KR20070047319A - 호흡기 질환 치료용 비페닐옥시아세트산 유도체 - Google Patents
호흡기 질환 치료용 비페닐옥시아세트산 유도체 Download PDFInfo
- Publication number
- KR20070047319A KR20070047319A KR1020077004365A KR20077004365A KR20070047319A KR 20070047319 A KR20070047319 A KR 20070047319A KR 1020077004365 A KR1020077004365 A KR 1020077004365A KR 20077004365 A KR20077004365 A KR 20077004365A KR 20070047319 A KR20070047319 A KR 20070047319A
- Authority
- KR
- South Korea
- Prior art keywords
- biphenyl
- oxy
- chloro
- fluoro
- propanoic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *c(cc1)cc(B(O*)O*)c1O* Chemical compound *c(cc1)cc(B(O*)O*)c1O* 0.000 description 4
- FPEFOTGZWPJNGN-UHFFFAOYSA-N CC(C(O)=O)Oc(c(-c(cc1)cc(F)c1C(NC1=CC1)=O)c1)ccc1Cl Chemical compound CC(C(O)=O)Oc(c(-c(cc1)cc(F)c1C(NC1=CC1)=O)c1)ccc1Cl FPEFOTGZWPJNGN-UHFFFAOYSA-N 0.000 description 1
- SEMABQFCWXUGNS-UHFFFAOYSA-N CC(C(O)=O)Oc(c(-c(cc1)cc(F)c1C(NC1CCCC1)=O)c1)ccc1Cl Chemical compound CC(C(O)=O)Oc(c(-c(cc1)cc(F)c1C(NC1CCCC1)=O)c1)ccc1Cl SEMABQFCWXUGNS-UHFFFAOYSA-N 0.000 description 1
- AFIBARHNKQFRTR-LBPRGKRZSA-N CC(C)N(C)C(c(ccc(-c1cc(Cl)ccc1O[C@@H](C)C(O)=O)c1)c1F)=O Chemical compound CC(C)N(C)C(c(ccc(-c1cc(Cl)ccc1O[C@@H](C)C(O)=O)c1)c1F)=O AFIBARHNKQFRTR-LBPRGKRZSA-N 0.000 description 1
- IPWKHHSGDUIRAH-UHFFFAOYSA-N CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C Chemical compound CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C IPWKHHSGDUIRAH-UHFFFAOYSA-N 0.000 description 1
- VZBLMOJEAFVHIR-UHFFFAOYSA-N CS(c(cc1)c(C(F)(F)F)cc1-c(cc(cc1)F)c1OCC(O)=O)(=O)=O Chemical compound CS(c(cc1)c(C(F)(F)F)cc1-c(cc(cc1)F)c1OCC(O)=O)(=O)=O VZBLMOJEAFVHIR-UHFFFAOYSA-N 0.000 description 1
- NPNRUFDDBTZCQB-UHFFFAOYSA-N OC(COc(cc1)c(C(C2)C=CC(C(N3CCCC3)=O)=C2F)cc1F)=O Chemical compound OC(COc(cc1)c(C(C2)C=CC(C(N3CCCC3)=O)=C2F)cc1F)=O NPNRUFDDBTZCQB-UHFFFAOYSA-N 0.000 description 1
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
- C07C59/13—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
- C07C59/135—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups containing halogen
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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Applications Claiming Priority (2)
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|---|---|---|---|
| GBGB0418830.6A GB0418830D0 (en) | 2004-08-24 | 2004-08-24 | Novel compounds |
| GB0418830.6 | 2004-08-24 |
Publications (1)
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|---|---|
| KR20070047319A true KR20070047319A (ko) | 2007-05-04 |
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| NO (1) | NO20071577L (enExample) |
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| UY (1) | UY29079A1 (enExample) |
| WO (1) | WO2006021759A1 (enExample) |
| ZA (1) | ZA200701584B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
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| SE0301010D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301009D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
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| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| ATE517085T1 (de) | 2004-11-23 | 2011-08-15 | Astrazeneca Ab | Zur behandlung von atemwegserkrankungen geeignete phenoxyessigsäurederivate |
| WO2007010350A1 (en) * | 2005-07-19 | 2007-01-25 | Pfizer Products Inc. | Synthesis of therapeutic diphenyl ethers |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| JP5155171B2 (ja) | 2005-10-06 | 2013-02-27 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
| EP1948630A2 (en) * | 2005-11-05 | 2008-07-30 | AstraZeneca AB | Novel compounds |
| EP1963259B1 (en) * | 2005-12-15 | 2012-02-15 | AstraZeneca AB | Substituted diphenylethers, -amines, -sulfides and -methanes for the treatment of respiratory disease |
| UA100983C2 (ru) * | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
| MX2010003621A (es) * | 2007-10-01 | 2010-04-14 | Hoffmann La Roche | N-heterociclil biaril carboxamidas como antagonistas del receptor ccr. |
| GB0720389D0 (en) | 2007-10-18 | 2008-11-12 | Prosidion Ltd | G-Protein Coupled Receptor Agonists |
| US8575158B2 (en) | 2010-07-05 | 2013-11-05 | Actelion Pharmaceuticals Ltd. | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| SG11201402796SA (en) | 2011-12-16 | 2014-06-27 | Atopix Therapeutics Ltd | Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis |
| BR112014015081A8 (pt) | 2011-12-21 | 2017-06-13 | Actelion Pharmaceuticals Ltd | derivados heterocíclicos e seu uso como moduladores do receptor d2 de prostaglandina |
| JP6127135B2 (ja) | 2012-07-05 | 2017-05-10 | アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd | 1−フェニル置換ヘテロシクリル誘導体及びプロスタグランジンd2受容体調節剤としてのそれらの使用 |
| US12440477B2 (en) | 2017-12-14 | 2025-10-14 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| US10513504B2 (en) | 2018-03-08 | 2019-12-24 | Apotex Inc. | Processes for the preparation of apalutamide and intermediates thereof |
| WO2021220137A2 (en) * | 2020-04-27 | 2021-11-04 | Sapir Pharmaceuticals Inc. | Pannexin-1 inhibitors for the treatment of sars-cov-2 infected covid-19 patients with or without an associated acute respiratory syndrome |
| CN115197084A (zh) * | 2022-07-11 | 2022-10-18 | 中国船舶重工集团公司第七一八研究所 | 一种恩杂鲁胺关键中间体的制备方法 |
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| BE790679A (fr) | 1971-11-03 | 1973-04-27 | Ici Ltd | Derives de l'indole |
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| GB1585963A (en) | 1976-10-14 | 1981-03-11 | Lilly Industries Ltd | Aryl sulphur compounds |
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| FR2428629A1 (fr) | 1978-06-14 | 1980-01-11 | Hexachimie | Nouveaux composes bis(aryloxycarboxyliques), leur preparation et leur utilisation en therapeutique |
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| US20040097555A1 (en) * | 2000-12-26 | 2004-05-20 | Shinegori Ohkawa | Concomitant drugs |
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| JP2005520858A (ja) | 2002-03-20 | 2005-07-14 | メタボレックス, インコーポレイテッド | 置換フェニル酢酸 |
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| SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
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| SE0301010D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301009D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
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| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
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| KR20070045153A (ko) | 2004-05-29 | 2007-05-02 | 7티엠 파마 에이/에스 | 의약용 씨알티에이치2 수용체 리간드 |
| GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| GB0422057D0 (en) | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| ATE517085T1 (de) | 2004-11-23 | 2011-08-15 | Astrazeneca Ab | Zur behandlung von atemwegserkrankungen geeignete phenoxyessigsäurederivate |
| GB0510584D0 (en) | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| JP5155171B2 (ja) | 2005-10-06 | 2013-02-27 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
| EP1948630A2 (en) | 2005-11-05 | 2008-07-30 | AstraZeneca AB | Novel compounds |
| EP1963259B1 (en) | 2005-12-15 | 2012-02-15 | AstraZeneca AB | Substituted diphenylethers, -amines, -sulfides and -methanes for the treatment of respiratory disease |
| UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
-
2004
- 2004-08-24 GB GBGB0418830.6A patent/GB0418830D0/en not_active Ceased
-
2005
- 2005-08-19 AR ARP050103487A patent/AR053092A1/es unknown
- 2005-08-22 US US11/574,076 patent/US7737135B2/en not_active Expired - Fee Related
- 2005-08-22 AT AT05773308T patent/ATE447551T1/de not_active IP Right Cessation
- 2005-08-22 EP EP05773308A patent/EP1784388B3/en not_active Expired - Lifetime
- 2005-08-22 AU AU2005276281A patent/AU2005276281A1/en not_active Abandoned
- 2005-08-22 CN CN2005800364721A patent/CN101048369B/zh not_active Expired - Fee Related
- 2005-08-22 BR BRPI0514448-5A patent/BRPI0514448A/pt not_active Application Discontinuation
- 2005-08-22 MX MX2007002095A patent/MX2007002095A/es not_active Application Discontinuation
- 2005-08-22 WO PCT/GB2005/003255 patent/WO2006021759A1/en not_active Ceased
- 2005-08-22 JP JP2007528960A patent/JP4990773B2/ja not_active Expired - Fee Related
- 2005-08-22 DE DE602005017503T patent/DE602005017503D1/de not_active Expired - Lifetime
- 2005-08-22 RU RU2007106039/04A patent/RU2007106039A/ru unknown
- 2005-08-22 KR KR1020077004365A patent/KR20070047319A/ko not_active Withdrawn
- 2005-08-22 ES ES05773308T patent/ES2335425T7/es active Active
- 2005-08-22 CA CA002575200A patent/CA2575200A1/en not_active Abandoned
- 2005-08-23 UY UY29079A patent/UY29079A1/es not_active Application Discontinuation
- 2005-08-23 TW TW094128765A patent/TW200621690A/zh unknown
-
2007
- 2007-01-29 IL IL181049A patent/IL181049A0/en unknown
- 2007-02-22 ZA ZA200701584A patent/ZA200701584B/xx unknown
- 2007-03-26 NO NO20071577A patent/NO20071577L/no not_active Application Discontinuation
-
2009
- 2009-12-18 US US12/642,244 patent/US8163727B2/en not_active Expired - Fee Related
-
2011
- 2011-12-06 US US13/311,647 patent/US8722741B2/en not_active Expired - Fee Related
Also Published As
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| US20100160285A1 (en) | 2010-06-24 |
| IL181049A0 (en) | 2007-07-04 |
| BRPI0514448A (pt) | 2008-06-10 |
| GB0418830D0 (en) | 2004-09-22 |
| EP1784388B8 (en) | 2010-05-19 |
| US8163727B2 (en) | 2012-04-24 |
| US7737135B2 (en) | 2010-06-15 |
| ATE447551T1 (de) | 2009-11-15 |
| TW200621690A (en) | 2006-07-01 |
| AR053092A1 (es) | 2007-04-25 |
| CN101048369B (zh) | 2010-09-08 |
| UY29079A1 (es) | 2006-03-31 |
| WO2006021759A1 (en) | 2006-03-02 |
| JP2008510778A (ja) | 2008-04-10 |
| ZA200701584B (en) | 2008-09-25 |
| RU2007106039A (ru) | 2008-10-10 |
| ES2335425T3 (es) | 2010-03-26 |
| EP1784388B1 (en) | 2009-11-04 |
| US20120178732A1 (en) | 2012-07-12 |
| ES2335425T7 (es) | 2013-02-14 |
| CN101048369A (zh) | 2007-10-03 |
| EP1784388B3 (en) | 2012-09-05 |
| EP1784388A1 (en) | 2007-05-16 |
| CA2575200A1 (en) | 2006-03-02 |
| JP4990773B2 (ja) | 2012-08-01 |
| US8722741B2 (en) | 2014-05-13 |
| AU2005276281A1 (en) | 2006-03-02 |
| MX2007002095A (es) | 2007-03-29 |
| NO20071577L (no) | 2007-05-02 |
| US20080132480A1 (en) | 2008-06-05 |
| DE602005017503D1 (de) | 2009-12-17 |
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