr Leu Ser Gly Leu
290 295 300
Gly Pro Leu Ala Phe Pro Met Ala Leu Thr Leu Ile Asn Ile Arg Ala
305 310 315 320
Glu Thr Ser Ala Gly Ala Ser Ala Leu Ser Ser Phe Gly Gln Gly Leu
325 330 335
Gly Tyr Thr Ile Ala Cys Phe Gly Pro Leu Leu Thr Gly Phe Ile Val
340 345 350
Asp Ala Thr Gly Ser Phe Arg Thr Ile Phe Val Leu Phe Ala Val Ala
355 360 365
Thr Leu Phe Val Ile Arg Gly Gly Tyr Phe Ala Thr Arg Gln Val Tyr
370 375 380
Val Glu Lys Leu Leu Asn Arg
385 390
<210> 585
<211> 387
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(364)
<223> RXN02662
<400> 585
ccaaggtgtc accctcaccg ttgccatcgc cttcatcatc gtcaatatcg ccgtggacct 60
gctctacgtc ctggtcaatc cacgtattag gagcatctag atg cgc cgt aaa cta 115
Met Arg Arg Lys Leu
1 5
acc acc aca tta gaa aac aag ccc ggt gca cga ctt ggt ggc ttc cgc 163
Thr Thr Thr Leu Glu Asn Lys Pro Gly Ala Arg Leu Gly Gly Phe Arg
10 15 20
gca ctt gca cca act tca aaa atc gcg ctg gtt ttc ctt ctc ctg atc 211
Ala Leu Ala Pro Thr Ser Lys Ile Ala Leu Val Phe Leu Leu Leu Ile
25 30 35
ttc ctc ctc gcg atc ttt gcc cca ctg att gct aaa tac gat cca ctg 259
Phe Leu Leu Ala Ile Phe Ala Pro Leu Ile Ala Lys Tyr Asp Pro Leu
40 45 50
gcc tcc gga act cca gtc cag cct cca agc ggt gag cac tgg ttt ggt 307
Ala Ser Gly Thr Pro Val Gln Pro Pro Ser Gly Glu His Trp Phe Gly
55 60 65
acc gac gcc atc ggc cgc gat att ttc tcc cgc gta gcc acg gcg cca 355
Thr Asp Ala Ile Gly Arg Asp Ile Phe Ser Arg Val Ala Thr Ala Pro
70 75 80 85
gag cct ccc tgatcattgg tcttttcgct acg 387
Glu Pro Pro
<210> 586
<211> 88
<212> PRT
<213> Corynebacterium glutamicum
<400> 586
Met Arg Arg Lys Leu Thr Thr Thr Leu Glu Asn Lys Pro Gly Ala Arg
1 5 10 15
Leu Gly Gly Phe Arg Ala Leu Ala Pro Thr Ser Lys Ile Ala Leu Val
20 25 30
Phe Leu Leu Leu Ile Phe Leu Leu Ala Ile Phe Ala Pro Leu Ile Ala
35 40 45
Lys Tyr Asp Pro Leu Ala Ser Gly Thr Pro Val Gln Pro Pro Ser Gly
50 55 60
Glu His Trp Phe Gly Thr Asp Ala Ile Gly Arg Asp Ile Phe Ser Arg
65 70 75 80
Val Ala Thr Ala Pro Glu Pro Pro
85
<210> 587
<211> 972
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(949)
<223> RXN02442
<400> 587
gccgtgatgt tgttgagcgc gatgtgattg ccgtatgtgc atgtgagatt ccggacgctg 60
agttctgcca ttccttaatg ataacggtta tcattttcaa atg aag ttt ttt act 115
Met Lys Phe Phe Thr
1 5
gac gcc ctc ata gtg cct ttt gac gtt tca ttc atc tcc cgc gcc ctg 163
Asp Ala Leu Ile Val Pro Phe Asp Val Ser Phe Ile Ser Arg Ala Leu
10 15 20
gtc gcc gga tgc ctg gcc gca att tta tgc tca ctc att gga acg tgg 211
Val Ala Gly Cys Leu Ala Ala Ile Leu Cys Ser Leu Ile Gly Thr Trp
25 30 35
gtt att ttg cgc agg cta acc ttt ttc ggc gac gct atg tcg cac ggc 259
Val Ile Leu Arg Arg Leu Thr Phe Phe Gly Asp Ala Met Ser His Gly
40 45 50
ttg ctc ccc gga gta gcc acg gca tca cta ttg ggc gga aat ctc atg 307
Leu Leu Pro Gly Val Ala Thr Ala Ser Leu Leu Gly Gly Asn Leu Met
55 60 65
ttc ggc gca gca atc agc gca tta atc atg tca gcc gga gtg gtg tgg 355
Phe Gly Ala Ala Ile Ser Ala Leu Ile Met Ser Ala Gly Val Val Trp
70 75 80 85
acc agc aga aaa tcc agc ctc tcc caa gac gtc agc att ggc ctg caa 403
Thr Ser Arg Lys Ser Ser Leu Ser Gln Asp Val Ser Ile Gly Leu Gln
90 95 100
ttt att acc atg ctt tcc ctc ggc gtg gtt att gtg tcc cac tcc gat 451
Phe Ile Thr Met Leu Ser Leu Gly Val Val Ile Val Ser His Ser Asp
105 110 115
tcc cac gcc gta gac ctc acc agt ttc ctt ttt gga gac att ctt ggc 499
Ser His Ala Val Asp Leu Thr Ser Phe Leu Phe Gly Asp Ile Leu Gly
120 125 130
gtg cga ccc tcg gat ata ttc atc atc gcc att gca aca gtg ttg ggt 547
Val Arg Pro Ser Asp Ile Phe Ile Ile Ala Ile Ala Thr Val Leu Gly
135 140 145
gga ttg act att ttt ctc ttc cac cga cag ttc act gca ctc gct ttc 595
Gly Leu Thr Ile Phe Leu Phe His Arg Gln Phe Thr Ala Leu Ala Phe
150 155 160 165
gac gag cgt aaa gct cac acc tta gga ctc aat ccc cgc ttt gca cac 643
Asp Glu Arg Lys Ala His Thr Leu Gly Leu Asn Pro Arg Phe Ala His
170 175 180
cta ctc atg ctg gca ctg atc gca tta gct acg gtg gtg tcg ttt cag 691
Leu Leu Met Leu Ala Leu Ile Ala Leu Ala Thr Val Val Ser Phe Gln
185 190 195
gtg gtg gga acg ctt tta gtg ttt gga ctt ctc att ggt ccg ccc gcc 739
Val Val Gly Thr Leu Leu Val Phe Gly Leu Leu Ile Gly Pro Pro Ala
200 205 210
acg gct gca ctt tta gtg caa gac aaa gca agt att tca ctg atc atg 787
Thr Ala Ala Leu Leu Val Gln Asp Lys Ala Ser Ile Ser Leu Ile Met
215 220 225
atc gtc gcg tcg ctt ctt gga tgc gcg gaa att tac ctc ggg ctt tta 835
Ile Val Ala Ser Leu Leu Gly Cys Ala Glu Ile Tyr Leu Gly Leu Leu
230 235 240 245
atc agc tgg cac gca agc act gcc gcg gga gcc act atc act ttg tta 883
Ile Ser Trp His Ala Ser Thr Ala Ala Gly Ala Thr Ile Thr Leu Leu
250 255 260
agt gct gcg ata ttt ttt gcc acc tta ttg aca aag agt gcc att agt 931
Ser Ala Ala Ile Phe Phe Ala Thr Leu Leu Thr Lys Ser Ala Ile Ser
265 270 275
agg tta aac ttc acc gcg tgatactgaa agacattttc aat 972
Arg Leu Asn Phe Thr Ala
280
<210> 588
<211> 283
<212> PRT
<213> Corynebacterium glutamicum
<400> 588
Met Lys Phe Phe Thr Asp Ala Leu Ile Val Pro Phe Asp Val Ser Phe
1 5 10 15
Ile Ser Arg Ala Leu Val Ala Gly Cys Leu Ala Ala Ile Leu Cys Ser
20 25 30
Leu Ile Gly Thr Trp Val Ile Leu Arg Arg Leu Thr Phe Phe Gly Asp
35 40 45
Ala Met Ser His Gly Leu Leu Pro Gly Val Ala Thr Ala Ser Leu Leu
50 55 60
Gly Gly Asn Leu Met Phe Gly Ala Ala Ile Ser Ala Leu Ile Met Ser
65 70 75 80
Ala Gly Val Val Trp Thr Ser Arg Lys Ser Ser Leu Ser Gln Asp Val
85 90 95
Ser Ile Gly Leu Gln Phe Ile Thr Met Leu Ser Leu Gly Val Val Ile
100 105 110
Val Ser His Ser Asp Ser His Ala Val Asp Leu Thr Ser Phe Leu Phe
115 120 125
Gly Asp Ile Leu Gly Val Arg Pro Ser Asp Ile Phe Ile Ile Ala Ile
130 135 140
Ala Thr Val Leu Gly Gly Leu Thr Ile Phe Leu Phe His Arg Gln Phe
145 150 155 160
Thr Ala Leu Ala Phe Asp Glu Arg Lys Ala His Thr Leu Gly Leu Asn
165 170 175
Pro Arg Phe Ala His Leu Leu Met Leu Ala Leu Ile Ala Leu Ala Thr
180 185 190
Val Val Ser Phe Gln Val Val Gly Thr Leu Leu Val Phe Gly Leu Leu
195 200 205
Ile Gly Pro Pro Ala Thr Ala Ala Leu Leu Val Gln Asp Lys Ala Ser
210 215 220
Ile Ser Leu Ile Met Ile Val Ala Ser Leu Leu Gly Cys Ala Glu Ile
225 230 235 240
Tyr Leu Gly Leu Leu Ile Ser Trp His Ala Ser Thr Ala Ala Gly Ala
245 250 255
Thr Ile Thr Leu Leu Ser Ala Ala Ile Phe Phe Ala Thr Leu Leu Thr
260 265 270
Lys Ser Ala Ile Ser Arg Leu Asn Phe Thr Ala
275 280
<210> 589
<211> 1077
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1054)
<223> RXN02443
<400> 589
caagcactgc cgcgggagcc actatcactt tgttaagtgc tgcgatattt tttgccacct 60
tattgacaaa gagtgccatt agtaggttaa acttcaccgc gtg ata ctg aaa gac 115
Val Ile Leu Lys Asp
1 5
att ttc aat aat ggg gag ctc ttt ggg gct tcc tcc gcg aaa aat ttc 163
Ile Phe Asn Asn Gly Glu Leu Phe Gly Ala Ser Ser Ala Lys Asn Phe
10 15 20
cga aaa cta cta gct gtt cca gcc gtt gcc gcc tca cta gct ttt ggt 211
Arg Lys Leu Leu Ala Val Pro Ala Val Ala Ala Ser Leu Ala Phe Gly
25 30 35
atc acc gcc tgt tcc gct gta gat gac acc cct gac att gtg gtc acc 259
Ile Thr Ala Cys Ser Ala Val Asp Asp Thr Pro Asp Ile Val Val Thr
40 45 50
acc aac atc ctg ggt gat gtt gta agc cat atc gtg gga gat tcc gca 307
Thr Asn Ile Leu Gly Asp Val Val Ser His Ile Val Gly Asp Ser Ala
55 60 65
gat gtc caa gta ctc atg aaa ccc aac gca gat cca cat tcc ttc gga 355
Asp Val Gln Val Leu Met Lys Pro Asn Ala Asp Pro His Ser Phe Gly
70 75 80 85
gtc tca gca caa gac gcc gct gcc atg gaa cat gcc gat ctc atc gtg 403
Val Ser Ala Gln Asp Ala Ala Ala Met Glu His Ala Asp Leu Ile Val
90 95 100
gcc aat gga cta gga ctt gaa gag ggc ctt caa tcc aat gtg gac aat 451
Ala Asn Gly Leu Gly Leu Glu Glu Gly Leu Gln Ser Asn Val Asp Asn
105 110 115
gcc aaa agc caa ggg gtt ccc gtc ttg gaa gtc ggc gaa cac atc gat 499
Ala Lys Ser Gln Gly Val Pro Val Leu Glu Val Gly Glu His Ile Asp
120 125 130
gtc att gac tac tcc ccc ggc gtt cca gat cct cac ttt tgg aca gac 547
Val Ile Asp Tyr Ser Pro Gly Val Pro Asp Pro His Phe Trp Thr Asp
135 140 145
ccg gcg cgc atg atc gcc gcc acg gaa gtt ata gaa gct gaa ctg atc 595
Pro Ala Arg Met Ile Ala Ala Thr Glu Val Ile Glu Ala Glu Leu Ile
150 155 160 165
aaa gaa ctc gat cct tcc ctg act gaa tcg atc aca caa tca gcc cag 643
Lys Glu Leu Asp Pro Ser Leu Thr Glu Ser Ile Thr Gln Ser Ala Gln
170 175 180
cac tac cgt gag gaa ctt gtt gcc ctt gat gag gaa gtc acc gaa ttg 691
His Tyr Arg Glu Glu Leu Val Ala Leu Asp Glu Glu Val Thr Glu Leu
185 190 195
ctc agc ggc gtg gcc cca gaa aac cgc aag ctg gta acc aat cac aat 739
Leu Ser Gly Val Ala Pro Glu Asn Arg Lys Leu Val Thr Asn His Asn
200 205 210
gtt ttt gga tac ctg gcc agc cgg ttt aac tac acc gtc att gac acc 787
Val Phe Gly Tyr Leu Ala Ser Arg Phe Asn Tyr Thr Val Ile Asp Thr
215 220 225
atc atc cca ggt gga agc aca ttg gcg gcg cct tca gca tct gac ctc 835
Ile Ile Pro Gly Gly Ser Thr Leu Ala Ala Pro Ser Ala Ser Asp Leu
230 235 240 245
aat gac atc tcc acc gcc atc gaa gac aac aat gtt ccc gca atc ttc 883
Asn Asp Ile Ser Thr Ala Ile Glu Asp Asn Asn Val Pro Ala Ile Phe
250 255 260
acc gat acc tca agc cca caa cgg tta gct gaa gtg ttg gcc agc aac 931
Thr Asp Thr Ser Ser Pro Gln Arg Leu Ala Glu Val Leu Ala Ser Asn
265 270 275
gct ggc att gat gtt caa gtg gtg tcc att ttc acg gaa tca ctc acc 979
Ala Gly Ile Asp Val Gln Val Val Ser Ile Phe Thr Glu Ser Leu Thr
280 285 290
gat gca gat ggt gaa gca ccc acc tac atc agc atg caa aaa atc aat 1027
Asp Ala Asp Gly Glu Ala Pro Thr Tyr Ile Ser Met Gln Lys Ile Asn
295 300 305
gcc gag cgc att gca agc act ttg tcc taaacagtcc taaacagtct 1074
Ala Glu Arg Ile Ala Ser Thr Leu Ser
310 315
taa 1077
<210> 590
<211> 318
<212> PRT
<213> Corynebacterium glutamicum
<400> 590
Val Ile Leu Lys Asp Ile Phe Asn Asn Gly Glu Leu Phe Gly Ala Ser
1 5 10 15
Ser Ala Lys Asn Phe Arg Lys Leu Leu Ala Val Pro Ala Val Ala Ala
20 25 30
Ser Leu Ala Phe Gly Ile Thr Ala Cys Ser Ala Val Asp Asp Thr Pro
35 40 45
Asp Ile Val Val Thr Thr Asn Ile Leu Gly Asp Val Val Ser His Ile
50 55 60
Val Gly Asp Ser Ala Asp Val Gln Val Leu Met Lys Pro Asn Ala Asp
65 70 75 80
Pro His Ser Phe Gly Val Ser Ala Gln Asp Ala Ala Ala Met Glu His
85 90 95
Ala Asp Leu Ile Val Ala Asn Gly Leu Gly Leu Glu Glu Gly Leu Gln
100 105 110
Ser Asn Val Asp Asn Ala Lys Ser Gln Gly Val Pro Val Leu Glu Val
115 120 125
Gly Glu His Ile Asp Val Ile Asp Tyr Ser Pro Gly Val Pro Asp Pro
130 135 140
His Phe Trp Thr Asp Pro Ala Arg Met Ile Ala Ala Thr Glu Val Ile
145 150 155 160
Glu Ala Glu Leu Ile Lys Glu Leu Asp Pro Ser Leu Thr Glu Ser Ile
165 170 175
Thr Gln Ser Ala Gln His Tyr Arg Glu Glu Leu Val Ala Leu Asp Glu
180 185 190
Glu Val Thr Glu Leu Leu Ser Gly Val Ala Pro Glu Asn Arg Lys Leu
195 200 205
Val Thr Asn His Asn Val Phe Gly Tyr Leu Ala Ser Arg Phe Asn Tyr
210 215 220
Thr Val Ile Asp Thr Ile Ile Pro Gly Gly Ser Thr Leu Ala Ala Pro
225 230 235 240
Ser Ala Ser Asp Leu Asn Asp Ile Ser Thr Ala Ile Glu Asp Asn Asn
245 250 255
Val Pro Ala Ile Phe Thr Asp Thr Ser Ser Pro Gln Arg Leu Ala Glu
260 265 270
Val Leu Ala Ser Asn Ala Gly Ile Asp Val Gln Val Val Ser Ile Phe
275 280 285
Thr Glu Ser Leu Thr Asp Ala Asp Gly Glu Ala Pro Thr Tyr Ile Ser
290 295 300
Met Gln Lys Ile Asn Ala Glu Arg Ile Ala Ser Thr Leu Ser
305 310 315
<210> 591
<211> 1323
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1300)
<223> RXN00842
<400> 591
ccttgtcgcg gaggtaagcg agggtatttc tggatgtgga acaacgcgga ttatggaaaa 60
tcgtgacttt cataacgttg agcctactaa ggtttgttcc atg att att caa atc 115
Met Ile Ile Gln Ile
1 5
cta aga gtg gca ttt gcc ttc gtc ggc atc att gtt ggc gcc ggt ttc 163
Leu Arg Val Ala Phe Ala Phe Val Gly Ile Ile Val Gly Ala Gly Phe
10 15 20
gca tca ggg caa gag gtc atg caa tat ttt gtg gcc ttc ggc ata gac 211
Ala Ser Gly Gln Glu Val Met Gln Tyr Phe Val Ala Phe Gly Ile Asp
25 30 35
gga att tgg gga gtc att gtt tct gca gtg atc atg tcg gtg atg gcg 259
Gly Ile Trp Gly Val Ile Val Ser Ala Val Ile Met Ser Val Met Ala
40 45 50
ttg atc att ttg cag ctc gga agc tat ttc aat gca ggt gaa cac ggt 307
Leu Ile Ile Leu Gln Leu Gly Ser Tyr Phe Asn Ala Gly Glu His Gly
55 60 65
gaa gtg ttc cgc cga gta agt cac ccc gtt ttc tcc aaa att ttg gac 355
Glu Val Phe Arg Arg Val Ser His Pro Val Phe Ser Lys Ile Leu Asp
70 75 80 85
atc ggc gtt gtg gtg acg ttg ttc tcc acc ggt ttc gtc atg ttt gca 403
Ile Gly Val Val Val Thr Leu Phe Ser Thr Gly Phe Val Met Phe Ala
90 95 100
ggc gcg gga tca aat ctg aat cag cag tgg ggg ctt ccg ctc tgg atc 451
Gly Ala Gly Ser Asn Leu Asn Gln Gln Trp Gly Leu Pro Leu Trp Ile
105 110 115
ggt tct gtg atc atg gtt ctt ctg gtg ctg gct gcg ggc atg ttg gac 499
Gly Ser Val Ile Met Val Leu Leu Val Leu Ala Ala Gly Met Leu Asp
120 125 130
gtg gat aaa gta acc aca gtc att ggt gca att act ccg ttc atc atc 547
Val Asp Lys Val Thr Thr Val Ile Gly Ala Ile Thr Pro Phe Ile Ile
135 140 145
att ttc atc act gcc gcc tcg atc tac acg ctg gta ggt aat ttc agc 595
Ile Phe Ile Thr Ala Ala Ser Ile Tyr Thr Leu Val Gly Asn Phe Ser
150 155 160 165
tca gtg gag cag ctt gat tct gct gct tta gaa gtc ggc acg acg ttg 643
Ser Val Glu Gln Leu Asp Ser Ala Ala Leu Glu Val Gly Thr Thr Leu
170 175 180
cct cac tgg gct gtt gca gcg gtg aac tat gtg gga ttc aac ctg atg 691
Pro His Trp Ala Val Ala Ala Val Asn Tyr Val Gly Phe Asn Leu Met
185 190 195
gtt gcg gtg tcc atg gct gtg gtc att ggt gga tca atg ttt aac ccg 739
Val Ala Val Ser Met Ala Val Val Ile Gly Gly Ser Met Phe Asn Pro
200 205 210
cgg gtc gca ggt cgg ggc ggt ttg ctg ggc gga ttg atc ctg gga ttc 787
Arg Val Ala Gly Arg Gly Gly Leu Leu Gly Gly Leu Ile Leu Gly Phe
215 220 225
ttg atc atc atc agt gcg cta aca ctg ttc gcc acc gtg gaa gaa gtt 835
Leu Ile Ile Ile Ser Ala Leu Thr Leu Phe Ala Thr Val Glu Glu Val
230 235 240 245
ggc caa gat gat atg cct atg ctg acg atc atc aac aat ttg aac ccg 883
Gly Gln Asp Asp Met Pro Met Leu Thr Ile Ile Asn Asn Leu Asn Pro
250 255 260
ctg gct ggc caa gta atg gca gtg gtt atc tac gga atg atc ttc aac 931
Leu Ala Gly Gln Val Met Ala Val Val Ile Tyr Gly Met Ile Phe Asn
265 270 275
acg gca ctg ggt atg ttc tac gca ttg ggc cgt cgt ctc act gcg aaa 979
Thr Ala Leu Gly Met Phe Tyr Ala Leu Gly Arg Arg Leu Thr Ala Lys
280 285 290
aac cca cag cga ttc cgt ccg gtt tat gtg gtc aca gtg ctg att ggt 1027
Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val Thr Val Leu Ile Gly
295 300 305
ttt gtg ttg agc ttt gtg gga ttc aag aac ttg gtg ggc tat gtg tac 1075
Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu Val Gly Tyr Val Tyr
310 315 320 325
cca gtc ttg gga tac att ggc ctg ctg ctg att gca gtg atg atg gtg 1123
Pro Val Leu Gly Tyr Ile Gly Leu Leu Leu Ile Ala Val Met Met Val
330 335 340
gcg tgg gtg agg gga cgc gta cgc atc tac aag gaa tcc gaa cgc cgc 1171
Ala Trp Val Arg Gly Arg Val Arg Ile Tyr Lys Glu Ser Glu Arg Arg
345 350 355
atg cgg atc gca gac ttg ttg cag atc ggc cat gac gga gcg ttg agt 1219
Met Arg Ile Ala Asp Leu Leu Gln Ile Gly His Asp Gly Ala Leu Ser
360 365 370
gga gca gag ctg gcg gtg ctc aac cag gaa atc caa gat tca aac ttg 1267
Gly Ala Glu Leu Ala Val Leu Asn Gln Glu Ile Gln Asp Ser Asn Leu
375 380 385
gat gag gaa caa att aaa gca gcg gtt agg aag tagttactct gcagggacga 1320
Asp Glu Glu Gln Ile Lys Ala Ala Val Arg Lys
390 395 400
gct 1323
<210> 592
<211> 400
<212> PRT
<213> Corynebacterium glutamicum
<400> 592
Met Ile Ile Gln Ile Leu Arg Val Ala Phe Ala Phe Val Gly Ile Ile
1 5 10 15
Val Gly Ala Gly Phe Ala Ser Gly Gln Glu Val Met Gln Tyr Phe Val
20 25 30
Ala Phe Gly Ile Asp Gly Ile Trp Gly Val Ile Val Ser Ala Val Ile
35 40 45
Met Ser Val Met Ala Leu Ile Ile Leu Gln Leu Gly Ser Tyr Phe Asn
50 55 60
Ala Gly Glu His Gly Glu Val Phe Arg Arg Val Ser His Pro Val Phe
65 70 75 80
Ser Lys Ile Leu Asp Ile Gly Val Val Val Thr Leu Phe Ser Thr Gly
85 90 95
Phe Val Met Phe Ala Gly Ala Gly Ser Asn Leu Asn Gln Gln Trp Gly
100 105 110
Leu Pro Leu Trp Ile Gly Ser Val Ile Met Val Leu Leu Val Leu Ala
115 120 125
Ala Gly Met Leu Asp Val Asp Lys Val Thr Thr Val Ile Gly Ala Ile
130 135 140
Thr Pro Phe Ile Ile Ile Phe Ile Thr Ala Ala Ser Ile Tyr Thr Leu
145 150 155 160
Val Gly Asn Phe Ser Ser Val Glu Gln Leu Asp Ser Ala Ala Leu Glu
165 170 175
Val Gly Thr Thr Leu Pro His Trp Ala Val Ala Ala Val Asn Tyr Val
180 185 190
Gly Phe Asn Leu Met Val Ala Val Ser Met Ala Val Val Ile Gly Gly
195 200 205
Ser Met Phe Asn Pro Arg Val Ala Gly Arg Gly Gly Leu Leu Gly Gly
210 215 220
Leu Ile Leu Gly Phe Leu Ile Ile Ile Ser Ala Leu Thr Leu Phe Ala
225 230 235 240
Thr Val Glu Glu Val Gly Gln Asp Asp Met Pro Met Leu Thr Ile Ile
245 250 255
Asn Asn Leu Asn Pro Leu Ala Gly Gln Val Met Ala Val Val Ile Tyr
260 265 270
Gly Met Ile Phe Asn Thr Ala Leu Gly Met Phe Tyr Ala Leu Gly Arg
275 280 285
Arg Leu Thr Ala Lys Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val
290 295 300
Thr Val Leu Ile Gly Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu
305 310 315 320
Val Gly Tyr Val Tyr Pro Val Leu Gly Tyr Ile Gly Leu Leu Leu Ile
325 330 335
Ala Val Met Met Val Ala Trp Val Arg Gly Arg Val Arg Ile Tyr Lys
340 345 350
Glu Ser Glu Arg Arg Met Arg Ile Ala Asp Leu Leu Gln Ile Gly His
355 360 365
Asp Gly Ala Leu Ser Gly Ala Glu Leu Ala Val Leu Asn Gln Glu Ile
370 375 380
Gln Asp Ser Asn Leu Asp Glu Glu Gln Ile Lys Ala Ala Val Arg Lys
385 390 395 400
<210> 593
<211> 1323
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1300)
<223> FRXA00842
<400> 593
ccttgtcgcg gaggtaagcg agggtatttc tggatgtgga acaacgcgga ttatggaaaa 60
tcgtgacttt cataacgttg agcctactaa ggtttgttcc atg att att caa atc 115
Met Ile Ile Gln Ile
1 5
cta aga gtg gca ttt gcc ttc gtc ggc atc att gtt ggc gcc ggt ttc 163
Leu Arg Val Ala Phe Ala Phe Val Gly Ile Ile Val Gly Ala Gly Phe
10 15 20
gca tca ggg caa gag gtc atg caa tat ttt gtg gcc ttc ggc ata gac 211
Ala Ser Gly Gln Glu Val Met Gln Tyr Phe Val Ala Phe Gly Ile Asp
25 30 35
gga att tgg gga gtc att gtt tct gca gtg atc atg tcg gtg atg gcg 259
Gly Ile Trp Gly Val Ile Val Ser Ala Val Ile Met Ser Val Met Ala
40 45 50
ttg atc att ttg cag ctc gga agc tat ttc aat gca ggt gaa cac ggt 307
Leu Ile Ile Leu Gln Leu Gly Ser Tyr Phe Asn Ala Gly Glu His Gly
55 60 65
gaa gtg ttc cgc cga gta agt cac ccc gtt ttc tcc aaa att ttg gac 355
Glu Val Phe Arg Arg Val Ser His Pro Val Phe Ser Lys Ile Leu Asp
70 75 80 85
atc ggc gtt gtg gtg acg ttg ttc tcc acc ggt ttc gtc atg ttt gca 403
Ile Gly Val Val Val Thr Leu Phe Ser Thr Gly Phe Val Met Phe Ala
90 95 100
ggc gcg gga tca aat ctg aat cag cag tgg ggg ctt ccg ctc tgg atc 451
Gly Ala Gly Ser Asn Leu Asn Gln Gln Trp Gly Leu Pro Leu Trp Ile
105 110 115
ggt tct gtg atc atg gtt ctt ctg gtg ctg gct gcg ggc atg ttg gac 499
Gly Ser Val Ile Met Val Leu Leu Val Leu Ala Ala Gly Met Leu Asp
120 125 130
gtg gat aaa gta acc aca gtc att ggt gca att act ccg ttc atc atc 547
Val Asp Lys Val Thr Thr Val Ile Gly Ala Ile Thr Pro Phe Ile Ile
135 140 145
att ttc atc act gcc gcc tcg atc tac acg ctg gta ggt aat ttc agc 595
Ile Phe Ile Thr Ala Ala Ser Ile Tyr Thr Leu Val Gly Asn Phe Ser
150 155 160 165
tca gtg gag cag ctt gat tct gct gct tta gaa gtc ggc acg acg ttg 643
Ser Val Glu Gln Leu Asp Ser Ala Ala Leu Glu Val Gly Thr Thr Leu
170 175 180
cct cac tgg gct gtt gca gcg gtg aac tat gtg gga ttc aac ctg atg 691
Pro His Trp Ala Val Ala Ala Val Asn Tyr Val Gly Phe Asn Leu Met
185 190 195
gtt gcg gtg tcc atg gct gtg gtc att ggt gga tca atg ttt aac ccg 739
Val Ala Val Ser Met Ala Val Val Ile Gly Gly Ser Met Phe Asn Pro
200 205 210
cgg gtc gca ggt cgg ggc ggt ttg ctg ggc gga ttg atc ctg gga ttc 787
Arg Val Ala Gly Arg Gly Gly Leu Leu Gly Gly Leu Ile Leu Gly Phe
215 220 225
ttg atc atc atc agt gcg cta aca ctg ttc gcc acc gtg gaa gaa gtt 835
Leu Ile Ile Ile Ser Ala Leu Thr Leu Phe Ala Thr Val Glu Glu Val
230 235 240 245
ggc caa gat gat atg cct atg ctg acg atc atc aac aat ttg aac ccg 883
Gly Gln Asp Asp Met Pro Met Leu Thr Ile Ile Asn Asn Leu Asn Pro
250 255 260
ctg gct ggc caa gta atg gca gtg gtt atc tac gga atg atc ttc aac 931
Leu Ala Gly Gln Val Met Ala Val Val Ile Tyr Gly Met Ile Phe Asn
265 270 275
acg gca ctg ggt atg ttc tac gca ttg ggc cgt cgt ctc act gcg aaa 979
Thr Ala Leu Gly Met Phe Tyr Ala Leu Gly Arg Arg Leu Thr Ala Lys
280 285 290
aac cca cag cga ttc cgt ccg gtt tat gtg gtc aca gtg ctg att ggt 1027
Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val Thr Val Leu Ile Gly
295 300 305
ttt gtg ttg agc ttt gtg gga ttc aag aac ttg gtg ggc tat gtg tac 1075
Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu Val Gly Tyr Val Tyr
310 315 320 325
cca gtc ttg gga tac att ggc ctg ctg ctg att gca gtg atg atg gtg 1123
Pro Val Leu Gly Tyr Ile Gly Leu Leu Leu Ile Ala Val Met Met Val
330 335 340
gcg tgg gtg agg gga cgc gta cgc atc tac aag gaa tcc gaa cgc cgc 1171
Ala Trp Val Arg Gly Arg Val Arg Ile Tyr Lys Glu Ser Glu Arg Arg
345 350 355
atg cgg atc gca gac ttg ttg cag atc ggc cat gac gga gcg ttg agt 1219
Met Arg Ile Ala Asp Leu Leu Gln Ile Gly His Asp Gly Ala Leu Ser
360 365 370
gga gca gag ctg gcg gtg ctc aac cag gaa atc caa gat tca aac ttg 1267
Gly Ala Glu Leu Ala Val Leu Asn Gln Glu Ile Gln Asp Ser Asn Leu
375 380 385
gat gag gaa caa att aaa gca gcg gtt agg aag tagttactct gcagggacga 1320
Asp Glu Glu Gln Ile Lys Ala Ala Val Arg Lys
390 395 400
gct 1323
<210> 594
<211> 400
<212> PRT
<213> Corynebacterium glutamicum
<400> 594
Met Ile Ile Gln Ile Leu Arg Val Ala Phe Ala Phe Val Gly Ile Ile
1 5 10 15
Val Gly Ala Gly Phe Ala Ser Gly Gln Glu Val Met Gln Tyr Phe Val
20 25 30
Ala Phe Gly Ile Asp Gly Ile Trp Gly Val Ile Val Ser Ala Val Ile
35 40 45
Met Ser Val Met Ala Leu Ile Ile Leu Gln Leu Gly Ser Tyr Phe Asn
50 55 60
Ala Gly Glu His Gly Glu Val Phe Arg Arg Val Ser His Pro Val Phe
65 70 75 80
Ser Lys Ile Leu Asp Ile Gly Val Val Val Thr Leu Phe Ser Thr Gly
85 90 95
Phe Val Met Phe Ala Gly Ala Gly Ser Asn Leu Asn Gln Gln Trp Gly
100 105 110
Leu Pro Leu Trp Ile Gly Ser Val Ile Met Val Leu Leu Val Leu Ala
115 120 125
Ala Gly Met Leu Asp Val Asp Lys Val Thr Thr Val Ile Gly Ala Ile
130 135 140
Thr Pro Phe Ile Ile Ile Phe Ile Thr Ala Ala Ser Ile Tyr Thr Leu
145 150 155 160
Val Gly Asn Phe Ser Ser Val Glu Gln Leu Asp Ser Ala Ala Leu Glu
165 170 175
Val Gly Thr Thr Leu Pro His Trp Ala Val Ala Ala Val Asn Tyr Val
180 185 190
Gly Phe Asn Leu Met Val Ala Val Ser Met Ala Val Val Ile Gly Gly
195 200 205
Ser Met Phe Asn Pro Arg Val Ala Gly Arg Gly Gly Leu Leu Gly Gly
210 215 220
Leu Ile Leu Gly Phe Leu Ile Ile Ile Ser Ala Leu Thr Leu Phe Ala
225 230 235 240
Thr Val Glu Glu Val Gly Gln Asp Asp Met Pro Met Leu Thr Ile Ile
245 250 255
Asn Asn Leu Asn Pro Leu Ala Gly Gln Val Met Ala Val Val Ile Tyr
260 265 270
Gly Met Ile Phe Asn Thr Ala Leu Gly Met Phe Tyr Ala Leu Gly Arg
275 280 285
Arg Leu Thr Ala Lys Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val
290 295 300
Thr Val Leu Ile Gly Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu
305 310 315 320
Val Gly Tyr Val Tyr Pro Val Leu Gly Tyr Ile Gly Leu Leu Leu Ile
325 330 335
Ala Val Met Met Val Ala Trp Val Arg Gly Arg Val Arg Ile Tyr Lys
340 345 350
Glu Ser Glu Arg Arg Met Arg Ile Ala Asp Leu Leu Gln Ile Gly His
355 360 365
Asp Gly Ala Leu Ser Gly Ala Glu Leu Ala Val Leu Asn Gln Glu Ile
370 375 380
Gln Asp Ser Asn Leu Asp Glu Glu Gln Ile Lys Ala Ala Val Arg Lys
385 390 395 400
<210> 595
<211> 1173
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1150)
<223> RXN00832
<400> 595
gagattgtgc taggttctga tgaggcttcg ggacgacccg aagaaatcta tgacagcctg 60
ggaacggccc agagttctta agaaagtttg actagagaac atg ccg ttt tct tgg 115
Met Pro Phe Ser Trp
1 5
cta aaa cca att gat tat gcc cgc atc ttt gtc ggc tgg gca tcg att 163
Leu Lys Pro Ile Asp Tyr Ala Arg Ile Phe Val Gly Trp Ala Ser Ile
10 15 20
ttt atc atc ccc ctc atc aca ctg cca tca att att gag ttg gcg ctg 211
Phe Ile Ile Pro Leu Ile Thr Leu Pro Ser Ile Ile Glu Leu Ala Leu
25 30 35
atc gtg gca gtc atc cta ttc tgc gca ttt ggc gtg gtg aag atg gcg 259
Ile Val Ala Val Ile Leu Phe Cys Ala Phe Gly Val Val Lys Met Ala
40 45 50
gag cgt ttg gct cat att ttg ggt gat cct ttt gga tcg ttg atc ctt 307
Glu Arg Leu Ala His Ile Leu Gly Asp Pro Phe Gly Ser Leu Ile Leu
55 60 65
acc ttg tcg atc gtg atc att gaa gtg att ttg atc tgt gcg gtg atg 355
Thr Leu Ser Ile Val Ile Ile Glu Val Ile Leu Ile Cys Ala Val Met
70 75 80 85
ctg ggg cct gct gat tca acc act gct ggt cgg gat tcc gtg atg gca 403
Leu Gly Pro Ala Asp Ser Thr Thr Ala Gly Arg Asp Ser Val Met Ala
90 95 100
gtg tcc atg atc atc atg ggt ttg gtc gtg gga ttg tgc cta ctc att 451
Val Ser Met Ile Ile Met Gly Leu Val Val Gly Leu Cys Leu Leu Ile
105 110 115
ggt ggt tta agg cat gga agc atg cca cac aat ggg gtg gga act ccg 499
Gly Gly Leu Arg His Gly Ser Met Pro His Asn Gly Val Gly Thr Pro
120 125 130
acc tac ttg gtg ctg atc gca act ttt tcc gta atc gcc ttt gcg gtt 547
Thr Tyr Leu Val Leu Ile Ala Thr Phe Ser Val Ile Ala Phe Ala Val
135 140 145
cca gct ttc agg gga gaa tac tcc act ggg cag gca ctt gtt att tca 595
Pro Ala Phe Arg Gly Glu Tyr Ser Thr Gly Gln Ala Leu Val Ile Ser
150 155 160 165
aca ctg aca gca gtg gtg tac ggg ttc ttc ctg ttt cgc caa atg ggt 643
Thr Leu Thr Ala Val Val Tyr Gly Phe Phe Leu Phe Arg Gln Met Gly
170 175 180
gcc caa gct ggt gaa ttt caa gag gtc gag gtc gca gaa aag gca gac 691
Ala Gln Ala Gly Glu Phe Gln Glu Val Glu Val Ala Glu Lys Ala Asp
185 190 195
gac gca gca aaa tgg gag gtc cca ttt aga ggc tta atc ttg att atc 739
Asp Ala Ala Lys Trp Glu Val Pro Phe Arg Gly Leu Ile Leu Ile Ile
200 205 210
act gtg ctc ccc atc gtg ttg ctg tcc cat gac atg gcc acg gtg atg 787
Thr Val Leu Pro Ile Val Leu Leu Ser His Asp Met Ala Thr Val Met
215 220 225
gat gaa gtc ctg gca agc ctt ggt gca ccc gta gca atg gct gga tta 835
Asp Glu Val Leu Ala Ser Leu Gly Ala Pro Val Ala Met Ala Gly Leu
230 235 240 245
att att gcc acc att gtc ttc ttg cca gag acc atc acc tcc ttg aaa 883
Ile Ile Ala Thr Ile Val Phe Leu Pro Glu Thr Ile Thr Ser Leu Lys
250 255 260
gct gcg tgg aca gga gag att cag cga gta agc aac ctc gcg cat gga 931
Ala Ala Trp Thr Gly Glu Ile Gln Arg Val Ser Asn Leu Ala His Gly
265 270 275
gcc caa gta tca acg gtg ggg ctg aca atc cca gct gtt cta gtg atc 979
Ala Gln Val Ser Thr Val Gly Leu Thr Ile Pro Ala Val Leu Val Ile
280 285 290
ggc gtg atc aca ggt caa gat gta gtt ttg ggg gag acc ccg atc aac 1027
Gly Val Ile Thr Gly Gln Asp Val Val Leu Gly Glu Thr Pro Ile Asn
295 300 305
ttg ttg ctg ctg gga acc acc att gcg gtg aca gcc att gcg ttt agc 1075
Leu Leu Leu Leu Gly Thr Thr Ile Ala Val Thr Ala Ile Ala Phe Ser
310 315 320 325
tcc aag aaa gtc agt gct gtg cat ggc tcg gtg ctg ctc atg ctt ttc 1123
Ser Lys Lys Val Ser Ala Val His Gly Ser Val Leu Leu Met Leu Phe
330 335 340
ggt gtt tac atg atg agc atg ttc gcc tgatttaggt agcctggtgg 1170
Gly Val Tyr Met Met Ser Met Phe Ala
345 350
gaa 1173
<210> 596
<211> 350
<212> PRT
<213> Corynebacterium glutamicum
<400> 596
Met Pro Phe Ser Trp Leu Lys Pro Ile Asp Tyr Ala Arg Ile Phe Val
1 5 10 15
Gly Trp Ala Ser Ile Phe Ile Ile Pro Leu Ile Thr Leu Pro Ser Ile
20 25 30
Ile Glu Leu Ala Leu Ile Val Ala Val Ile Leu Phe Cys Ala Phe Gly
35 40 45
Val Val Lys Met Ala Glu Arg Leu Ala His Ile Leu Gly Asp Pro Phe
50 55 60
Gly Ser Leu Ile Leu Thr Leu Ser Ile Val Ile Ile Glu Val Ile Leu
65 70 75 80
Ile Cys Ala Val Met Leu Gly Pro Ala Asp Ser Thr Thr Ala Gly Arg
85 90 95
Asp Ser Val Met Ala Val Ser Met Ile Ile Met Gly Leu Val Val Gly
100 105 110
Leu Cys Leu Leu Ile Gly Gly Leu Arg His Gly Ser Met Pro His Asn
115 120 125
Gly Val Gly Thr Pro Thr Tyr Leu Val Leu Ile Ala Thr Phe Ser Val
130 135 140
Ile Ala Phe Ala Val Pro Ala Phe Arg Gly Glu Tyr Ser Thr Gly Gln
145 150 155 160
Ala Leu Val Ile Ser Thr Leu Thr Ala Val Val Tyr Gly Phe Phe Leu
165 170 175
Phe Arg Gln Met Gly Ala Gln Ala Gly Glu Phe Gln Glu Val Glu Val
180 185 190
Ala Glu Lys Ala Asp Asp Ala Ala Lys Trp Glu Val Pro Phe Arg Gly
195 200 205
Leu Ile Leu Ile Ile Thr Val Leu Pro Ile Val Leu Leu Ser His Asp
210 215 220
Met Ala Thr Val Met Asp Glu Val Leu Ala Ser Leu Gly Ala Pro Val
225 230 235 240
Ala Met Ala Gly Leu Ile Ile Ala Thr Ile Val Phe Leu Pro Glu Thr
245 250 255
Ile Thr Ser Leu Lys Ala Ala Trp Thr Gly Glu Ile Gln Arg Val Ser
260 265 270
Asn Leu Ala His Gly Ala Gln Val Ser Thr Val Gly Leu Thr Ile Pro
275 280 285
Ala Val Leu Val Ile Gly Val Ile Thr Gly Gln Asp Val Val Leu Gly
290 295 300
Glu Thr Pro Ile Asn Leu Leu Leu Leu Gly Thr Thr Ile Ala Val Thr
305 310 315 320
Ala Ile Ala Phe Ser Ser Lys Lys Val Ser Ala Val His Gly Ser Val
325 330 335
Leu Leu Met Leu Phe Gly Val Tyr Met Met Ser Met Phe Ala
340 345 350
<210> 597
<211> 1119
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1096)
<223> RXN00466
<400> 597
tttaaaagcg cactaagagc tcgtcaattc tttaaaacaa gctgagaatg tgaataatag 60
gataggttaa cctgattcga ttagaaaacg gagatttgtc gtg caa tcc cgc ctg 115
Val Gln Ser Arg Leu
1 5
tcc aaa atc ctg cgc agt agc gtc gta ggc gtt gct gtc cta gcc ctg 163
Ser Lys Ile Leu Arg Ser Ser Val Val Gly Val Ala Val Leu Ala Leu
10 15 20
tta gct ggg tgt tct aac aat gca gat gac acc gac gct gat tca aca 211
Leu Ala Gly Cys Ser Asn Asn Ala Asp Asp Thr Asp Ala Asp Ser Thr
25 30 35
tcc acg gga aac tcc gct ttt cct gtt tcg att gaa cac gag ttc gga 259
Ser Thr Gly Asn Ser Ala Phe Pro Val Ser Ile Glu His Glu Phe Gly
40 45 50
acc acc aca atc gat gat gta ccc gaa aga gtt gtc acc ctt ggc gtt 307
Thr Thr Thr Ile Asp Asp Val Pro Glu Arg Val Val Thr Leu Gly Val
55 60 65
acc gac gcc gat att gtc ctc gca ttg ggg acc gtc cca gta ggc aac 355
Thr Asp Ala Asp Ile Val Leu Ala Leu Gly Thr Val Pro Val Gly Asn
70 75 80 85
acc gga tac aaa ttc ttc gaa aac gga ttg gga ccg tgg act gat gag 403
Thr Gly Tyr Lys Phe Phe Glu Asn Gly Leu Gly Pro Trp Thr Asp Glu
90 95 100
tta gtg gaa ggc aaa gaa tta aca ctg ctt gac tct gat tcc aca cca 451
Leu Val Glu Gly Lys Glu Leu Thr Leu Leu Asp Ser Asp Ser Thr Pro
105 110 115
gat ctt gaa caa gta gca gcc ctg gag cca gac ctg att att gga gtc 499
Asp Leu Glu Gln Val Ala Ala Leu Glu Pro Asp Leu Ile Ile Gly Val
120 125 130
tct gcg ggg ttt gac gac gtt gta tac gag caa cta tct gat atc gca 547
Ser Ala Gly Phe Asp Asp Val Val Tyr Glu Gln Leu Ser Asp Ile Ala
135 140 145
ccg gtg gtc gcc cgt cca gcg gga aca gct gca tac gca gta gct cgc 595
Pro Val Val Ala Arg Pro Ala Gly Thr Ala Ala Tyr Ala Val Ala Arg
150 155 160 165
gag gaa gct acc aac ctt gtt gcc cgt gcg atg ggg caa tca gaa aaa 643
Glu Glu Ala Thr Asn Leu Val Ala Arg Ala Met Gly Gln Ser Glu Lys
170 175 180
gga caa gag ctc aat gag gaa aca gat gct ctg atc caa gct gcg cgt 691
Gly Gln Glu Leu Asn Glu Glu Thr Asp Ala Leu Ile Gln Ala Ala Arg
185 190 195
gat gaa aat cct tct ttt gac ggt aaa aca gga acc gtc atc ttg cca 739
Asp Glu Asn Pro Ser Phe Asp Gly Lys Thr Gly Thr Val Ile Leu Pro
200 205 210
tac cag ggt aaa tac ggt gcc tac ctg cca ggc gat gca cgg gga caa 787
Tyr Gln Gly Lys Tyr Gly Ala Tyr Leu Pro Gly Asp Ala Arg Gly Gln
215 220 225
ttc ctc gat tca ctt ggc att tcg ctg ccg gaa gca gtt ctt tcg cga 835
Phe Leu Asp Ser Leu Gly Ile Ser Leu Pro Glu Ala Val Leu Ser Arg
230 235 240 245
gac acc ggc gac agc ttc ttt gtc gat gtc ccc gct gaa agc gtc aaa 883
Asp Thr Gly Asp Ser Phe Phe Val Asp Val Pro Ala Glu Ser Val Lys
250 255 260
gac gta gac ggt gat gtt ctc ctc gtg ctt tcc aac gac gaa aat ctg 931
Asp Val Asp Gly Asp Val Leu Leu Val Leu Ser Asn Asp Glu Asn Leu
265 270 275
gat atc aca gca gag aat cca ctg ttt gaa aca ctc aac gtt gtg caa 979
Asp Ile Thr Ala Glu Asn Pro Leu Phe Glu Thr Leu Asn Val Val Gln
280 285 290
aaa gac gca gta att gtg gca aca acc gaa gaa cgc ggg gcg att acc 1027
Lys Asp Ala Val Ile Val Ala Thr Thr Glu Glu Arg Gly Ala Ile Thr
295 300 305
tac aac tca gtg ctg tct gtt cct ttt gcg ttg gaa cat ctc gca cca 1075
Tyr Asn Ser Val Leu Ser Val Pro Phe Ala Leu Glu His Leu Ala Pro
310 315 320 325
cgt att gct gag gct ttg aag taaaactcaa ctactcgagc aca 1119
Arg Ile Ala Glu Ala Leu Lys
330
<210> 598
<211> 332
<212> PRT
<213> Corynebacterium glutamicum
<400> 598
Val Gln Ser Arg Leu Ser Lys Ile Leu Arg Ser Ser Val Val Gly Val
1 5 10 15
Ala Val Leu Ala Leu Leu Ala Gly Cys Ser Asn Asn Ala Asp Asp Thr
20 25 30
Asp Ala Asp Ser Thr Ser Thr Gly Asn Ser Ala Phe Pro Val Ser Ile
35 40 45
Glu His Glu Phe Gly Thr Thr Thr Ile Asp Asp Val Pro Glu Arg Val
50 55 60
Val Thr Leu Gly Val Thr Asp Ala Asp Ile Val Leu Ala Leu Gly Thr
65 70 75 80
Val Pro Val Gly Asn Thr Gly Tyr Lys Phe Phe Glu Asn Gly Leu Gly
85 90 95
Pro Trp Thr Asp Glu Leu Val Glu Gly Lys Glu Leu Thr Leu Leu Asp
100 105 110
Ser Asp Ser Thr Pro Asp Leu Glu Gln Val Ala Ala Leu Glu Pro Asp
115 120 125
Leu Ile Ile Gly Val Ser Ala Gly Phe Asp Asp Val Val Tyr Glu Gln
130 135 140
Leu Ser Asp Ile Ala Pro Val Val Ala Arg Pro Ala Gly Thr Ala Ala
145 150 155 160
Tyr Ala Val Ala Arg Glu Glu Ala Thr Asn Leu Val Ala Arg Ala Met
165 170 175
Gly Gln Ser Glu Lys Gly Gln Glu Leu Asn Glu Glu Thr Asp Ala Leu
180 185 190
Ile Gln Ala Ala Arg Asp Glu Asn Pro Ser Phe Asp Gly Lys Thr Gly
195 200 205
Thr Val Ile Leu Pro Tyr Gln Gly Lys Tyr Gly Ala Tyr Leu Pro Gly
210 215 220
Asp Ala Arg Gly Gln Phe Leu Asp Ser Leu Gly Ile Ser Leu Pro Glu
225 230 235 240
Ala Val Leu Ser Arg Asp Thr Gly Asp Ser Phe Phe Val Asp Val Pro
245 250 255
Ala Glu Ser Val Lys Asp Val Asp Gly Asp Val Leu Leu Val Leu Ser
260 265 270
Asn Asp Glu Asn Leu Asp Ile Thr Ala Glu Asn Pro Leu Phe Glu Thr
275 280 285
Leu Asn Val Val Gln Lys Asp Ala Val Ile Val Ala Thr Thr Glu Glu
290 295 300
Arg Gly Ala Ile Thr Tyr Asn Ser Val Leu Ser Val Pro Phe Ala Leu
305 310 315 320
Glu His Leu Ala Pro Arg Ile Ala Glu Ala Leu Lys
325 330
<210> 599
<211> 1395
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1372)
<223> RXN01936
<400> 599
gcgcggtgac accacagccg ttgtcagcgg cgcttggtct gtggaggatc gccgaggtta 60
ctaacaaata ggcccaacaa agaggtctaa gctctacctg gtg agt ttc cga gat 115
Val Ser Phe Arg Asp
1 5
att ttc gct gac acc aga ccg ctg aaa gaa ccg gcc ttc aaa cgc ctc 163
Ile Phe Ala Asp Thr Arg Pro Leu Lys Glu Pro Ala Phe Lys Arg Leu
10 15 20
tgg ctt ggc aat gtt gcc acc gtc att ggt gcc caa tta act gtt gtt 211
Trp Leu Gly Asn Val Ala Thr Val Ile Gly Ala Gln Leu Thr Val Val
25 30 35
gcc gtt ccg gtg cag att tac caa atg act ggg tcc tcc ggc tat gtg 259
Ala Val Pro Val Gln Ile Tyr Gln Met Thr Gly Ser Ser Gly Tyr Val
40 45 50
ggc ttg acc ggg ctt ttt ggc ctt att cct ttg gtt att ttt ggc ctt 307
Gly Leu Thr Gly Leu Phe Gly Leu Ile Pro Leu Val Ile Phe Gly Leu
55 60 65
tat ggt gga tcc att gcg gat gct ttt gat aaa cgc atc gtg ctg atc 355
Tyr Gly Gly Ser Ile Ala Asp Ala Phe Asp Lys Arg Ile Val Leu Ile
70 75 80 85
tgc acc acg atc ggc atg tgt gtc acc act gcc ggt ttt tgg gtg ctg 403
Cys Thr Thr Ile Gly Met Cys Val Thr Thr Ala Gly Phe Trp Val Leu
90 95 100
acc att tta ggc aat gag aat att tgg ctc ctg tta ata aac ttt tct 451
Thr Ile Leu Gly Asn Glu Asn Ile Trp Leu Leu Leu Ile Asn Phe Ser
105 110 115
tta cag cag gca ttt ttc gcg gtg aat caa ccc acc cga acg gcg atc 499
Leu Gln Gln Ala Phe Phe Ala Val Asn Gln Pro Thr Arg Thr Ala Ile
120 125 130
ctt cga agt att ttg ccg att gat caa tta gcg tcg gca aca tca ctg 547
Leu Arg Ser Ile Leu Pro Ile Asp Gln Leu Ala Ser Ala Thr Ser Leu
135 140 145
aat atg ctg ctc atg cag acc ggc gca atc gtt ggc ccg ctg atc gca 595
Asn Met Leu Leu Met Gln Thr Gly Ala Ile Val Gly Pro Leu Ile Ala
150 155 160 165
ggt gcg ttg att ccg ctg atc ggt ttc ggg tgg ctg tat ttc ctt gat 643
Gly Ala Leu Ile Pro Leu Ile Gly Phe Gly Trp Leu Tyr Phe Leu Asp
170 175 180
gtt gtc tcc atc atc ccc aca ctg tgg gct gta tgg tca ctg cct tcg 691
Val Val Ser Ile Ile Pro Thr Leu Trp Ala Val Trp Ser Leu Pro Ser
185 190 195
atc aag cca tcc ggc aag gtg atg aag gct ggt ttc gcc agt gtg gtg 739
Ile Lys Pro Ser Gly Lys Val Met Lys Ala Gly Phe Ala Ser Val Val
200 205 210
gat ggc ctg aag tat ttg gct ggc caa ccc gtg ttg ttg atg gtg atg 787
Asp Gly Leu Lys Tyr Leu Ala Gly Gln Pro Val Leu Leu Met Val Met
215 220 225
gtg ctg gat ctt atc gcc atg att ttc ggc atg cca cgt gcg ctt tac 835
Val Leu Asp Leu Ile Ala Met Ile Phe Gly Met Pro Arg Ala Leu Tyr
230 235 240 245
ccc gag atc gca gaa gtg aac ttc ggt ggg ggt gac gcc ggt gca acg 883
Pro Glu Ile Ala Glu Val Asn Phe Gly Gly Gly Asp Ala Gly Ala Thr
250 255 260
atg ctg gcg ttc atg tac tca tcc atg gct gtt ggc gca gtt ctt ggc 931
Met Leu Ala Phe Met Tyr Ser Ser Met Ala Val Gly Ala Val Leu Gly
265 270 275
ggc gtg ctg tct ggt tgg gtg gcc cgg att agc cgc cag ggt gtt gca 979
Gly Val Leu Ser Gly Trp Val Ala Arg Ile Ser Arg Gln Gly Val Ala
280 285 290
gtt tat tgg tgc atc atc gcc tgg ggc gca gcc gtt gct ttg ggt ggt 1027
Val Tyr Trp Cys Ile Ile Ala Trp Gly Ala Ala Val Ala Leu Gly Gly
295 300 305
gtg gca att gtt gtc agc ccc ggc gcg gtg act gcg tgg gcg tgg atg 1075
Val Ala Ile Val Val Ser Pro Gly Ala Val Thr Ala Trp Ala Trp Met
310 315 320 325
ttc atc atc atg atg gtc att ggt ggc atg gct gac atg ttc agc tcg 1123
Phe Ile Ile Met Met Val Ile Gly Gly Met Ala Asp Met Phe Ser Ser
330 335 340
gca gtt cga aac gct att ttg cag cag tct gct gcg gaa cat gtg cag 1171
Ala Val Arg Asn Ala Ile Leu Gln Gln Ser Ala Ala Glu His Val Gln
345 350 355
ggc cga atc caa ggt gtg tgg atc atc gtc gtg gtg ggt gga cct cgt 1219
Gly Arg Ile Gln Gly Val Trp Ile Ile Val Val Val Gly Gly Pro Arg
360 365 370
tta gct gac gtc ctt cac ggt tgg gcc gct gag ccc ctc ggc gca ggt 1267
Leu Ala Asp Val Leu His Gly Trp Ala Ala Glu Pro Leu Gly Ala Gly
375 380 385
tgg acg gta tta tgg ggc gga gta gcg gtg gtt gta ctc act gca att 1315
Trp Thr Val Leu Trp Gly Gly Val Ala Val Val Val Leu Thr Ala Ile
390 395 400 405
tgt atg gtg gcg gtg cct aaa ttc tgg aaa tac gag aaa cca aaa att 1363
Cys Met Val Ala Val Pro Lys Phe Trp Lys Tyr Glu Lys Pro Lys Ile
410 415 420
acc ggc atc taaatactta tccatgccca ttt 1395
Thr Gly Ile
<210> 600
<211> 424
<212> PRT
<213> Corynebacterium glutamicum
<400> 600
Val Ser Phe Arg Asp Ile Phe Ala Asp Thr Arg Pro Leu Lys Glu Pro
1 5 10 15
Ala Phe Lys Arg Leu Trp Leu Gly Asn Val Ala Thr Val Ile Gly Ala
20 25 30
Gln Leu Thr Val Val Ala Val Pro Val Gln Ile Tyr Gln Met Thr Gly
35 40 45
Ser Ser Gly Tyr Val Gly Leu Thr Gly Leu Phe Gly Leu Ile Pro Leu
50 55 60
Val Ile Phe Gly Leu Tyr Gly Gly Ser Ile Ala Asp Ala Phe Asp Lys
65 70 75 80
Arg Ile Val Leu Ile Cys Thr Thr Ile Gly Met Cys Val Thr Thr Ala
85 90 95
Gly Phe Trp Val Leu Thr Ile Leu Gly Asn Glu Asn Ile Trp Leu Leu
100 105 110
Leu Ile Asn Phe Ser Leu Gln Gln Ala Phe Phe Ala Val Asn Gln Pro
115 120 125
Thr Arg Thr Ala Ile Leu Arg Ser Ile Leu Pro Ile Asp Gln Leu Ala
130 135 140
Ser Ala Thr Ser Leu Asn Met Leu Leu Met Gln Thr Gly Ala Ile Val
145 150 155 160
Gly Pro Leu Ile Ala Gly Ala Leu Ile Pro Leu Ile Gly Phe Gly Trp
165 170 175
Leu Tyr Phe Leu Asp Val Val Ser Ile Ile Pro Thr Leu Trp Ala Val
180 185 190
Trp Ser Leu Pro Ser Ile Lys Pro Ser Gly Lys Val Met Lys Ala Gly
195 200 205
Phe Ala Ser Val Val Asp Gly Leu Lys Tyr Leu Ala Gly Gln Pro Val
210 215 220
Leu Leu Met Val Met Val Leu Asp Leu Ile Ala Met Ile Phe Gly Met
225 230 235 240
Pro Arg Ala Leu Tyr Pro Glu Ile Ala Glu Val Asn Phe Gly Gly Gly
245 250 255
Asp Ala Gly Ala Thr Met Leu Ala Phe Met Tyr Ser Ser Met Ala Val
260 265 270
Gly Ala Val Leu Gly Gly Val Leu Ser Gly Trp Val Ala Arg Ile Ser
275 280 285
Arg Gln Gly Val Ala Val Tyr Trp Cys Ile Ile Ala Trp Gly Ala Ala
290 295 300
Val Ala Leu Gly Gly Val Ala Ile Val Val Ser Pro Gly Ala Val Thr
305 310 315 320
Ala Trp Ala Trp Met Phe Ile Ile Met Met Val Ile Gly Gly Met Ala
325 330 335
Asp Met Phe Ser Ser Ala Val Arg Asn Ala Ile Leu Gln Gln Ser Ala
340 345 350
Ala Glu His Val Gln Gly Arg Ile Gln Gly Val Trp Ile Ile Val Val
355 360 365
Val Gly Gly Pro Arg Leu Ala Asp Val Leu His Gly Trp Ala Ala Glu
370 375 380
Pro Leu Gly Ala Gly Trp Thr Val Leu Trp Gly Gly Val Ala Val Val
385 390 395 400
Val Leu Thr Ala Ile Cys Met Val Ala Val Pro Lys Phe Trp Lys Tyr
405 410 415
Glu Lys Pro Lys Ile Thr Gly Ile
420
<210> 601
<211> 1461
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1438)
<223> RXN01995
<400> 601
ccgacgcaaa ggcatgcgcc tgcgtgtctc gagtagtctc ctccccttcc tcgtccccaa 60
cctcgaccat tacggtcgcc ctctcctaaa ggagcctggc atg gat atc cgc caa 115
Met Asp Ile Arg Gln
1 5
aca att aac gac aca gca atg tcg aga tat cag tgg ttc att gta ttt 163
Thr Ile Asn Asp Thr Ala Met Ser Arg Tyr Gln Trp Phe Ile Val Phe
10 15 20
atc gca gtg ctg ctc aac gca ctg gac ggc ttt gat gtc ctc gcc atg 211
Ile Ala Val Leu Leu Asn Ala Leu Asp Gly Phe Asp Val Leu Ala Met
25 30 35
tct ttt act gcg aat gca gtg acc gaa gaa ttt gga ctg agt ggc agc 259
Ser Phe Thr Ala Asn Ala Val Thr Glu Glu Phe Gly Leu Ser Gly Ser
40 45 50
cag ctt ggt gtg ctg ctg agt tcc gcg ctg ttc ggc atg acc gct gga 307
Gln Leu Gly Val Leu Leu Ser Ser Ala Leu Phe Gly Met Thr Ala Gly
55 60 65
tct ttg ctg ttc ggt ccg atc ggt gac cgt ttc ggc cgt aag aat gcc 355
Ser Leu Leu Phe Gly Pro Ile Gly Asp Arg Phe Gly Arg Lys Asn Ala
70 75 80 85
ctg atg atc gcg ctg ctg ttc aac gtg gtg gga ttg gta ttg tcc gcc 403
Leu Met Ile Ala Leu Leu Phe Asn Val Val Gly Leu Val Leu Ser Ala
90 95 100
acc gcg cag tcc gca ggc cag ttg ggc gtg tgg cgt ttg atc act ggt 451
Thr Ala Gln Ser Ala Gly Gln Leu Gly Val Trp Arg Leu Ile Thr Gly
105 110 115
atc ggc atc ggc gga atc ctc gcc tgc atc aca gtg gtg atc agt gag 499
Ile Gly Ile Gly Gly Ile Leu Ala Cys Ile Thr Val Val Ile Ser Glu
120 125 130
ttc tcc aac aac aaa aac cgc ggc atg gcc atg tcc atc tac gct gct 547
Phe Ser Asn Asn Lys Asn Arg Gly Met Ala Met Ser Ile Tyr Ala Ala
135 140 145
ggt tac ggc atc ggc gcg tcc ttg ggc ggt ttc ggc gca gcg cag ctc 595
Gly Tyr Gly Ile Gly Ala Ser Leu Gly Gly Phe Gly Ala Ala Gln Leu
150 155 160 165
atc cca aca ttt gga tgg cgc tcc gtg ttc gca gcc ggt gcg atc gca 643
Ile Pro Thr Phe Gly Trp Arg Ser Val Phe Ala Ala Gly Ala Ile Ala
170 175 180
act ggt atc gcc acc atc gct act ttc ttc ttc ctg cca gaa tcc gtt 691
Thr Gly Ile Ala Thr Ile Ala Thr Phe Phe Phe Leu Pro Glu Ser Val
185 190 195
gat tgg ctg agc act cgc cgc cct gcg ggc gct cgc gac aag atc aat 739
Asp Trp Leu Ser Thr Arg Arg Pro Ala Gly Ala Arg Asp Lys Ile Asn
200 205 210
tac att gcg cgc cgc ctg ggc aaa gtc ggt acc ttt gag ctt cca ggc 787
Tyr Ile Ala Arg Arg Leu Gly Lys Val Gly Thr Phe Glu Leu Pro Gly
215 220 225
gaa caa agc ttg tcg acg aaa aaa gcc ggt ctc caa tcg tat gca gtg 835
Glu Gln Ser Leu Ser Thr Lys Lys Ala Gly Leu Gln Ser Tyr Ala Val
230 235 240 245
ctc gtt aac aaa gag aac cgt gga acc agc atc aag ctg tgg gtt gcg 883
Leu Val Asn Lys Glu Asn Arg Gly Thr Ser Ile Lys Leu Trp Val Ala
250 255 260
ttc ggc atc gtg atg ttc ggc ttc tac ttc gcc aac act tgg acc ccg 931
Phe Gly Ile Val Met Phe Gly Phe Tyr Phe Ala Asn Thr Trp Thr Pro
265 270 275
aag ctg ctc gtg gaa acc gga atg tca gaa cag cag ggc atc atc ggt 979
Lys Leu Leu Val Glu Thr Gly Met Ser Glu Gln Gln Gly Ile Ile Gly
280 285 290
ggt ttg atg ttg tcc atg ggt gga gca ttc ggc tcc ctg ctc tac ggt 1027
Gly Leu Met Leu Ser Met Gly Gly Ala Phe Gly Ser Leu Leu Tyr Gly
295 300 305
ttc ctc acc acc aag ttc agc tcc cga aac aca ctg atg acc ttc atg 1075
Phe Leu Thr Thr Lys Phe Ser Ser Arg Asn Thr Leu Met Thr Phe Met
310 315 320 325
gtg ctg tcc ggc ctg acg ctg atc ctg ttc att tcc tcc acc tct gtt 1123
Val Leu Ser Gly Leu Thr Leu Ile Leu Phe Ile Ser Ser Thr Ser Val
330 335 340
cca tcc atc gcg ttt gcc agc ggc gtt gtc gtg ggc atg ctg atc aat 1171
Pro Ser Ile Ala Phe Ala Ser Gly Val Val Val Gly Met Leu Ile Asn
345 350 355
ggt tgt gtg gct ggt ctg tac acc ctg tcc cca cag ctg tac tcc gct 1219
Gly Cys Val Ala Gly Leu Tyr Thr Leu Ser Pro Gln Leu Tyr Ser Ala
360 365 370
gaa gta cgc acc act ggt gtg ggc gct gcg att ggt atg ggt cgt gtc 1267
Glu Val Arg Thr Thr Gly Val Gly Ala Ala Ile Gly Met Gly Arg Val
375 380 385
ggt gcg att tcc gcg cca ctg ctg gtg ggt ggc ctg ctg gat tct ggc 1315
Gly Ala Ile Ser Ala Pro Leu Leu Val Gly Gly Leu Leu Asp Ser Gly
390 395 400 405
tgg tcc cca acg cag ctg tat gtt ggt gtg gca gtg att gtt att gcc 1363
Trp Ser Pro Thr Gln Leu Tyr Val Gly Val Ala Val Ile Val Ile Ala
410 415 420
ggt gca acc gca ttg att ggg atg cgc act cag gcg gta gcc gtc gaa 1411
Gly Ala Thr Ala Leu Ile Gly Met Arg Thr Gln Ala Val Ala Val Glu
425 430 435
aag cag cct gaa gcc cta gcg acc aaa tagggccgcg attcctagca 1458
Lys Gln Pro Glu Ala Leu Ala Thr Lys
440 445
tgc 1461
<210> 602
<211> 446
<212> PRT
<213> Corynebacterium glutamicum
<400> 602
Met Asp Ile Arg Gln Thr Ile Asn Asp Thr Ala Met Ser Arg Tyr Gln
1 5 10 15
Trp Phe Ile Val Phe Ile Ala Val Leu Leu Asn Ala Leu Asp Gly Phe
20 25 30
Asp Val Leu Ala Met Ser Phe Thr Ala Asn Ala Val Thr Glu Glu Phe
35 40 45
Gly Leu Ser Gly Ser Gln Leu Gly Val Leu Leu Ser Ser Ala Leu Phe
50 55 60
Gly Met Thr Ala Gly Ser Leu Leu Phe Gly Pro Ile Gly Asp Arg Phe
65 70 75 80
Gly Arg Lys Asn Ala Leu Met Ile Ala Leu Leu Phe Asn Val Val Gly
85 90 95
Leu Val Leu Ser Ala Thr Ala Gln Ser Ala Gly Gln Leu Gly Val Trp
100 105 110
Arg Leu Ile Thr Gly Ile Gly Ile Gly Gly Ile Leu Ala Cys Ile Thr
115 120 125
Val Val Ile Ser Glu Phe Ser Asn Asn Lys Asn Arg Gly Met Ala Met
130 135 140
Ser Ile Tyr Ala Ala Gly Tyr Gly Ile Gly Ala Ser Leu Gly Gly Phe
145 150 155 160
Gly Ala Ala Gln Leu Ile Pro Thr Phe Gly Trp Arg Ser Val Phe Ala
165 170 175
Ala Gly Ala Ile Ala Thr Gly Ile Ala Thr Ile Ala Thr Phe Phe Phe
180 185 190
Leu Pro Glu Ser Val Asp Trp Leu Ser Thr Arg Arg Pro Ala Gly Ala
195 200 205
Arg Asp Lys Ile Asn Tyr Ile Ala Arg Arg Leu Gly Lys Val Gly Thr
210 215 220
Phe Glu Leu Pro Gly Glu Gln Ser Leu Ser Thr Lys Lys Ala Gly Leu
225 230 235 240
Gln Ser Tyr Ala Val Leu Val Asn Lys Glu Asn Arg Gly Thr Ser Ile
245 250 255
Lys Leu Trp Val Ala Phe Gly Ile Val Met Phe Gly Phe Tyr Phe Ala
260 265 270
Asn Thr Trp Thr Pro Lys Leu Leu Val Glu Thr Gly Met Ser Glu Gln
275 280 285
Gln Gly Ile Ile Gly Gly Leu Met Leu Ser Met Gly Gly Ala Phe Gly
290 295 300
Ser Leu Leu Tyr Gly Phe Leu Thr Thr Lys Phe Ser Ser Arg Asn Thr
305 310 315 320
Leu Met Thr Phe Met Val Leu Ser Gly Leu Thr Leu Ile Leu Phe Ile
325 330 335
Ser Ser Thr Ser Val Pro Ser Ile Ala Phe Ala Ser Gly Val Val Val
340 345 350
Gly Met Leu Ile Asn Gly Cys Val Ala Gly Leu Tyr Thr Leu Ser Pro
355 360 365
Gln Leu Tyr Ser Ala Glu Val Arg Thr Thr Gly Val Gly Ala Ala Ile
370 375 380
Gly Met Gly Arg Val Gly Ala Ile Ser Ala Pro Leu Leu Val Gly Gly
385 390 395 400
Leu Leu Asp Ser Gly Trp Ser Pro Thr Gln Leu Tyr Val Gly Val Ala
405 410 415
Val Ile Val Ile Ala Gly Ala Thr Ala Leu Ile Gly Met Arg Thr Gln
420 425 430
Ala Val Ala Val Glu Lys Gln Pro Glu Ala Leu Ala Thr Lys
435 440 445
<210> 603
<211> 813
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(790)
<223> RXN00661
<400> 603
cggatgcaag agaaccgtgg tttcgctgat ttttggcgaa cccggaatta aggccccgag 60
gattacatgc ttttaaatcc tttgaaaagg ggacaagatc atg aat cct ata acc 115
Met Asn Pro Ile Thr
1 5
gaa tta tta gac gca aca cta tgg atc ggc gga gtt ccg att ctg tgg 163
Glu Leu Leu Asp Ala Thr Leu Trp Ile Gly Gly Val Pro Ile Leu Trp
10 15 20
cgc gaa atc atc ggc aac gtt ttc gga tta ttt agc gcg tgg gca gga 211
Arg Glu Ile Ile Gly Asn Val Phe Gly Leu Phe Ser Ala Trp Ala Gly
25 30 35
atg cga cgc atc gtg tgg gca tgg ccc atc ggc atc ata ggc aac gcg 259
Met Arg Arg Ile Val Trp Ala Trp Pro Ile Gly Ile Ile Gly Asn Ala
40 45 50
ctg ctg ttc aca gta ttt atg ggc ggc ctt ttc cac act cca caa aac 307
Leu Leu Phe Thr Val Phe Met Gly Gly Leu Phe His Thr Pro Gln Asn
55 60 65
ctc gat ctc tac ggc caa gcg ggt cgc cag atc atg ttc atc atc gtc 355
Leu Asp Leu Tyr Gly Gln Ala Gly Arg Gln Ile Met Phe Ile Ile Val
70 75 80 85
agt ggt tat ggc tgg tac caa tgg tcg gcc gca aaa cgt cgc gca ctc 403
Ser Gly Tyr Gly Trp Tyr Gln Trp Ser Ala Ala Lys Arg Arg Ala Leu
90 95 100
acc cca gaa aat gca gta gca gtg gtt cct cgc tgg gca agc acc aaa 451
Thr Pro Glu Asn Ala Val Ala Val Val Pro Arg Trp Ala Ser Thr Lys
105 110 115
gaa cgc gcc ggc att gtg att gcg gcg gtt gtg gga aca ctc agc ttt 499
Glu Arg Ala Gly Ile Val Ile Ala Ala Val Val Gly Thr Leu Ser Phe
120 125 130
gcc tgg att ttc caa gca ctc ggc tcc tgg ggg cca tgg gcc gac gcg 547
Ala Trp Ile Phe Gln Ala Leu Gly Ser Trp Gly Pro Trp Ala Asp Ala
135 140 145
tgg att ttc gtc ggc tca atc ctg gct acc tac gga atg gct cgc gga 595
Trp Ile Phe Val Gly Ser Ile Leu Ala Thr Tyr Gly Met Ala Arg Gly
150 155 160 165
tgg aca gag ttc tgg ctg atc tgg atc gcc gtc gac ata gtt ggc gtt 643
Trp Thr Glu Phe Trp Leu Ile Trp Ile Ala Val Asp Ile Val Gly Val
170 175 180
cct cta ctt ttg act gct ggc tac tac cca tcc gcg gtg ctt tac ctg 691
Pro Leu Leu Leu Thr Ala Gly Tyr Tyr Pro Ser Ala Val Leu Tyr Leu
185 190 195
gtg tac ggt gcg ttt gtc agc tgg gga ttt gtc gtg tgg ctg cgg gtg 739
Val Tyr Gly Ala Phe Val Ser Trp Gly Phe Val Val Trp Leu Arg Val
200 205 210
caa aaa gca gac aag gct cgt gcg ctg gaa gct cag gag tct gtg aca 787
Gln Lys Ala Asp Lys Ala Arg Ala Leu Glu Ala Gln Glu Ser Val Thr
215 220 225
gtc tgaaaagcgt ttactaaata gaa 813
Val
230
<210> 604
<211> 230
<212> PRT
<213> Corynebacterium glutamicum
<400> 604
Met Asn Pro Ile Thr Glu Leu Leu Asp Ala Thr Leu Trp Ile Gly Gly
1 5 10 15
Val Pro Ile Leu Trp Arg Glu Ile Ile Gly Asn Val Phe Gly Leu Phe
20 25 30
Ser Ala Trp Ala Gly Met Arg Arg Ile Val Trp Ala Trp Pro Ile Gly
35 40 45
Ile Ile Gly Asn Ala Leu Leu Phe Thr Val Phe Met Gly Gly Leu Phe
50 55 60
His Thr Pro Gln Asn Leu Asp Leu Tyr Gly Gln Ala Gly Arg Gln Ile
65 70 75 80
Met Phe Ile Ile Val Ser Gly Tyr Gly Trp Tyr Gln Trp Ser Ala Ala
85 90 95
Lys Arg Arg Ala Leu Thr Pro Glu Asn Ala Val Ala Val Val Pro Arg
100 105 110
Trp Ala Ser Thr Lys Glu Arg Ala Gly Ile Val Ile Ala Ala Val Val
115 120 125
Gly Thr Leu Ser Phe Ala Trp Ile Phe Gln Ala Leu Gly Ser Trp Gly
130 135 140
Pro Trp Ala Asp Ala Trp Ile Phe Val Gly Ser Ile Leu Ala Thr Tyr
145 150 155 160
Gly Met Ala Arg Gly Trp Thr Glu Phe Trp Leu Ile Trp Ile Ala Val
165 170 175
Asp Ile Val Gly Val Pro Leu Leu Leu Thr Ala Gly Tyr Tyr Pro Ser
180 185 190
Ala Val Leu Tyr Leu Val Tyr Gly Ala Phe Val Ser Trp Gly Phe Val
195 200 205
Val Trp Leu Arg Val Gln Lys Ala Asp Lys Ala Arg Ala Leu Glu Ala
210 215 220
Gln Glu Ser Val Thr Val
225 230
<210> 605
<211> 1332
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1309)
<223> RXN02566
<400> 605
gactccggat gatcaagcag cgaaaccttt gtcaagaaca tagctcccca ccctagacaa 60
aagcccaaat aaatctgctc aataacctaa cctaaagtcc atg cac gcc tcg tcg 115
Met His Ala Ser Ser
1 5
ccc caa cct cac cct cag cgc acc cgt gtt ctc agc ggc ctg att ttc 163
Pro Gln Pro His Pro Gln Arg Thr Arg Val Leu Ser Gly Leu Ile Phe
10 15 20
gcc caa atc atg gtt ggt gca tcc aat ggc gtg acg cta tcg atg gga 211
Ala Gln Ile Met Val Gly Ala Ser Asn Gly Val Thr Leu Ser Met Gly
25 30 35
agt ttg ctg gca gca cac ttg gcg gga gct tcg tgg gga gga tca gcc 259
Ser Leu Leu Ala Ala His Leu Ala Gly Ala Ser Trp Gly Gly Ser Ala
40 45 50
gcc aca ttg acc acg atc ggc gca gct atc ttt tcg att ccc ctt gcc 307
Ala Thr Leu Thr Thr Ile Gly Ala Ala Ile Phe Ser Ile Pro Leu Ala
55 60 65
cgc atg gtc tcc aca tac gat cgc cga act tca ctc agc acg ggc atg 355
Arg Met Val Ser Thr Tyr Asp Arg Arg Thr Ser Leu Ser Thr Gly Met
70 75 80 85
ttg ctt ggt tgc gtg ggc gca cta ctg gcg atc ctc ggc gca caa ttc 403
Leu Leu Gly Cys Val Gly Ala Leu Leu Ala Ile Leu Gly Ala Gln Phe
90 95 100
ggc ttg ttt cca gta gta ctt ttg gca ttt ttg ttc ctc gga tcc atg 451
Gly Leu Phe Pro Val Val Leu Leu Ala Phe Leu Phe Leu Gly Ser Met
105 110 115
tcg gcg gtt aac ctc caa gca cgt ttc gcc gca acc gac gtg gcc agt 499
Ser Ala Val Asn Leu Gln Ala Arg Phe Ala Ala Thr Asp Val Ala Ser
120 125 130
gaa gaa acc cgc ggc cgc gac ctc tcg atc gtt gtg tgg tcc acc acc 547
Glu Glu Thr Arg Gly Arg Asp Leu Ser Ile Val Val Trp Ser Thr Thr
135 140 145
atc ggc gca atc gcc gga cca aat tta ttt gaa cca agc gcc cga ttc 595
Ile Gly Ala Ile Ala Gly Pro Asn Leu Phe Glu Pro Ser Ala Arg Phe
150 155 160 165
agc gaa acc ctg ggc ctc gaa caa cat gcc ggc gca tac ctg ctg tgt 643
Ser Glu Thr Leu Gly Leu Glu Gln His Ala Gly Ala Tyr Leu Leu Cys
170 175 180
tta ttt ggc cag ctc atc gcc atc gca gtc tgg cga ttc acc ctc ccc 691
Leu Phe Gly Gln Leu Ile Ala Ile Ala Val Trp Arg Phe Thr Leu Pro
185 190 195
aaa ggc ctc aaa ccc gaa gcc acc cca aat gca cca aca gaa aag aag 739
Lys Gly Leu Lys Pro Glu Ala Thr Pro Asn Ala Pro Thr Glu Lys Lys
200 205 210
cgc ctc acc ccg aaa gcc ctc caa gcc atc aca tcg gtt gca acc gca 787
Arg Leu Thr Pro Lys Ala Leu Gln Ala Ile Thr Ser Val Ala Thr Ala
215 220 225
cac ttc tcc atg gtc ggt ctc atg tcc atg gcc gcc atc cac atg caa 835
His Phe Ser Met Val Gly Leu Met Ser Met Ala Ala Ile His Met Gln
230 235 240 245
ggc cac ggc gcc agc ctc acc atc atc ggc ttc acc atc agt ttg cac 883
Gly His Gly Ala Ser Leu Thr Ile Ile Gly Phe Thr Ile Ser Leu His
250 255 260
gtc gcc gga atg tac gca ctc tca cca gtg ttc ggc ctg ctc aca gac 931
Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe Gly Leu Leu Thr Asp
265 270 275
aaa ctc ggc cgc aat gtc acc atc tat tcc ggc ttc gcc atg ctc gcc 979
Lys Leu Gly Arg Asn Val Thr Ile Tyr Ser Gly Phe Ala Met Leu Ala
280 285 290
aca tcc gca gca ttt ctt atc att tgg ccc gaa cca cag tgg gcc atg 1027
Thr Ser Ala Ala Phe Leu Ile Ile Trp Pro Glu Pro Gln Trp Ala Met
295 300 305
atc aca tcc atg atc ctg ctt ggg ctc ggc tgg aac tct gcc ctc gtc 1075
Ile Thr Ser Met Ile Leu Leu Gly Leu Gly Trp Asn Ser Ala Leu Val
310 315 320 325
ggt tct tca aca ttg ctt gtc gac gcc acc ccc atc cac cac cgc acc 1123
Gly Ser Ser Thr Leu Leu Val Asp Ala Thr Pro Ile His His Arg Thr
330 335 340
tac gcc cag ggg cgc agc gac cta acg atg aat ctt gcg gga gct tca 1171
Tyr Ala Gln Gly Arg Ser Asp Leu Thr Met Asn Leu Ala Gly Ala Ser
345 350 355
ggc ggg ttg atc gcc gga ccg tta att gcc atg ggc gga atg ccc ttg 1219
Gly Gly Leu Ile Ala Gly Pro Leu Ile Ala Met Gly Gly Met Pro Leu
360 365 370
ttg gca ggc gtc gtt ctt gca gtt gtg gcg ctt caa acg gtg ctt agt 1267
Leu Ala Gly Val Val Leu Ala Val Val Ala Leu Gln Thr Val Leu Ser
375 380 385
ttc aga acc cgt tca att gaa aag act cct gct tca tgt ttt 1309
Phe Arg Thr Arg Ser Ile Glu Lys Thr Pro Ala Ser Cys Phe
390 395 400
tagcctagga attcacgcac gac 1332
<210> 606
<211> 403
<212> PRT
<213> Corynebacterium glutamicum
<400> 606
Met His Ala Ser Ser Pro Gln Pro His Pro Gln Arg Thr Arg Val Leu
1 5 10 15
Ser Gly Leu Ile Phe Ala Gln Ile Met Val Gly Ala Ser Asn Gly Val
20 25 30
Thr Leu Ser Met Gly Ser Leu Leu Ala Ala His Leu Ala Gly Ala Ser
35 40 45
Trp Gly Gly Ser Ala Ala Thr Leu Thr Thr Ile Gly Ala Ala Ile Phe
50 55 60
Ser Ile Pro Leu Ala Arg Met Val Ser Thr Tyr Asp Arg Arg Thr Ser
65 70 75 80
Leu Ser Thr Gly Met Leu Leu Gly Cys Val Gly Ala Leu Leu Ala Ile
85 90 95
Leu Gly Ala Gln Phe Gly Leu Phe Pro Val Val Leu Leu Ala Phe Leu
100 105 110
Phe Leu Gly Ser Met Ser Ala Val Asn Leu Gln Ala Arg Phe Ala Ala
115 120 125
Thr Asp Val Ala Ser Glu Glu Thr Arg Gly Arg Asp Leu Ser Ile Val
130 135 140
Val Trp Ser Thr Thr Ile Gly Ala Ile Ala Gly Pro Asn Leu Phe Glu
145 150 155 160
Pro Ser Ala Arg Phe Ser Glu Thr Leu Gly Leu Glu Gln His Ala Gly
165 170 175
Ala Tyr Leu Leu Cys Leu Phe Gly Gln Leu Ile Ala Ile Ala Val Trp
180 185 190
Arg Phe Thr Leu Pro Lys Gly Leu Lys Pro Glu Ala Thr Pro Asn Ala
195 200 205
Pro Thr Glu Lys Lys Arg Leu Thr Pro Lys Ala Leu Gln Ala Ile Thr
210 215 220
Ser Val Ala Thr Ala His Phe Ser Met Val Gly Leu Met Ser Met Ala
225 230 235 240
Ala Ile His Met Gln Gly His Gly Ala Ser Leu Thr Ile Ile Gly Phe
245 250 255
Thr Ile Ser Leu His Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe
260 265 270
Gly Leu Leu Thr Asp Lys Leu Gly Arg Asn Val Thr Ile Tyr Ser Gly
275 280 285
Phe Ala Met Leu Ala Thr Ser Ala Ala Phe Leu Ile Ile Trp Pro Glu
290 295 300
Pro Gln Trp Ala Met Ile Thr Ser Met Ile Leu Leu Gly Leu Gly Trp
305 310 315 320
Asn Ser Ala Leu Val Gly Ser Ser Thr Leu Leu Val Asp Ala Thr Pro
325 330 335
Ile His His Arg Thr Tyr Ala Gln Gly Arg Ser Asp Leu Thr Met Asn
340 345 350
Leu Ala Gly Ala Ser Gly Gly Leu Ile Ala Gly Pro Leu Ile Ala Met
355 360 365
Gly Gly Met Pro Leu Leu Ala Gly Val Val Leu Ala Val Val Ala Leu
370 375 380
Gln Thr Val Leu Ser Phe Arg Thr Arg Ser Ile Glu Lys Thr Pro Ala
385 390 395 400
Ser Cys Phe
<210> 607
<211> 760
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(760)
<223> FRXA02561
<400> 607
atctgctcaa taacctaacc taaagtccat gcacgcctcg tcgccccaac ctcaccctca 60
gcgcacccgt gttctcagcg gcctgatttt cgcccaaatc atg gtt ggt gca tcc 115
Met Val Gly Ala Ser
1 5
aat ggc gtg acg cta tcg atg gga agt ttg ctg gca gca cac ttg gcg 163
Asn Gly Val Thr Leu Ser Met Gly Ser Leu Leu Ala Ala His Leu Ala
10 15 20
gga gct tcg tgg gga gga tca gcc gcc aca ttg acc acg atc ggc gca 211
Gly Ala Ser Trp Gly Gly Ser Ala Ala Thr Leu Thr Thr Ile Gly Ala
25 30 35
gct atc ttt tcg att ccc ctt gcc cgc atg gtc tcc aca tac gat cgc 259
Ala Ile Phe Ser Ile Pro Leu Ala Arg Met Val Ser Thr Tyr Asp Arg
40 45 50
cga act tca ctc agc acg ggc atg ttg ctt ggt tgc gtg ggc gca cta 307
Arg Thr Ser Leu Ser Thr Gly Met Leu Leu Gly Cys Val Gly Ala Leu
55 60 65
ctg gcg atc ctc ggc gca caa ttc ggc ttg ttt cca gta gta ctt ttg 355
Leu Ala Ile Leu Gly Ala Gln Phe Gly Leu Phe Pro Val Val Leu Leu
70 75 80 85
gca ttt ttg ttc ctc gga tcc atg tcg gcg gtt aac ctc caa gca cgt 403
Ala Phe Leu Phe Leu Gly Ser Met Ser Ala Val Asn Leu Gln Ala Arg
90 95 100
ttc gcc gca acc gac gtg gcc agt gaa gaa acc cgc ggc cgc gac ctc 451
Phe Ala Ala Thr Asp Val Ala Ser Glu Glu Thr Arg Gly Arg Asp Leu
105 110 115
tcg atc gtt gtg tgg tcc acc acc atc ggc gca atc gcc gga cca aat 499
Ser Ile Val Val Trp Ser Thr Thr Ile Gly Ala Ile Ala Gly Pro Asn
120 125 130
tta ttt gaa cca agc gcc cga ttc agc gaa acc ctg ggc ctc gaa caa 547
Leu Phe Glu Pro Ser Ala Arg Phe Ser Glu Thr Leu Gly Leu Glu Gln
135 140 145
cat gcc ggc gca tac ctg ctg tgt tta ttt ggc cag ctc atc gcc atc 595
His Ala Gly Ala Tyr Leu Leu Cys Leu Phe Gly Gln Leu Ile Ala Ile
150 155 160 165
gca gtc tgg cga ttc acc ctc ccc aaa ggc ctc aaa ccc gaa gcc acc 643
Ala Val Trp Arg Phe Thr Leu Pro Lys Gly Leu Lys Pro Glu Ala Thr
170 175 180
cca aat gca cca aca gaa aag aag cgc ctc acc ccg aaa gcc ctc caa 691
Pro Asn Ala Pro Thr Glu Lys Lys Arg Leu Thr Pro Lys Ala Leu Gln
185 190 195
gcc atc aca tcg gtt gca acc gca cac ttc tcc atg gtc ggt ctc atg 739
Ala Ile Thr Ser Val Ala Thr Ala His Phe Ser Met Val Gly Leu Met
200 205 210
tcc atg gcc gcc atc cac atg 760
Ser Met Ala Ala Ile His Met
215 220
<210> 608
<211> 220
<212> PRT
<213> Corynebacterium glutamicum
<400> 608
Met Val Gly Ala Ser Asn Gly Val Thr Leu Ser Met Gly Ser Leu Leu
1 5 10 15
Ala Ala His Leu Ala Gly Ala Ser Trp Gly Gly Ser Ala Ala Thr Leu
20 25 30
Thr Thr Ile Gly Ala Ala Ile Phe Ser Ile Pro Leu Ala Arg Met Val
35 40 45
Ser Thr Tyr Asp Arg Arg Thr Ser Leu Ser Thr Gly Met Leu Leu Gly
50 55 60
Cys Val Gly Ala Leu Leu Ala Ile Leu Gly Ala Gln Phe Gly Leu Phe
65 70 75 80
Pro Val Val Leu Leu Ala Phe Leu Phe Leu Gly Ser Met Ser Ala Val
85 90 95
Asn Leu Gln Ala Arg Phe Ala Ala Thr Asp Val Ala Ser Glu Glu Thr
100 105 110
Arg Gly Arg Asp Leu Ser Ile Val Val Trp Ser Thr Thr Ile Gly Ala
115 120 125
Ile Ala Gly Pro Asn Leu Phe Glu Pro Ser Ala Arg Phe Ser Glu Thr
130 135 140
Leu Gly Leu Glu Gln His Ala Gly Ala Tyr Leu Leu Cys Leu Phe Gly
145 150 155 160
Gln Leu Ile Ala Ile Ala Val Trp Arg Phe Thr Leu Pro Lys Gly Leu
165 170 175
Lys Pro Glu Ala Thr Pro Asn Ala Pro Thr Glu Lys Lys Arg Leu Thr
180 185 190
Pro Lys Ala Leu Gln Ala Ile Thr Ser Val Ala Thr Ala His Phe Ser
195 200 205
Met Val Gly Leu Met Ser Met Ala Ala Ile His Met
210 215 220
<210> 609
<211> 461
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(438)
<223> FRXA02566
<400> 609
atc agt ttg cac gtc gcc gga atg tac gca ctc tca cca gtg ttc ggc 48
Ile Ser Leu His Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe Gly
1 5 10 15
ctg ctc aca gac aaa ctc ggc cgc aat gtc acc atc tat tcc ggc ttc 96
Leu Leu Thr Asp Lys Leu Gly Arg Asn Val Thr Ile Tyr Ser Gly Phe
20 25 30
gcc atg ctc gcc aca tcc gca gca ttt ctt atc att tgg ccc gaa cca 144
Ala Met Leu Ala Thr Ser Ala Ala Phe Leu Ile Ile Trp Pro Glu Pro
35 40 45
cag tgg gcc atg atc aca tcc atg atc ctg ctt ggg ctc ggc tgg aac 192
Gln Trp Ala Met Ile Thr Ser Met Ile Leu Leu Gly Leu Gly Trp Asn
50 55 60
tct gcc ctc gtc ggt tct tca aca ttg ctt gtc gac gcc acc ccc atc 240
Ser Ala Leu Val Gly Ser Ser Thr Leu Leu Val Asp Ala Thr Pro Ile
65 70 75 80
cac cac cgc acc tac gcc cag ggg cgc agc gac cta acg atg aat ctt 288
His His Arg Thr Tyr Ala Gln Gly Arg Ser Asp Leu Thr Met Asn Leu
85 90 95
gcg gga gct tca ggc ggg ttg atc gcc gga ccg tta att gcc atg ggc 336
Ala Gly Ala Ser Gly Gly Leu Ile Ala Gly Pro Leu Ile Ala Met Gly
100 105 110
gga atg ccc ttg ttg gca ggc gtc gtt ctt gca gtt gtg gcg ctt caa 384
Gly Met Pro Leu Leu Ala Gly Val Val Leu Ala Val Val Ala Leu Gln
115 120 125
acg gtg ctt agt ttc aga acc cgt tca att gaa aag act cct gct tca 432
Thr Val Leu Ser Phe Arg Thr Arg Ser Ile Glu Lys Thr Pro Ala Ser
130 135 140
tgt ttt tagcctagga attcacgcac gac 461
Cys Phe
145
<210> 610
<211> 146
<212> PRT
<213> Corynebacterium glutamicum
<400> 610
Ile Ser Leu His Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe Gly
1 5 10 15
Leu Leu Thr Asp Lys Leu Gly Arg Asn Val Thr Ile Tyr Ser Gly Phe
20 25 30
Ala Met Leu Ala Thr Ser Ala Ala Phe Leu Ile Ile Trp Pro Glu Pro
35 40 45
Gln Trp Ala Met Ile Thr Ser Met Ile Leu Leu Gly Leu Gly Trp Asn
50 55 60
Ser Ala Leu Val Gly Ser Ser Thr Leu Leu Val Asp Ala Thr Pro Ile
65 70 75 80
His His Arg Thr Tyr Ala Gln Gly Arg Ser Asp Leu Thr Met Asn Leu
85 90 95
Ala Gly Ala Ser Gly Gly Leu Ile Ala Gly Pro Leu Ile Ala Met Gly
100 105 110
Gly Met Pro Leu Leu Ala Gly Val Val Leu Ala Val Val Ala Leu Gln
115 120 125
Thr Val Leu Ser Phe Arg Thr Arg Ser Ile Glu Lys Thr Pro Ala Ser
130 135 140
Cys Phe
145
<210> 611
<211> 1527
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1504)
<223> RXA00051
<400> 611
cagtaaaagt gcaccgacac taagaatcct tatccttcag agtaaggtga tctgcgtcaa 60
aaaatgtccg ctattcaccc gaaacgaggt cagcatctcg atg aat gcc tcc cct 115
Met Asn Ala Ser Pro
1 5
gcc cca acc cga tct ttt aaa gga ttg cgg gct cga cac att cac ttc 163
Ala Pro Thr Arg Ser Phe Lys Gly Leu Arg Ala Arg His Ile His Phe
10 15 20
atc gcg ctg ggt tcc gcg atc ggc acc ggc ttg ttc tac ggt tcc gct 211
Ile Ala Leu Gly Ser Ala Ile Gly Thr Gly Leu Phe Tyr Gly Ser Ala
25 30 35
ggc gca atc caa gca gct ggt cca tct gta ctc ttg gtc tac ctt ctc 259
Gly Ala Ile Gln Ala Ala Gly Pro Ser Val Leu Leu Val Tyr Leu Leu
40 45 50
ggt ggc gcc gtc gtg tac ttc atg ctg cgc gca ctc ggc gag atg gct 307
Gly Gly Ala Val Val Tyr Phe Met Leu Arg Ala Leu Gly Glu Met Ala
55 60 65
gtg cat cac cca gtc cgt ggt tcc ttc gcg gtc tac acc cgc gca cac 355
Val His His Pro Val Arg Gly Ser Phe Ala Val Tyr Thr Arg Ala His
70 75 80 85
ctt ggc gga tgg gca ggc tac atc acc ggc tgg atg ttc gcg ttt gag 403
Leu Gly Gly Trp Ala Gly Tyr Ile Thr Gly Trp Met Phe Ala Phe Glu
90 95 100
atg ctc atc gtc tgc ctg gct gac ctc aca gcc atc ggc atc tat atg 451
Met Leu Ile Val Cys Leu Ala Asp Leu Thr Ala Ile Gly Ile Tyr Met
105 110 115
aac ttc tgg ttc ccc ggc acc cca caa tgg act tgg gtg gta gcc acc 499
Asn Phe Trp Phe Pro Gly Thr Pro Gln Trp Thr Trp Val Val Ala Thr
120 125 130
ctt ctt att gtc ggt ggc gca aac ctc gca tca gtg cgt tgg ttc ggt 547
Leu Leu Ile Val Gly Gly Ala Asn Leu Ala Ser Val Arg Trp Phe Gly
135 140 145
gag ctc gag ttc atc ttc acc atc att aag gtc acc gca gtt gtc gcc 595
Glu Leu Glu Phe Ile Phe Thr Ile Ile Lys Val Thr Ala Val Val Ala
150 155 160 165
atg atc gtc ggc ggc gca gcc atc ctc gca ttc ggt ctc ggc gcc aac 643
Met Ile Val Gly Gly Ala Ala Ile Leu Ala Phe Gly Leu Gly Ala Asn
170 175 180
gct gaa gtt gcc ggc gta tcc aac ctc tgg gag cac ggc gga ttc ttc 691
Ala Glu Val Ala Gly Val Ser Asn Leu Trp Glu His Gly Gly Phe Phe
185 190 195
ccc aac ggt gtt gaa ggc atg atc gca gcc ttc atc ctt gtt ctc ttc 739
Pro Asn Gly Val Glu Gly Met Ile Ala Ala Phe Ile Leu Val Leu Phe
200 205 210
gca ttc ggt ggc acc gaa atc atc ggt gtt gca ggc tct gaa gct gaa 787
Ala Phe Gly Gly Thr Glu Ile Ile Gly Val Ala Gly Ser Glu Ala Glu
215 220 225
gat cct gag aag tcc atc ccc aag gct gtt aat act gtc cca gta cgc 835
Asp Pro Glu Lys Ser Ile Pro Lys Ala Val Asn Thr Val Pro Val Arg
230 235 240 245
atc ctc ctc ttc tat gtg ggt gcc atc ctg gtg atc ctt gcc ctt aat 883
Ile Leu Leu Phe Tyr Val Gly Ala Ile Leu Val Ile Leu Ala Leu Asn
250 255 260
cct tgg cct tcc atc acc ggc gaa gaa tcc cca ttc gtc cag atc ttc 931
Pro Trp Pro Ser Ile Thr Gly Glu Glu Ser Pro Phe Val Gln Ile Phe
265 270 275
gac acc ctc ggc gtc aac tgg gct gct ggt ctc ctc aac gcc gtg gtc 979
Asp Thr Leu Gly Val Asn Trp Ala Ala Gly Leu Leu Asn Ala Val Val
280 285 290
atc acc gct gca ctg tct gcc atc aac gct gac ctc ttc ggc gct ggc 1027
Ile Thr Ala Ala Leu Ser Ala Ile Asn Ala Asp Leu Phe Gly Ala Gly
295 300 305
cgc gtt ctc act ggt ctt gcg aag gaa aac ctc gca cca aag gcc atg 1075
Arg Val Leu Thr Gly Leu Ala Lys Glu Asn Leu Ala Pro Lys Ala Met
310 315 320 325
ggc aag atc gcc aag aac ggc gtt cca gtc atg acc acc acc atc atg 1123
Gly Lys Ile Ala Lys Asn Gly Val Pro Val Met Thr Thr Thr Ile Met
330 335 340
atc atc gtc ttg atc gtg gga gta atc ctc aac gca gtg ctt ccc gag 1171
Ile Ile Val Leu Ile Val Gly Val Ile Leu Asn Ala Val Leu Pro Glu
345 350 355
cgc gtc ttc gag atc gtc gct tcc cta gca acc ttc gcc aca gtt tac 1219
Arg Val Phe Glu Ile Val Ala Ser Leu Ala Thr Phe Ala Thr Val Tyr
360 365 370
gtc tgg ctg atg atc ctg ctc gca cag gtg gga tcc cgc cga aac atg 1267
Val Trp Leu Met Ile Leu Leu Ala Gln Val Gly Ser Arg Arg Asn Met
375 380 385
cct gcc gac gag gtc aag tcc ctg aag ttc cct gtc ccc ttc tac ccc 1315
Pro Ala Asp Glu Val Lys Ser Leu Lys Phe Pro Val Pro Phe Tyr Pro
390 395 400 405
ttc gga caa tac ttc gcg atc cta ttt atc gcc ttc acc ttc ggc atc 1363
Phe Gly Gln Tyr Phe Ala Ile Leu Phe Ile Ala Phe Thr Phe Gly Ile
410 415 420
atg gtc tgg tac gac aac tac cac ctg cca ctc gcc gtc ggc gtt gga 1411
Met Val Trp Tyr Asp Asn Tyr His Leu Pro Leu Ala Val Gly Val Gly
425 430 435
ttc ctt gtc ctg atg aca atc ctt tac tac gcc aca ggc cga cca aag 1459
Phe Leu Val Leu Met Thr Ile Leu Tyr Tyr Ala Thr Gly Arg Pro Lys
440 445 450
gcg atc gct ccg atc gat tat gaa gag cta gat ccg cga cgc gat 1504
Ala Ile Ala Pro Ile Asp Tyr Glu Glu Leu Asp Pro Arg Arg Asp
455 460 465
taatctagac tcgcacgaaa aag 1527
<210> 612
<211> 468
<212> PRT
<213> Corynebacterium glutamicum
<400> 612
Met Asn Ala Ser Pro Ala Pro Thr Arg Ser Phe Lys Gly Leu Arg Ala
1 5 10 15
Arg His Ile His Phe Ile Ala Leu Gly Ser Ala Ile Gly Thr Gly Leu
20 25 30
Phe Tyr Gly Ser Ala Gly Ala Ile Gln Ala Ala Gly Pro Ser Val Leu
35 40 45
Leu Val Tyr Leu Leu Gly Gly Ala Val Val Tyr Phe Met Leu Arg Ala
50 55 60
Leu Gly Glu Met Ala Val His His Pro Val Arg Gly Ser Phe Ala Val
65 70 75 80
Tyr Thr Arg Ala His Leu Gly Gly Trp Ala Gly Tyr Ile Thr Gly Trp
85 90 95
Met Phe Ala Phe Glu Met Leu Ile Val Cys Leu Ala Asp Leu Thr Ala
100 105 110
Ile Gly Ile Tyr Met Asn Phe Trp Phe Pro Gly Thr Pro Gln Trp Thr
115 120 125
Trp Val Val Ala Thr Leu Leu Ile Val Gly Gly Ala Asn Leu Ala Ser
130 135 140
Val Arg Trp Phe Gly Glu Leu Glu Phe Ile Phe Thr Ile Ile Lys Val
145 150 155 160
Thr Ala Val Val Ala Met Ile Val Gly Gly Ala Ala Ile Leu Ala Phe
165 170 175
Gly Leu Gly Ala Asn Ala Glu Val Ala Gly Val Ser Asn Leu Trp Glu
180 185 190
His Gly Gly Phe Phe Pro Asn Gly Val Glu Gly Met Ile Ala Ala Phe
195 200 205
Ile Leu Val Leu Phe Ala Phe Gly Gly Thr Glu Ile Ile Gly Val Ala
210 215 220
Gly Ser Glu Ala Glu Asp Pro Glu Lys Ser Ile Pro Lys Ala Val Asn
225 230 235 240
Thr Val Pro Val Arg Ile Leu Leu Phe Tyr Val Gly Ala Ile Leu Val
245 250 255
Ile Leu Ala Leu Asn Pro Trp Pro Ser Ile Thr Gly Glu Glu Ser Pro
260 265 270
Phe Val Gln Ile Phe Asp Thr Leu Gly Val Asn Trp Ala Ala Gly Leu
275 280 285
Leu Asn Ala Val Val Ile Thr Ala Ala Leu Ser Ala Ile Asn Ala Asp
290 295 300
Leu Phe Gly Ala Gly Arg Val Leu Thr Gly Leu Ala Lys Glu Asn Leu
305 310 315 320
Ala Pro Lys Ala Met Gly Lys Ile Ala Lys Asn Gly Val Pro Val Met
325 330 335
Thr Thr Thr Ile Met Ile Ile Val Leu Ile Val Gly Val Ile Leu Asn
340 345 350
Ala Val Leu Pro Glu Arg Val Phe Glu Ile Val Ala Ser Leu Ala Thr
355 360 365
Phe Ala Thr Val Tyr Val Trp Leu Met Ile Leu Leu Ala Gln Val Gly
370 375 380
Ser Arg Arg Asn Met Pro Ala Asp Glu Val Lys Ser Leu Lys Phe Pro
385 390 395 400
Val Pro Phe Tyr Pro Phe Gly Gln Tyr Phe Ala Ile Leu Phe Ile Ala
405 410 415
Phe Thr Phe Gly Ile Met Val Trp Tyr Asp Asn Tyr His Leu Pro Leu
420 425 430
Ala Val Gly Val Gly Phe Leu Val Leu Met Thr Ile Leu Tyr Tyr Ala
435 440 445
Thr Gly Arg Pro Lys Ala Ile Ala Pro Ile Asp Tyr Glu Glu Leu Asp
450 455 460
Pro Arg Arg Asp
465
<210> 613
<211> 1578
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1555)
<223> RXA01172
<400> 613
taaatttttc tagactaccc agattaagtg agattctttc gtgtcttcga caacttcgac 60
aacttcggcc acccgacaag agccgttgag cccgacgggt gtg ctt gcc tcg ttt 115
Val Leu Ala Ser Phe
1 5
agg ttc gcg ttt agt agc ccg cgg agg ttt cgc acc gag gtt tta gct 163
Arg Phe Ala Phe Ser Ser Pro Arg Arg Phe Arg Thr Glu Val Leu Ala
10 15 20
ggc ctc gtg gtg gcg ctc gcg ctg att ccg gag tcg att gcg ttt tcc 211
Gly Leu Val Val Ala Leu Ala Leu Ile Pro Glu Ser Ile Ala Phe Ser
25 30 35
gta tta gct ggc gtg gat cct aag atg ggt ctt ttt gcg tcg tgc acc 259
Val Leu Ala Gly Val Asp Pro Lys Met Gly Leu Phe Ala Ser Cys Thr
40 45 50
atg gca atg acc att gcg ctt aca ggt gga cgc cct gcg atg att tcc 307
Met Ala Met Thr Ile Ala Leu Thr Gly Gly Arg Pro Ala Met Ile Ser
55 60 65
gcg gcg aca ggc gct gtg gcg ctg gtg att gca ccg gtg gtt cgg gat 355
Ala Ala Thr Gly Ala Val Ala Leu Val Ile Ala Pro Val Val Arg Asp
70 75 80 85
cat ggc gtg gaa tat ttc ctg gcc acg gta att ttg gcg ggc att att 403
His Gly Val Glu Tyr Phe Leu Ala Thr Val Ile Leu Ala Gly Ile Ile
90 95 100
cag att gcg ttg tcg ttg ctg ggt gta gcc aag ctg atg cgg ttc att 451
Gln Ile Ala Leu Ser Leu Leu Gly Val Ala Lys Leu Met Arg Phe Ile
105 110 115
ccg cgt tcc gtt atg ctc gga ttt gtt aat gcg ctg gcg tgc ttg gtg 499
Pro Arg Ser Val Met Leu Gly Phe Val Asn Ala Leu Ala Cys Leu Val
120 125 130
ttt ttt gcg cag ctg ccg cac ctg atc gat gtt ccg tgg atg gtg tat 547
Phe Phe Ala Gln Leu Pro His Leu Ile Asp Val Pro Trp Met Val Tyr
135 140 145
ccg ctg ttc gcg ctg ggt att ggc atc atg ctg ttt tgg ccg aag ctg 595
Pro Leu Phe Ala Leu Gly Ile Gly Ile Met Leu Phe Trp Pro Lys Leu
150 155 160 165
acc tcg gtg att ccg gct ccg ctg att gtt atc gtg gcc ttg act gcg 643
Thr Ser Val Ile Pro Ala Pro Leu Ile Val Ile Val Ala Leu Thr Ala
170 175 180
atc gtg tgg gtt ttc gga atc aac att cca aac gtc tct gac cag ggc 691
Ile Val Trp Val Phe Gly Ile Asn Ile Pro Asn Val Ser Asp Gln Gly
185 190 195
gaa ctc ccc tct tcc cta cca gaa ttc ctc att ccc aac gtt ccg ctt 739
Glu Leu Pro Ser Ser Leu Pro Glu Phe Leu Ile Pro Asn Val Pro Leu
200 205 210
act ctt gag act cta aaa att att ggg ccg tat gcg ctt gga atg tcg 787
Thr Leu Glu Thr Leu Lys Ile Ile Gly Pro Tyr Ala Leu Gly Met Ser
215 220 225
ctt gtt ggg ttg atg gaa tcg ctg ctg acc gcc aag ctg gtc gat gat 835
Leu Val Gly Leu Met Glu Ser Leu Leu Thr Ala Lys Leu Val Asp Asp
230 235 240 245
att acg gag gtt cac tcc aat aaa tcc cgc gaa gct gca ggt cag ggc 883
Ile Thr Glu Val His Ser Asn Lys Ser Arg Glu Ala Ala Gly Gln Gly
250 255 260
atc gca aac att atc acc gcg ttt ttg ggc ggc atg ggt ggc tgc gcg 931
Ile Ala Asn Ile Ile Thr Ala Phe Leu Gly Gly Met Gly Gly Cys Ala
265 270 275
atg atc ggc cag acc atg atc aac gtg aaa aac tca gga gcc cgc act 979
Met Ile Gly Gln Thr Met Ile Asn Val Lys Asn Ser Gly Ala Arg Thr
280 285 290
cgc cta tcc acc ttc ttg gcc ggc ggc ttc ctg ctg ctc ctg gtg gtt 1027
Arg Leu Ser Thr Phe Leu Ala Gly Gly Phe Leu Leu Leu Leu Val Val
295 300 305
ttg ctg ggc gat gtc gtg ggc aaa atc ccc atg gcg gcg ctc gtg gca 1075
Leu Leu Gly Asp Val Val Gly Lys Ile Pro Met Ala Ala Leu Val Ala
310 315 320 325
gtc atg att atc gtc tcc atc gac acc gcc gac tgg cat tcg ctg aac 1123
Val Met Ile Ile Val Ser Ile Asp Thr Ala Asp Trp His Ser Leu Asn
330 335 340
ccg cgc acc ctc aaa ttc atg ccg ctg agt gaa acg atc gtc atg ttt 1171
Pro Arg Thr Leu Lys Phe Met Pro Leu Ser Glu Thr Ile Val Met Phe
345 350 355
ata acg atc atc gcg acc ctc gtc acc gga aac ctg gcg atc ggc gtc 1219
Ile Thr Ile Ile Ala Thr Leu Val Thr Gly Asn Leu Ala Ile Gly Val
360 365 370
atc ctc gga gtg ctc acc gcc atg gtc atg ttt gct cgc cgc gtg gcc 1267
Ile Leu Gly Val Leu Thr Ala Met Val Met Phe Ala Arg Arg Val Ala
375 380 385
cac ctc gtg tct gtg gag cgc acc acc gac aac aac atc agc acc tat 1315
His Leu Val Ser Val Glu Arg Thr Thr Asp Asn Asn Ile Ser Thr Tyr
390 395 400 405
acc gtc aag ggc cag cta ttt tgg gcg tcc tcg aac gat atg gtg tac 1363
Thr Val Lys Gly Gln Leu Phe Trp Ala Ser Ser Asn Asp Met Val Tyr
410 415 420
tcc ttc gac tac tcc gac gag gcc gag cag atc atc atc gat ctc acc 1411
Ser Phe Asp Tyr Ser Asp Glu Ala Glu Gln Ile Ile Ile Asp Leu Thr
425 430 435
gcc gca gaa atc tgg gac gcc tcc acg gta gcc acg ctg gac agc atc 1459
Ala Ala Glu Ile Trp Asp Ala Ser Thr Val Ala Thr Leu Asp Ser Ile
440 445 450
atc cac aaa tac gcc gcg cgc ggc aag agc gtg gag atc atc ggg ctc 1507
Ile His Lys Tyr Ala Ala Arg Gly Lys Ser Val Glu Ile Ile Gly Leu
455 460 465
gac ggc ccc agc cgc gat agg ctt gag cgc cta tca ggc aag ctg ggc 1555
Asp Gly Pro Ser Arg Asp Arg Leu Glu Arg Leu Ser Gly Lys Leu Gly
470 475 480 485
taaaaatttg cttatcgacg cgc 1578
<210> 614
<211> 485
<212> PRT
<213> Corynebacterium glutamicum
<400> 614
Val Leu Ala Ser Phe Arg Phe Ala Phe Ser Ser Pro Arg Arg Phe Arg
1 5 10 15
Thr Glu Val Leu Ala Gly Leu Val Val Ala Leu Ala Leu Ile Pro Glu
20 25 30
Ser Ile Ala Phe Ser Val Leu Ala Gly Val Asp Pro Lys Met Gly Leu
35 40 45
Phe Ala Ser Cys Thr Met Ala Met Thr Ile Ala Leu Thr Gly Gly Arg
50 55 60
Pro Ala Met Ile Ser Ala Ala Thr Gly Ala Val Ala Leu Val Ile Ala
65 70 75 80
Pro Val Val Arg Asp His Gly Val Glu Tyr Phe Leu Ala Thr Val Ile
85 90 95
Leu Ala Gly Ile Ile Gln Ile Ala Leu Ser Leu Leu Gly Val Ala Lys
100 105 110
Leu Met Arg Phe Ile Pro Arg Ser Val Met Leu Gly Phe Val Asn Ala
115 120 125
Leu Ala Cys Leu Val Phe Phe Ala Gln Leu Pro His Leu Ile Asp Val
130 135 140
Pro Trp Met Val Tyr Pro Leu Phe Ala Leu Gly Ile Gly Ile Met Leu
145 150 155 160
Phe Trp Pro Lys Leu Thr Ser Val Ile Pro Ala Pro Leu Ile Val Ile
165 170 175
Val Ala Leu Thr Ala Ile Val Trp Val Phe Gly Ile Asn Ile Pro Asn
180 185 190
Val Ser Asp Gln Gly Glu Leu Pro Ser Ser Leu Pro Glu Phe Leu Ile
195 200 205
Pro Asn Val Pro Leu Thr Leu Glu Thr Leu Lys Ile Ile Gly Pro Tyr
210 215 220
Ala Leu Gly Met Ser Leu Val Gly Leu Met Glu Ser Leu Leu Thr Ala
225 230 235 240
Lys Leu Val Asp Asp Ile Thr Glu Val His Ser Asn Lys Ser Arg Glu
245 250 255
Ala Ala Gly Gln Gly Ile Ala Asn Ile Ile Thr Ala Phe Leu Gly Gly
260 265 270
Met Gly Gly Cys Ala Met Ile Gly Gln Thr Met Ile Asn Val Lys Asn
275 280 285
Ser Gly Ala Arg Thr Arg Leu Ser Thr Phe Leu Ala Gly Gly Phe Leu
290 295 300
Leu Leu Leu Val Val Leu Leu Gly Asp Val Val Gly Lys Ile Pro Met
305 310 315 320
Ala Ala Leu Val Ala Val Met Ile Ile Val Ser Ile Asp Thr Ala Asp
325 330 335
Trp His Ser Leu Asn Pro Arg Thr Leu Lys Phe Met Pro Leu Ser Glu
340 345 350
Thr Ile Val Met Phe Ile Thr Ile Ile Ala Thr Leu Val Thr Gly Asn
355 360 365
Leu Ala Ile Gly Val Ile Leu Gly Val Leu Thr Ala Met Val Met Phe
370 375 380
Ala Arg Arg Val Ala His Leu Val Ser Val Glu Arg Thr Thr Asp Asn
385 390 395 400
Asn Ile Ser Thr Tyr Thr Val Lys Gly Gln Leu Phe Trp Ala Ser Ser
405 410 415
Asn Asp Met Val Tyr Ser Phe Asp Tyr Ser Asp Glu Ala Glu Gln Ile
420 425 430
Ile Ile Asp Leu Thr Ala Ala Glu Ile Trp Asp Ala Ser Thr Val Ala
435 440 445
Thr Leu Asp Ser Ile Ile His Lys Tyr Ala Ala Arg Gly Lys Ser Val
450 455 460
Glu Ile Ile Gly Leu Asp Gly Pro Ser Arg Asp Arg Leu Glu Arg Leu
465 470 475 480
Ser Gly Lys Leu Gly
485
<210> 615
<211> 1818
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1795)
<223> RXA02128
<400> 615
tattagcaaa acttcttaaa gagccttttt gtgcctttat ccgagtatct ttaaaagcat 60
gagtattaag tgggcgcgct ttgtaccggg gataaccgcg atg cgg ggc tat caa 115
Met Arg Gly Tyr Gln
1 5
cga tcc tgg ttg aag ggt gat gtc atc gcg ggt ata acc gtg gcc gcg 163
Arg Ser Trp Leu Lys Gly Asp Val Ile Ala Gly Ile Thr Val Ala Ala
10 15 20
tac ttg gtt cca caa gtc atg gct tat gcc gtc att gcg ggg ctg cca 211
Tyr Leu Val Pro Gln Val Met Ala Tyr Ala Val Ile Ala Gly Leu Pro
25 30 35
gct gtc gtt ggt ctg tgg gga gtt ctg gct ccc atg gcg ctg tac ttt 259
Ala Val Val Gly Leu Trp Gly Val Leu Ala Pro Met Ala Leu Tyr Phe
40 45 50
ttc ttg ggc acg tct cga aat ctc tcg gtt ggt cct gaa tca acc acc 307
Phe Leu Gly Thr Ser Arg Asn Leu Ser Val Gly Pro Glu Ser Thr Thr
55 60 65
gct ctg atg acg gct gca ggt gtg gga gct tta gtc ggg gca gct ggc 355
Ala Leu Met Thr Ala Ala Gly Val Gly Ala Leu Val Gly Ala Ala Gly
70 75 80 85
ggg cct gaa cga tac gca gaa gta gcg gca cta ttg gct att gca gtg 403
Gly Pro Glu Arg Tyr Ala Glu Val Ala Ala Leu Leu Ala Ile Ala Val
90 95 100
ggc att gta tgc gct gtt ggt ttt att ggc cga ttg gga ttt ctt acc 451
Gly Ile Val Cys Ala Val Gly Phe Ile Gly Arg Leu Gly Phe Leu Thr
105 110 115
agg ctg ttg tct cga ccg gtg ctc gtt gga tat ttg atc ggt att gca 499
Arg Leu Leu Ser Arg Pro Val Leu Val Gly Tyr Leu Ile Gly Ile Ala
120 125 130
gtc ttg atg atc gtc agt cag ctg tcc aaa gtc acc cag gtg aat gtg 547
Val Leu Met Ile Val Ser Gln Leu Ser Lys Val Thr Gln Val Asn Val
135 140 145
gag agc ggt cag acg tgg cag gaa ata ata tcg ttt atc aaa gta gct 595
Glu Ser Gly Gln Thr Trp Gln Glu Ile Ile Ser Phe Ile Lys Val Ala
150 155 160 165
ggc cag gca cat att cct aca gtg att ttg gca gtc gtg gtg ttg agc 643
Gly Gln Ala His Ile Pro Thr Val Ile Leu Ala Val Val Val Leu Ser
170 175 180
ttg ctg tat ctg gca aat tgg ttg acg cct aaa ttt ccc agc aca ctc 691
Leu Leu Tyr Leu Ala Asn Trp Leu Thr Pro Lys Phe Pro Ser Thr Leu
185 190 195
atg gtt ctt ctg ctt tcg gca gcc gcg gtg ggg ttt ttt cat ctg gat 739
Met Val Leu Leu Leu Ser Ala Ala Ala Val Gly Phe Phe His Leu Asp
200 205 210
agg ttt ggt ctt gag gtc att ggt gag gtg ccc cgt ggc ctg cct caa 787
Arg Phe Gly Leu Glu Val Ile Gly Glu Val Pro Arg Gly Leu Pro Gln
215 220 225
cca agt att ccc tcg att ggc gat cta gag atc tgg tcg ttg ttg ccc 835
Pro Ser Ile Pro Ser Ile Gly Asp Leu Glu Ile Trp Ser Leu Leu Pro
230 235 240 245
tat gcc gtg ggt att gcc atc gtt ggt ttt tca gac aat gtg ttg act 883
Tyr Ala Val Gly Ile Ala Ile Val Gly Phe Ser Asp Asn Val Leu Thr
250 255 260
gct cgt gca ttc gcg tcg gga aaa gat gag gtg att gat tcc aac cag 931
Ala Arg Ala Phe Ala Ser Gly Lys Asp Glu Val Ile Asp Ser Asn Gln
265 270 275
gag ctg ctc gca ctg gga acc gca aac ctg gcg aat ggg ttc ttc cag 979
Glu Leu Leu Ala Leu Gly Thr Ala Asn Leu Ala Asn Gly Phe Phe Gln
280 285 290
gga ttt cct gtg tca tcg agt ggc tcc cga act gtt ctt gga gac acg 1027
Gly Phe Pro Val Ser Ser Ser Gly Ser Arg Thr Val Leu Gly Asp Thr
295 300 305
gca ggt gct cgc act cag gtg cat tca ctt gtc gtg gtg gcg ctg gtg 1075
Ala Gly Ala Arg Thr Gln Val His Ser Leu Val Val Val Ala Leu Val
310 315 320 325
atc atg gtg ctg ttg ttt gct ggt cct gtg ctc gag tct ttc cca gat 1123
Ile Met Val Leu Leu Phe Ala Gly Pro Val Leu Glu Ser Phe Pro Asp
330 335 340
gcg gca ctt ggc gcc tta gtt att tat gca gca acg cag ttg att gat 1171
Ala Ala Leu Gly Ala Leu Val Ile Tyr Ala Ala Thr Gln Leu Ile Asp
345 350 355
atc gca gag atc aaa agg atc gca cgt ttc cgc aag agc gag ttg gtc 1219
Ile Ala Glu Ile Lys Arg Ile Ala Arg Phe Arg Lys Ser Glu Leu Val
360 365 370
atc aca gcg gct act gct gca tcc gtt gtg gct tct ggc gtg ctc gcg 1267
Ile Thr Ala Ala Thr Ala Ala Ser Val Val Ala Ser Gly Val Leu Ala
375 380 385
ggg atc ggc gtt gcg gtt acg ttg tcc atc ttg gat ctc atc aga cgt 1315
Gly Ile Gly Val Ala Val Thr Leu Ser Ile Leu Asp Leu Ile Arg Arg
390 395 400 405
att acc cga cct tat gcc gat gtc cta gga tat acg ccg ggc atg gct 1363
Ile Thr Arg Pro Tyr Ala Asp Val Leu Gly Tyr Thr Pro Gly Met Ala
410 415 420
gga atg cac agc ttg gag gat tat cct gag tcg aca gca gtc gaa ggg 1411
Gly Met His Ser Leu Glu Asp Tyr Pro Glu Ser Thr Ala Val Glu Gly
425 430 435
ctc gtg gtt ttt aga tac gat tcc cca ctg ttt ttc gcc aac gct gat 1459
Leu Val Val Phe Arg Tyr Asp Ser Pro Leu Phe Phe Ala Asn Ala Asp
440 445 450
gat ttt tcc aaa cgt gcc atc gaa gcc gtt gat gaa gca act caa ccc 1507
Asp Phe Ser Lys Arg Ala Ile Glu Ala Val Asp Glu Ala Thr Gln Pro
455 460 465
gtg cat tgg ttt tta ctg aat gct gaa gcg aat acg gaa gtt gat ctc 1555
Val His Trp Phe Leu Leu Asn Ala Glu Ala Asn Thr Glu Val Asp Leu
470 475 480 485
acg gcc gtc gat gcc atg gaa gca ctt cgc aaa acc ctg gag gaa cgg 1603
Thr Ala Val Asp Ala Met Glu Ala Leu Arg Lys Thr Leu Glu Glu Arg
490 495 500
ggt atc cga ttt gcg atg gcc cgg gtg aag caa gat cta cgc cga agc 1651
Gly Ile Arg Phe Ala Met Ala Arg Val Lys Gln Asp Leu Arg Arg Ser
505 510 515
ctc gag cct gca ggt ttc att gaa tcc gtg ggg gag gag tac att ttc 1699
Leu Glu Pro Ala Gly Phe Ile Glu Ser Val Gly Glu Glu Tyr Ile Phe
520 525 530
gcc aca ctc ccc act gca gtc aag ggg tat tcc gtg gag ttt cgc gat 1747
Ala Thr Leu Pro Thr Ala Val Lys Gly Tyr Ser Val Glu Phe Arg Asp
535 540 545
cgt ttt gga aac tat cca gaa ggc gtt ccg aaa gaa att ttg gaa ctt 1795
Arg Phe Gly Asn Tyr Pro Glu Gly Val Pro Lys Glu Ile Leu Glu Leu
550 555 560 565
taagctgcct ggttggcgga ctt 1818
<210> 616
<211> 565
<212> PRT
<213> Corynebacterium glutamicum
<400> 616
Met Arg Gly Tyr Gln Arg Ser Trp Leu Lys Gly Asp Val Ile Ala Gly
1 5 10 15
Ile Thr Val Ala Ala Tyr Leu Val Pro Gln Val Met Ala Tyr Ala Val
20 25 30
Ile Ala Gly Leu Pro Ala Val Val Gly Leu Trp Gly Val Leu Ala Pro
35 40 45
Met Ala Leu Tyr Phe Phe Leu Gly Thr Ser Arg Asn Leu Ser Val Gly
50 55 60
Pro Glu Ser Thr Thr Ala Leu Met Thr Ala Ala Gly Val Gly Ala Leu
65 70 75 80
Val Gly Ala Ala Gly Gly Pro Glu Arg Tyr Ala Glu Val Ala Ala Leu
85 90 95
Leu Ala Ile Ala Val Gly Ile Val Cys Ala Val Gly Phe Ile Gly Arg
100 105 110
Leu Gly Phe Leu Thr Arg Leu Leu Ser Arg Pro Val Leu Val Gly Tyr
115 120 125
Leu Ile Gly Ile Ala Val Leu Met Ile Val Ser Gln Leu Ser Lys Val
130 135 140
Thr Gln Val Asn Val Glu Ser Gly Gln Thr Trp Gln Glu Ile Ile Ser
145 150 155 160
Phe Ile Lys Val Ala Gly Gln Ala His Ile Pro Thr Val Ile Leu Ala
165 170 175
Val Val Val Leu Ser Leu Leu Tyr Leu Ala Asn Trp Leu Thr Pro Lys
180 185 190
Phe Pro Ser Thr Leu Met Val Leu Leu Leu Ser Ala Ala Ala Val Gly
195 200 205
Phe Phe His Leu Asp Arg Phe Gly Leu Glu Val Ile Gly Glu Val Pro
210 215 220
Arg Gly Leu Pro Gln Pro Ser Ile Pro Ser Ile Gly Asp Leu Glu Ile
225 230 235 240
Trp Ser Leu Leu Pro Tyr Ala Val Gly Ile Ala Ile Val Gly Phe Ser
245 250 255
Asp Asn Val Leu Thr Ala Arg Ala Phe Ala Ser Gly Lys Asp Glu Val
260 265 270
Ile Asp Ser Asn Gln Glu Leu Leu Ala Leu Gly Thr Ala Asn Leu Ala
275 280 285
Asn Gly Phe Phe Gln Gly Phe Pro Val Ser Ser Ser Gly Ser Arg Thr
290 295 300
Val Leu Gly Asp Thr Ala Gly Ala Arg Thr Gln Val His Ser Leu Val
305 310 315 320
Val Val Ala Leu Val Ile Met Val Leu Leu Phe Ala Gly Pro Val Leu
325 330 335
Glu Ser Phe Pro Asp Ala Ala Leu Gly Ala Leu Val Ile Tyr Ala Ala
340 345 350
Thr Gln Leu Ile Asp Ile Ala Glu Ile Lys Arg Ile Ala Arg Phe Arg
355 360 365
Lys Ser Glu Leu Val Ile Thr Ala Ala Thr Ala Ala Ser Val Val Ala
370 375 380
Ser Gly Val Leu Ala Gly Ile Gly Val Ala Val Thr Leu Ser Ile Leu
385 390 395 400
Asp Leu Ile Arg Arg Ile Thr Arg Pro Tyr Ala Asp Val Leu Gly Tyr
405 410 415
Thr Pro Gly Met Ala Gly Met His Ser Leu Glu Asp Tyr Pro Glu Ser
420 425 430
Thr Ala Val Glu Gly Leu Val Val Phe Arg Tyr Asp Ser Pro Leu Phe
435 440 445
Phe Ala Asn Ala Asp Asp Phe Ser Lys Arg Ala Ile Glu Ala Val Asp
450 455 460
Glu Ala Thr Gln Pro Val His Trp Phe Leu Leu Asn Ala Glu Ala Asn
465 470 475 480
Thr Glu Val Asp Leu Thr Ala Val Asp Ala Met Glu Ala Leu Arg Lys
485 490 495
Thr Leu Glu Glu Arg Gly Ile Arg Phe Ala Met Ala Arg Val Lys Gln
500 505 510
Asp Leu Arg Arg Ser Leu Glu Pro Ala Gly Phe Ile Glu Ser Val Gly
515 520 525
Glu Glu Tyr Ile Phe Ala Thr Leu Pro Thr Ala Val Lys Gly Tyr Ser
530 535 540
Val Glu Phe Arg Asp Arg Phe Gly Asn Tyr Pro Glu Gly Val Pro Lys
545 550 555 560
Glu Ile Leu Glu Leu
565
<210> 617
<211> 1734
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1711)
<223> RXA02634
<400> 617
caacgcgaag gcttagttgt ttattaccgg ctcacctacc cggaggtcgc agactttctt 60
aaggtgagcc gctcactatt aaagaggatg gctggcgaag atg cgt gac ctt tta 115
Met Arg Asp Leu Leu
1 5
ccc tct aga gac gac tat cag cta ctc cgc ttc tcc tgg aag atg gac 163
Pro Ser Arg Asp Asp Tyr Gln Leu Leu Arg Phe Ser Trp Lys Met Asp
10 15 20
att gct gct ggc gtc acc gtg ggc att gtt gcc ctc ccc ctc gct ctc 211
Ile Ala Ala Gly Val Thr Val Gly Ile Val Ala Leu Pro Leu Ala Leu
25 30 35
gcc ttt ggt gtg agt tct gga gtc gga gcc gag gca gga tta gtg act 259
Ala Phe Gly Val Ser Ser Gly Val Gly Ala Glu Ala Gly Leu Val Thr
40 45 50
gcg att att gct ggc ctg gtt gca gca atc ttc ggc ggt tcc aat gtg 307
Ala Ile Ile Ala Gly Leu Val Ala Ala Ile Phe Gly Gly Ser Asn Val
55 60 65
cag gtt tca gga cca aca gga gcg atg gtg gtt gtt ctc gct cca atc 355
Gln Val Ser Gly Pro Thr Gly Ala Met Val Val Val Leu Ala Pro Ile
70 75 80 85
gtc gcc caa tat ggt gtc ggt gcg gtt gca tta ctc agc ctg atg gct 403
Val Ala Gln Tyr Gly Val Gly Ala Val Ala Leu Leu Ser Leu Met Ala
90 95 100
gga gtt atc gtc ctt gtc gcc gga gtg ctt cga tta ggc cga acg gtg 451
Gly Val Ile Val Leu Val Ala Gly Val Leu Arg Leu Gly Arg Thr Val
105 110 115
agt ttc att ccg tgg ccg gtc atc gaa gga ttt acg gca ggc atc ggt 499
Ser Phe Ile Pro Trp Pro Val Ile Glu Gly Phe Thr Ala Gly Ile Gly
120 125 130
gtg att att ttc ctg caa cag gtg cca gct gcg ttt ggt tat tcg ggc 547
Val Ile Ile Phe Leu Gln Gln Val Pro Ala Ala Phe Gly Tyr Ser Gly
135 140 145
cat ttg ccc acc aat gcg ctc ctc gct gcg att cac act gtt tca cac 595
His Leu Pro Thr Asn Ala Leu Leu Ala Ala Ile His Thr Val Ser His
150 155 160 165
gcc acg aag gac gca att cta cct ctc tta att att atc gtc acc gct 643
Ala Thr Lys Asp Ala Ile Leu Pro Leu Leu Ile Ile Ile Val Thr Ala
170 175 180
gcg atc atg att gtg ttg gga aag atc gcc cca aag ctc cct gcc agc 691
Ala Ile Met Ile Val Leu Gly Lys Ile Ala Pro Lys Leu Pro Ala Ser
185 190 195
ttc att gcc att ttg gtg gtg tcc att ggc gtg gct ctg ctc aag ctt 739
Phe Ile Ala Ile Leu Val Val Ser Ile Gly Val Ala Leu Leu Lys Leu
200 205 210
ccc gtt gag ttg atc ggt gag ctc ccc aat tcc ctt cct gcc cct cac 787
Pro Val Glu Leu Ile Gly Glu Leu Pro Asn Ser Leu Pro Ala Pro His
215 220 225
ctg cct gat gtg aac ctg gag atg ttc acg agt ttg ctg ggg cca gct 835
Leu Pro Asp Val Asn Leu Glu Met Phe Thr Ser Leu Leu Gly Pro Ala
230 235 240 245
ttt gct gtc gcc gcg ctc gct gct att gag tct ctc ctt tcc gct cgt 883
Phe Ala Val Ala Ala Leu Ala Ala Ile Glu Ser Leu Leu Ser Ala Arg
250 255 260
gtg gca gcc tcc atg gcc gat acg ggt cct tat aat gct gac cgc gaa 931
Val Ala Ala Ser Met Ala Asp Thr Gly Pro Tyr Asn Ala Asp Arg Glu
265 270 275
ttg gtc ggt cag ggg ttg gcg tcg ata agc gct ggc ttt ttt ggc ggc 979
Leu Val Gly Gln Gly Leu Ala Ser Ile Ser Ala Gly Phe Phe Gly Gly
280 285 290
atg ccg gca act ggc gca atc gcg cgt acg gcg gtc aat gtg cgc tcc 1027
Met Pro Ala Thr Gly Ala Ile Ala Arg Thr Ala Val Asn Val Arg Ser
295 300 305
ggc ggg cgt acc cgt ata gcg tcg att att cac gcg ctt gtg ctg ctc 1075
Gly Gly Arg Thr Arg Ile Ala Ser Ile Ile His Ala Leu Val Leu Leu
310 315 320 325
ggc gtt gtg tat gtg gcg gcg aat atc gtt gcg gtc att ccg ctc gcc 1123
Gly Val Val Tyr Val Ala Ala Asn Ile Val Ala Val Ile Pro Leu Ala
330 335 340
gca ctg tcg ggc gtg ctc atg gtc acc gcg agc cgc atg gtg tcc att 1171
Ala Leu Ser Gly Val Leu Met Val Thr Ala Ser Arg Met Val Ser Ile
345 350 355
gaa gtg atc tcg cgc gtc atg cgc tcc act cgc tct gat gcg atc gtt 1219
Glu Val Ile Ser Arg Val Met Arg Ser Thr Arg Ser Asp Ala Ile Val
360 365 370
ttt gtc atc acc gcg atc gtc acc atc agc gtc gac ctc gtc att gcg 1267
Phe Val Ile Thr Ala Ile Val Thr Ile Ser Val Asp Leu Val Ile Ala
375 380 385
gtc ggc atc ggc att gcc gtc gcg acg ttc ttc atg ctg cga cgc atg 1315
Val Gly Ile Gly Ile Ala Val Ala Thr Phe Phe Met Leu Arg Arg Met
390 395 400 405
agc atg aac gcc ggc gtc ttc cgg gaa acc ttg ccc gaa ccg gcc acg 1363
Ser Met Asn Ala Gly Val Phe Arg Glu Thr Leu Pro Glu Pro Ala Thr
410 415 420
ctt aac gac gaa aag atc ggc ctt ttc cgt atc gag ggc gca ttg ttc 1411
Leu Asn Asp Glu Lys Ile Gly Leu Phe Arg Ile Glu Gly Ala Leu Phe
425 430 435
ttt ggc gca gct gaa cgt ctt tcg cag caa atc ctt gat tat gag gac 1459
Phe Gly Ala Ala Glu Arg Leu Ser Gln Gln Ile Leu Asp Tyr Glu Asp
440 445 450
ctc gaa gtg gtg atc ctg cgc ctg tca cac atc caa atg atc gac gcc 1507
Leu Glu Val Val Ile Leu Arg Leu Ser His Ile Gln Met Ile Asp Ala
455 460 465
acc ggc gcc cac cag ctc acc gag ctt gtc aat gcg ctg gaa aga aaa 1555
Thr Gly Ala His Gln Leu Thr Glu Leu Val Asn Ala Leu Glu Arg Lys
470 475 480 485
aat gtc act gta tta att aag ggc gtc cgg aaa gaa cac att cac gtt 1603
Asn Val Thr Val Leu Ile Lys Gly Val Arg Lys Glu His Ile His Val
490 495 500
ctc ggc gtc ctc gga gcg atc aga tca ctg cgg cat gag aac cac ctc 1651
Leu Gly Val Leu Gly Ala Ile Arg Ser Leu Arg His Glu Asn His Leu
505 510 515
ttc gat gac ctt gcc cca gcg gtt gaa cat gcc cga aaa cac gtt aag 1699
Phe Asp Asp Leu Ala Pro Ala Val Glu His Ala Arg Lys His Val Lys
520 525 530
atc gac aac agt taaggcttcc ggggcgatct aaa 1734
Ile Asp Asn Ser
535
<210> 618
<211> 537
<212> PRT
<213> Corynebacterium glutamicum
<400> 618
Met Arg Asp Leu Leu Pro Ser Arg Asp Asp Tyr Gln Leu Leu Arg Phe
1 5 10 15
Ser Trp Lys Met Asp Ile Ala Ala Gly Val Thr Val Gly Ile Val Ala
20 25 30
Leu Pro Leu Ala Leu Ala Phe Gly Val Ser Ser Gly Val Gly Ala Glu
35 40 45
Ala Gly Leu Val Thr Ala Ile Ile Ala Gly Leu Val Ala Ala Ile Phe
50 55 60
Gly Gly Ser Asn Val Gln Val Ser Gly Pro Thr Gly Ala Met Val Val
65 70 75 80
Val Leu Ala Pro Ile Val Ala Gln Tyr Gly Val Gly Ala Val Ala Leu
85 90 95
Leu Ser Leu Met Ala Gly Val Ile Val Leu Val Ala Gly Val Leu Arg
100 105 110
Leu Gly Arg Thr Val Ser Phe Ile Pro Trp Pro Val Ile Glu Gly Phe
115 120 125
Thr Ala Gly Ile Gly Val Ile Ile Phe Leu Gln Gln Val Pro Ala Ala
130 135 140
Phe Gly Tyr Ser Gly His Leu Pro Thr Asn Ala Leu Leu Ala Ala Ile
145 150 155 160
His Thr Val Ser His Ala Thr Lys Asp Ala Ile Leu Pro Leu Leu Ile
165 170 175
Ile Ile Val Thr Ala Ala Ile Met Ile Val Leu Gly Lys Ile Ala Pro
180 185 190
Lys Leu Pro Ala Ser Phe Ile Ala Ile Leu Val Val Ser Ile Gly Val
195 200 205
Ala Leu Leu Lys Leu Pro Val Glu Leu Ile Gly Glu Leu Pro Asn Ser
210 215 220
Leu Pro Ala Pro His Leu Pro Asp Val Asn Leu Glu Met Phe Thr Ser
225 230 235 240
Leu Leu Gly Pro Ala Phe Ala Val Ala Ala Leu Ala Ala Ile Glu Ser
245 250 255
Leu Leu Ser Ala Arg Val Ala Ala Ser Met Ala Asp Thr Gly Pro Tyr
260 265 270
Asn Ala Asp Arg Glu Leu Val Gly Gln Gly Leu Ala Ser Ile Ser Ala
275 280 285
Gly Phe Phe Gly Gly Met Pro Ala Thr Gly Ala Ile Ala Arg Thr Ala
290 295 300
Val Asn Val Arg Ser Gly Gly Arg Thr Arg Ile Ala Ser Ile Ile His
305 310 315 320
Ala Leu Val Leu Leu Gly Val Val Tyr Val Ala Ala Asn Ile Val Ala
325 330 335
Val Ile Pro Leu Ala Ala Leu Ser Gly Val Leu Met Val Thr Ala Ser
340 345 350
Arg Met Val Ser Ile Glu Val Ile Ser Arg Val Met Arg Ser Thr Arg
355 360 365
Ser Asp Ala Ile Val Phe Val Ile Thr Ala Ile Val Thr Ile Ser Val
370 375 380
Asp Leu Val Ile Ala Val Gly Ile Gly Ile Ala Val Ala Thr Phe Phe
385 390 395 400
Met Leu Arg Arg Met Ser Met Asn Ala Gly Val Phe Arg Glu Thr Leu
405 410 415
Pro Glu Pro Ala Thr Leu Asn Asp Glu Lys Ile Gly Leu Phe Arg Ile
420 425 430
Glu Gly Ala Leu Phe Phe Gly Ala Ala Glu Arg Leu Ser Gln Gln Ile
435 440 445
Leu Asp Tyr Glu Asp Leu Glu Val Val Ile Leu Arg Leu Ser His Ile
450 455 460
Gln Met Ile Asp Ala Thr Gly Ala His Gln Leu Thr Glu Leu Val Asn
465 470 475 480
Ala Leu Glu Arg Lys Asn Val Thr Val Leu Ile Lys Gly Val Arg Lys
485 490 495
Glu His Ile His Val Leu Gly Val Leu Gly Ala Ile Arg Ser Leu Arg
500 505 510
His Glu Asn His Leu Phe Asp Asp Leu Ala Pro Ala Val Glu His Ala
515 520 525
Arg Lys His Val Lys Ile Asp Asn Ser
530 535
<210> 619
<211> 1410
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1387)
<223> RXN02233
<400> 619
atccccaccc aattggccca agagctgcag agttacgttg tagaacccac ctctgcctaa 60
ctgtcgattt cccaagagcc cccttgggag tcgataatta gtg ctc gtg act tca 115
Val Leu Val Thr Ser
1 5
aca tgg gga tgg acc gtc cac gga gac ggc aaa aag atc gaa ccc ggc 163
Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys Lys Ile Glu Pro Gly
10 15 20
gca gtt gtc gct cct aaa gag cgc ctg agc tgg ggg cgc aca att gga 211
Ala Val Val Ala Pro Lys Glu Arg Leu Ser Trp Gly Arg Thr Ile Gly
25 30 35
atc ggt atg cag cac gtg atc gcc atg ttc ggc gcc acg ctc ctg gtt 259
Ile Gly Met Gln His Val Ile Ala Met Phe Gly Ala Thr Leu Leu Val
40 45 50
ccc aca ctc acc gga ttt ccg gtc aac acc aca ctt tta ttc tct ggt 307
Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr Leu Leu Phe Ser Gly
55 60 65
ctg gga aca atc ctg ttc ctg ttg atc acc aga aac cga cta ccc tcg 355
Leu Gly Thr Ile Leu Phe Leu Leu Ile Thr Arg Asn Arg Leu Pro Ser
70 75 80 85
tac ctg ggt agt tct ttt gct ttc att gca cct tta acc gca acc caa 403
Tyr Leu Gly Ser Ser Phe Ala Phe Ile Ala Pro Leu Thr Ala Thr Gln
90 95 100
gtc cat ggc att ggc gtg cag atc ggt ggc att ctt gtc gca ggt ctc 451
Val His Gly Ile Gly Val Gln Ile Gly Gly Ile Leu Val Ala Gly Leu
105 110 115
gtg ctc gtc gcc att gga ttt gtg gtg aaa gca gcg ggc aaa cgc gtt 499
Val Leu Val Ala Ile Gly Phe Val Val Lys Ala Ala Gly Lys Arg Val
120 125 130
att gat gct gtc atg cca ccc gct gtc acc ggt gcg atc gtg gca ctc 547
Ile Asp Ala Val Met Pro Pro Ala Val Thr Gly Ala Ile Val Ala Leu
135 140 145
atc ggc ctg aac ctg gca cca acc gcg gca gga aac ttc tcc agc caa 595
Ile Gly Leu Asn Leu Ala Pro Thr Ala Ala Gly Asn Phe Ser Ser Gln
150 155 160 165
cca ctg gtt gcc acg gcg acc ctc ttt gcc att ttg atc gct acc gtt 643
Pro Leu Val Ala Thr Ala Thr Leu Phe Ala Ile Leu Ile Ala Thr Val
170 175 180
gca ggc cgc gga atg att gct cgc ctg ggc att ttg atc ggt gtg gtg 691
Ala Gly Arg Gly Met Ile Ala Arg Leu Gly Ile Leu Ile Gly Val Val
185 190 195
atc ggc tgg gtt ttc gca gct atc acc ggc aac ctc tca gaa ggc gca 739
Ile Gly Trp Val Phe Ala Ala Ile Thr Gly Asn Leu Ser Glu Gly Ala
200 205 210
gca gac acc atc cgt gaa gca gca tgg ttc gga ctg cca cag ttc cac 787
Ala Asp Thr Ile Arg Glu Ala Ala Trp Phe Gly Leu Pro Gln Phe His
215 220 225
aag ccg gaa ttc cag ctc tct gcc att ttg gtg aca ctg cca gtc atc 835
Lys Pro Glu Phe Gln Leu Ser Ala Ile Leu Val Thr Leu Pro Val Ile
230 235 240 245
atc gtg ctc atc gct gaa aac gtc ggc cac gtc aaa gca gtc tca gag 883
Ile Val Leu Ile Ala Glu Asn Val Gly His Val Lys Ala Val Ser Glu
250 255 260
atg aca ggg gag gac ctc gac gac ctc gcc ggc gac gca ctt atc gca 931
Met Thr Gly Glu Asp Leu Asp Asp Leu Ala Gly Asp Ala Leu Ile Ala
265 270 275
gac gga ttc ggc acc acc ctc gca ggt gcc ttc ggt gga tcc ggc acc 979
Asp Gly Phe Gly Thr Thr Leu Ala Gly Ala Phe Gly Gly Ser Gly Thr
280 285 290
acc acc tac gca gaa aac atc ggc gtc atg gcg gcc acc cgc gta tat 1027
Thr Thr Tyr Ala Glu Asn Ile Gly Val Met Ala Ala Thr Arg Val Tyr
295 300 305
tcc acc gct gcg tac tgg gtt gcc gcg tgc act gcc atc gcc ctt gcc 1075
Ser Thr Ala Ala Tyr Trp Val Ala Ala Cys Thr Ala Ile Ala Leu Ala
310 315 320 325
ttc atc ccc aaa ttc ggt gca ctg atc ttc acc atc ccc gcc ggc gtg 1123
Phe Ile Pro Lys Phe Gly Ala Leu Ile Phe Thr Ile Pro Ala Gly Val
330 335 340
ctg ggt ggg gca tgt ttg gtt ctt tac ggc cta atc ggt atg ctc ggc 1171
Leu Gly Gly Ala Cys Leu Val Leu Tyr Gly Leu Ile Gly Met Leu Gly
345 350 355
att cgt atc tgg caa gac aac aag gtc aac ttc aac aat cca gtg aat 1219
Ile Arg Ile Trp Gln Asp Asn Lys Val Asn Phe Asn Asn Pro Val Asn
360 365 370
ctg acc atg gct gcc gtt gct ttg gtt gca ggc att ggt aac ctc acc 1267
Leu Thr Met Ala Ala Val Ala Leu Val Ala Gly Ile Gly Asn Leu Thr
375 380 385
ctc acc gtt ttc gga gtc act ctt gaa ggc atc gca tgg ggc tct gta 1315
Leu Thr Val Phe Gly Val Thr Leu Glu Gly Ile Ala Trp Gly Ser Val
390 395 400 405
ggc atc att gtg ctg tac cca atc atg aag cgc ctg tac ctt tcc att 1363
Gly Ile Ile Val Leu Tyr Pro Ile Met Lys Arg Leu Tyr Leu Ser Ile
410 415 420
ggg gaa ggc aag aac gca aag ttc tagtacgctg ctaaagtatg cag 1410
Gly Glu Gly Lys Asn Ala Lys Phe
425
<210> 620
<211> 429
<212> PRT
<213> Corynebacterium glutamicum
<400> 620
Val Leu Val Thr Ser Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys
1 5 10 15
Lys Ile Glu Pro Gly Ala Val Val Ala Pro Lys Glu Arg Leu Ser Trp
20 25 30
Gly Arg Thr Ile Gly Ile Gly Met Gln His Val Ile Ala Met Phe Gly
35 40 45
Ala Thr Leu Leu Val Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr
50 55 60
Leu Leu Phe Ser Gly Leu Gly Thr Ile Leu Phe Leu Leu Ile Thr Arg
65 70 75 80
Asn Arg Leu Pro Ser Tyr Leu Gly Ser Ser Phe Ala Phe Ile Ala Pro
85 90 95
Leu Thr Ala Thr Gln Val His Gly Ile Gly Val Gln Ile Gly Gly Ile
100 105 110
Leu Val Ala Gly Leu Val Leu Val Ala Ile Gly Phe Val Val Lys Ala
115 120 125
Ala Gly Lys Arg Val Ile Asp Ala Val Met Pro Pro Ala Val Thr Gly
130 135 140
Ala Ile Val Ala Leu Ile Gly Leu Asn Leu Ala Pro Thr Ala Ala Gly
145 150 155 160
Asn Phe Ser Ser Gln Pro Leu Val Ala Thr Ala Thr Leu Phe Ala Ile
165 170 175
Leu Ile Ala Thr Val Ala Gly Arg Gly Met Ile Ala Arg Leu Gly Ile
180 185 190
Leu Ile Gly Val Val Ile Gly Trp Val Phe Ala Ala Ile Thr Gly Asn
195 200 205
Leu Ser Glu Gly Ala Ala Asp Thr Ile Arg Glu Ala Ala Trp Phe Gly
210 215 220
Leu Pro Gln Phe His Lys Pro Glu Phe Gln Leu Ser Ala Ile Leu Val
225 230 235 240
Thr Leu Pro Val Ile Ile Val Leu Ile Ala Glu Asn Val Gly His Val
245 250 255
Lys Ala Val Ser Glu Met Thr Gly Glu Asp Leu Asp Asp Leu Ala Gly
260 265 270
Asp Ala Leu Ile Ala Asp Gly Phe Gly Thr Thr Leu Ala Gly Ala Phe
275 280 285
Gly Gly Ser Gly Thr Thr Thr Tyr Ala Glu Asn Ile Gly Val Met Ala
290 295 300
Ala Thr Arg Val Tyr Ser Thr Ala Ala Tyr Trp Val Ala Ala Cys Thr
305 310 315 320
Ala Ile Ala Leu Ala Phe Ile Pro Lys Phe Gly Ala Leu Ile Phe Thr
325 330 335
Ile Pro Ala Gly Val Leu Gly Gly Ala Cys Leu Val Leu Tyr Gly Leu
340 345 350
Ile Gly Met Leu Gly Ile Arg Ile Trp Gln Asp Asn Lys Val Asn Phe
355 360 365
Asn Asn Pro Val Asn Leu Thr Met Ala Ala Val Ala Leu Val Ala Gly
370 375 380
Ile Gly Asn Leu Thr Leu Thr Val Phe Gly Val Thr Leu Glu Gly Ile
385 390 395 400
Ala Trp Gly Ser Val Gly Ile Ile Val Leu Tyr Pro Ile Met Lys Arg
405 410 415
Leu Tyr Leu Ser Ile Gly Glu Gly Lys Asn Ala Lys Phe
420 425
<210> 621
<211> 1335
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1312)
<223> FRXA02233
<400> 621
atccccaccc aattggccca agagctgcag agttacgttg tagaacccac ctctgcctaa 60
ctgtcgattt cccaagagcc cccttgggag tcgataatta gtg ctc gtg act tca 115
Val Leu Val Thr Ser
1 5
aca tgg gga tgg acc gtc cac gga gac ggc aaa aag atc gaa ccc ggc 163
Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys Lys Ile Glu Pro Gly
10 15 20
gca gtt gtc gct cct aaa gag cgc ctg agc tgg ggg cgc aca att gga 211
Ala Val Val Ala Pro Lys Glu Arg Leu Ser Trp Gly Arg Thr Ile Gly
25 30 35
atc ggt atg cag cac gtg atc gcc atg ttc ggc gcc acg ctc ctg gtt 259
Ile Gly Met Gln His Val Ile Ala Met Phe Gly Ala Thr Leu Leu Val
40 45 50
ccc aca ctc acc gga ttt ccg gtc aac acc aca ctt tta ttc tct ggt 307
Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr Leu Leu Phe Ser Gly
55 60 65
ctg gga aca atc ctg ttc ctg ttg atc acc aga aac cga cta ccc tcg 355
Leu Gly Thr Ile Leu Phe Leu Leu Ile Thr Arg Asn Arg Leu Pro Ser
70 75 80 85
tac ctg ggt agt tct ttt gct ttc att gca cct tta acc gca acc caa 403
Tyr Leu Gly Ser Ser Phe Ala Phe Ile Ala Pro Leu Thr Ala Thr Gln
90 95 100
gtc cat ggc att ggc gtg cag atc ggt ggc att ctt gtc gca ggt ctc 451
Val His Gly Ile Gly Val Gln Ile Gly Gly Ile Leu Val Ala Gly Leu
105 110 115
gtg ctc gtc gcc att gga ttt gtg gtg aaa gca gcg ggc aaa cgc gtt 499
Val Leu Val Ala Ile Gly Phe Val Val Lys Ala Ala Gly Lys Arg Val
120 125 130
att gat gct gtc atg cca ccc gct gtc acc ggt gcg atc gtg gca ctc 547
Ile Asp Ala Val Met Pro Pro Ala Val Thr Gly Ala Ile Val Ala Leu
135 140 145
atc ggc ctg aac ctg gca cca acc gcg gca gga aac ttc tcc agc caa 595
Ile Gly Leu Asn Leu Ala Pro Thr Ala Ala Gly Asn Phe Ser Ser Gln
150 155 160 165
cca ctg gtt gcc acg gcg acc ctc ttt gcc att ttg atc gct acc gtt 643
Pro Leu Val Ala Thr Ala Thr Leu Phe Ala Ile Leu Ile Ala Thr Val
170 175 180
gca ggc cgc gga atg att gct cgc ctg ggc att ttg atc ggt gtg gtg 691
Ala Gly Arg Gly Met Ile Ala Arg Leu Gly Ile Leu Ile Gly Val Val
185 190 195
atc ggc tgg gtt ttc gca gct atc acc ggc aac ctc tca gaa ggc gca 739
Ile Gly Trp Val Phe Ala Ala Ile Thr Gly Asn Leu Ser Glu Gly Ala
200 205 210
gca gac acc atc cgt gaa gca gca tgg ttc gga ctg cca cag ttc cac 787
Ala Asp Thr Ile Arg Glu Ala Ala Trp Phe Gly Leu Pro Gln Phe His
215 220 225
aag ccg gaa ttc cag ctc tct gcc att ttg gtg aca ctg cca gtc atc 835
Lys Pro Glu Phe Gln Leu Ser Ala Ile Leu Val Thr Leu Pro Val Ile
230 235 240 245
atc gtg ctc atc gct gaa aac gtc ggc cac gtc aaa gca gtc tca gag 883
Ile Val Leu Ile Ala Glu Asn Val Gly His Val Lys Ala Val Ser Glu
250 255 260
atg aca ggg gag gac ctc gac gac ctc gcc ggc gac gca ctt atc gca 931
Met Thr Gly Glu Asp Leu Asp Asp Leu Ala Gly Asp Ala Leu Ile Ala
265 270 275
gac gga ttc ggc acc acc ctc gca ggt gcc ttc ggt gga tcc ggc acc 979
Asp Gly Phe Gly Thr Thr Leu Ala Gly Ala Phe Gly Gly Ser Gly Thr
280 285 290
acc acc tac gca gaa aac atc ggc gtc atg gcg gcc acc cgc gta tat 1027
Thr Thr Tyr Ala Glu Asn Ile Gly Val Met Ala Ala Thr Arg Val Tyr
295 300 305
tcc acc gct gcg tac tgg gtt gcc gcg tgc act gcc atc gcc ctt gcc 1075
Ser Thr Ala Ala Tyr Trp Val Ala Ala Cys Thr Ala Ile Ala Leu Ala
310 315 320 325
ttc atc ccc aaa ttc ggt gca ctg atc ttc acc atc ccc gcc ggc gtg 1123
Phe Ile Pro Lys Phe Gly Ala Leu Ile Phe Thr Ile Pro Ala Gly Val
330 335 340
ctg ggt ggg gca tgt ttg gtt ctt tac ggc cta atc ggt atg ctc ggc 1171
Leu Gly Gly Ala Cys Leu Val Leu Tyr Gly Leu Ile Gly Met Leu Gly
345 350 355
att cgt atc tgg caa gac aac aag gtc aac ttc aac aat cca gtg aat 1219
Ile Arg Ile Trp Gln Asp Asn Lys Val Asn Phe Asn Asn Pro Val Asn
360 365 370
ctg acc atg gct gcc gtt gct ttg gtt gca ggc att ggt aac ctc acc 1267
Leu Thr Met Ala Ala Val Ala Leu Val Ala Gly Ile Gly Asn Leu Thr
375 380 385
ctc acc gtt ttc gga gtc act ctt gaa ggc atc gca tgg gct ctg 1312
Leu Thr Val Phe Gly Val Thr Leu Glu Gly Ile Ala Trp Ala Leu
390 395 400
taggcatcat tgtgctgtac cca 1335
<210> 622
<211> 404
<212> PRT
<213> Corynebacterium glutamicum
<400> 622
Val Leu Val Thr Ser Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys
1 5 10 15
Lys Ile Glu Pro Gly Ala Val Val Ala Pro Lys Glu Arg Leu Ser Trp
20 25 30
Gly Arg Thr Ile Gly Ile Gly Met Gln His Val Ile Ala Met Phe Gly
35 40 45
Ala Thr Leu Leu Val Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr
50 55 60
Leu Leu Phe Ser Gly Leu Gly Thr Ile Leu Phe Leu Leu Ile Thr Arg
65 70 75 80
Asn Arg Leu Pro Ser Tyr Leu Gly Ser Ser Phe Ala Phe Ile Ala Pro
85 90 95
Leu Thr Ala Thr Gln Val His Gly Ile Gly Val Gln Ile Gly Gly Ile
100 105 110
Leu Val Ala Gly Leu Val Leu Val Ala Ile Gly Phe Val Val Lys Ala
115 120 125
Ala Gly Lys Arg Val Ile Asp Ala Val Met Pro Pro Ala Val Thr Gly
130 135 140
Ala Ile Val Ala Leu Ile Gly Leu Asn Leu Ala Pro Thr Ala Ala Gly
145 150 155 160
Asn Phe Ser Ser Gln Pro Leu Val Ala Thr Ala Thr Leu Phe Ala Ile
165 170 175
Leu Ile Ala Thr Val Ala Gly Arg Gly Met Ile Ala Arg Leu Gly Ile
180 185 190
Leu Ile Gly Val Val Ile Gly Trp Val Phe Ala Ala Ile Thr Gly Asn
195 200 205
Leu Ser Glu Gly Ala Ala Asp Thr Ile Arg Glu Ala Ala Trp Phe Gly
210 215 220
Leu Pro Gln Phe His Lys Pro Glu Phe Gln Leu Ser Ala Ile Leu Val
225 230 235 240
Thr Leu Pro Val Ile Ile Val Leu Ile Ala Glu Asn Val Gly His Val
245 250 255
Lys Ala Val Ser Glu Met Thr Gly Glu Asp Leu Asp Asp Leu Ala Gly
260 265 270
Asp Ala Leu Ile Ala Asp Gly Phe Gly Thr Thr Leu Ala Gly Ala Phe
275 280 285
Gly Gly Ser Gly Thr Thr Thr Tyr Ala Glu Asn Ile Gly Val Met Ala
290 295 300
Ala Thr Arg Val Tyr Ser Thr Ala Ala Tyr Trp Val Ala Ala Cys Thr
305 310 315 320
Ala Ile Ala Leu Ala Phe Ile Pro Lys Phe Gly Ala Leu Ile Phe Thr
325 330 335
Ile Pro Ala Gly Val Leu Gly Gly Ala Cys Leu Val Leu Tyr Gly Leu
340 345 350
Ile Gly Met Leu Gly Ile Arg Ile Trp Gln Asp Asn Lys Val Asn Phe
355 360 365
Asn Asn Pro Val Asn Leu Thr Met Ala Ala Val Ala Leu Val Ala Gly
370 375 380
Ile Gly Asn Leu Thr Leu Thr Val Phe Gly Val Thr Leu Glu Gly Ile
385 390 395 400
Ala Trp Ala Leu
<210> 623
<211> 2010
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1987)
<223> RXN02372
<400> 623
gacaatactg atggataaat ttcatatcga ggacgaaggg acaaccccga acgccgtgac 60
aacatcaacc acaacccggg tgaaacatcc ggtagaccag gtg cca ccc gca ccc 115
Val Pro Pro Ala Pro
1 5
aaa ctt gca gcc cta ggg ctc caa cac gtt ctt gct ttc tac gca gga 163
Lys Leu Ala Ala Leu Gly Leu Gln His Val Leu Ala Phe Tyr Ala Gly
10 15 20
gcc gtc att gtt ccg ctg ctg att gca cag tcg ctg aac ttg gac act 211
Ala Val Ile Val Pro Leu Leu Ile Ala Gln Ser Leu Asn Leu Asp Thr
25 30 35
gcg acc acc att cac ctg att aac gct gac ttg ttg aca tgt ggc atc 259
Ala Thr Thr Ile His Leu Ile Asn Ala Asp Leu Leu Thr Cys Gly Ile
40 45 50
gcc acg ttg att cag tct gtg ggc att ggt cgc cac att ggt gtg cgc 307
Ala Thr Leu Ile Gln Ser Val Gly Ile Gly Arg His Ile Gly Val Arg
55 60 65
cta ccg atc gtt caa ggt gtc acc act act gct gtt gct ccc atc atc 355
Leu Pro Ile Val Gln Gly Val Thr Thr Thr Ala Val Ala Pro Ile Ile
70 75 80 85
gcc att ggt ttg ggc gtt act gat ggt caa ggt ggc gtt gcg tcg ctg 403
Ala Ile Gly Leu Gly Val Thr Asp Gly Gln Gly Gly Val Ala Ser Leu
90 95 100
cct gcc att tac ggt gca gtc att gtc tcc ggc att ttc acg ttc ttt 451
Pro Ala Ile Tyr Gly Ala Val Ile Val Ser Gly Ile Phe Thr Phe Phe
105 110 115
gca gcg ccg gtg ttt gcg cgt ttc ctc aag ttc ttc cca cca gtt gtc 499
Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe Phe Pro Pro Val Val
120 125 130
acc ggt act gtg ctg ttg gtt atg ggt gct tcc ctg ctg tcg gta tct 547
Thr Gly Thr Val Leu Leu Val Met Gly Ala Ser Leu Leu Ser Val Ser
135 140 145
gca aat gac ttt gtg aac tac gcc gat ggg gtg cct gct gcc cgc gat 595
Ala Asn Asp Phe Val Asn Tyr Ala Asp Gly Val Pro Ala Ala Arg Asp
150 155 160 165
ctt gct tac ggt ttt ggc acc ttg gcg gtg atc att ttg gcg cag cgc 643
Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val Ile Ile Leu Ala Gln Arg
170 175 180
ttc ttc cgt gga ttc atg ggc acc ttg gct gtg ttg atc ggc ctg gtt 691
Phe Phe Arg Gly Phe Met Gly Thr Leu Ala Val Leu Ile Gly Leu Val
185 190 195
ggt ggc acc gca gtt gct ctg atc ttg ggc gat gcc aac ttg gat gag 739
Gly Gly Thr Ala Val Ala Leu Ile Leu Gly Asp Ala Asn Leu Asp Glu
200 205 210
gtg gga aat gct gaa gcg ttc gac atc acc act ccg ttt tat ttt ggt 787
Val Gly Asn Ala Glu Ala Phe Asp Ile Thr Thr Pro Phe Tyr Phe Gly
215 220 225
gtt cca gaa ttt aac gct gtt gcc att ttc tcc atg att atc gtc atg 835
Val Pro Glu Phe Asn Ala Val Ala Ile Phe Ser Met Ile Ile Val Met
230 235 240 245
atc atc acc atg gtg gag acc acc ggt gat gtg ttt gca acg ggg gaa 883
Ile Ile Thr Met Val Glu Thr Thr Gly Asp Val Phe Ala Thr Gly Glu
250 255 260
atc gtc ggc aag cga act cgc cgc agt gat gtc acc cgc gca ctg cgc 931
Ile Val Gly Lys Arg Thr Arg Arg Ser Asp Val Thr Arg Ala Leu Arg
265 270 275
gct gac ggc ctg tcc acc ctg atg ggt ggc gtc atg aac tcc ttc ccg 979
Ala Asp Gly Leu Ser Thr Leu Met Gly Gly Val Met Asn Ser Phe Pro
280 285 290
tac acg tgc ttc gcg caa aac gtt ggc ctg gtg cgc atc acg ggc gtg 1027
Tyr Thr Cys Phe Ala Gln Asn Val Gly Leu Val Arg Ile Thr Gly Val
295 300 305
aaa tct cgc tgg gtt gcg gca gct gct gcc ggc ttc atg atc atc ctc 1075
Lys Ser Arg Trp Val Ala Ala Ala Ala Ala Gly Phe Met Ile Ile Leu
310 315 320 325
ggt gtg ctg ccc aag gct ggc gcg atc gtc gct tcc atc cct tcc cca 1123
Gly Val Leu Pro Lys Ala Gly Ala Ile Val Ala Ser Ile Pro Ser Pro
330 335 340
gtc ctc ggt ggc gca tcc ttg gca ctg ttc gcc aac gtt gca tgg gtg 1171
Val Leu Gly Gly Ala Ser Leu Ala Leu Phe Ala Asn Val Ala Trp Val
345 350 355
ggc atc cag acc atc gcc aag tct gac ctc gct gat agc cgc aac tcc 1219
Gly Ile Gln Thr Ile Ala Lys Ser Asp Leu Ala Asp Ser Arg Asn Ser
360 365 370
gtc atc gtg acc tcc gca ctt ggc cta gcc atg ctg gtg tcc ttc cgc 1267
Val Ile Val Thr Ser Ala Leu Gly Leu Ala Met Leu Val Ser Phe Arg
375 380 385
ccc gat gtt gct cag gcg ttc cct gag tgg gcg cgt atc ttc gtc tcc 1315
Pro Asp Val Ala Gln Ala Phe Pro Glu Trp Ala Arg Ile Phe Val Ser
390 395 400 405
tcc ggc atg tcc gtc ggc gcg atc acc gcg atc ctg ctt aac ctg ctg 1363
Ser Gly Met Ser Val Gly Ala Ile Thr Ala Ile Leu Leu Asn Leu Leu
410 415 420
ttc ttc cac gtc gga cgc caa tcc ggt gga caa gtc gct acc tca aaa 1411
Phe Phe His Val Gly Arg Gln Ser Gly Gly Gln Val Ala Thr Ser Lys
425 430 435
tcc ggt gag cgc atc aat ttg gat gcg gtc aac aag atg gat cgc acc 1459
Ser Gly Glu Arg Ile Asn Leu Asp Ala Val Asn Lys Met Asp Arg Thr
440 445 450
gac ttc gta gaa acc ttc gca ccg ctg ttc aac agc aag acc tgg cct 1507
Asp Phe Val Glu Thr Phe Ala Pro Leu Phe Asn Ser Lys Thr Trp Pro
455 460 465
ttg gaa acc gca tgg gaa tcc cag cca ttc gcc aac gtc acg gaa ctg 1555
Leu Glu Thr Ala Trp Glu Ser Gln Pro Phe Ala Asn Val Thr Glu Leu
470 475 480 485
cgc gaa gcc atc caa gtc gct gtg ctc acc gca ccg ttg tcc gac cgc 1603
Arg Glu Ala Ile Gln Val Ala Val Leu Thr Ala Pro Leu Ser Asp Arg
490 495 500
gaa gag ctc atc cac gac tac ccc gac atg gca cag ctc att ttg gcc 1651
Glu Glu Leu Ile His Asp Tyr Pro Asp Met Ala Gln Leu Ile Leu Ala
505 510 515
acc gaa gag gaa gcc gcc acc atc tct caa gac cgt ggt tcg atc ggt 1699
Thr Glu Glu Glu Ala Ala Thr Ile Ser Gln Asp Arg Gly Ser Ile Gly
520 525 530
ctt gat gat ctc gat gac gtg gat caa gaa aag ctc atc acc gtc acc 1747
Leu Asp Asp Leu Asp Asp Val Asp Gln Glu Lys Leu Ile Thr Val Thr
535 540 545
gag cag tac cgc gaa cgg ttc aac atg ccg tat gtt gcg tac ttc gac 1795
Glu Gln Tyr Arg Glu Arg Phe Asn Met Pro Tyr Val Ala Tyr Phe Asp
550 555 560 565
acc atg gat tct gtg gat acc gtc gta gcc gcc ggc ttg cgc cgc ctc 1843
Thr Met Asp Ser Val Asp Thr Val Val Ala Ala Gly Leu Arg Arg Leu
570 575 580
gac aac tcc gac gag cag gag cac cgc caa gcg cta tcg gaa atc att 1891
Asp Asn Ser Asp Glu Gln Glu His Arg Gln Ala Leu Ser Glu Ile Ile
585 590 595
gag att gcc aat gac cgc ttc gat ata ttg ctt gcc gac gct aac cca 1939
Glu Ile Ala Asn Asp Arg Phe Asp Ile Leu Leu Ala Asp Ala Asn Pro
600 605 610
gcc cgt tca gct ttc gat cgc aag ttt acc gag act gac ttc ctc ggc 1987
Ala Arg Ser Ala Phe Asp Arg Lys Phe Thr Glu Thr Asp Phe Leu Gly
615 620 625
taaaacacca aaaacaaatt aag 2010
<210> 624
<211> 629
<212> PRT
<213> Corynebacterium glutamicum
<400> 624
Val Pro Pro Ala Pro Lys Leu Ala Ala Leu Gly Leu Gln His Val Leu
1 5 10 15
Ala Phe Tyr Ala Gly Ala Val Ile Val Pro Leu Leu Ile Ala Gln Ser
20 25 30
Leu Asn Leu Asp Thr Ala Thr Thr Ile His Leu Ile Asn Ala Asp Leu
35 40 45
Leu Thr Cys Gly Ile Ala Thr Leu Ile Gln Ser Val Gly Ile Gly Arg
50 55 60
His Ile Gly Val Arg Leu Pro Ile Val Gln Gly Val Thr Thr Thr Ala
65 70 75 80
Val Ala Pro Ile Ile Ala Ile Gly Leu Gly Val Thr Asp Gly Gln Gly
85 90 95
Gly Val Ala Ser Leu Pro Ala Ile Tyr Gly Ala Val Ile Val Ser Gly
100 105 110
Ile Phe Thr Phe Phe Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe
115 120 125
Phe Pro Pro Val Val Thr Gly Thr Val Leu Leu Val Met Gly Ala Ser
130 135 140
Leu Leu Ser Val Ser Ala Asn Asp Phe Val Asn Tyr Ala Asp Gly Val
145 150 155 160
Pro Ala Ala Arg Asp Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val Ile
165 170 175
Ile Leu Ala Gln Arg Phe Phe Arg Gly Phe Met Gly Thr Leu Ala Val
180 185 190
Leu Ile Gly Leu Val Gly Gly Thr Ala Val Ala Leu Ile Leu Gly Asp
195 200 205
Ala Asn Leu Asp Glu Val Gly Asn Ala Glu Ala Phe Asp Ile Thr Thr
210 215 220
Pro Phe Tyr Phe Gly Val Pro Glu Phe Asn Ala Val Ala Ile Phe Ser
225 230 235 240
Met Ile Ile Val Met Ile Ile Thr Met Val Glu Thr Thr Gly Asp Val
245 250 255
Phe Ala Thr Gly Glu Ile Val Gly Lys Arg Thr Arg Arg Ser Asp Val
260 265 270
Thr Arg Ala Leu Arg Ala Asp Gly Leu Ser Thr Leu Met Gly Gly Val
275 280 285
Met Asn Ser Phe Pro Tyr Thr Cys Phe Ala Gln Asn Val Gly Leu Val
290 295 300
Arg Ile Thr Gly Val Lys Ser Arg Trp Val Ala Ala Ala Ala Ala Gly
305 310 315 320
Phe Met Ile Ile Leu Gly Val Leu Pro Lys Ala Gly Ala Ile Val Ala
325 330 335
Ser Ile Pro Ser Pro Val Leu Gly Gly Ala Ser Leu Ala Leu Phe Ala
340 345 350
Asn Val Ala Trp Val Gly Ile Gln Thr Ile Ala Lys Ser Asp Leu Ala
355 360 365
Asp Ser Arg Asn Ser Val Ile Val Thr Ser Ala Leu Gly Leu Ala Met
370 375 380
Leu Val Ser Phe Arg Pro Asp Val Ala Gln Ala Phe Pro Glu Trp Ala
385 390 395 400
Arg Ile Phe Val Ser Ser Gly Met Ser Val Gly Ala Ile Thr Ala Ile
405 410 415
Leu Leu Asn Leu Leu Phe Phe His Val Gly Arg Gln Ser Gly Gly Gln
420 425 430
Val Ala Thr Ser Lys Ser Gly Glu Arg Ile Asn Leu Asp Ala Val Asn
435 440 445
Lys Met Asp Arg Thr Asp Phe Val Glu Thr Phe Ala Pro Leu Phe Asn
450 455 460
Ser Lys Thr Trp Pro Leu Glu Thr Ala Trp Glu Ser Gln Pro Phe Ala
465 470 475 480
Asn Val Thr Glu Leu Arg Glu Ala Ile Gln Val Ala Val Leu Thr Ala
485 490 495
Pro Leu Ser Asp Arg Glu Glu Leu Ile His Asp Tyr Pro Asp Met Ala
500 505 510
Gln Leu Ile Leu Ala Thr Glu Glu Glu Ala Ala Thr Ile Ser Gln Asp
515 520 525
Arg Gly Ser Ile Gly Leu Asp Asp Leu Asp Asp Val Asp Gln Glu Lys
530 535 540
Leu Ile Thr Val Thr Glu Gln Tyr Arg Glu Arg Phe Asn Met Pro Tyr
545 550 555 560
Val Ala Tyr Phe Asp Thr Met Asp Ser Val Asp Thr Val Val Ala Ala
565 570 575
Gly Leu Arg Arg Leu Asp Asn Ser Asp Glu Gln Glu His Arg Gln Ala
580 585 590
Leu Ser Glu Ile Ile Glu Ile Ala Asn Asp Arg Phe Asp Ile Leu Leu
595 600 605
Ala Asp Ala Asn Pro Ala Arg Ser Ala Phe Asp Arg Lys Phe Thr Glu
610 615 620
Thr Asp Phe Leu Gly
625
<210> 625
<211> 578
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(555)
<223> FRXA02372
<400> 625
gat gcg gtc aac aag atg gat cgc acc gac ttc gta gaa acc ttc gca 48
Asp Ala Val Asn Lys Met Asp Arg Thr Asp Phe Val Glu Thr Phe Ala
1 5 10 15
ccg ctg ttc aac agc aag acc tgg cct ttg gaa acc gca tgg gaa tcc 96
Pro Leu Phe Asn Ser Lys Thr Trp Pro Leu Glu Thr Ala Trp Glu Ser
20 25 30
cag cca ttc gcc aac gtc acg gaa ctg cgc gaa gcc atc caa gtc gct 144
Gln Pro Phe Ala Asn Val Thr Glu Leu Arg Glu Ala Ile Gln Val Ala
35 40 45
gtg ctc acc gca ccg ttg tcc gac cgc gaa gag ctc atc cac gac tac 192
Val Leu Thr Ala Pro Leu Ser Asp Arg Glu Glu Leu Ile His Asp Tyr
50 55 60
ccc gac atg gca cag ctc att ttg gcc acc gaa gag gaa gcc gcc acc 240
Pro Asp Met Ala Gln Leu Ile Leu Ala Thr Glu Glu Glu Ala Ala Thr
65 70 75 80
atc tct caa gac cgt ggt tcg atc ggt ctt gat gat ctc gat gac gtg 288
Ile Ser Gln Asp Arg Gly Ser Ile Gly Leu Asp Asp Leu Asp Asp Val
85 90 95
gat caa gaa aag ctc atc acc gtc acc gag cag tac cgc gaa cgg ttc 336
Asp Gln Glu Lys Leu Ile Thr Val Thr Glu Gln Tyr Arg Glu Arg Phe
100 105 110
aac atg ccg tat gtt gcg tac ttc gac acc atg gat tct gtg gat acc 384
Asn Met Pro Tyr Val Ala Tyr Phe Asp Thr Met Asp Ser Val Asp Thr
115 120 125
gtc gta gcc gcc ggc ttg cgc cgc ctc gac aac tcc gac gag cag gag 432
Val Val Ala Ala Gly Leu Arg Arg Leu Asp Asn Ser Asp Glu Gln Glu
130 135 140
cac cgc caa gcg cta tcg gaa atc att gag att gcc aat gac cgc ttc 480
His Arg Gln Ala Leu Ser Glu Ile Ile Glu Ile Ala Asn Asp Arg Phe
145 150 155 160
gat ata ttg ctt gcc gac gct aac cca gcc cgt tca gct ttc gat cgc 528
Asp Ile Leu Leu Ala Asp Ala Asn Pro Ala Arg Ser Ala Phe Asp Arg
165 170 175
aag ttt acc gag act gac ttc ctc ggc taaaacacca aaaacaaatt 575
Lys Phe Thr Glu Thr Asp Phe Leu Gly
180 185
aag 578
<210> 626
<211> 185
<212> PRT
<213> Corynebacterium glutamicum
<400> 626
Asp Ala Val Asn Lys Met Asp Arg Thr Asp Phe Val Glu Thr Phe Ala
1 5 10 15
Pro Leu Phe Asn Ser Lys Thr Trp Pro Leu Glu Thr Ala Trp Glu Ser
20 25 30
Gln Pro Phe Ala Asn Val Thr Glu Leu Arg Glu Ala Ile Gln Val Ala
35 40 45
Val Leu Thr Ala Pro Leu Ser Asp Arg Glu Glu Leu Ile His Asp Tyr
50 55 60
Pro Asp Met Ala Gln Leu Ile Leu Ala Thr Glu Glu Glu Ala Ala Thr
65 70 75 80
Ile Ser Gln Asp Arg Gly Ser Ile Gly Leu Asp Asp Leu Asp Asp Val
85 90 95
Asp Gln Glu Lys Leu Ile Thr Val Thr Glu Gln Tyr Arg Glu Arg Phe
100 105 110
Asn Met Pro Tyr Val Ala Tyr Phe Asp Thr Met Asp Ser Val Asp Thr
115 120 125
Val Val Ala Ala Gly Leu Arg Arg Leu Asp Asn Ser Asp Glu Gln Glu
130 135 140
His Arg Gln Ala Leu Ser Glu Ile Ile Glu Ile Ala Asn Asp Arg Phe
145 150 155 160
Asp Ile Leu Leu Ala Asp Ala Asn Pro Ala Arg Ser Ala Phe Asp Arg
165 170 175
Lys Phe Thr Glu Thr Asp Phe Leu Gly
180 185
<210> 627
<211> 1314
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1291)
<223> FRXA02377
<400> 627
gacaatactg atggataaat ttcatatcga ggacgaaggg acaaccccga acgccgtgac 60
aacatcaacc acaacccggg tgaaacatcc ggtagaccag gtg cca ccc gca ccc 115
Val Pro Pro Ala Pro
1 5
aaa ctt gca gcc cta ggg ctc caa cac gtt ctt gct ttc tac gca gga 163
Lys Leu Ala Ala Leu Gly Leu Gln His Val Leu Ala Phe Tyr Ala Gly
10 15 20
gcc gtc att gtt ccg ctg ctg att gca cag tcg ctg aac ttg gac act 211
Ala Val Ile Val Pro Leu Leu Ile Ala Gln Ser Leu Asn Leu Asp Thr
25 30 35
gcg acc acc att cac ctg att aac gct gac ttg ttg aca tgt ggc atc 259
Ala Thr Thr Ile His Leu Ile Asn Ala Asp Leu Leu Thr Cys Gly Ile
40 45 50
gcc acg ttg att cag tct gtg ggc att ggt cgc cac att ggt gtg cgc 307
Ala Thr Leu Ile Gln Ser Val Gly Ile Gly Arg His Ile Gly Val Arg
55 60 65
cta ccg atc gtt caa ggt gtc acc act act gct gtt gct ccc atc atc 355
Leu Pro Ile Val Gln Gly Val Thr Thr Thr Ala Val Ala Pro Ile Ile
70 75 80 85
gcc att ggt ttg ggc gtt act gat ggt caa ggt ggc gtt gcg tcg ctg 403
Ala Ile Gly Leu Gly Val Thr Asp Gly Gln Gly Gly Val Ala Ser Leu
90 95 100
cct gcc att tac ggt gca gtc att gtc tcc ggc att ttc acg ttc ttt 451
Pro Ala Ile Tyr Gly Ala Val Ile Val Ser Gly Ile Phe Thr Phe Phe
105 110 115
gca gcg ccg gtg ttt gcg cgt ttc ctc aag ttc ttc cca cca gtt gtc 499
Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe Phe Pro Pro Val Val
120 125 130
acc ggt act gtg ctg ttg gtt atg ggt gct tcc ctg ctg tcg gta tct 547
Thr Gly Thr Val Leu Leu Val Met Gly Ala Ser Leu Leu Ser Val Ser
135 140 145
gca aat gac ttt gtg aac tac gcc gat ggg gtg cct gct gcc cgc gat 595
Ala Asn Asp Phe Val Asn Tyr Ala Asp Gly Val Pro Ala Ala Arg Asp
150 155 160 165
ctt gct tac ggt ttt ggc acc ttg gcg gtg atc att ttg gcg cag cgc 643
Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val Ile Ile Leu Ala Gln Arg
170 175 180
ttc ttc cgt gga ttc atg ggc acc ttg gct gtg ttg atc ggc ctg gtt 691
Phe Phe Arg Gly Phe Met Gly Thr Leu Ala Val Leu Ile Gly Leu Val
185 190 195
ggt ggc acc gca gtt gct ctg atc ttg ggc gat gcc aac ttg gat gag 739
Gly Gly Thr Ala Val Ala Leu Ile Leu Gly Asp Ala Asn Leu Asp Glu
200 205 210
gtg gga aat gct gaa gcg ttc gac atc acc act ccg ttt tat ttt ggt 787
Val Gly Asn Ala Glu Ala Phe Asp Ile Thr Thr Pro Phe Tyr Phe Gly
215 220 225
gtt cca gaa ttt aac gct gtt gcc att ttc tcc atg att atc gtc atg 835
Val Pro Glu Phe Asn Ala Val Ala Ile Phe Ser Met Ile Ile Val Met
230 235 240 245
atc atc acc atg gtg gag acc acc ggt gat gtg ttt gca acg ggg gaa 883
Ile Ile Thr Met Val Glu Thr Thr Gly Asp Val Phe Ala Thr Gly Glu
250 255 260
atc gtc ggc aag cga act cgc cgc agt gat gtc acc cgc gca ctg cgc 931
Ile Val Gly Lys Arg Thr Arg Arg Ser Asp Val Thr Arg Ala Leu Arg
265 270 275
gct gac ggc ctg tcc acc ctg atg ggt ggc gtc atg aac tcc ttc ccg 979
Ala Asp Gly Leu Ser Thr Leu Met Gly Gly Val Met Asn Ser Phe Pro
280 285 290
tac acg tgc ttc gcg caa aac gtt ggc ctg gtg cgc atc acg ggc gtg 1027
Tyr Thr Cys Phe Ala Gln Asn Val Gly Leu Val Arg Ile Thr Gly Val
295 300 305
aaa tct cgc tgg gtt gcg gca gct gct gcc ggc ttc atg atc atc ctc 1075
Lys Ser Arg Trp Val Ala Ala Ala Ala Ala Gly Phe Met Ile Ile Leu
310 315 320 325
ggt gtg ctg ccc aag gct ggc gcg atc gtc gct tcc atc cct tcc cca 1123
Gly Val Leu Pro Lys Ala Gly Ala Ile Val Ala Ser Ile Pro Ser Pro
330 335 340
gtc ctc ggt ggc gca tcc ttg gca ctg ttc gcc aac gtt gca tgg gtg 1171
Val Leu Gly Gly Ala Ser Leu Ala Leu Phe Ala Asn Val Ala Trp Val
345 350 355
ggc atc cag acc atc gcc aag tct gac ctc gct gat agc cgc aac tcc 1219
Gly Ile Gln Thr Ile Ala Lys Ser Asp Leu Ala Asp Ser Arg Asn Ser
360 365 370
gtc atc gtg acc tcc gca ctt ggc cta gcc atg ctg gtg tcc ttc cgc 1267
Val Ile Val Thr Ser Ala Leu Gly Leu Ala Met Leu Val Ser Phe Arg
375 380 385
ccc gat gtt gct caa ggc gtt ccc tgagtgggcg cgtatcttcg tct 1314
Pro Asp Val Ala Gln Gly Val Pro
390 395
<210> 628
<211> 397
<212> PRT
<213> Corynebacterium glutamicum
<400> 628
Val Pro Pro Ala Pro Lys Leu Ala Ala Leu Gly Leu Gln His Val Leu
1 5 10 15
Ala Phe Tyr Ala Gly Ala Val Ile Val Pro Leu Leu Ile Ala Gln Ser
20 25 30
Leu Asn Leu Asp Thr Ala Thr Thr Ile His Leu Ile Asn Ala Asp Leu
35 40 45
Leu Thr Cys Gly Ile Ala Thr Leu Ile Gln Ser Val Gly Ile Gly Arg
50 55 60
His Ile Gly Val Arg Leu Pro Ile Val Gln Gly Val Thr Thr Thr Ala
65 70 75 80
Val Ala Pro Ile Ile Ala Ile Gly Leu Gly Val Thr Asp Gly Gln Gly
85 90 95
Gly Val Ala Ser Leu Pro Ala Ile Tyr Gly Ala Val Ile Val Ser Gly
100 105 110
Ile Phe Thr Phe Phe Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe
115 120 125
Phe Pro Pro Val Val Thr Gly Thr Val Leu Leu Val Met Gly Ala Ser
130 135 140
Leu Leu Ser Val Ser Ala Asn Asp Phe Val Asn Tyr Ala Asp Gly Val
145 150 155 160
Pro Ala Ala Arg Asp Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val Ile
165 170 175
Ile Leu Ala Gln Arg Phe Phe Arg Gly Phe Met Gly Thr Leu Ala Val
180 185 190
Leu Ile Gly Leu Val Gly Gly Thr Ala Val Ala Leu Ile Leu Gly Asp
195 200 205
Ala Asn Leu Asp Glu Val Gly Asn Ala Glu Ala Phe Asp Ile Thr Thr
210 215 220
Pro Phe Tyr Phe Gly Val Pro Glu Phe Asn Ala Val Ala Ile Phe Ser
225 230 235 240
Met Ile Ile Val Met Ile Ile Thr Met Val Glu Thr Thr Gly Asp Val
245 250 255
Phe Ala Thr Gly Glu Ile Val Gly Lys Arg Thr Arg Arg Ser Asp Val
260 265 270
Thr Arg Ala Leu Arg Ala Asp Gly Leu Ser Thr Leu Met Gly Gly Val
275 280 285
Met Asn Ser Phe Pro Tyr Thr Cys Phe Ala Gln Asn Val Gly Leu Val
290 295 300
Arg Ile Thr Gly Val Lys Ser Arg Trp Val Ala Ala Ala Ala Ala Gly
305 310 315 320
Phe Met Ile Ile Leu Gly Val Leu Pro Lys Ala Gly Ala Ile Val Ala
325 330 335
Ser Ile Pro Ser Pro Val Leu Gly Gly Ala Ser Leu Ala Leu Phe Ala
340 345 350
Asn Val Ala Trp Val Gly Ile Gln Thr Ile Ala Lys Ser Asp Leu Ala
355 360 365
Asp Ser Arg Asn Ser Val Ile Val Thr Ser Ala Leu Gly Leu Ala Met
370 375 380
Leu Val Ser Phe Arg Pro Asp Val Ala Gln Gly Val Pro
385 390 395
<210> 629
<211> 1512
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1489)
<223> RXA02676
<400> 629
aaccattggg tattaagaaa tttgtggctt agatctcaat ttctgtatag tttgatcata 60
ctaattcatc cacttccaaa ttttcacgaa ggatcacccc atg gac acc tgg gaa 115
Met Asp Thr Trp Glu
1 5
caa acc ctt gga aca ggg cca ctg cta ggc att gca gcc ggc gcc att 163
Gln Thr Leu Gly Thr Gly Pro Leu Leu Gly Ile Ala Ala Gly Ala Ile
10 15 20
gcc ctc atc ttg gtt ctc gtc atc gtt ttt aaa ctc cat gct ttt ctc 211
Ala Leu Ile Leu Val Leu Val Ile Val Phe Lys Leu His Ala Phe Leu
25 30 35
acc cta ata ctg gtt tca att gtt acc gca ctt gct gcc ggc att ccc 259
Thr Leu Ile Leu Val Ser Ile Val Thr Ala Leu Ala Ala Gly Ile Pro
40 45 50
gtc acc gca gta gtg gac act ctc ctt gac ggt ttt ggt aaa aca ctc 307
Val Thr Ala Val Val Asp Thr Leu Leu Asp Gly Phe Gly Lys Thr Leu
55 60 65
gcc tcg gtc gcc cta ttg gta ggc ctg ggt gcc atg ctt ggt cga ttg 355
Ala Ser Val Ala Leu Leu Val Gly Leu Gly Ala Met Leu Gly Arg Leu
70 75 80 85
gtt gaa aca tcc ggt ggc gca aaa tct cta gcc gac act atg gtg cga 403
Val Glu Thr Ser Gly Gly Ala Lys Ser Leu Ala Asp Thr Met Val Arg
90 95 100
atc ttc ggt gaa aaa cga gca gct ttc gca ctc ggt gtc gca tcg ctg 451
Ile Phe Gly Glu Lys Arg Ala Ala Phe Ala Leu Gly Val Ala Ser Leu
105 110 115
atc atg gga ttc cct atc ttc ttc gat gct ggc ctc gtg gtc atg ctc 499
Ile Met Gly Phe Pro Ile Phe Phe Asp Ala Gly Leu Val Val Met Leu
120 125 130
cca gtg atc ttc gca gta gct cga cgc ctc aac ggc tcc gtc ctt act 547
Pro Val Ile Phe Ala Val Ala Arg Arg Leu Asn Gly Ser Val Leu Thr
135 140 145
ttt ggt atc cct gca gct ggc gcc ttc tct gtc atg cac gtg ttc gtc 595
Phe Gly Ile Pro Ala Ala Gly Ala Phe Ser Val Met His Val Phe Val
150 155 160 165
cca cct cac cca ggc cca att gca gcc tct gaa ttc ttc ggc gca caa 643
Pro Pro His Pro Gly Pro Ile Ala Ala Ser Glu Phe Phe Gly Ala Gln
170 175 180
gtt gga tac gta cta atc gct ggc atc atc gtt gca cta ccc acc tgg 691
Val Gly Tyr Val Leu Ile Ala Gly Ile Ile Val Ala Leu Pro Thr Trp
185 190 195
tat tta acc ggt tac ctg cta ggt aag ttc tta ggc cga aag ttc ccc 739
Tyr Leu Thr Gly Tyr Leu Leu Gly Lys Phe Leu Gly Arg Lys Phe Pro
200 205 210
ctt ccc gta ccc gat cta ctc agt ggt gga gca cag gaa gat gat cag 787
Leu Pro Val Pro Asp Leu Leu Ser Gly Gly Ala Gln Glu Asp Asp Gln
215 220 225
cct cag aac cca gct aac gca gtg tcg atc att gtc att ttg ctc att 835
Pro Gln Asn Pro Ala Asn Ala Val Ser Ile Ile Val Ile Leu Leu Ile
230 235 240 245
cct atg ctc ctt att ttt ggc aat acc gga aca tca atg gca gtt tcc 883
Pro Met Leu Leu Ile Phe Gly Asn Thr Gly Thr Ser Met Ala Val Ser
250 255 260
gcc ggc ctc cta gat gca gaa tcc acc atg gtg aaa att cta gga ttc 931
Ala Gly Leu Leu Asp Ala Glu Ser Thr Met Val Lys Ile Leu Gly Phe
265 270 275
ctc ggc gaa aca cca gtg gca ctg ctc att acc ttg atc att gcc ctg 979
Leu Gly Glu Thr Pro Val Ala Leu Leu Ile Thr Leu Ile Ile Ala Leu
280 285 290
ttc ttc cta ggc aac cga cgt ggc att aat ggt tct gct cta gag aaa 1027
Phe Phe Leu Gly Asn Arg Arg Gly Ile Asn Gly Ser Ala Leu Glu Lys
295 300 305
acc atc gaa ggc gca ctc ggc cca atc tgt tca gtc gta tta atc act 1075
Thr Ile Glu Gly Ala Leu Gly Pro Ile Cys Ser Val Val Leu Ile Thr
310 315 320 325
ggc gcc ggt ggc atg ttc ggt gga gtg cta cgc acg tct gga att gga 1123
Gly Ala Gly Gly Met Phe Gly Gly Val Leu Arg Thr Ser Gly Ile Gly
330 335 340
gga gcg ctt gca gac tcc atg gca gat cta gga ctt cca gtt atc gca 1171
Gly Ala Leu Ala Asp Ser Met Ala Asp Leu Gly Leu Pro Val Ile Ala
345 350 355
ggt tgt ttc atc gtg gca gcc gtc ctt cgt gtc gcg cag ggt tct gcc 1219
Gly Cys Phe Ile Val Ala Ala Val Leu Arg Val Ala Gln Gly Ser Ala
360 365 370
acc gtt gcg cta acc acc gcc gca gca ctc atg gca cct gct gtt gcc 1267
Thr Val Ala Leu Thr Thr Ala Ala Ala Leu Met Ala Pro Ala Val Ala
375 380 385
gct gct gac ttt aac gaa ttc cag ctt gct gcc atc gtt att tcc act 1315
Ala Ala Asp Phe Asn Glu Phe Gln Leu Ala Ala Ile Val Ile Ser Thr
390 395 400 405
gcc gct ggt tct gtt att gcc agc cac gtc aac gac tcc gga ttc tgg 1363
Ala Ala Gly Ser Val Ile Ala Ser His Val Asn Asp Ser Gly Phe Trp
410 415 420
ctc gtt ggt cga ctc atg aac gcc gac gta ccc acc acg cta aaa act 1411
Leu Val Gly Arg Leu Met Asn Ala Asp Val Pro Thr Thr Leu Lys Thr
425 430 435
tgg acc gta aac caa acc tgc att gcg att gtg gga ttt gtg atg gcc 1459
Trp Thr Val Asn Gln Thr Cys Ile Ala Ile Val Gly Phe Val Met Ala
440 445 450
tat gca atg ttc gga ttg gca tcg ctt gca tagtccgctg accccattga 1509
Tyr Ala Met Phe Gly Leu Ala Ser Leu Ala
455 460
ttc 1512
<210> 630
<211> 463
<212> PRT
<213> Corynebacterium glutamicum
<400> 630
Met Asp Thr Trp Glu Gln Thr Leu Gly Thr Gly Pro Leu Leu Gly Ile
1 5 10 15
Ala Ala Gly Ala Ile Ala Leu Ile Leu Val Leu Val Ile Val Phe Lys
20 25 30
Leu His Ala Phe Leu Thr Leu Ile Leu Val Ser Ile Val Thr Ala Leu
35 40 45
Ala Ala Gly Ile Pro Val Thr Ala Val Val Asp Thr Leu Leu Asp Gly
50 55 60
Phe Gly Lys Thr Leu Ala Ser Val Ala Leu Leu Val Gly Leu Gly Ala
65 70 75 80
Met Leu Gly Arg Leu Val Glu Thr Ser Gly Gly Ala Lys Ser Leu Ala
85 90 95
Asp Thr Met Val Arg Ile Phe Gly Glu Lys Arg Ala Ala Phe Ala Leu
100 105 110
Gly Val Ala Ser Leu Ile Met Gly Phe Pro Ile Phe Phe Asp Ala Gly
115 120 125
Leu Val Val Met Leu Pro Val Ile Phe Ala Val Ala Arg Arg Leu Asn
130 135 140
Gly Ser Val Leu Thr Phe Gly Ile Pro Ala Ala Gly Ala Phe Ser Val
145 150 155 160
Met His Val Phe Val Pro Pro His Pro Gly Pro Ile Ala Ala Ser Glu
165 170 175
Phe Phe Gly Ala Gln Val Gly Tyr Val Leu Ile Ala Gly Ile Ile Val
180 185 190
Ala Leu Pro Thr Trp Tyr Leu Thr Gly Tyr Leu Leu Gly Lys Phe Leu
195 200 205
Gly Arg Lys Phe Pro Leu Pro Val Pro Asp Leu Leu Ser Gly Gly Ala
210 215 220
Gln Glu Asp Asp Gln Pro Gln Asn Pro Ala Asn Ala Val Ser Ile Ile
225 230 235 240
Val Ile Leu Leu Ile Pro Met Leu Leu Ile Phe Gly Asn Thr Gly Thr
245 250 255
Ser Met Ala Val Ser Ala Gly Leu Leu Asp Ala Glu Ser Thr Met Val
260 265 270
Lys Ile Leu Gly Phe Leu Gly Glu Thr Pro Val Ala Leu Leu Ile Thr
275 280 285
Leu Ile Ile Ala Leu Phe Phe Leu Gly Asn Arg Arg Gly Ile Asn Gly
290 295 300
Ser Ala Leu Glu Lys Thr Ile Glu Gly Ala Leu Gly Pro Ile Cys Ser
305 310 315 320
Val Val Leu Ile Thr Gly Ala Gly Gly Met Phe Gly Gly Val Leu Arg
325 330 335
Thr Ser Gly Ile Gly Gly Ala Leu Ala Asp Ser Met Ala Asp Leu Gly
340 345 350
Leu Pro Val Ile Ala Gly Cys Phe Ile Val Ala Ala Val Leu Arg Val
355 360 365
Ala Gln Gly Ser Ala Thr Val Ala Leu Thr Thr Ala Ala Ala Leu Met
370 375 380
Ala Pro Ala Val Ala Ala Ala Asp Phe Asn Glu Phe Gln Leu Ala Ala
385 390 395 400
Ile Val Ile Ser Thr Ala Ala Gly Ser Val Ile Ala Ser His Val Asn
405 410 415
Asp Ser Gly Phe Trp Leu Val Gly Arg Leu Met Asn Ala Asp Val Pro
420 425 430
Thr Thr Leu Lys Thr Trp Thr Val Asn Gln Thr Cys Ile Ala Ile Val
435 440 445
Gly Phe Val Met Ala Tyr Ala Met Phe Gly Leu Ala Ser Leu Ala
450 455 460
<210> 631
<211> 1608
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1585)
<223> RXN00432
<400> 631
agctaatctg ccttgcttta cacctccggg ctataacaat ccagtgccag tggctaggga 60
tttactaaaa atcgggtaac acgcgcgtag tatttttcgc atg gaa tta ttg gag 115
Met Glu Leu Leu Glu
1 5
acc ttc atc act gat gtc att aat gac aat ttg tgg atg atc ttg ccc 163
Thr Phe Ile Thr Asp Val Ile Asn Asp Asn Leu Trp Met Ile Leu Pro
10 15 20
ttc ttg ctc gtt gct gct ggc ctc tat ttc ggt ggg cgt acg ttg ctg 211
Phe Leu Leu Val Ala Ala Gly Leu Tyr Phe Gly Gly Arg Thr Leu Leu
25 30 35
gtt cag att cgg atg att ccg gag atg ttc aaa gcg gtc gtc gag aag 259
Val Gln Ile Arg Met Ile Pro Glu Met Phe Lys Ala Val Val Glu Lys
40 45 50
cct gcg aag gat ggg gag ttc gcg gac aag cag gac att tcg gct ttt 307
Pro Ala Lys Asp Gly Glu Phe Ala Asp Lys Gln Asp Ile Ser Ala Phe
55 60 65
aag gcg ttc acg att tct gcg gcg tcg cga gtt ggt acg gcg aat gtt 355
Lys Ala Phe Thr Ile Ser Ala Ala Ser Arg Val Gly Thr Ala Asn Val
70 75 80 85
gcg ggt gtt gcg ctg gcg atc act ctg ggt gga ccg ggt gca gtg ttc 403
Ala Gly Val Ala Leu Ala Ile Thr Leu Gly Gly Pro Gly Ala Val Phe
90 95 100
tgg atg tgg atc att gcg ctg gtt ggc ggt gcg aca tcg ttc att gag 451
Trp Met Trp Ile Ile Ala Leu Val Gly Gly Ala Thr Ser Phe Ile Glu
105 110 115
tcg act ctt gga cag ttg tgg aag gtg aag gac ggc gac agc tat cgc 499
Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp Gly Asp Ser Tyr Arg
120 125 130
ggt ggc cct gcg tac tac atg acg ctt ggt ttg aat gct cgg tgg ctt 547
Gly Gly Pro Ala Tyr Tyr Met Thr Leu Gly Leu Asn Ala Arg Trp Leu
135 140 145
gcg gtt gtt ttc ggt gtc gcc atc acg ttg acc ttt ggt ttt gtg tac 595
Ala Val Val Phe Gly Val Ala Ile Thr Leu Thr Phe Gly Phe Val Tyr
150 155 160 165
aac gct ttg cag tcc aac gcg gtt gtt gag gcg att acg gta tca ctc 643
Asn Ala Leu Gln Ser Asn Ala Val Val Glu Ala Ile Thr Val Ser Leu
170 175 180
ggc acc cct tct acc act gca aag gct ttt gtt ggc ttg ggc atg gct 691
Gly Thr Pro Ser Thr Thr Ala Lys Ala Phe Val Gly Leu Gly Met Ala
185 190 195
gga ttg tct gcg ctg gtt att ttt ggc ggc gtg cag cgt atc gca aac 739
Gly Leu Ser Ala Leu Val Ile Phe Gly Gly Val Gln Arg Ile Ala Asn
200 205 210
gtg acg cag tgg atg gtt ccg ttc atg gcg ggt gcg tac atc att gtg 787
Val Thr Gln Trp Met Val Pro Phe Met Ala Gly Ala Tyr Ile Ile Val
215 220 225
ggt gtg gtg gtg att gtg att aac att cag cag gtt ccg acc atg atc 835
Gly Val Val Val Ile Val Ile Asn Ile Gln Gln Val Pro Thr Met Ile
230 235 240 245
aac gac atc att gct ggt gct ttt ggt ttc cgt ccg gtt gct act gcg 883
Asn Asp Ile Ile Ala Gly Ala Phe Gly Phe Arg Pro Val Ala Thr Ala
250 255 260
tcg gtg tgg ggc gcg ttc tgg ttg gcg ttt atg aac ggt atg cgc cgt 931
Ser Val Trp Gly Ala Phe Trp Leu Ala Phe Met Asn Gly Met Arg Arg
265 270 275
gga ctg ttc tcc aat gag gct ggt gag ggt tct gtc ccg aac gct gct 979
Gly Leu Phe Ser Asn Glu Ala Gly Glu Gly Ser Val Pro Asn Ala Ala
280 285 290
gct acc gcg act gtg tct cac cct gtg aag cag ggt ttg gtt cag act 1027
Ala Thr Ala Thr Val Ser His Pro Val Lys Gln Gly Leu Val Gln Thr
295 300 305
ctg ggc gta tat ttc gac acc ctg ctc gtt tgt agc att acc gct ttt 1075
Leu Gly Val Tyr Phe Asp Thr Leu Leu Val Cys Ser Ile Thr Ala Phe
310 315 320 325
gtc atc ctg ctg tct gga gtg gag tac gcg acc ggc gat att cag tct 1123
Val Ile Leu Leu Ser Gly Val Glu Tyr Ala Thr Gly Asp Ile Gln Ser
330 335 340
tct tct ttg act cag tcc gcg ctg gct agc gtt gtt ggt ggt tgg gga 1171
Ser Ser Leu Thr Gln Ser Ala Leu Ala Ser Val Val Gly Gly Trp Gly
345 350 355
acc cac ttc att acc gta gtg atg ttc ttc ctg gcg ttt tct tcc gtg 1219
Thr His Phe Ile Thr Val Val Met Phe Phe Leu Ala Phe Ser Ser Val
360 365 370
ctg ggt aac tac tac ttg gca cag gcg aat att cag tac ttc acc gat 1267
Leu Gly Asn Tyr Tyr Leu Ala Gln Ala Asn Ile Gln Tyr Phe Thr Asp
375 380 385
tcg aag act gtc atg act gtt ttc cga ctc ttg gtg ctg ctc agc gtg 1315
Ser Lys Thr Val Met Thr Val Phe Arg Leu Leu Val Leu Leu Ser Val
390 395 400 405
ttc tct ggc gcg gtt gct tcg gtg ccg ttg atc tgg gct ttg ggt gat 1363
Phe Ser Gly Ala Val Ala Ser Val Pro Leu Ile Trp Ala Leu Gly Asp
410 415 420
act ttc gct ggc atc atg gtg ctc att aac ctg gcg gcg atc att ccg 1411
Thr Phe Ala Gly Ile Met Val Leu Ile Asn Leu Ala Ala Ile Ile Pro
425 430 435
ctg ggt ggc gtt gca gtg aag ttg ctt aag aat tac acc att cag aag 1459
Leu Gly Gly Val Ala Val Lys Leu Leu Lys Asn Tyr Thr Ile Gln Lys
440 445 450
aag gct ggt ctg gat cct gtg ttc cac cgc gac atg atg cca gag gtt 1507
Lys Ala Gly Leu Asp Pro Val Phe His Arg Asp Met Met Pro Glu Val
455 460 465
cgt aat att gcg tgc tgg aac ggc aaa gat gca gct aca tcc aac tat 1555
Arg Asn Ile Ala Cys Trp Asn Gly Lys Asp Ala Ala Thr Ser Asn Tyr
470 475 480 485
cac gaa gcg atg gaa gtg atc aag aag agc tagtcatcga aggaacagtg 1605
His Glu Ala Met Glu Val Ile Lys Lys Ser
490 495
gta 1608
<210> 632
<211> 495
<212> PRT
<213> Corynebacterium glutamicum
<400> 632
Met Glu Leu Leu Glu Thr Phe Ile Thr Asp Val Ile Asn Asp Asn Leu
1 5 10 15
Trp Met Ile Leu Pro Phe Leu Leu Val Ala Ala Gly Leu Tyr Phe Gly
20 25 30
Gly Arg Thr Leu Leu Val Gln Ile Arg Met Ile Pro Glu Met Phe Lys
35 40 45
Ala Val Val Glu Lys Pro Ala Lys Asp Gly Glu Phe Ala Asp Lys Gln
50 55 60
Asp Ile Ser Ala Phe Lys Ala Phe Thr Ile Ser Ala Ala Ser Arg Val
65 70 75 80
Gly Thr Ala Asn Val Ala Gly Val Ala Leu Ala Ile Thr Leu Gly Gly
85 90 95
Pro Gly Ala Val Phe Trp Met Trp Ile Ile Ala Leu Val Gly Gly Ala
100 105 110
Thr Ser Phe Ile Glu Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp
115 120 125
Gly Asp Ser Tyr Arg Gly Gly Pro Ala Tyr Tyr Met Thr Leu Gly Leu
130 135 140
Asn Ala Arg Trp Leu Ala Val Val Phe Gly Val Ala Ile Thr Leu Thr
145 150 155 160
Phe Gly Phe Val Tyr Asn Ala Leu Gln Ser Asn Ala Val Val Glu Ala
165 170 175
Ile Thr Val Ser Leu Gly Thr Pro Ser Thr Thr Ala Lys Ala Phe Val
180 185 190
Gly Leu Gly Met Ala Gly Leu Ser Ala Leu Val Ile Phe Gly Gly Val
195 200 205
Gln Arg Ile Ala Asn Val Thr Gln Trp Met Val Pro Phe Met Ala Gly
210 215 220
Ala Tyr Ile Ile Val Gly Val Val Val Ile Val Ile Asn Ile Gln Gln
225 230 235 240
Val Pro Thr Met Ile Asn Asp Ile Ile Ala Gly Ala Phe Gly Phe Arg
245 250 255
Pro Val Ala Thr Ala Ser Val Trp Gly Ala Phe Trp Leu Ala Phe Met
260 265 270
Asn Gly Met Arg Arg Gly Leu Phe Ser Asn Glu Ala Gly Glu Gly Ser
275 280 285
Val Pro Asn Ala Ala Ala Thr Ala Thr Val Ser His Pro Val Lys Gln
290 295 300
Gly Leu Val Gln Thr Leu Gly Val Tyr Phe Asp Thr Leu Leu Val Cys
305 310 315 320
Ser Ile Thr Ala Phe Val Ile Leu Leu Ser Gly Val Glu Tyr Ala Thr
325 330 335
Gly Asp Ile Gln Ser Ser Ser Leu Thr Gln Ser Ala Leu Ala Ser Val
340 345 350
Val Gly Gly Trp Gly Thr His Phe Ile Thr Val Val Met Phe Phe Leu
355 360 365
Ala Phe Ser Ser Val Leu Gly Asn Tyr Tyr Leu Ala Gln Ala Asn Ile
370 375 380
Gln Tyr Phe Thr Asp Ser Lys Thr Val Met Thr Val Phe Arg Leu Leu
385 390 395 400
Val Leu Leu Ser Val Phe Ser Gly Ala Val Ala Ser Val Pro Leu Ile
405 410 415
Trp Ala Leu Gly Asp Thr Phe Ala Gly Ile Met Val Leu Ile Asn Leu
420 425 430
Ala Ala Ile Ile Pro Leu Gly Gly Val Ala Val Lys Leu Leu Lys Asn
435 440 445
Tyr Thr Ile Gln Lys Lys Ala Gly Leu Asp Pro Val Phe His Arg Asp
450 455 460
Met Met Pro Glu Val Arg Asn Ile Ala Cys Trp Asn Gly Lys Asp Ala
465 470 475 480
Ala Thr Ser Asn Tyr His Glu Ala Met Glu Val Ile Lys Lys Ser
485 490 495
<210> 633
<211> 914
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(891)
<223> FRXA00432
<400> 633
ttg tct gcg ctg gtt att ttt ggc ggc gtg cag cgt atc gca aac gtg 48
Leu Ser Ala Leu Val Ile Phe Gly Gly Val Gln Arg Ile Ala Asn Val
1 5 10 15
acg cag tgg atg gtt ccg ttc atg gcg ggt gcg tac atc att gtg ggt 96
Thr Gln Trp Met Val Pro Phe Met Ala Gly Ala Tyr Ile Ile Val Gly
20 25 30
gtg gtg gtg att gtg att aac att cag cag gtt ccg acc atg atc aac 144
Val Val Val Ile Val Ile Asn Ile Gln Gln Val Pro Thr Met Ile Asn
35 40 45
gac atc att gct ggt gct ttt ggt ttc cgt ccg gtt gct act gcg tcg 192
Asp Ile Ile Ala Gly Ala Phe Gly Phe Arg Pro Val Ala Thr Ala Ser
50 55 60
gtg tgg ggc gcg ttc tgg ttg gcg ttt atg aac ggt atg cgc cgt gga 240
Val Trp Gly Ala Phe Trp Leu Ala Phe Met Asn Gly Met Arg Arg Gly
65 70 75 80
ctg ttc tcc aat gag gct ggt gag ggt tct gtc ccg aac gct gct gct 288
Leu Phe Ser Asn Glu Ala Gly Glu Gly Ser Val Pro Asn Ala Ala Ala
85 90 95
acc gcg act gtg tct cac cct gtg aag cag ggt ttg gtt cag act ctg 336
Thr Ala Thr Val Ser His Pro Val Lys Gln Gly Leu Val Gln Thr Leu
100 105 110
ggc gta tat ttc gac acc ctg ctc gtt tgt agc att acc gct ttt gtc 384
Gly Val Tyr Phe Asp Thr Leu Leu Val Cys Ser Ile Thr Ala Phe Val
115 120 125
atc ctg ctg tct gga gtg gag tac gcg acc ggc gat att cag tct tct 432
Ile Leu Leu Ser Gly Val Glu Tyr Ala Thr Gly Asp Ile Gln Ser Ser
130 135 140
tct ttg act cag tcc gcg ctg gct agc gtt gtt ggt ggt tgg gga acc 480
Ser Leu Thr Gln Ser Ala Leu Ala Ser Val Val Gly Gly Trp Gly Thr
145 150 155 160
cac ttc att acc gta gtg atg ttc ttc ctg gcg ttt tct tcc gtg ctg 528
His Phe Ile Thr Val Val Met Phe Phe Leu Ala Phe Ser Ser Val Leu
165 170 175
ggt aac tac tac ttg gca cag gcg aat att cag tac ttc acc gat tcg 576
Gly Asn Tyr Tyr Leu Ala Gln Ala Asn Ile Gln Tyr Phe Thr Asp Ser
180 185 190
aag act gtc atg act gtt ttc cga ctc ttg gtg ctg ctc agc gtg ttc 624
Lys Thr Val Met Thr Val Phe Arg Leu Leu Val Leu Leu Ser Val Phe
195 200 205
tct ggc gcg gtt gct tcg gtg ccg ttg atc tgg gct ttg ggt gat act 672
Ser Gly Ala Val Ala Ser Val Pro Leu Ile Trp Ala Leu Gly Asp Thr
210 215 220
ttc gct ggc atc atg gtg ctc att aac ctg gcg gcg atc att ccg ctg 720
Phe Ala Gly Ile Met Val Leu Ile Asn Leu Ala Ala Ile Ile Pro Leu
225 230 235 240
ggt ggc gtt gca gtg aag ttg ctt aag aat tac acc att cag aag aag 768
Gly Gly Val Ala Val Lys Leu Leu Lys Asn Tyr Thr Ile Gln Lys Lys
245 250 255
gct ggt ctg gat cct gtg ttc cac cgc gac atg atg cca gag gtt cgt 816
Ala Gly Leu Asp Pro Val Phe His Arg Asp Met Met Pro Glu Val Arg
260 265 270
aat att gcg tgc tgg aac ggc aaa gat gca gct aca tcc aac tat cac 864
Asn Ile Ala Cys Trp Asn Gly Lys Asp Ala Ala Thr Ser Asn Tyr His
275 280 285
gaa gcg atg gaa gtg atc aag aag agc tagtcatcga aggaacagtg 911
Glu Ala Met Glu Val Ile Lys Lys Ser
290 295
gta 914
<210> 634
<211> 297
<212> PRT
<213> Corynebacterium glutamicum
<400> 634
Leu Ser Ala Leu Val Ile Phe Gly Gly Val Gln Arg Ile Ala Asn Val
1 5 10 15
Thr Gln Trp Met Val Pro Phe Met Ala Gly Ala Tyr Ile Ile Val Gly
20 25 30
Val Val Val Ile Val Ile Asn Ile Gln Gln Val Pro Thr Met Ile Asn
35 40 45
Asp Ile Ile Ala Gly Ala Phe Gly Phe Arg Pro Val Ala Thr Ala Ser
50 55 60
Val Trp Gly Ala Phe Trp Leu Ala Phe Met Asn Gly Met Arg Arg Gly
65 70 75 80
Leu Phe Ser Asn Glu Ala Gly Glu Gly Ser Val Pro Asn Ala Ala Ala
85 90 95
Thr Ala Thr Val Ser His Pro Val Lys Gln Gly Leu Val Gln Thr Leu
100 105 110
Gly Val Tyr Phe Asp Thr Leu Leu Val Cys Ser Ile Thr Ala Phe Val
115 120 125
Ile Leu Leu Ser Gly Val Glu Tyr Ala Thr Gly Asp Ile Gln Ser Ser
130 135 140
Ser Leu Thr Gln Ser Ala Leu Ala Ser Val Val Gly Gly Trp Gly Thr
145 150 155 160
His Phe Ile Thr Val Val Met Phe Phe Leu Ala Phe Ser Ser Val Leu
165 170 175
Gly Asn Tyr Tyr Leu Ala Gln Ala Asn Ile Gln Tyr Phe Thr Asp Ser
180 185 190
Lys Thr Val Met Thr Val Phe Arg Leu Leu Val Leu Leu Ser Val Phe
195 200 205
Ser Gly Ala Val Ala Ser Val Pro Leu Ile Trp Ala Leu Gly Asp Thr
210 215 220
Phe Ala Gly Ile Met Val Leu Ile Asn Leu Ala Ala Ile Ile Pro Leu
225 230 235 240
Gly Gly Val Ala Val Lys Leu Leu Lys Asn Tyr Thr Ile Gln Lys Lys
245 250 255
Ala Gly Leu Asp Pro Val Phe His Arg Asp Met Met Pro Glu Val Arg
260 265 270
Asn Ile Ala Cys Trp Asn Gly Lys Asp Ala Ala Thr Ser Asn Tyr His
275 280 285
Glu Ala Met Glu Val Ile Lys Lys Ser
290 295
<210> 635
<211> 569
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (45)..(569)
<223> FRXA00436
<400> 635
gggatttact aaaaatcggg taacacgcgc gtagtatttt tcgc atg gaa tta ttg 56
Met Glu Leu Leu
1
gag acc ttc atc act gat gtc att aat gac aat ttg tgg atg atc ttg 104
Glu Thr Phe Ile Thr Asp Val Ile Asn Asp Asn Leu Trp Met Ile Leu
5 10 15 20
ccc ttc ttg ctc gtt gct gct ggc ctc tat ttc ggt ggg cgt acg ttg 152
Pro Phe Leu Leu Val Ala Ala Gly Leu Tyr Phe Gly Gly Arg Thr Leu
25 30 35
ctg gtt cag att cgg atg att ccg gag atg ttc aaa gcg gtc gtc gag 200
Leu Val Gln Ile Arg Met Ile Pro Glu Met Phe Lys Ala Val Val Glu
40 45 50
aag cct gcg aag gat ggg gag ttc gcg gac aag cag gac att tcg gct 248
Lys Pro Ala Lys Asp Gly Glu Phe Ala Asp Lys Gln Asp Ile Ser Ala
55 60 65
ttt aag gcg ttc acg att tct gcg gcg tcg cga gtt ggt acg gcg aat 296
Phe Lys Ala Phe Thr Ile Ser Ala Ala Ser Arg Val Gly Thr Ala Asn
70 75 80
gtt gcg ggt gtt gcg ctg gcg atc act ctg ggt gga ccg ggt gca gtg 344
Val Ala Gly Val Ala Leu Ala Ile Thr Leu Gly Gly Pro Gly Ala Val
85 90 95 100
ttc tgg atg tgg atc att gcg ctg gtt ggc ggt gcg aca tcg ttc att 392
Phe Trp Met Trp Ile Ile Ala Leu Val Gly Gly Ala Thr Ser Phe Ile
105 110 115
gag tcg act ctt gga cag ttg tgg aag gtg aag gac ggc gac agc tat 440
Glu Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp Gly Asp Ser Tyr
120 125 130
cgc ggt ggc cct gcg tac tac atg acg ctt ggt ttg aat gct cgg tgg 488
Arg Gly Gly Pro Ala Tyr Tyr Met Thr Leu Gly Leu Asn Ala Arg Trp
135 140 145
ctt gcg gtt gtt ttc ggt gtc gcc atc acg ttg acc ttt ggt ttt gtg 536
Leu Ala Val Val Phe Gly Val Ala Ile Thr Leu Thr Phe Gly Phe Val
150 155 160
tac aac gct ttg cag tcc aac gcg gtt gtt gag 569
Tyr Asn Ala Leu Gln Ser Asn Ala Val Val Glu
165 170 175
<210> 636
<211> 175
<212> PRT
<213> Corynebacterium glutamicum
<400> 636
Met Glu Leu Leu Glu Thr Phe Ile Thr Asp Val Ile Asn Asp Asn Leu
1 5 10 15
Trp Met Ile Leu Pro Phe Leu Leu Val Ala Ala Gly Leu Tyr Phe Gly
20 25 30
Gly Arg Thr Leu Leu Val Gln Ile Arg Met Ile Pro Glu Met Phe Lys
35 40 45
Ala Val Val Glu Lys Pro Ala Lys Asp Gly Glu Phe Ala Asp Lys Gln
50 55 60
Asp Ile Ser Ala Phe Lys Ala Phe Thr Ile Ser Ala Ala Ser Arg Val
65 70 75 80
Gly Thr Ala Asn Val Ala Gly Val Ala Leu Ala Ile Thr Leu Gly Gly
85 90 95
Pro Gly Ala Val Phe Trp Met Trp Ile Ile Ala Leu Val Gly Gly Ala
100 105 110
Thr Ser Phe Ile Glu Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp
115 120 125
Gly Asp Ser Tyr Arg Gly Gly Pro Ala Tyr Tyr Met Thr Leu Gly Leu
130 135 140
Asn Ala Arg Trp Leu Ala Val Val Phe Gly Val Ala Ile Thr Leu Thr
145 150 155 160
Phe Gly Phe Val Tyr Asn Ala Leu Gln Ser Asn Ala Val Val Glu
165 170 175
<210> 637
<211> 1572
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1549)
<223> RXA00847
<400> 637
tctggcccgc tgtgtcctct ggacgcagcg ggccagtagt attttggggg tgagaataag 60
gtttggaatt ctaagtgttg tcgcctgcac ggtttcgttg gtg gca tgt cag gct 115
Val Ala Cys Gln Ala
1 5
aat ccg ggt cct gcg ccc gtt gag gag cca act aca gcc act gcg acg 163
Asn Pro Gly Pro Ala Pro Val Glu Glu Pro Thr Thr Ala Thr Ala Thr
10 15 20
acc acg gca act gag acg acc acc gta gag act gaa gcc ccc aaa caa 211
Thr Thr Ala Thr Glu Thr Thr Thr Val Glu Thr Glu Ala Pro Lys Gln
25 30 35
gat cgg gaa acc atc agt att ggt atc gat ccg atc cgc aac ggt ttc 259
Asp Arg Glu Thr Ile Ser Ile Gly Ile Asp Pro Ile Arg Asn Gly Phe
40 45 50
aat cca cat ttg ttg tct gat gat tct cca ctg gtg cgc gat act gca 307
Asn Pro His Leu Leu Ser Asp Asp Ser Pro Leu Val Arg Asp Thr Ala
55 60 65
tcg ttg gtg ttg ccg agt gct ttt gag ggc aat cag ctg aac act gac 355
Ser Leu Val Leu Pro Ser Ala Phe Glu Gly Asn Gln Leu Asn Thr Asp
70 75 80 85
ttg ttg gac aat gtt gag cag gtg gat gaa acc acg gtg agg tac acg 403
Leu Leu Asp Asn Val Glu Gln Val Asp Glu Thr Thr Val Arg Tyr Thr
90 95 100
att gct cag gaa gcg cag tgg agt gat ggc act ccg att act ggg tct 451
Ile Ala Gln Glu Ala Gln Trp Ser Asp Gly Thr Pro Ile Thr Gly Ser
105 110 115
gat ttt gag tac ttg cgc agg tcc att gtg gcg ggg aca gga acg ctg 499
Asp Phe Glu Tyr Leu Arg Arg Ser Ile Val Ala Gly Thr Gly Thr Leu
120 125 130
aac gat tct gca tat tcg gcg att tca gag att agg acc tca ggc ggt 547
Asn Asp Ser Ala Tyr Ser Ala Ile Ser Glu Ile Arg Thr Ser Gly Gly
135 140 145
gga aaa act gtc gac gtt att ttt gaa cat cct gtc gct gat tgg cat 595
Gly Lys Thr Val Asp Val Ile Phe Glu His Pro Val Ala Asp Trp His
150 155 160 165
ttg ctg ttt aac aat ttg ttg ccg agt cat ttg atc act ggc aat tcc 643
Leu Leu Phe Asn Asn Leu Leu Pro Ser His Leu Ile Thr Gly Asn Ser
170 175 180
aca ttc cag aca gcg ttt tat gat tcc atc ccg gcc tct gcg ggg cgc 691
Thr Phe Gln Thr Ala Phe Tyr Asp Ser Ile Pro Ala Ser Ala Gly Arg
185 190 195
tac atg gtg cgt tcc att gat cgt cag cgc ggc gtg att acg ttg tcg 739
Tyr Met Val Arg Ser Ile Asp Arg Gln Arg Gly Val Ile Thr Leu Ser
200 205 210
cgc aat gat cgt ttc tgg ggt gca aat ccg gca cac gtg gaa gta ctc 787
Arg Asn Asp Arg Phe Trp Gly Ala Asn Pro Ala His Val Glu Val Leu
215 220 225
caa ttc aac acc gtt gcc tct gca tcc cgg gcg ggg gag tac ctg cgc 835
Gln Phe Asn Thr Val Ala Ser Ala Ser Arg Ala Gly Glu Tyr Leu Arg
230 235 240 245
acc ggg cag agt tcg ttt atg aat ctg tca ccg cag gaa acc ctg gtg 883
Thr Gly Gln Ser Ser Phe Met Asn Leu Ser Pro Gln Glu Thr Leu Val
250 255 260
gac acg ttg aat ttg gtg ccg gac acg gaa gtg cgg gtg tct gac acg 931
Asp Thr Leu Asn Leu Val Pro Asp Thr Glu Val Arg Val Ser Asp Thr
265 270 275
acg cgc acg ctg gag ctg gta ttc aac gcc gaa gcg ctg gca ccg gcg 979
Thr Arg Thr Leu Glu Leu Val Phe Asn Ala Glu Ala Leu Ala Pro Ala
280 285 290
cag cgc gcc tac ctg aca tcg ctt atc gac gtc ccc ctc acc gcc aag 1027
Gln Arg Ala Tyr Leu Thr Ser Leu Ile Asp Val Pro Leu Thr Ala Lys
295 300 305
tta gct ggc ggt cgc agt gca aac ctg ggt gtg ccc caa acg gtg gag 1075
Leu Ala Gly Gly Arg Ser Ala Asn Leu Gly Val Pro Gln Thr Val Glu
310 315 320 325
gcg agc gtc gat aag caa gaa att cct gcg ttg cgc ctg gcg gcg gac 1123
Ala Ser Val Asp Lys Gln Glu Ile Pro Ala Leu Arg Leu Ala Ala Asp
330 335 340
ccc gcc gac gat gct ggt ttg gca gct gcg cgg ggc atc gtc gat atg 1171
Pro Ala Asp Asp Ala Gly Leu Ala Ala Ala Arg Gly Ile Val Asp Met
345 350 355
ctg gct gcg gat gga atc aag gct cag gtc gtg aca acc gat ttg aat 1219
Leu Ala Ala Asp Gly Ile Lys Ala Gln Val Val Thr Thr Asp Leu Asn
360 365 370
tcg gcg att gcg ggt aat ttt gat gcg atc gtg gcg tgg acc aga act 1267
Ser Ala Ile Ala Gly Asn Phe Asp Ala Ile Val Ala Trp Thr Arg Thr
375 380 385
gcc acg gat tcg att gcg ttg gcg gac cga gtg ggt tgt ggc gtg aac 1315
Ala Thr Asp Ser Ile Ala Leu Ala Asp Arg Val Gly Cys Gly Val Asn
390 395 400 405
ttg gca aag tgg tgc gct gag gga acc acg gaa tat atc aac ggt gtt 1363
Leu Ala Lys Trp Cys Ala Glu Gly Thr Thr Glu Tyr Ile Asn Gly Val
410 415 420
ttg gcg ggt gag att gat ttc gat cct gcg tgg gag cag cag ttt aac 1411
Leu Ala Gly Glu Ile Asp Phe Asp Pro Ala Trp Glu Gln Gln Phe Asn
425 430 435
acc gag aat cac ttg cgg gtt ccg atc ctg cgg gag act cgg gta gaa 1459
Thr Glu Asn His Leu Arg Val Pro Ile Leu Arg Glu Thr Arg Val Glu
440 445 450
gcg aaa aat aac ggt atc ctc ggg gct gcg gat ggc tgg cct ggg gga 1507
Ala Lys Asn Asn Gly Ile Leu Gly Ala Ala Asp Gly Trp Pro Gly Gly
455 460 465
att tca agt gct gca agt tgg agg aaa aac gat gtt gaa gaa 1549
Ile Ser Ser Ala Ala Ser Trp Arg Lys Asn Asp Val Glu Glu
470 475 480
tgatctgtct ggtgctcgag ttg 1572
<210> 638
<211> 483
<212> PRT
<213> Corynebacterium glutamicum
<400> 638
Val Ala Cys Gln Ala Asn Pro Gly Pro Ala Pro Val Glu Glu Pro Thr
1 5 10 15
Thr Ala Thr Ala Thr Thr Thr Ala Thr Glu Thr Thr Thr Val Glu Thr
20 25 30
Glu Ala Pro Lys Gln Asp Arg Glu Thr Ile Ser Ile Gly Ile Asp Pro
35 40 45
Ile Arg Asn Gly Phe Asn Pro His Leu Leu Ser Asp Asp Ser Pro Leu
50 55 60
Val Arg Asp Thr Ala Ser Leu Val Leu Pro Ser Ala Phe Glu Gly Asn
65 70 75 80
Gln Leu Asn Thr Asp Leu Leu Asp Asn Val Glu Gln Val Asp Glu Thr
85 90 95
Thr Val Arg Tyr Thr Ile Ala Gln Glu Ala Gln Trp Ser Asp Gly Thr
100 105 110
Pro Ile Thr Gly Ser Asp Phe Glu Tyr Leu Arg Arg Ser Ile Val Ala
115 120 125
Gly Thr Gly Thr Leu Asn Asp Ser Ala Tyr Ser Ala Ile Ser Glu Ile
130 135 140
Arg Thr Ser Gly Gly Gly Lys Thr Val Asp Val Ile Phe Glu His Pro
145 150 155 160
Val Ala Asp Trp His Leu Leu Phe Asn Asn Leu Leu Pro Ser His Leu
165 170 175
Ile Thr Gly Asn Ser Thr Phe Gln Thr Ala Phe Tyr Asp Ser Ile Pro
180 185 190
Ala Ser Ala Gly Arg Tyr Met Val Arg Ser Ile Asp Arg Gln Arg Gly
195 200 205
Val Ile Thr Leu Ser Arg Asn Asp Arg Phe Trp Gly Ala Asn Pro Ala
210 215 220
His Val Glu Val Leu Gln Phe Asn Thr Val Ala Ser Ala Ser Arg Ala
225 230 235 240
Gly Glu Tyr Leu Arg Thr Gly Gln Ser Ser Phe Met Asn Leu Ser Pro
245 250 255
Gln Glu Thr Leu Val Asp Thr Leu Asn Leu Val Pro Asp Thr Glu Val
260 265 270
Arg Val Ser Asp Thr Thr Arg Thr Leu Glu Leu Val Phe Asn Ala Glu
275 280 285
Ala Leu Ala Pro Ala Gln Arg Ala Tyr Leu Thr Ser Leu Ile Asp Val
290 295 300
Pro Leu Thr Ala Lys Leu Ala Gly Gly Arg Ser Ala Asn Leu Gly Val
305 310 315 320
Pro Gln Thr Val Glu Ala Ser Val Asp Lys Gln Glu Ile Pro Ala Leu
325 330 335
Arg Leu Ala Ala Asp Pro Ala Asp Asp Ala Gly Leu Ala Ala Ala Arg
340 345 350
Gly Ile Val Asp Met Leu Ala Ala Asp Gly Ile Lys Ala Gln Val Val
355 360 365
Thr Thr Asp Leu Asn Ser Ala Ile Ala Gly Asn Phe Asp Ala Ile Val
370 375 380
Ala Trp Thr Arg Thr Ala Thr Asp Ser Ile Ala Leu Ala Asp Arg Val
385 390 395 400
Gly Cys Gly Val Asn Leu Ala Lys Trp Cys Ala Glu Gly Thr Thr Glu
405 410 415
Tyr Ile Asn Gly Val Leu Ala Gly Glu Ile Asp Phe Asp Pro Ala Trp
420 425 430
Glu Gln Gln Phe Asn Thr Glu Asn His Leu Arg Val Pro Ile Leu Arg
435 440 445
Glu Thr Arg Val Glu Ala Lys Asn Asn Gly Ile Leu Gly Ala Ala Asp
450 455 460
Gly Trp Pro Gly Gly Ile Ser Ser Ala Ala Ser Trp Arg Lys Asn Asp
465 470 475 480
Val Glu Glu
<210> 639
<211> 1192
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1192)
<223> RXN01382
<400> 639
aaaggatgta cctcatgagc accacgatta ctcgccgcaa tttcctccga gcaaccggaa 60
tcctcggtgt cgcagctggc atcggcgcaa cacttgctgc atg tgc acc aac aac 115
Met Cys Thr Asn Asn
1 5
acc ggc acc agc gga tcc acc tcc acc gca gct ggc acc gga act gca 163
Thr Gly Thr Ser Gly Ser Thr Ser Thr Ala Ala Gly Thr Gly Thr Ala
10 15 20
aat gaa gaa ggc acc atc acc gca gcc atc tcc tac gaa ctg gga acc 211
Asn Glu Glu Gly Thr Ile Thr Ala Ala Ile Ser Tyr Glu Leu Gly Thr
25 30 35
aac ggc tac gac cca atg acc acc acc tcg gct ctc act gtg gca gcc 259
Asn Gly Tyr Asp Pro Met Thr Thr Thr Ser Ala Leu Thr Val Ala Ala
40 45 50
aac tgg cac acc ctt gaa ggc ctc acc gaa atc gac cca gcc acc ggc 307
Asn Trp His Thr Leu Glu Gly Leu Thr Glu Ile Asp Pro Ala Thr Gly
55 60 65
gag gtc tac gca gca ctc gcc agc gca ctg cct tca gcc gat gcg acc 355
Glu Val Tyr Ala Ala Leu Ala Ser Ala Leu Pro Ser Ala Asp Ala Thr
70 75 80 85
tcc cta gac atc aag ctt cgc gac ggc gcc acc ttc cac aac ggc gac 403
Ser Leu Asp Ile Lys Leu Arg Asp Gly Ala Thr Phe His Asn Gly Asp
90 95 100
gca gtc acc gca gac gac gta gtc ttc tct ttt gag cga gtc ctc gat 451
Ala Val Thr Ala Asp Asp Val Val Phe Ser Phe Glu Arg Val Leu Asp
105 110 115
cca gcc aac aac tcc ctt tac gca tcc ttc atc cca ttc atc aag tca 499
Pro Ala Asn Asn Ser Leu Tyr Ala Ser Phe Ile Pro Phe Ile Lys Ser
120 125 130
gtc acc aag aag gat gac acc acc gtc acc atc gac ctc gac tac gca 547
Val Thr Lys Lys Asp Asp Thr Thr Val Thr Ile Asp Leu Asp Tyr Ala
135 140 145
acc ggc atc atc agc gaa cgc ctc gca gta gta aag atc gtg cca aag 595
Thr Gly Ile Ile Ser Glu Arg Leu Ala Val Val Lys Ile Val Pro Lys
150 155 160 165
tcc gtc gtg gaa gca gac gca tcc gga ttc gac gcc aac cca atc ggc 643
Ser Val Val Glu Ala Asp Ala Ser Gly Phe Asp Ala Asn Pro Ile Gly
170 175 180
tcc ggc cca tac aag atg acc gac aac ggt gca tcc aag gtg gtc aag 691
Ser Gly Pro Tyr Lys Met Thr Asp Asn Gly Ala Ser Lys Val Val Lys
185 190 195
ttc gag cgc aac gac gac tac aac ggc cca cgc cca gca cgt gcc gcc 739
Phe Glu Arg Asn Asp Asp Tyr Asn Gly Pro Arg Pro Ala Arg Ala Ala
200 205 210
aag atg gaa tgg cag atc atc ccc gac gcc tcc acc cgc acc aac tcc 787
Lys Met Glu Trp Gln Ile Ile Pro Asp Ala Ser Thr Arg Thr Asn Ser
215 220 225
ctt cag tcc ggc agc acc atg gcc atc gac tcc gtt cca tac ctg tcg 835
Leu Gln Ser Gly Ser Thr Met Ala Ile Asp Ser Val Pro Tyr Leu Ser
230 235 240 245
atc cca cag ctt gaa gcc acc agc acc gta gaa tcc gtc caa gga ttc 883
Ile Pro Gln Leu Glu Ala Thr Ser Thr Val Glu Ser Val Gln Gly Phe
250 255 260
ggc ctc ctg ttc gcc atg ttc agc tgc tcc gaa ggc aac ccc ttc aac 931
Gly Leu Leu Phe Ala Met Phe Ser Cys Ser Glu Gly Asn Pro Phe Asn
265 270 275
gac gtc cgc aac cgc cag gca ttc ctc tac gca ctg gac atg gac aag 979
Asp Val Arg Asn Arg Gln Ala Phe Leu Tyr Ala Leu Asp Met Asp Lys
280 285 290
atc gtt aag acc ggc atg tcc gac cag gca acc cca gcc acc tcc ttc 1027
Ile Val Lys Thr Gly Met Ser Asp Gln Ala Thr Pro Ala Thr Ser Phe
295 300 305
gtg cag aag gaa cac ccc aac tac aac cag gca tcc acg gtc tac tcc 1075
Val Gln Lys Glu His Pro Asn Tyr Asn Gln Ala Ser Thr Val Tyr Ser
310 315 320 325
ctc gac gcc gac aaa gcc aag gcg ctg ttc gct gaa acc ggc ctt acc 1123
Leu Asp Ala Asp Lys Ala Lys Ala Leu Phe Ala Glu Thr Gly Leu Thr
330 335 340
agc ctc aac ctc ctg tgc acc gac cac gac tgg gtc aag aac tgc acc 1171
Ser Leu Asn Leu Leu Cys Thr Asp His Asp Trp Val Lys Asn Cys Thr
345 350 355
cca ctg atc cag gaa tcc ctc 1192
Pro Leu Ile Gln Glu Ser Leu
360
<210> 640
<211> 364
<212> PRT
<213> Corynebacterium glutamicum
<400> 640
Met Cys Thr Asn Asn Thr Gly Thr Ser Gly Ser Thr Ser Thr Ala Ala
1 5 10 15
Gly Thr Gly Thr Ala Asn Glu Glu Gly Thr Ile Thr Ala Ala Ile Ser
20 25 30
Tyr Glu Leu Gly Thr Asn Gly Tyr Asp Pro Met Thr Thr Thr Ser Ala
35 40 45
Leu Thr Val Ala Ala Asn Trp His Thr Leu Glu Gly Leu Thr Glu Ile
50 55 60
Asp Pro Ala Thr Gly Glu Val Tyr Ala Ala Leu Ala Ser Ala Leu Pro
65 70 75 80
Ser Ala Asp Ala Thr Ser Leu Asp Ile Lys Leu Arg Asp Gly Ala Thr
85 90 95
Phe His Asn Gly Asp Ala Val Thr Ala Asp Asp Val Val Phe Ser Phe
100 105 110
Glu Arg Val Leu Asp Pro Ala Asn Asn Ser Leu Tyr Ala Ser Phe Ile
115 120 125
Pro Phe Ile Lys Ser Val Thr Lys Lys Asp Asp Thr Thr Val Thr Ile
130 135 140
Asp Leu Asp Tyr Ala Thr Gly Ile Ile Ser Glu Arg Leu Ala Val Val
145 150 155 160
Lys Ile Val Pro Lys Ser Val Val Glu Ala Asp Ala Ser Gly Phe Asp
165 170 175
Ala Asn Pro Ile Gly Ser Gly Pro Tyr Lys Met Thr Asp Asn Gly Ala
180 185 190
Ser Lys Val Val Lys Phe Glu Arg Asn Asp Asp Tyr Asn Gly Pro Arg
195 200 205
Pro Ala Arg Ala Ala Lys Met Glu Trp Gln Ile Ile Pro Asp Ala Ser
210 215 220
Thr Arg Thr Asn Ser Leu Gln Ser Gly Ser Thr Met Ala Ile Asp Ser
225 230 235 240
Val Pro Tyr Leu Ser Ile Pro Gln Leu Glu Ala Thr Ser Thr Val Glu
245 250 255
Ser Val Gln Gly Phe Gly Leu Leu Phe Ala Met Phe Ser Cys Ser Glu
260 265 270
Gly Asn Pro Phe Asn Asp Val Arg Asn Arg Gln Ala Phe Leu Tyr Ala
275 280 285
Leu Asp Met Asp Lys Ile Val Lys Thr Gly Met Ser Asp Gln Ala Thr
290 295 300
Pro Ala Thr Ser Phe Val Gln Lys Glu His Pro Asn Tyr Asn Gln Ala
305 310 315 320
Ser Thr Val Tyr Ser Leu Asp Ala Asp Lys Ala Lys Ala Leu Phe Ala
325 330 335
Glu Thr Gly Leu Thr Ser Leu Asn Leu Leu Cys Thr Asp His Asp Trp
340 345 350
Val Lys Asn Cys Thr Pro Leu Ile Gln Glu Ser Leu
355 360
<210> 641
<211> 1062
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(1062)
<223> FRXA01382
<400> 641
tcc acc tcc acc gca gct ggc acc gga act gca aat gaa gaa ggc acc 48
Ser Thr Ser Thr Ala Ala Gly Thr Gly Thr Ala Asn Glu Glu Gly Thr
1 5 10 15
atc acc gca gcc atc tcc tac gaa ctg gga acc aac ggc tac gac cca 96
Ile Thr Ala Ala Ile Ser Tyr Glu Leu Gly Thr Asn Gly Tyr Asp Pro
20 25 30
atg acc acc acc tcg gct ctc act gtg gca gcc aac tgg cac acc ctt 144
Met Thr Thr Thr Ser Ala Leu Thr Val Ala Ala Asn Trp His Thr Leu
35 40 45
gaa ggc ctc acc gaa atc gac cca gcc acc ggc gag gtc tac gca gca 192
Glu Gly Leu Thr Glu Ile Asp Pro Ala Thr Gly Glu Val Tyr Ala Ala
50 55 60
ctc gcc agc gca ctg cct tca gcc gat gcg acc tcc cta gac atc aag 240
Leu Ala Ser Ala Leu Pro Ser Ala Asp Ala Thr Ser Leu Asp Ile Lys
65 70 75 80
ctt cgc gac ggc gcc acc ttc cac aac ggc gac gca gtc acc gca gac 288
Leu Arg Asp Gly Ala Thr Phe His Asn Gly Asp Ala Val Thr Ala Asp
85 90 95
gac gta gtc ttc tct ttt gag cga gtc ctc gat cca gcc aac aac tcc 336
Asp Val Val Phe Ser Phe Glu Arg Val Leu Asp Pro Ala Asn Asn Ser
100 105 110
ctt tac gca tcc ttc atc cca ttc atc aag tca gtc acc aag aag gat 384
Leu Tyr Ala Ser Phe Ile Pro Phe Ile Lys Ser Val Thr Lys Lys Asp
115 120 125
gac acc acc gtc acc atc gac ctc gac tac gca acc ggc atc atc agc 432
Asp Thr Thr Val Thr Ile Asp Leu Asp Tyr Ala Thr Gly Ile Ile Ser
130 135 140
gaa cgc ctc gca gta gta aag atc gtg cca aag tcc gtc gtg gaa gca 480
Glu Arg Leu Ala Val Val Lys Ile Val Pro Lys Ser Val Val Glu Ala
145 150 155 160
gac gca tcc gga ttc gac gcc aac cca atc ggc tcc ggc cca tac aag 528
Asp Ala Ser Gly Phe Asp Ala Asn Pro Ile Gly Ser Gly Pro Tyr Lys
165 170 175
atg acc gac aac ggt gca tcc aag gtg gtc aag ttc gag cgc aac gac 576
Met Thr Asp Asn Gly Ala Ser Lys Val Val Lys Phe Glu Arg Asn Asp
180 185 190
gac tac aac ggc cca cgc cca gca cgt gcc gcc aag atg gaa tgg cag 624
Asp Tyr Asn Gly Pro Arg Pro Ala Arg Ala Ala Lys Met Glu Trp Gln
195 200 205
atc atc ccc gac gcc tcc acc cgc acc aac tcc ctt cag tcc ggc agc 672
Ile Ile Pro Asp Ala Ser Thr Arg Thr Asn Ser Leu Gln Ser Gly Ser
210 215 220
acc atg gcc atc gac tcc gtt cca tac ctg tcg atc cca cag ctt gaa 720
Thr Met Ala Ile Asp Ser Val Pro Tyr Leu Ser Ile Pro Gln Leu Glu
225 230 235 240
gcc acc agc acc gta gaa tcc gtc caa gga ttc ggc ctc ctg ttc gcc 768
Ala Thr Ser Thr Val Glu Ser Val Gln Gly Phe Gly Leu Leu Phe Ala
245 250 255
atg ttc agc tgc tcc gaa ggc aac ccc ttc aac gac gtc cgc aac cgc 816
Met Phe Ser Cys Ser Glu Gly Asn Pro Phe Asn Asp Val Arg Asn Arg
260 265 270
cag gca ttc ctc tac gca ctg gac atg gac aag atc gtt aag acc ggc 864
Gln Ala Phe Leu Tyr Ala Leu Asp Met Asp Lys Ile Val Lys Thr Gly
275 280 285
atg tcc gac cag gca acc cca gcc acc tcc ttc gtg cag aag gaa cac 912
Met Ser Asp Gln Ala Thr Pro Ala Thr Ser Phe Val Gln Lys Glu His
290 295 300
ccc aac tac aac cag gca tcc acg gtc tac tcc ctc gac gcc gac aaa 960
Pro Asn Tyr Asn Gln Ala Ser Thr Val Tyr Ser Leu Asp Ala Asp Lys
305 310 315 320
gcc aag gcg ctg ttc gct gaa acc ggc ctt acc agc ctc aac ctc ctg 1008
Ala Lys Ala Leu Phe Ala Glu Thr Gly Leu Thr Ser Leu Asn Leu Leu
325 330 335
tgc acc gac cac gac tgg gtc aag aac tgc acc cca ctg atc cag gaa 1056
Cys Thr Asp His Asp Trp Val Lys Asn Cys Thr Pro Leu Ile Gln Glu
340 345 350
tcc ctc 1062
Ser Leu
<210> 642
<211> 354
<212> PRT
<213> Corynebacterium glutamicum
<400> 642
Ser Thr Ser Thr Ala Ala Gly Thr Gly Thr Ala Asn Glu Glu Gly Thr
1 5 10 15
Ile Thr Ala Ala Ile Ser Tyr Glu Leu Gly Thr Asn Gly Tyr Asp Pro
20 25 30
Met Thr Thr Thr Ser Ala Leu Thr Val Ala Ala Asn Trp His Thr Leu
35 40 45
Glu Gly Leu Thr Glu Ile Asp Pro Ala Thr Gly Glu Val Tyr Ala Ala
50 55 60
Leu Ala Ser Ala Leu Pro Ser Ala Asp Ala Thr Ser Leu Asp Ile Lys
65 70 75 80
Leu Arg Asp Gly Ala Thr Phe His Asn Gly Asp Ala Val Thr Ala Asp
85 90 95
Asp Val Val Phe Ser Phe Glu Arg Val Leu Asp Pro Ala Asn Asn Ser
100 105 110
Leu Tyr Ala Ser Phe Ile Pro Phe Ile Lys Ser Val Thr Lys Lys Asp
115 120 125
Asp Thr Thr Val Thr Ile Asp Leu Asp Tyr Ala Thr Gly Ile Ile Ser
130 135 140
Glu Arg Leu Ala Val Val Lys Ile Val Pro Lys Ser Val Val Glu Ala
145 150 155 160
Asp Ala Ser Gly Phe Asp Ala Asn Pro Ile Gly Ser Gly Pro Tyr Lys
165 170 175
Met Thr Asp Asn Gly Ala Ser Lys Val Val Lys Phe Glu Arg Asn Asp
180 185 190
Asp Tyr Asn Gly Pro Arg Pro Ala Arg Ala Ala Lys Met Glu Trp Gln
195 200 205
Ile Ile Pro Asp Ala Ser Thr Arg Thr Asn Ser Leu Gln Ser Gly Ser
210 215 220
Thr Met Ala Ile Asp Ser Val Pro Tyr Leu Ser Ile Pro Gln Leu Glu
225 230 235 240
Ala Thr Ser Thr Val Glu Ser Val Gln Gly Phe Gly Leu Leu Phe Ala
245 250 255
Met Phe Ser Cys Ser Glu Gly Asn Pro Phe Asn Asp Val Arg Asn Arg
260 265 270
Gln Ala Phe Leu Tyr Ala Leu Asp Met Asp Lys Ile Val Lys Thr Gly
275 280 285
Met Ser Asp Gln Ala Thr Pro Ala Thr Ser Phe Val Gln Lys Glu His
290 295 300
Pro Asn Tyr Asn Gln Ala Ser Thr Val Tyr Ser Leu Asp Ala Asp Lys
305 310 315 320
Ala Lys Ala Leu Phe Ala Glu Thr Gly Leu Thr Ser Leu Asn Leu Leu
325 330 335
Cys Thr Asp His Asp Trp Val Lys Asn Cys Thr Pro Leu Ile Gln Glu
340 345 350
Ser Leu
<210> 643
<211> 335
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(312)
<223> RXA02659
<400> 643
ttc ggc aac gac cca gac ctc ctc atg cgc tgg tgg tac gcc ggc gac 48
Phe Gly Asn Asp Pro Asp Leu Leu Met Arg Trp Trp Tyr Ala Gly Asp
1 5 10 15
gtc tgg acc gac tcc cgc atg cac tgg aag ggc agc gaa tcc tac gac 96
Val Trp Thr Asp Ser Arg Met His Trp Lys Gly Ser Glu Ser Tyr Asp
20 25 30
cag gta caa aac ctc ctg gaa gaa ggc atc cgc gct acc gac aag gca 144
Gln Val Gln Asn Leu Leu Glu Glu Gly Ile Arg Ala Thr Asp Lys Ala
35 40 45
gaa cag caa gac atc tgg aac cgc acc ttc gat gtc atc tcc gac aat 192
Glu Gln Gln Asp Ile Trp Asn Arg Thr Phe Asp Val Ile Ser Asp Asn
50 55 60
gtt ccc ctc tac ccg ctg ttc cac cgc aag gtc cca acc gca tgg aac 240
Val Pro Leu Tyr Pro Leu Phe His Arg Lys Val Pro Thr Ala Trp Asn
65 70 75 80
tcc aac gcc ctc gtc gac ttc aag cca atc tca ctc acc ggc ttg aac 288
Ser Asn Ala Leu Val Asp Phe Lys Pro Ile Ser Leu Thr Gly Leu Asn
85 90 95
ttc tca ggt gtt gca act act gaa taacaacccc agtggctttc aaa 335
Phe Ser Gly Val Ala Thr Thr Glu
100
<210> 644
<211> 104
<212> PRT
<213> Corynebacterium glutamicum
<400> 644
Phe Gly Asn Asp Pro Asp Leu Leu Met Arg Trp Trp Tyr Ala Gly Asp
1 5 10 15
Val Trp Thr Asp Ser Arg Met His Trp Lys Gly Ser Glu Ser Tyr Asp
20 25 30
Gln Val Gln Asn Leu Leu Glu Glu Gly Ile Arg Ala Thr Asp Lys Ala
35 40 45
Glu Gln Gln Asp Ile Trp Asn Arg Thr Phe Asp Val Ile Ser Asp Asn
50 55 60
Val Pro Leu Tyr Pro Leu Phe His Arg Lys Val Pro Thr Ala Trp Asn
65 70 75 80
Ser Asn Ala Leu Val Asp Phe Lys Pro Ile Ser Leu Thr Gly Leu Asn
85 90 95
Phe Ser Gly Val Ala Thr Thr Glu
100
<210> 645
<211> 933
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(910)
<223> RXN02933
<400> 645
tgatctgctg tatcaggtgg ttgatccaag agtcggtgct gttggggttg ctagcactaa 60
ggttccaggg agcgtggctt aagtgacaac gatcaaaaac atg ccc ctt tca ggg 115
Met Pro Leu Ser Gly
1 5
aaa atc ggc ggc ttc atc gtt gcc gtt gta ttt gtt ctt gct gcg ctg 163
Lys Ile Gly Gly Phe Ile Val Ala Val Val Phe Val Leu Ala Ala Leu
10 15 20
tct ttc att tgg act ccg ttt gat cca gtt caa gct ttc cca cag gag 211
Ser Phe Ile Trp Thr Pro Phe Asp Pro Val Gln Ala Phe Pro Gln Glu
25 30 35
cgc ctt gag gga agt tct ttg agg cac ctg ttg gga acg gat cgt tat 259
Arg Leu Glu Gly Ser Ser Leu Arg His Leu Leu Gly Thr Asp Arg Tyr
40 45 50
ggt cgc gat gtt tta tcc cag atc atg gtt ggt tcc cgc gtc acg ttg 307
Gly Arg Asp Val Leu Ser Gln Ile Met Val Gly Ser Arg Val Thr Leu
55 60 65
ttg gtg ggc atc att gcg gtg gcg atc gca gca tta atc ggc acg cca 355
Leu Val Gly Ile Ile Ala Val Ala Ile Ala Ala Leu Ile Gly Thr Pro
70 75 80 85
ctg ggt att gct gcg gga atg cgc cgt ggc atg gtg gaa acc ttt gtc 403
Leu Gly Ile Ala Ala Gly Met Arg Arg Gly Met Val Glu Thr Phe Val
90 95 100
atg cgt ggt gcc gat tta atg ttg gcg ttc cca gca ctg ttg ttg gcg 451
Met Arg Gly Ala Asp Leu Met Leu Ala Phe Pro Ala Leu Leu Leu Ala
105 110 115
att att tcc ggc gcc gtt ttc ggc gcc tcc acg tgg tcc gcg atg gtc 499
Ile Ile Ser Gly Ala Val Phe Gly Ala Ser Thr Trp Ser Ala Met Val
120 125 130
gcg atc ggc atc gca ggc atc cct agt ttt gcc cgc gtg gct cgt gca 547
Ala Ile Gly Ile Ala Gly Ile Pro Ser Phe Ala Arg Val Ala Arg Ala
135 140 145
ggc aca ttg cag gtg acc agt cag gat ttc atc gca gct gct cgg cta 595
Gly Thr Leu Gln Val Thr Ser Gln Asp Phe Ile Ala Ala Ala Arg Leu
150 155 160 165
tca aaa gta agt tcc gcc cgg atc gcg ctt cgc cat att ttg ccc aac 643
Ser Lys Val Ser Ser Ala Arg Ile Ala Leu Arg His Ile Leu Pro Asn
170 175 180
atc acc agc atg ttg atc gtt cag gca tca gta gct ttt gcc ctg gcg 691
Ile Thr Ser Met Leu Ile Val Gln Ala Ser Val Ala Phe Ala Leu Ala
185 190 195
atc ctg gcg gaa gcc gca ttg agt ttc ctc ggt ttg ggc acc act ccc 739
Ile Leu Ala Glu Ala Ala Leu Ser Phe Leu Gly Leu Gly Thr Thr Pro
200 205 210
ccg gat ccc agc tgg ggt cgc atg ttg caa acc gct caa gca tcc atc 787
Pro Asp Pro Ser Trp Gly Arg Met Leu Gln Thr Ala Gln Ala Ser Ile
215 220 225
ggc gtc acc ccc atg ttg gcg gtg tgg ccc ggt gct gcg atc gct ttg 835
Gly Val Thr Pro Met Leu Ala Val Trp Pro Gly Ala Ala Ile Ala Leu
230 235 240 245
acg gtc ctt ggt ttt aat ctt ttc ggt gat ggt tta cgc gat gcc atc 883
Thr Val Leu Gly Phe Asn Leu Phe Gly Asp Gly Leu Arg Asp Ala Ile
250 255 260
gat cca aag cgg gag gtc ggc cgt gct taaagtttct gatttaacgg 930
Asp Pro Lys Arg Glu Val Gly Arg Ala
265 270
ttg 933
<210> 646
<211> 270
<212> PRT
<213> Corynebacterium glutamicum
<400> 646
Met Pro Leu Ser Gly Lys Ile Gly Gly Phe Ile Val Ala Val Val Phe
1 5 10 15
Val Leu Ala Ala Leu Ser Phe Ile Trp Thr Pro Phe Asp Pro Val Gln
20 25 30
Ala Phe Pro Gln Glu Arg Leu Glu Gly Ser Ser Leu Arg His Leu Leu
35 40 45
Gly Thr Asp Arg Tyr Gly Arg Asp Val Leu Ser Gln Ile Met Val Gly
50 55 60
Ser Arg Val Thr Leu Leu Val Gly Ile Ile Ala Val Ala Ile Ala Ala
65 70 75 80
Leu Ile Gly Thr Pro Leu Gly Ile Ala Ala Gly Met Arg Arg Gly Met
85 90 95
Val Glu Thr Phe Val Met Arg Gly Ala Asp Leu Met Leu Ala Phe Pro
100 105 110
Ala Leu Leu Leu Ala Ile Ile Ser Gly Ala Val Phe Gly Ala Ser Thr
115 120 125
Trp Ser Ala Met Val Ala Ile Gly Ile Ala Gly Ile Pro Ser Phe Ala
130 135 140
Arg Val Ala Arg Ala Gly Thr Leu Gln Val Thr Ser Gln Asp Phe Ile
145 150 155 160
Ala Ala Ala Arg Leu Ser Lys Val Ser Ser Ala Arg Ile Ala Leu Arg
165 170 175
His Ile Leu Pro Asn Ile Thr Ser Met Leu Ile Val Gln Ala Ser Val
180 185 190
Ala Phe Ala Leu Ala Ile Leu Ala Glu Ala Ala Leu Ser Phe Leu Gly
195 200 205
Leu Gly Thr Thr Pro Pro Asp Pro Ser Trp Gly Arg Met Leu Gln Thr
210 215 220
Ala Gln Ala Ser Ile Gly Val Thr Pro Met Leu Ala Val Trp Pro Gly
225 230 235 240
Ala Ala Ile Ala Leu Thr Val Leu Gly Phe Asn Leu Phe Gly Asp Gly
245 250 255
Leu Arg Asp Ala Ile Asp Pro Lys Arg Glu Val Gly Arg Ala
260 265 270
<210> 647
<211> 715
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(715)
<223> RXN02991
<400> 647
ttgtcgtgtt cgcgatcttc gccgttggct tcatgattct gaccctgcct atgggccttg 60
gcttgggcaa actctctgag cgtttggcgg tgaagaagta atg gct aat aca gtt 115
Met Ala Asn Thr Val
1 5
cgc gca aca gtc ctc tac gat gct cct gga cca aag ggc cgt cga ttc 163
Arg Ala Thr Val Leu Tyr Asp Ala Pro Gly Pro Lys Gly Arg Arg Phe
10 15 20
aac ctc ata atc acc att ctc acg gtg gtt ctg gga ttg gcg ctc ctc 211
Asn Leu Ile Ile Thr Ile Leu Thr Val Val Leu Gly Leu Ala Leu Leu
25 30 35
ttc tgg att ggc tcc atg ctt tca ggc aac ggc caa ctc gat gcc aac 259
Phe Trp Ile Gly Ser Met Leu Ser Gly Asn Gly Gln Leu Asp Ala Asn
40 45 50
aaa tgg act ccg ttc atc aat tcc caa acc tgg acc acc tac att ctt 307
Lys Trp Thr Pro Phe Ile Asn Ser Gln Thr Trp Thr Thr Tyr Ile Leu
55 60 65
cct ggt ttg tgg ggc acg ctg aaa tct gcc gtg ttc tcg gtg atc ttg 355
Pro Gly Leu Trp Gly Thr Leu Lys Ser Ala Val Phe Ser Val Ile Leu
70 75 80 85
gct ctg gtc atg ggt acc gca ctg ggt ctt ggc cgt atc tct gaa atc 403
Ala Leu Val Met Gly Thr Ala Leu Gly Leu Gly Arg Ile Ser Glu Ile
90 95 100
agg att ctc cgc tgg ttc tgc gcc gtc atc atc gag act ttc cga gcc 451
Arg Ile Leu Arg Trp Phe Cys Ala Val Ile Ile Glu Thr Phe Arg Ala
105 110 115
att ccg gtt ctg atc ctc atg att ttc gcc tac cag atg ttc gcc cag 499
Ile Pro Val Leu Ile Leu Met Ile Phe Ala Tyr Gln Met Phe Ala Gln
120 125 130
tac aac atc gtg ccg tcg agc cag ctc gcg ttc gcc gcc gtg gta ttc 547
Tyr Asn Ile Val Pro Ser Ser Gln Leu Ala Phe Ala Ala Val Val Phe
135 140 145
ggt ctg acc atg tac aac ggt tct gtg atc gca gag att ctg cgt tct 595
Gly Leu Thr Met Tyr Asn Gly Ser Val Ile Ala Glu Ile Leu Arg Ser
150 155 160 165
ggt atc gct tcc ctg cct aag ggg cag aag gaa gca gcg att gcg ttg 643
Gly Ile Ala Ser Leu Pro Lys Gly Gln Lys Glu Ala Ala Ile Ala Leu
170 175 180
ggt atg tct tct agg caa acc acc tgg tca atc ttg ttg cct cag gcc 691
Gly Met Ser Ser Arg Gln Thr Thr Trp Ser Ile Leu Leu Pro Gln Ala
185 190 195
gtg gct gca atg ctc cca gcg ttg 715
Val Ala Ala Met Leu Pro Ala Leu
200 205
<210> 648
<211> 205
<212> PRT
<213> Corynebacterium glutamicum
<400> 648
Met Ala Asn Thr Val Arg Ala Thr Val Leu Tyr Asp Ala Pro Gly Pro
1 5 10 15
Lys Gly Arg Arg Phe Asn Leu Ile Ile Thr Ile Leu Thr Val Val Leu
20 25 30
Gly Leu Ala Leu Leu Phe Trp Ile Gly Ser Met Leu Ser Gly Asn Gly
35 40 45
Gln Leu Asp Ala Asn Lys Trp Thr Pro Phe Ile Asn Ser Gln Thr Trp
50 55 60
Thr Thr Tyr Ile Leu Pro Gly Leu Trp Gly Thr Leu Lys Ser Ala Val
65 70 75 80
Phe Ser Val Ile Leu Ala Leu Val Met Gly Thr Ala Leu Gly Leu Gly
85 90 95
Arg Ile Ser Glu Ile Arg Ile Leu Arg Trp Phe Cys Ala Val Ile Ile
100 105 110
Glu Thr Phe Arg Ala Ile Pro Val Leu Ile Leu Met Ile Phe Ala Tyr
115 120 125
Gln Met Phe Ala Gln Tyr Asn Ile Val Pro Ser Ser Gln Leu Ala Phe
130 135 140
Ala Ala Val Val Phe Gly Leu Thr Met Tyr Asn Gly Ser Val Ile Ala
145 150 155 160
Glu Ile Leu Arg Ser Gly Ile Ala Ser Leu Pro Lys Gly Gln Lys Glu
165 170 175
Ala Ala Ile Ala Leu Gly Met Ser Ser Arg Gln Thr Thr Trp Ser Ile
180 185 190
Leu Leu Pro Gln Ala Val Ala Ala Met Leu Pro Ala Leu
195 200 205
<210> 649
<211> 245
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(222)
<223> RXN02992
<400> 649
atc gtc cct ttg ggc aac aca ctg atc gca ctg act aag aac acc acc 48
Ile Val Pro Leu Gly Asn Thr Leu Ile Ala Leu Thr Lys Asn Thr Thr
1 5 10 15
atc gcc tct gtc att gga gtt ggc gaa gcc tcc ctg ctg atg aaa gcc 96
Ile Ala Ser Val Ile Gly Val Gly Glu Ala Ser Leu Leu Met Lys Ala
20 25 30
acc atc gaa aat cac gcc aac atg cta ttt gtc gtg ttc gcg atc ttc 144
Thr Ile Glu Asn His Ala Asn Met Leu Phe Val Val Phe Ala Ile Phe
35 40 45
gcc gtt ggc ttc atg att ctg acc ctg cct atg ggc ctt ggc ttg ggc 192
Ala Val Gly Phe Met Ile Leu Thr Leu Pro Met Gly Leu Gly Leu Gly
50 55 60
aaa ctc tct gag cgt ttg gcg gtg aag aag taatggctaa tacagttcgc 242
Lys Leu Ser Glu Arg Leu Ala Val Lys Lys
65 70
gca 245
<210> 650
<211> 74
<212> PRT
<213> Corynebacterium glutamicum
<400> 650
Ile Val Pro Leu Gly Asn Thr Leu Ile Ala Leu Thr Lys Asn Thr Thr
1 5 10 15
Ile Ala Ser Val Ile Gly Val Gly Glu Ala Ser Leu Leu Met Lys Ala
20 25 30
Thr Ile Glu Asn His Ala Asn Met Leu Phe Val Val Phe Ala Ile Phe
35 40 45
Ala Val Gly Phe Met Ile Leu Thr Leu Pro Met Gly Leu Gly Leu Gly
50 55 60
Lys Leu Ser Glu Arg Leu Ala Val Lys Lys
65 70
<210> 651
<211> 792
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(769)
<223> RXN02996
<400> 651
tcctgccaca gaatctgcct gctgctccat taactaaaaa ttgcaggcta gaatagaggg 60
tcgattagga gtcgatgaaa aagtcggcgc caacgaggag atg aac aac aac gtg 115
Met Asn Asn Asn Val
1 5
agt gat caa aag cta agt ggt aaa gag ctt gcg gca cta gag aaa caa 163
Ser Asp Gln Lys Leu Ser Gly Lys Glu Leu Ala Ala Leu Glu Lys Gln
10 15 20
gcc gca aaa act ctc gaa ctt ggt gat aag aag tgg tat ctc atc gcg 211
Ala Ala Lys Thr Leu Glu Leu Gly Asp Lys Lys Trp Tyr Leu Ile Ala
25 30 35
gga gtc gtg ctt ttc gcc atc gca ctc gtc ctc cca cat atc cgt gga 259
Gly Val Val Leu Phe Ala Ile Ala Leu Val Leu Pro His Ile Arg Gly
40 45 50
gtg atg ggc tgg cag gtt ctg acg ctg tcg aat gtc gcg gag gat gcc 307
Val Met Gly Trp Gln Val Leu Thr Leu Ser Asn Val Ala Glu Asp Ala
55 60 65
ggc att acc ctt ggt gag tac ggt ttc tac tgg ttg ggc acc atc ggt 355
Gly Ile Thr Leu Gly Glu Tyr Gly Phe Tyr Trp Leu Gly Thr Ile Gly
70 75 80 85
gta ttc ctg ctt tct ttg ggc act gtc gtg ttt aag cgc acg tgg atg 403
Val Phe Leu Leu Ser Leu Gly Thr Val Val Phe Lys Arg Thr Trp Met
90 95 100
gcg tgg att tca tgg att ttc tcc tgc gtc act ctt gtg ttc gct gtg 451
Ala Trp Ile Ser Trp Ile Phe Ser Cys Val Thr Leu Val Phe Ala Val
105 110 115
ttt gcc atc tgg atg cgc caa aca acc acc agc acc caa gtg aat ttc 499
Phe Ala Ile Trp Met Arg Gln Thr Thr Thr Ser Thr Gln Val Asn Phe
120 125 130
gtc aac att ggc atg atg ctt gct gtg att gca gcg atc ctt gct gtg 547
Val Asn Ile Gly Met Met Leu Ala Val Ile Ala Ala Ile Leu Ala Val
135 140 145
tgg ggt cta tct tcg gtg att ttg gcc cgc agt gat cgc caa atg gag 595
Trp Gly Leu Ser Ser Val Ile Leu Ala Arg Ser Asp Arg Gln Met Glu
150 155 160 165
atc gct gaa atg cgc gcc gag aac cca gac ctt gat ggt gtt gca gct 643
Ile Ala Glu Met Arg Ala Glu Asn Pro Asp Leu Asp Gly Val Ala Ala
170 175 180
acc cag cgc gca ctt ctt gag cag cag caa agc aac cca gaa gat aat 691
Thr Gln Arg Ala Leu Leu Glu Gln Gln Gln Ser Asn Pro Glu Asp Asn
185 190 195
cct ttg ctt gtc gac gat cgt cgc gcc cgc atc gcc cgc cgc cgc gag 739
Pro Leu Leu Val Asp Asp Arg Arg Ala Arg Ile Ala Arg Arg Arg Glu
200 205 210
cgt gaa cag gat gca caa ggg gag cag gct taagttctag ttcaagcggt 789
Arg Glu Gln Asp Ala Gln Gly Glu Gln Ala
215 220
tga 792
<210> 652
<211> 223
<212> PRT
<213> Corynebacterium glutamicum
<400> 652
Met Asn Asn Asn Val Ser Asp Gln Lys Leu Ser Gly Lys Glu Leu Ala
1 5 10 15
Ala Leu Glu Lys Gln Ala Ala Lys Thr Leu Glu Leu Gly Asp Lys Lys
20 25 30
Trp Tyr Leu Ile Ala Gly Val Val Leu Phe Ala Ile Ala Leu Val Leu
35 40 45
Pro His Ile Arg Gly Val Met Gly Trp Gln Val Leu Thr Leu Ser Asn
50 55 60
Val Ala Glu Asp Ala Gly Ile Thr Leu Gly Glu Tyr Gly Phe Tyr Trp
65 70 75 80
Leu Gly Thr Ile Gly Val Phe Leu Leu Ser Leu Gly Thr Val Val Phe
85 90 95
Lys Arg Thr Trp Met Ala Trp Ile Ser Trp Ile Phe Ser Cys Val Thr
100 105 110
Leu Val Phe Ala Val Phe Ala Ile Trp Met Arg Gln Thr Thr Thr Ser
115 120 125
Thr Gln Val Asn Phe Val Asn Ile Gly Met Met Leu Ala Val Ile Ala
130 135 140
Ala Ile Leu Ala Val Trp Gly Leu Ser Ser Val Ile Leu Ala Arg Ser
145 150 155 160
Asp Arg Gln Met Glu Ile Ala Glu Met Arg Ala Glu Asn Pro Asp Leu
165 170 175
Asp Gly Val Ala Ala Thr Gln Arg Ala Leu Leu Glu Gln Gln Gln Ser
180 185 190
Asn Pro Glu Asp Asn Pro Leu Leu Val Asp Asp Arg Arg Ala Arg Ile
195 200 205
Ala Arg Arg Arg Glu Arg Glu Gln Asp Ala Gln Gly Glu Gln Ala
210 215 220
<210> 653
<211> 1017
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(994)
<223> RXN03126
<400> 653
tcttggacaa cattacccca cacacgggac actcaaacgt gcatgaattc acctgtcgtc 60
gatacccaaa aatcactcca ccaccactag ggtgtcttat gtg cag gaa caa tcg 115
Val Gln Glu Gln Ser
1 5
aag cag aaa gac ctc cag gct gat atc gcc aga atc act gcc gtg aaa 163
Lys Gln Lys Asp Leu Gln Ala Asp Ile Ala Arg Ile Thr Ala Val Lys
10 15 20
tcg gac aca gtt ccg aat tcc cag tca atg acc ttt ggc gct gcc tgg 211
Ser Asp Thr Val Pro Asn Ser Gln Ser Met Thr Phe Gly Ala Ala Trp
25 30 35
aac gat atc gtc cgc gga ttc aag caa cat gag ttg tgg ctg caa ctc 259
Asn Asp Ile Val Arg Gly Phe Lys Gln His Glu Leu Trp Leu Gln Leu
40 45 50
ggc tgg caa gac att aag caa cgc tac cgg cga tcc gtc ctt ggg ccc 307
Gly Trp Gln Asp Ile Lys Gln Arg Tyr Arg Arg Ser Val Leu Gly Pro
55 60 65
ctg tgg atc acc atc gcc acc ggt gtc atg gcg ctc gcc ctc ggc ttg 355
Leu Trp Ile Thr Ile Ala Thr Gly Val Met Ala Leu Ala Leu Gly Leu
70 75 80 85
ctg tac tcc gtg ctg ttc aaa atc ccc atc gcg gaa ttt ctg ccc cac 403
Leu Tyr Ser Val Leu Phe Lys Ile Pro Ile Ala Glu Phe Leu Pro His
90 95 100
gtc acc gtc ggc ctg atc att tgg aac ttc atc tcc gga tgc atc aaa 451
Val Thr Val Gly Leu Ile Ile Trp Asn Phe Ile Ser Gly Cys Ile Lys
105 110 115
gaa ggc tcc gac atc ttc ata gat aac gag gga ctc atc aaa cag ctc 499
Glu Gly Ser Asp Ile Phe Ile Asp Asn Glu Gly Leu Ile Lys Gln Leu
120 125 130
ccc tcg gcg ctg tcc gtc cac gtg tac aga ctc gtg tgg aaa caa gcc 547
Pro Ser Ala Leu Ser Val His Val Tyr Arg Leu Val Trp Lys Gln Ala
135 140 145
ctc ttc ctc gcc cac aac ctg gtc atc tgg gtc att ctc atg atg atc 595
Leu Phe Leu Ala His Asn Leu Val Ile Trp Val Ile Leu Met Met Ile
150 155 160 165
ttc ccc cga ccc ctc ggc tgg gac gtc ctc ctg atc atc ccc gca atg 643
Phe Pro Arg Pro Leu Gly Trp Asp Val Leu Leu Ile Ile Pro Ala Met
170 175 180
ttc ctc ctg gtg atc aac ggc gtg tgg gta gtc atg ttc ttc ggc atc 691
Phe Leu Leu Val Ile Asn Gly Val Trp Val Val Met Phe Phe Gly Ile
185 190 195
atc gcc acc cgc tac cgc gac gtc tcc ccg ttg cta gaa gcc gga acc 739
Ile Ala Thr Arg Tyr Arg Asp Val Ser Pro Leu Leu Glu Ala Gly Thr
200 205 210
caa ctc ctc ttc tac gtc acc ccc atc gtc tgg atg act tcc acc ctg 787
Gln Leu Leu Phe Tyr Val Thr Pro Ile Val Trp Met Thr Ser Thr Leu
215 220 225
caa tcc cag agc gca gaa atc ggc aac cgc gca cgc ctc gcc gaa ctc 835
Gln Ser Gln Ser Ala Glu Ile Gly Asn Arg Ala Arg Leu Ala Glu Leu
230 235 240 245
aac ccg ctc tac cac tac ctc gaa att gtc cgc gcc ccc atg gtc ggc 883
Asn Pro Leu Tyr His Tyr Leu Glu Ile Val Arg Ala Pro Met Val Gly
250 255 260
gcc gac ctc ccc gcc tac cac tgg tgg atc gtc ctc gcc ttc aca ttc 931
Ala Asp Leu Pro Ala Tyr His Trp Trp Ile Val Leu Ala Phe Thr Phe
265 270 275
gtc ggc ctt ggc ctt gct ctc ctc gcg atg aag caa tgg cga ttc cgc 979
Val Gly Leu Gly Leu Ala Leu Leu Ala Met Lys Gln Trp Arg Phe Arg
280 285 290
gtc agc tac tgg gta taaggagcac cacatggtat cca 1017
Val Ser Tyr Trp Val
295
<210> 654
<211> 298
<212> PRT
<213> Corynebacterium glutamicum
<400> 654
Val Gln Glu Gln Ser Lys Gln Lys Asp Leu Gln Ala Asp Ile Ala Arg
1 5 10 15
Ile Thr Ala Val Lys Ser Asp Thr Val Pro Asn Ser Gln Ser Met Thr
20 25 30
Phe Gly Ala Ala Trp Asn Asp Ile Val Arg Gly Phe Lys Gln His Glu
35 40 45
Leu Trp Leu Gln Leu Gly Trp Gln Asp Ile Lys Gln Arg Tyr Arg Arg
50 55 60
Ser Val Leu Gly Pro Leu Trp Ile Thr Ile Ala Thr Gly Val Met Ala
65 70 75 80
Leu Ala Leu Gly Leu Leu Tyr Ser Val Leu Phe Lys Ile Pro Ile Ala
85 90 95
Glu Phe Leu Pro His Val Thr Val Gly Leu Ile Ile Trp Asn Phe Ile
100 105 110
Ser Gly Cys Ile Lys Glu Gly Ser Asp Ile Phe Ile Asp Asn Glu Gly
115 120 125
Leu Ile Lys Gln Leu Pro Ser Ala Leu Ser Val His Val Tyr Arg Leu
130 135 140
Val Trp Lys Gln Ala Leu Phe Leu Ala His Asn Leu Val Ile Trp Val
145 150 155 160
Ile Leu Met Met Ile Phe Pro Arg Pro Leu Gly Trp Asp Val Leu Leu
165 170 175
Ile Ile Pro Ala Met Phe Leu Leu Val Ile Asn Gly Val Trp Val Val
180 185 190
Met Phe Phe Gly Ile Ile Ala Thr Arg Tyr Arg Asp Val Ser Pro Leu
195 200 205
Leu Glu Ala Gly Thr Gln Leu Leu Phe Tyr Val Thr Pro Ile Val Trp
210 215 220
Met Thr Ser Thr Leu Gln Ser Gln Ser Ala Glu Ile Gly Asn Arg Ala
225 230 235 240
Arg Leu Ala Glu Leu Asn Pro Leu Tyr His Tyr Leu Glu Ile Val Arg
245 250 255
Ala Pro Met Val Gly Ala Asp Leu Pro Ala Tyr His Trp Trp Ile Val
260 265 270
Leu Ala Phe Thr Phe Val Gly Leu Gly Leu Ala Leu Leu Ala Met Lys
275 280 285
Gln Trp Arg Phe Arg Val Ser Tyr Trp Val
290 295
<210> 655
<211> 927
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(904)
<223> RXN00443
<400> 655
taaacaagga gcgtttaatt tccacccaat cccactgaaa gtttcccacc ccacagttat 60
gctgattaag tactgaactt accgtaggaa aggcactcag gtg aac aaa agt atc 115
Val Asn Lys Ser Ile
1 5
cgt cga gct ctc tac agt ttc atc act att tcg gcg ggt atc tca ctc 163
Arg Arg Ala Leu Tyr Ser Phe Ile Thr Ile Ser Ala Gly Ile Ser Leu
10 15 20
gta gcg tgc tct tct tca gac acc gca agc act acc acc cag aat gcc 211
Val Ala Cys Ser Ser Ser Asp Thr Ala Ser Thr Thr Thr Gln Asn Ala
25 30 35
tct gct acc gaa gca gct ggg gtt tcc gga acc gct agc gtt ttc gct 259
Ser Ala Thr Glu Ala Ala Gly Val Ser Gly Thr Ala Ser Val Phe Ala
40 45 50
gcg gcg tct ttg acc aac gtt gct gag gat ctc gcg gct gcg ttc aac 307
Ala Ala Ser Leu Thr Asn Val Ala Glu Asp Leu Ala Ala Ala Phe Asn
55 60 65
gaa gac aat cct gat gca aag ttg gag ttt aac ttc gct ggt tct tcc 355
Glu Asp Asn Pro Asp Ala Lys Leu Glu Phe Asn Phe Ala Gly Ser Ser
70 75 80 85
gcg ctg gtt cgc cag atc agc gaa ggc gca cca tct gat ctg ttc att 403
Ala Leu Val Arg Gln Ile Ser Glu Gly Ala Pro Ser Asp Leu Phe Ile
90 95 100
tct gcg gac atc gcc aac atg gac gat gcg ctg gca ctt cca gaa ttt 451
Ser Ala Asp Ile Ala Asn Met Asp Asp Ala Leu Ala Leu Pro Glu Phe
105 110 115
gcc ggc gca acc tcg aag gtc atc gct acc aac aag ctg gtg ctg gtc 499
Ala Gly Ala Thr Ser Lys Val Ile Ala Thr Asn Lys Leu Val Leu Val
120 125 130
acc gca gac ggc aac ccc ggc gaa att tca gag ctt gcc gac gtc aag 547
Thr Ala Asp Gly Asn Pro Gly Glu Ile Ser Glu Leu Ala Asp Val Lys
135 140 145
gac tcc ctc gtt gct atc tgc gcc cct gaa gtt cca tgt gga acc atc 595
Asp Ser Leu Val Ala Ile Cys Ala Pro Glu Val Pro Cys Gly Thr Ile
150 155 160 165
acc cac gag gct ttg gac tac gca gac atc gag ttg aac acc agc tct 643
Thr His Glu Ala Leu Asp Tyr Ala Asp Ile Glu Leu Asn Thr Ser Ser
170 175 180
gag gaa gcc aat gtt gct gat gtc gcc acg aag att tcc acc ggt gca 691
Glu Glu Ala Asn Val Ala Asp Val Ala Thr Lys Ile Ser Thr Gly Ala
185 190 195
gtt gat gcg ggc ttt gtt tac caa acc gac gct cag tct ttg gct aaa 739
Val Asp Ala Gly Phe Val Tyr Gln Thr Asp Ala Gln Ser Leu Ala Lys
200 205 210
act cag gac aac act gtc att gaa ctc gaa ggt atc gac gcc aac gaa 787
Thr Gln Asp Asn Thr Val Ile Glu Leu Glu Gly Ile Asp Ala Asn Glu
215 220 225
tac cca atg gca ttg acc acc acc ggt gaa gac aac gag gta gcg aag 835
Tyr Pro Met Ala Leu Thr Thr Thr Gly Glu Asp Asn Glu Val Ala Lys
230 235 240 245
gct ttc gca gag ttc ctc agc agc gat cgt gcc aag gag atc ctt gcc 883
Ala Phe Ala Glu Phe Leu Ser Ser Asp Arg Ala Lys Glu Ile Leu Ala
250 255 260
agc tat ggt ttt ggc aca aac taaaaaggct cgtcgaagcg aga 927
Ser Tyr Gly Phe Gly Thr Asn
265
<210> 656
<211> 268
<212> PRT
<213> Corynebacterium glutamicum
<400> 656
Val Asn Lys Ser Ile Arg Arg Ala Leu Tyr Ser Phe Ile Thr Ile Ser
1 5 10 15
Ala Gly Ile Ser Leu Val Ala Cys Ser Ser Ser Asp Thr Ala Ser Thr
20 25 30
Thr Thr Gln Asn Ala Ser Ala Thr Glu Ala Ala Gly Val Ser Gly Thr
35 40 45
Ala Ser Val Phe Ala Ala Ala Ser Leu Thr Asn Val Ala Glu Asp Leu
50 55 60
Ala Ala Ala Phe Asn Glu Asp Asn Pro Asp Ala Lys Leu Glu Phe Asn
65 70 75 80
Phe Ala Gly Ser Ser Ala Leu Val Arg Gln Ile Ser Glu Gly Ala Pro
85 90 95
Ser Asp Leu Phe Ile Ser Ala Asp Ile Ala Asn Met Asp Asp Ala Leu
100 105 110
Ala Leu Pro Glu Phe Ala Gly Ala Thr Ser Lys Val Ile Ala Thr Asn
115 120 125
Lys Leu Val Leu Val Thr Ala Asp Gly Asn Pro Gly Glu Ile Ser Glu
130 135 140
Leu Ala Asp Val Lys Asp Ser Leu Val Ala Ile Cys Ala Pro Glu Val
145 150 155 160
Pro Cys Gly Thr Ile Thr His Glu Ala Leu Asp Tyr Ala Asp Ile Glu
165 170 175
Leu Asn Thr Ser Ser Glu Glu Ala Asn Val Ala Asp Val Ala Thr Lys
180 185 190
Ile Ser Thr Gly Ala Val Asp Ala Gly Phe Val Tyr Gln Thr Asp Ala
195 200 205
Gln Ser Leu Ala Lys Thr Gln Asp Asn Thr Val Ile Glu Leu Glu Gly
210 215 220
Ile Asp Ala Asn Glu Tyr Pro Met Ala Leu Thr Thr Thr Gly Glu Asp
225 230 235 240
Asn Glu Val Ala Lys Ala Phe Ala Glu Phe Leu Ser Ser Asp Arg Ala
245 250 255
Lys Glu Ile Leu Ala Ser Tyr Gly Phe Gly Thr Asn
260 265
<210> 657
<211> 960
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(937)
<223> RXN00444
<400> 657
tacccaatgg cattgaccac caccggtgaa gacaacgagg tagcgaaggc tttcgcagag 60
ttcctcagca gcgatcgtgc caaggagatc cttgccagct atg gtt ttg gca caa 115
Met Val Leu Ala Gln
1 5
act aaa aag gct cgt cga agc gag aat cat atc ctc cca ggg tgg ttg 163
Thr Lys Lys Ala Arg Arg Ser Glu Asn His Ile Leu Pro Gly Trp Leu
10 15 20
ctc atc cca gcc acc ctg gcc atg ctg ctg atc att gga cct att ttt 211
Leu Ile Pro Ala Thr Leu Ala Met Leu Leu Ile Ile Gly Pro Ile Phe
25 30 35
gct ttg ctg ttg cag atc ccc tgg gat cgg tct tgg gag ttg ctt acc 259
Ala Leu Leu Leu Gln Ile Pro Trp Asp Arg Ser Trp Glu Leu Leu Thr
40 45 50
gcg ccg gaa tct tta gga acc gca cgg tta tct atc gga act gct ctg 307
Ala Pro Glu Ser Leu Gly Thr Ala Arg Leu Ser Ile Gly Thr Ala Leu
55 60 65
ttt tct acc gcg cta tgc gca att gtg ggt ttc ccg cta gcg ttg gcg 355
Phe Ser Thr Ala Leu Cys Ala Ile Val Gly Phe Pro Leu Ala Leu Ala
70 75 80 85
ctg cat tta tat gag cgt tcg cac ccc agg gtg aca tca gtt ttg acg 403
Leu His Leu Tyr Glu Arg Ser His Pro Arg Val Thr Ser Val Leu Thr
90 95 100
gtg ctg gtt tat gcg cct ttg gtg ttg tcg ccg gtg gtg tct ggt ttg 451
Val Leu Val Tyr Ala Pro Leu Val Leu Ser Pro Val Val Ser Gly Leu
105 110 115
gcg ctg act ttt ctg tgg ggc agg cgt ggt ttt tta ggt tct tgg ctt 499
Ala Leu Thr Phe Leu Trp Gly Arg Arg Gly Phe Leu Gly Ser Trp Leu
120 125 130
gat cag gtt gga ttg ccg att gca ttt acc acc acg gct gtg gtg ttt 547
Asp Gln Val Gly Leu Pro Ile Ala Phe Thr Thr Thr Ala Val Val Phe
135 140 145
gcc cag gtg ttt gta gcg ttg cca ttt ttc att tcc act gtg act act 595
Ala Gln Val Phe Val Ala Leu Pro Phe Phe Ile Ser Thr Val Thr Thr
150 155 160 165
gca ctg cgt ggc att cca aaa cag ttt gag gaa atc gca gct act gaa 643
Ala Leu Arg Gly Ile Pro Lys Gln Phe Glu Glu Ile Ala Ala Thr Glu
170 175 180
ggc gca acc cgc tgg gag atc atg cac aag atg atc att ccg ctg gcg 691
Gly Ala Thr Arg Trp Glu Ile Met His Lys Met Ile Ile Pro Leu Ala
185 190 195
atg cct gga att ttc acc ggt atg att ttg gga ttc gcc agg gcc ttg 739
Met Pro Gly Ile Phe Thr Gly Met Ile Leu Gly Phe Ala Arg Ala Leu
200 205 210
ggc gag tat ggt gcg aca ctg act ttt gct gga aat att gca ggt gtt 787
Gly Glu Tyr Gly Ala Thr Leu Thr Phe Ala Gly Asn Ile Ala Gly Val
215 220 225
acc cgc acc att ccg ttg cat att gag ctt ggt ttg agt tcc aat gac 835
Thr Arg Thr Ile Pro Leu His Ile Glu Leu Gly Leu Ser Ser Asn Asp
230 235 240 245
atg gat aaa gcc ttg gga gcg gtg att atg ctt ttg gct gtc tat gtc 883
Met Asp Lys Ala Leu Gly Ala Val Ile Met Leu Leu Ala Val Tyr Val
250 255 260
ctc atc att gga gcc atc gga gcg tta cga ttg ttt tcc aag gtg aga 931
Leu Ile Ile Gly Ala Ile Gly Ala Leu Arg Leu Phe Ser Lys Val Arg
265 270 275
aag gtt taattgatgt ctcgttcgcc gga 960
Lys Val
<210> 658
<211> 279
<212> PRT
<213> Corynebacterium glutamicum
<400> 658
Met Val Leu Ala Gln Thr Lys Lys Ala Arg Arg Ser Glu Asn His Ile
1 5 10 15
Leu Pro Gly Trp Leu Leu Ile Pro Ala Thr Leu Ala Met Leu Leu Ile
20 25 30
Ile Gly Pro Ile Phe Ala Leu Leu Leu Gln Ile Pro Trp Asp Arg Ser
35 40 45
Trp Glu Leu Leu Thr Ala Pro Glu Ser Leu Gly Thr Ala Arg Leu Ser
50 55 60
Ile Gly Thr Ala Leu Phe Ser Thr Ala Leu Cys Ala Ile Val Gly Phe
65 70 75 80
Pro Leu Ala Leu Ala Leu His Leu Tyr Glu Arg Ser His Pro Arg Val
85 90 95
Thr Ser Val Leu Thr Val Leu Val Tyr Ala Pro Leu Val Leu Ser Pro
100 105 110
Val Val Ser Gly Leu Ala Leu Thr Phe Leu Trp Gly Arg Arg Gly Phe
115 120 125
Leu Gly Ser Trp Leu Asp Gln Val Gly Leu Pro Ile Ala Phe Thr Thr
130 135 140
Thr Ala Val Val Phe Ala Gln Val Phe Val Ala Leu Pro Phe Phe Ile
145 150 155 160
Ser Thr Val Thr Thr Ala Leu Arg Gly Ile Pro Lys Gln Phe Glu Glu
165 170 175
Ile Ala Ala Thr Glu Gly Ala Thr Arg Trp Glu Ile Met His Lys Met
180 185 190
Ile Ile Pro Leu Ala Met Pro Gly Ile Phe Thr Gly Met Ile Leu Gly
195 200 205
Phe Ala Arg Ala Leu Gly Glu Tyr Gly Ala Thr Leu Thr Phe Ala Gly
210 215 220
Asn Ile Ala Gly Val Thr Arg Thr Ile Pro Leu His Ile Glu Leu Gly
225 230 235 240
Leu Ser Ser Asn Asp Met Asp Lys Ala Leu Gly Ala Val Ile Met Leu
245 250 255
Leu Ala Val Tyr Val Leu Ile Ile Gly Ala Ile Gly Ala Leu Arg Leu
260 265 270
Phe Ser Lys Val Arg Lys Val
275
<210> 659
<211> 594
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (1)..(594)
<223> RXN00193
<220>
<221> misc_feature
<222> 11
<223> n indicates any nucleotide
<220>
<221> VARIANT
<222> 4
<223> Xaa = Phe, Ser, Tyr, or Cys
<400> 659
aaa gct ttc tnc caa cgc gaa ggt ttc atc tca gcc ttc ggt ttc acc 48
Lys Ala Phe Xaa Gln Arg Glu Gly Phe Ile Ser Ala Phe Gly Phe Thr
1 5 10 15
gtc ctc gtg gtc atc gtc tcc gtg atc aca gtc aac atc ttc gcc ttc 96
Val Leu Val Val Ile Val Ser Val Ile Thr Val Asn Ile Phe Ala Phe
20 25 30
ctc ttg gcg tgg ttg ctg acc cgc aaa ctc cgc ggt acc aac ttt ttc 144
Leu Leu Ala Trp Leu Leu Thr Arg Lys Leu Arg Gly Thr Asn Phe Phe
35 40 45
cgc aca gtc ttc ttt atg ccg aac ctt atc ggc ggc att gtg ctg ggt 192
Arg Thr Val Phe Phe Met Pro Asn Leu Ile Gly Gly Ile Val Leu Gly
50 55 60
tat acc tgg cag acc atg atc aac gcc gtg ctt tcg cac tat gcc acg 240
Tyr Thr Trp Gln Thr Met Ile Asn Ala Val Leu Ser His Tyr Ala Thr
65 70 75 80
act att agc gcg gac tgg aaa ttc ggc tac gcc ggc ctc atc atg cta 288
Thr Ile Ser Ala Asp Trp Lys Phe Gly Tyr Ala Gly Leu Ile Met Leu
85 90 95
ctt aac tgg cag ctc atc ggc tac atg atg atc att tac atc gcc ggc 336
Leu Asn Trp Gln Leu Ile Gly Tyr Met Met Ile Ile Tyr Ile Ala Gly
100 105 110
ctg caa aac gtc cca cca gag ctc att gag gct gcc gaa ctc gac ggc 384
Leu Gln Asn Val Pro Pro Glu Leu Ile Glu Ala Ala Glu Leu Asp Gly
115 120 125
gtc aac aag tgg gag atg ctg cgg cac gtc act att ccg atg gtc atg 432
Val Asn Lys Trp Glu Met Leu Arg His Val Thr Ile Pro Met Val Met
130 135 140
cca tcc atc acc atc tgc ctc ttt ttg act ttg tcg aac tcc ttt aag 480
Pro Ser Ile Thr Ile Cys Leu Phe Leu Thr Leu Ser Asn Ser Phe Lys
145 150 155 160
ctc ttc gac cag aac ctg gcg ctg acc aac ggc gct cct ggc ggg caa 528
Leu Phe Asp Gln Asn Leu Ala Leu Thr Asn Gly Ala Pro Gly Gly Gln
165 170 175
act gag atg gtg gcg ctc aac atc atc aac acg ctg ttt aac cgt atg 576
Thr Glu Met Val Ala Leu Asn Ile Ile Asn Thr Leu Phe Asn Arg Met
180 185 190
aat gtc gag ggc gtc ggt 594
Asn Val Glu Gly Val Gly
195
<210> 660
<211> 198
<212> PRT
<213> Corynebacterium glutamicum
<220>
<221> VARIANT
<222> 4
<223> Xaa = Phe, Ser, Tyr, or Cys
<400> 660
Lys Ala Phe Xaa Gln Arg Glu Gly Phe Ile Ser Ala Phe Gly Phe Thr
1 5 10 15
Val Leu Val Val Ile Val Ser Val Ile Thr Val Asn Ile Phe Ala Phe
20 25 30
Leu Leu Ala Trp Leu Leu Thr Arg Lys Leu Arg Gly Thr Asn Phe Phe
35 40 45
Arg Thr Val Phe Phe Met Pro Asn Leu Ile Gly Gly Ile Val Leu Gly
50 55 60
Tyr Thr Trp Gln Thr Met Ile Asn Ala Val Leu Ser His Tyr Ala Thr
65 70 75 80
Thr Ile Ser Ala Asp Trp Lys Phe Gly Tyr Ala Gly Leu Ile Met Leu
85 90 95
Leu Asn Trp Gln Leu Ile Gly Tyr Met Met Ile Ile Tyr Ile Ala Gly
100 105 110
Leu Gln Asn Val Pro Pro Glu Leu Ile Glu Ala Ala Glu Leu Asp Gly
115 120 125
Val Asn Lys Trp Glu Met Leu Arg His Val Thr Ile Pro Met Val Met
130 135 140
Pro Ser Ile Thr Ile Cys Leu Phe Leu Thr Leu Ser Asn Ser Phe Lys
145 150 155 160
Leu Phe Asp Gln Asn Leu Ala Leu Thr Asn Gly Ala Pro Gly Gly Gln
165 170 175
Thr Glu Met Val Ala Leu Asn Ile Ile Asn Thr Leu Phe Asn Arg Met
180 185 190
Asn Val Glu Gly Val Gly
195
<210> 661
<211> 1053
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1030)
<223> RXN01298
<400> 661
cttaaacgtc accttattta tgcattatgt tggtttcaga ctcgaacaat tcaattagaa 60
aacactaatc ggacatttag gtcacataac atttccgctc gtg tcc aca tta att 115
Val Ser Thr Leu Ile
1 5
tct gaa ccc gag gtg gat aag cta cgt aaa cgt gcc aag aga tca agg 163
Ser Glu Pro Glu Val Asp Lys Leu Arg Lys Arg Ala Lys Arg Ser Arg
10 15 20
cgg aca gaa tgg tgg ctt gcc gcc gca ctt ctt gcc cca aac ttg ctt 211
Arg Thr Glu Trp Trp Leu Ala Ala Ala Leu Leu Ala Pro Asn Leu Leu
25 30 35
ctc ttg gcc atc ttt acg tat cgg cca ctg tta gat aac ttc cgg ttg 259
Leu Leu Ala Ile Phe Thr Tyr Arg Pro Leu Leu Asp Asn Phe Arg Leu
40 45 50
tcc ttt ttc aac tgg aac att tcc tcg ccc aca tca acc ttc att ggg 307
Ser Phe Phe Asn Trp Asn Ile Ser Ser Pro Thr Ser Thr Phe Ile Gly
55 60 65
ttt gat aac tac gtt gag ttc ttc act cgt agt gac act ctc caa gtt 355
Phe Asp Asn Tyr Val Glu Phe Phe Thr Arg Ser Asp Thr Leu Gln Val
70 75 80 85
gtt tta aac acc gtc atc ttc acg gca tgt gct gtg atc gga tcg atg 403
Val Leu Asn Thr Val Ile Phe Thr Ala Cys Ala Val Ile Gly Ser Met
90 95 100
gtg ctc ggt ttg ctc ctg gcc atg ttg ttg gat cag aag ctt ttc ggc 451
Val Leu Gly Leu Leu Leu Ala Met Leu Leu Asp Gln Lys Leu Phe Gly
105 110 115
cgt aac ttt gtg cgt tcc atg gtg ttt gcc ccg ttt gtg att tcc ggt 499
Arg Asn Phe Val Arg Ser Met Val Phe Ala Pro Phe Val Ile Ser Gly
120 125 130
gct gcc att ggt gtt gct ttc cag ttc gtt ttt gac cct aat ttt ggt 547
Ala Ala Ile Gly Val Ala Phe Gln Phe Val Phe Asp Pro Asn Phe Gly
135 140 145
ttg gtt cag gac ttg ctg gga cgc atc ggc gtt gat tcg cca cag ttc 595
Leu Val Gln Asp Leu Leu Gly Arg Ile Gly Val Asp Ser Pro Gln Phe
150 155 160 165
tac caa aac cct aac tgg gca ttg ttc atg gtg acg ttc act ttc gtg 643
Tyr Gln Asn Pro Asn Trp Ala Leu Phe Met Val Thr Phe Thr Phe Val
170 175 180
tgg aag aac ttg ggc tac tcc ttt gtt atc tac ctg gct gca ttg cag 691
Trp Lys Asn Leu Gly Tyr Ser Phe Val Ile Tyr Leu Ala Ala Leu Gln
185 190 195
ggg cta aac aag gat ttg tct gag gcc gca ccg gtg gat ggc gcg agc 739
Gly Leu Asn Lys Asp Leu Ser Glu Ala Ala Pro Val Asp Gly Ala Ser
200 205 210
gcg tgg aca cgt ttt tgg aag gtt act ctt ccg cag ctt cgc cca acc 787
Ala Trp Thr Arg Phe Trp Lys Val Thr Leu Pro Gln Leu Arg Pro Thr
215 220 225
acg ttc ttc ctt tct att act gtc acg ctg aac tcg gtt cag gtc ttc 835
Thr Phe Phe Leu Ser Ile Thr Val Thr Leu Asn Ser Val Gln Val Phe
230 235 240 245
gac atc att cac acc atg act cgt ggt ggc ccc ttg ggt aac ggt acg 883
Asp Ile Ile His Thr Met Thr Arg Gly Gly Pro Leu Gly Asn Gly Thr
250 255 260
acc acc ttg gtt tac cag gtg tac acc gag act ttc acc aac tat cgc 931
Thr Thr Leu Val Tyr Gln Val Tyr Thr Glu Thr Phe Thr Asn Tyr Arg
265 270 275
gcg gga tat ggt gca aca atc gca acg att ttg ttc ctg ttg ctg ctg 979
Ala Gly Tyr Gly Ala Thr Ile Ala Thr Ile Leu Phe Leu Leu Leu Leu
280 285 290
att atc act gtt atc cag gtt cga tac atg gat aag gag aac aag cag 1027
Ile Ile Thr Val Ile Gln Val Arg Tyr Met Asp Lys Glu Asn Lys Gln
295 300 305
aaa tgatctcgac tgatagaaac gtt 1053
Lys
310
<210> 662
<211> 310
<212> PRT
<213> Corynebacterium glutamicum
<400> 662
Val Ser Thr Leu Ile Ser Glu Pro Glu Val Asp Lys Leu Arg Lys Arg
1 5 10 15
Ala Lys Arg Ser Arg Arg Thr Glu Trp Trp Leu Ala Ala Ala Leu Leu
20 25 30
Ala Pro Asn Leu Leu Leu Leu Ala Ile Phe Thr Tyr Arg Pro Leu Leu
35 40 45
Asp Asn Phe Arg Leu Ser Phe Phe Asn Trp Asn Ile Ser Ser Pro Thr
50 55 60
Ser Thr Phe Ile Gly Phe Asp Asn Tyr Val Glu Phe Phe Thr Arg Ser
65 70 75 80
Asp Thr Leu Gln Val Val Leu Asn Thr Val Ile Phe Thr Ala Cys Ala
85 90 95
Val Ile Gly Ser Met Val Leu Gly Leu Leu Leu Ala Met Leu Leu Asp
100 105 110
Gln Lys Leu Phe Gly Arg Asn Phe Val Arg Ser Met Val Phe Ala Pro
115 120 125
Phe Val Ile Ser Gly Ala Ala Ile Gly Val Ala Phe Gln Phe Val Phe
130 135 140
Asp Pro Asn Phe Gly Leu Val Gln Asp Leu Leu Gly Arg Ile Gly Val
145 150 155 160
Asp Ser Pro Gln Phe Tyr Gln Asn Pro Asn Trp Ala Leu Phe Met Val
165 170 175
Thr Phe Thr Phe Val Trp Lys Asn Leu Gly Tyr Ser Phe Val Ile Tyr
180 185 190
Leu Ala Ala Leu Gln Gly Leu Asn Lys Asp Leu Ser Glu Ala Ala Pro
195 200 205
Val Asp Gly Ala Ser Ala Trp Thr Arg Phe Trp Lys Val Thr Leu Pro
210 215 220
Gln Leu Arg Pro Thr Thr Phe Phe Leu Ser Ile Thr Val Thr Leu Asn
225 230 235 240
Ser Val Gln Val Phe Asp Ile Ile His Thr Met Thr Arg Gly Gly Pro
245 250 255
Leu Gly Asn Gly Thr Thr Thr Leu Val Tyr Gln Val Tyr Thr Glu Thr
260 265 270
Phe Thr Asn Tyr Arg Ala Gly Tyr Gly Ala Thr Ile Ala Thr Ile Leu
275 280 285
Phe Leu Leu Leu Leu Ile Ile Thr Val Ile Gln Val Arg Tyr Met Asp
290 295 300
Lys Glu Asn Lys Gln Lys
305 310
<210> 663
<211> 1182
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1159)
<223> RXA01737
<400> 663
ctttgagccg aacgatctgc cgactcaaga agaactagcc cggctgctca gtcaggaatg 60
atgcgcctaa gatcaaacaa gaatgaaagg acggtgaaca atg ggc cga atg aaa 115
Met Gly Arg Met Lys
1 5
aac gat ggt gaa ctc gcg gat ctg ccg gat cat gca ctt ttg agc att 163
Asn Asp Gly Glu Leu Ala Asp Leu Pro Asp His Ala Leu Leu Ser Ile
10 15 20
att cga atc ccg cag gcg gcg aaa aga agc ccc tgg gcg ctg atc tta 211
Ile Arg Ile Pro Gln Ala Ala Lys Arg Ser Pro Trp Ala Leu Ile Leu
25 30 35
acg cgc atc gga tac gcg atg gtg ctg ctg gtt atc gtc acc atg gtt 259
Thr Arg Ile Gly Tyr Ala Met Val Leu Leu Val Ile Val Thr Met Val
40 45 50
gtc tat ttt gac cgc aac gga tac tcc gaa gac ctc acg ttc atc gac 307
Val Tyr Phe Asp Arg Asn Gly Tyr Ser Glu Asp Leu Thr Phe Ile Asp
55 60 65
gcg ttg tac tat tcc aca gtc tcg ttg acc acc gtg ggc tac ggc gat 355
Ala Leu Tyr Tyr Ser Thr Val Ser Leu Thr Thr Val Gly Tyr Gly Asp
70 75 80 85
atc acc ccg gtg acg caa tcg gca cgc ctg atc aac atc atc gtc ctc 403
Ile Thr Pro Val Thr Gln Ser Ala Arg Leu Ile Asn Ile Ile Val Leu
90 95 100
acc cca gca cgc atc ggc ttc ctg atc ctc ctg gtc ggc acc acc ttg 451
Thr Pro Ala Arg Ile Gly Phe Leu Ile Leu Leu Val Gly Thr Thr Leu
105 110 115
tca gtg ctc acc gaa gaa tcg cgc cgg gcc ctg caa atc caa cgt tgg 499
Ser Val Leu Thr Glu Glu Ser Arg Arg Ala Leu Gln Ile Gln Arg Trp
120 125 130
aga aaa cgc atg cgc aac cac acc gtc gtt gtc gga tac gga acc aaa 547
Arg Lys Arg Met Arg Asn His Thr Val Val Val Gly Tyr Gly Thr Lys
135 140 145
ggt cgc tcc gcg gtc gct gca ctg ctt ggc gac ggc gtc ccc gcc aac 595
Gly Arg Ser Ala Val Ala Ala Leu Leu Gly Asp Gly Val Pro Ala Asn
150 155 160 165
cag atc gtt gtt atc gac acc gat caa gtc tcc ctc gac gcc gcc aac 643
Gln Ile Val Val Ile Asp Thr Asp Gln Val Ser Leu Asp Ala Ala Asn
170 175 180
aac agc gga ctc gtc acc gtc aaa ggc tcc gcc acc aaa gca gat gtg 691
Asn Ser Gly Leu Val Thr Val Lys Gly Ser Ala Thr Lys Ala Asp Val
185 190 195
ttg cgt cta gct ggc gtg tca cga gcg cgc gcc gtc gtc gtg gca ccg 739
Leu Arg Leu Ala Gly Val Ser Arg Ala Arg Ala Val Val Val Ala Pro
200 205 210
aac ctg gac gat act gca gtt ctg gtg act cta tcg gtg cga gaa atc 787
Asn Leu Asp Asp Thr Ala Val Leu Val Thr Leu Ser Val Arg Glu Ile
215 220 225
gcg ccg cag gca atg att gtg gcc agt gtc cga gaa tct gaa aac caa 835
Ala Pro Gln Ala Met Ile Val Ala Ser Val Arg Glu Ser Glu Asn Gln
230 235 240 245
cac ctc ctc gaa caa tcc ggt gcg gac tcg gtt gtg atc tcc tca gaa 883
His Leu Leu Glu Gln Ser Gly Ala Asp Ser Val Val Ile Ser Ser Glu
250 255 260
acc gct ggc cga atg ctc ggt ctg gca aca gtt acc cca tcg gtt gtg 931
Thr Ala Gly Arg Met Leu Gly Leu Ala Thr Val Thr Pro Ser Val Val
265 270 275
gag atg atg gaa gac ctc ctc tca ccc gac gaa gga ttc tcc gtt gcc 979
Glu Met Met Glu Asp Leu Leu Ser Pro Asp Glu Gly Phe Ser Val Ala
280 285 290
gaa cga cta gtc ggt gag gat gaa atc ggc tcc aac cca cga cac ctc 1027
Glu Arg Leu Val Gly Glu Asp Glu Ile Gly Ser Asn Pro Arg His Leu
295 300 305
gct gac atc gtc ctc ggt gtt gtt cga tcc ggt gag ctc tac cgc atc 1075
Ala Asp Ile Val Leu Gly Val Val Arg Ser Gly Glu Leu Tyr Arg Ile
310 315 320 325
gac tcc cca gaa gca gaa act gta gag ccc ggc gat cgt ctc ctt tac 1123
Asp Ser Pro Glu Ala Glu Thr Val Glu Pro Gly Asp Arg Leu Leu Tyr
330 335 340
gtt cgc cga gta ttt agc gag gag gta aat gac aaa tgagaattct 1169
Val Arg Arg Val Phe Ser Glu Glu Val Asn Asp Lys
345 350
tcccatcggc ccc 1182
<210> 664
<211> 353
<212> PRT
<213> Corynebacterium glutamicum
<400> 664
Met Gly Arg Met Lys Asn Asp Gly Glu Leu Ala Asp Leu Pro Asp His
1 5 10 15
Ala Leu Leu Ser Ile Ile Arg Ile Pro Gln Ala Ala Lys Arg Ser Pro
20 25 30
Trp Ala Leu Ile Leu Thr Arg Ile Gly Tyr Ala Met Val Leu Leu Val
35 40 45
Ile Val Thr Met Val Val Tyr Phe Asp Arg Asn Gly Tyr Ser Glu Asp
50 55 60
Leu Thr Phe Ile Asp Ala Leu Tyr Tyr Ser Thr Val Ser Leu Thr Thr
65 70 75 80
Val Gly Tyr Gly Asp Ile Thr Pro Val Thr Gln Ser Ala Arg Leu Ile
85 90 95
Asn Ile Ile Val Leu Thr Pro Ala Arg Ile Gly Phe Leu Ile Leu Leu
100 105 110
Val Gly Thr Thr Leu Ser Val Leu Thr Glu Glu Ser Arg Arg Ala Leu
115 120 125
Gln Ile Gln Arg Trp Arg Lys Arg Met Arg Asn His Thr Val Val Val
130 135 140
Gly Tyr Gly Thr Lys Gly Arg Ser Ala Val Ala Ala Leu Leu Gly Asp
145 150 155 160
Gly Val Pro Ala Asn Gln Ile Val Val Ile Asp Thr Asp Gln Val Ser
165 170 175
Leu Asp Ala Ala Asn Asn Ser Gly Leu Val Thr Val Lys Gly Ser Ala
180 185 190
Thr Lys Ala Asp Val Leu Arg Leu Ala Gly Val Ser Arg Ala Arg Ala
195 200 205
Val Val Val Ala Pro Asn Leu Asp Asp Thr Ala Val Leu Val Thr Leu
210 215 220
Ser Val Arg Glu Ile Ala Pro Gln Ala Met Ile Val Ala Ser Val Arg
225 230 235 240
Glu Ser Glu Asn Gln His Leu Leu Glu Gln Ser Gly Ala Asp Ser Val
245 250 255
Val Ile Ser Ser Glu Thr Ala Gly Arg Met Leu Gly Leu Ala Thr Val
260 265 270
Thr Pro Ser Val Val Glu Met Met Glu Asp Leu Leu Ser Pro Asp Glu
275 280 285
Gly Phe Ser Val Ala Glu Arg Leu Val Gly Glu Asp Glu Ile Gly Ser
290 295 300
Asn Pro Arg His Leu Ala Asp Ile Val Leu Gly Val Val Arg Ser Gly
305 310 315 320
Glu Leu Tyr Arg Ile Asp Ser Pro Glu Ala Glu Thr Val Glu Pro Gly
325 330 335
Asp Arg Leu Leu Tyr Val Arg Arg Val Phe Ser Glu Glu Val Asn Asp
340 345 350
Lys
<210> 665
<211> 2007
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1984)
<223> RXN02348
<400> 665
aaagacccga gccgaagccc tggcctgcgc atacttcctt gtcaacgctc gctgggatta 60
ggtcttttct gagcgctagc atttctccac tcaaaggagc atg ctt aac cgc atg 115
Met Leu Asn Arg Met
1 5
aaa agt gcg cgg cca aaa tca gtc gct cca aaa tcc gga caa gct tta 163
Lys Ser Ala Arg Pro Lys Ser Val Ala Pro Lys Ser Gly Gln Ala Leu
10 15 20
ctc act ctc ggt gcc cta ggt gtt gtg ttc ggc gac atc ggc acc agc 211
Leu Thr Leu Gly Ala Leu Gly Val Val Phe Gly Asp Ile Gly Thr Ser
25 30 35
ccc ctg tac tca ctt cac act gca ttc agc atg cag cac aac aaa gtc 259
Pro Leu Tyr Ser Leu His Thr Ala Phe Ser Met Gln His Asn Lys Val
40 45 50
gaa gtc act cag gaa aat gtg tac ggc atc atc tcc atg gtg ttg tgg 307
Glu Val Thr Gln Glu Asn Val Tyr Gly Ile Ile Ser Met Val Leu Trp
55 60 65
acc atc act ttg atc gtc acc gtc aaa tac gtc atg ctg gtc acc cga 355
Thr Ile Thr Leu Ile Val Thr Val Lys Tyr Val Met Leu Val Thr Arg
70 75 80 85
gct gac aac caa gga caa ggt ggc atc ctg gcg ctc gtt gct ttg ctg 403
Ala Asp Asn Gln Gly Gln Gly Gly Ile Leu Ala Leu Val Ala Leu Leu
90 95 100
aaa aac cgt ggg cac tgg gga aaa ttc gtg gca gta gcc ggc atg ttg 451
Lys Asn Arg Gly His Trp Gly Lys Phe Val Ala Val Ala Gly Met Leu
105 110 115
ggc gcc gca ttg ttt tat ggc gat gtg gtg atc acc ccg gcg atc tct 499
Gly Ala Ala Leu Phe Tyr Gly Asp Val Val Ile Thr Pro Ala Ile Ser
120 125 130
gtt ctc agc gca aca gaa ggc ttg acg gtt atc tcc cca agc ttt gag 547
Val Leu Ser Ala Thr Glu Gly Leu Thr Val Ile Ser Pro Ser Phe Glu
135 140 145
cgc ttc att ctg ccc gta tct ctc gca gtt ctg atc gct att ttt gca 595
Arg Phe Ile Leu Pro Val Ser Leu Ala Val Leu Ile Ala Ile Phe Ala
150 155 160 165
atc caa ccg ctc ggt aca gaa aaa gtc ggc aaa gcc ttc ggc ccc atc 643
Ile Gln Pro Leu Gly Thr Glu Lys Val Gly Lys Ala Phe Gly Pro Ile
170 175 180
atg ttg ctg tgg ttt gtc acc ctt gca gga ttg gga att ccg caa atc 691
Met Leu Leu Trp Phe Val Thr Leu Ala Gly Leu Gly Ile Pro Gln Ile
185 190 195
atc ggg cac cca gaa atc ttg cag agc ttg tct cca cat tgg gcc ctg 739
Ile Gly His Pro Glu Ile Leu Gln Ser Leu Ser Pro His Trp Ala Leu
200 205 210
cgc ttg att gtg gct gag cct ttc caa gca ttt gtg ctg ctt ggt gcc 787
Arg Leu Ile Val Ala Glu Pro Phe Gln Ala Phe Val Leu Leu Gly Ala
215 220 225
gtt gtc ctg aca gta acg ggt gcg gaa gcg ctc tac gct gat atg ggc 835
Val Val Leu Thr Val Thr Gly Ala Glu Ala Leu Tyr Ala Asp Met Gly
230 235 240 245
cat ttt ggg gcg agg cca atc aga gtg gcg tgg ttt tgc gtc gtc atg 883
His Phe Gly Ala Arg Pro Ile Arg Val Ala Trp Phe Cys Val Val Met
250 255 260
cct gct tta atc ttg acg tat ttg ggg cag ggc gcc ttg gtg atc aac 931
Pro Ala Leu Ile Leu Thr Tyr Leu Gly Gln Gly Ala Leu Val Ile Asn
265 270 275
cag cct gaa gcg gtg cgc aac ccc atg ttt tat ctc gcg ccg gaa ggt 979
Gln Pro Glu Ala Val Arg Asn Pro Met Phe Tyr Leu Ala Pro Glu Gly
280 285 290
ctg cgg att ccg ttg gtt att ttg gcg acc atc gct acg gtg atc gca 1027
Leu Arg Ile Pro Leu Val Ile Leu Ala Thr Ile Ala Thr Val Ile Ala
295 300 305
tcg cag gcc gtg att tct ggt gcg tat tca ttg acc aag cag gcc gtg 1075
Ser Gln Ala Val Ile Ser Gly Ala Tyr Ser Leu Thr Lys Gln Ala Val
310 315 320 325
aat ttg aaa ctg ctg cca cgc atg gtg atc cgg cat acc tcc cgc aaa 1123
Asn Leu Lys Leu Leu Pro Arg Met Val Ile Arg His Thr Ser Arg Lys
330 335 340
gag gaa ggc cag atc tat atg cca ctg gtt aat gga ttg ctg ttt gta 1171
Glu Glu Gly Gln Ile Tyr Met Pro Leu Val Asn Gly Leu Leu Phe Val
345 350 355
tcc gtg atg gtt gtg gtg ctg gta ttc cga tcc tct gaa agc ctc gcc 1219
Ser Val Met Val Val Val Leu Val Phe Arg Ser Ser Glu Ser Leu Ala
360 365 370
agc gcg tac gga ctt gca gtg acc gga acc ttg gtg ctg gtc agc gtc 1267
Ser Ala Tyr Gly Leu Ala Val Thr Gly Thr Leu Val Leu Val Ser Val
375 380 385
ctg tat ctg atc tat gtt cac acc aca tgg tgg aaa aca gcg ctg ttc 1315
Leu Tyr Leu Ile Tyr Val His Thr Thr Trp Trp Lys Thr Ala Leu Phe
390 395 400 405
att gtg ctc atc ggt att cca gaa gta ctt cta ttc gcc tcg aac acc 1363
Ile Val Leu Ile Gly Ile Pro Glu Val Leu Leu Phe Ala Ser Asn Thr
410 415 420
acg aaa att cac gac ggt ggc tgg ctt cca cta ctt att gcg gcc gtg 1411
Thr Lys Ile His Asp Gly Gly Trp Leu Pro Leu Leu Ile Ala Ala Val
425 430 435
ctc atc gtg gtg atg cgg acc tgg gag tgg gga agt gac cgc gtc aat 1459
Leu Ile Val Val Met Arg Thr Trp Glu Trp Gly Ser Asp Arg Val Asn
440 445 450
cag gaa cgc gca gag ctg gaa ctt ccc atg gat aag ttc ttg gag aaa 1507
Gln Glu Arg Ala Glu Leu Glu Leu Pro Met Asp Lys Phe Leu Glu Lys
455 460 465
ctc gat cag cca cac aat att ggt ctg cgt aaa gtt gcc gaa gtg gca 1555
Leu Asp Gln Pro His Asn Ile Gly Leu Arg Lys Val Ala Glu Val Ala
470 475 480 485
gta ttt cca cat ggc acc agc gat act gtc ccg ttg tca ttg gtt cgc 1603
Val Phe Pro His Gly Thr Ser Asp Thr Val Pro Leu Ser Leu Val Arg
490 495 500
tgc gtg aaa gac ctc aag ctt tta tac cga gag atc gtg atc gtt cga 1651
Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu Ile Val Ile Val Arg
505 510 515
atc gtc caa gaa cac gtt ccg cac gtg cca cca gag gaa cgc gcg gaa 1699
Ile Val Gln Glu His Val Pro His Val Pro Pro Glu Glu Arg Ala Glu
520 525 530
atg gaa gtg ctc cat cac gcc ccg atc aga gtc gtg cga gtt gat ctg 1747
Met Glu Val Leu His His Ala Pro Ile Arg Val Val Arg Val Asp Leu
535 540 545
cac ctt ggt tat ttt gat gag cag aac ctg cct gag cat ctc cat gcc 1795
His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro Glu His Leu His Ala
550 555 560 565
att gac cca aca tgg gat aac gcc acc tac ttc ctg tct gcc ctg act 1843
Ile Asp Pro Thr Trp Asp Asn Ala Thr Tyr Phe Leu Ser Ala Leu Thr
570 575 580
ctt cgg agc agg ttg cct gga aag att gct ggc tgg cgt gat cgt ttg 1891
Leu Arg Ser Arg Leu Pro Gly Lys Ile Ala Gly Trp Arg Asp Arg Leu
585 590 595
tat ctt tcg atg gaa cgt aat cag gca tct cga act gag tct ttc aaa 1939
Tyr Leu Ser Met Glu Arg Asn Gln Ala Ser Arg Thr Glu Ser Phe Lys
600 605 610
ttg caa cca agc aaa acc atc acg gtt gga aca gag ctg cac ctt 1984
Leu Gln Pro Ser Lys Thr Ile Thr Val Gly Thr Glu Leu His Leu
615 620 625
taatcaggca gttgctggcc aac 2007
<210> 666
<211> 628
<212> PRT
<213> Corynebacterium glutamicum
<400> 666
Met Leu Asn Arg Met Lys Ser Ala Arg Pro Lys Ser Val Ala Pro Lys
1 5 10 15
Ser Gly Gln Ala Leu Leu Thr Leu Gly Ala Leu Gly Val Val Phe Gly
20 25 30
Asp Ile Gly Thr Ser Pro Leu Tyr Ser Leu His Thr Ala Phe Ser Met
35 40 45
Gln His Asn Lys Val Glu Val Thr Gln Glu Asn Val Tyr Gly Ile Ile
50 55 60
Ser Met Val Leu Trp Thr Ile Thr Leu Ile Val Thr Val Lys Tyr Val
65 70 75 80
Met Leu Val Thr Arg Ala Asp Asn Gln Gly Gln Gly Gly Ile Leu Ala
85 90 95
Leu Val Ala Leu Leu Lys Asn Arg Gly His Trp Gly Lys Phe Val Ala
100 105 110
Val Ala Gly Met Leu Gly Ala Ala Leu Phe Tyr Gly Asp Val Val Ile
115 120 125
Thr Pro Ala Ile Ser Val Leu Ser Ala Thr Glu Gly Leu Thr Val Ile
130 135 140
Ser Pro Ser Phe Glu Arg Phe Ile Leu Pro Val Ser Leu Ala Val Leu
145 150 155 160
Ile Ala Ile Phe Ala Ile Gln Pro Leu Gly Thr Glu Lys Val Gly Lys
165 170 175
Ala Phe Gly Pro Ile Met Leu Leu Trp Phe Val Thr Leu Ala Gly Leu
180 185 190
Gly Ile Pro Gln Ile Ile Gly His Pro Glu Ile Leu Gln Ser Leu Ser
195 200 205
Pro His Trp Ala Leu Arg Leu Ile Val Ala Glu Pro Phe Gln Ala Phe
210 215 220
Val Leu Leu Gly Ala Val Val Leu Thr Val Thr Gly Ala Glu Ala Leu
225 230 235 240
Tyr Ala Asp Met Gly His Phe Gly Ala Arg Pro Ile Arg Val Ala Trp
245 250 255
Phe Cys Val Val Met Pro Ala Leu Ile Leu Thr Tyr Leu Gly Gln Gly
260 265 270
Ala Leu Val Ile Asn Gln Pro Glu Ala Val Arg Asn Pro Met Phe Tyr
275 280 285
Leu Ala Pro Glu Gly Leu Arg Ile Pro Leu Val Ile Leu Ala Thr Ile
290 295 300
Ala Thr Val Ile Ala Ser Gln Ala Val Ile Ser Gly Ala Tyr Ser Leu
305 310 315 320
Thr Lys Gln Ala Val Asn Leu Lys Leu Leu Pro Arg Met Val Ile Arg
325 330 335
His Thr Ser Arg Lys Glu Glu Gly Gln Ile Tyr Met Pro Leu Val Asn
340 345 350
Gly Leu Leu Phe Val Ser Val Met Val Val Val Leu Val Phe Arg Ser
355 360 365
Ser Glu Ser Leu Ala Ser Ala Tyr Gly Leu Ala Val Thr Gly Thr Leu
370 375 380
Val Leu Val Ser Val Leu Tyr Leu Ile Tyr Val His Thr Thr Trp Trp
385 390 395 400
Lys Thr Ala Leu Phe Ile Val Leu Ile Gly Ile Pro Glu Val Leu Leu
405 410 415
Phe Ala Ser Asn Thr Thr Lys Ile His Asp Gly Gly Trp Leu Pro Leu
420 425 430
Leu Ile Ala Ala Val Leu Ile Val Val Met Arg Thr Trp Glu Trp Gly
435 440 445
Ser Asp Arg Val Asn Gln Glu Arg Ala Glu Leu Glu Leu Pro Met Asp
450 455 460
Lys Phe Leu Glu Lys Leu Asp Gln Pro His Asn Ile Gly Leu Arg Lys
465 470 475 480
Val Ala Glu Val Ala Val Phe Pro His Gly Thr Ser Asp Thr Val Pro
485 490 495
Leu Ser Leu Val Arg Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu
500 505 510
Ile Val Ile Val Arg Ile Val Gln Glu His Val Pro His Val Pro Pro
515 520 525
Glu Glu Arg Ala Glu Met Glu Val Leu His His Ala Pro Ile Arg Val
530 535 540
Val Arg Val Asp Leu His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro
545 550 555 560
Glu His Leu His Ala Ile Asp Pro Thr Trp Asp Asn Ala Thr Tyr Phe
565 570 575
Leu Ser Ala Leu Thr Leu Arg Ser Arg Leu Pro Gly Lys Ile Ala Gly
580 585 590
Trp Arg Asp Arg Leu Tyr Leu Ser Met Glu Arg Asn Gln Ala Ser Arg
595 600 605
Thr Glu Ser Phe Lys Leu Gln Pro Ser Lys Thr Ile Thr Val Gly Thr
610 615 620
Glu Leu His Leu
625
<210> 667
<211> 1656
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1633)
<223> RXA02426
<400> 667
tgcagcagca taatcaggga aaaataggaa ctgtttactg aaaaactgac aaacctgaca 60
gacctgaccc gaagagacct tattcatgac gatattgttc atg ctc att aca ttg 115
Met Leu Ile Thr Leu
1 5
ctg ctc gcc acc gtg att gtg gtg gcc atc ggc gat aaa acc gga ctc 163
Leu Leu Ala Thr Val Ile Val Val Ala Ile Gly Asp Lys Thr Gly Leu
10 15 20
ccc tgg cct gct ttg atg act att gtc gcc gca ggt gga gcg ttg ttg 211
Pro Trp Pro Ala Leu Met Thr Ile Val Ala Ala Gly Gly Ala Leu Leu
25 30 35
cca ttt ttg ccg gaa ttt act atc ccg gcc gat ctg atg ttg cct att 259
Pro Phe Leu Pro Glu Phe Thr Ile Pro Ala Asp Leu Met Leu Pro Ile
40 45 50
ttc att ccg ccg ctg ctg tgg gcg ctg gcg agg aag tca tcg tgg gcg 307
Phe Ile Pro Pro Leu Leu Trp Ala Leu Ala Arg Lys Ser Ser Trp Ala
55 60 65
gtg att agg tcg cag atg tct acc atc atc acg atg tcg gtg ttg ttg 355
Val Ile Arg Ser Gln Met Ser Thr Ile Ile Thr Met Ser Val Leu Leu
70 75 80 85
gtg ttc gtg acc atc gcg gca ctc acg ggt gca tcc atg ctg ttg ctt 403
Val Phe Val Thr Ile Ala Ala Leu Thr Gly Ala Ser Met Leu Leu Leu
90 95 100
cct ggc att ggt ctt gct ggt gcg atc atg ttg gct gcg gct att gct 451
Pro Gly Ile Gly Leu Ala Gly Ala Ile Met Leu Ala Ala Ala Ile Ala
105 110 115
cca ccg gat cct gtt gct gtt gat gca gtg gcg gaa cct gcg gga atc 499
Pro Pro Asp Pro Val Ala Val Asp Ala Val Ala Glu Pro Ala Gly Ile
120 125 130
ccg aag cgc atc acc acc act ttg cag acg gag ggt ctg ttt aat gat 547
Pro Lys Arg Ile Thr Thr Thr Leu Gln Thr Glu Gly Leu Phe Asn Asp
135 140 145
gca gcc agc atc gtg gcg ttc cat gtg gct tta gct gcc ctg gtc gct 595
Ala Ala Ser Ile Val Ala Phe His Val Ala Leu Ala Ala Leu Val Ala
150 155 160 165
ggt gag gat ttg tcc tgg tca acg ggt gtt ttg gaa ttc ttg tgg tcg 643
Gly Glu Asp Leu Ser Trp Ser Thr Gly Val Leu Glu Phe Leu Trp Ser
170 175 180
tgt ctt gct gcc gtt att ttg ggc ttg gtt att ggc cgg gcg gct gcg 691
Cys Leu Ala Ala Val Ile Leu Gly Leu Val Ile Gly Arg Ala Ala Ala
185 190 195
tgg ttt acc gat cac gtg agt tcc gtt gag gct cga aat gcg ttt acg 739
Trp Phe Thr Asp His Val Ser Ser Val Glu Ala Arg Asn Ala Phe Thr
200 205 210
tgg gtg ctg ccg ttt gcc att tat gtg gtg gcg gaa gaa atc ggc gga 787
Trp Val Leu Pro Phe Ala Ile Tyr Val Val Ala Glu Glu Ile Gly Gly
215 220 225
tcg ggc gtt atc gcc att gtg atc gct gca gtg gag atg aat tcg agg 835
Ser Gly Val Ile Ala Ile Val Ile Ala Ala Val Glu Met Asn Ser Arg
230 235 240 245
gcg tcg att ggt gcg gag gat cgt cta acg ggt tct gcg ttc tgg gga 883
Ala Ser Ile Gly Ala Glu Asp Arg Leu Thr Gly Ser Ala Phe Trp Gly
250 255 260
acc att gag gtg ctg ttt act ggc gtt gcc ttt ggt ttg atc ggc ctg 931
Thr Ile Glu Val Leu Phe Thr Gly Val Ala Phe Gly Leu Ile Gly Leu
265 270 275
aat gtg cgc gct gcg att gat gaa gtt gga tct gag ctg tgg cat gcc 979
Asn Val Arg Ala Ala Ile Asp Glu Val Gly Ser Glu Leu Trp His Ala
280 285 290
gtg gtc gtg ggc att gtg ctc tcg gtg gtg gcg atc gtt gtc cgt ggt 1027
Val Val Val Gly Ile Val Leu Ser Val Val Ala Ile Val Val Arg Gly
295 300 305
gtg tgg atg ttc gcg gcg tat aag cgc aat cgt ttc aag atc gat aag 1075
Val Trp Met Phe Ala Ala Tyr Lys Arg Asn Arg Phe Lys Ile Asp Lys
310 315 320 325
aag ggt gcg acc aat agt tca ttg cgg gcg cct ctt cga ctg cag gaa 1123
Lys Gly Ala Thr Asn Ser Ser Leu Arg Ala Pro Leu Arg Leu Gln Glu
330 335 340
tcg ttg ctg atg acg tgg gcg ggc atg cgc ggt ttg gtg acg ttg gcg 1171
Ser Leu Leu Met Thr Trp Ala Gly Met Arg Gly Leu Val Thr Leu Ala
345 350 355
ctg gtg ctg tct att ccg gag gat att ttc ccg tat cac cac gag ttg 1219
Leu Val Leu Ser Ile Pro Glu Asp Ile Phe Pro Tyr His His Glu Leu
360 365 370
cag gtc att gcg ctg gtc gtt ctc tta atc acc atg gtg ggc cct ggt 1267
Gln Val Ile Ala Leu Val Val Leu Leu Ile Thr Met Val Gly Pro Gly
375 380 385
ttg acg ttg ccg tgg ctg atg cgg aag ctc agc ttg gat aag ggt ccc 1315
Leu Thr Leu Pro Trp Leu Met Arg Lys Leu Ser Leu Asp Lys Gly Pro
390 395 400 405
gat gct gcg ggc gat gag agt atc gcc gcg ctg aca gag agg gct cac 1363
Asp Ala Ala Gly Asp Glu Ser Ile Ala Ala Leu Thr Glu Arg Ala His
410 415 420
aag gcc gca aca acg tat ttg gtg gat acc acg gag ttg ccg atg gag 1411
Lys Ala Ala Thr Thr Tyr Leu Val Asp Thr Thr Glu Leu Pro Met Glu
425 430 435
cag atg gtg gcg atc aag aat tgg ttc tcg caa gaa att gac gct gat 1459
Gln Met Val Ala Ile Lys Asn Trp Phe Ser Gln Glu Ile Asp Ala Asp
440 445 450
gaa ctg cag gag aac gtc gat aag ctg cat cag cgc gcg cat cat gcg 1507
Glu Leu Gln Glu Asn Val Asp Lys Leu His Gln Arg Ala His His Ala
455 460 465
cgt gtc ggg gca att aag gcg gcc cag gag gag ctg ttg aag gcg cgg 1555
Arg Val Gly Ala Ile Lys Ala Ala Gln Glu Glu Leu Leu Lys Ala Arg
470 475 480 485
cgg gag cgc ggc gtt aat ccg gcc tat gtt gat gag gtg ttg acc aac 1603
Arg Glu Arg Gly Val Asn Pro Ala Tyr Val Asp Glu Val Leu Thr Asn
490 495 500
att gac cgg atg ctt gtt gcg gct gaa cgc tagataaaca gcagcaggct 1653
Ile Asp Arg Met Leu Val Ala Ala Glu Arg
505 510
gat 1656
<210> 668
<211> 511
<212> PRT
<213> Corynebacterium glutamicum
<400> 668
Met Leu Ile Thr Leu Leu Leu Ala Thr Val Ile Val Val Ala Ile Gly
1 5 10 15
Asp Lys Thr Gly Leu Pro Trp Pro Ala Leu Met Thr Ile Val Ala Ala
20 25 30
Gly Gly Ala Leu Leu Pro Phe Leu Pro Glu Phe Thr Ile Pro Ala Asp
35 40 45
Leu Met Leu Pro Ile Phe Ile Pro Pro Leu Leu Trp Ala Leu Ala Arg
50 55 60
Lys Ser Ser Trp Ala Val Ile Arg Ser Gln Met Ser Thr Ile Ile Thr
65 70 75 80
Met Ser Val Leu Leu Val Phe Val Thr Ile Ala Ala Leu Thr Gly Ala
85 90 95
Ser Met Leu Leu Leu Pro Gly Ile Gly Leu Ala Gly Ala Ile Met Leu
100 105 110
Ala Ala Ala Ile Ala Pro Pro Asp Pro Val Ala Val Asp Ala Val Ala
115 120 125
Glu Pro Ala Gly Ile Pro Lys Arg Ile Thr Thr Thr Leu Gln Thr Glu
130 135 140
Gly Leu Phe Asn Asp Ala Ala Ser Ile Val Ala Phe His Val Ala Leu
145 150 155 160
Ala Ala Leu Val Ala Gly Glu Asp Leu Ser Trp Ser Thr Gly Val Leu
165 170 175
Glu Phe Leu Trp Ser Cys Leu Ala Ala Val Ile Leu Gly Leu Val Ile
180 185 190
Gly Arg Ala Ala Ala Trp Phe Thr Asp His Val Ser Ser Val Glu Ala
195 200 205
Arg Asn Ala Phe Thr Trp Val Leu Pro Phe Ala Ile Tyr Val Val Ala
210 215 220
Glu Glu Ile Gly Gly Ser Gly Val Ile Ala Ile Val Ile Ala Ala Val
225 230 235 240
Glu Met Asn Ser Arg Ala Ser Ile Gly Ala Glu Asp Arg Leu Thr Gly
245 250 255
Ser Ala Phe Trp Gly Thr Ile Glu Val Leu Phe Thr Gly Val Ala Phe
260 265 270
Gly Leu Ile Gly Leu Asn Val Arg Ala Ala Ile Asp Glu Val Gly Ser
275 280 285
Glu Leu Trp His Ala Val Val Val Gly Ile Val Leu Ser Val Val Ala
290 295 300
Ile Val Val Arg Gly Val Trp Met Phe Ala Ala Tyr Lys Arg Asn Arg
305 310 315 320
Phe Lys Ile Asp Lys Lys Gly Ala Thr Asn Ser Ser Leu Arg Ala Pro
325 330 335
Leu Arg Leu Gln Glu Ser Leu Leu Met Thr Trp Ala Gly Met Arg Gly
340 345 350
Leu Val Thr Leu Ala Leu Val Leu Ser Ile Pro Glu Asp Ile Phe Pro
355 360 365
Tyr His His Glu Leu Gln Val Ile Ala Leu Val Val Leu Leu Ile Thr
370 375 380
Met Val Gly Pro Gly Leu Thr Leu Pro Trp Leu Met Arg Lys Leu Ser
385 390 395 400
Leu Asp Lys Gly Pro Asp Ala Ala Gly Asp Glu Ser Ile Ala Ala Leu
405 410 415
Thr Glu Arg Ala His Lys Ala Ala Thr Thr Tyr Leu Val Asp Thr Thr
420 425 430
Glu Leu Pro Met Glu Gln Met Val Ala Ile Lys Asn Trp Phe Ser Gln
435 440 445
Glu Ile Asp Ala Asp Glu Leu Gln Glu Asn Val Asp Lys Leu His Gln
450 455 460
Arg Ala His His Ala Arg Val Gly Ala Ile Lys Ala Ala Gln Glu Glu
465 470 475 480
Leu Leu Lys Ala Arg Arg Glu Arg Gly Val Asn Pro Ala Tyr Val Asp
485 490 495
Glu Val Leu Thr Asn Ile Asp Arg Met Leu Val Ala Ala Glu Arg
500 505 510
<210> 669
<211> 993
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(970)
<223> RXN03164
<400> 669
cttttttgca tccagatgca caaagccgtg gcacaaacga gacaaactga gcacaatggc 60
tgtcatggca tatcaaccag cagacaatcg ctatgacgac atg atc tac cgc agg 115
Met Ile Tyr Arg Arg
1 5
gtg gga aat tct ggg ctg aag ctt ccg gca att tcg ctt ggg ctg tgg 163
Val Gly Asn Ser Gly Leu Lys Leu Pro Ala Ile Ser Leu Gly Leu Trp
10 15 20
cac aac ttc ggt gat gac aag ccg ctt tca acg cag cgc agc att att 211
His Asn Phe Gly Asp Asp Lys Pro Leu Ser Thr Gln Arg Ser Ile Ile
25 30 35
cac cgc gcg ttt gat agg gga gtc act cac ttc gat ttg gct aat aac 259
His Arg Ala Phe Asp Arg Gly Val Thr His Phe Asp Leu Ala Asn Asn
40 45 50
tat gga cct cca gca ggt tcc gca gag acc aac ttt ggc agg att ttg 307
Tyr Gly Pro Pro Ala Gly Ser Ala Glu Thr Asn Phe Gly Arg Ile Leu
55 60 65
cgt gag gat ctc aaa agc cac cgc gat gag ttg atc att tct tcc aag 355
Arg Glu Asp Leu Lys Ser His Arg Asp Glu Leu Ile Ile Ser Ser Lys
70 75 80 85
gcg ggt tgg gat atg tgg cct gga cct tat ggt ttt ggt ggt tcc cga 403
Ala Gly Trp Asp Met Trp Pro Gly Pro Tyr Gly Phe Gly Gly Ser Arg
90 95 100
aag tat cta gtg agt tcc ctt gat cag tcc ctg act cgc ctc ggc ttg 451
Lys Tyr Leu Val Ser Ser Leu Asp Gln Ser Leu Thr Arg Leu Gly Leu
105 110 115
gat tac gtg gat att ttc tat cat cac cgc ccg gat cca gat act cct 499
Asp Tyr Val Asp Ile Phe Tyr His His Arg Pro Asp Pro Asp Thr Pro
120 125 130
ttg gaa gaa acc atg tac gca ttg cgt gac att gtt gcg tct gga aag 547
Leu Glu Glu Thr Met Tyr Ala Leu Arg Asp Ile Val Ala Ser Gly Lys
135 140 145
gct ctt tac gtg ggt att tct tcc tac ggt cca gag ctc aca gcg gag 595
Ala Leu Tyr Val Gly Ile Ser Ser Tyr Gly Pro Glu Leu Thr Ala Glu
150 155 160 165
gcg gct gag ttc atg gcg gag gag ggc tgc ccg ctt ctg att cat cag 643
Ala Ala Glu Phe Met Ala Glu Glu Gly Cys Pro Leu Leu Ile His Gln
170 175 180
cca agc tat tcc atc att aat cgt tgg gtg gag gaa ccg ggc gat gac 691
Pro Ser Tyr Ser Ile Ile Asn Arg Trp Val Glu Glu Pro Gly Asp Asp
185 190 195
ggt gag aac ttg ttg cag tca gct gcc aac aat ggt ctt ggc gtc att 739
Gly Glu Asn Leu Leu Gln Ser Ala Ala Asn Asn Gly Leu Gly Val Ile
200 205 210
gct ttc tca cca ctt gcg cag ggc ctg ctc acg gac aaa tat ctc gat 787
Ala Phe Ser Pro Leu Ala Gln Gly Leu Leu Thr Asp Lys Tyr Leu Asp
215 220 225
gga att cca gag ggt tcc cgc gcc agc cag ggt aag tcc ctg tct gag 835
Gly Ile Pro Glu Gly Ser Arg Ala Ser Gln Gly Lys Ser Leu Ser Glu
230 235 240 245
ggc atg ttg aac gtg aac aat att gat atg gtc cgc aag ctc aat gac 883
Gly Met Leu Asn Val Asn Asn Ile Asp Met Val Arg Lys Leu Asn Asp
250 255 260
atc gcc cag gaa cgc ggg cag tca ctt gcg cag atg gcg ctt gca tgg 931
Ile Ala Gln Glu Arg Gly Gln Ser Leu Ala Gln Met Ala Leu Ala Trp
265 270 275
gtg ctg cgc gag caa aga gag tac ggc gcc gga tta ccg tgaccagtgc 980
Val Leu Arg Glu Gln Arg Glu Tyr Gly Ala Gly Leu Pro
280 285 290
attgattggt gct 993
<210> 670
<211> 290
<212> PRT
<213> Corynebacterium glutamicum
<400> 670
Met Ile Tyr Arg Arg Val Gly Asn Ser Gly Leu Lys Leu Pro Ala Ile
1 5 10 15
Ser Leu Gly Leu Trp His Asn Phe Gly Asp Asp Lys Pro Leu Ser Thr
20 25 30
Gln Arg Ser Ile Ile His Arg Ala Phe Asp Arg Gly Val Thr His Phe
35 40 45
Asp Leu Ala Asn Asn Tyr Gly Pro Pro Ala Gly Ser Ala Glu Thr Asn
50 55 60
Phe Gly Arg Ile Leu Arg Glu Asp Leu Lys Ser His Arg Asp Glu Leu
65 70 75 80
Ile Ile Ser Ser Lys Ala Gly Trp Asp Met Trp Pro Gly Pro Tyr Gly
85 90 95
Phe Gly Gly Ser Arg Lys Tyr Leu Val Ser Ser Leu Asp Gln Ser Leu
100 105 110
Thr Arg Leu Gly Leu Asp Tyr Val Asp Ile Phe Tyr His His Arg Pro
115 120 125
Asp Pro Asp Thr Pro Leu Glu Glu Thr Met Tyr Ala Leu Arg Asp Ile
130 135 140
Val Ala Ser Gly Lys Ala Leu Tyr Val Gly Ile Ser Ser Tyr Gly Pro
145 150 155 160
Glu Leu Thr Ala Glu Ala Ala Glu Phe Met Ala Glu Glu Gly Cys Pro
165 170 175
Leu Leu Ile His Gln Pro Ser Tyr Ser Ile Ile Asn Arg Trp Val Glu
180 185 190
Glu Pro Gly Asp Asp Gly Glu Asn Leu Leu Gln Ser Ala Ala Asn Asn
195 200 205
Gly Leu Gly Val Ile Ala Phe Ser Pro Leu Ala Gln Gly Leu Leu Thr
210 215 220
Asp Lys Tyr Leu Asp Gly Ile Pro Glu Gly Ser Arg Ala Ser Gln Gly
225 230 235 240
Lys Ser Leu Ser Glu Gly Met Leu Asn Val Asn Asn Ile Asp Met Val
245 250 255
Arg Lys Leu Asn Asp Ile Ala Gln Glu Arg Gly Gln Ser Leu Ala Gln
260 265 270
Met Ala Leu Ala Trp Val Leu Arg Glu Gln Arg Glu Tyr Gly Ala Gly
275 280 285
Leu Pro
290
<210> 671
<211> 1068
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1045)
<223> RXN00024
<400> 671
ttaagacatc aacatatggc ttgtgctact gaaagatttt tcttctgaaa ttctgtagaa 60
acgctcctat gctcggggca gtaagttgtg agcataggaa atg gag cac ggc gtg 115
Met Glu His Gly Val
1 5
acc gtt att aaa ggc act gaa ttt gat gtt ttc cca cta aac ctc ggt 163
Thr Val Ile Lys Gly Thr Glu Phe Asp Val Phe Pro Leu Asn Leu Gly
10 15 20
gga aat acc ttt ggc tgg acc tcg aat agg gaa cag acc ttc gcg gtt 211
Gly Asn Thr Phe Gly Trp Thr Ser Asn Arg Glu Gln Thr Phe Ala Val
25 30 35
ttg gat gca ttc gtg gca gcg gga gga aac ttt gtt gac acc gcc gat 259
Leu Asp Ala Phe Val Ala Ala Gly Gly Asn Phe Val Asp Thr Ala Asp
40 45 50
tct tat tct gca tgg gtt gaa ggc aat gag ggt ggc gag tcg gag cgg 307
Ser Tyr Ser Ala Trp Val Glu Gly Asn Glu Gly Gly Glu Ser Glu Arg
55 60 65
gag ctc ggc gcg tgg att aag gaa cgt ggc gca gac aag ctg atc att 355
Glu Leu Gly Ala Trp Ile Lys Glu Arg Gly Ala Asp Lys Leu Ile Ile
70 75 80 85
gct acc aag tct ggt gcg ttg gag cct gtt gct ggt cgt tcc cgt gag 403
Ala Thr Lys Ser Gly Ala Leu Glu Pro Val Ala Gly Arg Ser Arg Glu
90 95 100
gca act ttc aag gct gtc gag ggt tcc ctg gag cgt ttg ggc gtg gaa 451
Ala Thr Phe Lys Ala Val Glu Gly Ser Leu Glu Arg Leu Gly Val Glu
105 110 115
tcg atc gat att ttt tac tac cac tac gac gat gag gca gtc agc att 499
Ser Ile Asp Ile Phe Tyr Tyr His Tyr Asp Asp Glu Ala Val Ser Ile
120 125 130
gat gag cag gtt gct atc gct aat gat ctg att gca cag ggc aag att 547
Asp Glu Gln Val Ala Ile Ala Asn Asp Leu Ile Ala Gln Gly Lys Ile
135 140 145
aag cac ctc gca ttg tct aac tac agc gcg gag cgt tta gct gag ttc 595
Lys His Leu Ala Leu Ser Asn Tyr Ser Ala Glu Arg Leu Ala Glu Phe
150 155 160 165
ttt gag aag tct gta ggc act cca gcg cag ccg gtt gct ctg caa ccg 643
Phe Glu Lys Ser Val Gly Thr Pro Ala Gln Pro Val Ala Leu Gln Pro
170 175 180
cac tac aac ctg gtg tcg agg aag gat tat gag gag aac gtg cag cca 691
His Tyr Asn Leu Val Ser Arg Lys Asp Tyr Glu Glu Asn Val Gln Pro
185 190 195
ctc gcc gag aag cat ggc gtt gca gtc ttc cct tat ttc gcg ctt gcc 739
Leu Ala Glu Lys His Gly Val Ala Val Phe Pro Tyr Phe Ala Leu Ala
200 205 210
gcg ggt ctt ttg acc gga aag tac acc tcc aag gag gat att tcg ggt 787
Ala Gly Leu Leu Thr Gly Lys Tyr Thr Ser Lys Glu Asp Ile Ser Gly
215 220 225
aaa gcg cgt gcg ggg cag ttg gat cgt tac gcc agc gat gag gcg ttt 835
Lys Ala Arg Ala Gly Gln Leu Asp Arg Tyr Ala Ser Asp Glu Ala Phe
230 235 240 245
gcc gtg gtg aca gag ttg cgt gct gtt gcc gat gag ttg ggt gtt gcg 883
Ala Val Val Thr Glu Leu Arg Ala Val Ala Asp Glu Leu Gly Val Ala
250 255 260
cca acg act gtg gcg ctt gcg tgg ttg gtt gcg cat ggt gtg acc gca 931
Pro Thr Thr Val Ala Leu Ala Trp Leu Val Ala His Gly Val Thr Ala
265 270 275
ccg att gcg tcc gtg tcc aag gta gag cag ttg aag gat ttg atg gct 979
Pro Ile Ala Ser Val Ser Lys Val Glu Gln Leu Lys Asp Leu Met Ala
280 285 290
gtg aag gat gtg gag ctg agc gct gag cag ctt gca cgt ttg gat aag 1027
Val Lys Asp Val Glu Leu Ser Ala Glu Gln Leu Ala Arg Leu Asp Lys
295 300 305
gtt tcg gag cct ttc gct taagctctcc tcaaaagtaa gtg 1068
Val Ser Glu Pro Phe Ala
310 315
<210> 672
<211> 315
<212> PRT
<213> Corynebacterium glutamicum
<400> 672
Met Glu His Gly Val Thr Val Ile Lys Gly Thr Glu Phe Asp Val Phe
1 5 10 15
Pro Leu Asn Leu Gly Gly Asn Thr Phe Gly Trp Thr Ser Asn Arg Glu
20 25 30
Gln Thr Phe Ala Val Leu Asp Ala Phe Val Ala Ala Gly Gly Asn Phe
35 40 45
Val Asp Thr Ala Asp Ser Tyr Ser Ala Trp Val Glu Gly Asn Glu Gly
50 55 60
Gly Glu Ser Glu Arg Glu Leu Gly Ala Trp Ile Lys Glu Arg Gly Ala
65 70 75 80
Asp Lys Leu Ile Ile Ala Thr Lys Ser Gly Ala Leu Glu Pro Val Ala
85 90 95
Gly Arg Ser Arg Glu Ala Thr Phe Lys Ala Val Glu Gly Ser Leu Glu
100 105 110
Arg Leu Gly Val Glu Ser Ile Asp Ile Phe Tyr Tyr His Tyr Asp Asp
115 120 125
Glu Ala Val Ser Ile Asp Glu Gln Val Ala Ile Ala Asn Asp Leu Ile
130 135 140
Ala Gln Gly Lys Ile Lys His Leu Ala Leu Ser Asn Tyr Ser Ala Glu
145 150 155 160
Arg Leu Ala Glu Phe Phe Glu Lys Ser Val Gly Thr Pro Ala Gln Pro
165 170 175
Val Ala Leu Gln Pro His Tyr Asn Leu Val Ser Arg Lys Asp Tyr Glu
180 185 190
Glu Asn Val Gln Pro Leu Ala Glu Lys His Gly Val Ala Val Phe Pro
195 200 205
Tyr Phe Ala Leu Ala Ala Gly Leu Leu Thr Gly Lys Tyr Thr Ser Lys
210 215 220
Glu Asp Ile Ser Gly Lys Ala Arg Ala Gly Gln Leu Asp Arg Tyr Ala
225 230 235 240
Ser Asp Glu Ala Phe Ala Val Val Thr Glu Leu Arg Ala Val Ala Asp
245 250 255
Glu Leu Gly Val Ala Pro Thr Thr Val Ala Leu Ala Trp Leu Val Ala
260 265 270
His Gly Val Thr Ala Pro Ile Ala Ser Val Ser Lys Val Glu Gln Leu
275 280 285
Lys Asp Leu Met Ala Val Lys Asp Val Glu Leu Ser Ala Glu Gln Leu
290 295 300
Ala Arg Leu Asp Lys Val Ser Glu Pro Phe Ala
305 310 315
<210> 673
<211> 1758
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(1735)
<223> RXN01164
<400> 673
gccgatcgtg attgatgaag acgagatcca agcctggact tctgatctca aacctgaaga 60
tttcaccaaa ggtaaagatg aatccgacgg tgagaaataa gtg aca ctg ttt gtt 115
Val Thr Leu Phe Val
1 5
cgg ctc gcc ctt gct gct gtg ggc ggg ctt ttt gtc ttt gct tcc aat 163
Arg Leu Ala Leu Ala Ala Val Gly Gly Leu Phe Val Phe Ala Ser Asn
10 15 20
gaa ccg atc ggc tgg ttt gtc gcg gga att gtt ggc act gca tta ttt 211
Glu Pro Ile Gly Trp Phe Val Ala Gly Ile Val Gly Thr Ala Leu Phe
25 30 35
ttt atc tcc ctt gcg ccg tgg gat ctg gga gtt ccc caa aag cgg cgg 259
Phe Ile Ser Leu Ala Pro Trp Asp Leu Gly Val Pro Gln Lys Arg Arg
40 45 50
aag aag aat gag cca gtc cca ttt ttg caa cag atg tcc acg ggc cca 307
Lys Lys Asn Glu Pro Val Pro Phe Leu Gln Gln Met Ser Thr Gly Pro
55 60 65
act gtt gta cag ggc atg ctt tta ggt ttt gtc cat ggc ctg gtg aca 355
Thr Val Val Gln Gly Met Leu Leu Gly Phe Val His Gly Leu Val Thr
70 75 80 85
tat ttg cag ctg ttg ccg tgg atc ggt gag ttt gtt ggc tca ctg cct 403
Tyr Leu Gln Leu Leu Pro Trp Ile Gly Glu Phe Val Gly Ser Leu Pro
90 95 100
tat gtc gcg ttg tca gtt gtc gag gcg ctt tat tcc att gct ctt ggt 451
Tyr Val Ala Leu Ser Val Val Glu Ala Leu Tyr Ser Ile Ala Leu Gly
105 110 115
gct ttc ggc gtg ctc att gcg cgt tgg agg gac tgg aag gtt ctc ctg 499
Ala Phe Gly Val Leu Ile Ala Arg Trp Arg Asp Trp Lys Val Leu Leu
120 125 130
ttt ccg gcg atg tat gtg gct gtg gag tat cta aga agc tcg tgg cca 547
Phe Pro Ala Met Tyr Val Ala Val Glu Tyr Leu Arg Ser Ser Trp Pro
135 140 145
ttt gat gga ttc gcg tgg gtt cgc ctg gca tgg ggt caa att aac ggt 595
Phe Asp Gly Phe Ala Trp Val Arg Leu Ala Trp Gly Gln Ile Asn Gly
150 155 160 165
ccg ttg gct aat ctc gca gcg ctt ggt ggg gta gcg ttt gtc act ttt 643
Pro Leu Ala Asn Leu Ala Ala Leu Gly Gly Val Ala Phe Val Thr Phe
170 175 180
tcc acg gtg ctg gct gcc gtg ggt gtg gcc atg gtg att att tcc aag 691
Ser Thr Val Leu Ala Ala Val Gly Val Ala Met Val Ile Ile Ser Lys
185 190 195
aag cga ctg gcc ggc gca atc atc acc gcg agt gtg att gct atc ggc 739
Lys Arg Leu Ala Gly Ala Ile Ile Thr Ala Ser Val Ile Ala Ile Gly
200 205 210
gcg gtg tca tcc ctg tac gtt gac cgc aat ggc acg agc gat gaa agc 787
Ala Val Ser Ser Leu Tyr Val Asp Arg Asn Gly Thr Ser Asp Glu Ser
215 220 225
atc gaa gta gcc gca att cag ggc aat gtg cct cgg atg gga ttg gac 835
Ile Glu Val Ala Ala Ile Gln Gly Asn Val Pro Arg Met Gly Leu Asp
230 235 240 245
ttc aat gca cag cgc cgc gcg gtg ctg gcg aat cac gca cgg gaa acc 883
Phe Asn Ala Gln Arg Arg Ala Val Leu Ala Asn His Ala Arg Glu Thr
250 255 260
ctc aag ctg gat gaa caa gtg gat ttg gtg atc tgg ccg gag aat tcc 931
Leu Lys Leu Asp Glu Gln Val Asp Leu Val Ile Trp Pro Glu Asn Ser
265 270 275
tca gac gtc aac cca ttt tcc gat gca caa gca aga gcc att atc gat 979
Ser Asp Val Asn Pro Phe Ser Asp Ala Gln Ala Arg Ala Ile Ile Asp
280 285 290
gga gca gtg gaa cat gtt cag gca cct att ttg gtg ggc acg atc acc 1027
Gly Ala Val Glu His Val Gln Ala Pro Ile Leu Val Gly Thr Ile Thr
295 300 305
gtc gat gag gtt ggt cca cgc aac acc atg cag gta ttt gat cct gtt 1075
Val Asp Glu Val Gly Pro Arg Asn Thr Met Gln Val Phe Asp Pro Val
310 315 320 325
gaa ggt gcc gcg gag tac cac aat aag aag ttc ttg cag ccg ttt ggt 1123
Glu Gly Ala Ala Glu Tyr His Asn Lys Lys Phe Leu Gln Pro Phe Gly
330 335 340
gaa tac atg ccg ttt cgc gaa ttc ctg aga att ttc tcg ccc tac gtt 1171
Glu Tyr Met Pro Phe Arg Glu Phe Leu Arg Ile Phe Ser Pro Tyr Val
345 350 355
gat tcc gct gga aac ttc cag ccc ggt gat ggc acc ggc gta gtg gag 1219
Asp Ser Ala Gly Asn Phe Gln Pro Gly Asp Gly Thr Gly Val Val Glu
360 365 370
atg aat gct gcg aac tta ggc cgc gct gtg aca gtg ggc gtg atg acg 1267
Met Asn Ala Ala Asn Leu Gly Arg Ala Val Thr Val Gly Val Met Thr
375 380 385
tgt tac gag gtc atc ttc gac cgt gct ggc cgc gac gcc atc gcc aat 1315
Cys Tyr Glu Val Ile Phe Asp Arg Ala Gly Arg Asp Ala Ile Ala Asn
390 395 400 405
ggg gct gaa ttt ttg acc acg ccc acc aac aac gcc acc ttc gga ttc 1363
Gly Ala Glu Phe Leu Thr Thr Pro Thr Asn Asn Ala Thr Phe Gly Phe
410 415 420
acg gac atg acg tat cag caa tta gca atg agc agg atg cgt gcc atc 1411
Thr Asp Met Thr Tyr Gln Gln Leu Ala Met Ser Arg Met Arg Ala Ile
425 430 435
gaa ttt gat agg gcg gtg gtt gtt gca gct aca tcg ggt gtt tcg gct 1459
Glu Phe Asp Arg Ala Val Val Val Ala Ala Thr Ser Gly Val Ser Ala
440 445 450
atc gtc aac cct gat gga agc att tcc caa aac acc cga att ttt gag 1507
Ile Val Asn Pro Asp Gly Ser Ile Ser Gln Asn Thr Arg Ile Phe Glu
455 460 465
gcc gcc acc ttg acg gaa tcc att cca ctc aag gac act gtc acc atc 1555
Ala Ala Thr Leu Thr Glu Ser Ile Pro Leu Lys Asp Thr Val Thr Ile
470 475 480 485
gca gcg cgg gtt ggt ttc tat gtt gaa tta ctg ttg gtt atc att ggt 1603
Ala Ala Arg Val Gly Phe Tyr Val Glu Leu Leu Leu Val Ile Ile Gly
490 495 500
gta tta gct gga cta ttc gcc att cga atg aat agc cgt tca aag tct 1651
Val Leu Ala Gly Leu Phe Ala Ile Arg Met Asn Ser Arg Ser Lys Ser
505 510 515
gcg aaa ggt tcc gct cgg ccc gca caa gtt cgg gtt aag aag gtg cct 1699
Ala Lys Gly Ser Ala Arg Pro Ala Gln Val Arg Val Lys Lys Val Pro
520 525 530
gcg aaa aag gca gca act aat cgt cga aaa gta aaa taaaaacgtc 1745
Ala Lys Lys Ala Ala Thr Asn Arg Arg Lys Val Lys
535 540 545
ccgaagggac gag 1758
<210> 674
<211> 545
<212> PRT
<213> Corynebacterium glutamicum
<400> 674
Val Thr Leu Phe Val Arg Leu Ala Leu Ala Ala Val Gly Gly Leu Phe
1 5 10 15
Val Phe Ala Ser Asn Glu Pro Ile Gly Trp Phe Val Ala Gly Ile Val
20 25 30
Gly Thr Ala Leu Phe Phe Ile Ser Leu Ala Pro Trp Asp Leu Gly Val
35 40 45
Pro Gln Lys Arg Arg Lys Lys Asn Glu Pro Val Pro Phe Leu Gln Gln
50 55 60
Met Ser Thr Gly Pro Thr Val Val Gln Gly Met Leu Leu Gly Phe Val
65 70 75 80
His Gly Leu Val Thr Tyr Leu Gln Leu Leu Pro Trp Ile Gly Glu Phe
85 90 95
Val Gly Ser Leu Pro Tyr Val Ala Leu Ser Val Val Glu Ala Leu Tyr
100 105 110
Ser Ile Ala Leu Gly Ala Phe Gly Val Leu Ile Ala Arg Trp Arg Asp
115 120 125
Trp Lys Val Leu Leu Phe Pro Ala Met Tyr Val Ala Val Glu Tyr Leu
130 135 140
Arg Ser Ser Trp Pro Phe Asp Gly Phe Ala Trp Val Arg Leu Ala Trp
145 150 155 160
Gly Gln Ile Asn Gly Pro Leu Ala Asn Leu Ala Ala Leu Gly Gly Val
165 170 175
Ala Phe Val Thr Phe Ser Thr Val Leu Ala Ala Val Gly Val Ala Met
180 185 190
Val Ile Ile Ser Lys Lys Arg Leu Ala Gly Ala Ile Ile Thr Ala Ser
195 200 205
Val Ile Ala Ile Gly Ala Val Ser Ser Leu Tyr Val Asp Arg Asn Gly
210 215 220
Thr Ser Asp Glu Ser Ile Glu Val Ala Ala Ile Gln Gly Asn Val Pro
225 230 235 240
Arg Met Gly Leu Asp Phe Asn Ala Gln Arg Arg Ala Val Leu Ala Asn
245 250 255
His Ala Arg Glu Thr Leu Lys Leu Asp Glu Gln Val Asp Leu Val Ile
260 265 270
Trp Pro Glu Asn Ser Ser Asp Val Asn Pro Phe Ser Asp Ala Gln Ala
275 280 285
Arg Ala Ile Ile Asp Gly Ala Val Glu His Val Gln Ala Pro Ile Leu
290 295 300
Val Gly Thr Ile Thr Val Asp Glu Val Gly Pro Arg Asn Thr Met Gln
305 310 315 320
Val Phe Asp Pro Val Glu Gly Ala Ala Glu Tyr His Asn Lys Lys Phe
325 330 335
Leu Gln Pro Phe Gly Glu Tyr Met Pro Phe Arg Glu Phe Leu Arg Ile
340 345 350
Phe Ser Pro Tyr Val Asp Ser Ala Gly Asn Phe Gln Pro Gly Asp Gly
355 360 365
Thr Gly Val Val Glu Met Asn Ala Ala Asn Leu Gly Arg Ala Val Thr
370 375 380
Val Gly Val Met Thr Cys Tyr Glu Val Ile Phe Asp Arg Ala Gly Arg
385 390 395 400
Asp Ala Ile Ala Asn Gly Ala Glu Phe Leu Thr Thr Pro Thr Asn Asn
405 410 415
Ala Thr Phe Gly Phe Thr Asp Met Thr Tyr Gln Gln Leu Ala Met Ser
420 425 430
Arg Met Arg Ala Ile Glu Phe Asp Arg Ala Val Val Val Ala Ala Thr
435 440 445
Ser Gly Val Ser Ala Ile Val Asn Pro Asp Gly Ser Ile Ser Gln Asn
450 455 460
Thr Arg Ile Phe Glu Ala Ala Thr Leu Thr Glu Ser Ile Pro Leu Lys
465 470 475 480
Asp Thr Val Thr Ile Ala Ala Arg Val Gly Phe Tyr Val Glu Leu Leu
485 490 495
Leu Val Ile Ile Gly Val Leu Ala Gly Leu Phe Ala Ile Arg Met Asn
500 505 510
Ser Arg Ser Lys Ser Ala Lys Gly Ser Ala Arg Pro Ala Gln Val Arg
515 520 525
Val Lys Lys Val Pro Ala Lys Lys Ala Ala Thr Asn Arg Arg Lys Val
530 535 540
Lys
545
<210> 675
<211> 933
<212> DNA
<213> Corynebacterium glutamicum
<220>
<221> CDS
<222> (101)..(910)
<223> RXN01168
<400> 675
ccgcacaagt tcgggttaag aaggtgcctg cgaaaaaggc agcaactaat cgtcgaaaag 60
taaaataaaa acgtcccgaa gggacgagga ggacaacacc atg agc agt gag gca 115
Met Ser Ser Glu Ala
1 5
gta gat gct acg acg ctg gtg att att cca acg tac aac gag ctg gaa 163
Val Asp Ala Thr Thr Leu Val Ile Ile Pro Thr Tyr Asn Glu Leu Glu
10 15 20
aac ctt cca ctc atc gtg gat cgc gtg cgc acc gca acc cct gac gtt 211
Asn Leu Pro Leu Ile Val Asp Arg Val Arg Thr Ala Thr Pro Asp Val
25 30 35
cac gta ctc atc gtg gac gac aac agc cca gac ggc acc ggc gag cgc 259
His Val Leu Ile Val Asp Asp Asn Ser Pro Asp Gly Thr Gly Glu Arg
40 45 50
gca gac aag ctt gct gct gac gac gac cac att ttt gtc ctc cac cgc 307
Ala Asp Lys Leu Ala Ala Asp Asp Asp His Ile Phe Val Leu His Arg
55 60 65
gaa ggc aaa ggc ggc ctg tgc gca gag tac atg gct ggc ttc cag tgg 355
Glu Gly Lys Gly Gly Leu Cys Ala Glu Tyr Met Ala Gly Phe Gln Trp
70 75 80 85
ggc ctg gag cgc gac tac cag gtc ctg tgc gaa atg gac gcc gac ggc 403
Gly Leu Glu Arg Asp Tyr Gln Val Leu Cys Glu Met Asp Ala Asp Gly
90 95 100
tcc cac gca cca gaa cag ctg cac ctg ctg ctc gct gag atc acc aat 451
Ser His Ala Pro Glu Gln Leu His Leu Leu Leu Ala Glu Ile Thr Asn
105 110 115
ggc gct gac ctg gtc atc ggc tcg cgc tac gtg cca ggc ggc cgc gta 499
Gly Ala Asp Leu Val Ile Gly Ser Arg Tyr Val Pro Gly Gly Arg Val
120 125 130
gtc aac tgg ccc aag aac cgt tgg ctc ttg tcc aag ggc ggc aac gtc 547
Val Asn Trp Pro Lys Asn Arg Trp Leu Leu Ser Lys Gly Gly Asn Val
135 140 145
tac atc agc gtc gcg ctc ggc gcc ggc ttg acc gat atg acc gca ggg 595
Tyr Ile Ser Val Ala Leu Gly Ala Gly Leu Thr Asp Met Thr Ala Gly
150 155 160 165
tac cgc gct ttt cga cgt gaa gtg cta gaa gca ctg ccg ctt gat gag 643
Tyr Arg Ala Phe Arg Arg Glu Val Leu Glu Ala Leu Pro Leu Asp Glu
170 175 180
ctc tcc aac gct ggg tac att ttc caa gtt gag att gcc tac cgt gca 691
Leu Ser Asn Ala Gly Tyr Ile Phe Gln Val Glu Ile Ala Tyr Arg Ala
185 190 195
gtt gaa gcc gga ttc gat gtt cgt gaa gtt ccc atc act ttc acc gag 739
Val Glu Ala Gly Phe Asp Val Arg Glu Val Pro Ile Thr Phe Thr Glu
200 205 210
cgt gag atc ggc gaa tcc aag ctg gac ggc agc ttt gtc aag gat tcc 787
Arg Glu Ile Gly Glu Ser Lys Leu Asp Gly Ser Phe Val Lys Asp Ser
215 220 225
ctg ctc gag gta acc aag tgg ggc ctc aag cac cgc ggt ggc cag gcc 835
Leu Leu Glu Val Thr Lys Trp Gly Leu Lys His Arg Gly Gly Gln Ala
230 235 240 245
aag gaa ctg tcc aag gaa atg gtc ggc ctg ctg aac tat gag tgg aag 883
Lys Glu Leu Ser Lys Glu Met Val Gly Leu Leu Asn Tyr Glu Trp Lys
250 255 260
cac ttc aaa aag cgc aac acc tgg ctc taaactgctt gccggttagt 930
His Phe Lys Lys Arg Asn Thr Trp Leu
265 270
gaa 933
<210> 676
<211> 270
<212> PRT
<213> Corynebacterium glutamicum
<400> 676
Met Ser Ser Glu Ala Val Asp Ala Thr Thr Leu Val Ile Ile Pro Thr
1 5 10 15
Tyr Asn Glu Leu Glu Asn Leu Pro Leu Ile Val Asp Arg Val Arg Thr
20 25 30
Ala Thr Pro Asp Val His Val Leu Ile Val Asp Asp Asn Ser Pro Asp
35 40 45
Gly Thr Gly Glu Arg Ala Asp Lys Leu Ala Ala Asp Asp Asp His Ile
50 55 60
Phe Val Leu His Arg Glu Gly Lys Gly Gly Leu Cys Ala Glu Tyr Met
65 70 75 80
Ala Gly Phe Gln Trp Gly Leu Glu Arg Asp Tyr Gln Val Leu Cys Glu
85 90 95
Met Asp Ala Asp Gly Ser His Ala Pro Glu Gln Leu His Leu Leu Leu
100 105 110
Ala Glu Ile Thr Asn Gly Ala Asp Leu Val Ile Gly Ser Arg Tyr Val
115 120 125
Pro Gly Gly Arg Val Val Asn Trp Pro Lys Asn Arg Trp Leu Leu Ser
130 135 140
Lys Gly Gly Asn Val Tyr Ile Ser Val Ala Leu Gly Ala Gly Leu Thr
145 150 155 160
Asp Met Thr Ala Gly Tyr Arg Ala Phe Arg Arg Glu Val Leu Glu Ala
165 170 175
Leu Pro Leu Asp Glu Leu Ser Asn Ala Gly Tyr Ile Phe Gln Val Glu
180 185 190
Ile Ala Tyr Arg Ala Val Glu Ala Gly Phe Asp Val Arg Glu Val Pro
195 200 205
Ile Thr Phe Thr Glu Arg Glu Ile Gly Glu Ser Lys Leu Asp Gly Ser
210 215 220
Phe Val Lys Asp Ser Leu Leu Glu Val Thr Lys Trp Gly Leu Lys His
225 230 235 240
Arg Gly Gly Gln Ala Lys Glu Leu Ser Lys Glu Met Val Gly Leu Leu
245 250 255
Asn Tyr Glu Trp Lys His Phe Lys Lys Arg Asn Thr Trp Leu
260 265 270
<210> 677
<211> 18
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: primer
<400> 677
ggaaacagta tgaccatg 18
<210> 678
<211> 17
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: primer
<400> 678
gtaaaacgac ggccagt 17
Claims (36)
- 표 1에 기재된 F-표시 유전자 중 어느 하나로 구성된 핵산 분자는 제외한, 서열 번호 1 내지 675에서 홀수 서열 번호로 구성된 군에서 선택된 뉴클레오티드 서열을 포함하는 단리된 핵산 분자 또는 그의 상보체.
- 표 1에 기재된 F-표시 유전자 중 어느 하나로 구성된 핵산 분자는 제외한, 서열 번호 2 내지 676에서 짝수 서열 번호로 구성된 군에서 선택된 아미노산 서열을 포함하는 폴리펩티드를 코딩하는 단리된 핵산 분자 또는 그의 상보체.
- 표 1에 기재된 F-표시 유전자 중 어느 하나로 구성된 핵산 분자는 제외한, 서열 번호 2 내지 676에서 짝수 서열 번호로 구성된 군에서 선택된 아미노산 서열을 포함하는 폴리펩티드의 자연발생 대립유전자 변이체를 코딩하는 단리된 핵산 분자 또는 그의 상보체.
- 표 1에 기재된 F-표시 유전자 중 어느 하나로 구성된 핵산 분자는 제외한, 서열 번호 1 내지 675에서 홀수 서열 번호 중 어느 하나의 전체 뉴클레오티드 서열과 50% 이상 동일한 뉴클레오티드 서열을 포함하는 단리된 핵산 분자 또는 그의 상보체.
- 표 1에 기재된 F-표시 유전자 중 어느 하나로 구성된 핵산 분자는 제외한, 서열 번호 1 내지 675에서 홀수 서열 번호 중 어느 하나의 뉴클레오티드 서열의 15개 이상의 인접 뉴클레오티드 단편을 포함하는 단리된 핵산 분자 또는 그의 상보체.
- 표 1에 기재된 F-표시 유전자 중 어느 하나로 구성된 핵산 분자는 제외한, 서열 번호 2 내지 676에서 짝수 서열 번호로 구성된 군에서 선택된 전체 아미노산 서열과 50% 이상 동일한 아미노산 서열을 포함하는 폴리펩티드를 코딩하는 단리된 핵산 분자 또는 그의 상보체.
- 표 1에 기재된 F-표시 유전자 중 어느 하나로 구성된 핵산 분자는 제외한, 65℃, 6배 염화나트륨/구연산나트륨(SSC)에서 서열 번호 1 내지 675에서 홀수 서열 번호 중 어느 하나의 뉴클레오티드 서열의 상보체와 혼성화하는 단리된 핵산 분자 또는 그의 상보체.
- 제1항 내지 제7항 중 어느 한 항의 핵산 분자 및 이종 폴리펩티드를 코딩하는 뉴클레오티드 서열을 포함하는 단리된 핵산 분자.
- 제1항 내지 제8항 중 어느 한 항의 핵산 분자를 포함하는 벡터.
- 제9항에 있어서, 발현 벡터인 벡터.
- 제10항의 발현 벡터로 형질감염된 숙주 세포.
- 제11항에 있어서, 상기 세포가 미생물인 숙주 세포.
- 제12항에 있어서, 상기 세포가 코리네박테리움 속 또는 브레비박테리움 (Brevibacterium) 속에 포함되는 것인 숙주 세포.
- 제11항에 있어서, 상기 핵산 분자의 발현으로 인해 상기 세포로부터의 정밀 화학물질의 생산이 조절되는 숙주 세포.
- 제14항에 있어서, 상기 정밀 화학물질이 유기산, 단백질생성 및 비-단백질생성 아미노산, 퓨린 및 피리미딘 염기, 뉴클레오시드, 뉴클레오티드, 지질, 포화 및 불포화 지방산, 디올, 탄수화물, 방향족 화합물, 비타민, 보조인자, 폴리케티드 및 효소로 구성된 군에서 선택된 것인 숙주 세포.
- 적절한 배양 배지에서 제11항의 숙주 세포를 배양함으로써 폴리펩티드를 생산하는 것을 포함하는 폴리펩티드의 생산 방법.
- 표 1에 기재된 F-표시 유전자 중 어느 하나로 코딩된 아미노산 서열은 제외한, 서열 번호 2 내지 676에서 짝수 서열 번호로 구성된 군에서 선택된 아미노산 서열을 포함하는 단리된 폴리펩티드.
- 표 1에 기재된 F-표시 유전자 중 어느 하나로 코딩된 아미노산 서열은 제외한, 서열 번호 2 내지 676에서 짝수 서열 번호로 구성된 군에서 선택된 아미노산 서열을 포함하는 폴리펩티드의 자연발생 대립유전자 변이체를 포함하는 단리된 폴리펩티드.
- 표 1에 기재된 F-표시 핵산 분자 중 어느 하나로 구성된 핵산 분자는 제외한, 서열 번호 1 내지 675에서 홀수 서열 번호 중 어느 하나의 전체 핵산 서열과 50% 이상 동일한 뉴클레오티드 서열을 포함하는 핵산 분자로 코딩된 단리된 폴리펩티드.
- 표 1에 기재된 F-표시 유전자 중 어느 하나로 코딩된 아미노산 서열은 제외한, 서열 번호 2 내지 676에서 짝수 서열 번호 중 어느 하나의 전체 아미노산 서열과 50% 이상 동일한 아미노산 서열을 포함하는 단리된 폴리펩티드.
- 표 1에 기재된 F-표시 유전자 중 어느 하나로 코딩된 아미노산 서열은 제외한, 서열 번호 2 내지 676 짝수 서열 번호 중 어느 하나의 아미노산 서열을 포함하 는 폴리펩티드의 생물학적 활성을 유지하는 상기 아미노산 서열의 단편을 포함하는 단리된 폴리펩티드.
- 표 1에 기재된 F-표시 핵산 분자 중 어느 하나로 구성된 핵산 분자는 제외한, 서열 번호 1 내지 675에서 홀수 서열 번호 중 어느 하나로 구성된 군에서 선택된 뉴클레오티드 서열로 코딩된 아미노산 서열을 포함하는 단리된 폴리펩티드.
- 제17항 내지 제22항 중 어느 한 항에 있어서, 이종 아미노산 서열을 추가로 포함하는 단리된 폴리펩티드.
- 정밀 화학물질을 생산하도록 제11항의 세포를 배양하는 것을 포함하는 정밀 화학물질의 생산 방법.
- 제24항에 있어서, 상기 배양물로부터 정밀 화학물질을 회수하는 단계를 추가로 포함하는 것인 방법.
- 제24항에 있어서, 상기 세포가 코리네박테리움 속 또는 브레비박테리움 속에 포함되는 것인 방법.
- 제24항에 있어서, 상기 세포가 코리네박테리움 글루타미쿰, 코리네박테리움 헤르쿨리스 (Corynebacterium herculis), 코리네박테리움 릴리움 (Corynebacterium lilium), 코리네박테리움 아세토아시도필룸 (Corynebacterium acetoacidophilum), 코리네박테리움 아세토글루타미쿰 (Corynebacterium acetoglutamicum), 코리네박테리움 아세토필룸 (Corynebacterium acetophilum), 코리네박테리움 암모니아게네스 (Corynebacterium ammoniagenes), 코리네박테리움 후지오켄세 (Corynebacterium fujiokense), 코리네박테리움 니트릴로필루스 (Corynebacterium nitrilophilus), 브레비박테리움 암모니아게네스 (Brevibacterium ammoniagenes), 브레비박테리움 부타니쿰 (Brevibacterium butanicum), 브레비박테리움 디바리카툼 (Brevibacterium divaricatum), 브레비박테리움 플라붐 (Brevibacterium flavum), 브레비박테리움 헤알리이 (Brevibacterium healii), 브레비박테리움 케토글루타미쿰 (Brevibacterium ketoglutamicum), 브레비박테리움 케토소레덕툼 (Brevibacterium ketosoreductum), 브레비박테리움 락토페르멘툼 (Brevibacterium lactofermentum), 브레비박테리움 리넨스 (Brevibacterium linens), 브레비박테리움 파라피놀리티쿰 (Brevibacterium paraffinolyticum), 및 표 3에 기재된 균주들로 구성된 군에서 선택된 것인 방법.
- 제24항에 있어서, 상기 벡터로부터의 핵산 분자 발현으로 인해 상기 정밀 화학물질의 생산이 조절되는 방법.
- 제24항에 있어서, 상기 정밀 화학물질이 유기산, 단백질생성 및 비-단백질생 성 아미노산, 퓨린 및 피리미딘 염기, 뉴클레오시드, 뉴클레오티드, 지질, 포화 및 불포화 지방산, 디올, 탄수화물, 방향족 화합물, 비타민, 보조인자, 폴리케티드 및 효소로 구성된 군에서 선택된 것인 방법.
- 제24항에 있어서, 상기 정밀 화학물질이 아미노산인 방법.
- 제30항에 있어서, 상기 아미노산이 리신, 글루타메이트, 글루타민, 알라닌, 아스파르테이트, 글리신, 세린, 트레오닌, 메티오닌, 시스테인, 발린, 루이신, 이소루이신, 아르기닌, 프롤린, 히스티딘, 티로신, 페닐알라닌 및 트립토판으로 구성된 군에서 선택된 것인 방법.
- 세포의 게놈 DNA가 제1항 내지 제8항 중 어느 한 항의 핵산 분자를 포함하는 변경된 세포를 배양하는 것을 포함하는 정밀 화학물질의 생산 방법.
- 대상에서 제1항 내지 제7항 중 어느 한 항의 핵산 분자 또는 제17항 내지 제22항 중 어느 한 항의 폴리펩티드 분자 중 하나 이상의 존재를 검출하여 코리네박테리움 디프테리아(Corynebacterium diphtheriae)의 존재 여부 또는 활성을 진단하는 것을 포함하는, 대상에서 코리네박테리움 디프테리아의 존재 여부 또는 활성의 진단 방법.
- 서열 번호 1 내지 675에서 홀수 서열 번호로 구성된 군에서 선택된 핵산 분자를 포함하는 숙주 세포로서, 상기 핵산 분자가 파괴된 것인 숙주 세포.
- 서열 번호 1 내지 675에서 홀수 서열 번호 중 어느 하나에 기재된 서열과 비교하여 핵산 변형체 하나 이상을 포함하는, 서열 번호 1 내지 675에서 홀수 서열 번호로 구성된 군에서 선택된 핵산 분자를 포함하는 숙주 세포.
- 핵산 분자의 조절 영역이 분자의 야생형 조절 영역에 대해 변형된, 서열 번호 1 내지 675에서 홀수 서열 번호로 구성된 군에서 선택된 핵산 분자를 포함하는 숙주 세포.
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KR1020017016590A KR100834989B1 (ko) | 1999-06-25 | 2000-06-23 | 막 합성 및 막 운반 관련 단백질을 코딩하는코리네박테리움 글루타미쿰 유전자 |
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KR1020067022650A KR100878332B1 (ko) | 1999-06-25 | 2000-06-23 | 막 합성 및 막 운반 관련 단백질을 코딩하는코리네박테리움 글루타미쿰 유전자 |
KR1020017016590A KR100834989B1 (ko) | 1999-06-25 | 2000-06-23 | 막 합성 및 막 운반 관련 단백질을 코딩하는코리네박테리움 글루타미쿰 유전자 |
Country Status (10)
Country | Link |
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EP (1) | EP1255839A2 (ko) |
JP (2) | JP2004513603A (ko) |
KR (3) | KR20070087032A (ko) |
CA (1) | CA2380863A1 (ko) |
CZ (1) | CZ20014660A3 (ko) |
ES (1) | ES2177476T1 (ko) |
MX (1) | MXPA01012845A (ko) |
SK (1) | SK18912001A3 (ko) |
TR (4) | TR200607441T2 (ko) |
WO (1) | WO2001000805A2 (ko) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60027161D1 (de) | 1999-07-02 | 2006-05-18 | Ajinomoto Kk | Für das saccharose-pts-enzym ii kodierende dna |
DE19941478A1 (de) | 1999-09-01 | 2001-03-08 | Degussa | Neue für das thrE-Gen codierende Nukleotidsequenzen und Verfahren zur fermentativen Herstellung von L-Threonin mit coryneformen Bakterien |
US6562607B2 (en) | 2000-05-04 | 2003-05-13 | Degussa-Huls Aktiengesellschaft | Nucleotide sequences coding for the cls gene |
DE10021831A1 (de) * | 2000-05-04 | 2001-11-08 | Degussa | Neue für das fadD15-Gen kodierende Nukleotidsequenzen |
DE10021829A1 (de) * | 2000-05-04 | 2001-11-08 | Degussa | Neue für das pgsA2-Gen kodierende Nukleotidsequenzen |
DE10021828A1 (de) * | 2000-05-04 | 2001-11-08 | Degussa | Neue für das cdsA-Gen kodierende Nukleotidsequenzen |
DE10021832A1 (de) * | 2000-05-04 | 2001-11-08 | Degussa | Neue für das cma-Gen kodierende Nukleotidsequenzen |
DE10021826A1 (de) * | 2000-05-04 | 2001-11-08 | Degussa | Neue für das cls-Gen kodierende Nukleotidsequenzen |
DE10023400A1 (de) | 2000-05-12 | 2001-11-15 | Degussa | Neue für das acp-Gen kodierende Nukleotidsequenzen |
US20020081673A1 (en) * | 2000-06-02 | 2002-06-27 | Bettina Mockel | Novel nucleotide sequences coding for the glbO gene |
DE10032173A1 (de) * | 2000-07-01 | 2002-01-17 | Degussa | Neue für das plsC-Gen kodierende Nukleotidsequenzen |
DE10045579A1 (de) * | 2000-09-15 | 2002-04-11 | Degussa | Neue für das atr61-Gen kodierende Nukleotidsequenzen |
AU2001293731A1 (en) * | 2000-09-19 | 2002-04-02 | Degussa A.G. | Nucleotide sequences coding for the dcta gene |
DE10057801A1 (de) * | 2000-11-22 | 2002-05-23 | Degussa | Neue für das cysQ-Gen kodierende Nukleotidsequenzen |
DE10154179A1 (de) * | 2001-11-05 | 2003-05-08 | Basf Ag | Gene die für membeansynthese-und Membrantransport-Proteine codieren |
DE10154270A1 (de) | 2001-11-05 | 2003-05-15 | Basf Ag | Gene die für Kohlenstoffmetabolismus- und Energieproduktion-Proteine codieren |
DE10163167A1 (de) * | 2001-12-21 | 2003-07-03 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren und Verwendung coryneformer Bakterien |
US7202067B2 (en) * | 2002-05-14 | 2007-04-10 | Martek Biosciences Corporation | Carotene synthase gene and uses therefor |
US7468262B2 (en) | 2003-05-16 | 2008-12-23 | Ajinomoto Co., Inc. | Polynucleotides encoding useful polypeptides in corynebacterium glutamicum ssp. lactofermentum |
DE102004009454A1 (de) * | 2004-02-27 | 2005-09-15 | Degussa Ag | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von rekombinanten Mikroorganismen |
WO2008126896A1 (ja) * | 2007-04-10 | 2008-10-23 | Ajinomoto Co., Inc. | 有機酸の製造方法 |
KR101694850B1 (ko) * | 2014-10-08 | 2017-01-10 | 씨제이제일제당 주식회사 | L-글루타민을 생산하는 미생물 및 이를 이용한 l-글루타민 생산방법 |
WO2018187324A1 (en) * | 2017-04-04 | 2018-10-11 | NNB Nutrition USA, LLC | Preparation of (r)-3-hydroxybutyric acid or its salts by one-step fermentation |
KR101968317B1 (ko) | 2018-02-23 | 2019-04-11 | 씨제이제일제당 주식회사 | 신규 l-트립토판 배출 단백질 및 이를 이용한 l-트립토판을 생산하는 방법 |
WO2019228937A1 (en) * | 2018-05-28 | 2019-12-05 | Universitaet Des Saarlandes | Means and methods for the production of glutarate |
EP3670525A1 (en) | 2018-12-18 | 2020-06-24 | Evonik Operations GmbH | Method for the fermentative production of l-lysine using c. glutamicum strains with a mutated kup transporter |
CN112143676B (zh) * | 2020-09-21 | 2022-03-18 | 山西大学 | 一株产碱性蛋白酶耐盐芽孢杆菌及其产碱性蛋白酶的方法与应用 |
KR102261851B1 (ko) * | 2021-01-15 | 2021-06-04 | 씨제이제일제당 (주) | 신규한 abc 트랜스포터 atp-결합 단백질 변이체 및 이를 이용한 l-라이신 생산 방법 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1196453B (it) * | 1986-07-04 | 1988-11-16 | Sclavo Spa | Elemento di dna di corynebacterium diphtheriae con proprieta' tipiche di un elemento di inserzione is |
US6649379B1 (en) * | 1987-06-12 | 2003-11-18 | Massachusetts Institute Of Technology | Method and deregulated enzyme for threonine production |
JP2967996B2 (ja) * | 1989-06-06 | 1999-10-25 | 協和醗酵工業株式会社 | L―トリプトファンの製造法 |
MY113040A (en) * | 1994-02-24 | 2001-11-30 | Ajinomoto Kk | Novel gene derived from coryneform bacteria and use thereof |
US6737248B2 (en) * | 1996-01-05 | 2004-05-18 | Human Genome Sciences, Inc. | Staphylococcus aureus polynucleotides and sequences |
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2000
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- 2000-06-23 TR TR2006/07442T patent/TR200607442T2/xx unknown
- 2000-06-23 ES ES00939001T patent/ES2177476T1/es active Pending
- 2000-06-23 WO PCT/IB2000/000926 patent/WO2001000805A2/en active Application Filing
- 2000-06-23 TR TR2001/03708T patent/TR200103708T2/xx unknown
- 2000-06-23 KR KR1020077015871A patent/KR20070087032A/ko not_active Application Discontinuation
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- 2000-06-23 CZ CZ20014660A patent/CZ20014660A3/cs unknown
- 2000-06-23 KR KR1020067022650A patent/KR100878332B1/ko active IP Right Grant
- 2000-06-23 CA CA002380863A patent/CA2380863A1/en not_active Abandoned
- 2000-06-23 SK SK1891-2001A patent/SK18912001A3/sk not_active Application Discontinuation
- 2000-06-23 KR KR1020017016590A patent/KR100834989B1/ko not_active IP Right Cessation
- 2000-06-23 JP JP2001506799A patent/JP2004513603A/ja active Pending
- 2000-06-23 EP EP00939001A patent/EP1255839A2/en not_active Ceased
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Also Published As
Publication number | Publication date |
---|---|
EP1255839A2 (en) | 2002-11-13 |
JP2006271389A (ja) | 2006-10-12 |
TR200607442T2 (tr) | 2007-02-21 |
TR200607443T2 (tr) | 2007-10-22 |
KR100878332B1 (ko) | 2009-01-14 |
JP2004513603A (ja) | 2004-05-13 |
CA2380863A1 (en) | 2001-01-04 |
KR100834989B1 (ko) | 2008-06-03 |
CZ20014660A3 (cs) | 2002-09-11 |
TR200607443T1 (tr) | 2007-04-24 |
ES2177476T1 (es) | 2002-12-16 |
MXPA01012845A (es) | 2002-07-09 |
WO2001000805A3 (en) | 2001-10-25 |
TR200607441T2 (tr) | 2007-02-21 |
SK18912001A3 (sk) | 2002-10-08 |
WO2001000805A2 (en) | 2001-01-04 |
KR20030002295A (ko) | 2003-01-08 |
TR200103708T2 (tr) | 2002-08-21 |
KR20060118626A (ko) | 2006-11-23 |
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